piperaquine has been researched along with atovaquone in 13 studies
| Studies (piperaquine) | Trials (piperaquine) | Recent Studies (post-2010) (piperaquine) | Studies (atovaquone) | Trials (atovaquone) | Recent Studies (post-2010) (atovaquone) |
|---|---|---|---|---|---|
| 638 | 227 | 497 | 997 | 100 | 420 |
| Protein | Taxonomy | piperaquine (IC50) | atovaquone (IC50) |
|---|---|---|---|
| Dihydroorotate dehydrogenase | Schistosoma mansoni | 0.431 | |
| Cytochrome b | Homo sapiens (human) | 2.835 | |
| Dihydroorotate dehydrogenase (quinone), mitochondrial | Homo sapiens (human) | 2.65 | |
| Dihydroorotate dehydrogenase (quinone), mitochondrial | Rattus norvegicus (Norway rat) | 0.7 | |
| Broad substrate specificity ATP-binding cassette transporter ABCG2 | Homo sapiens (human) | 0.23 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (15.38) | 29.6817 |
| 2010's | 5 (38.46) | 24.3611 |
| 2020's | 6 (46.15) | 2.80 |
| Authors | Studies |
|---|---|
| Fidock, DA; Flannery, EL; Winzeler, EA | 1 |
| Bane, CE; Black, C; Butler, K; Caridha, D; Cooper, RA; Dodean, RA; Gaona, H; Gaynor-Ohnstad, L; Huezo, SJ; Kancharla, P; Kelly, JX; Kreishman-Deitrick, M; Leed, SE; Li, Q; Li, Y; Lin, H; Luong, TL; Marcsisin, S; Melendez, V; Nolan, C; Olmeda, R; Potter, B; Pou, S; Rasmussen, SA; Read, L; Riscoe, MK; Roncal, N; Sciotti, RJ; Smilkstein, MJ; Sousa, J; Stephens, MT; Tan, JC; Vesely, B; Vuong, C; Winter, RW; Xie, L; Zeng, Q; Zhang, J; Zhang, P | 1 |
| Cheong, SL; Ng, CH; Tibon, NS | 1 |
| Bane, CE; Bayles, BR; Black, C; Butler, K; Caridha, D; Ceja, FG; Cooper, RA; Dodean, RA; Gaona, H; Gaynor-Ohnstad, L; Kancharla, P; Kelly, JX; Kreishman-Deitrick, M; Leed, SE; Li, Q; Li, Y; Lin, H; Luong, TL; Marcsisin, S; Melendez, V; Mu, J; Nolan, C; Olmeda, R; Potter, B; Pou, S; Pybus, B; Rasmussen, SA; Read, L; Reynolds, KA; Riscoe, MK; Roncal, N; Rosenthal, PJ; Sciotti, RJ; Smilkstein, MJ; Sousa, J; Tumwebaze, PK; Vesely, B; Vuong, C; Xie, L; Zeng, Q; Zhang, J; Zhang, P | 1 |
| Binh, TQ; de Vries, PJ; Giao, PT; Hung, le Q; Kager, PA; Nam, NV | 1 |
| Chollet, J; Santo-Tomas, J; Scheurer, C; Snyder, C; Wittlin, S | 1 |
| Bellettre, X; Bouchaud, O; Michel, JF; Pull, L; Siriez, JY | 1 |
| Chann, S; Chaorattanakawee, S; Chuor, CM; Gosi, P; Gregory, C; Ittiverakul, M; Kuntawunginn, W; Lanteri, C; Lon, C; Prom, S; Saunders, DL; Somethy, S; Spring, MD | 1 |
| Agarwal, P; Anvikar, AR; Pillai, CR; Srivastava, K | 1 |
| Garrido Jareño, M; Otero Reigada, MDC; Peman García, J; Ramírez Cuentas, JH; Roselló Guijarro, M; Urtasun Erburu, A | 1 |
| Chibale, K; Fidock, DA; Goldberg, DE; Istvan, ES; Lee, MCS; Llinás, M; Murithi, JM; Ottilie, S; Owen, ES; Vanaerschot, M; Winzeler, EA | 1 |
| Amalvict, R; Benoit, N; Chevalier, A; Delaunay, P; Fonta, I; Jeandel, PY; Madamet, M; Marty, P; Massamba, L; Mondain, V; Mosnier, J; Pomares, C; Pradines, B | 1 |
| Anvikar, AR; Ashley, EA; Chandramohan, D; Cohee, LM; D'Alessandro, U; Genton, B; Gilder, ME; Guérin, PJ; Juma, E; Kalilani-Phiri, L; Kennon, K; Kuepfer, I; Laufer, MK; Lwin, KM; Mansoor, R; McGready, R; Meshnick, SR; Mosha, D; Mwapasa, V; Mwebaza, N; Nambozi, M; Ndiaye, JA; Nosten, F; Nyunt, M; Ogutu, B; Parikh, S; Paw, MK; Phyo, AP; Pimanpanarak, M; Piola, P; Rijken, MJ; Saito, M; Sriprawat, K; Stepniewska, K; Tagbor, HK; Tarning, J; Tinto, H; Valéa, I; Valecha, N; White, NJ; Wiladphaingern, J | 1 |
3 review(s) available for piperaquine and atovaquone
| Article | Year |
|---|---|
Using genetic methods to define the targets of compounds with antimalarial activity.
Topics: Animals; Anopheles; Antimalarials; Drug Resistance; Genetic Association Studies; Genome, Protozoan; Humans; Malaria, Falciparum; Molecular Targeted Therapy; Plasmodium falciparum | 2013 |
Current progress in antimalarial pharmacotherapy and multi-target drug discovery.
