Page last updated: 2024-08-16

pindolol and cimetidine

pindolol has been researched along with cimetidine in 32 studies

Research

Studies (32)

TimeframeStudies, this research(%)All Research%
pre-19908 (25.00)18.7374
1990's2 (6.25)18.2507
2000's10 (31.25)29.6817
2010's12 (37.50)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Topliss, JG; Yoshida, F1
Artursson, P; Luthman, K; Norinder, U; Stenberg, P1
Alvarez-Pedraglio, A; Colmenarejo, G; Lavandera, JL1
Gao, F; Lombardo, F; Obach, RS; Shalaeva, MY1
Artursson, P; Bergström, CA; Matsson, P; Nagahara, N; Norinder, U; Tavelin, S1
Bellows, DS; Clarke, ID; Diamandis, P; Dirks, PB; Graham, J; Jamieson, LG; Ling, EK; Sacher, AG; Tyers, M; Ward, RJ; Wildenhain, J1
Lombardo, F; Obach, RS; Waters, NJ1
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV1
Du-Cuny, L; Mash, EA; Meuillet, EJ; Moses, S; Powis, G; Song, Z; Zhang, S1
Choi, SS; Contrera, JF; Hastings, KL; Kruhlak, NL; Sancilio, LF; Weaver, JL; Willard, JM1
Campillo, NE; Guerra, A; Páez, JA1
Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV1
Benet, LZ; Brouwer, KL; Chu, X; Dahlin, A; Evers, R; Fischer, V; Giacomini, KM; Hillgren, KM; Hoffmaster, KA; Huang, SM; Ishikawa, T; Keppler, D; Kim, RB; Lee, CA; Niemi, M; Polli, JW; Sugiyama, Y; Swaan, PW; Tweedie, DJ; Ware, JA; Wright, SH; Yee, SW; Zamek-Gliszczynski, MJ; Zhang, L1
Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ1
Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ1
Ekins, S; Williams, AJ; Xu, JJ1
Ahlin, G; Bergström, F; Bredberg, U; Fridén, M; Hammarlund-Udenaes, M; Rehngren, M; Wan, H1
Annand, R; Gozalbes, R; Jacewicz, M; Pineda-Lucena, A; Tsaioun, K1
Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR1
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K1
Levi, R; Zavecz, JH1
Bochner, F; Sallustio, BC; Somogyi, AA1
Earley, KJ; Gunasegaram, S; Tenner, TE1
Goldie, RG; Papadimitriou, JM; Paterson, JW; Rigby, PJ; Self, HM; Spina, D1
Kaumann, AJ; Lemoine, H; Walter, M1
Kirch, W; Mutschler, E; Spahn, H2
Neuvonen, PJ; Olkkola, KT1
Mészáros, J; Szegi, J1
Satoh, H1
Block, F; Dafotakis, M1

Reviews

3 review(s) available for pindolol and cimetidine

ArticleYear
Membrane transporters in drug development.
    Nature reviews. Drug discovery, 2010, Volume: 9, Issue:3

    Topics: Animals; Computer Simulation; Decision Trees; Drug Approval; Drug Discovery; Drug Evaluation, Preclinical; Drug Interactions; Humans; Membrane Transport Proteins; Mice; Mice, Knockout; Prescription Drugs

2010
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
    Drug discovery today, 2016, Volume: 21, Issue:4

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk

2016
[Drug-induced tremor].
    Fortschritte der Neurologie-Psychiatrie, 2011, Volume: 79, Issue:10

    Topics: Adrenergic beta-2 Receptor Agonists; Adrenergic beta-Antagonists; Animals; Anticonvulsants; Antidepressive Agents; Antipsychotic Agents; Bronchodilator Agents; Cimetidine; Histamine H2 Antagonists; Humans; Immunosuppressive Agents; Lamotrigine; Lithium Compounds; Pindolol; Theophylline; Tremor; Triazines; Valproic Acid

2011

Trials

1 trial(s) available for pindolol and cimetidine

ArticleYear
Activated charcoal and syrup of ipecac in prevention of cimetidine and pindolol absorption in man after administration of metoclopramide as an antiemetic agent.
    Journal of toxicology. Clinical toxicology, 1984, Volume: 22, Issue:2

    Topics: Administration, Oral; Adsorption; Adult; Analysis of Variance; Charcoal; Cimetidine; Drug Evaluation; Drug Interactions; Female; Gastrointestinal Contents; Humans; Intestinal Absorption; Ipecac; Male; Metoclopramide; Pindolol; Random Allocation

1984

Other Studies

28 other study(ies) available for pindolol and cimetidine

ArticleYear
QSAR model for drug human oral bioavailability.
    Journal of medicinal chemistry, 2000, Jun-29, Volume: 43, Issue:13

    Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship

2000
Experimental and computational screening models for the prediction of intestinal drug absorption.
    Journal of medicinal chemistry, 2001, Jun-07, Volume: 44, Issue:12

    Topics: Biological Transport; Carbon Radioisotopes; Cell Line; Cell Membrane; Cell Membrane Permeability; Ciprofloxacin; Computational Biology; Drug Design; Foscarnet; Humans; Hydrogen Bonding; Intestinal Absorption; Intestinal Mucosa; Lactulose; Mannitol; Models, Biological; Raffinose; Surface Properties; Tritium; Verapamil

2001
Cheminformatic models to predict binding affinities to human serum albumin.
    Journal of medicinal chemistry, 2001, Dec-06, Volume: 44, Issue:25

    Topics: Adrenergic beta-Antagonists; Antidepressive Agents, Tricyclic; Chromatography, Affinity; Cyclooxygenase Inhibitors; Databases, Factual; Humans; Hydrophobic and Hydrophilic Interactions; Penicillins; Pharmaceutical Preparations; Protein Binding; Quantitative Structure-Activity Relationship; Reproducibility of Results; Serum Albumin; Steroids

2001
Prediction of human volume of distribution values for neutral and basic drugs. 2. Extended data set and leave-class-out statistics.
    Journal of medicinal chemistry, 2004, Feb-26, Volume: 47, Issue:5

    Topics: Algorithms; Blood Proteins; Half-Life; Humans; Hydrogen-Ion Concentration; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Protein Binding; Statistics as Topic; Tissue Distribution

2004
Exploring the role of different drug transport routes in permeability screening.
    Journal of medicinal chemistry, 2005, Jan-27, Volume: 48, Issue:2

    Topics: Administration, Oral; Biological Transport; Caco-2 Cells; Cell Line; Humans; Intestinal Absorption; Intestinal Mucosa; Intestine, Small; Membranes, Artificial; Models, Biological; Molecular Conformation; Monte Carlo Method; Permeability; Pharmaceutical Preparations; Pharmacokinetics

2005
Chemical genetics reveals a complex functional ground state of neural stem cells.
    Nature chemical biology, 2007, Volume: 3, Issue:5

    Topics: Animals; Cell Survival; Cells, Cultured; Mice; Molecular Structure; Neoplasms; Neurons; Pharmaceutical Preparations; Sensitivity and Specificity; Stem Cells

2007
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
    Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7

    Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding

2008
Physicochemical determinants of human renal clearance.
    Journal of medicinal chemistry, 2009, Aug-13, Volume: 52, Issue:15

    Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight

2009
Computational modeling of novel inhibitors targeting the Akt pleckstrin homology domain.
    Bioorganic & medicinal chemistry, 2009, Oct-01, Volume: 17, Issue:19

    Topics: Antineoplastic Agents; Blood Proteins; Caco-2 Cells; Cell Membrane Permeability; Computer Simulation; Drug Discovery; Drug Screening Assays, Antitumor; Humans; Models, Molecular; Phosphoproteins; Protein Binding; Protein Kinase Inhibitors; Protein Structure, Tertiary; Proto-Oncogene Proteins c-akt; Quantitative Structure-Activity Relationship

2009
Development of a phospholipidosis database and predictive quantitative structure-activity relationship (QSAR) models.
    Toxicology mechanisms and methods, 2008, Volume: 18, Issue:2-3

    Topics:

2008
Neural computational prediction of oral drug absorption based on CODES 2D descriptors.
    European journal of medicinal chemistry, 2010, Volume: 45, Issue:3

    Topics: Administration, Oral; Humans; Models, Chemical; Neural Networks, Computer; Permeability; Quantitative Structure-Activity Relationship; Technology, Pharmaceutical

2010
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination.
    Journal of medicinal chemistry, 2010, Feb-11, Volume: 53, Issue:3

    Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations

2010
Developing structure-activity relationships for the prediction of hepatotoxicity.
    Chemical research in toxicology, 2010, Jul-19, Volume: 23, Issue:7

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes

2010
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development.
    Toxicological sciences : an official journal of the Society of Toxicology, 2010, Volume: 118, Issue:2

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics

2010
A predictive ligand-based Bayesian model for human drug-induced liver injury.
    Drug metabolism and disposition: the biological fate of chemicals, 2010, Volume: 38, Issue:12

    Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands

2010
Measurement of unbound drug exposure in brain: modeling of pH partitioning explains diverging results between the brain slice and brain homogenate methods.
    Drug metabolism and disposition: the biological fate of chemicals, 2011, Volume: 39, Issue:3

    Topics: Animals; Biological Transport; Brain; Chemical Phenomena; Dialysis; Hydrogen-Ion Concentration; In Vitro Techniques; Lysosomes; Male; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Reproducibility of Results; Tissue Distribution

