pinacidil has been researched along with pyrroles in 135 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 20 (14.81) | 18.7374 |
| 1990's | 115 (85.19) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Fang, D; Wu, Y | 1 |
| Braida, C; Holzmann, S; Kukovetz, WR; Pöch, G | 1 |
| Cook, D; Stockbridge, N; Vollrath, B; Weir, B; Zhang, H | 1 |
| Edwards, G; Henshaw, M; Miller, M; Weston, AH | 1 |
| Berry, JL; Foster, RW; Small, RC | 1 |
| Armstrong, JM; Barras, M; Hicks, PE; Lawson, K; Martin, DJ; Zazzi-Sudriez, E | 1 |
| Akiba, Y; Matsumoto, H; Nakano, H; Onodera, S; Osanai, S; Tobise, K | 1 |
| Kau, ST; Li, JH; Zografos, P | 1 |
| Kamijo, T; Kido, H; Miwa, A; Nakamura, F; Sugimoto, T; Tomaru, T; Uchida, Y | 1 |
| Ashford, ML; Boden, PR; Sellers, AJ | 1 |
| Duty, S; Weston, AH | 1 |
| Berdeaux, A; Dubois-Randé, JL; Giudicelli, JF; Hittinger, L; la Rochelle, CD; Richard, V; Roupie, E | 1 |
| Kato, H; Shimada, F; Takata, Y | 1 |
| Li, YQ; Triggle, CR; Wyse, DG | 1 |
| Hong, KW; Lee, WS; Rhim, BY | 1 |
| Lau, WM | 1 |
| McPherson, GA; Stork, AP | 1 |
| Andersson, KE | 1 |
| Hamilton, TC; Longman, SD | 1 |
| Zucker, JR | 1 |
| Bishop, BE; Doggrell, SA | 1 |
| Antoine, MH; Herchuelz, A; Lebrun, P | 1 |
| Arch, JR; Bond, J; Buckle, DR; Shaw, DJ; Taylor, JF; Taylor, SG; Ward, JS | 1 |
| Horacek, J; Lefebvre, RA | 1 |
| Colatsky, TJ; Cullinan, CA; Follmer, CH; Lodge, NJ | 1 |
| Bang, L; Nielsen-Kudsk, JE | 1 |
| Angel, I; Bidet, S | 1 |
| Fukushima, H; Izawa, T; Kashiwabara, T; Nakajima, S; Nishikori, K | 1 |
| Fish, FA; Prakash, C; Roden, DM | 1 |
| Busse, R; Lückhoff, A | 1 |
| Charette, L; Garcia, ML; Jones, TR; Kaczorowski, GJ | 1 |
| Erne, P; Hermsmeyer, K | 1 |
| Hood, JS; Kadowitz, PJ; McMahon, TJ | 1 |
| Berdeaux, A; Giudicelli, JF; Richer, C | 1 |
| Higuera, TR; Kadowitz, PJ; Kvamme, P; Minkes, RK; Nossaman, BD | 1 |
| Satoh, K; Taira, N; Yamada, H | 1 |
| Ksoll, E; Mackert, JR; Parsons, AA; Schilling, L; Wahl, M | 1 |
| Goto, S; Kitagaki, K; Koda, A; Nagai, H; Suda, H | 1 |
| Kurachi, Y; Machulda, MM; Shen, WK; Tung, RT | 1 |
| Stockbridge, N; Weir, B; Zhang, H | 2 |
| Halpern, W; McCarron, JG; Nelson, MT; Quayle, JM | 1 |
| Honoré, E; Lazdunski, M | 1 |
| Haeusler, G | 1 |
| Bang, L; Brønsgaard, AM; Nielsen-Kudsk, JE | 1 |
| Asano, M; Masuzawa, K; Matsuda, T | 1 |
| Angus, JA; McPherson, GA | 1 |
| Antoine, MH; Berkenboom, G; Fang, ZY; Fontaine, J; Herchuelz, A; Hermann, M; Lebrun, P | 1 |
| Downing, SJ; Hollingsworth, M; Minshall, E; Piper, I; Sadraei, H | 1 |
| Colatsky, T; Follmer, C; Parsons, R; Spinelli, W | 1 |
| Taira, N; Teshigawara, T; Yanagisawa, T | 1 |
| Satoh, E; Taira, N; Yanagisawa, T | 1 |
| Asano, M; Imaizumi, Y; Masuzawa, K; Matsuda, T; Watanabe, M | 1 |
| MacLeod, KM; Ray, A | 1 |
| Berdeaux, A; Giudicelli, JF; la Rochelle, CD | 1 |
| Baeyens, JM; Barrios, M; Del Pozo, E | 1 |
| Neumcke, B; Weik, R | 1 |
| Dzwonczyk, S; Grover, GJ; Parham, CS; Sleph, PG | 1 |
| Andersson, KE; Andersson, PO; Fovaeus, M; Malmgren, A; Sjögren, C | 1 |
| Andersson, KE; Fovaeus, M; Hedlund, H; Holmquist, F | 1 |
| Baumlin, Y; Cook, NS; Hof, RP; Pally, C; Quast, U | 1 |
| Clapham, JC; Hamilton, TC; Longman, SD; Wilson, C | 1 |
| Gotanda, K; Satoh, K; Taira, N; Yokoyama, H | 1 |
| Wilson, C | 1 |
| Brayden, JE; Davies, NW; Huang, Y; Nelson, MT; Quayle, JM; Standen, NB | 1 |
| Sanguinetti, MC; Siegl, PK; Wolleben, CD | 1 |
| Conder, ML; Grover, GJ; Henry, DE; McCullough, JR; Sleph, PG | 1 |
| Cavero, I; Courteix, J; Escande, D; Laville, M; Le Guern, S; Thuringer, D | 1 |
| Hollingsworth, M; Piper, I | 1 |
| Eltze, M | 1 |
| Garrino, MG; Henquin, JC; Plant, TD | 2 |
| Cooper, SM; Wilson, C | 1 |
| Weston, AH | 1 |
| Clapham, JC; Longman, SD | 1 |
| Grafe, P; Lehmann-Horn, F; Quasthoff, S; Spuler, A | 1 |
| Andersson, KE; Andersson, PO; Malmgren, A; Sjögren, C | 1 |
| Coldwell, MC; Cooper, SM; Hamilton, TC; Howlett, DR; Wilson, C | 1 |
| Hashimoto, H; Taira, N; Yanagisawa, T | 1 |
| Akbarali, HI; Bieger, D; Ohia, SE; Triggle, CR | 1 |
| de Tullio, P; Delarge, J; Dupont, L; Masereel, B; Pirotte, B | 1 |
| Satoh, H | 2 |
| Ishimura, Y; Katoh, I; Masuda, Y; Oka, M; Yoshizumi, M | 1 |
| Mellemkjaer, S; Nielsen-Kudsk, JE; Thirstrup, S | 1 |
| Attolini, L; Bruguerolle, B; Gantenbein, M | 1 |
| Dave, KC; Goyal, RK; Mehta, AA | 1 |
| Donatucci, CF; Hsu, GL; Lue, TF; Nunes, L; Tanagho, EA; Trigo-Rocha, F | 1 |
| D'Alonzo, AJ; Darbenzio, RB; Hess, TA; Sewter, JC | 1 |
| Ogbaghebriel, A; Shrier, A | 1 |
| Bakonyi, A; Horváth, EJ | 1 |
| Cai, B; deBoisblanc, B; Gillott, D; Goharderakhshan, R; Greenberg, SS; Hao, Q; Hyman, A; Lippton, H; Summer, WR | 1 |
| Link, H; Mix, E; Olsson, T; Zhu, J | 1 |
| Parsons, AA; Schilling, L; Wahl, M | 1 |
| Atwal, KS | 1 |
| Grover, GJ | 2 |
| Cook, D; Zhang, H | 1 |
| Doggrell, SA | 1 |
| D'Alonzo, AJ; Darbenzio, RB; Grover, GJ; Hess, TA; Sewter, JC; Sleph, PG | 1 |
| Buchanan, LV; Cimini, MG; Gibson, JK; Khan, SA; Meisheri, KD; Norman, NR; Shebuski, RJ; Toombs, CF | 1 |
| Kau, S; Levin, R; Li, J; Stetz, S; Trivedi, S | 1 |
| Christensen, H; Drottning, P; Storstein, L | 1 |
| Griffith, TM; Randall, MD; Ujiie, H | 1 |
