Page last updated: 2024-08-16

pioglitazone and transforming growth factor beta

pioglitazone has been researched along with transforming growth factor beta in 41 studies

Research

Studies (41)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	21 (51.22)	29.6817
2010's	16 (39.02)	24.3611
2020's	4 (9.76)	2.80

Authors

Authors	Studies
Haneda, M; Isshiki, K; Kikkawa, R; Koya, D; Maeda, S; Sugimoto, T	1
Egashira, K; Hiasa, K; Ichiki, T; Inoue, S; Ishibashi, M; Kitamoto, S; Ni, W; Takeshita, A; Usui, M; Zhao, Q	1
Guo, B; Haneda, M; Isono, M; Kashiwagi, A; Koya, D; Sugimoto, T	1
Polhill, TS; Pollock, CA; Poronnik, P; Stanners, SR; Zafiriou, S	1
Chen, XM; Panchapakesan, U; Pollock, CA	1
Thiemermann, C	1
Polhill, TS; Pollock, CA; Poronnik, P; Saad, S; Stanners, SR; Zafiriou, S	1
Padilla, E; Redondo, S; Ruiz, E; Santos-Gallego, CG; Tejerina, T	1
Chen, X; Panchapakesan, U; Pollock, CA; Sumual, S	1
Gohda, T; Horikoshi, S; Maeda, A; Maeda, K; Tomino, Y; Tsuge, T	1
Eiam-Ong, S; Katavetin, P; Suwanwalaikorn, S	1
Game, BA; He, L; Huang, Y; Jaffa, AA; Jarido, V; Lopes-Virella, MF; Nareika, A	1
Acampado, E; Burke, AP; Cheng, Q; Creighton, W; Farb, A; Finn, AV; Gold, HK; Joner, M; Kolodgie, FD; Skorija, K; Virmani, R	1
Makino, H; Ogawa, D; Ohga, S; Okada, S; Shikata, K; Shikata, Y; Usui, H; Wada, J; Yozai, K	1
Akahori, H; Kaneko, S; Kita, Y; Kurita, S; Matsuzawa, N; Misu, H; Nakanuma, Y; Ota, T; Sakurai, M; Takamura, T; Uno, M; Zen, Y	1
Chen, WH; Jia, JB; Liu, M; Liu, Y; Lu, LG	1
Chen, J; Fogo, AB; Guan, Y; Kanjanabuch, T; Ma, LJ; Mundel, P; Pozzi, A	1
Izuhara, Y; Kakuta, T; Miyata, T; Ohtomo, S; Takizawa, S; van Ypersele de Strihou, C; Yamada, N	1
Li, XP; Liu, LP; Shen, XQ; Zhang, M; Zhao, S; Zhou, SH	1
Hirasawa, Y; Ito, M; Kawasaki, Y; Kyuki, K; Matsui, Y; Nagamatsu, T; Sakai, T; Toyoshi, T; Yabuki, SY; Yamane, K	1
Aoki, F; Aoki, N; Aoki, Y; Aoyagi, K; Arai, M; Kurabayashi, M; Maeno, T; Nakagawa, J; Sando, Y; Shimizu, Y; Suga, T; Ueno, M	1
Fan, JM; Pu, L	1
Higashi, K; Hyodo, T; Kumagai, H; Kushiyama, T; Miura, S; Oda, T; Sakurai, Y; Suzuki, S; Yamada, M	1
Chen, JS; Pan, HW; Xu, JT	1
Aukema, HM; Calvet, JP; Hiki, Y; Kugita, M; Kurahashi, H; Morita, M; Nagao, S; Wallace, DP; Yamaguchi, T; Yoshihara, D	1
Feldon, SE; Guo, N; Phipps, RP; Woeller, CF	1
Camsari, T; Cavdar, Z; Kolatan, E; Oktay, G; Saglam, F; Sarioglu, S; Yilmaz, O	1
Araki, N; Asakura, J; Hasegawa, H; Iwashita, T; Kanozawa, K; Matsuda, A; Mitarai, T; Shimazu, T; Shimizu, T; Suge, R; Takayanagi, K; Tayama, Y	1
Li, M; Li, R; Li, Y; Liang, X; Shen, Y; Su, D; Xu, W	1
Baumbach, GL; Brooks, RM; Chen, B; Chu, Y; Davis, MK; Doshi, H; El Accaoui, RN; Funk, ND; Hajj, GP; Hameed, T; Heistad, DD; Leinwand, LA; Lund, DD; Magida, JA; Song, LS; Weiss, RM; Zimmerman, KA	1
Armstrong, EA; Gao, X; Jacobs, RL; Kassiri, Z; Lehner, R; Lingrell, S; Quiroga, AD; Takawale, A; van der Veen, JN; Vance, DE; Yager, JY	1
Huang, S; Li, Q; Liu, YY; Wang, J; Wang, K; Xu, G; Zhan, J; Zhang, CH; Zhang, Y; Zhou, QD	1
Chen, A; Cheng, AM; Chuang, MC; He, H; Liao, SL; Liu, YW; Sheha, H; Tighe, S; Yin, HY	1
Deng, W; Li, LL; Ma, ZG; Tang, QZ; Wei, WY; Xu, M; Yuan, YP; Zhang, N	1
Al-Shorbagy, MY; Ali, RM; El-Abhar, HS; Helmy, MW	1
Arita, T; Asai, J; Jo, JI; Kanemaru, M; Katoh, N; Kawai-Ohnishi, M; Tabata, Y; Tsutsumi, M; Wada, M	1
Calvier, L; Hansmann, G; Kökény, G; Mózes, MM; Németh, Á	1
Amin, F; Boskabady, MH; Kazerani, HR; Memarzia, A; Rad, HK	1
Calvier, L; Hansmann, G; Kökény, G	1
Chuang, TD; Kurihara, C; Rehan, VK; Sakurai, R; Walther, FJ; Waring, AJ	1
Amano, R; Hosokawa, Y; Hosooka, T; Imamori, M; Imi, Y; Kasahara, N; Kishino, S; Kunisawa, J; Ogawa, J; Ogawa, W; Okada, K; Shinohara, M; Tomimoto, C	1

