pinacidil pyridine n-oxide has been researched along with pinacidil in 10 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 8 (80.00) | 18.7374 |
| 1990's | 2 (20.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ebisu, H; Eda, M; Fukaya, C; Gohda, M; Hihara, M; Matzno, S; Nakamura, N; Okada, T; Sakashita, H; Takemoto, T | 1 |
| Bray, KM; Newgreen, DT; Southerton, JS; Taylor, SG; Weston, AH | 1 |
| DeSante, KA; Goldberg, MR; Rockhold, FW; Thompson, WL | 1 |
| Al-Waiz, M; Ayesh, R; Idle, JR; McBurney, A; Mitchell, SC; Smith, RL; Ward, JW | 1 |
| Henry, JA; McBurney, A; Ward, JW | 1 |
| DeLong, AF; DeSante, KA; Henry, DP; Nell, G; Oldham, SW | 1 |
| Farid, KZ; Hamilton, M; Henry, DP | 1 |
| Avant, GR; Hamilton, M; Patel, J; Shaheen, O; Wood, AJ | 1 |
| Ainsworth, S; Farrow, PR; McBurney, A; Ward, JW | 1 |
| Bellissant, E; Chau, NP; Giudicelli, JF; Thuillez, C | 1 |
1 trial(s) available for pinacidil pyridine n-oxide and pinacidil
| Article | Year |
|---|---|
Pharmacokinetic-pharmacodynamic modeling between pinacidil or pinacidil-N-oxide plasma levels and systemic and regional hemodynamic effects in healthy volunteers.
Topics: Adult; Cross-Over Studies; Double-Blind Method; Guanidines; Hemodynamics; Humans; Male; Models, Biological; Models, Statistical; Pinacidil; Vasodilator Agents | 1994 |
9 other study(ies) available for pinacidil pyridine n-oxide and pinacidil
| Article | Year |
|---|---|
Novel potassium channel openers: synthesis and pharmacological evaluation of new N-(substituted-3-pyridyl)-N'-alkylthioureas and related compounds.
Topics: 4-Aminopyridine; Amifampridine; Animals; Antihypertensive Agents; Biomechanical Phenomena; Glyburide; Guanidines; Hypertension; Male; Molecular Structure; Norbornanes; Pinacidil; Portal Vein; Potassium Channels; Rats; Rats, Inbred SHR; Rats, Wistar; Structure-Activity Relationship | 1994 |
The mode of action of pinacidil and its analogs P1060 and P1368: results of studies in rat blood vessels.
Topics: Animals; Aorta, Thoracic; Electrophysiology; Guanidines; In Vitro Techniques; Male; Membrane Potentials; Microelectrodes; Muscle Contraction; Muscle, Smooth, Vascular; Pinacidil; Portal Vein; Rats; Rats, Inbred Strains; Rubidium Radioisotopes; Vasodilator Agents | 1988 |
Clinical pharmacokinetics of pinacidil, a potassium channel opener, in hypertension.
Topics: Adult; Age Factors; Antihypertensive Agents; Biological Availability; Creatinine; Female; Guanidines; Heart Rate; Humans; Hypertension; Male; Middle Aged; Pinacidil; Potassium Channels | 1989 |
Variable metabolism of pinacidil: lack of correlation with the debrisoquine and trimethylamine C- and N-oxidative polymorphisms.
Topics: Adult; Debrisoquin; Female; Guanidines; Humans; Isoquinolines; Male; Methylamines; Middle Aged; Oxidation-Reduction; Phenotype; Pinacidil; Vasodilator Agents | 1989 |
Accumulation of pinacidil N-oxide during chronic treatment with pinacidil.
Topics: Adult; Blood Pressure; Guanidines; Heart Rate; Humans; Middle Aged; Pinacidil | 1988 |
Disposition of [14C]pinacidil in humans.
Topics: Adult; Biotransformation; Guanidines; Half-Life; Humans; Male; Middle Aged; Pinacidil; Protein Binding | 1988 |
Liquid chromatographic determination of pinacidil, a new antihypertensive drug, and its major metabolite, pinacidil N-oxide, in plasma.
Topics: Antihypertensive Agents; Chromatography, Liquid; Drug Stability; Guanidines; Humans; Indicators and Reagents; Kinetics; Male; Pinacidil; Spectrophotometry, Ultraviolet | 1986 |
Effect of cirrhosis and debrisoquin phenotype on the disposition and effects of pinacidil.
Topics: Adult; Blood Pressure; Debrisoquin; Drug Interactions; Guanidines; Humans; Isoquinolines; Kinetics; Liver; Liver Cirrhosis; Male; Metabolic Clearance Rate; Middle Aged; Phenotype; Pinacidil; Pulse | 1986 |
Serum concentrations and urinary excretion of pinacidil and its major metabolite, pinacidil pyridine-N-oxide following i.v. and oral administration in healthy volunteers.
Topics: Administration, Oral; Adult; Antihypertensive Agents; Guanidines; Half-Life; Humans; Injections, Intravenous; Pinacidil | 1985 |