Compounds > piperaquine
Page last updated: 2024-09-03

piperaquine and chloroquine

piperaquine has been researched along with chloroquine in 91 studies

Compound Research Comparison

Studies
(piperaquine)		Trials
(piperaquine)		Recent Studies (post-2010)
(piperaquine)		Studies
(chloroquine)		Trials
(chloroquine)		Recent Studies (post-2010) (chloroquine)
63822749716,4057634,029

Protein Interaction Comparison

ProteinTaxonomypiperaquine (IC50)chloroquine (IC50)
glucose-6-phosphate dehydrogenase-6-phosphogluconolactonasePlasmodium berghei43
Spike glycoproteinBetacoronavirus England 15.47
Replicase polyprotein 1abBetacoronavirus England 15.47
Transmembrane protease serine 2Homo sapiens (human)5.47
Dihydrofolate reductase Bos taurus (cattle)0.0301
Amyloid-beta precursor proteinHomo sapiens (human)7
Histidine-rich protein PFHRP-IIPlasmodium falciparum (malaria parasite P. falciparum)0.2383
Procathepsin LHomo sapiens (human)5.47
Replicase polyprotein 1aSevere acute respiratory syndrome-related coronavirus5.47
Replicase polyprotein 1abHuman coronavirus 229E5.47
Replicase polyprotein 1abSevere acute respiratory syndrome-related coronavirus5.47
Spike glycoproteinSevere acute respiratory syndrome coronavirus 23.58
Replicase polyprotein 1abSevere acute respiratory syndrome coronavirus 26.375
Ribosyldihydronicotinamide dehydrogenase [quinone]Homo sapiens (human)1.5
Serine/threonine-protein kinase mTORHomo sapiens (human)0.27
Beta-secretase 1Homo sapiens (human)7
Spike glycoproteinSevere acute respiratory syndrome-related coronavirus5.47
Potassium voltage-gated channel subfamily H member 2Homo sapiens (human)2.503
Angiotensin-converting enzyme 2 Homo sapiens (human)6.235
Cysteine proteinase falcipain 2a Plasmodium falciparum (malaria parasite P. falciparum)0.02
Cysteine proteinase falcipain 2a Plasmodium falciparum (malaria parasite P. falciparum)0.2

Research

Studies (91)

TimeframeStudies, this research(%)All Research%
pre-199010 (10.99)18.7374
1990's5 (5.49)18.2507
2000's14 (15.38)29.6817
2010's46 (50.55)24.3611
2020's16 (17.58)2.80

