pioglitazone has been researched along with gw9662 in 86 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 23 (26.74) | 29.6817 |
| 2010's | 55 (63.95) | 24.3611 |
| 2020's | 8 (9.30) | 2.80 |
| Authors | Studies |
|---|---|
| Baker, G; Davies, S; Evans, M; Heufelder, A; Joba, W; Ludgate, M; Starkey, K | 1 |
| Chen, J; Chen, Q; Jiang, H; Shen, J; Shen, X; Sun, T | 1 |
| Camacho, IE; De Strooper, B; Dominguez, D; Merchiers, P; Serneels, L; Spittaels, K | 1 |
| Bouaboula, M; Casellas, P; Fajas, L; Hilairet, S; Le Fur, G; Marchand, J | 1 |
| Horiuchi, A; Kagechika, H; Kamisaka, Y; Nakatsu, M; Okuma, E; Saeki, K; Uemura, I; Yasuda, K; Yasugi, E; Yuo, A | 1 |
| Bodles, AM; Kern, PA; McGehee, RE; Peterson, CA; Phanavanh, B; Rasouli, N; Varma, V; Wabitsch, M; Yao-Borengasser, A | 1 |
| Jin, SM; Kim, SR; Kim, UH; Lee, KS; Lee, MK; Lee, YC; Min, KH; Park, HS; Park, SJ | 1 |
| Ge, H; Guo, BS; He, B; Wang, BY; Wang, CQ; Zhang, JF | 1 |
| Fukazawa, Y; Kiguchi, N; Kishioka, S; Maeda, T; Ozaki, M; Yamamoto, A | 1 |
| Ge, H; Guo, BS; He, B; He, Q; Wang, BY; Wang, CQ; Zhang, JF | 1 |
| Makino, H; Ogawa, D; Ohga, S; Okada, S; Shikata, K; Shikata, Y; Usui, H; Wada, J; Yozai, K | 1 |
| Bowen, KK; Feinstein, DL; Kapadia, R; Liang, J; Satriotomo, I; Tureyen, K; Vemuganti, R | 1 |
| Blumenthal, RD; Burton, JD; Castillo, ME; Goldenberg, DM | 1 |
| Fan, FY; Li, S; Sun, PY; Yan, H; Zhu, JH; Zhu, WG | 1 |
| Hara, Y; Mukohda, M; Nomura, H; Okada, M; Yamawaki, H | 1 |
| Kiguchi, N; Kishioka, S; Kobayashi, Y; Maeda, T; Ozaki, M | 1 |
| Atkins, KB; Brosius, FC; Irey, B; Xiang, N | 1 |
| Fujiwara, H; Fujiwara, T; Iwasa, M; Kawamura, I; Kobayashi, H; Minatoguchi, S; Nagashima, K; Narentuoya, B; Nishigaki, K; Sumi, S; Takemura, G; Ushikoshi, H; Yamaki, T; Yasuda, S | 1 |
| Han, YJ; Jin, Z; Li, CF; Li, J; Lv, YM; Zhang, YP | 1 |
| Bernardo, A; Bianchi, D; Magnaghi, V; Minghetti, L | 1 |
| Arena, V; Biscetti, F; De Angelis, G; Flex, A; Ghirlanda, G; Iuliano, L; Pecorini, G; Rizzo, P; Stigliano, E; Straface, G | 1 |
| Karpushev, AV; Levchenko, V; Pavlov, TS; Staruschenko, A; Vandewalle, A | 1 |
| Izawa, Y; Suzuki, N; Takahashi, S | 1 |
| Clerget-Froidevaux, MS; Decherf, S; Demeneix, B; Elgaaied, AB; Guissouma, H; Kouidhi, S; Seugnet, I | 1 |
| Cheng, C; He, X; Hu, L; Ji, H; Li, X; Liu, F; Qian, J; Shen, A; Yan, M; Zhang, F; Zhang, L | 1 |
| Lai, CC; Yang, CR | 1 |
| Hu, Z; Lin, Y; Perez-Polo, JR; Ye, Y; Zhang, C | 1 |
| Abd-Elrahman, KS; Abdel-Galil, AG; El-Gowelli, HM; El-Mas, MM; Saad, EI | 1 |
| Braconi, S; Cannella, N; Ciccocioppo, R; Cippitelli, A; Demopulos, G; Gaitanaris, G; Heilig, M; Kallupi, M; Massi, M; Ruggeri, B; Somaini, L; Stopponi, S | 1 |
| Ma, Z; Wang, W; Zhu, B; Zhu, Z | 1 |
| Bothwell, AL; Choi, JM; Kawikova, I; Kulkarni, S; Lorber, MI; Manes, TD; Pober, JS; Qin, L; Rodriguez, FC; Tellides, G; Tobiasova, Z; Yi, T; Zhang, L | 1 |
| Dehpour, AR; Fard, YY; Gharedaghi, MH; Javadi-Paydar, M; Sadaghiani, MS | 1 |
| Bersinger, NA; McKinnon, B; Mueller, MD | 1 |
| Adabi Mohazab, R; Dehpour, AR; Delfan, B; Javadi-Paydar, M | 1 |
| Hirata, Y; Hishikari, K; Isobe, M; Masumura, M; Nagai, R; Nagashima, A; Ogawa, M; Shimizu, T; Suzuki, J; Takayama, K; Watanabe, R | 1 |
| Chen, T; Cheng, H; Crawford, BH; Ding, G; Jin, X; Saafir, TB; Wagner, MB; Yuan, Z | 1 |
| Becher, UM; Fung, S; Müller, CF; Nickenig, G; Panek, D; Tiyerili, V | 1 |
| Chen, G; Liu, J; Wan, H; Yuan, Y | 1 |
| Egashira, K; Kim-Mitsuyama, S; Matoba, T; Nagahama, R; Nakano, K; Sunagawa, K | 1 |
| Bucolo, C; Drago, F; Salomone, S; Siarkos, I; Sinagra, T; Tamburella, A; Urso, V | 1 |
| Cao, ZL; Li, Y; Li, ZB; Shen, L; Wang, H; Ye, P; Zhu, QW | 1 |
| Donahue, RR; Griggs, RB; Morgenweck, J; Taylor, BK; Zadina, JE | 1 |
| Li, Y; Li, ZB; Wang, H; Wang, L; Ye, P | 1 |
| Chen, C; Gu, H; Hu, N; Ji, M; Xu, Y; Zhang, J; Zhu, J | 1 |
| Khoramjouy, M; Malekinejad, H; Mehrabi, M; Rezaei-Golmisheh, A | 1 |
| Azarfardian, A; Charkhpour, M; Ghanbarzadeh, S; Ghavimi, H; Hassanzadeh, K; Maleki-Dizaji, N | 1 |
| Emoto, M; Fukumoto, S; Imanishi, Y; Inaba, M; Ishimura, E; Koyama, H; Mori, K; Morioka, T; Motoyama, K; Nakatani, S; Ochi, A | 1 |
| Shen, L; Wang, H; Ye, P | 1 |
| Azarfardian, A; Charkhpour, M; Ghasami, S; Ghavimi, H; Hassanzadeh, K; Maleki-Dizaji, N; Zolali, E | 1 |
| Kakuta, H; Sugimoto, Y; Yamamoto, A | 1 |
| Bollag, WB; Chen, X; Choudhary, V; Olala, L; Pan, ZQ; Seremwe, M; Tsai, YY; Xie, D | 1 |
| Ciccocioppo, R; de Guglielmo, G; Demopulos, G; Gaitanaris, G; Kallupi, M; Scuppa, G; Stopponi, S | 1 |
| Hosaka, T; Inukai, K; Ishida, H; Katsuta, H; Kitahara, A; Moriya, R; Nishida, S; Onuma, H; Sumitani, Y; Takahashi, K; Tanaka, T | 1 |
| Ciccocioppo, R; Cippitelli, A; Damadzic, R; de Guglielmo, G; De Luca, MA; Demopulos, G; Gaitanaris, G; Giordano, A; Heilig, M; Kallupi, M; Li, HW; Melis, M; Niswender, K; Senzacqua, M; Somaini, L; Tapocik, J | 1 |
