pinafide has been researched along with mitonafide* in 3 studies
3 other study(ies) available for pinafide and mitonafide
| Article | Year |
|---|---|
Naphthalimides Selectively Inhibit the Activity of Bacterial, Replicative DNA Ligases and Display Bactericidal Effects against Tubercle Bacilli.
The DNA ligases, enzymes that seal breaks in the backbones of DNA, are essential for all organisms, however bacterial ligases essential for DNA replication use β-nicotinamide adenine dinucleotide as their co-factor, whereas those that are essential in eukaryotes and viruses use adenosine-5'-triphosphate. This fact leads to the conclusion that NAD⁺-dependent DNA ligases in bacteria could be targeted by their co-factor specific inhibitors. The development of novel alternative medical strategies, including new drugs, are a top priority focus areas for tuberculosis research due to an increase in the number of multi-drug resistant as well as totally drug resistant tubercle bacilli strains. Here, through the use of a virtual high-throughput screen and manual inspection of the top 200 records, 23 compounds were selected for in vitro studies. The selected compounds were evaluated in respect to their Topics: Antitubercular Agents; Bacterial Proteins; DNA Ligases; Enzyme Inhibitors; High-Throughput Screening Assays; Isoquinolines; Molecular Docking Simulation; Mycobacterium tuberculosis; NAD; Naphthalimides | 2017 |
[Antineoplastic drugs used as fluorochromes].
Several synthetic imide derivatives of naphthalic acid that bind to DNA and have anti-neoplastic properties are studied here in relation to the fluorescence they produce in the chromatin of chicken nucleated red blood cells. Topics: Adenine; Animals; Antineoplastic Agents; Chemical Phenomena; Chemistry; Chickens; DNA; Fluorescent Dyes; Imides; Isoquinolines; Naphthalimides; Organophosphonates | 1982 |
Synthesis and mode(s) of action of a new series of imide derivatives of 3-nitro-1,8 naphthalic acid.
Four new imide derivatives of 3-nitro-1,8-naphthalic acid have been synthesised. The compounds show strong cytostatic activity against both HeLa and KB cells and are moderately toxic towards both mice and rats (LD50 above 4 mg/kg IP). Two of the most active compounds, M-4212 and M-12210, prevented the development of mouse Ehrlich ascites and rat Yoshida carcinoma. All these drugs block cell growth by inhibiting the synthesis of both DNA and RNA. In particular, both M-4212 and M-12210 raise the melting point of double-stranded DNA. Topics: Animals; Antineoplastic Agents; Carcinoma, Ehrlich Tumor; Cell Survival; DNA Replication; HeLa Cells; Humans; Imides; Isoquinolines; Lethal Dose 50; Mice; Naphthalimides; Neoplasm Proteins; Nitro Compounds; Pyrrolidines; Rats; RNA; Spectrophotometry, Infrared | 1980 |