Compounds > pioglitazone
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pioglitazone and angiotensin ii

pioglitazone has been researched along with angiotensin ii in 45 studies

Research

Studies (45)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's21 (46.67)29.6817
2010's23 (51.11)24.3611
2020's1 (2.22)2.80

Authors

AuthorsStudies
Bilter, GK; Dias, J; Huang, Z; Keon, BH; Lamerdin, J; MacDonald, ML; Michnick, SW; Minami, T; Owens, S; Shang, Z; Westwick, JK; Yu, H1
Asakawa, M; Hasegawa, H; Kadowaki, T; Komuro, I; Kubota, N; Masuda, Y; Nagai, T; Saito, T; Takano, H; Uozumi, H1
Amiri, F; Cohn, JS; Diep, QN; El Mabrouk, M; Endemann, D; Neves, MF; Schiffrin, EL; Virdis, A1
Chen, J; Hu, B; Li, D; Mehta, JL1
Ago, T; Iida, M; Iwase, M; Kitazono, T; Nakamura, U; Ueta, M; Wakisaka, M; Yoshinari, M1
Hayashi, K; Homma, K; Kanda, T; Saruta, T; Takamatsu, I; Tatematsu, S; Wakino, S; Yoshioka, K1
Asbun, J; Villarreal, FJ1
Chen, J; Chen, K; Li, D; Mehta, JL; Zhang, X1
Maeda, T; Makino, N; Oyama, J; Satoh, S; Sugano, M1
Chen, J; Mehta, JL1
Burnier, M; Cefai, D; Maillard, M; Nussberger, J; Perregaux, C; Zanchi, A1
Sheng, L; Wu, SM; Yang, W; Ye, P1
Gaikwad, AB; Ramarao, P; Viswanad, B1
Fang, NY; Gao, PJ; Guo, SJ; Han, WQ; Shen, WL; Wu, LY; Zhang, J; Zhu, DL1
Egawa, T; Hanafusa, N; Kawasaki, H; Mio, M; Takatori, S; Yabumae, N; Zamami, Y1
Akasaka, T; Goto, M; Ikejima, H; Imanishi, T; Kobayashi, K; Kuroi, A; Mochizuki, S; Yoshida, K1
Caglayan, E; Collins, AR; Erdmann, E; Hsueh, WA; Liu, J; Lyon, CJ; Peterson, LE; Rosenkranz, S; Ross, RS; Stauber, B; Tangirala, RK; Yin, F1
Akasaka, T; Ikejima, H; Imanishi, T; Kobayashi, K; Kuroi, A1
Koide, N; Miyashita, Y; Murano, T; Saiki, A; Shirai, K; Watanabe, F1
Akagami, T; Doi, T; Masuyama, T; Mori, Y; Naka, T; Ohyanagi, M; Sakoda, T; Tsujino, T1
Campbell, JH; Cullen, B; Daugherty, A; Golledge, J; Moran, CS; Norman, PE; Rush, C; Secomb, E; Wood, F1
Cheng, X; Furukawa, M; Li, P; Murohara, T; Nagata, K; Ohashi, T; Ouchi, N; Shibata, R; Shimano, M; Unno, K1
Endo, K; Koide, N; Miyashita, Y; Murano, T; Ohira, M; Oyama, T; Saiki, A; Shirai, K1
Bruemmer, D; Daugherty, A; Golledge, J; Ijaz, T; Subramanian, V1
Liu, YX; Wu, SM; Ye, P1
Furuta, K; Hongo, M; Ishizaka, N; Nagai, R; Saito, K; Sakamoto, A1
Hongo, M; Ishizaka, N; Nagai, R; Saito, K; Sakamoto, A1
Kong, X; Li, XY; Ma, MZ; Qin, L; Su, Q; Wang, GD; Zhang, DY; Zhang, Y1
Auger, C; Kang, M; Kim, KR; Lee, JO; Oak, MH; Park, DH; Schini-Kerth, VB1
Gu, J; Guo, M; Liu, F; Liu, X; Song, ZP; Wang, QX; Zhang, DD1
Aguado, A; Alonso, MJ; Barrús, MT; Hernanz, R; Martín, A; Martínez-Revelles, S; Palacios, R; Pérez-Girón, JV; Salaices, M1
Bollag, WB; Chen, X; Choudhary, V; Olala, L; Pan, ZQ; Seremwe, M; Tsai, YY; Xie, D1
Chen, XQ; Guo, M; Jiang, WF; Liu, F; Liu, X; Wang, QX; Zhang, MJ; Zhou, L1
Gu, J; Hu, W; Liu, X1
Liu, B; Wang, G; Wang, J1
Chalouhi, N; Chu, Y; Faraci, FM; Gu, H; Hasan, DM; Heistad, DD; Sigmund, CD; Starke, RM; Wilson, K1
Beltz, TG; Felder, RB; Guo, F; Johnson, AK; Wei, SG; Xue, BJ; Yu, Y; Zhang, ZH1
Charolidi, N; Cockerill, GW; Laing, K; Nohturfft, A; Pearce, S; Pirianov, G; Torsney, E1
Higashikuni, Y; Hongo, M; Imai, Y; Ishizaka, N; Koike, K; Komuro, I; Nagai, R; Sakamoto, A1
Egashira, K; Katsuki, S; Koga, J; Matoba, T; Nakano, K; Nakashiro, S; Sunagawa, K; Tokutome, M; Umezu, R1
Achike, FI; Kunasegaran, T; Murugan, DD; Mustafa, MR1
Kanasaki, K; Kanasaki, M; Koya, D; Takeda, S; Ueki, N1
Al-Shorbagy, MY; Ali, RM; El-Abhar, HS; Helmy, MW1
Abdulla, MH; Afzal, S; Akhtar, S; Binti Abdullah, NA; Eseyin, OA; Johns, EJ; Sattar, MA1
Abuiessa, SA; El-Gowelli, HM; El-Gowilly, SM; El-Mas, MM; Helmy, MM1