Topics: Animals; Antimalarials; Artemisinins; Drug Discovery; Drug Resistance; Humans; Malaria; Molecular Structure; Paclitaxel; Quinolines | 2020 |
Efficacy and tolerability of artemisinin-based and quinine-based treatments for uncomplicated falciparum malaria in pregnancy: a systematic review and individual patient data meta-analysis.
Topics: Amodiaquine; Anti-Bacterial Agents; Antimalarials; Artemisinins; Artesunate; Atovaquone; Clindamycin; Drug Combinations; Drug Therapy, Combination; Female; Humans; Malaria, Falciparum; Mefloquine; Pregnancy; Pregnancy Complications, Parasitic; Proguanil; Pyrimethamine; Quinine; Quinolines; Sulfadoxine | 2020 |
1 trial(s) available for piperaquine and atovaquone
| Article | Year |
|---|---|
CV8, a new combination of dihydroartemisinin, piperaquine, trimethoprim and primaquine, compared with atovaquone-proguanil against falciparum malaria in Vietnam.
Topics: Adolescent; Adult; Aged; Animals; Antimalarials; Artemisinins; Atovaquone; Drug Combinations; Drug Therapy, Combination; Female; Humans; Malaria, Falciparum; Male; Middle Aged; Naphthoquinones; Parasitemia; Plasmodium falciparum; Primaquine; Proguanil; Quinolines; Sesquiterpenes; Treatment Outcome; Trimethoprim; Vietnam | 2004 |
9 other study(ies) available for piperaquine and atovaquone
| Article | Year |
|---|---|
Discovery and Structural Optimization of Acridones as Broad-Spectrum Antimalarials.
Topics: Acridones; Animals; Antimalarials; Disease Models, Animal; Drug Discovery; Hep G2 Cells; Humans; Malaria; Mice; Plasmodium; Species Specificity; Structure-Activity Relationship | 2019 |
Lead Optimization of Second-Generation Acridones as Broad-Spectrum Antimalarials.
Topics: Acridones; Administration, Oral; Animals; Antimalarials; Cell Survival; Disease Models, Animal; Female; Half-Life; Hep G2 Cells; Humans; Life Cycle Stages; Malaria; Male; Mice; Mice, Inbred C57BL; Plasmodium falciparum; Structure-Activity Relationship | 2020 |
In vitro and in vivo interaction of synthetic peroxide RBx11160 (OZ277) with piperaquine in Plasmodium models.
Topics: Animals; Antimalarials; Artemether; Artemisinins; Atovaquone; Disease Models, Animal; Drug Interactions; Drug Therapy, Combination; Erythrocytes; Female; Heterocyclic Compounds, 1-Ring; Humans; Malaria; Mice; Parasitemia; Parasitic Sensitivity Tests; Peroxides; Plasmodium berghei; Plasmodium falciparum; Pyrimethamine; Quinolines; Spiro Compounds | 2007 |
[Treatment of severe and uncomplicated falciparum malaria in children in France].
Topics: Antimalarials; Artemether, Lumefantrine Drug Combination; Artemisinins; Artesunate; Atovaquone; Child; Drug Combinations; Ethanolamines; Fluorenes; France; Humans; Malaria, Falciparum; Proguanil; Quinolines | 2013 |
Atovaquone-Proguanil Remains a Potential Stopgap Therapy for Multidrug-Resistant Plasmodium falciparum in Areas along the Thai-Cambodian Border.
Topics: Antimalarials; Artemisinins; Atovaquone; Base Sequence; Cambodia; DNA, Protozoan; Drug Combinations; Drug Resistance, Multiple; Humans; Malaria, Falciparum; Parasitic Sensitivity Tests; Plasmodium falciparum; Proguanil; Quinolines; Sequence Analysis, DNA; Thailand | 2015 |
Topics: Anti-Bacterial Agents; Antimalarials; Artemether; Artemisinins; Atovaquone; Azithromycin; Chloroquine; Doxycycline; Ethanolamines; Fluorenes; Humans; India; Lumefantrine; Malaria, Falciparum; Mefloquine; Plasmodium falciparum; Quinine; Quinolines | 2017 |
[Descriptive study of malaria cases in the paediatric population in a reference hospital in Valencia, Spain, between 1993 and 2015].
Topics: Adolescent; Age Distribution; Antimalarials; Artemisinins; Artesunate; Atovaquone; Child; Child, Preschool; Drug Combinations; Equatorial Guinea; Female; Hospitals, Community; Humans; Infant; Malaria; Male; Proguanil; Quinine; Quinolines; Retrospective Studies; Sex Distribution; Spain; Symptom Assessment | 2020 |
Combining Stage Specificity and Metabolomic Profiling to Advance Antimalarial Drug Discovery.
Topics: Antimalarials; Atovaquone; Drug Design; Electron Transport Chain Complex Proteins; Humans; Life Cycle Stages; Malaria, Falciparum; Metabolome; Metabolomics; Mitochondria; Plasmodium falciparum; Quinolines | 2020 |
Late clinical failure associated with cytochrome b codon 268 mutation during treatment of falciparum malaria with atovaquone-proguanil in traveller returning from Congo.
Topics: Antimalarials; Artemisinins; Atovaquone; Codon; Congo; Cytochromes b; Drug Combinations; Drug Resistance; Female; France; Humans; Malaria, Falciparum; Middle Aged; Mutation; Phenanthrenes; Plasmodium falciparum; Proguanil; Quinolines; Tetrahydrofolate Dehydrogenase; Travel | 2020 |