Authors

AuthorsStudies
Ager, AL; Andersen, SL; Ellis, WY; Gerena, L; Milhous, WK; Vennerstrom, JL1
Adagu, IS; Fivelman, QL; Warhurst, DC1
Batty, KT; Davis, TM; Ilett, KF; Karunajeewa, HA; Lammey, J; Law, I; Lin, E; Mueller, I; Page-Sharp, M; Siba, P1
Anstey, NM; Brockman, A; Chalfein, F; Cheng, Q; Kenangalem, E; Piera, K; Prasetyorini, B; Prayoga, P; Price, RN; Russell, B; Sugiarto, P; Suwanarusk, R; Tjitra, E1
Becker, K; Davioud-Charvet, E; Friebolin, W; Furrer, J; Jannack, B; Lanzer, M; Oeser, T; Sanchez, CP; Wenzel, N; Yardley, V1
Anstey, NM; Chalfien, F; Hasugian, AR; Kenangalem, E; Marfurt, J; Penttinen, PM; Piera, KA; Price, RN; Purba, HL; Ratcliff, A; Russell, B; Siswantoro, H; Tjitra, E; Wuwung, RM1
Johnson, DJ; Krudsood, S; Looareesuwan, S; Muangnoicharoen, S; Ward, SA1
Masseno, V; Muriithi, S; Nzila, A1
Abdirahman, A; Borrmann, S; Bull, P; Diriye, A; Kiara, SM; Marsh, K; Mwai, L; Nzila, A; Pole, L; Rippert, A1
Greenhouse, B; Joloba, M; Kiggundu, M; Nanyunja, S; Nsobya, SL; Rosenthal, PJ1
Jain, M; Jain, R; Kaur, K; Reddy, RP1
Borrmann, S; Kiara, SM; Mwai, L; Nzila, A; Ochola, LI; Ohuma, E; Okombo, J; Pole, L; Rono, J1
Amalvict, R; Baret, E; Briolant, S; Didillon, E; Henry, M; Oeuvray, C; Pradines, B; Rogier, C1
Anstey, NM; Chalfein, F; Kenangalem, E; Marfurt, J; Piera, KA; Price, RN; Russell, B; Tjitra, E1
Anstey, NM; Chalfein, F; Ebsworth, EP; Kenangalem, E; Marfurt, J; Piera, KA; Prasetyorini, B; Price, RN; Ratcliff, A; Russell, B; Siswantoro, H; Tjitra, E; Wuwung, M1
Andrews, KT; Anstey, NM; Chalfein, F; Fairlie, DP; Kenangalem, E; Marfurt, J; Piera, KA; Prayoga, P; Price, RN; Tjitra, E; Wabiser, F1
Biamonte, MA; Le Roch, KG; Wanner, J1
Avery, VM; Baell, JB; Ban, K; Beveridge, JG; Blundell, S; Charman, SA; Chavchich, M; Chiu, FCK; Creek, D; Cuellar, ME; Dahlin, JL; Diab, S; Dingjan, T; Duffy, S; Edstein, MD; Ellis, K; Fletcher, S; Harjani, JR; Huang, F; Lucantoni, L; Marfurt, J; Noviyanti, R; Price, RN; Ralph, SA; Shi, DH; Strasser, JM; Teguh, S; Walters, MA; Wirjanata, G; Xue, L1
Bane, CE; Black, C; Butler, K; Caridha, D; Cooper, RA; Dodean, RA; Gaona, H; Gaynor-Ohnstad, L; Huezo, SJ; Kancharla, P; Kelly, JX; Kreishman-Deitrick, M; Leed, SE; Li, Q; Li, Y; Lin, H; Luong, TL; Marcsisin, S; Melendez, V; Nolan, C; Olmeda, R; Potter, B; Pou, S; Rasmussen, SA; Read, L; Riscoe, MK; Roncal, N; Sciotti, RJ; Smilkstein, MJ; Sousa, J; Stephens, MT; Tan, JC; Vesely, B; Vuong, C; Winter, RW; Xie, L; Zeng, Q; Zhang, J; Zhang, P1
Cheong, SL; Ng, CH; Tibon, NS1
Bane, CE; Bayles, BR; Black, C; Butler, K; Caridha, D; Ceja, FG; Cooper, RA; Dodean, RA; Gaona, H; Gaynor-Ohnstad, L; Kancharla, P; Kelly, JX; Kreishman-Deitrick, M; Leed, SE; Li, Q; Li, Y; Lin, H; Luong, TL; Marcsisin, S; Melendez, V; Mu, J; Nolan, C; Olmeda, R; Potter, B; Pou, S; Pybus, B; Rasmussen, SA; Read, L; Reynolds, KA; Riscoe, MK; Roncal, N; Rosenthal, PJ; Sciotti, RJ; Smilkstein, MJ; Sousa, J; Tumwebaze, PK; Vesely, B; Vuong, C; Xie, L; Zeng, Q; Zhang, J; Zhang, P1
Cao, DQ; Dong, Y; He, H; Liu, DQ; Liu, RJ; Yang, HL; Yang, PF; Zhang, CY1
Ha, SH; Shao, BR; Zhan, CQ1
Huang, QL; Wu, Z; Zhang, KY; Zhou, JX1
Coulanges, P; Deloron, P; Le Bras, J; Ramanamirija, JA2
Biaud, JM; Coulanges, P; Deloron, P; Le Bras, J; Ramanamirija, JA1
Li, GD1
Guan, WB; Huang, WJ; Pan, WQ; Zhou, YC1
Coulanges, P; Deloron, P; Le Bras, J; Ramanamirija, JA; Verdier, P1
Coulanges, P; Deloron, P; Ramanamirija, JA; Verdíer, F1
Dai, ZR; Jiang, ZK; Li, JC; Zhu, DQ1
Dong, Y; Liu, D; Liu, R; Yang, H; Yang, P; Zhang, B; Zhang, C1
Fan, B; Huang, Z; Ma, X; Wen, Y; Yang, J; Yang, Z; Zhao, W1
Huang, K; Liao, M; Liu, D; Yang, H; Yang, P; Yang, Y; Zhang, C1
Basco, LK; Ringwald, P1
Feng, XP; Liu, DQ1
Brzostowski, JA; Kimmel, AR; Naudé, B; Wellems, TE1
Adagu, IS; Craig, JC; Fivelman, QL; Guy, RK; Madrid, PB; Warhurst, DC1
Davis, TM; Gomorrai, PS; Griffin, S; Ilett, KF; Karunajeewa, HA; Kotab, K; Lautu, D; Law, I; Lin, E; Mueller, I; Oa, O; Page-Sharp, M; Salman, S; Senn, M; Siba, P; Suano, P; Tarongka, N; Ura, A; Wong, R1
Abiodun, O; Bell, A; Brun, R; Chollet, J; Irungu, BN; Kiboi, DM; Langat, B; Nganga, JK; Nyambati, VC; Nzila, A; Rukunga, GM; Wittlin, S1
Awab, GR; Day, NP; Dondorp, AM; Imwong, M; Kaker, F; Lee, SJ; Pukrittayakamee, S; Singhasivanon, P; White, NJ; Woodrow, CJ1
Ariey, F; Beck, HP; Decosterd, LA; Duong, S; Genton, B; Hodel, EM; Mercier, T; Olliaro, P; Zanolari, B1
Ashley, EA; Lindegardh, N; Lwin, KM; Nosten, F; Phyo, AP; Price, RN; Russell, B; Singhasivanon, P; Sriprawat, K; White, NJ1
Björkman, A; Ferreira, PE; Gil, JP; Jörnhagen, L; Malmberg, M; Nosten, F; Veiga, MI1
Anstey, NM; Chalfein, F; Haynes, RK; Kenangalem, E; Marfurt, J; Möhrle, JJ; Piera, KA; Prayoga, P; Price, RN; Sebayang, B; Wabiser, F; Wirjanata, G; Wittlin, S1
Liu, H; Wang, J; Zhang, CL; Zhou, HN1
Abdur, R; Barrette, A; Bouth, DM; Duong, S; Leang, R; Menard, D; Ringwald, P1
Beeson, JG; Goodman, CD; Langer, C; McFadden, GI; Wilson, DW1
Chen, K; Cui, L; Hao, M; He, Y; Jia, D; Li, Q; Shen, L; Sun, L; Wu, J; Xu, S; Yang, Z; Yuan, L; Zhao, H1
Arzika, I; Fandeur, T; Guillebaud, J; Issaka, M; Maazou, A; Salissou, A; Specht, S; Zamanka, H1
Burkholder, B; Bustos, MD; Delacollette, C; Wongsrichanalai, C1
Amalvict, R; Benoit, N; Bertaux, L; Cren, J; Madamet, M; Parzy, D; Pascual, A; Pradines, B; Rogier, C; Taudon, N; Travers, D1
Borrmann, S; Heiss, K; Meister, M; Mueller, AK; Pfeil, J; Sepp, KJ1
Dahlstrom, S; Ferreira, PE; Franzén, O; Gil, JP; Lum, JK; Nosten, F; Osório, NS; Veiga, MI1
Bigira, V; Bloome, J; Byaruhanga, O; Conrad, MD; Cooper, RA; Dorsey, G; Greenhouse, B; Gut, J; Havlir, DV; Kakuru, A; Kamya, MR; Kapisi, J; Kozak, B; LeClair, N; Legac, J; Nakazibwe, C; Nsobya, SL; Okiring, J; Rosenthal, PJ; Tumwebaze, P; Walakira, A1
Buathong, N; Chanarat, N; Chann, S; Chaorattanakawee, S; Chuor, CM; Gosi, P; Heng, TK; Jacob, C; Kong, N; Kuntawunginn, W; Lanteri, CA; Lin, JT; Lon, C; Plowe, C; Prom, S; Saingam, P; Saunders, DL; Se, Y; Sea, D; Sriwichai, S; Sundrakes, S; Takala-Harrison, S; Tangthongchaiwiriya, K; Teja-Isavadharm, P; Tyner, SD; Yingyuen, K; Yom, Y1
Casteras, J; Dhingra, SK; Fidock, DA; Gabryszewski, SJ; Legrand, E; Moss, EL; Musset, L; Neafsey, DE; Pelleau, S; Volkman, SK; Volney, B; Wirth, DF1
Cabrera, M; Cui, L1
Auburn, S; Handayuni, I; Marfurt, J; Noviyanti, R; Pava, Z; Poespoprodjo, JR; Price, RN; To, S; Trianty, L; Wirjanata, G1
Anvikar, AR; Arora, S; Gogtay, N; Iyer, SS; Jalali, RK; Kochar, SK; Kumar, NB; Lakhani, JD; Rajadhyaksha, GC; Rao, BH; Roy, A; Saha, N; Savargaonkar, D; Sharma, P; Solanki, BB; Srivastava, B; Tripathi, SK; Valecha, N1
Anh, ND; Ca, NTN; Dolecek, C; Dong, LT; Farrar, J; Hien, TT; Hoa, NT; Khanh, TTN; Loi, MA; Nhan, HT; Nhien, NTT; Phu, NH; Son, DH; Thai, CQ; Thai, LH; Thanh, NV; Thuan, PD; Thwaites, G; Van Toi, P; White, NJ; Wolbers, M1
Amalvict, R; Benoit, N; Diatta, B; Diawara, S; Diémé, Y; Fall, B; Fall, M; Gendrot, M; Madamet, M; Nakoulima, A; Pradines, B; Wade, B; Wade, KA1
Craig, JC; Raheem, KS; Warhurst, DC1
Liu, XJ; Peng, HJ; Wei, HX; Xia, J; Zhou, LJ1
Khositnithikul, R; Mungthin, M; Sitthichot, N; Suwandittakul, N; Ward, SA; Watanatanasup, E1
Amalvict, R; Benoit, N; Briolant, S; Diatta, B; Diawara, S; Diémé, Y; Fall, B; Fall, M; Gendrot, M; Kounta, MB; Madamet, M; Nakoulima, A; Pradines, B; Wade, B; Wade, KA1
Affara, M; Bei, AK; Deme, AB; Dieye, B; Diongue, K; Gaye, A; Koita, O; Krogstad, DJ; Mbaye, A; Ndiaye, D; Ndiaye, IM; Ndiaye, T; Ndiaye, YD; Nwakanma, D; Sy, M; Sy, N; Volkman, S; Yade, MS1
Byaruhanga, O; Ceja, FG; Conrad, MD; Cooper, RA; Katairo, T; Nsobya, SL; Rasmussen, SA; Rosenthal, PJ; Tumwebaze, PK1
Agarwal, P; Anvikar, AR; Pillai, CR; Srivastava, K1
Bin, S; Kim, S; Lek, D; Menard, D; Piv, EP; Popovici, J; Primault, L; Samreth, R; Serre, D; Vantaux, A1
Ariey, F; Dhingra, SK; Fairhurst, RM; Fidock, DA; Kümpornsin, K; Menard, D; Mok, S; Ross, LS; Takala-Harrison, S; Wicht, KJ; Witkowski, B; Yeo, T1
Cen, YZ; Deng, ZH; Li, XH; Liao, YB; Lin, RX; Liu, MR; Pan, B; Pei, FQ; Ren, WF; Ruan, CW1
Asua, V; Conrad, MD; Dorsey, G; Kamya, MR; Kigozi, SP; Legac, J; Nsobya, SL; Rosenthal, PJ; Vinden, J1
Ansbro, MR; Chookajorn, T; Chotivanich, K; de Cozar, C; Gamo, FJ; Kochakarn, T; Kotanan, N; Kümpornsin, K; Lee, MCS; Loesbanluechai, D; Sanz, LM; White, NJ; Wilairat, P1
Birrell, GW; Chavchich, M; Chuang, I; Edstein, MD; Manh, ND; Martin, NJ; Phong, NC; Quang, HH; San, NN1
Bancone, G; Carrara, VI; Chu, CS; Imwong, M; Jeeyapant, A; Lee, SJ; Nosten, F; Paw, MK; Phyo, AP; Poe, NP; Proux, S; Raksapraidee, R; Sriprawat, K; Tarning, J; Thinraow, S; Turner, C; Watson, J; White, NJ; Wiladphaingern, J; Wilairisak, P; Win, HH; Yotyingaphiram, W1
Clain, J; Coppée, R; Sabbagh, A1
Fidock, DA; Hagenah, LM; Small-Saunders, JL1
Bah, S; Dabitao, D; Dama, S; Diakité, M; Diakité, SAS; Doumbia, S; Doumbouya, M; Guindo, MA; Keita, B; Konaté, DS; Sangaré, M; Sanogo, I; Traoré, K1
Riegel, B; Roepe, PD1
Conrad, MD; Cooper, RA; Duvalsaint, M; Legac, J; Rosenthal, PJ; Tukwasibwe, S; Tumwebaze, PK1
Anstey, NM; Apriyanti, D; Auburn, S; Brockman, A; Chalfein, F; Kenangalem, E; Leonardo, L; Luo, I; MacHunter, B; Marfurt, J; Noviyanti, R; Piera, KA; Poespoprodjo, JR; Prayoga, P; Price, RN; Rumaseb, A; Russell, B; Sebayang, BF; Sihombing, MAEM; Suwanarusk, R; Trianty, L; Wirjanata, G1
Deni, I; Dhingra, SK; Eppstein, MJ; Fidock, DA; Gil-Iturbe, E; Hagenah, LM; Kim, J; Mancia, F; Mehta, M; Quick, M; Roepe, PD; Small-Saunders, JL; Vendome, J; Wicht, KJ1
Ye, R; Zhang, D; Zhang, Y1
Boonyalai, N; Griesenbeck, JS; Kirativanich, K; Praditpol, C; Thamnurak, C; Vesely, BA; Waters, NC; Wojnarski, M1
Fidock, DA; Hagenah, LM; Mok, S; Small-Saunders, JL; Wicht, KJ1
Albert, I; Bath, J; Fidock, DA; Koo, I; Llinás, M; Mok, S; Okombo, J; Orchard, LM; Owens, E; Qahash, T; Yeo, T1
Abera, A; Alemayehu, BH; Anand, A; Assefa, A; Bekele, W; Dilu, D; Etana, K; Ezema, B; Girma, S; Haile, M; Hwang, J; Minta, AA; Mohammed, H; Moriarty, LF; Murphy, M; Sime, H; Solomon, H; Svigel, SS; Tadesse, M; Tadesse, Y; Tasew, G; Teka, H; Woyessa, A; Zhou, Z1
Baird, JK; Berni, A; Budiman, W; Cedar, E; Chand, K; Crenna-Darusallam, C; Duparc, S; Ekawati, LL; Elyazar, I; Fernando, D; Fletcher, K; Goyal, N; Green, JA; Instiaty, I; Jones, S; Kleim, JP; Lardo, S; Martin, A; Noviyanti, R; Prasetya, CB; Rolfe, K; Santy, YW; Satyagraha, AW; Sharma, H; Soebandrio, A; Subekti, D; Sutanto, I; Tan, LK; Taylor, M1
Berger, F; D'Arrigo, G; Gomez, GM; Lanzer, M; Sanchez, CP; Wade, RC1