Trials

2 trial(s) available for pioglitazone and angiotensin ii

ArticleYear
Pioglitazone decreases plasma angiotensin II concentration in type 2 diabetes.
    Journal of atherosclerosis and thrombosis, 2010, Jun-30, Volume: 17, Issue:6

    Topics: Adipocytes; Aged; Angiotensin II; Biomarkers; Diabetes Mellitus, Type 2; Female; Humans; Hypoglycemic Agents; Insulin; Lipoprotein Lipase; Male; Middle Aged; Pioglitazone; ras Proteins; Thiazolidinediones

2010
Beneficial effects of pioglitazone on retardation of persistent atrial fibrillation progression in diabetes mellitus patients.
    International heart journal, 2014, Volume: 55, Issue:6

    Topics: Aged; Angiotensin II; Atrial Fibrillation; Diabetes Complications; Disease Progression; Double-Blind Method; Female; Glycation End Products, Advanced; Heart Atria; Humans; Hypoglycemic Agents; Male; Middle Aged; Peptide Fragments; Pioglitazone; Procollagen; Thiazolidinediones

2014

Other Studies

43 other study(ies) available for pioglitazone and angiotensin ii

ArticleYear
Identifying off-target effects and hidden phenotypes of drugs in human cells.
    Nature chemical biology, 2006, Volume: 2, Issue:6

    Topics: Bacterial Proteins; Cell Line; Cell Proliferation; Cluster Analysis; Drug Design; Drug Evaluation, Preclinical; Genetics; Humans; Luminescent Proteins; Molecular Structure; Phenotype; Recombinant Fusion Proteins; Signal Transduction; Structure-Activity Relationship

2006
Peroxisome proliferator-activated receptor gamma plays a critical role in inhibition of cardiac hypertrophy in vitro and in vivo.
    Circulation, 2002, Mar-12, Volume: 105, Issue:10

    Topics: Actins; Angiotensin II; Animals; Atrial Natriuretic Factor; Body Weight; Cardiomegaly; Cell Size; Cells, Cultured; Chromans; Disease Models, Animal; Gene Expression; Heart; Heterozygote; Hypoglycemic Agents; Ligands; Mice; Mice, Knockout; Myocardium; Organ Size; Pioglitazone; Rats; Rats, Wistar; Receptors, Cytoplasmic and Nuclear; Rosiglitazone; Thiazoles; Thiazolidinediones; Transcription Factors; Troglitazone

2002
Structure, endothelial function, cell growth, and inflammation in blood vessels of angiotensin II-infused rats: role of peroxisome proliferator-activated receptor-gamma.
    Circulation, 2002, May-14, Volume: 105, Issue:19