| Fabiani, ME; Story, DF | 2 |
| Clapham, JC; Hamilton, TC; Trail, BK | 1 |
| Carmint, WJ; Colatsky, TJ; Fenichel, RL; Patelunas-Hoffman, DM | 1 |
| Iwamoto, T; Morita, T; Nishimura, N; Sukamoto, T | 1 |
| Cavero, I; Premmereur, J | 1 |
| Kamouchi, M; Kitamura, K | 1 |
| Advenier, C; Dumas, JP; Dumas, M; Giudicelli, JF | 1 |
| Sargent, C; Smith, MA; Weselcouch, EO; Wilde, MW | 1 |
| Ashford, ML; Khan, RN; Morrison, JJ; Smith, SK | 1 |
| Jackson, WF | 1 |
| Ducote, J; Harmon, CS; Lutz, D | 1 |
| Satoh, K | 1 |
| Nakaya, H | 1 |
| Griffith, TM; Randall, MD | 1 |
| Allard, B; Lazdunski, M | 1 |
| Bertaina, V; Heurteaux, C; Lazdunski, M; Widmann, C | 1 |
| Arch, JR; Bowring, NE; Buckle, DR; Foster, KA; Shaw, DJ; Taylor, JF; Taylor, SG | 1 |
| Gelband, GH; McCullough, JR | 1 |
| Barth, HL; Hempelmann, RG; Mehdorn, HM; Pradel, RH; Ziegler, A | 1 |
| Bolton, TB; Zhang, HL | 1 |
| Arletti, R; Benelli, A; Bertolini, A; Cavazzuti, E; Poggioli, R | 1 |
| Bányász, T; Nánási, PP; Pankucsi, C; Szigligeti, P; Varró, A | 1 |
| Kelly, E; Kumar, P; Poucher, SM; Prior, H; Russell, K; Wickenden, AD | 1 |
| French, RJ; Giles, WR; Han, X; Light, PE | 1 |
| McCulloch, AI; Randall, MD | 1 |
| Jagadish, M; Mishra, SK; Raviprakash, V; Telang, AG | 1 |
| Batra, S; Kostrzewska, A; Laudański, T | 1 |
| Babenko, A; Vassort, G | 1 |
| Baczkó, I; Leprán, I; Papp, JG | 1 |
| Matsumura, K; Mochizuki-Oda, N; Oosawa, Y; Takeuchi, Y; Watanabe, Y | 1 |
11 review(s) available for pinacidil and pyrroles
| Article | Year |
|---|---|
[Advance in pharmacology of potassium channels in cardiovascular system and their clinical use].
Topics: Benzopyrans; Cromakalim; Guanidines; Humans; Muscle, Smooth, Vascular; Myocardium; Niacinamide; Nicorandil; Pinacidil; Potassium Channels; Pyrroles; Vasodilator Agents | 1992 |
Clinical pharmacology of potassium channel openers.
Topics: Antihypertensive Agents; Benzopyrans; Cardiovascular System; Cromakalim; Guanidines; Humans; Niacinamide; Nicorandil; Pinacidil; Potassium Channels; Pyrroles; Respiratory System | 1992 |
Potassium channel activator drugs: mechanism of action, pharmacological properties, and therapeutic potential.
Topics: Animals; Antihypertensive Agents; Benzopyrans; Cardiovascular System; Central Nervous System; Clinical Trials as Topic; Cromakalim; Disease Models, Animal; Guanidines; Humans; Muscle, Smooth, Vascular; Muscles; Neurons; Niacinamide; Nicorandil; Pancreas; Pinacidil; Potassium Channels; Pyrroles; Vasodilator Agents | 1992 |
K(+)-channel openers: new antihypertensive drugs?
Topics: Antihypertensive Agents; Benzopyrans; Cromakalim; Dihydropyridines; Guanidines; Hemodynamics; Humans; Hypertension; Molecular Structure; Pinacidil; Potassium Channels; Pyrroles | 1990 |
Smooth muscle K+ channel openers; their pharmacology and clinical potential.
Topics: Animals; Benzopyrans; Cromakalim; Guanidines; Humans; Muscle, Smooth, Vascular; Pinacidil; Potassium Channels; Pyrroles; Vasodilator Agents | 1989 |
Pharmacology and structure-activity relationships for KATP modulators: tissue-selective KATP openers.
Topics: Action Potentials; Adenosine Triphosphate; Animals; Antihypertensive Agents; Benzopyrans; Cardiovascular Diseases; Cromakalim; Diazoxide; Guanidines; Guinea Pigs; Minoxidil; Muscle Relaxation; Muscle, Smooth, Vascular; Niacinamide; Nicorandil; Picolines; Pinacidil; Potassium Channels; Pyrans; Pyrroles; Radioligand Assay; Rats; Structure-Activity Relationship; Vasodilator Agents | 1994 |
Protective effects of ATP-sensitive potassium-channel openers in experimental myocardial ischemia.
Topics: Action Potentials; Adenosine Triphosphate; Animals; Benzopyrans; Cromakalim; Dihydropyridines; Disease Models, Animal; Dogs; Guanidines; Guinea Pigs; Myocardial Contraction; Myocardial Infarction; Myocardial Ischemia; Picolines; Pinacidil; Potassium Channels; Pyrans; Pyrroles; Rats; Vasodilator Agents | 1994 |
Cerebral vascular smooth muscle potassium channels and their possible role in the management of vasospasm.
Topics: Adenosine Triphosphate; Animals; Benzopyrans; Calcium; Cromakalim; Electrophysiology; Guanidines; Ischemic Attack, Transient; Muscle, Smooth, Vascular; Neuropeptides; Niacinamide; Nicorandil; Nitric Oxide; Pinacidil; Potassium Channels; Pyrroles; Vasoconstriction; Vasodilator Agents | 1994 |
[Ca-antagonist, K-channel-opener in the treatment of patients with congestive heart failure].
Topics: Animals; Benzopyrans; Calcium Channel Blockers; Cromakalim; Guanidines; Heart Failure; Hemodynamics; Humans; In Vitro Techniques; Ion Channel Gating; Niacinamide; Nicorandil; Pinacidil; Potassium Channels; Pyrroles; Vasodilator Agents | 1993 |
[Potential role of ATP-sensitive K+ channels in ischemia- and reperfusion-induced arrhythmias].
Topics: Action Potentials; Adenosine Triphosphate; Animals; Arrhythmias, Cardiac; Benzopyrans; Cromakalim; Glyburide; Guanidines; Humans; Myocardial Ischemia; Myocardial Reperfusion Injury; Myocardium; Niacinamide; Nicorandil; Pinacidil; Potassium; Potassium Channels; Pyrroles; Tolbutamide | 1993 |
Pharmacology of ATP-sensitive potassium channel (KATP) openers in models of myocardial ischemia and reperfusion.