Reviews

5 review(s) available for piperaquine and chloroquine

ArticleYear
Quinolines and structurally related heterocycles as antimalarials.
    European journal of medicinal chemistry, 2010, Volume: 45, Issue:8

    Topics: Animals; Antimalarials; Humans; Quinolines; Structure-Activity Relationship

2010
Recent advances in malaria drug discovery.
    Bioorganic & medicinal chemistry letters, 2013, May-15, Volume: 23, Issue:10

    Topics: Animals; Antimalarials; Drug Discovery; Humans; Liver; Liver Transplantation; Malaria; Molecular Structure

2013
Current progress in antimalarial pharmacotherapy and multi-target drug discovery.
    European journal of medicinal chemistry, 2020, Feb-15, Volume: 188

    Topics: Animals; Antimalarials; Artemisinins; Drug Discovery; Drug Resistance; Humans; Malaria; Molecular Structure; Paclitaxel; Quinolines

2020
Monitoring antimalarial drug efficacy in the Greater Mekong Subregion: an overview of in vivo results from 2008 to 2010.
    The Southeast Asian journal of tropical medicine and public health, 2013, Volume: 44 Suppl 1

    Topics: Antimalarials; Artemether; Artemisinins; Artesunate; Asia, Southeastern; Chloroquine; Directly Observed Therapy; Drug Resistance; Drug Therapy, Combination; Ethanolamines; Fluorenes; Humans; Lumefantrine; Malaria, Falciparum; Malaria, Vivax; Mefloquine; Parasitemia; Quinolines

2013
Risk of drug resistance in Plasmodium falciparum malaria therapy-a systematic review and meta-analysis.
    Parasitology research, 2017, Volume: 116, Issue:2

    Topics: Amodiaquine; Antimalarials; Artemisinins; Chloroquine; Drug Combinations; Drug Resistance; Drug Therapy, Combination; Humans; Malaria, Falciparum; Mefloquine; Plasmodium falciparum; Pyrimethamine; Quinolines; Risk; Sulfadoxine

2017

Trials

12 trial(s) available for piperaquine and chloroquine

ArticleYear
Pharmacokinetics and efficacy of piperaquine and chloroquine in Melanesian children with uncomplicated malaria.
    Antimicrobial agents and chemotherapy, 2008, Volume: 52, Issue:1

    Topics: Animals; Antimalarials; Artemisinins; Child; Child, Preschool; Chloroquine; Drug Combinations; Drug Therapy, Combination; Female; Humans; Malaria, Falciparum; Malaria, Vivax; Male; Papua New Guinea; Plasmodium falciparum; Plasmodium vivax; Pyrimethamine; Quinolines; Sesquiterpenes; Sulfadoxine; Treatment Outcome

2008
In vitro sensitivities of Plasmodium falciparum to different antimalarial drugs in Uganda.
    Antimicrobial agents and chemotherapy, 2010, Volume: 54, Issue:3

    Topics: Antimalarials; Child; Child, Preschool; Cohort Studies; Drug Resistance; Humans; Malaria, Falciparum; Membrane Transport Proteins; Multidrug Resistance-Associated Proteins; Parasitic Sensitivity Tests; Plasmodium falciparum; Polymorphism, Genetic; Protozoan Proteins; Treatment Outcome; Uganda

2010
A trial of combination antimalarial therapies in children from Papua New Guinea.
    The New England journal of medicine, 2008, Dec-11, Volume: 359, Issue:24

    Topics: Antimalarials; Artemether; Artemisinins; Artesunate; Child, Preschool; Chloroquine; Drug Therapy, Combination; Ethanolamines; Female; Fluorenes; Humans; Infant; Kaplan-Meier Estimate; Lumefantrine; Malaria, Falciparum; Malaria, Vivax; Male; Proportional Hazards Models; Pyrimethamine; Quinolines; Recurrence; Sulfadoxine

2008
Dihydroartemisinin-piperaquine versus chloroquine to treat vivax malaria in Afghanistan: an open randomized, non-inferiority, trial.
    Malaria journal, 2010, Apr-21, Volume: 9

    Topics: Adolescent; Afghanistan; Antimalarials; Artemisinins; Child; Child, Preschool; Chloroquine; Drug Administration Schedule; Drug Therapy, Combination; Female; Follow-Up Studies; Humans; Infant; Malaria, Vivax; Male; Multivariate Analysis; Plasmodium vivax; Prospective Studies; Quinolines; Recurrence; Treatment Outcome

2010
Dihydroartemisinin-piperaquine versus chloroquine in the treatment of Plasmodium vivax malaria in Thailand: a randomized controlled trial.
    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2011, Volume: 53, Issue:10

    Topics: Adolescent; Adult; Antimalarials; Artemisinins; Child; Child, Preschool; Chloroquine; Female; Humans; Infant; Malaria, Vivax; Male; Middle Aged; Parasitic Sensitivity Tests; Plasmodium vivax; Quinolines; Recurrence; Risk Factors; Treatment Outcome; Young Adult

2011
Comparison of the safety and efficacy of fixed-dose combination of arterolane maleate and piperaquine phosphate with chloroquine in acute, uncomplicated Plasmodium vivax malaria: a phase III, multicentric, open-label study.
    Malaria journal, 2016, Jan-27, Volume: 15

    Topics: Adolescent; Adult; Aged; Antimalarials; Chloroquine; Drug Therapy, Combination; Female; Heterocyclic Compounds, 1-Ring; Humans; Malaria; Malaria, Vivax; Male; Maleates; Middle Aged; Peroxides; Quinolines; Spiro Compounds; Young Adult

