Compounds > piperazine
Page last updated: 2024-08-16

piperazine and pyrimidine

piperazine has been researched along with pyrimidine in 7 studies

Research

Studies (7)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's6 (85.71)24.3611
2020's1 (14.29)2.80

Authors

AuthorsStudies
Fotsch, C; St Jean, DJ1
Hao, M; Li, G; Li, Y; Wang, Y; Yan, Y; Yang, L; Zhang, S1
Dai, H; Doran, SD; Piotrowski, DW; Prakash, C; Ryder, TF; Sharma, R; Sun, H1
Baranowski, TC; Barnes, S; Blake, AL; Bojarski, AJ; Ehalt, AJ; Fernando, NT; Klenc, J; Paranjpe, S; Raszkiewicz, A; Raux, EA; Sączewski, J; Satała, G; Strekowski, L; Sullivan, SM1
Ahmed, N; Hassan, MI; Idrees, D; Khan, P; Parveen, I1
Bajda, M; Bednarski, M; Bucki, A; Czopek, A; Głuch-Lutwin, M; Jastrzębska-Więsek, M; Jończyk, J; Koczurkiewicz, P; Kołaczkowski, M; Partyka, A; Pawłowski, M; Piska, K; Siwek, A; Wesołowska, A; Zagórska, A1
Chalapathi, PV; Nagalakshmamma, V; Nagaraju, C; Pasala, C; Thyagaraju, K; Umamaheswari, A; Venkataswamy, M1

Reviews

1 review(s) available for piperazine and pyrimidine

ArticleYear
Mitigating heterocycle metabolism in drug discovery.
    Journal of medicinal chemistry, 2012, Jul-12, Volume: 55, Issue:13

    Topics: Animals; Biotransformation; Databases, Factual; Drug Discovery; Drug Interactions; Heterocyclic Compounds, 1-Ring; Heterocyclic Compounds, 4 or More Rings; Humans; Mice; Pharmaceutical Preparations; Rats

2012

Other Studies

6 other study(ies) available for piperazine and pyrimidine

ArticleYear
Combined 3D-QSAR, molecular docking, and molecular dynamics study on piperazinyl-glutamate-pyridines/pyrimidines as potent P2Y12 antagonists for inhibition of platelet aggregation.
    Journal of chemical information and modeling, 2011, Oct-24, Volume: 51, Issue:10

    Topics: Biological Availability; Glutamic Acid; Heterocyclic Compounds, 1-Ring; Humans; Molecular Dynamics Simulation; Piperazine; Piperazines; Platelet Aggregation; Protein Conformation; Purinergic P2Y Receptor Antagonists; Pyridines; Pyrimidines; Quantitative Structure-Activity Relationship; Receptors, Purinergic P2Y12; Reproducibility of Results

2011
Metabolism, excretion, and pharmacokinetics of ((3,3-difluoropyrrolidin-1-yl)((2S,4S)-4-(4-(pyrimidin-2-yl)piperazin-1-yl)pyrrolidin-2-yl)methanone, a dipeptidyl peptidase inhibitor, in rat, dog and human.
    Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:11

    Topics: Amides; Animals; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Diabetes Mellitus, Type 2; Dipeptidyl-Peptidase IV Inhibitors; Dipeptidyl-Peptidases and Tripeptidyl-Peptidases; Dogs; Feces; Female; Humans; Hydrolysis; Hydroxylation; Male; Metabolic Detoxication, Phase II; Microsomes, Liver; Molecular Docking Simulation; Piperazine; Piperazines; Pyrimidines; Pyrrolidines; Rats; Rats, Sprague-Dawley

2012
Synthesis and Structure-Activity Relationship Analysis of 5-HT₇ Receptor Antagonists: Piperazin-1-yl Substituted Unfused Heterobiaryls.
    Molecules (Basel, Switzerland), 2016, Mar-31, Volume: 21, Issue:4

    Topics: Humans; Ligands; Piperazine; Piperazines; Pyrimidines; Receptors, Serotonin; Serotonin Antagonists; Structure-Activity Relationship

2016
Synthesis, estrogen receptor binding affinity and molecular docking of pyrimidine-piperazine-chromene and -quinoline conjugates.
    Bioorganic & medicinal chemistry letters, 2017, 09-15, Volume: 27, Issue:18

    Topics: Antineoplastic Agents; Benzopyrans; Binding Sites; Cell Proliferation; Cell Survival; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; HEK293 Cells; Humans; MCF-7 Cells; Molecular Docking Simulation; Molecular Structure; Piperazine; Piperazines; Proto-Oncogene Proteins c-bcl-2; Pyrimidines; Quinolines; Structure-Activity Relationship

2017
Characteristics of metabolic stability and the cell permeability of 2-pyrimidinyl-piperazinyl-alkyl derivatives of 1H-imidazo[2,1-f]purine-2,4(3H,8H)-dione with antidepressant- and anxiolytic-like activities.
    Chemical biology & drug design, 2019, Volume: 93, Issue:4

    Topics: Animals; Anti-Anxiety Agents; Antidepressive Agents; Binding Sites; Imidazoles; Maze Learning; Mice; Microsomes, Liver; Molecular Dynamics Simulation; Permeability; Phosphoric Diester Hydrolases; Piperazine; Protein Binding; Protein Structure, Tertiary; Purines; Pyrimidines; Receptor, Serotonin, 5-HT1A; Structure-Activity Relationship

2019
Design, synthesis, anti-tobacco mosaic viral and molecule docking simulations of urea/thiourea derivatives of 2-(piperazine-1-yl)-pyrimidine and 1-(4-Fluoro/4-Chloro phenyl)-piperazine and 1-(4-Chloro phenyl)-piperazine - A study.
    Bioorganic chemistry, 2020, Volume: 102

    Topics: Antiviral Agents; Dose-Response Relationship, Drug; Drug Design; Microbial Sensitivity Tests; Molecular Docking Simulation; Molecular Structure; Piperazine; Pyrimidines; Structure-Activity Relationship; Tobacco Mosaic Virus; Urea

2020