Topics: Animals; ATP-Binding Cassette Transporters; Benzopyrans; Cromakalim; Guanidines; Humans; Ischemic Preconditioning, Myocardial; KATP Channels; Mitochondria, Heart; Models, Cardiovascular; Myocardial Ischemia; Myocardial Reperfusion; Niacinamide; Nicorandil; Picolines; Pinacidil; Potassium Channels; Potassium Channels, Inwardly Rectifying; Pyrans; Pyrroles; Rats | 1997 |
124 other study(ies) available for pinacidil and pyrroles
| Article | Year |
|---|---|
Pharmacological interaction experiments differentiate between glibenclamide-sensitive K+ channels and cyclic GMP as components of vasodilation by nicorandil.
Topics: Animals; Benzopyrans; Cattle; Coronary Vessels; Cromakalim; Cyclic GMP; Drug Interactions; Glyburide; Guanidines; In Vitro Techniques; Methylene Blue; Molsidomine; Muscle Relaxation; Niacinamide; Nicorandil; Nitroprusside; Pinacidil; Potassium Channels; Pyrroles; Sensitivity and Specificity; Vasodilator Agents | 1992 |
Vasodilatation of canine cerebral arteries by nicorandil, pinacidil and lemakalim.
Topics: Animals; Basilar Artery; Benzopyrans; Cerebral Arteries; Cromakalim; Dogs; Female; Glyburide; Guanidines; Guanylate Cyclase; In Vitro Techniques; Male; Methylene Blue; Muscle Contraction; Muscle, Smooth, Vascular; Niacinamide; Nicorandil; Pinacidil; Potassium Channels; Pyrroles; Vasodilation; Vasodilator Agents | 1992 |
Comparison of the effects of several potassium-channel openers on rat bladder and rat portal vein in vitro.
Topics: Animals; Benzopyrans; Cromakalim; Glyburide; Guanidines; In Vitro Techniques; Male; Pinacidil; Portal Vein; Potassium; Potassium Channels; Pyrroles; Rats; Rats, Sprague-Dawley; Urinary Bladder | 1991 |
Tracheal relaxation induced by potassium channel opening drugs: its antagonism by adrenergic neurone blocking agents.
Topics: Adrenergic Antagonists; Animals; Benzopyrans; Cromakalim; Dose-Response Relationship, Drug; Female; Guanidines; Guinea Pigs; In Vitro Techniques; Isoproterenol; Male; Muscle Relaxation; Parasympatholytics; Picolines; Pinacidil; Potassium Channels; Pyrans; Pyrroles; Rubidium Radioisotopes; Stereoisomerism; Theophylline; Trachea | 1992 |
Differential effects of endothelin-1 on the vasorelaxant properties of benzopyran and non-benzopyran potassium channel openers.
Topics: Animals; Aorta; Benzopyrans; Cromakalim; Cyclopentanes; Dihydropyridines; Dose-Response Relationship, Drug; Endothelins; Guanidines; Hypertension; In Vitro Techniques; Male; Muscle Relaxation; Muscle, Smooth, Vascular; Pinacidil; Potassium Channels; Pyridines; Pyrroles; Rats; Rats, Inbred SHR; Rats, Sprague-Dawley; Vasodilation; Vasodilator Agents | 1992 |
[Effect of potassium channel openers on hypoxic pulmonary vasoconstriction].
Topics: Angiotensin II; Animals; Benzopyrans; Cromakalim; Guanidines; Hypoxia; In Vitro Techniques; Pinacidil; Potassium Channels; Pulmonary Artery; Pyrroles; Rats; Rats, Sprague-Dawley; Vasoconstriction; Vasodilator Agents | 1992 |
Comparison of the in vitro effects of K+ channel modulators on detrusor and portal vein strips from guinea pigs.
Topics: Animals; Benzopyrans; Cromakalim; Dose-Response Relationship, Drug; Glyburide; Guanidines; Guinea Pigs; In Vitro Techniques; Male; Minoxidil; Muscle, Smooth; Muscle, Smooth, Vascular; Niacinamide; Nicorandil; Pinacidil; Portal Vein; Potassium Channels; Potassium Chloride; Pyrroles; Vasoconstriction; Vasodilator Agents | 1992 |
[The vasospasmolytic effects of nicorandil, cromakalim and pinacidil on 3,4-diaminopyridine-induced phasic contractions in canine coronary arteries as an experimental vasospasm model].
Topics: 4-Aminopyridine; Amifampridine; Animals; Benzopyrans; Coronary Vasospasm; Cromakalim; Disease Models, Animal; Dogs; Female; Glyburide; Guanidines; In Vitro Techniques; Ion Channel Gating; Male; Methylene Blue; Niacinamide; Nicorandil; Pinacidil; Potassium Channels; Pyrroles; Vasodilator Agents | 1992 |
Lack of effect of potassium channel openers on ATP-modulated potassium channels recorded from rat ventromedial hypothalamic neurones.
Topics: Adenosine Triphosphate; Animals; Benzopyrans; Calcium; Cromakalim; Diazoxide; Guanidines; Hypothalamus, Middle; In Vitro Techniques; Male; Membrane Potentials; Minoxidil; Neurons; Pinacidil; Potassium Channels; Pyrroles; Rats; Rats, Sprague-Dawley; Vasodilator Agents | 1992 |
Characteristics of the contractile response of rabbit aorta produced by cromakalim in calcium-free solution.
Topics: Animals; Aorta; Benzopyrans; Calcium; Colforsin; Cromakalim; Guanidines; Male; Microelectrodes; Minoxidil; Muscle Contraction; Muscle, Smooth, Vascular; Nifedipine; Nitroglycerin; Pinacidil; Potassium; Potassium Channels; Pyridines; Pyrroles; Rabbits; Vasoconstriction | 1992 |
Potassium channel openers dilate large epicardial coronary arteries in conscious dogs by an indirect, endothelium-dependent mechanism.
Topics: Acetylcholine; Animals; Benzopyrans; Coronary Vessels; Cromakalim; Dogs; Endothelium, Vascular; Guanidines; In Vitro Techniques; Nitroglycerin; Pinacidil; Potassium Channels; Pyrroles; Vasodilation | 1992 |
Differential effects of diazoxide, cromakalim and pinacidil on adrenergic neurotransmission and 86Rb+ efflux in rat brain cortical slices.
Topics: Animals; Benzopyrans; Cerebral Cortex; Cocaine; Cromakalim; Diazoxide; Electric Stimulation; Glyburide; Guanidines; Hydrocortisone; In Vitro Techniques; Male; Norepinephrine; Pinacidil; Potassium Channels; Pyrroles; Rats; Rats, Wistar; Rubidium Radioisotopes | 1992 |
Comparative effects of the K+ channel openers, pinacidil and cromakalim on vascular tone: sensitivity to glyburide and calcium.
Topics: Animals; Benzopyrans; Calcium; Cromakalim; Female; Glyburide; Guanidines; Humans; In Vitro Techniques; Isometric Contraction; Muscle Tonus; Muscle, Smooth, Vascular; Pinacidil; Potassium Channels; Pregnancy; Pyrroles; Rats; Rats, Inbred Strains; Ryanodine; Vasodilator Agents | 1992 |
Characterization of the vasodilatation by the K+ channel openers: cromakalim and pinacidil.
Topics: Animals; Benzopyrans; Cromakalim; Dogs; Guanidines; In Vitro Techniques; Pinacidil; Potassium Channels; Pyrroles; Vasodilation; Vasodilator Agents | 1992 |
Effects of potassium channel blockers on the negative inotropic responses induced by cromakalim and pinacidil in guinea pig atrium.
Topics: Adenosine Triphosphate; Animals; Antihypertensive Agents; Benzopyrans; Cromakalim; Depression, Chemical; Female; Glyburide; Guanidines; Guinea Pigs; Heart Atria; Myocardial Contraction; Pinacidil; Potassium Channels; Pyrroles; Stereoisomerism; Tacrine | 1992 |
The resistance of some rat cerebral arteries to the vasorelaxant effect of cromakalim and other K+ channel openers.