2016
A Randomized Comparison of Chloroquine Versus Dihydroartemisinin-Piperaquine for the Treatment of Plasmodium vivax Infection in Vietnam.
    The American journal of tropical medicine and hygiene, 2016, Volume: 94, Issue:4

    Topics: Antimalarials; Artemisinins; Chloroquine; Drug Therapy, Combination; Female; Humans; Malaria, Vivax; Male; Plasmodium vivax; Quinolines; Treatment Outcome; Vietnam; Young Adult

2016
Changing Antimalarial Drug Sensitivities in Uganda.
    Antimicrobial agents and chemotherapy, 2017, Volume: 61, Issue:12

    Topics: Adolescent; Amodiaquine; Antimalarials; Artemisinins; Aspartic Acid Endopeptidases; Child; Child, Preschool; Chloroquine; Drug Resistance; Ethanolamines; Female; Fluorenes; Gene Expression; Humans; Infant; Inhibitory Concentration 50; Lumefantrine; Malaria, Falciparum; Male; Mefloquine; Membrane Transport Proteins; Multidrug Resistance-Associated Proteins; Mutation; Parasitic Sensitivity Tests; Plasmodium falciparum; Protozoan Proteins; Quinolines; Uganda; Young Adult

2017
Therapeutic and Transmission-Blocking 
Efficacy of Dihydroartemisinin/Piperaquine and Chloroquine against Plasmodium vivax Malaria, Cambodia.
    Emerging infectious diseases, 2018, Volume: 24, Issue:8

    Topics: Adolescent; Adult; Antimalarials; Artemisinins; Chloroquine; Drug Combinations; Female; Humans; Malaria, Vivax; Male; Middle Aged; Plasmodium vivax; Quinolines; Young Adult

2018
Chloroquine Versus Dihydroartemisinin-Piperaquine With Standard High-dose Primaquine Given Either for 7 Days or 14 Days in Plasmodium vivax Malaria.
    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2019, 04-08, Volume: 68, Issue:8

    Topics: Adolescent; Adult; Antimalarials; Artemisinins; Child; Child, Preschool; Chloroquine; Drug Administration Schedule; Drug Therapy, Combination; Female; Humans; Infant; Malaria, Vivax; Male; Middle Aged; Myanmar; Primaquine; Quinolines; Recurrence; Thailand; Young Adult

2019
Therapeutic efficacies of artemether-lumefantrine and dihydroartemisinin-piperaquine for the treatment of uncomplicated Plasmodium falciparum and chloroquine and dihydroartemisinin-piperaquine for uncomplicated Plasmodium vivax infection in Ethiopia.
    Malaria journal, 2022, Dec-01, Volume: 21, Issue:1

    Topics: Antimalarials; Artemether; Artemether, Lumefantrine Drug Combination; Artemisinins; Chloroquine; Ethiopia; Humans; Malaria, Falciparum; Malaria, Vivax; Plasmodium falciparum; Plasmodium vivax

2022
Tafenoquine co-administered with dihydroartemisinin-piperaquine for the radical cure of Plasmodium vivax malaria (INSPECTOR): a randomised, placebo-controlled, efficacy and safety study.
    The Lancet. Infectious diseases, 2023, Volume: 23, Issue:10

    Topics: Antimalarials; Artemisinins; Chloroquine; Drug Therapy, Combination; Humans; Malaria; Malaria, Vivax; Plasmodium vivax; Primaquine; Quinolines

2023

Other Studies

74 other study(ies) available for piperaquine and chloroquine

ArticleYear
Bisquinolines. 1. N,N-bis(7-chloroquinolin-4-yl)alkanediamines with potential against chloroquine-resistant malaria.
    Journal of medicinal chemistry, 1992, May-29, Volume: 35, Issue:11

    Topics: Animals; Antimalarials; Chloroquine; Cyclohexylamines; Drug Resistance; Malaria; Molecular Conformation; Molecular Structure; Plasmodium berghei; Plasmodium falciparum; Quinolines; Structure-Activity Relationship

1992
Effects of piperaquine, chloroquine, and amodiaquine on drug uptake and of these in combination with dihydroartemisinin against drug-sensitive and -resistant Plasmodium falciparum strains.
    Antimicrobial agents and chemotherapy, 2007, Volume: 51, Issue:6

    Topics: Amodiaquine; Animals; Antimalarials; Artemisinins; Chloroquine; Drug Antagonism; Drug Combinations; Drug Interactions; Drug Resistance; Parasitic Sensitivity Tests; Plasmodium falciparum; Quinolines; Sesquiterpenes; Tritium

2007
Determinants of in vitro drug susceptibility testing of Plasmodium vivax.
    Antimicrobial agents and chemotherapy, 2008, Volume: 52, Issue:3

    Topics: Animals; Antimalarials; Chloroquine; Humans; Inhibitory Concentration 50; Life Cycle Stages; Parasitic Sensitivity Tests; Plasmodium falciparum; Plasmodium vivax; Schizonts; Time Factors

2008
Antimalarial dual drugs based on potent inhibitors of glutathione reductase from Plasmodium falciparum.
    Journal of medicinal chemistry, 2008, Mar-13, Volume: 51, Issue:5

    Topics: Animals; Antimalarials; Biological Transport; Cell Line, Tumor; Chloroquine; Drug Resistance; Drug Therapy, Combination; Glutathione Reductase; Humans; In Vitro Techniques; Malaria; Mice; Mice, Inbred BALB C; Naphthalenes; Parasitic Sensitivity Tests; Plasmodium berghei; Plasmodium falciparum; Structure-Activity Relationship

2008
In vivo and in vitro efficacy of amodiaquine monotherapy for treatment of infection by chloroquine-resistant Plasmodium vivax.
    Antimicrobial agents and chemotherapy, 2009, Volume: 53, Issue:3

    Topics: Adolescent; Age Distribution; Amodiaquine; Animals; Antimalarials; Chloroquine; Confidence Intervals; Drug Resistance; Drug Tolerance; Female; Follow-Up Studies; Humans; Inhibitory Concentration 50; Male; Outpatients; Parasitemia; Plasmodium vivax; Prospective Studies; Recurrence; Rural Health; Time Factors; Treatment Failure; Treatment Outcome

2009
Role of known molecular markers of resistance in the antimalarial potency of piperaquine and dihydroartemisinin in vitro.
    Antimicrobial agents and chemotherapy, 2009, Volume: 53, Issue:4

    Topics: Animals; Antimalarials; Artemisinins; Chloroquine; Drug Resistance; Drug Therapy, Combination; Membrane Transport Proteins; Multidrug Resistance-Associated Proteins; Plasmodium falciparum; Protozoan Proteins; Quinolines

2009
In vitro chemosensitization of Plasmodium falciparum to antimalarials by verapamil and probenecid.
    Antimicrobial agents and chemotherapy, 2009, Volume: 53, Issue:7

    Topics: Adjuvants, Pharmaceutic; Animals; Antimalarials; Parasitic Sensitivity Tests; Plasmodium falciparum; Probenecid; Verapamil

2009
In vitro activities of piperaquine, lumefantrine, and dihydroartemisinin in Kenyan Plasmodium falciparum isolates and polymorphisms in pfcrt and pfmdr1.
    Antimicrobial agents and chemotherapy, 2009, Volume: 53, Issue:12

    Topics: Animals; Antimalarials; Artemisinins; Ethanolamines; Fluorenes; Genotype; Humans; Lumefantrine; Malaria, Falciparum; Membrane Transport Proteins; Microbial Sensitivity Tests; Multidrug Resistance-Associated Proteins; Plasmodium falciparum; Polymorphism, Genetic; Protozoan Proteins; Quinolines

2009
In vitro activities of quinine and other antimalarials and pfnhe polymorphisms in Plasmodium isolates from Kenya.
    Antimicrobial agents and chemotherapy, 2010, Volume: 54, Issue:8

    Topics: Amino Acid Sequence; Animals; Antimalarials; Drug Resistance; Humans; Kenya; Mefloquine; Membrane Transport Proteins; Molecular Sequence Data; Multidrug Resistance-Associated Proteins; Parasitic Sensitivity Tests; Phenanthrenes; Plasmodium falciparum; Polymorphism, Genetic; Protozoan Proteins; Quinine; Sequence Analysis, DNA; Sodium-Hydrogen Exchangers

2010
Absence of association between piperaquine in vitro responses and polymorphisms in the pfcrt, pfmdr1, pfmrp, and pfnhe genes in Plasmodium falciparum.
    Antimicrobial agents and chemotherapy, 2010, Volume: 54, Issue:9

