Page last updated: 2024-08-16

pioglitazone and losartan

pioglitazone has been researched along with losartan in 19 studies

Research

Studies (19)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's3 (15.79)29.6817
2010's13 (68.42)24.3611
2020's3 (15.79)2.80

Authors

AuthorsStudies
Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ1
Ekins, S; Williams, AJ; Xu, JJ1
Ambroso, JL; Ayrton, AD; Baines, IA; Bloomer, JC; Chen, L; Clarke, SE; Ellens, HM; Harrell, AW; Lovatt, CA; Reese, MJ; Sakatis, MZ; Taylor, MA; Yang, EY1
Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ1
Aleo, MD; Bonin, PD; Luo, Y; Potter, DM; Swiss, R; Will, Y1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K1
Gust, R; Obexer, P; Salcher, S; Schoepf, AM1
Norman, BH1
Boschmann, M; Engeli, S; Gorzelniak, K; Janke, J; Jordan, J; Luft, FC; Nystrom, FH; Sauma, L; Schupp, M; Sharma, AM1
Jin, HM; Pan, Y1
Carranza, A; Mayer, MA; Peredo, HA; Puyó, AM1
Alosh, M; Huque, MF1
Kong, X; Li, FX; Wu, HB; Zhang, DY1
El-Moselhy, MA; Heeba, GH; Mourad, AA; Taye, A1
Bagchi, D; Echard, B; Fu, J; Kaylor, M; Perricone, NV; Preuss, HG; Zhuang, C1
Kong, X; Li, FX; Su, Q; Wu, HB; Zhang, DY; Zhang, Y1
Kong, X; Li, XY; Ma, MZ; Qin, L; Su, Q; Wang, GD; Zhang, DY; Zhang, Y1
Fazio, S; Kon, V; Linton, MF; Narita, I; Yamamoto, S; Yancey, PG; Yang, H; Zhong, J; Zuo, Y1
Abuiessa, SA; El-Gowelli, HM; El-Gowilly, SM; El-Mas, MM; Helmy, MM1

Reviews

2 review(s) available for pioglitazone and losartan

ArticleYear
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
    Drug discovery today, 2016, Volume: 21, Issue:4

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk

2016
Drug Induced Liver Injury (DILI). Mechanisms and Medicinal Chemistry Avoidance/Mitigation Strategies.
    Journal of medicinal chemistry, 2020, 10-22, Volume: 63, Issue:20

    Topics: Animals; Cell Line; Cell Survival; Chemical and Drug Induced Liver Injury; Drug Discovery; Drug Evaluation, Preclinical; Hepatocytes; Humans; Liver; Mitochondria, Liver; Pharmaceutical Preparations; Risk Assessment; Tissue Distribution

2020

Trials

1 trial(s) available for pioglitazone and losartan

ArticleYear
Renoprotection provided by losartan in combination with pioglitazone is superior to renoprotection provided by losartan alone in patients with type 2 diabetic nephropathy.
    Kidney & blood pressure research, 2007, Volume: 30, Issue:4

    Topics: Adult; Aged; Aged, 80 and over; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Drug Therapy, Combination; Female; Humans; Kidney Failure, Chronic; Losartan; Male; Middle Aged; Pioglitazone; Thiazolidinediones

2007

Other Studies

16 other study(ies) available for pioglitazone and losartan

ArticleYear
Developing structure-activity relationships for the prediction of hepatotoxicity.
    Chemical research in toxicology, 2010, Jul-19, Volume: 23, Issue:7

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes

2010
A predictive ligand-based Bayesian model for human drug-induced liver injury.
    Drug metabolism and disposition: the biological fate of chemicals, 2010, Volume: 38, Issue:12

    Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands

2010
Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds.
    Chemical research in toxicology, 2012, Oct-15, Volume: 25, Issue:10

    Topics: Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Decision Trees; Drug Evaluation, Preclinical; Drug-Related Side Effects and Adverse Reactions; Glutathione; Humans; Liver; Pharmaceutical Preparations; Protein Binding

2012
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
    Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:12

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship

2012
Human drug-induced liver injury severity is highly associated with dual inhibition of liver mitochondrial function and bile salt export pump.
    Hepatology (Baltimore, Md.), 2014, Volume: 60, Issue:3

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Chemical and Drug Induced Liver Injury; Humans; Male; Mitochondria, Liver; Rats; Rats, Sprague-Dawley; Severity of Illness Index

2014
Identification and development of non-cytotoxic cell death modulators: Impact of sartans and derivatives on PPARγ activation and on growth of imatinib-resistant chronic myelogenous leukemia cells.
    European journal of medicinal chemistry, 2020, Jun-01, Volume: 195

    Topics: Animals; Cell Death; Cell Proliferation; Chlorocebus aethiops; COS Cells; Drug Design; Drug Resistance, Neoplasm; Humans; Imatinib Mesylate; K562 Cells; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; PPAR gamma; Structure-Activity Relationship; Telmisartan

2020
Angiotensin type 1 receptor antagonists induce human in-vitro adipogenesis through peroxisome proliferator-activated receptor-gamma activation.
    Journal of hypertension, 2006, Volume: 24, Issue:9

    Topics: Adipogenesis; Adiponectin; Adipose Tissue; Angiotensin II Type 1 Receptor Blockers; Benzimidazoles; Benzoates; Biphenyl Compounds; Humans; Irbesartan; Lipoprotein Lipase; Losartan; Luciferases; Male; Pioglitazone; PPAR gamma; Receptor, Angiotensin, Type 1; RNA, Messenger; Telmisartan; Tetrazoles; Thiazolidinediones