| Cheong, SJ; Jeong, HJ; Kim, EM; Lee, CM; Lim, ST; Sohn, MH | 1 |
| Dehpour, A; Jahanabadi, S; Javadi, S; Khoshnoodi, M; Mehr, SE; Shafaroodi, H; Shahsavarian, A; Shamsaee, J | 1 |
| Aghaei, HN; Dehpour, AR; Ebrahimi, A; Gholizadeh, R; Gooshe, M; Mousavizadeh, K; Payandemehr, B; Rahimian, R; Varastehmoradi, B | 1 |
| Di, BB; Li, HW; Li, WP; Shen, XH; Sun, ZJ; Wu, X | 1 |
| Arami, S; Charkhpour, M; Ghasemi, S; Ghavimi, H; Hamishehkar, H; Hassanzadeh, K; Mesgari, M | 1 |
| Chalouhi, N; Chu, Y; Faraci, FM; Gu, H; Hasan, DM; Heistad, DD; Sigmund, CD; Starke, RM; Wilson, K | 1 |
| Furukawa, H; Hashimoto, T; Kitazato, KT; Korai, M; Kuwabara, A; Lawton, MT; Nagahiro, S; Shikata, F; Shimada, K; Tada, Y; Wada, K; Wei, Y | 1 |
| Amiridis, S; Bjorksten, AR; Ching, J; Kaye, AH; Kountouri, N; Luwor, RB; Morokoff, AP; O'Brien, TJ; Paradiso, L; Stylli, SS; Zheng, T | 1 |
| Chen, W; Fu, C; Lu, Y; Xiao, J; Yan, Z; Ye, Z; Zhang, X; Zhang, Z | 1 |
| Beltz, TG; Felder, RB; Guo, F; Johnson, AK; Wei, SG; Xue, BJ; Yu, Y; Zhang, ZH | 1 |
| Chen, C; Lou, XL; Xu, P | 1 |
| Matthews, SA; Samson, KK; Simeone, KA; Simeone, TA | 1 |
| Barbier, E; Ciccocioppo, R; Domi, E; Hansson, AC; Heilig, M; Soverchia, L; Spanagel, R; Ubaldi, M; Uhrig, S | 1 |
| Cunningham, KA; Denner, L; Dineley, KT; Fox, RG; Lane, SD; Miller, WR; Stutz, SJ | 1 |
| An, L; Li, F; Qi, B; Yuan, H; Zhang, Z; Zhao, H | 1 |
| Ghorbanzadeh, B; Mansouri, MT; Naghizadeh, B; Pashmforoush, M; Rajabi, H | 1 |
| Danaher, RJ; Lyons, DN; Miller, CS; Westlund, KN; Zhang, L | 1 |
| Fang, L; Li, J; Liao, L; Rao, CL; Xie, P; Yang, CC; Yang, DY; Zeng, L; Zhang, XD; Zhang, ZW; Zhao, LB; Zhou, CJ | 1 |
| Deng, W; Li, LL; Ma, ZG; Tang, QZ; Wei, WY; Xu, M; Yuan, YP; Zhang, N | 1 |
| Chen, Z; Hu, Z; Li, J; Liao, L; Qin, Y; Sun, L; Xie, P; Xu, B; Yang, C; Zhang, X; Zhou, C; Zhu, D | 1 |
| Hara, M; Ikeda, H; Iso-O, N; Kurano, M; Tsukamoto, K; Yatomi, Y | 1 |
| Alaiyed, S; Elkahloun, AG; Rodriguez, Y; Saavedra, JM; Wenzel, E | 1 |
| Chen, W; Fan, J; Gao, Z; Wang, H; Wu, H; Yu, X; Zhang, G | 1 |
| Atkins, A; Candeletti, S; Caputi, FF; Ciccocioppo, R; Demopulos, G; Domi, A; Domi, E; Gaitanaris, G; Heilig, M; Romualdi, P; Scuppa, G; Ubaldi, M | 1 |
| Gao, S; Hua, B; Li, H; Li, W; Liu, H; Liu, Q | 1 |
| Ciccocioppo, R; Demopulos, G; Domi, A; Domi, E; Gaitanaris, G; Somaini, L; Ubaldi, M | 1 |
| Abd El Fattah, MA; Abdelhamid, YA; Badary, OA; Elyamany, MF; Heikal, OA | 1 |
| Guo, P; Hu, S; Lu, Q; Ren, Z; Wang, X; Wu, Q; Zhu, X | 1 |
| Ching, J; Clancy, H; Lang, B; McCaig, CD; Pruski, M | 1 |
| Buijsers, B; de Graaf, M; Garsen, M; Gockeln, L; Hillebrands, JL; Kamps, JAAM; Krenning, G; Lamb, HJ; Maciej-Hulme, ML; Nijenhuis, T; Rabelink, TJ; Sol, M; Sonneveld, R; van den Born, J; van der Meer, RW; van der Vlag, J; van Kuppevelt, TH; van Raalte, DH | 1 |
| Astolfi, A; Ciavarella, C; Costa, A; Fornasiero, EF; Gargiulo, M; Lisi, AP; Mauro, R; Motta, I; Palumbo, T; Pasquinelli, G; Valente, S; Vasuri, F; Versura, P | 1 |
| de la Torre, R; Gallego-Landin, I; Garcia-Baos, A; Pastor, A; Sanz, F; Valverde, O | 1 |
86 other study(ies) available for pioglitazone and gw9662
| Article | Year |
|---|---|
Peroxisome proliferator-activated receptor-gamma in thyroid eye disease: contraindication for thiazolidinedione use?
Topics: Adipocytes; Adipose Tissue; Anilides; Cell Differentiation; Cells, Cultured; Contraindications; Graves Disease; Humans; Hypoglycemic Agents; Magnetic Resonance Imaging; Male; Middle Aged; Pioglitazone; Receptors, Cytoplasmic and Nuclear; RNA, Messenger; Stem Cells; Thiazoles; Thiazolidinediones; Transcription Factors | 2003 |
A yeast two-hybrid technology-based system for the discovery of PPARgamma agonist and antagonist.
Topics: alpha-Galactosidase; Anilides; Cells, Cultured; Chromans; CREB-Binding Protein; Drug Evaluation, Preclinical; Genes, Reporter; Indomethacin; Ligands; Nuclear Proteins; Oxazoles; Pioglitazone; PPAR gamma; Prostaglandin D2; Protein Binding; Rosiglitazone; Thiazolidinediones; Trans-Activators; Troglitazone; Two-Hybrid System Techniques; Tyrosine; Yeasts | 2004 |
Peroxisome-proliferator-activated receptor gamma induces a clearance mechanism for the amyloid-beta peptide.
Topics: Amyloid beta-Peptides; Amyloid Precursor Protein Secretases; Anilides; Animals; Aspartic Acid Endopeptidases; Cell Line; Cell Line, Tumor; Cells, Cultured; Cerebral Cortex; Chromans; Culture Media, Conditioned; Endopeptidases; Humans; Kidney; Mice; Neuroblastoma; Neuroglia; Neurons; Peptide Fragments; Pioglitazone; PPAR gamma; Protein Processing, Post-Translational; Receptor, Notch1; Receptors, Cell Surface; Recombinant Fusion Proteins; Retinoid X Receptors; Rosiglitazone; Thiazolidinediones; Transcription Factors; Tretinoin; Troglitazone | 2004 |
Anandamide induced PPARgamma transcriptional activation and 3T3-L1 preadipocyte differentiation.
