piperaquine has been researched along with mefloquine in 65 studies
| Studies (piperaquine) | Trials (piperaquine) | Recent Studies (post-2010) (piperaquine) | Studies (mefloquine) | Trials (mefloquine) | Recent Studies (post-2010) (mefloquine) |
|---|---|---|---|---|---|
| 638 | 227 | 497 | 71 | 0 | 66 |
| 638 | 227 | 497 | 2,212 | 342 | 560 |
| Protein | Taxonomy | piperaquine (IC50) | mefloquine (IC50) |
|---|---|---|---|
| Potassium voltage-gated channel subfamily H member 2 | Homo sapiens (human) | 2.6 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (4.62) | 18.7374 |
| 1990's | 1 (1.54) | 18.2507 |
| 2000's | 11 (16.92) | 29.6817 |
| 2010's | 39 (60.00) | 24.3611 |
| 2020's | 11 (16.92) | 2.80 |
| Authors | Studies |
|---|---|
| Biamonte, MA; Le Roch, KG; Wanner, J | 1 |
| Fidock, DA; Flannery, EL; Winzeler, EA | 1 |
| Avery, VM; Baell, JB; Ban, K; Beveridge, JG; Blundell, S; Charman, SA; Chavchich, M; Chiu, FCK; Creek, D; Cuellar, ME; Dahlin, JL; Diab, S; Dingjan, T; Duffy, S; Edstein, MD; Ellis, K; Fletcher, S; Harjani, JR; Huang, F; Lucantoni, L; Marfurt, J; Noviyanti, R; Price, RN; Ralph, SA; Shi, DH; Strasser, JM; Teguh, S; Walters, MA; Wirjanata, G; Xue, L | 1 |
| Bane, CE; Black, C; Butler, K; Caridha, D; Cooper, RA; Dodean, RA; Gaona, H; Gaynor-Ohnstad, L; Huezo, SJ; Kancharla, P; Kelly, JX; Kreishman-Deitrick, M; Leed, SE; Li, Q; Li, Y; Lin, H; Luong, TL; Marcsisin, S; Melendez, V; Nolan, C; Olmeda, R; Potter, B; Pou, S; Rasmussen, SA; Read, L; Riscoe, MK; Roncal, N; Sciotti, RJ; Smilkstein, MJ; Sousa, J; Stephens, MT; Tan, JC; Vesely, B; Vuong, C; Winter, RW; Xie, L; Zeng, Q; Zhang, J; Zhang, P | 1 |
| Ashton, TD; Burrows, JN; Charman, SA; Creek, DJ; Devine, SM; Laleu, B; Möhrle, JJ; Sleebs, BE | 1 |
| Huang, QL; Wu, Z; Zhang, KY; Zhou, JX | 1 |
| Coulanges, P; Deloron, P; Le Bras, J; Ramanamirija, JA | 1 |
| Li, GD | 1 |
| Huang, K; Liao, M; Liu, D; Yang, H; Yang, P; Yang, Y; Zhang, C | 1 |
| Chalermrut, K; Krudsood, S; Looareesuwan, S; Pengruksa, C; Silachamroon, U; Srivilairit, S; Treeprasertsuk, S; Wilairatana, P | 1 |
| Ashley, EA; Brockman, A; Hutagalung, R; Krudsood, S; Leowattana, W; Looareesuwan, S; McGready, R; Nosten, F; Phaiphun, L; Srivilairit, S; White, NJ; Wilairatana, P | 1 |
| Ashley, EA; Barends, M; Hutagalung, R; Looareesuwan, S; McGready, R; Nosten, F; Phaiphun, L; Proux, S; Slight, T; Thwai, KL; White, NJ | 1 |
| Chalermrut, K; Kano, S; Krudsood, S; Looareesuwan, S; Pengruksa, C; Phongtananant, S; Silachamroon, U; Srivilairit, S; Tangpukdee, N; Thanachartwet, W; Wilairatana, P | 1 |
| Duffy, PE; Mutabingwa, TK | 1 |
| Ashley, E; Aye, KZ; Barends, M; Htet, L; Kyaw, MK; Lindegardh, N; Lwin, S; Phe, O; Singtoroj, T; Smithuis, F; Stepniewska, K; White, NJ | 1 |
| Barends, M; Keola, S; Khanthavong, M; Lindegårdh, N; Mayxay, M; Newton, PN; Phetsouvanh, R; Phompida, S; Pongvongsa, T; Stepniewska, K; Thongpraseuth, V; White, NJ | 1 |
| Ashley, EA; Brockman, A; Chan, S; Goubert, L; Janssens, B; Nong, S; Socheat, D; Uong, S; Van Damme, W; van Herp, M | 1 |
| Bernasconi, A; Casapia, M; D'Alessandro, U; Delgado, C; Erhart, A; Fanello, C; Gamboa, D; Grande, T; Llanos-Cuentas, A; Torres, K | 1 |
| Brittenham, GM; Kano, S; Krudsood, S; Li, G; Looareesuwan, S; Pengruksa, C; Phophak, N; Tangpukdee, N; Thanachartwet, V; Wilairatana, P | 1 |
| Donegan, S; Garner, P; Olliaro, P; Sinclair, D; Zani, B | 1 |
| Davis, TM; Hackett, SL; Ilett, KF; Karunajeewa, HA; Lautu, D; Mueller, I; Siba, P; Tavul, L; Wong, RP | 1 |
| Bacchieri, A; Bhattacharya, PC; Corsi, M; Dev, V; Dubhashi, N; Duparc, S; Ghosh, SK; Keomany, S; Khanthavong, M; Krudsood, S; Kumar, A; Mayxay, M; Newton, PN; Phyo, AP; Pongvongsa, T; Pukittayakamee, S; Pukrittayakamee, S; Rao, BH; Ruangveerayuth, R; Ubben, D; Uthaisil, C; Valecha, N | 1 |
| Ariey, F; Beck, HP; Decosterd, LA; Duong, S; Genton, B; Hodel, EM; Mercier, T; Olliaro, P; Zanolari, B | 1 |