    Topics: Aldosterone; Angiotensin II; Animals; Blood Pressure; Blood Vessels; Body Weight; Cell Cycle Proteins; Cell Division; Collagen; DNA; Drug Administration Schedule; Endothelium, Vascular; In Vitro Techniques; Inflammation; Injections, Subcutaneous; Lipids; Male; NF-kappa B; Pioglitazone; Platelet Endothelial Cell Adhesion Molecule-1; Rats; Rats, Sprague-Dawley; Receptors, Angiotensin; Receptors, Cytoplasmic and Nuclear; Renin; Rosiglitazone; Thiazoles; Thiazolidinediones; Transcription Factors; Vascular Cell Adhesion Molecule-1; Vasoconstrictor Agents; Vasodilator Agents

2002
Pioglitazone inhibits LOX-1 expression in human coronary artery endothelial cells by reducing intracellular superoxide radical generation.
    Arteriosclerosis, thrombosis, and vascular biology, 2003, Volume: 23, Issue:12

    Topics: Angiotensin II; Cell Adhesion; Cell Line; Coronary Vessels; Endothelium, Vascular; Humans; Lipoproteins, LDL; Monocytes; Oxidation-Reduction; Oxidative Stress; Pioglitazone; Receptors, LDL; RNA, Messenger; Superoxides; Thiazolidinediones; Tumor Necrosis Factor-alpha

2003
PPARgamma ligands attenuate mesangial contractile dysfunction in high glucose.
    Kidney international, 2004, Volume: 65, Issue:3

    Topics: Actins; Angiotensin II; Animals; Aspirin; Cells, Cultured; Cyclooxygenase Inhibitors; DNA, Antisense; Enzyme Inhibitors; Flavonoids; Gene Expression; Glomerular Mesangium; Glucose; Hypoglycemic Agents; Indomethacin; Ligands; Pioglitazone; Prostaglandin D2; Rats; Rats, Sprague-Dawley; Receptors, Cytoplasmic and Nuclear; Thiazolidinediones; Transcription Factors; Vasoconstrictor Agents

2004
Peroxisome proliferator-activated receptor gamma ligands inhibit Rho/Rho kinase pathway by inducing protein tyrosine phosphatase SHP-2.
    Circulation research, 2004, Sep-03, Volume: 95, Issue:5

    Topics: Angiotensin II; Animals; Blood Pressure; Cell Cycle Proteins; Cells, Cultured; Chromans; Hypertension; Intracellular Signaling Peptides and Proteins; Ligands; Male; Muscle, Smooth, Vascular; Pioglitazone; Platelet-Derived Growth Factor; PPAR gamma; Protein Phosphatase 2; Protein Serine-Threonine Kinases; Protein Tyrosine Phosphatase, Non-Receptor Type 11; Protein Tyrosine Phosphatases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-vav; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Rats, Sprague-Dawley; rho GTP-Binding Proteins; rho-Associated Kinases; Signal Transduction; Thiazolidinediones; Troglitazone

2004
Peroxisome proliferator-activated receptors ligands, oxidative stress, and cardiac fibroblast extracellular matrix turnover.
    Hypertension (Dallas, Tex. : 1979), 2004, Volume: 44, Issue:5

    Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Antioxidants; Extracellular Matrix; Fibroblasts; Humans; Ligands; Myocardium; Oxidative Stress; Peroxisome Proliferator-Activated Receptors; Pioglitazone; Thiazolidinediones

2004
Angiotensin II regulation of collagen type I expression in cardiac fibroblasts: modulation by PPAR-gamma ligand pioglitazone.
    Hypertension (Dallas, Tex. : 1979), 2004, Volume: 44, Issue:5

    Topics: Angiotensin II; Animals; Cells, Cultured; Collagen Type I; Fibroblasts; Ligands; Male; Matrix Metalloproteinase 1; Myocardium; NF-kappa B; Oxidation-Reduction; Oxidative Stress; Pioglitazone; PPAR gamma; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Thiazolidinediones

2004
Peroxisome proliferator-activated receptor-gamma ligands attenuate brain natriuretic peptide production and affect remodeling in cardiac fibroblasts in reoxygenation after hypoxia.
    Cell biochemistry and biophysics, 2006, Volume: 44, Issue:1

    Topics: Angiotensin II; Animals; Animals, Newborn; Blotting, Northern; Blotting, Western; Cell Hypoxia; Cells, Cultured; Collagen Type I; Collagen Type III; Electrophoretic Mobility Shift Assay; Fibroblasts; Gene Expression; Ligands; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Muscle Cells; Myocardial Reperfusion Injury; Myocardium; Natriuretic Peptide, Brain; NF-kappa B; Oxygen; Pioglitazone; PPAR gamma; Prostaglandin D2; Rats; Rats, Wistar; RNA, Messenger; Thiazolidinediones; Tissue Inhibitor of Metalloproteinase-1