Topics: 3T3-L1 Cells; Adipocytes; Adiponectin; Anilides; Animals; Arachidonic Acids; Binding Sites; Binding, Competitive; Blotting, Western; Cannabinoid Receptor Modulators; Carrier Proteins; CCAAT-Enhancer-Binding Protein-alpha; Cell Differentiation; Cell Line; Chlorocebus aethiops; Chromans; COS Cells; Dose-Response Relationship, Drug; Endocannabinoids; Fibroblasts; Gene Expression; HeLa Cells; Humans; Intercellular Signaling Peptides and Proteins; Luciferases; Mice; Perilipin-1; Phosphoproteins; Pioglitazone; Plasmids; Polyunsaturated Alkamides; PPAR gamma; Recombinant Fusion Proteins; Reverse Transcriptase Polymerase Chain Reaction; Thiazolidinediones; Transcriptional Activation; Transfection; Troglitazone | 2005 |
Peroxisome proliferator-activated receptor gamma ligands stimulate myeloid differentiation and lipogenensis in human leukemia NB4 cells.
Topics: Adipocytes; Anilides; Benzoates; Biphenyl Compounds; Cell Differentiation; Cell Line, Tumor; Cell Proliferation; Fatty Acid-Binding Proteins; Humans; Ligands; Lipids; Myeloid Cells; Pioglitazone; PPAR gamma; Prostaglandin D2; Thiazolidinediones; Tretinoin; Triglycerides; Tumor Cells, Cultured; Up-Regulation | 2006 |
Pioglitazone induces apoptosis of macrophages in human adipose tissue.
Topics: Adipocytes; Adipose Tissue; Anilides; Antigens, CD; Antigens, Differentiation, Myelomonocytic; Apoptosis; Caspase 3; Caspase 9; Caspases; CD36 Antigens; Cell Differentiation; Cell Line; Cells, Cultured; Dose-Response Relationship, Drug; Humans; Hypoglycemic Agents; Immunohistochemistry; In Situ Nick-End Labeling; Macrophages; Pioglitazone; PPAR gamma; Thiazolidinediones | 2006 |
Peroxisome proliferator activated receptor-gamma modulates reactive oxygen species generation and activation of nuclear factor-kappaB and hypoxia-inducible factor 1alpha in allergic airway disease of mice.
Topics: Anilides; Animals; Asthma; Chemokine CCL5; Female; Hypoxia-Inducible Factor 1, alpha Subunit; Intercellular Adhesion Molecule-1; Mice; Mice, Inbred C57BL; NF-kappa B; Pioglitazone; PPAR gamma; Reactive Oxygen Species; Rosiglitazone; Thiazolidinediones; Vascular Cell Adhesion Molecule-1 | 2006 |
[Resveratrol inhibits expression of EMMPRIN from macrophages].
Topics: Anilides; Antineoplastic Agents, Phytogenic; Basigin; Blotting, Western; Breast Neoplasms; Cell Differentiation; Cell Line; Cell Line, Tumor; Coculture Techniques; Dose-Response Relationship, Drug; Female; Humans; Luciferases; Macrophages; Matrix Metalloproteinase 9; Monocytes; Pioglitazone; PPAR gamma; Recombinant Fusion Proteins; Resveratrol; Stilbenes; Thiazolidinediones; U937 Cells | 2006 |
Peroxisome proliferator-activated receptor gamma activation relieves expression of behavioral sensitization to methamphetamine in mice.
Topics: Amphetamine-Related Disorders; Anilides; Animals; Behavior, Animal; Brain; Brain Chemistry; Cell Nucleus; Disease Models, Animal; Dopamine Uptake Inhibitors; Electrophoretic Mobility Shift Assay; Encephalitis; Hypoglycemic Agents; Male; Methamphetamine; Mice; Mice, Inbred ICR; Motor Activity; Nucleus Accumbens; Pioglitazone; PPAR gamma; Psychoses, Substance-Induced; Retinoid X Receptors; Reward; Thiazolidinediones | 2007 |
Resveratrol inhibits macrophage expression of EMMPRIN by activating PPARgamma.
Topics: Anilides; Anti-Inflammatory Agents, Non-Steroidal; Basigin; Cell Differentiation; Dose-Response Relationship, Drug; Gene Expression Regulation; Humans; I-kappa B Proteins; Macrophages; Matrix Metalloproteinase 9; Monocytes; NF-kappa B; Phosphorylation; Pioglitazone; PPAR gamma; Promoter Regions, Genetic; Resveratrol; Stilbenes; Tetradecanoylphorbol Acetate; Thiazolidinediones; Time Factors; Transfection; Tumor Necrosis Factor-alpha; U937 Cells | 2007 |
Thiazolidinedione ameliorates renal injury in experimental diabetic rats through anti-inflammatory effects mediated by inhibition of NF-kappaB activation.
Topics: Anilides; Animals; Anti-Inflammatory Agents; Cells, Cultured; Collagen Type IV; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Humans; Intercellular Adhesion Molecule-1; Kidney Glomerulus; Macrophage Activation; Male; NF-kappa B; Pioglitazone; PPAR gamma; Pyrrolidines; Rats; Rats, Sprague-Dawley; Thiazolidinediones; Thiocarbamates; Transforming Growth Factor beta | 2007 |
Peroxisome proliferator-activated receptor-gamma agonists induce neuroprotection following transient focal ischemia in normotensive, normoglycemic as well as hypertensive and type-2 diabetic rodents.
Topics: Anilides; Animals; Cerebral Infarction; Chemotaxis, Leukocyte; Cytokines; Diabetes Mellitus, Type 2; Disease Models, Animal; Encephalitis; Hypertension; Intercellular Adhesion Molecule-1; Ischemic Attack, Transient; Mice; Mice, Inbred C57BL; Mice, Mutant Strains; Neuroprotective Agents; Pioglitazone; PPAR gamma; Rats; Rats, Inbred SHR; Rats, Sprague-Dawley; Rosiglitazone; Superoxide Dismutase; Superoxide Dismutase-1; Suppressor of Cytokine Signaling 3 Protein; Suppressor of Cytokine Signaling Proteins; Thiazolidinediones | 2007 |
Peroxisome proliferator-activated receptor-gamma antagonists exhibit potent antiproliferative effects versus many hematopoietic and epithelial cancer cell lines.
Topics: Anilides; Antineoplastic Agents; Apoptosis; Benzamides; Carcinoma; Caspase Inhibitors; Caspases; Cell Line, Tumor; Cell Proliferation; Hematologic Neoplasms; Humans; Indicators and Reagents; Interleukin-6; Multiple Myeloma; Pioglitazone; PPAR gamma; Pyridines; Thiazolidinediones | 2007 |
[Pioglitazone inhibits dendritic cell adhesion and transmigration through down-regulation of dendritic cell-specific intercellular adhesion molecule-3 grabbing nonintegrin].
Topics: Anilides; Blotting, Western; Cell Adhesion; Cell Adhesion Molecules; Cell Line; Cell Movement; Cells, Cultured; Coculture Techniques; Dendritic Cells; Down-Regulation; Endothelial Cells; Humans; Lectins, C-Type; Microscopy, Confocal; Pioglitazone; Receptors, Cell Surface; Thiazolidinediones | 2008 |
Mechanisms underlying pioglitazone-mediated relaxation in isolated blood vessel.