| Keola, S; Keomany, S; Khanthavong, M; Khomthilath, T; Mayxay, M; Newton, PN; Phompida, S; Pongvongsa, T; Souvannasing, P; Stepniewska, K; Ubben, D; Valecha, N; White, NJ | 1 |
| Bentura-Marciano, A; Chan, WC; Clark, J; Golenser, J; Guiguemde, AW; Guo, J; Guy, RK; Haynes, RK; Hunt, NH; Wong, HN | 1 |
| Bacchieri, A; Bhattacharyya, PC; Corsi, M; Dev, V; Dubashi, N; Gargano, N; Ghosh, SK; Kumar, A; Rao, BH; Srivastava, B; Tommasini, S; Ubben, D; Valecha, N | 1 |
| Charman, SA; Gamo-Benito, J; Humberstone, A; Jamsen, KM; McCaw, J; Moehrle, J; Price, RN; Simpson, JA; Smith, K; Zaloumis, S | 1 |
| Abdur, R; Barrette, A; Bouth, DM; Duong, S; Leang, R; Menard, D; Ringwald, P | 1 |
| Ariey, F; Beck, HP; Csajka, C; Decosterd, LA; Duong, S; Genton, B; Guidi, M; Kabanywanyi, AM; Olliaro, P; Staehli Hodel, EM | 1 |
| Beeson, JG; Goodman, CD; Langer, C; McFadden, GI; Wilson, DW | 1 |
| Ariey, F; Beck, HP; Buclin, T; Csajka, C; Decosterd, LA; Duong, S; Genton, B; Guidi, M; Kabanywanyi, AM; Mercier, T; Olliaro, P; Staehli Hodel, EM; Zanolari, B | 1 |
| Burkholder, B; Bustos, MD; Delacollette, C; Wongsrichanalai, C | 1 |
| Donegan, S; Gathu, M; Olliaro, PL; Sinclair, D; Zani, B | 1 |
| Dahlstrom, S; Ferreira, PE; Franzén, O; Gil, JP; Lum, JK; Nosten, F; Osório, NS; Veiga, MI | 1 |
| Claeys, Y; D'Alessandro, U; De Crop, M; Halidou, T; Kalanda, G; Menten, J; Mulenga, M; Mutabingwa, T; Mwakazanga, D; Mwapasa, V; Nambozi, M; Phiri, LK; Ravinetto, R; Schurmans, C; Tagbor, H; Thriemer, K; Traore, M; Valea, I; Van Geertruyden, JP | 1 |
| Buathong, N; Chanarat, N; Chann, S; Chaorattanakawee, S; Chuor, CM; Gosi, P; Heng, TK; Jacob, C; Kong, N; Kuntawunginn, W; Lanteri, CA; Lin, JT; Lon, C; Plowe, C; Prom, S; Saingam, P; Saunders, DL; Se, Y; Sea, D; Sriwichai, S; Sundrakes, S; Takala-Harrison, S; Tangthongchaiwiriya, K; Teja-Isavadharm, P; Tyner, SD; Yingyuen, K; Yom, Y | 1 |
| Bouth, DM; Char, MC; Domergue, A; Duru, V; Khim, N; Kim, S; Leang, R; Menard, D; Ringwald, P; Song, L; Tarning, J; Taylor, WR; Witkowski, B | 1 |
| Hastings, IM; Hodel, EM; Kay, K | 1 |
| Cabrera, M; Cui, L | 1 |
| Auburn, S; Handayuni, I; Marfurt, J; Noviyanti, R; Pava, Z; Poespoprodjo, JR; Price, RN; To, S; Trianty, L; Wirjanata, G | 1 |
| Maxmen, A | 1 |
| Amalvict, R; Benoit, N; Diatta, B; Diawara, S; Diémé, Y; Fall, B; Fall, M; Gendrot, M; Madamet, M; Nakoulima, A; Pradines, B; Wade, B; Wade, KA | 1 |
| Bethell, D; Buathong, N; Chann, S; Chaorattanakawee, S; Chattrakarn, S; Fukuda, MM; Gawee, J; Huy, R; Jongsakul, K; Kong, N; Lanteri, C; Lon, C; Praditpol, C; Prom, S; Saunders, D; Sirisopana, N; Smith, P; Sok, S; Sundrakes, S; Thamnurak, C; Uthaimongkol, N; Walsh, DS | 1 |
| Liu, XJ; Peng, HJ; Wei, HX; Xia, J; Zhou, LJ | 1 |
| Amalvict, R; Benoit, N; Briolant, S; Diatta, B; Diawara, S; Diémé, Y; Fall, B; Fall, M; Gendrot, M; Kounta, MB; Madamet, M; Nakoulima, A; Pradines, B; Wade, B; Wade, KA | 1 |
| Buyze, J; D'Alessandro, U; Hachizovu, S; Kabuya, JB; Kasongo, W; Mulenga, J; Mulenga, M; Mwakazanga, D; Nambozi, M; Van Geertruyden, JP | 1 |
| Bailey, JA; Barnett, EJ; Brazeau, NF; Chaorattanakawee, S; Gosi, P; Juliano, JJ; Lanteri, CA; Lin, JT; Lon, C; Meshnick, SR; Norris, LD; Parobek, CM; Parr, JB; Saunders, DL; Spring, MD | 1 |
| Byaruhanga, O; Ceja, FG; Conrad, MD; Cooper, RA; Katairo, T; Nsobya, SL; Rasmussen, SA; Rosenthal, PJ; Tumwebaze, PK | 1 |
| Agarwal, P; Anvikar, AR; Pillai, CR; Srivastava, K | 1 |
| Cao, P; Dini, S; Fowkes, FJI; McCaw, JM; Price, RN; Simpson, JA; van der Pluijm, RW; Zaloumis, S | 1 |
| Cao, P; Cromer, D; Davenport, MP; Dini, S; Fowkes, FJI; Khoury, DS; McCaw, JM; Simpson, JA; Zaloumis, SG | 1 |
| Chotivanich, K; Dondorp, AM; Hanboonkunupakarn, B; Hoglund, R; Jittamala, P; Mukaka, M; Pukrittayakamee, S; Singhasivanon, P; Tarning, J; van der Pluijm, RW; Waithira, N; White, NJ; Winterberg, M | 1 |
| Chy, S; Felger, I; Hastings, I; Hodel, EM; Jones, S; Kay, K; Mbituyumuremyi, A; Menard, D; Uwimana, A | 1 |