Topics: Acetylcholine; Animals; Antihypertensive Agents; Benzopyrans; Cerebellum; Cerebral Arteries; Cromakalim; Guanidines; Guinea Pigs; Niacinamide; Nicorandil; Nitric Oxide; Nitroglycerin; Pinacidil; Potassium Channels; Pyrroles; Rabbits; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Vascular Resistance; Vasodilator Agents | 1992 |
ATP-sensitive potassium channel agonists do not alter MAC for isoflurane in rats.
Topics: Animals; Benzopyrans; Cell Membrane; Cromakalim; Drug Interactions; Guanidines; Injections, Intraventricular; Isoflurane; Male; Pinacidil; Potassium Channels; Pulmonary Alveoli; Pyrroles; Rats; Rats, Inbred Strains; Vasodilator Agents | 1992 |
Effects of potassium channel openers and calcium channel blockers on the force responses of the electrically driven rat right ventricle strip.
Topics: Animals; Benzopyrans; Calcium Channel Blockers; Cromakalim; Electric Stimulation; Guanidines; In Vitro Techniques; Isoproterenol; Male; Myocardial Contraction; Pinacidil; Potassium Channels; Pyrroles; Rats; Rats, Inbred Strains; Ventricular Function, Right | 1992 |
Anoxia and glucose-sensitive 86Rb outflow from rat portal vein.
Topics: Adenosine Triphosphate; Animals; Benzopyrans; Cromakalim; Diazoxide; Glucose; Guanidines; Hypoxia; Permeability; Pinacidil; Portal Vein; Potassium; Potassium Channels; Pyrroles; Rats; Rats, Inbred Strains; Rubidium Radioisotopes | 1992 |
The inhibitory effects of cromakalim and its active enantiomer BRL 38227 against various agonists in guinea pig and human airways: comparison with pinacidil and verapamil.
Topics: Animals; Benzopyrans; Bronchi; Bronchial Spasm; Bronchodilator Agents; Carbachol; Cromakalim; Drug Interactions; Female; Guanidines; Guinea Pigs; Humans; Male; Muscle Contraction; Pinacidil; Potassium Channels; Pyrroles; Stereoisomerism; Trachea; Vasodilator Agents; Verapamil | 1992 |
Relaxant effects of BRL 38227 and pinacidil on the rat gastric fundus.
Topics: Animals; Benzopyrans; Cromakalim; Dose-Response Relationship, Drug; Female; Gastric Fundus; Glyburide; Guanidines; In Vitro Techniques; Male; Muscle Relaxation; Phentolamine; Pinacidil; Potassium Channels; Pyrroles; Rats; Vasodilator Agents | 1992 |
Electromechanical effects of the putative potassium channel activator celikalim (WAY-120,491) on feline atrial and ventricular muscle.
Topics: Animals; Antihypertensive Agents; Benzopyrans; Cats; Cromakalim; Electric Stimulation; Guanidines; Heart; Indoles; Muscle, Smooth, Vascular; Myocardial Contraction; Pinacidil; Potassium; Pyrroles | 1992 |
Smooth muscle relaxation and inhibition of responses to pinacidil and cromakalim induced by phentolamine in guinea-pig isolated trachea.
Topics: Animals; Benzopyrans; Carbachol; Cromakalim; Dinoprost; Female; Guanidines; Guinea Pigs; Histamine; In Vitro Techniques; Male; Muscle Contraction; Muscle Relaxation; Muscle, Smooth; Phentolamine; Pinacidil; Pyrroles; SRS-A; Trachea | 1992 |
The binding site for [3H]glibenclamide in the rat cerebral cortex does not recognize K-channel agonists or antagonists other than sulphonylureas.
Topics: Animals; Benzopyrans; Binding Sites; Calcium Channels; Cerebral Cortex; Cromakalim; Glyburide; Guanidines; In Vitro Techniques; Kinetics; Male; Membranes; Pinacidil; Potassium Channels; Pyrroles; Rats; Rats, Inbred Strains; Sulfonylurea Compounds; Vasodilator Agents | 1991 |
Characteristics of KRN2391, a novel vasodilator, compared with those of cromakalim, pinacidil and nifedipine in rat aorta.
Topics: Animals; Aorta, Thoracic; Benzopyrans; Cromakalim; Dose-Response Relationship, Drug; Guanidines; Guanylate Cyclase; Male; Muscle Relaxation; Nifedipine; Nitrogen Dioxide; Pinacidil; Potassium Channels; Pyridines; Pyrroles; Rats; Rats, Inbred Strains; Rubidium Radioisotopes; Vasodilator Agents | 1991 |
Suppression of repolarization-related arrhythmias in vitro and in vivo by low-dose potassium channel activators.
Topics: Animals; Arrhythmias, Cardiac; Benzopyrans; Cardiac Complexes, Premature; Cesium; Chlorides; Cromakalim; Dogs; Dose-Response Relationship, Drug; Drug Evaluation; Electrophysiology; Guanidines; Osmolar Concentration; Pinacidil; Potassium Channels; Pyrroles; Quinidine; Rabbits; Tachycardia, Supraventricular; Vasodilator Agents | 1990 |
Activators of potassium channels enhance calcium influx into endothelial cells as a consequence of potassium currents.
Topics: Animals; Benzopyrans; Calcium; Cells, Cultured; Cromakalim; Diuretics; Endothelium, Vascular; Guanidines; Ion Channels; Pinacidil; Potassium Channels; Pyridines; Pyrroles; Swine | 1990 |
Selective inhibition of relaxation of guinea-pig trachea by charybdotoxin, a potent Ca(++)-activated K+ channel inhibitor.
Topics: Aminophylline; Animals; Benzopyrans; Calcium; Carbachol; Charybdotoxin; Cromakalim; Dose-Response Relationship, Drug; Glyburide; Guanidines; Guinea Pigs; In Vitro Techniques; Isoproterenol; Male; Muscle Relaxation; Nitroprusside; Pinacidil; Potassium Channels; Pyrroles; Scorpion Venoms; Serotonin; Trachea | 1990 |
Modulation of intracellular calcium by potassium channel openers in vascular muscle.
Topics: Animals; Benzopyrans; Calcium; Cells, Cultured; Cromakalim; Guanidines; Muscle, Smooth, Vascular; Norepinephrine; Pinacidil; Potassium Channels; Pyrroles; Rats; Rats, Inbred WKY; Tetraethylammonium; Tetraethylammonium Compounds; Vasodilator Agents | 1991 |
Pulmonary vasodilator responses to RP 52891 are mediated by activation of a glibenclamide-sensitive K+ATP channel.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Acetylcholine; Adenosine Triphosphate; Animals; Benzopyrans; Blood Gas Analysis; Blood Pressure; Cats; Cromakalim; Female; Glyburide; Guanidines; Hydrogen-Ion Concentration; Isoproterenol; Male; Nitroprusside; Picolines; Pinacidil; Potassium Channels; Prostaglandin Endoperoxides, Synthetic; Pulmonary Circulation; Pyrans; Pyrroles; Vasodilation; Vasodilator Agents | 1991 |
[Potassium channel activators. Perspectives in the treatment of arterial hypertension].
Topics: Antihypertensive Agents; Benzopyrans; Cromakalim; Guanidines; Humans; Hypertension; Niacinamide; Nicorandil; Pinacidil; Potassium Channels; Pyrroles | 1991 |
Analysis of pulmonary and systemic vascular responses to cromakalim, an activator of K+ATP channels.