Topics: Anilides; Animals; Aorta, Thoracic; Dose-Response Relationship, Drug; Endothelium, Vascular; In Vitro Techniques; Male; Muscle, Smooth, Vascular; Nitric Oxide; Norepinephrine; Pioglitazone; Potassium; Potassium Channels, Inwardly Rectifying; Potassium Channels, Voltage-Gated; PPAR gamma; Rats; Rats, Wistar; Thiazolidinediones; Vasoconstrictor Agents; Vasodilation; Vasodilator Agents | 2008 |
Pioglitazone attenuates tactile allodynia and thermal hyperalgesia in mice subjected to peripheral nerve injury.
Topics: Adipocytes; Analgesics; Anilides; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Ganglia, Spinal; Hot Temperature; Hyperalgesia; Inflammation Mediators; Interleukin-6; Ligation; Male; Mice; Mice, Inbred ICR; Pain Measurement; Pioglitazone; Posterior Horn Cells; PPAR gamma; Sciatic Nerve; Sciatic Neuropathy; Thiazolidinediones; Time Factors; Touch; Tumor Necrosis Factor-alpha | 2008 |
A rapid, PPAR-gamma-dependent effect of pioglitazone on the phosphorylation of MYPT.
Topics: Amides; Anilides; Animals; Cells, Cultured; Cyclic AMP-Dependent Protein Kinases; Cyclic GMP-Dependent Protein Kinases; Enzyme Inhibitors; Hypoglycemic Agents; Muscle, Smooth, Vascular; Myosin-Light-Chain Kinase; Phosphorylation; Pioglitazone; PPAR gamma; Protein Phosphatase 1; Pyridines; Rats; Rats, Sprague-Dawley; rho-Associated Kinases; Signal Transduction; Thiazolidinediones; Threonine | 2009 |
Antidiabetic drug pioglitazone protects the heart via activation of PPAR-gamma receptors, PI3-kinase, Akt, and eNOS pathway in a rabbit model of myocardial infarction.
Topics: Androstadienes; Anilides; Animals; Blood Glucose; Blotting, Western; Decanoic Acids; Disease Models, Animal; Enzyme Activation; Hemodynamics; Hydroxy Acids; Hypoglycemic Agents; Male; Myocardial Infarction; Myocardial Reperfusion Injury; Myocardium; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase Type III; Phosphatidylinositol 3-Kinases; Phosphorylation; Pioglitazone; Potassium Channel Blockers; Potassium Channels; PPAR gamma; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Rabbits; Thiazolidinediones; Time Factors; Ventricular Function, Left; Wortmannin | 2009 |
[Role of peroxisome proliferators-activated receptor-gamma in the chemical prevention therapy of sulindac for precancerous lesions of rats].
Topics: 1,2-Dimethylhydrazine; Anilides; Animals; Colorectal Neoplasms; Male; Pioglitazone; PPAR gamma; Precancerous Conditions; Rats; Rats, Sprague-Dawley; Sulindac; Thiazolidinediones | 2009 |
Peroxisome proliferator-activated receptor-gamma agonists promote differentiation and antioxidant defenses of oligodendrocyte progenitor cells.
Topics: Active Transport, Cell Nucleus; Anilides; Animals; Antioxidants; Catalase; Cell Differentiation; Cell Proliferation; Cells, Cultured; Dose-Response Relationship, Drug; Homeostasis; Oligodendroglia; Pioglitazone; PPAR gamma; Prostaglandin D2; Rats; Rats, Wistar; Stem Cells; Superoxide Dismutase; Thiazolidinediones | 2009 |
Pioglitazone enhances collateral blood flow in ischemic hindlimb of diabetic mice through an Akt-dependent VEGF-mediated mechanism, regardless of PPARgamma stimulation.
Topics: Anilides; Animals; Benzophenones; Blood Flow Velocity; Blood Glucose; Collateral Circulation; Diabetes Mellitus, Experimental; Hindlimb; Hypoglycemic Agents; Ischemia; Male; Mice; Mice, Inbred C57BL; Oncogene Protein v-akt; Pioglitazone; PPAR gamma; Signal Transduction; Thiazolidinediones; Tyrosine; Up-Regulation; Vascular Endothelial Growth Factor A | 2009 |
Peroxisome proliferator-activated receptor gamma antagonists decrease Na+ transport via the epithelial Na+ channel.
Topics: Anilides; Animals; Benzamides; Biological Transport; Cell Survival; CHO Cells; Chromans; Cricetinae; Cricetulus; Dose-Response Relationship, Drug; Epithelial Sodium Channels; Hypoglycemic Agents; Insulin; Membrane Potentials; Pioglitazone; PPAR gamma; Pyridines; Rosiglitazone; Sodium; Tetrazolium Salts; Thiazoles; Thiazolidinediones; Troglitazone | 2009 |
Pioglitazone enhances pyruvate and lactate oxidation in cultured neurons but not in cultured astroglia.
Topics: Analysis of Variance; Anilides; Animals; Astrocytes; Benzophenones; Cell Shape; Cells, Cultured; Cerebral Cortex; Dose-Response Relationship, Drug; Energy Metabolism; Hypoglycemic Agents; Lactic Acid; Neurons; Pioglitazone; PPAR gamma; Pyruvic Acid; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Thiazolidinediones; Tyrosine | 2009 |
Peroxisome proliferator-activated receptor-gamma (PPARgamma) modulates hypothalamic Trh regulation in vivo.
Topics: Anilides; Animals; Animals, Newborn; Gene Expression Regulation; Gene Knockdown Techniques; Glucose Transporter Type 4; Hypothalamus; Injections, Intraventricular; Mice; Pioglitazone; PPAR gamma; Promoter Regions, Genetic; Retinoid X Receptor alpha; Rosiglitazone; Thiazolidinediones; Thyroid Hormone Receptors beta; Thyrotropin-Releasing Hormone; Thyroxine; Transfection; Triiodothyronine | 2010 |
Peroxisome proliferator-activated receptor-gamma agonists suppress iNOS expression induced by LPS in rat primary Schwann cells.
Topics: Anilides; Animals; Anti-Inflammatory Agents; Blotting, Western; Cell Line; Down-Regulation; Enzyme Inhibitors; Fluorescent Antibody Technique; Lipopolysaccharides; Myeloid Differentiation Factor 88; Nitric Oxide Synthase Type II; p38 Mitogen-Activated Protein Kinases; Pioglitazone; PPAR gamma; Prostaglandin D2; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; Schwann Cells; Signal Transduction; Thiazolidinediones; Toll-Like Receptor 4 | 2010 |
Thiazolidinediones inhibit TNF-alpha-mediated osteoclast differentiation of RAW264.7 macrophages and mouse bone marrow cells through downregulation of NFATc1.
Topics: Anilides; Animals; Bone Marrow Cells; Cell Differentiation; Cell Line; Down-Regulation; Macrophages; Mice; NFATC Transcription Factors; Osteoclasts; Pioglitazone; PPAR gamma; Rosiglitazone; Thiazolidinediones; Tumor Necrosis Factor-alpha | 2010 |
Downregulation of microRNA-29 by antisense inhibitors and a PPAR-gamma agonist protects against myocardial ischaemia-reperfusion injury.
Topics: Anilides; Animals; Apoptosis; bcl-2-Associated X Protein; Blotting, Northern; Blotting, Western; Caspase 3; Cell Line; Cell Survival; Disease Models, Animal; Down-Regulation; Gene Expression Profiling; Mice; MicroRNAs; Myeloid Cell Leukemia Sequence 1 Protein; Myocardial Reperfusion Injury; Myocardium; Oligonucleotide Array Sequence Analysis; Oligonucleotides, Antisense; Phosphorylation; Pioglitazone; PPAR gamma; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-bcl-2; Rats; Rosiglitazone; Thiazolidinediones; Time Factors; Transfection | 2010 |
Role of PPAR gamma/nitric oxide synthase signaling in the cyclosporine-induced attenuation of endothelium-dependent renovascular vasodilation.