2006
Angiotensin II-mediated oxidative stress and procollagen-1 expression in cardiac fibroblasts: blockade by pravastatin and pioglitazone.
    American journal of physiology. Heart and circulatory physiology, 2006, Volume: 291, Issue:4

    Topics: Angiotensin II; Animals; Antioxidants; Cells, Cultured; Collagen Type I; Drug Synergism; Fibroblasts; Gene Expression Regulation; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Mice; Mice, Inbred C57BL; Mitogen-Activated Protein Kinases; Myocardium; NF-kappa B; Oxidative Stress; Pioglitazone; Pravastatin; RNA, Messenger; Superoxides; Thiazolidinediones; Tocopherols; Transcription Factor AP-1

2006
The PPARgamma agonist pioglitazone modifies the vascular sodium-angiotensin II relationship in insulin-resistant rats.
    American journal of physiology. Endocrinology and metabolism, 2006, Volume: 291, Issue:6

    Topics: Angiotensin II; Animals; Blood Pressure; Blood Vessels; Body Weight; Diet; Dose-Response Relationship, Drug; Eating; Glucose Tolerance Test; Heart Rate; Hypoglycemic Agents; Insulin Resistance; Membranes; Pioglitazone; PPAR gamma; Rats; Rats, Zucker; Receptor, Angiotensin, Type 1; Renal Circulation; RNA, Messenger; Sodium; Sodium, Dietary; Thiazolidinediones

2006
Effect of pioglitazone on the expression of inflammatory cytokines in attenuating rat cardiomyocyte hypertrophy.
    Methods and findings in experimental and clinical pharmacology, 2006, Volume: 28, Issue:10

    Topics: Angiotensin II; Animals; Anti-Inflammatory Agents; Atrial Natriuretic Factor; Cardiomegaly; Cells, Cultured; Interleukin-1beta; Interleukin-6; Leucine; Myocytes, Cardiac; Natriuretic Peptide, Brain; Pioglitazone; PPAR gamma; Rats; Rats, Wistar; RNA, Messenger; Thiazolidinediones

2006
PPAR gamma agonists partially restores hyperglycemia induced aggravation of vascular dysfunction to angiotensin II in thoracic aorta isolated from rats with insulin resistance.
    Pharmacological research, 2007, Volume: 55, Issue:5

    Topics: Angiotensin II; Animals; Aorta, Thoracic; Blood Pressure; Dietary Fats; Disease Models, Animal; Dose-Response Relationship, Drug; Hyperglycemia; Hypoglycemic Agents; Insulin Resistance; Male; Pioglitazone; PPAR gamma; Prediabetic State; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1; Rosiglitazone; Streptozocin; Thiazolidinediones; Vasoconstriction; Vasoconstrictor Agents

2007
Peroxisome proliferator-activated receptor-gamma agonists attenuate angiotensin II-induced collagen type I expression in adventitial fibroblasts.
    Clinical and experimental pharmacology & physiology, 2008, Volume: 35, Issue:1

    Topics: Acetylcysteine; Angiotensin II; Animals; Cells, Cultured; Collagen Type I; Connective Tissue; Dose-Response Relationship, Drug; Fibroblasts; Free Radical Scavengers; Male; NF-kappa B; Oxidative Stress; Pioglitazone; PPAR gamma; Prostaglandin D2; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; RNA, Messenger; Thiazolidinediones; Time Factors; Transcription Factor AP-1

2008
Pioglitazone opposes neurogenic vascular dysfunction associated with chronic hyperinsulinaemia.
    British journal of pharmacology, 2008, Volume: 153, Issue:7

    Topics: Administration, Oral; Angiotensin II; Animals; Blood Glucose; Blood Pressure; Chronic Disease; Disease Models, Animal; Hyperinsulinism; Hypertension; Hypoglycemic Agents; Insulin; Insulin Resistance; Male; Norepinephrine; Pioglitazone; Random Allocation; Rats; Rats, Wistar; Thiazolidinediones; Triglycerides; Vasoconstriction

2008
Effects of pioglitazone on nitric oxide bioavailability measured using a catheter-type nitric oxide sensor in angiotensin II-infusion rabbit.
    Hypertension research : official journal of the Japanese Society of Hypertension, 2008, Volume: 31, Issue:1