Reviews

1 review(s) available for pioglitazone and transforming growth factor beta

Article	Year
PPARγ and TGFβ-Major Regulators of Metabolism, Inflammation, and Fibrosis in the Lungs and Kidneys. International journal of molecular sciences, 2021, Sep-28, Volume: 22, Issue:19 Topics: Animals; Humans; Kidney; Lung; Pioglitazone; PPAR gamma; Pulmonary Arterial Hypertension; Pulmonary Fibrosis; Renal Insufficiency; Signal Transduction; Transforming Growth Factor beta	2021

Trials

1 trial(s) available for pioglitazone and transforming growth factor beta

Article	Year
Pioglitazone reduces urinary protein and urinary transforming growth factor-beta excretion in patients with type 2 diabetes and overt nephropathy. Journal of the Medical Association of Thailand = Chotmaihet thangphaet, 2006, Volume: 89, Issue:2 Topics: Administration, Oral; Aged; Blood Glucose; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Dose-Response Relationship, Drug; Female; Humans; Hypoglycemic Agents; Kidney Function Tests; Male; Middle Aged; Pioglitazone; Probability; Proteinuria; Reference Values; Risk Assessment; Sensitivity and Specificity; Severity of Illness Index; Single-Blind Method; Thiazolidinediones; Transforming Growth Factor beta; Treatment Outcome	2006

Article

Year

Pioglitazone reduces urinary protein and urinary transforming growth factor-beta excretion in patients with type 2 diabetes and overt nephropathy.