Topics: Anilides; Animals; Arginine; Carbachol; Cyclosporine; Endothelium-Dependent Relaxing Factors; Immunosuppressive Agents; In Vitro Techniques; Kidney; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Phenylephrine; Pioglitazone; PPAR gamma; Rats; Rats, Wistar; Signal Transduction; Thiazolidinediones; Vasoconstrictor Agents; Vasodilation | 2010 |
Activation of nuclear PPARγ receptors by the antidiabetic agent pioglitazone suppresses alcohol drinking and relapse to alcohol seeking.
Topics: Adrenergic alpha-2 Receptor Antagonists; Alcohol Drinking; Alcohols; Analysis of Variance; Anilides; Animals; Behavior, Animal; Blood Glucose; Conditioning, Operant; Cues; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Food Preferences; Gene Expression Regulation; Hypoglycemic Agents; Male; Pioglitazone; PPAR gamma; Rats; Rats, Sprague-Dawley; Rosiglitazone; Self Administration; Substance Withdrawal Syndrome; Thiazolidinediones; Yohimbine | 2011 |
Peroxisome proliferator-activated receptor-gamma agonist induces regulatory T cells in a murine model of allergic rhinitis.
Topics: Anilides; Animals; Female; Forkhead Transcription Factors; GATA3 Transcription Factor; Immunoglobulin E; Interferon-gamma; Interleukin-5; Mice; Mice, Inbred BALB C; Nasal Lavage Fluid; Nasal Mucosa; Ovalbumin; Pioglitazone; PPAR gamma; Rhinitis, Allergic, Perennial; T-Box Domain Proteins; T-Lymphocytes, Regulatory; Thiazolidinediones | 2011 |
Peroxisome proliferator-activated receptor-γ agonists prevent in vivo remodeling of human artery induced by alloreactive T cells.
Topics: Adoptive Transfer; Anilides; Animals; Arteries; Cell Movement; Cell Proliferation; Cytokines; Graft Rejection; Humans; Hypoglycemic Agents; Immunologic Memory; Isoantigens; Mice; Mice, SCID; Pioglitazone; PPAR gamma; Prostaglandin D2; Superantigens; T-Lymphocytes; Thiazolidinediones; Transplantation, Heterologous; Transplantation, Homologous | 2011 |
Antidepressant-like effect of pioglitazone in the forced swimming test in mice: the role of PPAR-gamma receptor and nitric oxide pathway.
Topics: Anilides; Animals; Antidepressive Agents; Arginine; Dose-Response Relationship, Drug; Enzyme Inhibitors; Guanidines; Hypoglycemic Agents; Male; Mice; Motor Activity; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase Type II; Pioglitazone; PPAR gamma; Swimming; Thiazolidinediones | 2011 |
Peroxisome proliferating activating receptor gamma-independent attenuation of interleukin 6 and interleukin 8 secretion from primary endometrial stromal cells by thiazolidinediones.
Topics: Anilides; Anti-Inflammatory Agents; Cells, Cultured; Dose-Response Relationship, Drug; Down-Regulation; Endometrium; Enzyme-Linked Immunosorbent Assay; Female; Humans; Inflammation Mediators; Interleukin-6; Interleukin-8; Pioglitazone; PPAR gamma; Real-Time Polymerase Chain Reaction; RNA, Messenger; Stromal Cells; Thiazolidinediones | 2012 |
Possible involvement of PPAR-gamma receptor and nitric oxide pathway in the anticonvulsant effect of acute pioglitazone on pentylenetetrazole-induced seizures in mice.
Topics: Anilides; Animals; Anticonvulsants; Arginine; Convulsants; Dose-Response Relationship, Drug; Enzyme Inhibitors; Guanidines; Male; Mice; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Pentylenetetrazole; Pioglitazone; PPAR gamma; Seizures; Signal Transduction; Thiazolidinediones | 2012 |
Different roles of PPAR-γ activity on physiological and pathological alteration after myocardial ischemia.
Topics: Amlodipine; Angiotensin II Type 1 Receptor Blockers; Anilides; Animals; Antihypertensive Agents; Benzimidazoles; Benzoates; Blood Pressure; Calcium Channel Blockers; Cells, Cultured; Disease Models, Animal; Drug Partial Agonism; Fibrosis; Hypertrophy, Left Ventricular; Male; Matrix Metalloproteinase 2; Myocardial Infarction; Myocardium; Pioglitazone; PPAR gamma; Rats; Rats, Sprague-Dawley; Stroke Volume; Telmisartan; Thiazolidinediones; Time Factors; Ventricular Function, Left; Ventricular Remodeling | 2012 |
Cardioprotection from oxidative stress in the newborn heart by activation of PPARγ is mediated by catalase.
Topics: Age Factors; Anilides; Animals; Animals, Newborn; Cardiotonic Agents; Catalase; Heart; Hydrogen Peroxide; L-Lactate Dehydrogenase; Organ Culture Techniques; Oxidative Stress; Pioglitazone; PPAR gamma; Rabbits; RNA, Messenger; Rosiglitazone; Thiazolidinediones; Up-Regulation; Ventricular Function, Left | 2012 |
Estrogen improves vascular function via peroxisome-proliferator-activated-receptor-γ.
Topics: Anilides; Animals; Apolipoproteins E; Blood Pressure; Blotting, Western; Body Weight; Estradiol; Estrogens; Female; Heart Rate; Immunohistochemistry; Mice; Pioglitazone; PPAR gamma; Reactive Oxygen Species; Real-Time Polymerase Chain Reaction; Superoxides; Thiazolidinediones | 2012 |
Pioglitazone, a PPAR-γ activator, attenuates the severity of cerulein-induced acute pancreatitis by modulating early growth response-1 transcription factor.
Topics: Acinar Cells; Acute Disease; Anilides; Animals; Cell Line, Tumor; Ceruletide; Chemokine CCL2; Chemokines; Disease Models, Animal; Early Growth Response Protein 1; Hypoglycemic Agents; Male; Pancreatitis; Pioglitazone; PPAR gamma; Rats; Rats, Sprague-Dawley; RNA, Messenger; Severity of Illness Index; Thiazolidinediones; Translational Research, Biomedical | 2012 |
Nanoparticle-mediated delivery of pioglitazone enhances therapeutic neovascularization in a murine model of hindlimb ischemia.
Topics: Anilides; Animals; Fibroblast Growth Factor 1; Hindlimb; Humans; Injections, Intramuscular; Ischemia; Lactic Acid; Mice; Mice, Knockout; Models, Animal; Nanoparticles; Neovascularization, Physiologic; Nitric Oxide Synthase Type III; Phosphorylation; Pioglitazone; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; PPAR gamma; Regional Blood Flow; Thiazolidinediones; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factor B | 2012 |
Reversible inhibition of vasoconstriction by thiazolidinediones related to PI3K/Akt inhibition in vascular smooth muscle cells.
Topics: Anilides; Animals; Chromans; Dose-Response Relationship, Drug; Enzyme Inhibitors; Femoral Artery; Male; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Nitroarginine; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Pioglitazone; PPAR gamma; Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley; Rosiglitazone; Thiazolidinediones; Troglitazone; Vasoconstriction | 2013 |
Pioglitazone attenuates myocardial ischemia-reperfusion injury via up-regulation of ERK and COX-2.