| Amaratunga, C; Amato, R; Ashley, EA; Chau, NH; Cheah, PY; Chotivanich, K; Chutasmit, K; Day, NP; Dhorda, M; Dondorp, AM; Fairhurst, RM; Gonçalves, S; Hamilton, WL; Hanboonkunupakarn, B; Hien, TT; Hoa, NT; Huy, R; Imwong, M; Jacob, CG; Jittamala, P; Kaewmok, W; Kwiatkowski, DP; Lek, D; Mao, S; Maude, RJ; Miotto, O; Mukaka, M; Oun, S; Pearson, RD; Peto, TJ; Pukrittayakamee, S; Runjarern, R; Saelow, C; Sreng, S; Suon, S; Tarning, J; Thanh, NV; Thuy-Nhien, NT; Tripura, R; van der Pluijm, RW; Waithira, N; White, NJ; Winterberg, M; Yen, S; Yok, S | 1 |
| Amaratunga, C; Amato, R; Anvikar, AR; Ashley, E; Baidya, S; Behera, PK; Callery, JJ; Chau, NH; Cheah, PY; Chotivanich, K; Chutasmit, K; Day, NPJ; Dhorda, M; Dondorp, AM; Fairhurst, RM; Faiz, A; Fanello, C; Gantait, K; Ghosh, T; Gonçalves, S; Grobusch, MP; Hanboonkunupakarn, B; Heaton, J; Hien, TT; Hlaing, TM; Hoa, NT; Hoglund, RM; Huy, R; Imwong, M; Jacob, CG; Jittamala, P; Kaewmok, W; Kwiatkowski, DP; Lek, D; Lin, K; Mao, S; Maude, RJ; Mayxay, M; Miotto, O; Mohanty, AK; Mukaka, M; Newton, PN; Onyamboko, M; Oun, S; Pearson, RD; Peto, TJ; Pukrittayakamee, S; Pyae Phyo, A; Runcharern, R; Saelow, C; Satpathi, P; Satpathi, S; Smithuis, F; Sovann, Y; Sreng, S; Suon, S; Tarning, J; Thanh, NV; Thant, M; Thuy-Nhien, NT; Tripura, A; Tripura, R; Ul Islam, A; Valecha, N; van der Pluijm, RW; van Vugt, M; von Seidlein, L; Waithira, N; White, NJ; Winterberg, M; Woodrow, CJ; Yen, S | 1 |
| Kim, S; Lek, D; Mairet-Khedim, M; Popovici, J; Roesch, C; Witkowski, B | 1 |
| Anvikar, AR; Ashley, EA; Chandramohan, D; Cohee, LM; D'Alessandro, U; Genton, B; Gilder, ME; Guérin, PJ; Juma, E; Kalilani-Phiri, L; Kennon, K; Kuepfer, I; Laufer, MK; Lwin, KM; Mansoor, R; McGready, R; Meshnick, SR; Mosha, D; Mwapasa, V; Mwebaza, N; Nambozi, M; Ndiaye, JA; Nosten, F; Nyunt, M; Ogutu, B; Parikh, S; Paw, MK; Phyo, AP; Pimanpanarak, M; Piola, P; Rijken, MJ; Saito, M; Sriprawat, K; Stepniewska, K; Tagbor, HK; Tarning, J; Tinto, H; Valéa, I; Valecha, N; White, NJ; Wiladphaingern, J | 1 |
| Bah, S; Dabitao, D; Dama, S; Diakité, M; Diakité, SAS; Doumbia, S; Doumbouya, M; Guindo, MA; Keita, B; Konaté, DS; Sangaré, M; Sanogo, I; Traoré, K | 1 |
| Adams, M; Boonyalai, N; Chaisatit, C; Chann, S; Chaorattanakawee, S; Deutsch-Feldman, M; Gosi, P; Lanteri, CA; Lek, D; Lertsethtakarn, P; Lin, JT; Lon, C; Morgan, AP; Praditpol, C; Rekol, H; Saingam, P; Satharath, P; Saunders, DL; Sea, D; Shah, Z; Shrestha, B; Smith, PL; Sok, S; Spring, MD; Takala-Harrison, S; Tyner, SD; Vesely, BA; Waters, NC; Wojnarski, M | 1 |
| Andersen, JF; Coonahan, ES; De Vos, M; Fay, MP; Long, CA; Pecic, S; Tarning, J; Wellems, TE; Yang, KA | 1 |
| Hughes, E; Jagannathan, P; Mohamed Ali, A; Savic, RM; Wallender, E | 1 |
| Bancone, G; Carrara, VI; Chu, C; Duanguppama, J; Gilder, ME; Haohankhunnatham, W; Imwong, M; Konghahong, K; Lee, SJ; McGready, R; Min, AM; Nosten, F; Paw, MK; Phyo, AP; Pimanpanarak, M; Proux, S; Saito, M; Singhasivanon, P; Tun, NW; Turner, C; Viladpai-Nguen, J; White, NJ | 1 |
| Bassat, Q; Varo, R | 1 |
| Bejon, P; Boga, M; Day, NPJ; Dhorda, M; Dondorp, AM; Gonçalves, S; Hamaluba, M; Hoglund, RM; Imwong, M; Kalume, P; Khuroo, A; Lal, AA; Miotto, O; Mturi, N; Mukaka, M; Mutinda, B; Mwambingu, G; Ngama, M; Ngetsa, C; Njuguna, P; Tarning, J; Taylor, WRJ; van der Pluijm, RW; Waithira, N; Wambua, J; Weya, J; White, NJ | 1 |
| Barale, JC; Bouillon, A; Chy, S; Eam, R; Kauy, C; Ke, S; Khean, C; Khim, N; Kim, S; Kloeung, N; Kul, C; Leang, R; Mairet-Khedim, M; Ringwald, P; Roesch, C; Srun, S; Witkowski, B | 1 |
9 review(s) available for piperaquine and mefloquine
| Article | Year |
|---|---|
Recent advances in malaria drug discovery.
Topics: Animals; Antimalarials; Drug Discovery; Humans; Liver; Liver Transplantation; Malaria; Molecular Structure | 2013 |
Using genetic methods to define the targets of compounds with antimalarial activity.