Topics: Adenosine Triphosphate; Animals; Antihypertensive Agents; Benzopyrans; Blood Circulation; Cats; Cromakalim; Endothelins; Glyburide; Guanidines; Heart Rate; Hindlimb; Myocardial Contraction; Niacinamide; Nicorandil; Pinacidil; Potassium Channels; Pulmonary Circulation; Pyrroles; Vascular Resistance; Vasodilator Agents; Ventricular Function, Right | 1991 |
Differential antagonism by glibenclamide of the relaxant effects of cromakalim, pinacidil and nicorandil on canine large coronary arteries.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Arteries; Benzopyrans; Coronary Vessels; Cromakalim; Dogs; Dose-Response Relationship, Drug; Female; Glyburide; Guanidines; Male; Methylene Blue; Muscle Contraction; Muscle, Smooth, Vascular; Niacinamide; Nicorandil; Nitroglycerin; Pinacidil; Potassium; Prostaglandin Endoperoxides, Synthetic; Pyrroles; Vasodilator Agents | 1991 |
Analysis of cromakalim-, pinacidil-, and nicorandil-induced relaxation of the 5-hydroxytryptamine precontracted rat isolated basilar artery.
Topics: Animals; Basilar Artery; Benzopyrans; Cromakalim; Drug Interactions; Glyburide; Guanidines; Male; Muscle, Smooth, Vascular; Niacinamide; Nicorandil; Pinacidil; Potassium Channels; Pyrroles; Rats; Rats, Inbred Strains; Serotonin; Serotonin Antagonists; Vasoconstriction; Vasodilation; Vasodilator Agents | 1991 |
Effect of three novel K+ channel openers, cromakalim, pinacidil and nicorandil on allergic reaction and experimental asthma.
Topics: Airway Resistance; Animals; Asthma; Benzopyrans; Bronchodilator Agents; Cromakalim; Guanidines; Guinea Pigs; In Vitro Techniques; Mice; Mice, Inbred Strains; Niacinamide; Nicorandil; Passive Cutaneous Anaphylaxis; Pinacidil; Potassium Channels; Pyrroles; Rats; Trachea; Vasculitis | 1991 |
Essential role of nucleotide diphosphates in nicorandil-mediated activation of cardiac ATP-sensitive K+ channel. A comparison with pinacidil and lemakalim.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Animals; Benzopyrans; Cromakalim; Guanidines; Myocardium; Niacinamide; Nicorandil; Phosphorylation; Pinacidil; Potassium Channels; Pyrroles; Vasodilator Agents | 1991 |
Effects of pinacidil, cromakalim, and nicorandil on potassium currents of rat basilar artery smooth muscle.
Topics: Animals; Antihypertensive Agents; Basilar Artery; Benzopyrans; Calcium; Cerebrovascular Circulation; Cromakalim; Electrophysiology; Guanidines; In Vitro Techniques; Male; Muscle, Smooth, Vascular; Niacinamide; Nicorandil; Pinacidil; Potassium Channels; Pyrroles; Rats; Rats, Inbred Strains | 1991 |
Cromakalim and pinacidil dilate small mesenteric arteries but not small cerebral arteries.
Topics: Animals; Benzopyrans; Cerebral Arteries; Cromakalim; Glyburide; Guanidines; Male; Mesenteric Arteries; Pinacidil; Potassium; Potassium Channels; Pyrroles; Rats; Rats, Inbred WKY; Vasodilation; Vasodilator Agents | 1991 |
Two different types of channels are targets for potassium channel openers in Xenopus oocytes.
Topics: Animals; Benzopyrans; Cromakalim; Electric Conductivity; Female; Glyburide; Guanidines; Oocytes; Organic Chemicals; Pinacidil; Potassium Channels; Pyrroles; Vasodilator Agents; Xenopus laevis | 1991 |
Effects of K+ channel agonists cromakalim and pinacidil on rat basilar artery smooth muscle cells are mediated by Ca(++)-activated K+ channels.
Topics: Animals; Basilar Artery; Benzopyrans; Calcium; Cells, Cultured; Cromakalim; Guanidines; Membrane Potentials; Muscle, Smooth, Vascular; Pinacidil; Potassium Channels; Pyrroles; Rats; Rats, Inbred Strains; Vasodilator Agents | 1991 |
Glibenclamide blocks the relaxant action of pinacidil and cromakalim in airway smooth muscle.
Topics: Animals; Benzopyrans; Cromakalim; Female; Glyburide; Guanidines; Guinea Pigs; Histamine; In Vitro Techniques; Male; Muscle Relaxants, Central; Muscle Relaxation; Muscle, Smooth; Pinacidil; Pyrroles; Terbutaline; Theophylline; Trachea; Verapamil | 1990 |
Evidence that pinacidil may promote the opening of ATP-sensitive K+ channels yet inhibit the opening of Ca2(+)-activated K+ channels in K(+)-contracted canine mesenteric artery.
Topics: Adenosine Triphosphate; Animals; Benzopyrans; Calcium; Cromakalim; Dogs; Female; Glyburide; Guanidines; In Vitro Techniques; Male; Mesenteric Arteries; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Nifedipine; Pinacidil; Potassium; Potassium Channels; Pyrroles; Rubidium Radioisotopes | 1990 |
Characterization of responses to cromakalim and pinacidil in smooth and cardiac muscle by use of selective antagonists.
Topics: Animals; Aorta, Thoracic; Benzopyrans; Clonidine; Coronary Vessels; Cromakalim; Dogs; Electric Stimulation; Glyburide; Guanidines; Guinea Pigs; Heart; In Vitro Techniques; Isoproterenol; Muscle Contraction; Muscle, Smooth; Muscle, Smooth, Vascular; Myocardial Contraction; Phentolamine; Pinacidil; Potassium Channels; Pyrroles; Rats | 1990 |
Hypoglycemic sulfonylureas antagonize the effects of cromakalim and pinacidil on 86Rb fluxes and contractile activity in the rat aorta.
Topics: Animals; Aorta, Thoracic; Benzopyrans; Cromakalim; Glyburide; Guanidines; Hypoglycemic Agents; In Vitro Techniques; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Nitroprusside; Parasympatholytics; Pinacidil; Potassium Channels; Pyrroles; Rats; Rats, Inbred Strains; Rubidium Radioisotopes; Sulfonylurea Compounds; Tetraethylammonium Compounds; Tolbutamide; Vasodilator Agents | 1990 |
Effects of several potassium channel openers and glibenclamide on the uterus of the rat.
Topics: Animals; Benzopyrans; Blood Pressure; Cromakalim; Female; Glyburide; Guanidines; Heart Rate; Hemodynamics; In Vitro Techniques; Oxytocin; Parasympatholytics; Picolines; Pinacidil; Potassium Channels; Potassium Chloride; Pregnancy; Pyrans; Pyrroles; Rats; Rats, Inbred Strains; Uterus; Vasodilator Agents | 1990 |
Effects of cromakalim, pinacidil and nicorandil on cardiac refractoriness and arterial pressure in open-chest dogs.
Topics: Animals; Atrioventricular Node; Benzopyrans; Blood Pressure; Cromakalim; Dogs; Dose-Response Relationship, Drug; Electrocardiography; Female; Guanidines; Heart Conduction System; Heart Rate; Male; Neural Conduction; Niacinamide; Nicorandil; Pinacidil; Potassium Channels; Pyrroles; Refractory Period, Electrophysiological | 1990 |
Cytoplasmic calcium and the relaxation of canine coronary arterial smooth muscle produced by cromakalim, pinacidil and nicorandil.
Topics: Adenosine Triphosphate; Animals; Benzopyrans; Calcium; Coronary Vessels; Cromakalim; Cytoplasm; Dogs; Female; Fluorescence; Glyburide; Guanidines; In Vitro Techniques; Male; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Niacinamide; Nicorandil; Pinacidil; Potassium Chloride; Pyrroles; Quaternary Ammonium Compounds | 1990 |
Specific antagonism by glibenclamide of negative inotropic effects of potassium channel openers in canine atrial muscle.