Topics: Anilides; Animals; Apoptosis; Blotting, Western; Cyclooxygenase 2; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Male; Myocardial Reperfusion Injury; Phosphorylation; Pioglitazone; Rats; Rats, Sprague-Dawley; Real-Time Polymerase Chain Reaction; Thiazolidinediones | 2012 |
PPARγ activation blocks development and reduces established neuropathic pain in rats.
Topics: Anilides; Animals; Ataxia; CD11b Antigen; Dose-Response Relationship, Drug; Drug Administration Schedule; Extracellular Signal-Regulated MAP Kinases; Glial Fibrillary Acidic Protein; Hyperalgesia; Male; Neuralgia; p38 Mitogen-Activated Protein Kinases; Pioglitazone; Posterior Horn Cells; PPAR gamma; Rats; Thiazolidinediones | 2013 |
[Effects of pioglitazone on TGFbeta1 expression in ischemia/reperfusion injury myocardium of rats].
Topics: Anilides; Animals; Apoptosis; Male; Myocardial Reperfusion Injury; Myocardium; Pioglitazone; PPAR gamma; Rats; Rats, Sprague-Dawley; Thiazolidinediones; Transforming Growth Factor beta1 | 2013 |
The role of peroxisome proliferator-activated receptor and effects of its agonist, pioglitazone, on a rat model of optic nerve crush: PPARγ in retinal neuroprotection.
Topics: Analysis of Variance; Anilides; Animals; Blotting, Western; Fluorescent Antibody Technique; Gene Expression Regulation; Immunohistochemistry; In Situ Nick-End Labeling; Neuroprotective Agents; Optic Nerve Injuries; Pioglitazone; PPAR gamma; Rats; Real-Time Polymerase Chain Reaction; Retinal Ganglion Cells; Thiazolidinediones | 2013 |
Antifibrotic effect of atorvastatin on paraquat-induced pulmonary fibrosis: role of PPARγ receptors.
Topics: Anilides; Animals; Atorvastatin; Body Weight; Heptanoic Acids; Herbicides; Hydroxyproline; Lung; Male; Organ Size; Paraquat; Pioglitazone; PPAR gamma; Protective Agents; Pulmonary Fibrosis; Pyrroles; Rats; Rats, Wistar; RNA, Messenger; Thiazolidinediones; Transforming Growth Factor beta1 | 2013 |
Acute administration of pioglitazone attenuates morphine withdrawal syndrome in rat: a novel role of pioglitazone.
Topics: Analgesics, Opioid; Anilides; Animals; Male; Morphine; Morphine Dependence; Naloxone; Pioglitazone; PPAR gamma; Rats; Rats, Wistar; Substance Withdrawal Syndrome; Thiazolidinediones | 2015 |
Direct inhibitory effects of pioglitazone on hepatic fetuin-A expression.
Topics: alpha-2-HS-Glycoprotein; Anilides; Animals; Cell Line, Tumor; Diabetes Mellitus, Type 2; Gene Expression; Hepatocytes; Humans; Hypoglycemic Agents; Insulin Resistance; Liver; Male; Metformin; Mice; Mice, Inbred C57BL; Pioglitazone; PPAR gamma; RNA, Messenger; Rosiglitazone; Thiazolidinediones | 2014 |
[Effects of pioglitazone on myocardial peroxisome proliferator-activated receptor gamma co-activator lα expression in rats with myocardial ischemia/reperfusion injury].
Topics: Anilides; Animals; Apoptosis; Male; Myocardial Reperfusion Injury; Myocardium; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; Pioglitazone; Rats; Rats, Sprague-Dawley; Thiazolidinediones; Transcription Factors | 2014 |
Pioglitazone prevents morphine antinociception tolerance and withdrawal symptoms in rats.
Topics: Analgesics, Opioid; Anilides; Animals; Behavior, Animal; Drug Tolerance; Male; Morphine; Motor Activity; Naloxone; Narcotic Antagonists; Pain; Pioglitazone; PPAR gamma; Rats, Wistar; Substance Withdrawal Syndrome; Thiazolidinediones | 2014 |
Involvement of glucocorticoid receptor activation on anti-inflammatory effect induced by peroxisome proliferator-activated receptor γ agonist in mice.
Topics: Anilides; Animals; Carrageenan; Dexamethasone; Edema; Female; Mice; Mice, Inbred ICR; Mifepristone; Models, Animal; Pioglitazone; PPAR gamma; Pyridinium Compounds; Receptors, Glucocorticoid; Retinoid X Receptors; Signal Transduction; Styrenes; Thiazolidinediones | 2014 |
The effect of pioglitazone on aldosterone and cortisol production in HAC15 human adrenocortical carcinoma cells.
Topics: Adrenal Cortex; Aldosterone; Angiotensin II; Anilides; Cell Line, Tumor; Cytochrome P-450 CYP11B2; Drug Combinations; eIF-2 Kinase; Fatty Acids; Gene Expression Regulation; Humans; Hydrocortisone; Phosphorylation; Pioglitazone; PPAR gamma; Protein Biosynthesis; RNA, Messenger; Signal Transduction; Thiazolidinediones; Transcription Factor CHOP | 2014 |
Analgesic tolerance to morphine is regulated by PPARγ.
Topics: Analgesics, Opioid; Anilides; Animals; Body Temperature; Drug Tolerance; Hot Temperature; Male; Mice, Inbred C57BL; Mice, Knockout; Morphine; Motor Activity; Pain; Pioglitazone; PPAR gamma; Thiazolidinediones | 2014 |
The glucagon-like peptide 1 receptor agonist enhances intrinsic peroxisome proliferator-activated receptor γ activity in endothelial cells.
Topics: Anilides; Colforsin; Cyclic AMP-Dependent Protein Kinases; Endothelial Cells; Exenatide; Gene Expression; Glucagon-Like Peptide-1 Receptor; Human Umbilical Vein Endothelial Cells; Humans; Intercellular Adhesion Molecule-1; Isoquinolines; NADPH Oxidase 1; NADPH Oxidases; NF-kappa B; Peptides; Phosphorylation; Pioglitazone; PPAR gamma; Protein Kinase Inhibitors; Receptor Cross-Talk; Receptors, Glucagon; Signal Transduction; Sulfonamides; Thiazolidinediones; Vascular Cell Adhesion Molecule-1; Venoms | 2014 |
PPARγ activation attenuates opioid consumption and modulates mesolimbic dopamine transmission.
Topics: Anilides; Animals; Conditioning, Operant; Dopamine; Dopaminergic Neurons; gamma-Aminobutyric Acid; Heroin; Hypoglycemic Agents; Male; Mice, Transgenic; Morphine; Narcotics; Nucleus Accumbens; Pioglitazone; PPAR gamma; Prefrontal Cortex; Rats; Rats, Wistar; Self Administration; Synaptic Transmission; Thiazolidinediones; Time Factors; Ventral Tegmental Area | 2015 |
The effect of PPAR-γ agonist on (18)F-FDG PET imaging for differentiating tumors and inflammation lesions.
Topics: Anilides; Animals; Biological Transport; Cell Line, Tumor; Diagnosis, Differential; Female; Fluorodeoxyglucose F18; Gene Expression Regulation, Neoplastic; Glucose; Glucose Transporter Type 1; Glucose Transporter Type 3; Humans; Inflammation; Macrophages; Mice; Neoplasms; Pioglitazone; Positron-Emission Tomography; PPAR gamma; Thiazolidinediones; Tissue Distribution | 2015 |
Antidepressant-like effect of atorvastatin in the forced swimming test in mice: the role of PPAR-gamma receptor and nitric oxide pathway.