2006
Pioglitazone and losartan modify hemodynamic and metabolic parameters and vascular prostanoids in fructose-overloaded rats.
    Clinical and experimental hypertension (New York, N.Y. : 1993), 2008, Volume: 30, Issue:2

    Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Aorta; Blood Pressure; Blood Vessels; Dinoprostone; Drug Synergism; Epoprostenol; Fructose; Hemodynamics; In Vitro Techniques; Losartan; Male; Mesentery; Pioglitazone; PPAR gamma; Prostaglandins; Rats; Rats, Sprague-Dawley; Thiazolidinediones; Thromboxanes; Triglycerides

2008
A consistency-adjusted alpha-adaptive strategy for sequential testing.
    Statistics in medicine, 2010, Jul-10, Volume: 29, Issue:15

    Topics: Algorithms; Biostatistics; Captopril; Clinical Trials as Topic; Data Interpretation, Statistical; Diabetic Angiopathies; Endpoint Determination; Epidemiologic Research Design; Heart Failure; Humans; Losartan; Pioglitazone; Randomized Controlled Trials as Topic; Thiazolidinediones

2010
Losartan and pioglitazone ameliorate nephropathy in experimental metabolic syndrome rats.
    Biological & pharmaceutical bulletin, 2011, Volume: 34, Issue:5

    Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Base Sequence; Blotting, Western; DNA Primers; Enzyme-Linked Immunosorbent Assay; Hypoglycemic Agents; Kidney Diseases; Losartan; Male; Metabolic Syndrome; Pioglitazone; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; Thiazolidinediones

2011
Comparative study between atorvastatin and losartan on high fat diet-induced type 2 diabetes mellitus in rats.
    Fundamental & clinical pharmacology, 2013, Volume: 27, Issue:5

    Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Atorvastatin; Cholesterol, LDL; Diabetes Mellitus, Type 2; Diet, High-Fat; Drug Therapy, Combination; Heptanoic Acids; Hypercholesterolemia; Hyperglycemia; Hypoglycemic Agents; Hypolipidemic Agents; Insulin Resistance; Losartan; Male; Obesity; Pioglitazone; Pyrroles; Random Allocation; Rats; Rats, Sprague-Dawley; Thiazolidinediones; Tumor Necrosis Factor-alpha

2013
Fraction SX of maitake mushroom favorably influences blood glucose levels and blood pressure in streptozotocin-induced diabetic rats.
    Journal of medicinal food, 2012, Volume: 15, Issue:10

    Topics: Animals; Blood Glucose; Blood Pressure; Body Weight; Diabetes Mellitus, Experimental; Grifola; Hypoglycemic Agents; Insulin; Insulin Resistance; Losartan; Male; Pioglitazone; Rats; Rats, Sprague-Dawley; Renin-Angiotensin System; Thiazolidinediones

2012
Combination therapy with losartan and pioglitazone additively reduces renal oxidative and nitrative stress induced by chronic high fat, sucrose, and sodium intake.
    Oxidative medicine and cellular longevity, 2012, Volume: 2012

    Topics: Animals; Body Weight; Diet, High-Fat; Dietary Sucrose; Drug Synergism; Drug Therapy, Combination; Gene Expression Regulation, Enzymologic; Immunohistochemistry; Kidney; Losartan; Male; Malondialdehyde; NADPH Oxidases; Nitrosation; Oxidation-Reduction; Oxidative Stress; Pioglitazone; Rats; Rats, Sprague-Dawley; RNA, Messenger; Sodium, Dietary; Superoxide Dismutase; Thiazolidinediones; Tyrosine

2012
Pioglitazone enhances the blood pressure-lowering effect of losartan via synergistic attenuation of angiotensin II-induced vasoconstriction.
    Journal of the renin-angiotensin-aldosterone system : JRAAS, 2014, Volume: 15, Issue:3

    Topics: Acetylcholine; Angiotensin II; Animals; Aorta; Blood Pressure; Drug Synergism; Endothelium, Vascular; Losartan; Male; NADPH Oxidases; Nitric Oxide Synthase Type III; Nitroprusside; Phenylephrine; Pioglitazone; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1; Systole; Thiazolidinediones; Tyrosine; Vasoconstriction; Vasodilation

2014
Atherosclerosis following renal injury is ameliorated by pioglitazone and losartan via macrophage phenotype.
    Atherosclerosis, 2015, Volume: 242, Issue:1

    Topics: Angiotensin Receptor Antagonists; Animals; Aortic Diseases; Apolipoproteins E; Apoptosis; Atherosclerosis; Cell Line; Cytokines; Disease Models, Animal; Drug Evaluation, Preclinical; Drug Synergism; Drug Therapy, Combination; Female; Hyperlipidemias; Inflammation; Losartan; Macrophages; Mice; Mice, Inbred C57BL; Mice, Knockout; Nephrectomy; Phenotype; Pioglitazone; PPAR gamma; Renal Insufficiency, Chronic; Renin-Angiotensin System; Thiazolidinediones

2015
Dysregulated ACE/Ang II/Ang1-7 signaling provokes cardiovascular and inflammatory sequelae of endotoxemia in weaning preeclamptic rats.
    European journal of pharmacology, 2022, Dec-05, Volume: 936

    Topics: Angiotensin II; Animals; Endotoxemia; Female; Humans; Losartan; Peptidyl-Dipeptidase A; Pioglitazone; Pre-Eclampsia; Pregnancy; Rats; Renin-Angiotensin System; Weaning

2022