    Topics: Animals; Antimalarials; Membrane Transport Proteins; Multidrug Resistance-Associated Proteins; Plasmodium falciparum; Polymorphism, Genetic; Polymorphism, Single Nucleotide; Protozoan Proteins; Quinolines

2010
In vitro activity of pyronaridine against multidrug-resistant Plasmodium falciparum and Plasmodium vivax.
    Antimicrobial agents and chemotherapy, 2010, Volume: 54, Issue:12

    Topics: Animals; Antimalarials; Chloroquine; Drug Resistance, Multiple; Inhibitory Concentration 50; Naphthyridines; Plasmodium falciparum; Plasmodium vivax

2010
In vivo and in vitro efficacy of chloroquine against Plasmodium malariae and P. ovale in Papua, Indonesia.
    Antimicrobial agents and chemotherapy, 2011, Volume: 55, Issue:1

    Topics: Adolescent; Adult; Antimalarials; Child; Child, Preschool; Chloroquine; Female; Humans; Indonesia; Malaria; Male; Middle Aged; Plasmodium malariae; Plasmodium ovale; Treatment Outcome; Young Adult

2011
Ex vivo activity of histone deacetylase inhibitors against multidrug-resistant clinical isolates of Plasmodium falciparum and P. vivax.
    Antimicrobial agents and chemotherapy, 2011, Volume: 55, Issue:3

    Topics: Drug Resistance, Multiple, Bacterial; Histone Deacetylase Inhibitors; Hydroxamic Acids; Microbial Sensitivity Tests; Plasmodium falciparum; Plasmodium vivax; Vorinostat

2011
3,3'-Disubstituted 5,5'-Bi(1,2,4-triazine) Derivatives with Potent in Vitro and in Vivo Antimalarial Activity.
    Journal of medicinal chemistry, 2019, 03-14, Volume: 62, Issue:5

    Topics: Animals; Antimalarials; Chloroquine; Drug Resistance; Humans; In Vitro Techniques; Magnetic Resonance Spectroscopy; Mice; Molecular Structure; Plasmodium; Species Specificity; Structure-Activity Relationship; Triazines

2019
Discovery and Structural Optimization of Acridones as Broad-Spectrum Antimalarials.
    Journal of medicinal chemistry, 2019, 04-11, Volume: 62, Issue:7

    Topics: Acridones; Animals; Antimalarials; Disease Models, Animal; Drug Discovery; Hep G2 Cells; Humans; Malaria; Mice; Plasmodium; Species Specificity; Structure-Activity Relationship

2019
Lead Optimization of Second-Generation Acridones as Broad-Spectrum Antimalarials.
    Journal of medicinal chemistry, 2020, 06-11, Volume: 63, Issue:11

    Topics: Acridones; Administration, Oral; Animals; Antimalarials; Cell Survival; Disease Models, Animal; Female; Half-Life; Hep G2 Cells; Humans; Life Cycle Stages; Malaria; Male; Mice; Mice, Inbred C57BL; Plasmodium falciparum; Structure-Activity Relationship

2020
[Sensitivity in vitro of Plasmodium falciparum to chloroquine, pyronaridine, artesunate and piperaquine in south Yunnan].
    Zhongguo ji sheng chong xue yu ji sheng chong bing za zhi = Chinese journal of parasitology & parasitic diseases, 1992, Volume: 10, Issue:3

    Topics: Animals; Antimalarials; Artemisinins; Artesunate; Chloroquine; Drug Resistance; Naphthyridines; Plasmodium falciparum; Quinolines; Sesquiterpenes

1992
[Evaluation of the phototoxicity of five antimalarial agents and praziquantel in mice].
    Zhongguo yao li xue bao = Acta pharmacologica Sinica, 1986, Volume: 7, Issue:3

    Topics: Animals; Antimalarials; Chloroquine; Female; Male; Mice; Naphthyridines; Photosensitivity Disorders; Praziquantel; Quinacrine; Quinazolines; Quinolines; Ultraviolet Rays

1986
[Susceptibility of Plasmodium falciparum to chloroquine, piperaquine, amodiaquine, mefloquine and quinine with in vitro microtechnique in Hainan Island].
    Zhongguo ji sheng chong xue yu ji sheng chong bing za zhi = Chinese journal of parasitology & parasitic diseases, 1987, Volume: 5, Issue:3

    Topics: Amodiaquine; Animals; Antimalarials; Chloroquine; Drug Resistance; Drug Synergism; Mefloquine; Plasmodium falciparum; Quinolines

1987
Plasmodium falciparum in Madagascar: in vivo and in vitro sensitivity to seven drugs.
    Annals of tropical medicine and parasitology, 1985, Volume: 79, Issue:4

    Topics: Adolescent; Adult; Aged; Amodiaquine; Antimalarials; Child; Child, Preschool; Chloroquine; Humans; Infant; Madagascar; Malaria; Mefloquine; Microbial Sensitivity Tests; Middle Aged; Phenanthrenes; Piperazines; Plasmodium falciparum; Quinine; Quinolines

1985
[In vivo and in vitro sensitivity to 4-aminoquinolines of Plasmodium falciparum in Madagascar: results of 2 years' study].
    Bulletin de la Societe de pathologie exotique et de ses filiales, 1985, Volume: 78, Issue:5

    Topics: Aminoquinolines; Amodiaquine; Animals; Antimalarials; Chloroquine; Drug Resistance, Microbial; Humans; In Vitro Techniques; Madagascar; Malaria; Phenanthrenes; Piperazines; Plasmodium falciparum; Quinine; Quinolines

1985
[Development of a piperaquine-resistant line of Plasmodium berghei K 173 strain].
    Yao xue xue bao = Acta pharmaceutica Sinica, 1985, Volume: 20, Issue:6

    Topics: Animals; Antimalarials; Artemisinins; Artesunate; Chloroquine; Drug Resistance; Malaria; Male; Mefloquine; Mice; Plasmodium berghei; Quinolines; Sesquiterpenes

1985
[Effect of piperaquine and hydroxypiperaquine on a chloroquine-resistant strain of Plasmodium falciparum].
    Ji sheng chong xue yu ji sheng chong bing za zhi = Journal of parasitology & parasitic diseases, 1983, Volume: 1, Issue:2

    Topics: Animals; Antimalarials; Chloroquine; Drug Resistance, Microbial; Plasmodium falciparum; Quinolines

1983
[4-Aminoquinoline-sensitivity of Plasmodium falciparum in Madagascar. I. Study in two regions of the west coast].
    Archives de l'Institut Pasteur de Madagascar, 1984, Volume: 51, Issue:1

    Topics: Adolescent; Aged; Aminoquinolines; Amodiaquine; Animals; Antimalarials; Child; Chloroquine; Drug Resistance, Microbial; Humans; Madagascar; Malaria; Piperazines; Plasmodium falciparum; Quinolines

1984
[4-Aminoquinoline-sensitivity of Plasmodium falciparum in Madagascar. II. Study in two regions of the east coast].
    Archives de l'Institut Pasteur de Madagascar, 1984, Volume: 51, Issue:1

    Topics: Aminoquinolines; Amodiaquine; Antimalarials; Child; Chloroquine; Drug Resistance, Microbial; Humans; Madagascar; Malaria; Piperazines; Plasmodium falciparum; Quinolines

1984
[4-Aminoquinoline-sensitivity of Plasmodium falciparum in Madagascar. III. Studies in three regions of the interior].
    Archives de l'Institut Pasteur de Madagascar, 1984, Volume: 51, Issue:1

    Topics: Aminoquinolines; Amodiaquine; Antimalarials; Chloroquine; Drug Resistance, Microbial; Humans; Madagascar; Malaria; Piperazines; Plasmodium falciparum; Quinolines

1984
[Studies on piperaquine as long-acting antimalarial drug against Plasmodium berghei in mice].
    Yao xue xue bao = Acta pharmaceutica Sinica, 1982, Volume: 17, Issue:12

    Topics: Animals; Antimalarials; Chloroquine; Delayed-Action Preparations; Female; Malaria; Mice; Plasmodium berghei; Quinolines

1982
[Sensitivity of Plasmodium falciparum to seven antimalarials in China-Laos border].
    Zhongguo ji sheng chong xue yu ji sheng chong bing za zhi = Chinese journal of parasitology & parasitic diseases, 1995, Volume: 13, Issue:2

    Topics: Animals; Antimalarials; Artemisinins; Artesunate; Chloroquine; Drug Resistance; Humans; Naphthyridines; Plasmodium falciparum; Quinolines; Sesquiterpenes