Journal of the Medical Association of Thailand = Chotmaihet thangphaet, 2006, Volume: 89, Issue:2

Topics: Administration, Oral; Aged; Blood Glucose; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Dose-Response Relationship, Drug; Female; Humans; Hypoglycemic Agents; Kidney Function Tests; Male; Middle Aged; Pioglitazone; Probability; Proteinuria; Reference Values; Risk Assessment; Sensitivity and Specificity; Severity of Illness Index; Single-Blind Method; Thiazolidinediones; Transforming Growth Factor beta; Treatment Outcome

2006

Other Studies

39 other study(ies) available for pioglitazone and transforming growth factor beta

Article	Year
Thiazolidinedione compounds ameliorate glomerular dysfunction independent of their insulin-sensitizing action in diabetic rats. Diabetes, 2000, Volume: 49, Issue:6 Topics: Albuminuria; Animals; Chromans; Diabetes Mellitus, Experimental; Diglycerides; Extracellular Matrix Proteins; Hemodynamics; Insulin; Kidney Glomerulus; Male; Mitogen-Activated Protein Kinases; Pioglitazone; Protein Kinase C; Rats; Rats, Sprague-Dawley; Renal Circulation; RNA, Messenger; Thiazoles; Thiazolidinediones; Transforming Growth Factor beta; Troglitazone	2000
Antiinflammatory and antiarteriosclerotic effects of pioglitazone. Hypertension (Dallas, Tex. : 1979), 2002, Volume: 40, Issue:5 Topics: Animals; Anti-Inflammatory Agents; Arteriosclerosis; Blood Glucose; Blood Pressure; Chemokine CCL2; Coronary Artery Disease; Disease Models, Animal; Drug Evaluation, Preclinical; Inflammation; Insulin; Lipids; Male; Monocytes; Myocardium; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Peptidyl-Dipeptidase A; Pioglitazone; Rats; Rats, Inbred WKY; Receptors, CCR2; Receptors, Chemokine; Receptors, Cytoplasmic and Nuclear; RNA, Messenger; Thiazoles; Thiazolidinediones; Transcription Factors; Transforming Growth Factor beta; Transforming Growth Factor beta1; Treatment Outcome	2002
Peroxisome proliferator-activated receptor-gamma ligands inhibit TGF-beta 1-induced fibronectin expression in glomerular mesangial cells. Diabetes, 2004, Volume: 53, Issue:1 Topics: Animals; Base Sequence; Blotting, Northern; Cells, Cultured; Consensus Sequence; DNA Primers; Fibronectins; Glomerular Mesangium; Humans; Hypoglycemic Agents; Ligands; Mice; Mice, Transgenic; Pioglitazone; Receptors, Cytoplasmic and Nuclear; Recombinant Proteins; RNA, Messenger; Signal Transduction; Simian virus 40; Thiazolidinediones; Transcription Factor AP-1; Transcription Factors; Transcription, Genetic; Transforming Growth Factor beta	2004
Pioglitazone increases renal tubular cell albumin uptake but limits proinflammatory and fibrotic responses. Kidney international, 2004, Volume: 65, Issue:5 Topics: Albumins; Animals; Biological Transport, Active; Cell Division; Cells, Cultured; Chemokine CCL2; Fibrosis; Genes, Reporter; Inflammation; Kidney Tubules; NF-kappa B; Opossums; Pioglitazone; PPAR gamma; Proteinuria; Thiazolidinediones; Transforming Growth Factor beta; Transforming Growth Factor beta1	2004
The effect of high glucose and PPAR-gamma agonists on PPAR-gamma expression and function in HK-2 cells. American journal of physiology. Renal physiology, 2004, Volume: 287, Issue:3 Topics: Cell Line; Cell Survival; Chemokine CCL2; Cyclin-Dependent Kinase Inhibitor p21; Cyclins; Diabetic Nephropathies; Flow Cytometry; Glucose; Humans; Hypoglycemic Agents; Kidney Tubules, Proximal; Pioglitazone; Promoter Regions, Genetic; Receptors, Cytoplasmic and Nuclear; Thiazolidinediones; Thymidine; Transcription Factor AP-1; Transcription Factors; Transforming Growth Factor beta; Transforming Growth Factor beta1; Tritium	2004