Topics: Animals; Anopheles; Antimalarials; Drug Resistance; Genetic Association Studies; Genome, Protozoan; Humans; Malaria, Falciparum; Molecular Targeted Therapy; Plasmodium falciparum | 2013 |
The Development Process for Discovery and Clinical Advancement of Modern Antimalarials.
Topics: Antimalarials; Drug Discovery; Humans; Malaria; Molecular Structure; Plasmodium | 2019 |
Artemisinin-based combination therapy for treating uncomplicated malaria.
Topics: Antimalarials; Artemisinins; Artesunate; Drug Combinations; Drug Therapy, Combination; Ethanolamines; Fluorenes; Humans; Lumefantrine; Malaria; Malaria, Falciparum; Malaria, Vivax; Mefloquine; Parasitemia; Pyrimethamine; Quinolines; Randomized Controlled Trials as Topic; Sulfadoxine | 2009 |
Monitoring antimalarial drug efficacy in the Greater Mekong Subregion: an overview of in vivo results from 2008 to 2010.
Topics: Antimalarials; Artemether; Artemisinins; Artesunate; Asia, Southeastern; Chloroquine; Directly Observed Therapy; Drug Resistance; Drug Therapy, Combination; Ethanolamines; Fluorenes; Humans; Lumefantrine; Malaria, Falciparum; Malaria, Vivax; Mefloquine; Parasitemia; Quinolines | 2013 |
Dihydroartemisinin-piperaquine for treating uncomplicated Plasmodium falciparum malaria.
Topics: Adult; Antimalarials; Artemether, Lumefantrine Drug Combination; Artemisinins; Artesunate; Child; Drug Combinations; Drug Therapy, Combination; Ethanolamines; Fluorenes; Humans; Malaria, Falciparum; Mefloquine; Parasitemia; Quinolines; Randomized Controlled Trials as Topic | 2014 |
Risk of drug resistance in Plasmodium falciparum malaria therapy-a systematic review and meta-analysis.
Topics: Amodiaquine; Antimalarials; Artemisinins; Chloroquine; Drug Combinations; Drug Resistance; Drug Therapy, Combination; Humans; Malaria, Falciparum; Mefloquine; Plasmodium falciparum; Pyrimethamine; Quinolines; Risk; Sulfadoxine | 2017 |
Efficacy and tolerability of artemisinin-based and quinine-based treatments for uncomplicated falciparum malaria in pregnancy: a systematic review and individual patient data meta-analysis.
Topics: Amodiaquine; Anti-Bacterial Agents; Antimalarials; Artemisinins; Artesunate; Atovaquone; Clindamycin; Drug Combinations; Drug Therapy, Combination; Female; Humans; Malaria, Falciparum; Mefloquine; Pregnancy; Pregnancy Complications, Parasitic; Proguanil; Pyrimethamine; Quinine; Quinolines; Sulfadoxine | 2020 |
Malaria PK/PD and the Role Pharmacometrics Can Play in the Global Health Arena: Malaria Treatment Regimens for Vulnerable Populations.
Topics: Amodiaquine; Anti-HIV Agents; Antimalarials; Artemether, Lumefantrine Drug Combination; Artemisinins; Artesunate; Child, Preschool; Dose-Response Relationship, Drug; Drug Combinations; Drug Interactions; Drug Therapy, Combination; Female; Global Health; HIV Infections; Humans; Malaria; Malnutrition; Mefloquine; Models, Biological; Pregnancy; Pregnancy Complications, Parasitic; Pyrimethamine; Quinolines; Sulfadoxine; Vulnerable Populations | 2021 |
22 trial(s) available for piperaquine and mefloquine
| Article | Year |
|---|---|
An open randomized clinical trial of Artecom vs artesunate-mefloquine in the treatment of acute uncomplicated falciparum malaria in Thailand.
Topics: Adolescent; Adult; Aged; Antimalarials; Artemisinins; Artesunate; Child; Drug Combinations; Drug Resistance, Multiple; Female; Humans; Malaria, Falciparum; Male; Mefloquine; Middle Aged; Quinolines; Sesquiterpenes; Thailand; Trimethoprim | 2002 |
Randomized, controlled dose-optimization studies of dihydroartemisinin-piperaquine for the treatment of uncomplicated multidrug-resistant falciparum malaria in Thailand.
Topics: Adolescent; Adult; Animals; Antimalarials; Artemisinins; Artesunate; Child; Child, Preschool; Drug Combinations; Drug Resistance, Multiple; Drug Therapy, Combination; Female; Humans; Infant; Malaria, Falciparum; Male; Mefloquine; Middle Aged; Plasmodium falciparum; Quinolines; Sesquiterpenes; Thailand | 2004 |
A randomized, controlled study of a simple, once-daily regimen of dihydroartemisinin-piperaquine for the treatment of uncomplicated, multidrug-resistant falciparum malaria.
Topics: Adolescent; Adult; Aged; Animals; Antimalarials; Artemisinins; Artesunate; Child; Child, Preschool; Drug Combinations; Drug Resistance, Multiple; Female; Humans; Infant; Malaria, Falciparum; Male; Mefloquine; Middle Aged; Plasmodium falciparum; Quinolines; Sesquiterpenes | 2005 |
An open randomized clinical trial of Artekin vs artesunate-mefloquine in the treatment of acute uncomplicated falciparum malaria.
Topics: Acute Disease; Adolescent; Adult; Antimalarials; Artemisinins; Artesunate; Drug Combinations; Female; Humans; Malaria, Falciparum; Male; Mefloquine; Quinolines; Sesquiterpenes; Thailand; Treatment Outcome | 2005 |
Efficacy and effectiveness of dihydroartemisinin-piperaquine versus artesunate-mefloquine in falciparum malaria: an open-label randomised comparison.
Topics: Adolescent; Animals; Antimalarials; Artemisinins; Artesunate; Child; Child, Preschool; Drug Therapy, Combination; Female; Humans; Infant; Malaria, Falciparum; Male; Mefloquine; Myanmar; Plasmodium falciparum; Quinolines; Recurrence; Sesquiterpenes; Treatment Outcome | 2006 |
An open, randomized comparison of artesunate plus mefloquine vs. dihydroartemisinin-piperaquine for the treatment of uncomplicated Plasmodium falciparum malaria in the Lao People's Democratic Republic (Laos).