1995
[In vitro sensitivity of Plasmodium falciparum to chloroquine, piperaquine, pyronaridine and artesunate in Yuxi prefecture of Yunnan province].
    Zhongguo ji sheng chong xue yu ji sheng chong bing za zhi = Chinese journal of parasitology & parasitic diseases, 1998, Volume: 16, Issue:6

    Topics: Adolescent; Adult; Animals; Antimalarials; Artemisinins; Artesunate; Child; Child, Preschool; Chloroquine; Drug Resistance; Female; Humans; In Vitro Techniques; Infant; Inhibitory Concentration 50; Malaria, Falciparum; Male; Middle Aged; Naphthyridines; Plasmodium falciparum; Quinolines; Sesquiterpenes

1998
[Assay of sensitivity of Plasmodium falciparum to chloroquine, amodiaquine, piperaquine, mefloquine and quinine in Yunnan province].
    Zhongguo ji sheng chong xue yu ji sheng chong bing za zhi = Chinese journal of parasitology & parasitic diseases, 1999, Volume: 17, Issue:1

    Topics: Amodiaquine; Animals; Antimalarials; Chloroquine; Drug Resistance; Mefloquine; Plasmodium falciparum; Quinine; Quinolines

1999
In vitro activities of piperaquine and other 4-aminoquinolines against clinical isolates of Plasmodium falciparum in Cameroon.
    Antimicrobial agents and chemotherapy, 2003, Volume: 47, Issue:4

    Topics: Aminoquinolines; Animals; Antimalarials; Cameroon; Chloroquine; Drug Resistance; Humans; Plasmodium falciparum; Quinolines

2003
[Factors affecting the in vitro microtest for drug sensitivity of Plasmodium falciparum].
    Zhongguo ji sheng chong xue yu ji sheng chong bing za zhi = Chinese journal of parasitology & parasitic diseases, 2003, Volume: 21, Issue:4

    Topics: Animals; Antimalarials; Artemisinins; Artesunate; Blood; Chloroquine; Humans; Malaria, Falciparum; Naphthyridines; Parasitic Sensitivity Tests; Plasmodium falciparum; Quinolines; Sesquiterpenes

2003
Dictyostelium discoideum expresses a malaria chloroquine resistance mechanism upon transfection with mutant, but not wild-type, Plasmodium falciparum transporter PfCRT.
    The Journal of biological chemistry, 2005, Jul-08, Volume: 280, Issue:27

    Topics: Acids; Amino Acid Sequence; Animals; Antimalarials; Chloroquine; Cytoplasmic Vesicles; Dictyostelium; Drug Resistance, Bacterial; Gene Expression; Membrane Proteins; Membrane Transport Proteins; Molecular Sequence Data; Phenotype; Phylogeny; Plasmodium falciparum; Point Mutation; Protozoan Proteins; Quinidine; Quinine; Quinolines; Transfection

2005
Activity of piperaquine and other 4-aminoquinoline antiplasmodial drugs against chloroquine-sensitive and resistant blood-stages of Plasmodium falciparum. Role of beta-haematin inhibition and drug concentration in vacuolar water- and lipid-phases.
    Biochemical pharmacology, 2007, Jun-15, Volume: 73, Issue:12

    Topics: Aminoquinolines; Animals; Antimalarials; Chloroquine; Dose-Response Relationship, Drug; Drug Resistance; Hemeproteins; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Inhibitory Concentration 50; Life Cycle Stages; Lipids; Models, Molecular; Molecular Structure; Plasmodium falciparum; Quinolines; Vacuoles; Water

2007
Plasmodium berghei ANKA: selection of resistance to piperaquine and lumefantrine in a mouse model.
    Experimental parasitology, 2009, Volume: 122, Issue:3

    Topics: Amodiaquine; Animals; Antimalarials; Artemisinins; Chloroquine; Disease Models, Animal; Drug Resistance; Ethanolamines; Female; Fluorenes; Lumefantrine; Malaria; Male; Mice; Parasitemia; Plasmodium berghei; Quinolines; Serial Passage

2009
Residual antimalarial concentrations before treatment in patients with malaria from Cambodia: indication of drug pressure.
    The Journal of infectious diseases, 2010, Oct-01, Volume: 202, Issue:7

    Topics: Adolescent; Adult; Antimalarials; Cambodia; Child; Child, Preschool; Chloroquine; Chromatography, Liquid; Drug Resistance; Female; Humans; Malaria, Falciparum; Male; Mefloquine; Middle Aged; Quinine; Quinolines; Selection, Genetic; Serum; Tandem Mass Spectrometry; Young Adult

2010
pfmdr1 amplification is related to increased Plasmodium falciparum in vitro sensitivity to the bisquinoline piperaquine.
    Antimicrobial agents and chemotherapy, 2012, Volume: 56, Issue:7

    Topics: Antimalarials; ATP-Binding Cassette Transporters; Chloroquine; Gene Dosage; Plasmodium falciparum; Protozoan Proteins; Quinolines

2012
Comparative ex vivo activity of novel endoperoxides in multidrug-resistant plasmodium falciparum and P. vivax.
    Antimicrobial agents and chemotherapy, 2012, Volume: 56, Issue:10

    Topics: Adamantane; Amodiaquine; Antimalarials; Artemisinins; Artesunate; Chloroquine; Drug Resistance, Multiple; Heterocyclic Compounds, 1-Ring; Microbial Sensitivity Tests; Peroxides; Plasmodium falciparum; Plasmodium vivax; Quinolines; Spiro Compounds

2012
[In vitro sensitivity of Plasmodium falciparum isolates from China-Myanmar border region to chloroquine, piperaquine and pyronaridine].
    Zhongguo ji sheng chong xue yu ji sheng chong bing za zhi = Chinese journal of parasitology & parasitic diseases, 2012, Feb-29, Volume: 30, Issue:1

    Topics: Adolescent; Adult; Antimalarials; Child; Child, Preschool; China; Chloroquine; Drug Resistance; Female; Humans; Malaria, Falciparum; Male; Middle Aged; Myanmar; Naphthyridines; Plasmodium falciparum; Quinolines; Young Adult

2012
Efficacy of dihydroartemisinin-piperaquine for treatment of uncomplicated Plasmodium falciparum and Plasmodium vivax in Cambodia, 2008 to 2010.
    Antimicrobial agents and chemotherapy, 2013, Volume: 57, Issue:2

    Topics: Adolescent; Adult; Antimalarials; Artemisinins; Cambodia; Child; Chloroquine; Drug Resistance; Drug Therapy, Combination; Female; Genotype; Humans; Malaria, Falciparum; Malaria, Vivax; Male; Mefloquine; Membrane Transport Proteins; Middle Aged; Parasitic Sensitivity Tests; Plasmodium falciparum; Plasmodium vivax; Protozoan Proteins; Quinolines; Treatment Outcome; Young Adult

2013
Defining the timing of action of antimalarial drugs against Plasmodium falciparum.
    Antimicrobial agents and chemotherapy, 2013, Volume: 57, Issue:3

    Topics: Amodiaquine; Antimalarials; Artemisinins; Artesunate; Chloroquine; Erythrocytes; Flow Cytometry; High-Throughput Screening Assays; Hydroxamic Acids; Inhibitory Concentration 50; Mefloquine; Merozoites; Plasmodium falciparum; Quinine; Quinolines; Schizonts; Time Factors

2013
In vitro sensitivities of Plasmodium falciparum isolates from the China-Myanmar border to piperaquine and association with polymorphisms in candidate genes.
    Antimicrobial agents and chemotherapy, 2013, Volume: 57, Issue:4

    Topics: Antimalarials; Chloroquine; Drug Resistance; Humans; Inhibitory Concentration 50; Mutation; Plasmodium falciparum; Polymorphism, Genetic; Protozoan Proteins; Quinolines

2013
Ex vivo responses of Plasmodium falciparum clinical isolates to conventional and new antimalarial drugs in Niger.
    Antimicrobial agents and chemotherapy, 2013, Volume: 57, Issue:7

    Topics: Amodiaquine; Antimalarials; Artemisinins; Chloroquine; Drug Resistance; Ethanolamines; Fluorenes; Humans; Lumefantrine; Malaria, Falciparum; Naphthyridines; Niger; Parasitic Sensitivity Tests; Plasmodium falciparum; Quinolines

2013
In vitro piperaquine susceptibility is not associated with the Plasmodium falciparum chloroquine resistance transporter gene.
    Malaria journal, 2013, Nov-25, Volume: 12