Topics: Animals; Benzopyrans; Carbachol; Cromakalim; Dogs; Female; Glyburide; Guanidines; Heart Atria; Male; Myocardial Contraction; Niacinamide; Nicorandil; Nifedipine; Pinacidil; Potassium Channels; Pyrroles; Vasodilator Agents | 1990 |
Comparison of effects of cromakalim and pinacidil on mechanical activity and 86Rb efflux in dog coronary arteries.
Topics: Animals; Benzopyrans; Calcium Channels; Coronary Vessels; Cromakalim; Dogs; Female; Glyburide; Guanidines; Male; Muscle, Smooth, Vascular; Pinacidil; Potassium Channels; Pyrroles; Rubidium Radioisotopes; Vasoconstriction; Vasodilator Agents | 1990 |
Adrenergic-cholinergic interactions in left atria: a study using K+ channel agonists, antagonist and pertussis toxin.
Topics: 4-Aminopyridine; Animals; Benzopyrans; Carbachol; Cromakalim; Cyclic AMP; Dogs; Female; Guanidines; Heart; Isoproterenol; Male; Myocardial Contraction; Parasympathetic Nervous System; Pertussis Toxin; Phenylephrine; Pinacidil; Potassium Channels; Pyrroles; Rabbits; Sympathetic Nervous System; Virulence Factors, Bordetella | 1990 |
Effects of cromakalim and pinacidil on large epicardial and small coronary arteries in conscious dogs.
Topics: Animals; Benzopyrans; Blood Pressure; Coronary Circulation; Coronary Vessels; Cromakalim; Dogs; Female; Guanidines; Heart Rate; Male; Nitroglycerin; Pinacidil; Pyrroles; Receptors, Adrenergic, beta; Vascular Resistance; Vasodilator Agents | 1990 |
Effects of potassium channel openers on pentylenetetrazole-induced seizures in mice.
Topics: 4-Aminopyridine; Animals; Benzopyrans; Cromakalim; Drug Antagonism; Female; Guanidines; Mice; Pentylenetetrazole; Pinacidil; Potassium Channels; Pyrroles; Seizures | 1990 |
Effects of potassium channel openers on single potassium channels in mouse skeletal muscle.
Topics: Adenosine Triphosphate; Animals; Benzopyrans; Calcium; Cromakalim; Female; Guanidines; In Vitro Techniques; Membrane Potentials; Mice; Muscles; Organ Specificity; Picolines; Pinacidil; Potassium Channels; Pyrans; Pyrroles | 1990 |
The protective effects of cromakalim and pinacidil on reperfusion function and infarct size in isolated perfused rat hearts and anesthetized dogs.
Topics: Animals; Benzopyrans; Blood Pressure; Cromakalim; Dogs; Female; Guanidines; In Vitro Techniques; L-Lactate Dehydrogenase; Male; Myocardial Infarction; Myocardial Reperfusion Injury; Pentobarbital; Pinacidil; Pyrroles; Rats; Rats, Inbred Strains; Vasodilator Agents | 1990 |
Effects of cromakalim (BRL 34915) and pinacidil on normal and hypertrophied rat detrusor in vitro.
Topics: Animals; Benzopyrans; Carbachol; Cromakalim; Dose-Response Relationship, Drug; Electric Stimulation; Female; Guanidines; Hypertrophy; In Vitro Techniques; Muscle Contraction; Pinacidil; Potassium; Pyrroles; Rats; Rats, Inbred Strains; Urinary Bladder; Vasodilator Agents | 1990 |
K(+)-channel openers for relaxation of isolated penile erectile tissue from rabbit.
Topics: Animals; Benzopyrans; Cromakalim; Electric Stimulation; Guanidines; In Vitro Techniques; Male; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Norepinephrine; Papaverine; Penile Erection; Penis; Pinacidil; Potassium; Potassium Channels; Pyrroles; Rabbits; Vasodilator Agents | 1990 |
Similarities in the mechanism of action of two new vasodilator drugs: pinacidil and BRL 34915.
Topics: Animals; Aorta, Thoracic; Benzopyrans; Blood Pressure; Cromakalim; Female; Guanidines; Guinea Pigs; In Vitro Techniques; Ion Channels; Male; Muscle, Smooth, Vascular; Pinacidil; Portal Vein; Potassium; Pyrroles; Rabbits; Rats; Vasodilation; Vasodilator Agents | 1988 |
Cromakalim, a potassium channel activator: a comparison of its cardiovascular haemodynamic profile and tissue specificity with those of pinacidil and nicorandil.
Topics: Animals; Antihypertensive Agents; Benzopyrans; Cats; Coronary Circulation; Cromakalim; Female; Guanidines; Hemodynamics; In Vitro Techniques; Male; Muscle, Smooth, Vascular; Niacinamide; Nicorandil; Organ Specificity; Papillary Muscles; Pinacidil; Portal Vein; Potassium Channels; Pyrroles; Rabbits | 1988 |
Cardiohemodynamic effects of cromakalim and pinacidil, potassium-channel openers, in the dog, special reference to venous return.
Topics: Animals; Benzopyrans; Blood Pressure; Cardiac Output; Cardiopulmonary Bypass; Carotid Sinus; Cromakalim; Dogs; Female; Guanidines; Heart; Hemodynamics; Male; Pinacidil; Potassium Channels; Pressoreceptors; Pyrroles; Vasodilator Agents; Vena Cava, Inferior; Vena Cava, Superior; Venous Pressure | 1989 |
Inhibition by sulphonylureas of vasorelaxation induced by K+ channel activators in vitro.
Topics: Animals; Antihypertensive Agents; Benzopyrans; Cromakalim; Drug Interactions; Glipizide; Glyburide; Guanidines; In Vitro Techniques; Male; Nifedipine; Norepinephrine; Pinacidil; Potassium Channels; Potassium Chloride; Pyrroles; Rabbits; Sulfonylurea Compounds; Tolbutamide; Vasodilator Agents | 1989 |
Hyperpolarizing vasodilators activate ATP-sensitive K+ channels in arterial smooth muscle.
Topics: Acetylcholine; Adenosine Triphosphate; Animals; Benzopyrans; Cerebral Arteries; Cromakalim; Diazoxide; Glyburide; Guanidines; Mesenteric Arteries; Muscle, Smooth, Vascular; Pinacidil; Potassium Channels; Pyrroles; Rabbits; Rats; Tolbutamide; Vasoactive Intestinal Peptide; Vasodilator Agents | 1989 |
Influence of ATP-sensitive potassium channel modulators on ischemia-induced fibrillation in isolated rat hearts.
Topics: Adenosine Triphosphate; Animals; Antihypertensive Agents; Arrhythmias, Cardiac; Benzopyrans; Coronary Circulation; Coronary Disease; Cromakalim; Glyburide; Guanidines; Heart; Heart Rate; In Vitro Techniques; Male; Perfusion; Pinacidil; Potassium Channels; Pyrroles; Rats; Rats, Inbred Strains; Tolbutamide; Vascular Resistance | 1989 |
Anti-ischemic effects of the potassium channel activators pinacidil and cromakalim and the reversal of these effects with the potassium channel blocker glyburide.
Topics: Animals; Antihypertensive Agents; Benzopyrans; Coronary Disease; Cromakalim; Glyburide; Guanidines; In Vitro Techniques; Male; Membrane Potentials; Pinacidil; Potassium Channels; Pyrroles; Rats; Rats, Inbred Strains | 1989 |
Potassium channel openers act through an activation of ATP-sensitive K+ channels in guinea-pig cardiac myocytes.
Topics: Adenosine Triphosphate; Animals; Benzopyrans; Cromakalim; Electrophysiology; Glyburide; Guanidines; Guinea Pigs; Heart; In Vitro Techniques; Ion Channel Gating; Muscle, Smooth, Vascular; Picolines; Pinacidil; Potassium Channels; Pyrans; Pyrroles; Subtraction Technique | 1989 |
Cromakalim, RP49356, pinacidil and minoxidil sulphate in the rat uterus and their antagonism by glibenclamide. Smooth Muscle Research Group.