    Topics: Acetylcholine; Angiotensin II; Animals; Biopterins; Biosensing Techniques; Blood Pressure; Calibration; Catheterization; Enzyme Inhibitors; Heart Rate; Hypoglycemic Agents; Immunohistochemistry; Male; Nitric Oxide; omega-N-Methylarginine; Pioglitazone; PPAR gamma; Rabbits; Thiazolidinediones; Tyrosine; Vasoconstrictor Agents; Vasodilator Agents

2008
Differential roles of cardiomyocyte and macrophage peroxisome proliferator-activated receptor gamma in cardiac fibrosis.
    Diabetes, 2008, Volume: 57, Issue:9

    Topics: Adiponectin; Angiotensin II; Animals; Cardiomegaly; Chemotaxis; Female; Fibrosis; Hypoglycemic Agents; Macrophages; Male; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Mice, Knockout; Myocardium; Myocytes, Cardiac; Pioglitazone; PPAR gamma; Thiazolidinediones; Vasoconstrictor Agents

2008
Pioglitazone inhibits angiotensin II-induced senescence of endothelial progenitor cell.
    Hypertension research : official journal of the Japanese Society of Hypertension, 2008, Volume: 31, Issue:4

    Topics: Angiotensin II; Cells, Cultured; Cellular Senescence; Drug Interactions; Gene Expression; Hematopoietic Stem Cells; Humans; Hypertension; Hypoglycemic Agents; Membrane Glycoproteins; NADPH Oxidase 2; NADPH Oxidases; Oxidative Stress; Peroxynitrous Acid; Pioglitazone; Receptor, Angiotensin, Type 1; Superoxides; Telomerase; Thiazolidinediones; Vasoconstrictor Agents

2008
Suppression of lipoprotein lipase expression in 3T3-L1 cells by inhibition of adipogenic differentiation through activation of the renin-angiotensin system.
    Metabolism: clinical and experimental, 2008, Volume: 57, Issue:8

    Topics: 3T3-L1 Cells; Adipocytes; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Angiotensinogen; Animals; Azo Compounds; Blotting, Western; Cell Differentiation; Lipoprotein Lipase; Mice; Microscopy, Phase-Contrast; Pioglitazone; PPAR gamma; Renin-Angiotensin System; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tetrazoles; Thiazolidinediones; Valine; Valsartan

2008
Aldosterone induces interleukin-18 through endothelin-1, angiotensin II, Rho/Rho-kinase, and PPARs in cardiomyocytes.
    American journal of physiology. Heart and circulatory physiology, 2008, Volume: 295, Issue:3

    Topics: Aldosterone; Angiotensin II; Animals; Animals, Newborn; Bezafibrate; Cells, Cultured; DNA Primers; Dose-Response Relationship, Drug; Endothelin-1; Interleukin-18; Myocytes, Cardiac; NF-kappa B; Oligopeptides; Peptides, Cyclic; Peroxisome Proliferator-Activated Receptors; Pioglitazone; Piperidines; Rats; Rats, Sprague-Dawley; rho-Associated Kinases; Thiazolidinediones

2008
Peroxisome proliferator-activated receptor ligands reduce aortic dilatation in a mouse model of aortic aneurysm.
    Atherosclerosis, 2010, Volume: 210, Issue:1

    Topics: Angiotensin II; Animals; Aortic Aneurysm, Abdominal; Apolipoproteins E; Fenofibrate; Immunohistochemistry; Ligands; Macrophages; Male; Mice; Osteopontin; Peroxisome Proliferator-Activated Receptors; Pioglitazone; Thiazolidinediones; Up-Regulation

2010
Evidence for the importance of adiponectin in the cardioprotective effects of pioglitazone.
    Hypertension (Dallas, Tex. : 1979), 2010, Volume: 55, Issue:1

    Topics: Adiponectin; AMP-Activated Protein Kinases; Angiotensin II; Animals; Blotting, Western; Cardiomegaly; Cardiotonic Agents; Collagen Type I; Collagen Type II; Extracellular Signal-Regulated MAP Kinases; Fibrosis; Hypoglycemic Agents; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Myocardium; Phosphorylation; Pioglitazone; Reverse Transcriptase Polymerase Chain Reaction; Thiazolidinediones

2010
Pioglitazone-induced reductions in atherosclerosis occur via smooth muscle cell-specific interaction with PPAR{gamma}.
    Circulation research, 2010, Oct-15, Volume: 107, Issue:8