    Topics: Antimalarials; Chloroquine; Drug Resistance; France; Humans; Inhibitory Concentration 50; Membrane Transport Proteins; Models, Statistical; Plasmodium falciparum; Protozoan Proteins; Quinolines

2013
Protection against malaria by immunization with non-attenuated sporozoites under single-dose piperaquine-tetraphosphate chemoprophylaxis.
    Vaccine, 2014, Oct-14, Volume: 32, Issue:45

    Topics: Animals; CD8-Positive T-Lymphocytes; Chemoprevention; Chloroquine; Disease Models, Animal; Female; Immunologic Memory; Liver; Malaria; Malaria Vaccines; Mice, Inbred C57BL; Plasmodium berghei; Quinolines; Spleen; Sporozoites

2014
Complex polymorphisms in the Plasmodium falciparum multidrug resistance protein 2 gene and its contribution to antimalarial response.
    Antimicrobial agents and chemotherapy, 2014, Volume: 58, Issue:12

    Topics: Amino Acid Sequence; Antimalarials; Artemisinins; Biological Transport; Chloroquine; Chromosomes; Drug Resistance, Multiple; Erythrocytes; Humans; INDEL Mutation; Malaria, Falciparum; Mefloquine; Molecular Sequence Data; Multidrug Resistance-Associated Proteins; Parasitic Sensitivity Tests; Plasmodium falciparum; Polymorphism, Single Nucleotide; Quinolines; Thailand

2014
Impact of antimalarial treatment and chemoprevention on the drug sensitivity of malaria parasites isolated from ugandan children.
    Antimicrobial agents and chemotherapy, 2015, Volume: 59, Issue:6

    Topics: Amodiaquine; Antimalarials; Artemisinins; Child, Preschool; Chloroquine; Clinical Trials as Topic; Ethanolamines; Fluorenes; Humans; Infant; Lumefantrine; Membrane Transport Proteins; Multidrug Resistance-Associated Proteins; Parasitic Sensitivity Tests; Plasmodium falciparum; Polymorphism, Genetic; Protozoan Proteins; Quinine; Quinolines; Uganda

2015
Ex Vivo Drug Susceptibility Testing and Molecular Profiling of Clinical Plasmodium falciparum Isolates from Cambodia from 2008 to 2013 Suggest Emerging Piperaquine Resistance.
    Antimicrobial agents and chemotherapy, 2015, Volume: 59, Issue:8

    Topics: Adolescent; Adult; Aged; Antimalarials; Artemisinins; Cambodia; Chloroquine; Drug Resistance; Female; Humans; Inhibitory Concentration 50; Malaria, Falciparum; Male; Mefloquine; Membrane Transport Proteins; Middle Aged; Multidrug Resistance-Associated Proteins; Parasitic Sensitivity Tests; Plasmodium falciparum; Quinolines; Young Adult

2015
Adaptive evolution of malaria parasites in French Guiana: Reversal of chloroquine resistance by acquisition of a mutation in pfcrt.
    Proceedings of the National Academy of Sciences of the United States of America, 2015, Sep-15, Volume: 112, Issue:37

    Topics: Alleles; Chloroquine; Drug Resistance; Evolution, Molecular; French Guiana; Genetic Markers; Genome; Genotype; Haplotypes; Humans; Inhibitory Concentration 50; Malaria; Membrane Transport Proteins; Mutation; Phenotype; Plasmodium falciparum; Prevalence; Principal Component Analysis; Protozoan Proteins; Quinolines; Retrospective Studies

2015
In Vitro Activities of Primaquine-Schizonticide Combinations on Asexual Blood Stages and Gametocytes of Plasmodium falciparum.
    Antimicrobial agents and chemotherapy, 2015, Volume: 59, Issue:12

    Topics: Antimalarials; Benzothiazoles; Chloroquine; Diamines; Drug Combinations; Drug Interactions; Erythrocytes; Ethanolamines; Flow Cytometry; Fluorenes; Humans; Lumefantrine; Mefloquine; Organic Chemicals; Parasitic Sensitivity Tests; Plasmodium falciparum; Primaquine; Quinolines; Sporozoites; Trophozoites

2015
Expression of Plasmodium vivax crt-o Is Related to Parasite Stage but Not Ex Vivo Chloroquine Susceptibility.
    Antimicrobial agents and chemotherapy, 2016, Volume: 60, Issue:1

    Topics: Amodiaquine; Antimalarials; Artemisinins; Artesunate; Chloroquine; Drug Resistance, Multiple; Erythrocytes; Fructose-Bisphosphate Aldolase; Gene Expression Regulation; Humans; Inhibitory Concentration 50; Life Cycle Stages; Malaria, Vivax; Mefloquine; Membrane Transport Proteins; Plasmodium vivax; Protozoan Proteins; Quinolines; Transcription, Genetic; Tubulin

2016
Absence of Association between Polymorphisms in the RING E3 Ubiquitin Protein Ligase Gene and Ex Vivo Susceptibility to Conventional Antimalarial Drugs in Plasmodium falciparum Isolates from Dakar, Senegal.
    Antimicrobial agents and chemotherapy, 2016, Volume: 60, Issue:8

    Topics: Antimalarials; Artemisinins; Artesunate; Chloroquine; Doxycycline; Ethanolamines; Fluorenes; Lumefantrine; Mefloquine; Naphthyridines; Plasmodium falciparum; Polymorphism, Genetic; Quinine; Quinolines; Senegal; Ubiquitin-Protein Ligases

2016
Influence of LAR and VAR on Para-Aminopyridine Antimalarials Targetting Haematin in Chloroquine-Resistance.
    PloS one, 2016, Volume: 11, Issue:8

    Topics: Amodiaquine; Antimalarials; Biological Transport; Chloroquine; Drug Design; Drug Resistance; Heme; Hemin; Hydrophobic and Hydrophilic Interactions; Plasmodium falciparum; Quinolines; Structure-Activity Relationship; Vacuoles

2016
Influence of the
    The American journal of tropical medicine and hygiene, 2017, Volume: 96, Issue:3

    Topics: Alleles; Antimalarials; Artemisinins; Chloroquine; Drug Resistance; Gene Dosage; Genotyping Techniques; Inhibitory Concentration 50; Membrane Transport Proteins; Multidrug Resistance-Associated Proteins; Plasmodium falciparum; Polymorphism, Single Nucleotide; Protozoan Proteins; Quinolines; Thailand

2017
Association between Polymorphisms in the Pf
    Antimicrobial agents and chemotherapy, 2017, Volume: 61, Issue:3

    Topics: Amodiaquine; Antimalarials; Artemisinins; Artesunate; Asparagine; ATP-Binding Cassette Transporters; Chloroquine; Doxycycline; Drug Resistance; Ethanolamines; Fluorenes; Gene Expression; Humans; Inhibitory Concentration 50; Lumefantrine; Malaria, Falciparum; Mefloquine; Naphthyridines; Plasmodium falciparum; Polymorphism, Genetic; Protein Isoforms; Protozoan Proteins; Quinine; Quinolines; Repetitive Sequences, Amino Acid; Senegal

2017
Ex vivo susceptibility and genotyping of Plasmodium falciparum isolates from Pikine, Senegal.
    Malaria journal, 2017, 06-14, Volume: 16, Issue:1

    Topics: Adolescent; Amodiaquine; Antimalarials; Artemisinins; Child; Child, Preschool; Chloroquine; DNA, Protozoan; Drug Resistance; Fluorescent Dyes; Genotype; Genotyping Techniques; Humans; Indoles; Inhibitory Concentration 50; Malaria; Mutation; Parasitic Sensitivity Tests; Plasmodium falciparum; Polymorphism, Single Nucleotide; Pyrimethamine; Quinolines; Senegal; Young Adult

2017
    The Indian journal of medical research, 2017, Volume: 146, Issue:5

    Topics: Anti-Bacterial Agents; Antimalarials; Artemether; Artemisinins; Atovaquone; Azithromycin; Chloroquine; Doxycycline; Ethanolamines; Fluorenes; Humans; India; Lumefantrine; Malaria, Falciparum; Mefloquine; Plasmodium falciparum; Quinine; Quinolines

2017
Emerging Southeast Asian PfCRT mutations confer Plasmodium falciparum resistance to the first-line antimalarial piperaquine.
    Nature communications, 2018, 08-17, Volume: 9, Issue:1