2011
QSAR-based permeability model for drug-like compounds.
    Bioorganic & medicinal chemistry, 2011, Apr-15, Volume: 19, Issue:8

    Topics: Caco-2 Cells; Cell Membrane Permeability; Drug Discovery; Humans; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship

2011
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions.
    Journal of medicinal chemistry, 2012, May-24, Volume: 55, Issue:10

    Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection

2012
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
    Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests

2013
Acceleration of idioventricular rhythms by histamine in guinea pig heart: mediation by H2 receptors.
    Circulation research, 1979, Volume: 44, Issue:6

    Topics: Anaphylaxis; Animals; Arrhythmias, Cardiac; Chlorpheniramine; Cimetidine; Dose-Response Relationship, Drug; Guinea Pigs; Heart Block; Heart Conduction System; Histamine; Male; Methylhistamines; Pindolol; Receptors, Histamine; Receptors, Histamine H2

1979
Stereoselective inhibition of pindolol renal clearance by cimetidine in humans.
    Clinical pharmacology and therapeutics, 1992, Volume: 51, Issue:4

    Topics: Administration, Oral; Adult; Biological Transport, Active; Cimetidine; Drug Interactions; Female; Humans; Kidney; Male; Metabolic Clearance Rate; Pindolol; Stereoisomerism

1992
Determination of beta adrenoceptor density on rabbit mononuclear leukocytes.
    Journal of pharmacological methods, 1988, Volume: 19, Issue:3

    Topics: Adrenergic beta-Agonists; Animals; Atropine; Cell Membrane; Cell Separation; Cimetidine; Leukocytes, Mononuclear; Male; Pindolol; Propranolol; Rabbits; Receptors, Adrenergic, beta

1988
Influence of the epithelium on responsiveness of guinea-pig isolated trachea to contractile and relaxant agonists.
    British journal of pharmacology, 1986, Volume: 87, Issue:1

    Topics: Acetylcholine; Animals; Asthma; Autoradiography; Carbachol; Cimetidine; Colforsin; Dose-Response Relationship, Drug; Epithelium; Female; Guinea Pigs; Histamine; In Vitro Techniques; Iodocyanopindolol; Isoproterenol; Kinetics; Male; Muscle Contraction; Nitroglycerin; Pindolol; Potassium; Receptors, Adrenergic, beta; Theophylline; Trachea

1986
Stimulant and blocking effects of optical isomers of pindolol on the sinoatrial node and trachea of guinea pig. Role of beta-adrenoceptor subtypes in the dissociation between blockade and stimulation.
    Naunyn-Schmiedeberg's archives of pharmacology, 1984, Volume: 327, Issue:2

    Topics: Animals; Bupranolol; Cimetidine; Female; Guinea Pigs; Heart Rate; In Vitro Techniques; Isoproterenol; Kinetics; Male; Muscle Relaxation; Muscle, Smooth; Pindolol; Receptors, Adrenergic, beta; Serotonin Antagonists; Sinoatrial Node; Stereoisomerism; Trachea

1984
The interaction between H2-receptor antagonists and beta-adrenoceptor blockers.
    British journal of clinical pharmacology, 1984, Volume: 17 Suppl 1

    Topics: Adrenergic beta-Antagonists; Atenolol; Cimetidine; Drug Interactions; Histamine H2 Antagonists; Humans; Kinetics; Metoprolol; Penbutolol; Pindolol; Propranolol; Ranitidine

1984
Action of dimethindene on the electrophysiological and mechanical properties of atrial and ventricular myocardium of guinea-pig.
    European journal of pharmacology, 1983, Dec-09, Volume: 96, Issue:1-2

    Topics: Action Potentials; Animals; Cimetidine; Dimethindene; Electrophysiology; Guinea Pigs; In Vitro Techniques; Muscles; Myocardial Contraction; Papillary Muscles; Phentolamine; Pindolol; Pyrilamine; Stimulation, Chemical

1983
The interaction of cimetidine with metoprolol, atenolol, propranolol, pindolol and penbutolol.
    British journal of clinical pharmacology, 1983, Volume: 15, Issue:4

    Topics: Atenolol; Biological Availability; Cimetidine; Drug Interactions; Guanidines; Humans; Metoprolol; Penbutolol; Pindolol; Propanolamines; Propranolol

1983
Modulation of the automaticity by histamine and cimetidine in rabbit sino-atrial node cells.
    General pharmacology, 1993, Volume: 24, Issue:5

    Topics: Action Potentials; Animals; Arrhythmias, Cardiac; Cell Membrane; Cimetidine; Electrophysiology; Heart Rate; Histamine; In Vitro Techniques; Ion Channels; Microelectrodes; Pindolol; Rabbits; Sinoatrial Node

1993