Page last updated: 2024-09-03

piperaquine and methylene blue

piperaquine has been researched along with methylene blue in 4 studies

Compound Research Comparison

Studies (piperaquine)	Trials (piperaquine)	Recent Studies (post-2010) (piperaquine)	Studies (methylene blue)	Trials (methylene blue)	Recent Studies (post-2010) (methylene blue)
638	227	497	11,067	394	4,258

Protein Interaction Comparison

Protein	Taxonomy	methylene blue (IC50)
Chain E, Fibrin beta chain	Homo sapiens (human)	9.253
integrase, partial	Human immunodeficiency virus 1	1.958
lens epithelium-derived growth factor p75	Homo sapiens (human)	1.958
Apoptotic peptidase activating factor 1	Homo sapiens (human)	15.5
neutrophil cytosol factor 1	Homo sapiens (human)	0.39
caspase-9 isoform alpha precursor	Homo sapiens (human)	17
caspase-3 isoform a preproprotein	Homo sapiens (human)	17
Glutathione reductase	Plasmodium falciparum 3D7	6.4
Amyloid-beta precursor protein	Homo sapiens (human)	0.5
Microtubule-associated protein tau	Homo sapiens (human)	2.2333
Alpha-1B adrenergic receptor	Rattus norvegicus (Norway rat)	0.5
Amine oxidase [flavin-containing] A	Homo sapiens (human)	0.07
Alpha-1D adrenergic receptor	Rattus norvegicus (Norway rat)	0.5
Alpha-1A adrenergic receptor	Rattus norvegicus (Norway rat)	0.5

Research

Studies (4)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	1 (25.00)	29.6817
2010's	3 (75.00)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Becker, K; Davioud-Charvet, E; Friebolin, W; Furrer, J; Jannack, B; Lanzer, M; Oeser, T; Sanchez, CP; Wenzel, N; Yardley, V	1
Fidock, DA; Flannery, EL; Winzeler, EA	1
Adjalley, SH; Eappen, AG; Eastman, RT; Ekland, EH; Fidock, DA; Hoffman, SL; Johnston, GL; Lee, MC; Li, T; Richman, A; Sim, BK	1
Bousema, T; Bradley, J; Brown, JM; Chen, I; Diarra, K; Diawara, H; Dicko, A; Drakeley, C; Gosling, R; Hwang, J; Issiaka, D; Keita, S; Kone, DT; Lanke, K; Mahamar, A; McCulloch, C; Müller, O; Roh, ME; Sanogo, K; Soumare, HM; Srinivasan, V; Stone, WJR; Traore, SF	1

Reviews

1 review(s) available for piperaquine and methylene blue

Article	Year
Using genetic methods to define the targets of compounds with antimalarial activity. Journal of medicinal chemistry, 2013, Oct-24, Volume: 56, Issue:20 Topics: Animals; Anopheles; Antimalarials; Drug Resistance; Genetic Association Studies; Genome, Protozoan; Humans; Malaria, Falciparum; Molecular Targeted Therapy; Plasmodium falciparum	2013

Trials

1 trial(s) available for piperaquine and methylene blue

Article	Year
Efficacy and safety of primaquine and methylene blue for prevention of Plasmodium falciparum transmission in Mali: a phase 2, single-blind, randomised controlled trial. The Lancet. Infectious diseases, 2018, Volume: 18, Issue:6 Topics: Adolescent; Adult; Amodiaquine; Artemisinins; Child; Child, Preschool; Drug Combinations; Humans; Malaria, Falciparum; Mali; Methylene Blue; Middle Aged; Plasmodium falciparum; Primaquine; Pyrimethamine; Quinolines; Sulfadoxine; Young Adult	2018

Article

Year

Efficacy and safety of primaquine and methylene blue for prevention of Plasmodium falciparum transmission in Mali: a phase 2, single-blind, randomised controlled trial.

The Lancet. Infectious diseases, 2018, Volume: 18, Issue:6

Topics: Adolescent; Adult; Amodiaquine; Artemisinins; Child; Child, Preschool; Drug Combinations; Humans; Malaria, Falciparum; Mali; Methylene Blue; Middle Aged; Plasmodium falciparum; Primaquine; Pyrimethamine; Quinolines; Sulfadoxine; Young Adult

2018

Other Studies

2 other study(ies) available for piperaquine and methylene blue

Article	Year
Antimalarial dual drugs based on potent inhibitors of glutathione reductase from Plasmodium falciparum. Journal of medicinal chemistry, 2008, Mar-13, Volume: 51, Issue:5 Topics: Animals; Antimalarials; Biological Transport; Cell Line, Tumor; Chloroquine; Drug Resistance; Drug Therapy, Combination; Glutathione Reductase; Humans; In Vitro Techniques; Malaria; Mice; Mice, Inbred BALB C; Naphthalenes; Parasitic Sensitivity Tests; Plasmodium berghei; Plasmodium falciparum; Structure-Activity Relationship	2008
Quantitative assessment of Plasmodium falciparum sexual development reveals potent transmission-blocking activity by methylene blue. Proceedings of the National Academy of Sciences of the United States of America, 2011, Nov-22, Volume: 108, Issue:47 Topics: Amodiaquine; Animals; Anopheles; Antimalarials; Artemisinins; Blotting, Southern; Dose-Response Relationship, Drug; Ethanolamines; Fluorenes; Genetic Vectors; Germ Cells, Plant; Green Fluorescent Proteins; Luciferases; Lumefantrine; Malaria; Methylene Blue; Naphthyridines; Plasmodium falciparum; Quinolines; Sexual Development	2011

Article

Year

Antimalarial dual drugs based on potent inhibitors of glutathione reductase from Plasmodium falciparum.

Journal of medicinal chemistry, 2008, Mar-13, Volume: 51, Issue:5

Topics: Animals; Antimalarials; Biological Transport; Cell Line, Tumor; Chloroquine; Drug Resistance; Drug Therapy, Combination; Glutathione Reductase; Humans; In Vitro Techniques; Malaria; Mice; Mice, Inbred BALB C; Naphthalenes; Parasitic Sensitivity Tests; Plasmodium berghei; Plasmodium falciparum; Structure-Activity Relationship

2008

Quantitative assessment of Plasmodium falciparum sexual development reveals potent transmission-blocking activity by methylene blue.

Proceedings of the National Academy of Sciences of the United States of America, 2011, Nov-22, Volume: 108, Issue:47

Topics: Amodiaquine; Animals; Anopheles; Antimalarials; Artemisinins; Blotting, Southern; Dose-Response Relationship, Drug; Ethanolamines; Fluorenes; Genetic Vectors; Germ Cells, Plant; Green Fluorescent Proteins; Luciferases; Lumefantrine; Malaria; Methylene Blue; Naphthyridines; Plasmodium falciparum; Quinolines; Sexual Development

2011