Topics: Administration, Oral; Adolescent; Adult; Antimalarials; Artemisinins; Artesunate; Child; Drug Therapy, Combination; Female; Humans; Laos; Malaria, Falciparum; Male; Mefloquine; Parasitemia; Quinolines; Recurrence; Sesquiterpenes; Treatment Failure; Treatment Outcome | 2006 |
A randomized open study to assess the efficacy and tolerability of dihydroartemisinin-piperaquine for the treatment of uncomplicated falciparum malaria in Cambodia.
Topics: Adolescent; Adult; Aged; Anemia; Antimalarials; Artemisinins; Artesunate; Cambodia; Child; Child, Preschool; Drug Therapy, Combination; Female; Genome, Protozoan; Humans; Infant; Malaria, Falciparum; Malaria, Vivax; Male; Mefloquine; Middle Aged; Quinolines; Recurrence; Sesquiterpenes; Treatment Outcome | 2007 |
A randomised controlled trial to assess the efficacy of dihydroartemisinin-piperaquine for the treatment of uncomplicated falciparum malaria in Peru.
Topics: Adolescent; Adult; Antimalarials; Artemisinins; Artesunate; Child; Child, Preschool; Female; Humans; Malaria, Falciparum; Male; Mefloquine; Middle Aged; Peru; Quinolines; Sesquiterpenes | 2007 |
Efficacy of Artequick versus artesunate-mefloquine in the treatment of acute uncomplicated falciparum malaria in Thailand.
Topics: Acute Disease; Adolescent; Adult; Antimalarials; Artemisinins; Artesunate; Drug Combinations; Female; Humans; Malaria, Falciparum; Male; Mefloquine; Middle Aged; Primaquine; Prospective Studies; Quinolines; Thailand; Treatment Outcome | 2008 |
An open-label, randomised study of dihydroartemisinin-piperaquine versus artesunate-mefloquine for falciparum malaria in Asia.
Topics: Adolescent; Adult; Aged; Antimalarials; Artemisinins; Artesunate; Asia; Child; Child, Preschool; Female; Humans; Infant; Malaria, Falciparum; Male; Mefloquine; Middle Aged; Quinolines; Young Adult | 2010 |
A phase III, randomized, non-inferiority trial to assess the efficacy and safety of dihydroartemisinin-piperaquine in comparison with artesunate-mefloquine in patients with uncomplicated Plasmodium falciparum malaria in southern Laos.
Topics: Adolescent; Adult; Antimalarials; Artemisinins; Artesunate; Child; Child, Preschool; Drug Therapy, Combination; Female; Humans; Laos; Malaria, Falciparum; Male; Mefloquine; Quinolines; Young Adult | 2010 |
Therapeutic efficacy and safety of dihydroartemisinin-piperaquine versus artesunate-mefloquine in uncomplicated Plasmodium falciparum malaria in India.
Topics: Adolescent; Adult; Aged; Antimalarials; Artemisinins; Artesunate; Asia; Drug Therapy, Combination; Drug-Related Side Effects and Adverse Reactions; Female; Humans; India; Malaria, Falciparum; Male; Mefloquine; Middle Aged; Quinolines; Treatment Outcome; Young Adult | 2012 |
Safe and efficacious artemisinin-based combination treatments for African pregnant women with malaria: a multicentre randomized control trial.
Topics: Adult; Amodiaquine; Antimalarials; Artemether, Lumefantrine Drug Combination; Artemisinins; Artesunate; Birth Weight; Burkina Faso; Drug Combinations; Ethanolamines; Female; Fetal Development; Fluorenes; Follow-Up Studies; Ghana; Humans; Infant, Newborn; Malaria; Malawi; Mefloquine; Placentation; Pregnancy; Pregnancy Complications, Parasitic; Prenatal Exposure Delayed Effects; Quinolines; Zambia | 2015 |
Evidence of Plasmodium falciparum Malaria Multidrug Resistance to Artemisinin and Piperaquine in Western Cambodia: Dihydroartemisinin-Piperaquine Open-Label Multicenter Clinical Assessment.
Topics: Adolescent; Adult; Antigens, Bacterial; Antigens, Surface; Antimalarials; Artemisinins; Cambodia; Child; Child, Preschool; Drug Resistance, Multiple; Drug Therapy, Combination; Female; Humans; Malaria, Falciparum; Male; Mefloquine; Middle Aged; Plasmodium falciparum; Quinolines; Treatment Failure; Young Adult | 2015 |
Ex vivo piperaquine resistance developed rapidly in Plasmodium falciparum isolates in northern Cambodia compared to Thailand.
Topics: Antigens, Protozoan; Antimalarials; Artemisinins; Cambodia; Drug Resistance; Humans; Inhibitory Concentration 50; Mefloquine; Parasitic Sensitivity Tests; Plasmodium falciparum; Protozoan Proteins; Quinolines; Thailand | 2016 |
Artemisinin-based combination therapy in pregnant women in Zambia: efficacy, safety and risk of recurrent malaria.
Topics: Adolescent; Adult; Antimalarials; Artemether, Lumefantrine Drug Combination; Artemisinins; Artesunate; Drug Combinations; Ethanolamines; Female; Fluorenes; Humans; Malaria; Mefloquine; Pregnancy; Quinolines; Recurrence; Risk; Treatment Outcome; Young Adult; Zambia | 2017 |
Changing Antimalarial Drug Sensitivities in Uganda.
Topics: Adolescent; Amodiaquine; Antimalarials; Artemisinins; Aspartic Acid Endopeptidases; Child; Child, Preschool; Chloroquine; Drug Resistance; Ethanolamines; Female; Fluorenes; Gene Expression; Humans; Infant; Inhibitory Concentration 50; Lumefantrine; Malaria, Falciparum; Male; Mefloquine; Membrane Transport Proteins; Multidrug Resistance-Associated Proteins; Mutation; Parasitic Sensitivity Tests; Plasmodium falciparum; Protozoan Proteins; Quinolines; Uganda; Young Adult | 2017 |
Sequential Open-Label Study of the Safety, Tolerability, and Pharmacokinetic Interactions between Dihydroartemisinin-Piperaquine and Mefloquine in Healthy Thai Adults.