Ligands of the peroxisome proliferator-activated receptor-gamma and heart failure. British journal of pharmacology, 2004, Volume: 142, Issue:6 Topics: Animals; Chemokine CCL2; Diabetes Mellitus, Type 2; Disease Models, Animal; Heart Diseases; Humans; Hypoglycemic Agents; Ligands; Mice; Myocardial Infarction; Pioglitazone; PPAR gamma; Rats; Thiazolidinediones; Transforming Growth Factor beta; Treatment Outcome; Tumor Necrosis Factor-alpha	2004
Pioglitazone inhibits cell growth and reduces matrix production in human kidney fibroblasts. Journal of the American Society of Nephrology : JASN, 2005, Volume: 16, Issue:3 Topics: Cell Death; Cell Division; Collagen Type IV; Extracellular Matrix; Fibroblasts; Fibronectins; Gene Expression; Glucose; Humans; Hypoglycemic Agents; In Vitro Techniques; Kidney Cortex; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Pioglitazone; PPAR gamma; Proline; Thiazolidinediones; Tissue Inhibitor of Metalloproteinase-1; Tissue Inhibitor of Metalloproteinase-2; Transforming Growth Factor beta; Transforming Growth Factor beta1	2005
Pioglitazone induces vascular smooth muscle cell apoptosis through a peroxisome proliferator-activated receptor-gamma, transforming growth factor-beta1, and a Smad2-dependent mechanism. Diabetes, 2005, Volume: 54, Issue:3 Topics: Animals; Apoptosis; Cell Proliferation; Cells, Cultured; DNA-Binding Proteins; Gene Expression; Hypoglycemic Agents; Muscle, Smooth, Vascular; Pioglitazone; PPAR gamma; Rats; Smad2 Protein; Thiazolidinediones; Time Factors; Trans-Activators; Transforming Growth Factor beta	2005
PPARgamma agonists exert antifibrotic effects in renal tubular cells exposed to high glucose. American journal of physiology. Renal physiology, 2005, Volume: 289, Issue:5 Topics: Cell Culture Techniques; Cell Proliferation; Fibrosis; Glucose; Humans; Hyperglycemia; Hypoglycemic Agents; Inflammation; Insulin Resistance; Kidney; Kidney Tubules, Proximal; Lipid Metabolism; Pioglitazone; PPAR gamma; Thiazolidinediones; Transcription Factor AP-1; Transforming Growth Factor beta; Transforming Growth Factor beta1	2005
Pioglitazone attenuates TGF-beta(1)-induction of fibronectin synthesis and its splicing variant in human mesangial cells via activation of peroxisome proliferator-activated receptor (PPAR)gamma. Cell biology international, 2005, Volume: 29, Issue:6 Topics: Alternative Splicing; Cells, Cultured; Fibronectins; Glomerular Mesangium; Humans; Pioglitazone; PPAR gamma; Thiazolidinediones; Transforming Growth Factor beta; Up-Regulation	2005
Pioglitazone inhibits connective tissue growth factor expression in advanced atherosclerotic plaques in low-density lipoprotein receptor-deficient mice. Atherosclerosis, 2007, Volume: 192, Issue:1 Topics: Animals; Aorta; Atherosclerosis; Cells, Cultured; Connective Tissue Growth Factor; Diet, Atherogenic; Disease Models, Animal; Down-Regulation; Humans; Hypoglycemic Agents; Immediate-Early Proteins; Intercellular Signaling Peptides and Proteins; Male; Mice; Myocytes, Smooth Muscle; Pioglitazone; Receptors, LDL; Thiazolidinediones; Transforming Growth Factor beta	2007
Pioglitazone inhibits in-stent restenosis in atherosclerotic rabbits by targeting transforming growth factor-beta and MCP-1. Arteriosclerosis, thrombosis, and vascular biology, 2007, Volume: 27, Issue:1 Topics: Administration, Oral; Animals; Atherosclerosis; Cell Proliferation; Cells, Cultured; Chemokine CCL2; Coronary Restenosis; Dose-Response Relationship, Drug; Gene Expression Regulation; Hypoglycemic Agents; Macrophages; Mice; Organ Culture Techniques; Pioglitazone; Rabbits; Random Allocation; Stents; Thiazolidinediones; Transforming Growth Factor beta; Tunica Intima	2007