    Topics: Animals; Antimalarials; Cambodia; Cell Shape; Chloroquine; Drug Resistance; Gene Dosage; Gene Editing; Haplotypes; Humans; Malaria, Falciparum; Membrane Transport Proteins; Mutation; Parasites; Plasmodium falciparum; Protozoan Proteins; Quinolines; Verapamil

2018
[Diagnosis and Treatment of the First Imported Case of Plasmodium knowlesi Infection in China].
    Zhongguo ji sheng chong xue yu ji sheng chong bing za zhi = Chinese journal of parasitology & parasitic diseases, 2016, Volume: 34, Issue:6

    Topics: Animals; Antimalarials; Artemisinins; China; Chloroquine; Erythrocytes; Hemeproteins; Humans; Malaria; Microscopy; Plasmodium knowlesi; Polymerase Chain Reaction; Primaquine; Quinolines; Trophozoites

2016
Changing Molecular Markers of Antimalarial Drug Sensitivity across Uganda.
    Antimicrobial agents and chemotherapy, 2019, Volume: 63, Issue:3

    Topics: Antimalarials; Artemether, Lumefantrine Drug Combination; Artemisinins; Aspartic Acid Endopeptidases; Child; Chloroquine; Drug Resistance; Folic Acid Antagonists; Humans; Lumefantrine; Malaria, Falciparum; Membrane Transport Proteins; Multidrug Resistance-Associated Proteins; Plasmodium falciparum; Polymorphism, Single Nucleotide; Protozoan Proteins; Quinolines; Uganda

2019
Overexpression of plasmepsin II and plasmepsin III does not directly cause reduction in Plasmodium falciparum sensitivity to artesunate, chloroquine and piperaquine.
    International journal for parasitology. Drugs and drug resistance, 2019, Volume: 9

    Topics: Antimalarials; Artesunate; Aspartic Acid Endopeptidases; Cambodia; Chloroquine; Drug Resistance; Gene Dosage; Inhibitory Concentration 50; Microbial Sensitivity Tests; Plasmodium falciparum; Protozoan Proteins; Quinolines

2019
Susceptibility of Plasmodium falciparum to artemisinins and Plasmodium vivax to chloroquine in Phuoc Chien Commune, Ninh Thuan Province, south-central Vietnam.
    Malaria journal, 2019, Jan-17, Volume: 18, Issue:1

    Topics: Adolescent; Adult; Aged; Antimalarials; Child; Child, Preschool; Chloroquine; Drug Resistance, Multiple; Ethanolamines; Female; Fluorenes; Humans; Malaria, Falciparum; Malaria, Vivax; Male; Microbial Sensitivity Tests; Middle Aged; Plasmodium falciparum; Plasmodium vivax; Quinolines; Real-Time Polymerase Chain Reaction; Vietnam; Young Adult

2019
Structural and evolutionary analyses of the Plasmodium falciparum chloroquine resistance transporter.
    Scientific reports, 2020, 03-16, Volume: 10, Issue:1

    Topics: Amino Acids; Antimalarials; Chloroquine; Drug Resistance; Evolution, Molecular; Membrane Transport Proteins; Mutation; Parasitic Sensitivity Tests; Phylogeny; Plasmodium falciparum; Protozoan Proteins; Quinolines; Vacuoles

2020
Turning the tide: targeting PfCRT to combat drug-resistant P. falciparum?
    Nature reviews. Microbiology, 2020, Volume: 18, Issue:5

    Topics: Antimalarials; Chloroquine; Drug Resistance; Evolution, Molecular; Humans; Malaria, Falciparum; Membrane Transport Proteins; Mutant Proteins; Mutation, Missense; Plasmodium falciparum; Protozoan Proteins; Quinolines

2020
Ex-vivo Sensitivity of Plasmodium falciparum to Common Anti-malarial Drugs: The Case of Kéniéroba, a Malaria Endemic Village in Mali.
    Drugs in R&D, 2020, Volume: 20, Issue:3

    Topics: Adolescent; Amodiaquine; Antimalarials; Artemisinins; Child; Child, Preschool; Chloroquine; Drug Resistance; Endemic Diseases; Humans; Infant; Inhibitory Concentration 50; Lumefantrine; Malaria, Falciparum; Mali; Mefloquine; Plasmodium falciparum; Quinine; Quinolines

2020
Altered Drug Transport by
    Biochemistry, 2020, 07-14, Volume: 59, Issue:27

    Topics: Antimalarials; Biological Transport; Cell Culture Techniques; Chloroquine; Drug Resistance; Humans; Malaria, Falciparum; Membrane Transport Proteins; Models, Molecular; Mutation; Plasmodium falciparum; Protein Isoforms; Protozoan Proteins; Quinolines; Structure-Activity Relationship

2020
Balanced impacts of fitness and drug pressure on the evolution of PfMDR1 polymorphisms in Plasmodium falciparum.
    Malaria journal, 2021, Jun-30, Volume: 20, Issue:1

    Topics: Antimalarials; Chloroquine; Genetic Fitness; Haplotypes; Lumefantrine; Multidrug Resistance-Associated Proteins; Mutation; Plasmodium falciparum; Quinolines

2021
Longitudinal ex vivo and molecular trends of chloroquine and piperaquine activity against Plasmodium falciparum and P. vivax before and after introduction of artemisinin-based combination therapy in Papua, Indonesia.
    International journal for parasitology. Drugs and drug resistance, 2021, Volume: 17

    Topics: Antimalarials; Artemisinins; Chloroquine; Drug Resistance; Humans; Indonesia; Malaria, Falciparum; Plasmodium falciparum; Plasmodium vivax; Protozoan Proteins; Quinolines

2021
Evidence for the early emergence of piperaquine-resistant Plasmodium falciparum malaria and modeling strategies to mitigate resistance.
    PLoS pathogens, 2022, Volume: 18, Issue:2

    Topics: Alleles; Animals; Antimalarials; Artemisinins; Chloroquine; Computer Simulation; Drug Resistance, Multiple; Humans; Malaria, Falciparum; Membrane Transport Proteins; Piperazines; Plasmodium falciparum; Protozoan Proteins; Quinolines

2022
Evaluations of candidate markers of dihydroartemisinin-piperaquine resistance in Plasmodium falciparum isolates from the China-Myanmar, Thailand-Myanmar, and Thailand-Cambodia borders.
    Parasites & vectors, 2022, Apr-12, Volume: 15, Issue:1

    Topics: Antimalarials; Artemisinins; Biomarkers; Cambodia; Chloroquine; Drug Resistance; Humans; Malaria, Falciparum; Membrane Transport Proteins; Myanmar; Piperazines; Plasmodium falciparum; Protozoan Proteins; Quinolines; Thailand

2022
A single point mutation in the Plasmodium falciparum 3'-5' exonuclease does not alter piperaquine susceptibility.
    Malaria journal, 2022, Apr-22, Volume: 21, Issue:1

    Topics: Animals; Antimalarials; Chloroquine; DNA Copy Number Variations; Drug Resistance; Exonucleases; Malaria, Falciparum; Membrane Transport Proteins; Mutation; Parasites; Phosphodiesterase I; Piperazines; Plasmodium falciparum; Point Mutation; Protozoan Proteins; Quinolines

2022
Mutant PfCRT Can Mediate Piperaquine Resistance in African Plasmodium falciparum With Reduced Fitness and Increased Susceptibility to Other Antimalarials.
    The Journal of infectious diseases, 2022, 11-28, Volume: 226, Issue:11

    Topics: Antimalarials; Child, Preschool; Chloroquine; Drug Resistance; Gabon; Humans; Malaria, Falciparum; Plasmodium falciparum; Protozoan Proteins; Quinolines

2022
Piperaquine-resistant PfCRT mutations differentially impact drug transport, hemoglobin catabolism and parasite physiology in Plasmodium falciparum asexual blood stages.
    PLoS pathogens, 2022, Volume: 18, Issue:10

    Topics: Animals; Antimalarials; Artemisinins; Chloroquine; Drug Resistance; Heme; Hemoglobins; Humans; Malaria, Falciparum; Membrane Transport Proteins; Mutation; Parasites; Plasmodium falciparum; Protozoan Proteins

2022
PfCRT mutations conferring piperaquine resistance in falciparum malaria shape the kinetics of quinoline drug binding and transport.
    PLoS pathogens, 2023, Volume: 19, Issue:6

    Topics: Antimalarials; Chloroquine; Drug Resistance; Humans; Kinetics; Malaria, Falciparum; Mutation; Plasmodium falciparum; Protozoan Proteins; Quinolines

2023