Topics: Adult; Antimalarials; Artemisinins; Cardiotoxicity; Dizziness; Female; Healthy Volunteers; Humans; Male; Mefloquine; Middle Aged; Nausea; Quinolines; Thailand | 2019 |
Determinants of dihydroartemisinin-piperaquine treatment failure in Plasmodium falciparum malaria in Cambodia, Thailand, and Vietnam: a prospective clinical, pharmacological, and genetic study.
Topics: Adolescent; Adult; Antimalarials; Artemisinins; Cambodia; Drug Resistance, Multiple; Drug Therapy, Combination; Female; High-Throughput Nucleotide Sequencing; Humans; Malaria, Falciparum; Male; Mefloquine; Membrane Transport Proteins; Middle Aged; Mutation; Plasmodium falciparum; Prospective Studies; Protozoan Proteins; Quinolines; Thailand; Treatment Failure; Vietnam; Young Adult | 2019 |
Triple artemisinin-based combination therapies versus artemisinin-based combination therapies for uncomplicated Plasmodium falciparum malaria: a multicentre, open-label, randomised clinical trial.
Topics: Adolescent; Adult; Amodiaquine; Anthraquinones; Antimalarials; Artemether, Lumefantrine Drug Combination; Artemisinins; Drug Resistance; Drug Therapy, Combination; Female; Humans; Malaria, Falciparum; Male; Mefloquine; Plasmodium falciparum; Polymerase Chain Reaction; Quinolines; Treatment Outcome; Young Adult | 2020 |
A randomized controlled trial of dihydroartemisinin-piperaquine, artesunate-mefloquine and extended artemether-lumefantrine treatments for malaria in pregnancy on the Thailand-Myanmar border.
Topics: Antimalarials; Artemether; Artemether, Lumefantrine Drug Combination; Artemisinins; Artesunate; Drug Therapy, Combination; Female; Humans; Infant, Newborn; Malaria; Malaria, Falciparum; Mefloquine; Myanmar; Pregnancy; Premature Birth; Quinolines; Thailand | 2021 |
Arterolane-piperaquine-mefloquine versus arterolane-piperaquine and artemether-lumefantrine in the treatment of uncomplicated Plasmodium falciparum malaria in Kenyan children: a single-centre, open-label, randomised, non-inferiority trial.
Topics: Administration, Oral; Antimalarials; Artemether, Lumefantrine Drug Combination; Child; Child, Preschool; Female; Heterocyclic Compounds, 1-Ring; Humans; Kenya; Malaria, Falciparum; Male; Mefloquine; Peroxides; Plasmodium falciparum; Quinolines; Spiro Compounds; Treatment Outcome | 2021 |
34 other study(ies) available for piperaquine and mefloquine
| Article | Year |
|---|---|
3,3'-Disubstituted 5,5'-Bi(1,2,4-triazine) Derivatives with Potent in Vitro and in Vivo Antimalarial Activity.
Topics: Animals; Antimalarials; Chloroquine; Drug Resistance; Humans; In Vitro Techniques; Magnetic Resonance Spectroscopy; Mice; Molecular Structure; Plasmodium; Species Specificity; Structure-Activity Relationship; Triazines | 2019 |
Discovery and Structural Optimization of Acridones as Broad-Spectrum Antimalarials.
Topics: Acridones; Animals; Antimalarials; Disease Models, Animal; Drug Discovery; Hep G2 Cells; Humans; Malaria; Mice; Plasmodium; Species Specificity; Structure-Activity Relationship | 2019 |
[Susceptibility of Plasmodium falciparum to chloroquine, piperaquine, amodiaquine, mefloquine and quinine with in vitro microtechnique in Hainan Island].
Topics: Amodiaquine; Animals; Antimalarials; Chloroquine; Drug Resistance; Drug Synergism; Mefloquine; Plasmodium falciparum; Quinolines | 1987 |
Plasmodium falciparum in Madagascar: in vivo and in vitro sensitivity to seven drugs.
Topics: Adolescent; Adult; Aged; Amodiaquine; Antimalarials; Child; Child, Preschool; Chloroquine; Humans; Infant; Madagascar; Malaria; Mefloquine; Microbial Sensitivity Tests; Middle Aged; Phenanthrenes; Piperazines; Plasmodium falciparum; Quinine; Quinolines | 1985 |
[Development of a piperaquine-resistant line of Plasmodium berghei K 173 strain].
Topics: Animals; Antimalarials; Artemisinins; Artesunate; Chloroquine; Drug Resistance; Malaria; Male; Mefloquine; Mice; Plasmodium berghei; Quinolines; Sesquiterpenes | 1985 |
[Assay of sensitivity of Plasmodium falciparum to chloroquine, amodiaquine, piperaquine, mefloquine and quinine in Yunnan province].
Topics: Amodiaquine; Animals; Antimalarials; Chloroquine; Drug Resistance; Mefloquine; Plasmodium falciparum; Quinine; Quinolines | 1999 |
Artemisinin combination therapies.
Topics: Adult; Africa; Antimalarials; Artemisinins; Artesunate; Asia; Child, Preschool; Drug Therapy, Combination; Humans; Malaria, Falciparum; Mefloquine; Quinolines; Sesquiterpenes | 2006 |
In vitro sensitivity of Plasmodium falciparum to conventional and novel antimalarial drugs in Papua New Guinea.
Topics: Amodiaquine; Antimalarials; Artemisinins; Azithromycin; Child; Child, Preschool; Drug Resistance, Multiple; Female; Humans; Infant; Inhibitory Concentration 50; L-Lactate Dehydrogenase; Male; Mefloquine; Membrane Transport Proteins; Naphthoquinones; Plasmodium falciparum; Protozoan Proteins; Quinolines; Threshold Limit Values | 2010 |
Residual antimalarial concentrations before treatment in patients with malaria from Cambodia: indication of drug pressure.
Topics: Adolescent; Adult; Antimalarials; Cambodia; Child; Child, Preschool; Chloroquine; Chromatography, Liquid; Drug Resistance; Female; Humans; Malaria, Falciparum; Male; Mefloquine; Middle Aged; Quinine; Quinolines; Selection, Genetic; Serum; Tandem Mass Spectrometry; Young Adult | 2010 |
Synthesis of artemiside and its effects in combination with conventional drugs against severe murine malaria.