    Topics: Angiotensin II; Animals; Aorta; Atherosclerosis; Cells, Cultured; Chemokine CCL2; Female; Hypoglycemic Agents; Male; Mice; Mice, Mutant Strains; Muscle, Smooth, Vascular; Pioglitazone; PPAR gamma; Receptors, LDL; Thiazolidinediones; Vasoconstrictor Agents

2010
[The role of peroxisome proliferator-activated receptor gamma in proliferation of cardiac non myocytes].
    Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology, 2006, Volume: 22, Issue:2

    Topics: Angiotensin II; Animals; Cell Proliferation; Cells, Cultured; Heart; Male; Myocardium; Pioglitazone; PPAR gamma; Prostaglandin D2; Rats; Rats, Wistar; Thiazolidinediones

2006
Pioglitazone ameliorates systolic and diastolic cardiac dysfunction in rat model of angiotensin II-induced hypertension.
    International journal of cardiology, 2013, Jul-31, Volume: 167, Issue:2

    Topics: Angiotensin II; Animals; Blood Pressure; Diastole; Disease Models, Animal; Heart Diseases; Hypertension; Hypoglycemic Agents; Male; Pioglitazone; Rats; Rats, Sprague-Dawley; Systole; Thiazolidinediones

2013
Reduction of renal lipid content and proteinuria by a PPAR-γ agonist in a rat model of angiotensin II-induced hypertension.
    European journal of pharmacology, 2012, May-05, Volume: 682, Issue:1-3

    Topics: Angiotensin II; Animals; Disease Models, Animal; Ferritins; Gene Expression Regulation; Heme Oxygenase-1; Hypertension; Iron; Kidney; Lipid Metabolism; Male; Pioglitazone; PPAR gamma; Proteinuria; Rats; Rats, Sprague-Dawley; Thiazolidinediones

2012
Pioglitazone enhances the blood pressure-lowering effect of losartan via synergistic attenuation of angiotensin II-induced vasoconstriction.
    Journal of the renin-angiotensin-aldosterone system : JRAAS, 2014, Volume: 15, Issue:3

    Topics: Acetylcholine; Angiotensin II; Animals; Aorta; Blood Pressure; Drug Synergism; Endothelium, Vascular; Losartan; Male; NADPH Oxidases; Nitric Oxide Synthase Type III; Nitroprusside; Phenylephrine; Pioglitazone; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1; Systole; Thiazolidinediones; Tyrosine; Vasoconstriction; Vasodilation

2014
An ethanolic extract of Lindera obtusiloba stems, YJP-14, improves endothelial dysfunction, metabolic parameters and physical performance in diabetic db/db mice.
    PloS one, 2013, Volume: 8, Issue:6

    Topics: Albuminuria; Angiotensin II; Animals; Aorta; Blood Glucose; Body Weight; Diabetes Mellitus, Type 2; Disease Models, Animal; Endothelium, Vascular; Ethanol; Exercise Tolerance; Gene Expression; Humans; Hyperglycemia; Hypoglycemic Agents; Lindera; Male; Mice; Mice, Transgenic; NADPH Oxidases; Nitric Oxide Synthase Type III; Pioglitazone; Plant Extracts; Prostaglandin-Endoperoxide Synthases; Receptor, Angiotensin, Type 1; Thiazolidinediones

2013
Beneficial effects of pioglitazone on atrial structural and electrical remodeling in vitro cellular models.
    Journal of molecular and cellular cardiology, 2013, Volume: 65

    Topics: Angiotensin II; Animals; Atrial Remodeling; Cardiotonic Agents; Cell Proliferation; Cyclic AMP Response Element-Binding Protein; Electrophysiological Phenomena; Fibroblasts; Heart Atria; Ion Channel Gating; Male; MAP Kinase Kinase Kinases; Mice; Mice, Inbred C57BL; Models, Biological; Phosphorylation; Phosphoserine; Pioglitazone; PPAR gamma; Protein Subunits; Receptor, Angiotensin, Type 1; Signal Transduction; Smad Proteins; Thiazolidinediones; TNF Receptor-Associated Factor 6; Transforming Growth Factor beta1

2013
Pioglitazone reduces angiotensin II-induced COX-2 expression through inhibition of ROS production and ET-1 transcription in vascular cells from spontaneously hypertensive rats.
    American journal of physiology. Heart and circulatory physiology, 2014, Jun-01, Volume: 306, Issue:11

