Compounds > pipequaline
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pipequaline and diazepam

pipequaline has been researched along with diazepam in 11 studies

Research

Studies (11)

TimeframeStudies, this research(%)All Research%
pre-199011 (100.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Essassi, D; Hamberger, C; Rougeot, C; Tillement, JP; Urien, S; Uzan, A; Zini, R1
Eves, FF; Lader, MH1
Curran, HV; Eves, FF; Lader, MH; Shine, P1
Ansseau, M; Bonnet, D; von Frenckell, R1
Daniel, M; Dubroeucq, MC; Gauthier, A; Gueremy, C; Mazadier, M; Mizoule, J; Ollat, C; Rataud, J; Renault, C; Uzan, A1
Le Fur, G1
File, SE; Lister, RG1
Keane, PE; Morre, M; Simiand, J1
File, SE1
Burgevin, MC; Ferris, O; Gauthier, A; Guérémy, C; Heaulme, M; Le Fur, G; Mizoule, J; Uzan, A1
Brinton, RE; Gee, KW; Yamamura, HI1

Trials

3 trial(s) available for pipequaline and diazepam

ArticleYear
The effects of alcohol on psychological functions in normal volunteers after 8 days' treatment with pipequaline (PK 8165), diazepam or placebo.
    European journal of clinical pharmacology, 1989, Volume: 36, Issue:1

    Topics: Adult; Diazepam; Double-Blind Method; Drug Interactions; Ethanol; Female; Humans; Male; Memory, Short-Term; Middle Aged; Psychomotor Performance; Quinolines; Reaction Time; Speech Articulation Tests; Wechsler Scales

1989
The effects on memory of pipequaline, alone or in combination with diazepam.
    Psychopharmacology, 1988, Volume: 95, Issue:3

    Topics: Adult; Anticonvulsants; Cognition; Diazepam; Double-Blind Method; Emotions; Female; Humans; Male; Memory; Psychomotor Performance; Quinolines

1988
Evaluation of the sedative properties of PK 8165 (pipequaline), a benzodiazepine partial agonist, in normal subjects.
    International clinical psychopharmacology, 1986, Volume: 1, Issue:1

    Topics: Adult; Diazepam; Double-Blind Method; Drug Evaluation; Female; Humans; Hypnotics and Sedatives; Male; Psychomotor Performance; Quinolines; Wakefulness

1986

Other Studies

8 other study(ies) available for pipequaline and diazepam

ArticleYear
Binding in vitro of pipequaline (45319 RP) onto plasma proteins and blood cells in man.
    Biochemical pharmacology, 1987, Oct-15, Volume: 36, Issue:20

    Topics: Adult; Anti-Anxiety Agents; Blood Cells; Blood Proteins; Diazepam; Erythrocytes; Fatty Acids, Nonesterified; Female; Humans; In Vitro Techniques; Lipoproteins; Male; Protein Binding; Quinolines; Serum Albumin; Tissue Distribution; Warfarin

1987
Pharmacological evidence that PK 8165 behaves as a partial agonist of brain type benzodiazepine receptors.
    Archives internationales de pharmacodynamie et de therapie, 1984, Volume: 271, Issue:2

    Topics: Aggression; Animals; Anticonvulsants; Benzodiazepinones; Conflict, Psychological; Diazepam; Drinking; Flumazenil; Humans; Male; Mice; Mice, Inbred Strains; Phenobarbital; Quinolines; Receptors, GABA-A; Reflex

1984
[Anxiety receptors: new pharmacological approach (author's transl)].
    L'Encephale, 1982, Volume: 8, Issue:2

    Topics: Animals; Anti-Anxiety Agents; Anxiety Disorders; Binding, Competitive; Brain; Chlordiazepoxide; Chlorides; Diazepam; gamma-Aminobutyric Acid; Humans; Quinolines; Receptors, Cell Surface; Receptors, Drug; Receptors, GABA-A; Seizures

1982
Quinolines and anxiety: anxiogenic effects of CGS 8216 and partial anxiolytic profile of PK 9084.
    Pharmacology, biochemistry, and behavior, 1983, Volume: 18, Issue:2

    Topics: Animals; Anti-Anxiety Agents; Anxiety; Chlordiazepoxide; Diazepam; Humans; Male; Motor Activity; Pyrazoles; Quinolines; Rats; Social Behavior

1983
The quinolines PK 8165 and PK 9084 possess benzodiazepine-like activity in vitro but not in vivo.
    Neuroscience letters, 1984, Mar-09, Volume: 45, Issue:1

    Topics: Animals; Anti-Anxiety Agents; Benzodiazepines; Brain; Diazepam; Flunitrazepam; gamma-Aminobutyric Acid; In Vitro Techniques; Mice; Quinolines; Rats; Receptors, Cell Surface; Receptors, GABA-A

1984
Modification of seizures elicited by the benzodiazepine Ro 5-3663--a comparison with picrotoxin.
    The Journal of pharmacy and pharmacology, 1984, Volume: 36, Issue:12

    Topics: Animals; Benzodiazepinones; Chemical Phenomena; Chemistry; Convulsants; Diazepam; Drug Synergism; Flumazenil; Male; Mice; Picrotoxin; Pyrazoles; Quinolines; Seizures

1984
Multiple benzodiazepine receptors: evidence of dissociation between anticonflict and anticonvulsant properties by PK 8165 and PK 9084 (two quinoline derivatives).
    Life sciences, 1981, Mar-30, Volume: 28, Issue:13

    Topics: Animals; Azabicyclo Compounds; Benzodiazepines; Binding, Competitive; Cerebellar Cortex; Chlordiazepoxide; Conflict, Psychological; Cyclic AMP; Cyclic GMP; Diazepam; Hypnotics and Sedatives; Kinetics; Male; Motor Activity; Piperazines; Quinolines; Rats; Receptors, Drug; Receptors, GABA-A

1981
PK 8165 and PK 9084, two quinoline derivatives with anxiolytic properties, antagonize the anticonvulsant effects of diazepam.
    Brain research, 1983, Mar-28, Volume: 264, Issue:1

    Topics: Animals; Anticonvulsants; Benzodiazepines; Bicuculline; Brain; Diazepam; Drug Antagonism; Flunitrazepam; gamma-Aminobutyric Acid; Male; Mice; Quinolines; Receptors, Cell Surface; Receptors, GABA-A; Seizures

1983