piperaquine has been researched along with trimethoprim in 6 studies
| Studies (piperaquine) | Trials (piperaquine) | Recent Studies (post-2010) (piperaquine) | Studies (trimethoprim) | Trials (trimethoprim) | Recent Studies (post-2010) (trimethoprim) |
|---|---|---|---|---|---|
| 638 | 227 | 497 | 6,989 | 845 | 894 |
| Protein | Taxonomy | piperaquine (IC50) | trimethoprim (IC50) |
|---|---|---|---|
| Chain A, Dihydrofolate reductase | Bacillus anthracis | 77200 | |
| Chain A, dihydrofolate reductase (DHFR) | Bacillus anthracis | 77200 | |
| Dihydrofolate reductase | Mycobacterium avium | 0.2588 | |
| Dihydrofolate reductase | Homo sapiens (human) | 1.8206 | |
| Dihydrofolate reductase | Lacticaseibacillus casei | 0.3493 | |
| Dihydrofolate reductase type 1 | Escherichia coli | 0.25 | |
| Dihydrofolate reductase | Neisseria gonorrhoeae | 0.45 | |
| Thymidylate synthase | Homo sapiens (human) | 3.405 | |
| Dihydrofolate reductase | Staphylococcus aureus | 0.0875 | |
| Thymidylate synthase | Escherichia coli K-12 | 3.405 | |
| Dihydrofolate reductase | Escherichia coli K-12 | 0.6064 | |
| Bifunctional dihydrofolate reductase-thymidylate synthase | Plasmodium falciparum K1 | 0.01 | |
| Dihydrofolate reductase type 1 from Tn4003 | Staphylococcus aureus | 0.023 | |
| Dipeptidyl peptidase 4 | Rattus norvegicus (Norway rat) | 2.7 | |
| Dihydrofolate reductase | Pneumocystis carinii | 0.7061 | |
| Dihydrofolate reductase | Candida albicans | 0.1361 | |
| Dipeptidyl peptidase 4 | Homo sapiens (human) | 2.7 | |
| 5-hydroxytryptamine receptor 2B | Rattus norvegicus (Norway rat) | 0.45 | |
| Metabotropic glutamate receptor 5 | Rattus norvegicus (Norway rat) | 2.73 | |
| Mu-type opioid receptor | Cavia porcellus (domestic guinea pig) | 2.8 | |
| Bifunctional dihydrofolate reductase-thymidylate synthase | Toxoplasma gondii | 3.2206 | |
| Bifunctional dihydrofolate reductase-thymidylate synthase | Plasmodium berghei ANKA | 0.12 | |
| Dihydrofolate reductase | Streptococcus pneumoniae TIGR4 | 0.0297 | |
| Dihydrofolate reductase | Lactococcus lactis subsp. lactis Il1403 | 0.45 | |
| Dihydrofolate reductase | Bacillus anthracis | 4.77 | |
| Dihydrofolate reductase | Rattus norvegicus (Norway rat) | 1.244 | |
| Dihydrofolate reductase | Pneumocystis jirovecii | 0.092 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 5 (83.33) | 29.6817 |
| 2010's | 1 (16.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Chalermrut, K; Krudsood, S; Looareesuwan, S; Pengruksa, C; Silachamroon, U; Srivilairit, S; Treeprasertsuk, S; Wilairatana, P | 1 |
| Dolecek, C; Dong, TH; Farrar, J; Le, HT; Nguyen, TD; Nguyen, TT; Pham, PM; Stepniewska, K; Tran, TH; Tran, TT; White, NJ | 1 |
| Binh, TQ; de Vries, PJ; Giao, PT; Hung, le Q; Kager, PA; Nam, NV | 1 |
| Diallo, TO; Doui-Doumgba, K; Flori, P; Garraud, O; Gbagba, FE; Nambei, WS; Ndadjimbaye, V; Ndémanga, J; Perraut, R | 1 |
| Ashton, M; Friberg Hietala, S; Hai, TN; Röshammar, D; Van Huong, N | 1 |
| Faye, B; Faye, O; Kane, D; Kassi, KF; Kiki Barro, CP; Kone, M; Kuete, T; Menan, H; N'diaye, JL; Oga, AS; Same-Ekobo, A; Tine, R; Vicky, AM; Yavo, W | 1 |
6 trial(s) available for piperaquine and trimethoprim
| Article | Year |
|---|---|
An open randomized clinical trial of Artecom vs artesunate-mefloquine in the treatment of acute uncomplicated falciparum malaria in Thailand.
Topics: Adolescent; Adult; Aged; Antimalarials; Artemisinins; Artesunate; Child; Drug Combinations; Drug Resistance, Multiple; Female; Humans; Malaria, Falciparum; Male; Mefloquine; Middle Aged; Quinolines; Sesquiterpenes; Thailand; Trimethoprim | 2002 |
Dihydroartemisinin-piperaquine against multidrug-resistant Plasmodium falciparum malaria in Vietnam: randomised clinical trial.
Topics: Adolescent; Adult; Animals; Antimalarials; Artemisinins; Child; Child, Preschool; Drug Combinations; Drug Resistance, Multiple; Female; Follow-Up Studies; Humans; Malaria, Falciparum; Male; Pilot Projects; Plasmodium falciparum; Quinolines; Sesquiterpenes; Treatment Outcome; Trimethoprim; Vietnam | 2004 |
CV8, a new combination of dihydroartemisinin, piperaquine, trimethoprim and primaquine, compared with atovaquone-proguanil against falciparum malaria in Vietnam.
Topics: Adolescent; Adult; Aged; Animals; Antimalarials; Artemisinins; Atovaquone; Drug Combinations; Drug Therapy, Combination; Female; Humans; Malaria, Falciparum; Male; Middle Aged; Naphthoquinones; Parasitemia; Plasmodium falciparum; Primaquine; Proguanil; Quinolines; Sesquiterpenes; Treatment Outcome; Trimethoprim; Vietnam | 2004 |
Efficacy comparison between anti-malarial drugs in Africans presenting with mild malaria in the Central Republic of Africa: a preliminary study.
Topics: Adolescent; Adult; Animals; Antimalarials; Artemisinins; Central African Republic; Drug Combinations; Drug Resistance; Drug Therapy, Combination; Female; Humans; Malaria, Falciparum; Male; Parasitemia; Parasitic Sensitivity Tests; Patient Compliance; Plasmodium falciparum; Pyrimethamine; Quinine; Quinolines; Sesquiterpenes; Sulfadoxine; Treatment Outcome; Trimethoprim | 2005 |
Pharmacokinetics of piperaquine after repeated oral administration of the antimalarial combination CV8 in 12 healthy male subjects.
Topics: Administration, Oral; Adult; Antimalarials; Artemisinins; Chromatography, High Pressure Liquid; Drug Combinations; Fasting; Half-Life; Humans; Male; Middle Aged; Pilot Projects; Primaquine; Quinolines; Sesquiterpenes; Trimethoprim | 2006 |
Comparative study of the efficacy and tolerability of dihydroartemisinin-piperaquine-trimethoprim versus artemether-lumefantrine in the treatment of uncomplicated Plasmodium falciparum malaria in Cameroon, Ivory Coast and Senegal.
Topics: Adolescent; Adult; Animals; Antimalarials; Artemether; Artemisinins; Cameroon; Child; Child, Preschool; Cote d'Ivoire; Drug Therapy, Combination; Ethanolamines; Female; Fluorenes; Humans; Lumefantrine; Malaria, Falciparum; Male; Middle Aged; Quinolines; Senegal; Treatment Outcome; Trimethoprim; Young Adult | 2011 |