Thiazolidinedione ameliorates renal injury in experimental diabetic rats through anti-inflammatory effects mediated by inhibition of NF-kappaB activation. American journal of physiology. Renal physiology, 2007, Volume: 292, Issue:4 Topics: Anilides; Animals; Anti-Inflammatory Agents; Cells, Cultured; Collagen Type IV; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Humans; Intercellular Adhesion Molecule-1; Kidney Glomerulus; Macrophage Activation; Male; NF-kappa B; Pioglitazone; PPAR gamma; Pyrrolidines; Rats; Rats, Sprague-Dawley; Thiazolidinediones; Thiocarbamates; Transforming Growth Factor beta	2007
Insulin resistance accelerates a dietary rat model of nonalcoholic steatohepatitis. Gastroenterology, 2007, Volume: 132, Issue:1 Topics: Animal Feed; Animals; Choline; Collagen Type I; Collagen Type I, alpha 1 Chain; Diabetes Mellitus, Type 2; Dietary Fats; Disease Models, Animal; Fatty Liver; Hyperinsulinism; Hypoglycemic Agents; Insulin Resistance; Liver; Male; Methionine; Obesity; Pioglitazone; Plasminogen Activator Inhibitor 1; PPAR gamma; Rats; Rats, Inbred OLETF; Rats, Long-Evans; RNA, Messenger; Sterol Regulatory Element Binding Protein 1; Thiazolidinediones; Transforming Growth Factor beta; Up-Regulation	2007
[Effects of pioglitazone on the morphology and the expression of connective tissue growth factor of transforming growth factor beta-induced rat hepatic stellate cells in vitro]. Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology, 2007, Volume: 15, Issue:3 Topics: Animals; Cells, Cultured; Collagen Type III; Connective Tissue Growth Factor; Hepatic Stellate Cells; Pioglitazone; Rats; Thiazolidinediones; Transforming Growth Factor beta	2007
PPAR-gamma agonist protects podocytes from injury. Kidney international, 2007, Volume: 71, Issue:12 Topics: Animals; Apoptosis; bcl-X Protein; Caspase Inhibitors; Cell Proliferation; Cells, Cultured; Cyclin-Dependent Kinase Inhibitor p27; Kidney Glomerulus; Mice; Necrosis; Pioglitazone; Plasmids; Podocytes; PPAR gamma; Puromycin Aminonucleoside; RNA, Messenger; Thiazolidinediones; Transforming Growth Factor beta	2007
Thiazolidinediones provide better renoprotection than insulin in an obese, hypertensive type II diabetic rat model. Kidney international, 2007, Volume: 72, Issue:12 Topics: Animals; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Disease Models, Animal; Glycation End Products, Advanced; Hyperinsulinism; Hypertension, Renal; Hypoglycemic Agents; Insulin; Kidney; Male; Obesity; Oxidative Stress; Pioglitazone; Proteinuria; Rats; Rats, Inbred SHR; Rats, Inbred WKY; RNA, Messenger; Thiazolidinediones; Transforming Growth Factor beta	2007
Pioglitazone can downregulate bone morphogenetic protein-2 expression induced by high glucose in human umbilical vein endothelial cells. Pharmacology, 2008, Volume: 81, Issue:4 Topics: Bone Morphogenetic Protein 2; Bone Morphogenetic Proteins; Down-Regulation; Endothelial Cells; Endothelium, Vascular; Glucose; Humans; Hypoglycemic Agents; Malondialdehyde; NF-kappa B; Pioglitazone; Superoxide Dismutase; Thiazolidinediones; Transforming Growth Factor beta; Umbilical Veins	2008