Topics: Anilides; Animals; Antidepressive Agents; Atorvastatin; Depression; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Imipramine; Male; Mice; Motor Activity; NG-Nitroarginine Methyl Ester; Nitric Oxide; Pioglitazone; PPAR gamma; Pyrroles; Signal Transduction; Swimming; Thiazolidinediones | 2014 |
Involvement of PPAR receptors in the anticonvulsant effects of a cannabinoid agonist, WIN 55,212-2.
Topics: Anilides; Animals; Anticonvulsants; Benzoxazines; Cannabinoid Receptor Antagonists; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Male; Mice; Morpholines; Naphthalenes; Oxazoles; Pentylenetetrazole; Peroxisome Proliferator-Activated Receptors; Pioglitazone; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Seizures; Thiazolidinediones; Tyrosine | 2015 |
Pioglitazone inhibits high glucose-induced expression of receptor for advanced glycation end products in coronary artery smooth muscle cells.
Topics: Anilides; Animals; Coronary Vessels; Gene Expression Regulation; Glucose; Male; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Pioglitazone; PPAR gamma; Rats; Reactive Oxygen Species; Receptor for Advanced Glycation End Products; Receptors, Immunologic; RNA, Messenger; Thiazolidinediones | 2015 |
Pioglitazone prevents morphine antinociceptive tolerance via ameliorating neuroinflammation in rat cerebral cortex.
Topics: Administration, Oral; Analgesics, Opioid; Anilides; Animals; Cerebral Cortex; Cytokines; Drug Tolerance; Encephalitis; Hypoglycemic Agents; Injections, Intraperitoneal; Male; Morphine; NF-kappa B; Pain Measurement; Pioglitazone; PPAR gamma; Rats; Rats, Wistar; Thiazolidinediones | 2015 |
Smooth Muscle Peroxisome Proliferator-Activated Receptor γ Plays a Critical Role in Formation and Rupture of Cerebral Aneurysms in Mice In Vivo.
Topics: Aneurysm, Ruptured; Angiotensin II; Anilides; Animals; Cerebral Arteries; Endothelium, Vascular; Gene Expression Regulation; Genes, Dominant; Hypertension; Inflammation Mediators; Intracranial Aneurysm; Mice; Mice, Transgenic; Muscle, Smooth, Vascular; Mutation; Myocytes, Smooth Muscle; Organ Specificity; Pancreatic Elastase; Pioglitazone; PPAR gamma; Subarachnoid Hemorrhage; Thiazolidinediones; Up-Regulation; Vasculitis | 2015 |
Protective Role of Peroxisome Proliferator-Activated Receptor-γ in the Development of Intracranial Aneurysm Rupture.
Topics: Aneurysm, Ruptured; Anilides; Animals; Cerebral Arteries; Cytokines; Hypoglycemic Agents; Intracranial Aneurysm; Macrophages; Mice; Mice, Knockout; Pioglitazone; PPAR gamma; Thiazolidinediones | 2015 |
The peroxisome proliferator activated receptor gamma agonist pioglitazone increases functional expression of the glutamate transporter excitatory amino acid transporter 2 (EAAT2) in human glioblastoma cells.
Topics: Anilides; Animals; Brain; Brain Neoplasms; Cell Line, Tumor; Cell Survival; Dose-Response Relationship, Drug; Excitatory Amino Acid Transporter 2; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Glioblastoma; Glutamate Plasma Membrane Transport Proteins; Glutamic Acid; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Humans; Neoplasm Transplantation; Pioglitazone; PPAR gamma; Rats; Rats, Wistar; Seizures; Thiazolidinediones | 2015 |
Crosstalk between peroxisome proliferator-activated receptor-γ and mineralcorticoid receptor in TNF-α activated renal tubular cell.
Topics: Anilides; Anti-Inflammatory Agents; Cell Line; Drug Synergism; Eplerenone; Humans; Intercellular Adhesion Molecule-1; Interleukin-6; Kidney Tubules, Proximal; Mineralocorticoid Receptor Antagonists; NF-kappa B; Pioglitazone; PPAR gamma; Receptors, Mineralocorticoid; Spironolactone; Thiazolidinediones; Tumor Necrosis Factor-alpha | 2015 |
Activation of central PPAR-γ attenuates angiotensin II-induced hypertension.
Topics: Angiotensin II; Anilides; Animals; Blood Pressure; Brain; Disease Models, Animal; Hypertension; Infusions, Intraventricular; Infusions, Subcutaneous; Male; Pioglitazone; PPAR gamma; Rats; Rats, Sprague-Dawley; Renin-Angiotensin System; Sympathetic Nervous System; Thiazolidinediones; Ventricular Remodeling | 2015 |
Apoptotic Mechanisms of Peroxisome Proliferator-Activated Receptor-γ Activation in Acinar Cells During Acute Pancreatitis.
Topics: Acinar Cells; Acute Disease; Amylases; Anilides; Animals; Apoptosis; bcl-2-Associated X Protein; Blotting, Western; Caspases; Cell Line, Tumor; Cell Survival; Ceruletide; Cytokines; Enzyme-Linked Immunosorbent Assay; Humans; Male; Membrane Potential, Mitochondrial; Pancreatitis; Pioglitazone; PPAR gamma; Proto-Oncogene Proteins c-bcl-2; Rats, Sprague-Dawley; Severity of Illness Index; Thiazolidinediones | 2016 |
Regulation of brain PPARgamma2 contributes to ketogenic diet anti-seizure efficacy.
Topics: 3-Hydroxybutyric Acid; Age Factors; Anilides; Animals; Animals, Newborn; Anticonvulsants; Blood Glucose; Brain; Convulsants; Diet, Ketogenic; Disease Models, Animal; Drinking; Epilepsy; Flurothyl; Gene Expression Regulation, Developmental; Hypoglycemic Agents; Kv1.1 Potassium Channel; Mice; Mice, Inbred C57BL; Mice, Knockout; Pioglitazone; PPAR gamma; Thiazolidinediones | 2017 |
Genetic Deletion of Neuronal PPARγ Enhances the Emotional Response to Acute Stress and Exacerbates Anxiety: An Effect Reversed by Rescue of Amygdala PPARγ Function.
Topics: Amygdala; Anilides; Animals; Anxiety; Corticosterone; Emotions; Exploratory Behavior; Glutamate Decarboxylase; Hippocampus; Male; Mice; Mice, Knockout; Microinjections; Neurons; Pioglitazone; PPAR gamma; Stress, Psychological; Thiazolidinediones | 2016 |
PPARγ agonism attenuates cocaine cue reactivity.
Topics: Anilides; Animals; Behavior, Animal; Cocaine; Cocaine-Related Disorders; Craving; Cues; Dopamine Uptake Inhibitors; Drug-Seeking Behavior; Locomotion; MAP Kinase Signaling System; Pioglitazone; PPAR gamma; Rats; Rats, Sprague-Dawley; Recurrence; Self Administration | 2018 |
PPARγ activation ameliorates postoperative cognitive decline probably through suppressing hippocampal neuroinflammation in aged mice.
Topics: Aging; Anilides; Animals; Brain-Derived Neurotrophic Factor; Cells, Cultured; Cognitive Dysfunction; Cytokines; Disease Models, Animal; Hippocampus; Humans; Inflammation Mediators; Laparotomy; Male; Mice; Mice, Inbred C57BL; Microglia; Neurogenic Inflammation; Pioglitazone; Postoperative Complications; PPAR gamma; Thiazolidinediones | 2017 |
Pharmacological evidence for systemic and peripheral antinociceptive activities of pioglitazone in the rat formalin test: Role of PPARγ and nitric oxide.
Topics: Analgesics; Anilides; Animals; Drug Interactions; Formaldehyde; Locomotion; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Pioglitazone; PPAR gamma; Rats; Rats, Wistar; Thiazolidinediones | 2017 |
PPARγ Agonists Attenuate Trigeminal Neuropathic Pain.