Topics: Animals; Antimalarials; Artemisinins; Disease Models, Animal; Drug Administration Schedule; Drug Synergism; Drug Therapy, Combination; High-Throughput Screening Assays; Humans; Inhibitory Concentration 50; Malaria, Cerebral; Malaria, Falciparum; Mefloquine; Mice; Mice, Inbred C57BL; Microscopy; Parasitemia; Plasmodium berghei; Plasmodium falciparum; Quinolines; Secondary Prevention; Survival Rate | 2012 |
Assessing the utility of an anti-malarial pharmacokinetic-pharmacodynamic model for aiding drug clinical development.
Topics: Animals; Antimalarials; Artemether, Lumefantrine Drug Combination; Artemisinins; Artesunate; Dose-Response Relationship, Drug; Drug Combinations; Drug Discovery; Ethanolamines; Fluorenes; Host-Pathogen Interactions; Humans; Malaria, Falciparum; Mefloquine; Models, Statistical; Plasmodium falciparum; Quinolines | 2012 |
Efficacy of dihydroartemisinin-piperaquine for treatment of uncomplicated Plasmodium falciparum and Plasmodium vivax in Cambodia, 2008 to 2010.
Topics: Adolescent; Adult; Antimalarials; Artemisinins; Cambodia; Child; Chloroquine; Drug Resistance; Drug Therapy, Combination; Female; Genotype; Humans; Malaria, Falciparum; Malaria, Vivax; Male; Mefloquine; Membrane Transport Proteins; Middle Aged; Parasitic Sensitivity Tests; Plasmodium falciparum; Plasmodium vivax; Protozoan Proteins; Quinolines; Treatment Outcome; Young Adult | 2013 |
Effect of single nucleotide polymorphisms in cytochrome P450 isoenzyme and N-acetyltransferase 2 genes on the metabolism of artemisinin-based combination therapies in malaria patients from Cambodia and Tanzania.
Topics: Alleles; Antimalarials; Artemether, Lumefantrine Drug Combination; Artemisinins; Artesunate; Arylamine N-Acetyltransferase; Base Sequence; Cambodia; Cytochrome P-450 Enzyme System; Drug Combinations; Ethanolamines; Fluorenes; Gene Frequency; Humans; Isoenzymes; Malaria; Mefloquine; Pharmacogenetics; Polymorphism, Single Nucleotide; Quinolines; Sequence Analysis, DNA; Tanzania | 2013 |
Defining the timing of action of antimalarial drugs against Plasmodium falciparum.
Topics: Amodiaquine; Antimalarials; Artemisinins; Artesunate; Chloroquine; Erythrocytes; Flow Cytometry; High-Throughput Screening Assays; Hydroxamic Acids; Inhibitory Concentration 50; Mefloquine; Merozoites; Plasmodium falciparum; Quinine; Quinolines; Schizonts; Time Factors | 2013 |
Population pharmacokinetics of mefloquine, piperaquine and artemether-lumefantrine in Cambodian and Tanzanian malaria patients.
Topics: Adolescent; Adult; Aged; Antimalarials; Artemether, Lumefantrine Drug Combination; Artemisinins; Cambodia; Child; Child, Preschool; Drug Combinations; Ethanolamines; Female; Fluorenes; Humans; Infant; Malaria; Male; Mefloquine; Middle Aged; Plasma; Quinolines; Tanzania; Young Adult | 2013 |
Complex polymorphisms in the Plasmodium falciparum multidrug resistance protein 2 gene and its contribution to antimalarial response.
Topics: Amino Acid Sequence; Antimalarials; Artemisinins; Biological Transport; Chloroquine; Chromosomes; Drug Resistance, Multiple; Erythrocytes; Humans; INDEL Mutation; Malaria, Falciparum; Mefloquine; Molecular Sequence Data; Multidrug Resistance-Associated Proteins; Parasitic Sensitivity Tests; Plasmodium falciparum; Polymorphism, Single Nucleotide; Quinolines; Thailand | 2014 |
Ex Vivo Drug Susceptibility Testing and Molecular Profiling of Clinical Plasmodium falciparum Isolates from Cambodia from 2008 to 2013 Suggest Emerging Piperaquine Resistance.
Topics: Adolescent; Adult; Aged; Antimalarials; Artemisinins; Cambodia; Chloroquine; Drug Resistance; Female; Humans; Inhibitory Concentration 50; Malaria, Falciparum; Male; Mefloquine; Membrane Transport Proteins; Middle Aged; Multidrug Resistance-Associated Proteins; Parasitic Sensitivity Tests; Plasmodium falciparum; Quinolines; Young Adult | 2015 |
How Robust Are Malaria Parasite Clearance Rates as Indicators of Drug Effectiveness and Resistance?
Topics: Adult; Antimalarials; Artemisinins; Artesunate; Child; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Combinations; Drug Dosage Calculations; Drug Resistance; Humans; Immunity, Innate; Malaria, Falciparum; Mefloquine; Models, Statistical; Parasitemia; Parasitic Sensitivity Tests; Plasmodium falciparum; Quinolines; Treatment Outcome | 2015 |
In Vitro Activities of Primaquine-Schizonticide Combinations on Asexual Blood Stages and Gametocytes of Plasmodium falciparum.
Topics: Antimalarials; Benzothiazoles; Chloroquine; Diamines; Drug Combinations; Drug Interactions; Erythrocytes; Ethanolamines; Flow Cytometry; Fluorenes; Humans; Lumefantrine; Mefloquine; Organic Chemicals; Parasitic Sensitivity Tests; Plasmodium falciparum; Primaquine; Quinolines; Sporozoites; Trophozoites | 2015 |
Expression of Plasmodium vivax crt-o Is Related to Parasite Stage but Not Ex Vivo Chloroquine Susceptibility.
Topics: Amodiaquine; Antimalarials; Artemisinins; Artesunate; Chloroquine; Drug Resistance, Multiple; Erythrocytes; Fructose-Bisphosphate Aldolase; Gene Expression Regulation; Humans; Inhibitory Concentration 50; Life Cycle Stages; Malaria, Vivax; Mefloquine; Membrane Transport Proteins; Plasmodium vivax; Protozoan Proteins; Quinolines; Transcription, Genetic; Tubulin | 2016 |
Back on TRAC: New trial launched in bid to outpace multidrug-resistant malaria.