Pioglitazone improves obesity type diabetic nephropathy: relation to the mitigation of renal oxidative reaction. Experimental animals, 2008, Volume: 57, Issue:5 Topics: 8-Hydroxy-2'-Deoxyguanosine; Animals; Blood Glucose; Cholesterol; Cystatin C; Cystatins; Diabetic Nephropathies; Glycated Hemoglobin; Guanine; Hypoglycemic Agents; Insulin; Kidney; Malondialdehyde; Obesity; Oxidation-Reduction; Phospholipids; Pioglitazone; Rats; Rats, Zucker; Receptor for Advanced Glycation End Products; Receptors, Immunologic; Thiazolidinediones; Transforming Growth Factor beta; Triglycerides	2008
Pioglitazone, a peroxisome proliferator-activated receptor gamma ligand, suppresses bleomycin-induced acute lung injury and fibrosis. Respiration; international review of thoracic diseases, 2009, Volume: 77, Issue:3 Topics: Acute Lung Injury; Animals; Bleomycin; Cells, Cultured; Collagen Type I; Connective Tissue Growth Factor; Fibroblasts; Fibrosis; Humans; Hypoglycemic Agents; Lung; Macrophages, Alveolar; Male; Pioglitazone; PPAR gamma; Rats; Rats, Wistar; Thiazolidinediones; Transforming Growth Factor beta; Tumor Necrosis Factor-alpha	2009
[Effects of pioglitazone on the transdifferentiation and CTGF expression of renal tubular epithelial-myofibroblast in vitro]. Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition, 2010, Volume: 41, Issue:1 Topics: Animals; Cell Differentiation; Cell Line; Cell Transdifferentiation; Connective Tissue Growth Factor; Epithelial Cells; Kidney Tubules, Proximal; Myofibroblasts; Pioglitazone; Rats; RNA, Messenger; Thiazolidinediones; Transforming Growth Factor beta	2010
Additive antifibrotic effects of pioglitazone and candesartan on experimental renal fibrosis in mice. Nephrology (Carlton, Vic.), 2010, Volume: 15, Issue:3 Topics: Adiponectin; Angiotensin II Type 1 Receptor Blockers; Animals; Benzimidazoles; Biomarkers; Biphenyl Compounds; Chemokine CCL2; Collagen Type I; Collagen Type III; Disease Models, Animal; Drug Therapy, Combination; Fibrosis; Kidney; Kidney Diseases; Macrophages; Male; Mice; Mice, Inbred C57BL; Pioglitazone; Plasminogen Activator Inhibitor 1; PPAR gamma; RNA, Messenger; Severity of Illness Index; Tetrazoles; Thiazolidinediones; Transforming Growth Factor beta; Ureteral Obstruction	2010
Pioglitazone inhibits TGFβ induced keratocyte transformation to myofibroblast and extracellular matrix production. Molecular biology reports, 2011, Volume: 38, Issue:7 Topics: Actin Cytoskeleton; Actins; Animals; Cell Differentiation; Cell Line, Transformed; Cell Proliferation; Collagen Type I; Corneal Keratocytes; Extracellular Matrix; Fibronectins; Humans; Myofibroblasts; Pioglitazone; PPAR gamma; Rabbits; RNA, Messenger; Stress Fibers; Thiazolidinediones; Transforming Growth Factor beta	2011
PPAR-gamma agonist ameliorates kidney and liver disease in an orthologous rat model of human autosomal recessive polycystic kidney disease. American journal of physiology. Renal physiology, 2011, Volume: 300, Issue:2 Topics: Animals; Blood Urea Nitrogen; Cell Proliferation; Disease Models, Animal; Disease Progression; Female; Ki-67 Antigen; Liver Cirrhosis; Liver Diseases; Male; Mitogen-Activated Protein Kinase Kinases; Pioglitazone; Polycystic Kidney, Autosomal Recessive; PPAR gamma; Rats; Rats, Sprague-Dawley; Thiazolidinediones; Transforming Growth Factor beta	2011
Peroxisome proliferator-activated receptor gamma ligands inhibit transforming growth factor-beta-induced, hyaluronan-dependent, T cell adhesion to orbital fibroblasts. The Journal of biological chemistry, 2011, May-27, Volume: 286, Issue:21 Topics: Cell Adhesion; Cells, Cultured; Fibroblasts; Fibrosis; Glucuronosyltransferase; Humans; Hyaluronan Synthases; Hyaluronic Acid; Hypoglycemic Agents; Inflammation; Ligands; Orbit; Orbital Diseases; Pioglitazone; PPAR gamma; RNA, Messenger; Rosiglitazone; T-Lymphocytes; Thiazolidinediones; Transforming Growth Factor beta	2011