Topics: Animals; Benzopyrans; Cromakalim; Female; Glyburide; Guanidines; In Vitro Techniques; Minoxidil; Parasympatholytics; Picolines; Pinacidil; Pyrans; Pyrroles; Rats; Rats, Inbred Strains; Uterine Contraction | 1989 |
Glibenclamide is a competitive antagonist of cromakalim, pinacidil and RP 49356 in guinea-pig pulmonary artery.
Topics: Animals; Benzopyrans; Cromakalim; Glyburide; Guanidines; Guinea Pigs; In Vitro Techniques; Male; Methylene Blue; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Niacinamide; Nicorandil; Picolines; Pinacidil; Potassium Channels; Potassium Chloride; Pulmonary Artery; Purinones; Pyrans; Pyrroles; Tetraethylammonium Compounds | 1989 |
Comparison of the effects of putative activators of K+ channels on pancreatic B-cell function.
Topics: Animals; Benzopyrans; Cromakalim; Diazoxide; Guanidines; In Vitro Techniques; Islets of Langerhans; Mice; Minoxidil; Niacinamide; Nicorandil; Pinacidil; Potassium Channels; Pyrroles; Vasodilator Agents | 1989 |
Effects of putative activators of K+ channels in mouse pancreatic beta-cells.
Topics: Adenosine Triphosphate; Animals; Benzopyrans; Cromakalim; Diazoxide; Electrophysiology; Female; Glucose; Guanidines; Homeostasis; In Vitro Techniques; Insulin; Insulin Secretion; Islets of Langerhans; Membrane Potentials; Mice; Minoxidil; Niacinamide; Nicorandil; Pinacidil; Potassium Channels; Pyrroles; Rubidium Radioisotopes | 1989 |
Effect of cromakalim on contractions in rabbit isolated renal artery in the presence and absence of extracellular Ca2+.
Topics: Animals; Benzopyrans; Caffeine; Calcium; Calcium Channel Blockers; Cromakalim; Guanidines; Guanylate Cyclase; Histamine; In Vitro Techniques; Lanthanum; Male; Muscle Contraction; Muscle, Smooth, Vascular; Nifedipine; Nitroprusside; Norepinephrine; Pinacidil; Pyrroles; Rabbits; Renal Artery; Vasodilator Agents | 1989 |
Haemodynamic differences between cromakalim and pinacidil: comparison with nifedipine.
Topics: Animals; Benzopyrans; Blood Pressure; Cats; Cromakalim; Guanidines; Heart Rate; Hemodynamics; Male; Nifedipine; Pinacidil; Pyrroles; Renal Circulation; Renin | 1989 |
Cromakalim, pinacidil and RP 49356 activate a tolbutamide-sensitive K+ conductance in human skeletal muscle fibres.
Topics: Benzopyrans; Cromakalim; Guanidines; Humans; In Vitro Techniques; Membrane Potentials; Muscles; Picolines; Pinacidil; Potassium Channels; Pyrans; Pyrroles; Tolbutamide; Vasodilator Agents | 1989 |
Effects of pinacidil and cromakalim (BRL 34915) on bladder function in rats with detrusor instability.
Topics: Animals; Benzopyrans; Cromakalim; Female; Guanidines; Hypertrophy; Pinacidil; Pyrroles; Rats; Rats, Inbred Strains; Reference Values; Urethral Obstruction; Urinary Bladder; Urinary Bladder Diseases | 1989 |
Comparative effects of K+ channel blockade on the vasorelaxant activity of cromakalim, pinacidil and nicorandil.
Topics: 4-Aminopyridine; Aminopyridines; Animals; Benzopyrans; Cardiovascular Agents; Cromakalim; Guanidines; In Vitro Techniques; Male; Mesenteric Arteries; Muscle Relaxation; Muscle, Smooth, Vascular; Niacinamide; Nicorandil; Pinacidil; Potassium Channels; Procaine; Pyrroles; Rabbits; Rubidium Radioisotopes; Tetraethylammonium Compounds; Vasodilator Agents | 1988 |
The negative inotropic effect of nicorandil is independent of cyclic GMP changes: a comparison with pinacidil and cromakalim in canine atrial muscle.
Topics: Animals; Anti-Arrhythmia Agents; Antihypertensive Agents; Benzopyrans; Cromakalim; Cyclic AMP; Cyclic GMP; Dogs; Female; Guanidines; In Vitro Techniques; Male; Monoamine Oxidase Inhibitors; Myocardial Contraction; Myocardium; Niacinamide; Nicorandil; Nifedipine; Pinacidil; Potassium Channels; Pyrroles; Tetraethylammonium Compounds; Vasodilator Agents | 1988 |
Similarity of relaxations evoked by BRL 34915, pinacidil and field-stimulation in rat oesophageal tunica muscularis mucosae.
Topics: Animals; Antihypertensive Agents; Benzopyrans; Cromakalim; Electric Stimulation; Esophagus; Guanidines; Guinea Pigs; In Vitro Techniques; Male; Muscle Relaxation; Muscle, Smooth; Nifedipine; Pinacidil; Potassium Channels; Pyrroles; Rats; Rubidium Radioisotopes; Tetrodotoxin | 1988 |
[Potassium channel activators: comparative structural study of pinacidil, diazoxide and cromakalim].
Topics: Antihypertensive Agents; Benzopyrans; Cromakalim; Diazoxide; Guanidines; Molecular Conformation; Molecular Structure; Pinacidil; Potassium Channels; Pyrroles | 1995 |
Effects of ATP-sensitive K+ channel openers on pacemaker activity in isolated single rabbit sino-atrial node cells.
Topics: Action Potentials; Adenosine Triphosphate; Animals; Benzopyrans; Cromakalim; Electrophysiology; Glyburide; Guanidines; Heart Rate; In Vitro Techniques; Niacinamide; Nicorandil; Pinacidil; Potassium Channels; Pyrroles; Rabbits; Sinoatrial Node; Vasodilator Agents | 1993 |
Effects of the potassium channel openers cromakalim and pinacidil on catecholamine secretion and calcium mobilization in cultured bovine adrenal chromaffin cells.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Adrenal Medulla; Animals; Barium; Benzopyrans; Bradykinin; Calcimycin; Calcium; Carbachol; Catecholamines; Cattle; Cells, Cultured; Cromakalim; Guanidines; Histamine; Pinacidil; Potassium; Potassium Channels; Pyrroles; Rubidium Radioisotopes | 1994 |
Inhibition by cromakalim, pinacidil, terbutaline, theophylline and verapamil of non-cholinergic nerve-mediated contractions of guinea-pig isolated bronchi.
Topics: Animals; Benzopyrans; Bronchi; Bronchodilator Agents; Cromakalim; Dose-Response Relationship, Drug; Guanidines; Guinea Pigs; Muscle Contraction; Muscle, Smooth; Neuromuscular Junction; Pinacidil; Potassium Channels; Pyrroles; Substance P; Synaptic Transmission; Terbutaline; Theophylline; Verapamil | 1994 |
Effect of four potassium channel agonists on bupivacaine-induced toxicity in mice.
Topics: Animals; Benzopyrans; Bupivacaine; Cromakalim; Diazoxide; Dose-Response Relationship, Drug; Guanidines; Male; Mice; Mice, Inbred Strains; Niacinamide; Nicorandil; Pinacidil; Potassium Channels; Pyrroles; Seizures | 1995 |
Involvement of K+ channels in the relaxant responses to various agonists in estrogen primed rat uterus.
