pinafide and mitonafide

pinafide has been researched along with mitonafide* in 3 studies

Other Studies

3 other study(ies) available for pinafide and mitonafide

ArticleYear
Naphthalimides Selectively Inhibit the Activity of Bacterial, Replicative DNA Ligases and Display Bactericidal Effects against Tubercle Bacilli.
    Molecules (Basel, Switzerland), 2017, Jan-17, Volume: 22, Issue:1

    The DNA ligases, enzymes that seal breaks in the backbones of DNA, are essential for all organisms, however bacterial ligases essential for DNA replication use β-nicotinamide adenine dinucleotide as their co-factor, whereas those that are essential in eukaryotes and viruses use adenosine-5'-triphosphate. This fact leads to the conclusion that NAD⁺-dependent DNA ligases in bacteria could be targeted by their co-factor specific inhibitors. The development of novel alternative medical strategies, including new drugs, are a top priority focus areas for tuberculosis research due to an increase in the number of multi-drug resistant as well as totally drug resistant tubercle bacilli strains. Here, through the use of a virtual high-throughput screen and manual inspection of the top 200 records, 23 compounds were selected for in vitro studies. The selected compounds were evaluated in respect to their

    Topics: Antitubercular Agents; Bacterial Proteins; DNA Ligases; Enzyme Inhibitors; High-Throughput Screening Assays; Isoquinolines; Molecular Docking Simulation; Mycobacterium tuberculosis; NAD; Naphthalimides

2017
[Antineoplastic drugs used as fluorochromes].
    Revista espanola de oncologia, 1982, Volume: 29, Issue:3

    Several synthetic imide derivatives of naphthalic acid that bind to DNA and have anti-neoplastic properties are studied here in relation to the fluorescence they produce in the chromatin of chicken nucleated red blood cells.

    Topics: Adenine; Animals; Antineoplastic Agents; Chemical Phenomena; Chemistry; Chickens; DNA; Fluorescent Dyes; Imides; Isoquinolines; Naphthalimides; Organophosphonates

1982
Synthesis and mode(s) of action of a new series of imide derivatives of 3-nitro-1,8 naphthalic acid.
    Cancer chemotherapy and pharmacology, 1980, Volume: 4, Issue:1

    Four new imide derivatives of 3-nitro-1,8-naphthalic acid have been synthesised. The compounds show strong cytostatic activity against both HeLa and KB cells and are moderately toxic towards both mice and rats (LD50 above 4 mg/kg IP). Two of the most active compounds, M-4212 and M-12210, prevented the development of mouse Ehrlich ascites and rat Yoshida carcinoma. All these drugs block cell growth by inhibiting the synthesis of both DNA and RNA. In particular, both M-4212 and M-12210 raise the melting point of double-stranded DNA.

    Topics: Animals; Antineoplastic Agents; Carcinoma, Ehrlich Tumor; Cell Survival; DNA Replication; HeLa Cells; Humans; Imides; Isoquinolines; Lethal Dose 50; Mice; Naphthalimides; Neoplasm Proteins; Nitro Compounds; Pyrrolidines; Rats; RNA; Spectrophotometry, Infrared

1980