Pioglitazone reduces peritoneal fibrosis via inhibition of TGF-β, MMP-2, and MMP-9 in a model of encapsulating peritoneal sclerosis. Renal failure, 2012, Volume: 34, Issue:1 Topics: Animals; Female; Matrix Metalloproteinase Inhibitors; Peritoneal Fibrosis; Pioglitazone; Rats; Rats, Wistar; Thiazolidinediones; Transforming Growth Factor beta	2012
Renoprotective effect of pioglitazone by the prevention of glomerular hyperfiltration through the possible restoration of altered macula densa signaling in rats with type 2 diabetic nephropathy. Nephron. Experimental nephrology, 2012, Volume: 122, Issue:3-4 Topics: Animals; Cyclooxygenase 2; Desmin; Diabetic Nephropathies; Juxtaglomerular Apparatus; Kidney Glomerulus; Male; Nitric Oxide Synthase Type I; Pioglitazone; Rats; Rats, Inbred OLETF; Signal Transduction; Thiazolidinediones; Transforming Growth Factor beta	2012
Inhibitory effects of peroxisome proliferator-activated receptor γ agonists on collagen IV production in podocytes. Molecular and cellular biochemistry, 2015, Volume: 405, Issue:1-2 Topics: Animals; Cells, Cultured; Collagen; Mice; Phosphorylation; Pioglitazone; Podocytes; PPAR gamma; Promoter Regions, Genetic; Rosiglitazone; Smad2 Protein; Smad3 Protein; Thiazolidinediones; Transforming Growth Factor beta; Up-Regulation	2015
Spontaneous Aortic Regurgitation and Valvular Cardiomyopathy in Mice. Arteriosclerosis, thrombosis, and vascular biology, 2015, Volume: 35, Issue:7 Topics: Actins; Animals; Aortic Valve; Aortic Valve Insufficiency; Calcinosis; Cell Death; Disease Progression; Fibrosis; Gene Expression; Heart Valve Diseases; Lipid Metabolism; Mice; Mice, Mutant Strains; Osteocalcin; Pioglitazone; Proteoglycans; Sp7 Transcription Factor; Systole; Thiazolidinediones; Transcription Factors; Transforming Growth Factor beta	2015
Pioglitazone attenuates hepatic inflammation and fibrosis in phosphatidylethanolamine N-methyltransferase-deficient mice. American journal of physiology. Gastrointestinal and liver physiology, 2016, 04-01, Volume: 310, Issue:7 Topics: Actins; Adipocytes, White; Adipose Tissue, White; Adiposity; Animals; Anti-Infective Agents; Cell Proliferation; Collagen Type I; Collagen Type I, alpha 1 Chain; Diet, High-Fat; Genetic Predisposition to Disease; Hepatitis; Insulin Resistance; Liver; Liver Cirrhosis, Experimental; Mice, Inbred C57BL; Mice, Knockout; Non-alcoholic Fatty Liver Disease; Obesity; Oxidative Stress; Phenotype; Phosphatidylethanolamine N-Methyltransferase; Pioglitazone; PPAR gamma; Signal Transduction; Thiazolidinediones; Time Factors; Tissue Inhibitor of Metalloproteinase-1; Transforming Growth Factor beta	2016
Peroxisome proliferator-activated receptor-γ agonist pioglitazone fails to attenuate renal fibrosis caused by unilateral ureteral obstruction in mice. Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban, 2016, Volume: 36, Issue:1 Topics: Animals; Chemokine CCL2; Fibrosis; Kidney; Kidney Diseases; Male; Mice; Mice, Inbred C57BL; Pioglitazone; PPAR gamma; T-Lymphocyte Subsets; Thiazolidinediones; Transforming Growth Factor beta; Urethral Obstruction	2016
Celecoxib and Pioglitazone as Potential Therapeutics for Regulating TGF-β-Induced Hyaluronan in Dysthyroid Myopathy. Investigative ophthalmology & visual science, 2016, Apr-01, Volume: 57, Issue:4 Topics: Adult; Blotting, Western; Case-Control Studies; Celecoxib; Cells, Cultured; Cyclooxygenase 2 Inhibitors; Enzyme-Linked Immunosorbent Assay; Female; Graves Ophthalmopathy; Humans; Hyaluronic Acid; Male; Middle Aged; Myoblasts; Oculomotor Muscles; Pioglitazone; PPAR gamma; Real-Time Polymerase Chain Reaction; Thiazolidinediones; Transforming Growth Factor beta	2016