Topics: Analgesics, Non-Narcotic; Anilides; Animals; Disease Models, Animal; Facial Pain; Hyperalgesia; Male; Mice, Inbred C57BL; Neuralgia; Pioglitazone; PPAR alpha; PPAR delta; PPAR gamma; Random Allocation; Thiazolidinediones; Trigeminal Nerve Injuries; Trigeminal Nuclei; Vibrissae | 2017 |
Pioglitazone attenuates lipopolysaccharide-induced depression-like behaviors, modulates NF-κB/IL-6/STAT3, CREB/BDNF pathways and central serotonergic neurotransmission in mice.
Topics: Anilides; Animals; Antidepressive Agents; Brain-Derived Neurotrophic Factor; Cells, Cultured; Cyclic AMP Response Element-Binding Protein; Depression; Humans; Interleukin-6; Lipopolysaccharides; Male; Mice; Mice, Inbred C57BL; NF-kappa B; Pioglitazone; PPAR gamma; Serotonergic Neurons; Signal Transduction; STAT3 Transcription Factor; Synaptic Transmission; Thiazolidinediones | 2017 |
Pioglitazone Alleviates Cardiac Fibrosis and Inhibits Endothelial to Mesenchymal Transition Induced by Pressure Overload.
Topics: Anilides; Animals; Cardiomegaly; Cell Differentiation; Echocardiography; Fibrosis; Hemodynamics; Human Umbilical Vein Endothelial Cells; Humans; Male; Mice; Mice, Inbred C57BL; Myocardium; Pioglitazone; PPAR gamma; Pressure; Signal Transduction; Smad Proteins; Thiazolidinediones; Transforming Growth Factor beta; Vimentin | 2018 |
PI3K/AKT/JNK/p38 signalling pathway-mediated neural apoptosis in the prefrontal cortex of mice is involved in the antidepressant-like effect of pioglitazone.
Topics: Anilides; Animals; Antidepressive Agents; Apoptosis; Body Weight; Gene Expression Regulation; JNK Mitogen-Activated Protein Kinases; Male; MAP Kinase Signaling System; Mice; Mice, Inbred C57BL; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Phosphorylation; Pioglitazone; PPAR gamma; Prefrontal Cortex; Proto-Oncogene Proteins c-akt | 2018 |
Regulation of the metabolism of apolipoprotein M and sphingosine 1-phosphate by hepatic PPARγ activity.
Topics: Anilides; Animals; Apolipoproteins M; Hep G2 Cells; Humans; Liver; Lysophospholipids; Mice; Pioglitazone; PPAR gamma; Sphingosine | 2018 |
Telmisartan Protects a Microglia Cell Line from LPS Injury Beyond AT1 Receptor Blockade or PPARγ Activation.
Topics: Angiotensin II Type 1 Receptor Blockers; Anilides; Animals; Brain Diseases; Cell Line; Down-Regulation; Inflammation Mediators; Interleukin-1beta; Interleukin-6; Lipopolysaccharides; Mice, Inbred C57BL; Microglia; Neuroprotective Agents; Pioglitazone; PPAR gamma; Telmisartan; Up-Regulation | 2019 |
[Activation of PPARγ pathway enhances cellular anti-oxidant capacity to protect long-term cultured primary rat neural cells from apoptosis].
Topics: Anilides; Animals; Apoptosis; Cell Proliferation; Cell Survival; Cells, Cultured; Cellular Senescence; Neurons; Pioglitazone; PPAR gamma; Rats | 2019 |
Activation of PPARγ Attenuates the Expression of Physical and Affective Nicotine Withdrawal Symptoms through Mechanisms Involving Amygdala and Hippocampus Neurotransmission.
Topics: Affect; Amygdala; Anilides; Animals; Anxiety; Behavior, Animal; gamma-Aminobutyric Acid; Hippocampus; Male; Mice, Knockout; Microinjections; Neurons; Pioglitazone; PPAR gamma; Rats; Rats, Wistar; Smoking Cessation; Substance Withdrawal Syndrome; Synaptic Transmission | 2019 |
Role of peroxisome proliferators-activated receptor-gamma in advanced glycation end product-mediated functional loss of voltage-gated potassium channel in rat coronary arteries.
Topics: Anilides; Animals; Cells, Cultured; Coronary Vessels; Glycation End Products, Advanced; Kv1.2 Potassium Channel; Kv1.5 Potassium Channel; Male; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Oxidative Stress; Pioglitazone; PPAR gamma; Rats, Sprague-Dawley; Serum Albumin, Bovine; Signal Transduction; Vasodilation | 2020 |
Further evidence for the involvement of the PPARγ system on alcohol intake and sensitivity in rodents.
Topics: Alcohol Drinking; Anilides; Animals; Dose-Response Relationship, Drug; Ethanol; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Mice, Transgenic; Pioglitazone; PPAR gamma; Rats; Rats, Wistar; Rodentia | 2020 |
Rice Bran Extract Protected against LPS-Induced Neuroinflammation in Mice through Targeting PPAR-γ Nuclear Receptor.
Topics: Anilides; Animals; Brain; Cyclooxygenase 2; Esters; Fatty Acids; Gene Expression Regulation; Inflammation; Lipopolysaccharides; Male; Mice; Neuroprotective Agents; NF-kappa B; NF-KappaB Inhibitor alpha; Oryza; Pioglitazone; Plant Extracts; PPAR gamma; Protein Binding; Response Elements; Sumoylation; Tumor Necrosis Factor-alpha; Up-Regulation | 2021 |
PPAR-γ with its anti-fibrotic action could serve as an effective therapeutic target in T-2 toxin-induced cardiac fibrosis of rats.
Topics: Anilides; Animals; Cardiomyopathies; Cell Line; Collagen; Fibrosis; Male; Myocardium; Pioglitazone; PPAR gamma; Rats, Wistar; Signal Transduction; T-2 Toxin; Transforming Growth Factor beta1; Up-Regulation | 2021 |
Glioblastoma cell migration is directed by electrical signals.
Topics: Anilides; Cell Differentiation; Cell Line, Tumor; Cell Movement; Electricity; Electrodes; Electromagnetic Fields; ErbB Receptors; Gene Expression Regulation, Neoplastic; Humans; Neoplastic Stem Cells; Neuroglia; Phosphatidylinositol 3-Kinases; Pioglitazone; PPAR gamma; Proto-Oncogene Proteins c-akt; PTEN Phosphohydrolase; Signal Transduction; Taxis Response | 2021 |
Peroxisome proliferator-activated receptor ɣ agonist mediated inhibition of heparanase expression reduces proteinuria.
Topics: Animals; Diabetes Mellitus, Type 2; Doxorubicin; Endothelial Cells; Humans; Kidney Diseases; Mice; Pioglitazone; PPAR gamma; PPAR-gamma Agonists; Proteinuria; Rats; Thiazolidinediones | 2023 |
The PPAR-γ Agonist Pioglitazone Modulates Proliferation and Migration in HUVEC, HAOSMC and Human Arteriovenous Fistula-Derived Cells.
Topics: Arteriovenous Fistula; Arteriovenous Shunt, Surgical; Cell Proliferation; Humans; Myocytes, Smooth Muscle; Pioglitazone; PPAR gamma; PPAR-gamma Agonists; Thiazolidinediones; Umbilical Veins | 2023 |
The role of PPAR-γ in memory deficits induced by prenatal and lactation alcohol exposure in mice.
Topics: Animals; Child; Female; Fetal Alcohol Spectrum Disorders; Humans; Lactation; Memory Disorders; Mice; Pioglitazone; PPAR gamma; Pregnancy; Thiazolidinediones | 2023 |