    Topics: Angiotensin II; Animals; Aorta; Cyclooxygenase 2; Endothelin-1; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; NADPH Oxidases; Pioglitazone; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Reactive Oxygen Species; Thiazolidinediones; Transcription, Genetic

2014
The effect of pioglitazone on aldosterone and cortisol production in HAC15 human adrenocortical carcinoma cells.
    Molecular and cellular endocrinology, 2014, Aug-25, Volume: 394, Issue:1-2

    Topics: Adrenal Cortex; Aldosterone; Angiotensin II; Anilides; Cell Line, Tumor; Cytochrome P-450 CYP11B2; Drug Combinations; eIF-2 Kinase; Fatty Acids; Gene Expression Regulation; Humans; Hydrocortisone; Phosphorylation; Pioglitazone; PPAR gamma; Protein Biosynthesis; RNA, Messenger; Signal Transduction; Thiazolidinediones; Transcription Factor CHOP

2014
Pioglitazone inhibits angiotensin II-induced atrial fibroblasts proliferation via NF-κB/TGF-β1/TRIF/TRAF6 pathway.
    Experimental cell research, 2015, Jan-01, Volume: 330, Issue:1

    Topics: Adaptor Proteins, Vesicular Transport; Angiotensin II; Animals; Cell Proliferation; Fibrosis; Heart Atria; Male; Mice; Mice, Inbred C57BL; Myofibroblasts; NF-kappa B; Pioglitazone; Signal Transduction; Thiazolidinediones; TNF Receptor-Associated Factor 6; Transforming Growth Factor beta1

2015
Pioglitazone improves potassium channel remodeling induced by angiotensin II in atrial myocytes.
    Medical science monitor basic research, 2014, Oct-08, Volume: 20

    Topics: Angiotensin II; Animals; Atrial Remodeling; Cell Line; Electrophysiological Phenomena; Gene Expression Regulation; Heart Atria; Ion Channel Gating; Mice; Myocytes, Cardiac; Pioglitazone; Potassium Channels; Real-Time Polymerase Chain Reaction; RNA, Messenger; Thiazolidinediones

2014
Smooth Muscle Peroxisome Proliferator-Activated Receptor γ Plays a Critical Role in Formation and Rupture of Cerebral Aneurysms in Mice In Vivo.
    Hypertension (Dallas, Tex. : 1979), 2015, Volume: 66, Issue:1

    Topics: Aneurysm, Ruptured; Angiotensin II; Anilides; Animals; Cerebral Arteries; Endothelium, Vascular; Gene Expression Regulation; Genes, Dominant; Hypertension; Inflammation Mediators; Intracranial Aneurysm; Mice; Mice, Transgenic; Muscle, Smooth, Vascular; Mutation; Myocytes, Smooth Muscle; Organ Specificity; Pancreatic Elastase; Pioglitazone; PPAR gamma; Subarachnoid Hemorrhage; Thiazolidinediones; Up-Regulation; Vasculitis

2015
Activation of central PPAR-γ attenuates angiotensin II-induced hypertension.
    Hypertension (Dallas, Tex. : 1979), 2015, Volume: 66, Issue:2

    Topics: Angiotensin II; Anilides; Animals; Blood Pressure; Brain; Disease Models, Animal; Hypertension; Infusions, Intraventricular; Infusions, Subcutaneous; Male; Pioglitazone; PPAR gamma; Rats; Rats, Sprague-Dawley; Renin-Angiotensin System; Sympathetic Nervous System; Thiazolidinediones; Ventricular Remodeling

2015
Pioglitazone Identifies a New Target for Aneurysm Treatment: Role of Egr1 in an Experimental Murine Model of Aortic Aneurysm.
    Journal of vascular research, 2015, Volume: 52, Issue:2

    Topics: Angiotensin II; Animals; Aortic Aneurysm, Abdominal; Base Sequence; Binding Sites; Calcium Chloride; Cell Line, Tumor; Disease Models, Animal; Early Growth Response Protein 1; Female; Gene Expression Profiling; Gene Expression Regulation; Humans; Macrophages; Male; Mice, Knockout; Molecular Sequence Data; Pioglitazone; PPAR gamma; Promoter Regions, Genetic; RNA Interference; Signal Transduction; Thiazolidinediones; Time Factors; Transfection; TRPP Cation Channels