Pioglitazone Alleviates Cardiac Fibrosis and Inhibits Endothelial to Mesenchymal Transition Induced by Pressure Overload. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 2018, Volume: 45, Issue:1 Topics: Anilides; Animals; Cardiomegaly; Cell Differentiation; Echocardiography; Fibrosis; Hemodynamics; Human Umbilical Vein Endothelial Cells; Humans; Male; Mice; Mice, Inbred C57BL; Myocardium; Pioglitazone; PPAR gamma; Pressure; Signal Transduction; Smad Proteins; Thiazolidinediones; Transforming Growth Factor beta; Vimentin	2018
Role of Wnt4/β-catenin, Ang II/TGFβ, ACE2, NF-κB, and IL-18 in attenuating renal ischemia/reperfusion-induced injury in rats treated with Vit D and pioglitazone. European journal of pharmacology, 2018, Jul-15, Volume: 831 Topics: Angiotensin II; Angiotensin-Converting Enzyme 2; Animals; beta Catenin; Cytoprotection; Disease Models, Animal; Hydroxycholecalciferols; Intercellular Adhesion Molecule-1; Interleukin-18; Kidney; Kidney Diseases; Male; Neutrophil Infiltration; NF-kappa B; Peptidyl-Dipeptidase A; Peroxidase; Pioglitazone; Rats, Sprague-Dawley; Reperfusion Injury; Thiazolidinediones; Time Factors; Transforming Growth Factor beta; Wnt Signaling Pathway; Wnt4 Protein	2018
Nanoparticle-mediated local delivery of pioglitazone attenuates bleomycin-induced skin fibrosis. Journal of dermatological science, 2019, Volume: 93, Issue:1 Topics: Animals; Bleomycin; Cell Differentiation; Delayed-Action Preparations; Disease Models, Animal; Drug Carriers; Fibroblasts; Fibrosis; Humans; Injections, Subcutaneous; Mice; Mice, Inbred BALB C; Nanoparticles; Pioglitazone; Polylactic Acid-Polyglycolic Acid Copolymer; PPAR gamma; Scleroderma, Localized; Skin; Transforming Growth Factor beta; Treatment Outcome	2019
The PPARγ agonist pioglitazone prevents TGF-β induced renal fibrosis by repressing EGR-1 and STAT3. BMC nephrology, 2019, 07-05, Volume: 20, Issue:1 Topics: Animals; Early Growth Response Protein 1; Fibrosis; Kidney Diseases; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Pioglitazone; PPAR gamma; STAT3 Transcription Factor; Transforming Growth Factor beta	2019
Carvacrol and PPARγ agonist, pioglitazone, affects inhaled paraquat-induced lung injury in rats. Scientific reports, 2021, 04-14, Volume: 11, Issue:1 Topics: Animals; Case-Control Studies; Cymenes; Dexamethasone; Disease Models, Animal; Drug Synergism; Gene Expression Regulation; Interleukin-6; Lung Injury; Male; Oxidative Stress; Paraquat; Pioglitazone; Rats; Rats, Wistar; Transforming Growth Factor beta; Treatment Outcome	2021
Combination of pioglitazone, a PPARγ agonist, and synthetic surfactant B-YL prevents hyperoxia-induced lung injury in adult mice lung explants. Pulmonary pharmacology & therapeutics, 2023, Volume: 80 Topics: Animals; Hyperoxia; Lung; Lung Injury; Mice; Pioglitazone; PPAR gamma; PPAR-gamma Agonists; Surface-Active Agents; Transforming Growth Factor beta	2023
A gut microbial metabolite of linoleic acid ameliorates liver fibrosis by inhibiting TGF-β signaling in hepatic stellate cells. Scientific reports, 2023, 11-03, Volume: 13, Issue:1 Topics: Animals; Diet, High-Fat; Fibrosis; Gastrointestinal Microbiome; Hepatic Stellate Cells; Humans; Linoleic Acid; Liver; Liver Cirrhosis; Mice; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease; Pioglitazone; Transforming Growth Factor beta	2023