Topics: Antimalarials; Artemisinins; Asia, Southeastern; Drug Resistance, Multiple; Drug Therapy, Combination; Humans; India; Malaria; Malaria, Falciparum; Mefloquine; Plasmodium falciparum; Quinolines | 2016 |
Absence of Association between Polymorphisms in the RING E3 Ubiquitin Protein Ligase Gene and Ex Vivo Susceptibility to Conventional Antimalarial Drugs in Plasmodium falciparum Isolates from Dakar, Senegal.
Topics: Antimalarials; Artemisinins; Artesunate; Chloroquine; Doxycycline; Ethanolamines; Fluorenes; Lumefantrine; Mefloquine; Naphthyridines; Plasmodium falciparum; Polymorphism, Genetic; Quinine; Quinolines; Senegal; Ubiquitin-Protein Ligases | 2016 |
Association between Polymorphisms in the Pf
Topics: Amodiaquine; Antimalarials; Artemisinins; Artesunate; Asparagine; ATP-Binding Cassette Transporters; Chloroquine; Doxycycline; Drug Resistance; Ethanolamines; Fluorenes; Gene Expression; Humans; Inhibitory Concentration 50; Lumefantrine; Malaria, Falciparum; Mefloquine; Naphthyridines; Plasmodium falciparum; Polymorphism, Genetic; Protein Isoforms; Protozoan Proteins; Quinine; Quinolines; Repetitive Sequences, Amino Acid; Senegal | 2017 |
Partner-Drug Resistance and Population Substructuring of Artemisinin-Resistant Plasmodium falciparum in Cambodia.
Topics: Adult; Antipruritics; Artemisinins; Cambodia; Drug Resistance; Female; Humans; Malaria, Falciparum; Male; Mefloquine; Phylogeny; Plasmodium falciparum; Protozoan Proteins; Quinolines; Treatment Failure | 2017 |
Topics: Anti-Bacterial Agents; Antimalarials; Artemether; Artemisinins; Atovaquone; Azithromycin; Chloroquine; Doxycycline; Ethanolamines; Fluorenes; Humans; India; Lumefantrine; Malaria, Falciparum; Mefloquine; Plasmodium falciparum; Quinine; Quinolines | 2017 |
Investigating the Efficacy of Triple Artemisinin-Based Combination Therapies for Treating Plasmodium falciparum Malaria Patients Using Mathematical Modeling.
Topics: Antimalarials; Artemisinins; Asia, Southeastern; Drug Therapy, Combination; Humans; Malaria, Falciparum; Mefloquine; Models, Theoretical; Plasmodium falciparum; Quinolines | 2018 |
Topics: Antimalarials; Artemisinins; Artesunate; Computer Simulation; Drug Resistance; Drug Therapy, Combination; Humans; Malaria, Falciparum; Mefloquine; Models, Biological; Plasmodium falciparum; Quinolines; Treatment Failure | 2018 |
Improving Methods for Analyzing Antimalarial Drug Efficacy Trials: Molecular Correction Based on Length-Polymorphic Markers
Topics: Algorithms; Antigens, Protozoan; Antimalarials; Artemisinins; Biomarkers; Clinical Trials as Topic; Gene Expression; Humans; Lumefantrine; Malaria, Falciparum; Mefloquine; Merozoite Surface Protein 1; Models, Statistical; Parasitic Sensitivity Tests; Plasmodium falciparum; Polymorphism, Restriction Fragment Length; Protozoan Proteins; Quinolines; Time Factors; Treatment Outcome | 2019 |
Impact of the first-line treatment shift from dihydroartemisinin/piperaquine to artesunate/mefloquine on Plasmodium vivax drug susceptibility in Cambodia.
Topics: Antimalarials; Artemisinins; Artesunate; Cambodia; DNA Copy Number Variations; Drug Resistance; Humans; Malaria, Vivax; Mefloquine; Pharmaceutical Preparations; Plasmodium falciparum; Plasmodium vivax; Protozoan Proteins; Quinolines | 2020 |
Ex-vivo Sensitivity of Plasmodium falciparum to Common Anti-malarial Drugs: The Case of Kéniéroba, a Malaria Endemic Village in Mali.
Topics: Adolescent; Amodiaquine; Antimalarials; Artemisinins; Child; Child, Preschool; Chloroquine; Drug Resistance; Endemic Diseases; Humans; Infant; Inhibitory Concentration 50; Lumefantrine; Malaria, Falciparum; Mali; Mefloquine; Plasmodium falciparum; Quinine; Quinolines | 2020 |
Distribution and Temporal Dynamics of Plasmodium falciparum Chloroquine Resistance Transporter Mutations Associated With Piperaquine Resistance in Northern Cambodia.
Topics: Animals; Antimalarials; Biomarkers; Cambodia; Drug Resistance; Malaria, Falciparum; Mefloquine; Membrane Transport Proteins; Mutation; Piperazines; Plasmodium falciparum; Prevalence; Protozoan Proteins; Quinolines; Real-Time Polymerase Chain Reaction | 2021 |
Structure-switching aptamer sensors for the specific detection of piperaquine and mefloquine.
Topics: Antimalarials; Aptamers, Nucleotide; Humans; Malaria; Mefloquine; Quinolines | 2021 |
Arterolane-based combinations for the treatment of uncomplicated falciparum malaria in Kenyan children.
Topics: Antimalarials; Child; Child, Preschool; Drug Resistance; Drug Therapy, Combination; Female; Heterocyclic Compounds, 1-Ring; Humans; Kenya; Malaria, Falciparum; Male; Mefloquine; Peroxides; Plasmodium falciparum; Quinolines; Spiro Compounds | 2021 |
Prevalence and characterization of piperaquine, mefloquine and artemisinin derivatives triple-resistant Plasmodium falciparum in Cambodia.
Topics: Antimalarials; Artemisinins; Artesunate; Cambodia; Drug Resistance; Humans; Malaria, Falciparum; Mefloquine; Plasmodium falciparum; Prevalence; Quinolines | 2023 |