2015
Pioglitazone Reduces Vascular Lipid Accumulation in Angiotensin II-Induced Hypertensive Rat.
    Journal of atherosclerosis and thrombosis, 2015, Volume: 22, Issue:12

    Topics: AMP-Activated Protein Kinases; Angiotensin II; Animals; Aorta; Hypertension; Immunohistochemistry; Lipid Metabolism; Lipids; Male; Pioglitazone; PPAR gamma; Rats; Rats, Inbred SHR; Rats, Sprague-Dawley; Superoxides; Thiazolidinediones

2015
Pioglitazone-Incorporated Nanoparticles Prevent Plaque Destabilization and Rupture by Regulating Monocyte/Macrophage Differentiation in ApoE-/- Mice.
    Arteriosclerosis, thrombosis, and vascular biology, 2016, Volume: 36, Issue:3

    Topics: Administration, Intravenous; Angiotensin II; Animals; Apolipoproteins E; Atherosclerosis; Brachiocephalic Trunk; Cardiovascular Agents; Cathepsins; Cell Differentiation; Cells, Cultured; Chemistry, Pharmaceutical; Cytokines; Diet, High-Fat; Disease Models, Animal; Disease Progression; Drug Carriers; Inflammation Mediators; Lactic Acid; Macrophages, Peritoneal; Male; Matrix Metalloproteinases; Mice, 129 Strain; Mice, Inbred C57BL; Mice, Knockout; Monocytes; Nanoparticles; Phenotype; Pioglitazone; Plaque, Atherosclerotic; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Rupture, Spontaneous; Thiazolidinediones

2016
The bioflavonoid quercetin synergises with PPAR-γ agonist pioglitazone in reducing angiotensin-II contractile effect in fructose-streptozotocin induced diabetic rats.
    Biochimie, 2016, Volume: 125

    Topics: Angiotensin II; Animals; Aorta; Diabetes Mellitus, Experimental; Fructose; Male; Muscle Contraction; Pioglitazone; PPAR gamma; Quercetin; Rats; Rats, Sprague-Dawley; Thiazolidinediones

2016
Catechol-O-Methyltransferase Deficiency Leads to Hypersensitivity of the Pressor Response Against Angiotensin II.
    Hypertension (Dallas, Tex. : 1979), 2017, Volume: 69, Issue:6

    Topics: Angiotensin II; Animals; Catechol O-Methyltransferase; Drug Hypersensitivity; Female; Hypertension; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Pioglitazone; PPAR gamma; Pre-Eclampsia; Pregnancy; Pregnancy, Animal; Receptor, Angiotensin, Type 1; Reference Values; Thiazolidinediones; Vasoconstrictor Agents

2017
Role of Wnt4/β-catenin, Ang II/TGFβ, ACE2, NF-κB, and IL-18 in attenuating renal ischemia/reperfusion-induced injury in rats treated with Vit D and pioglitazone.
    European journal of pharmacology, 2018, Jul-15, Volume: 831

    Topics: Angiotensin II; Angiotensin-Converting Enzyme 2; Animals; beta Catenin; Cytoprotection; Disease Models, Animal; Hydroxycholecalciferols; Intercellular Adhesion Molecule-1; Interleukin-18; Kidney; Kidney Diseases; Male; Neutrophil Infiltration; NF-kappa B; Peptidyl-Dipeptidase A; Peroxidase; Pioglitazone; Rats, Sprague-Dawley; Reperfusion Injury; Thiazolidinediones; Time Factors; Transforming Growth Factor beta; Wnt Signaling Pathway; Wnt4 Protein

2018
Effect of pioglitazone on vasopressor responses to adrenergic agonists and angiotensin II in diabetic and non-diabetic spontaneously hypertensive rats.
    Pakistan journal of pharmaceutical sciences, 2018, Volume: 31, Issue:3

    Topics: Adrenergic Agonists; Angiotensin II; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Hemodynamics; Hypertension; Hypoglycemic Agents; Pioglitazone; Rats; Rats, Inbred SHR; Vasoconstrictor Agents

2018
Dysregulated ACE/Ang II/Ang1-7 signaling provokes cardiovascular and inflammatory sequelae of endotoxemia in weaning preeclamptic rats.
    European journal of pharmacology, 2022, Dec-05, Volume: 936

    Topics: Angiotensin II; Animals; Endotoxemia; Female; Humans; Losartan; Peptidyl-Dipeptidase A; Pioglitazone; Pre-Eclampsia; Pregnancy; Rats; Renin-Angiotensin System; Weaning

2022