Topics: Animals; Benzopyrans; Calcium; Cromakalim; Dose-Response Relationship, Drug; Epinephrine; Estrogens; Female; Guanidines; Histamine; Isoproterenol; Muscle Relaxation; Muscle, Smooth; Pinacidil; Potassium Channels; Potassium Chloride; Pyrroles; Rats; Rats, Wistar; Uterine Contraction; Uterus; Vasodilator Agents | 1995 |
The effect of intracavernous injection of potassium channel openers in monkeys and dogs.
Topics: Animals; Benzopyrans; Blood Pressure; Cromakalim; Dogs; Guanidines; Injections; Macaca nemestrina; Male; Penile Erection; Penis; Pinacidil; Potassium Channels; Pyrroles; Regional Blood Flow; Vasodilator Agents | 1995 |
Effects of intracoronary cromakalim, pinacidil, or diltiazem on cesium chloride-induced arrhythmias in anesthetized dogs under conditions of controlled coronary blood flow.
Topics: Animals; Arrhythmias, Cardiac; Benzopyrans; Blood Pressure; Cesium; Chlorides; Coronary Circulation; Cromakalim; Diltiazem; Dogs; Female; Guanidines; Male; Pinacidil; Pyrroles; Vasodilator Agents | 1993 |
Differential responsiveness of atrial and ventricular myocytes to potassium channel openers.
Topics: Action Potentials; Animals; Antihypertensive Agents; Benzopyrans; Cells, Cultured; Cromakalim; Guanidines; Guinea Pigs; Heart Atria; Heart Ventricles; Patch-Clamp Techniques; Pinacidil; Potassium Channels; Pyrroles; Rabbits; Vasodilator Agents | 1995 |
Demonstration of the potassium channel opening activity of GYKI-12743 by 86Rb+ efflux studies.
Topics: Animals; Antihypertensive Agents; Arteries; Benzopyrans; Cromakalim; Dioxanes; Dose-Response Relationship, Drug; Ear; Guanidines; Ion Channel Gating; Pinacidil; Potassium Channels; Pyridazines; Pyrroles; Rabbits; Rubidium Radioisotopes | 1994 |
Differential effects of pinacidil and cromakalim on vascular relaxation and sympathetic neurotransmission.
Topics: Animals; Benzopyrans; Cattle; Cromakalim; Dogs; Electric Stimulation; Female; Guanidines; In Vitro Techniques; Male; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Norepinephrine; Pinacidil; Potassium Chloride; Pyrroles; Sympathetic Nervous System; Synaptic Transmission; Vasodilator Agents | 1994 |
Influence of K+ channel openers on interferon-gamma dependent immune response in experimental allergic neuritis (EAN).
Topics: Animals; Benzopyrans; Cromakalim; Diazoxide; Guanidines; Interferon-gamma; Ion Channel Gating; Lymph Nodes; Lymphocyte Activation; Neuritis, Autoimmune, Experimental; Pinacidil; Potassium Channels; Pyrroles; Rats; Rats, Inbred Lew | 1994 |
Dilating effect of perivascularly applied potassium channel openers cromakalim and pinacidil in rat and cat pial arteries in situ.
Topics: Animals; Benzopyrans; Cats; Cerebral Arteries; Cromakalim; Female; Glyburide; Guanidines; Ion Channel Gating; Male; Pinacidil; Potassium Channels; Pyrroles; Rats; Rats, Sprague-Dawley; Vasodilator Agents | 1994 |
Negative inotropic effect of pinacidil on the rat left atria.
Topics: Animals; Benzopyrans; Cromakalim; Depression, Chemical; Electric Stimulation; Guanidines; Heart Atria; In Vitro Techniques; Male; Myocardial Contraction; Pinacidil; Potassium Channels; Pyrroles; Rats; Rats, Wistar; Vasodilator Agents | 1993 |
Effect of potassium on the action of the KATP modulators cromakalim, pinacidil, or glibenclamide on arrhythmias in isolated perfused rat heart subjected to regional ischaemia.
Topics: Animals; Arrhythmias, Cardiac; Benzopyrans; Cromakalim; Glyburide; Guanidines; Heart; Heart Rate; Myocardial Ischemia; Myocardial Reperfusion Injury; Perfusion; Pinacidil; Potassium; Pyrroles; Rats; Rats, Sprague-Dawley; Vasodilator Agents | 1994 |
Comparative effects of the potassium channel openers cromakalim and pinacidil and the cromakalim analog U-89232 on isolated vascular and cardiac tissue.
Topics: Animals; Benzopyrans; Cromakalim; Dose-Response Relationship, Drug; Female; Glyburide; Guanidines; Male; Muscle Relaxation; Muscle, Smooth, Vascular; Myocardial Contraction; Pinacidil; Potassium Channels; Pyrroles; Rabbits; Vasodilator Agents | 1994 |
Effect of cromakalim and pinacidil on 86Rb efflux from guinea pig urinary bladder smooth muscle.
Topics: Adenosine Triphosphate; Animals; Benzopyrans; Cromakalim; Dose-Response Relationship, Drug; Guanidines; Guinea Pigs; Male; Membrane Potentials; Muscle, Smooth; Pinacidil; Potassium Channels; Pyridines; Pyrroles; Rubidium Radioisotopes; Stereoisomerism; Urinary Bladder; Vasodilator Agents | 1994 |
[Potassium channel openers. A new possible therapeutic principle in several diseases].
Topics: Antihypertensive Agents; Benzopyrans; Bronchodilator Agents; Cromakalim; Guanidines; Humans; Minoxidil; Niacinamide; Nicorandil; Pinacidil; Potassium Channels; Pyrroles; Vasodilator Agents | 1994 |
Modulation of vasodilatation to levcromakalim by adenosine analogues in the rabbit ear: an explanation for hypoxic augmentation.
Topics: Adenosine; Animals; Arginine; Benzopyrans; Blood Pressure; Cromakalim; Drug Synergism; Ear, External; Guanidines; Hypoxia; In Vitro Techniques; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitroprusside; Pinacidil; Pyrroles; Rabbits; Regional Blood Flow; Vasodilation; Vasodilator Agents; Xanthines | 1994 |
Prejunctional effects of cromakalim, nicorandil and pinacidil on noradrenergic transmission in rat isolated mesenteric artery.
Topics: Animals; Benzopyrans; Calcium; Cromakalim; Desipramine; Electric Stimulation; Extracellular Space; Female; Guanidines; In Vitro Techniques; Male; Mesenteric Arteries; Neuromuscular Junction; Niacinamide; Nicorandil; Norepinephrine; Pargyline; Phentolamine; Pinacidil; Pyrroles; Rats; Rats, Sprague-Dawley; Sympathetic Nervous System; Synaptic Transmission; Vasodilator Agents | 1994 |
K+ channel activators, acute glucose tolerance and glibenclamide-induced hypoglycaemia in the hypertensive rat.
Topics: Administration, Oral; Animals; Antihypertensive Agents; Benzopyrans; Blood Glucose; Blood Pressure; Cromakalim; Diazoxide; Dose-Response Relationship, Drug; Glucose Tolerance Test; Glyburide; Guanidines; Hypertension; Hypoglycemia; Pinacidil; Potassium Channels; Pyrroles; Rats; Rats, Inbred SHR | 1994 |
Analysis of the potassium channel openers celikalim, pinacidil and cromakalim in platelet models of thrombosis.
Topics: Animals; Antihypertensive Agents; Benzopyrans; Blood Coagulation; Cromakalim; Disease Models, Animal; Evaluation Studies as Topic; Guanidines; Humans; Indoles; Male; Molecular Structure; Pinacidil; Platelet Aggregation Inhibitors; Potassium Channels; Pyrroles; Rabbits; Stereoisomerism; Thrombosis | 1994 |
Differential vasorelaxant effects of K(+)-channel openers and Ca(2+)-channel blockers on canine isolated arteries.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Arteries; Benzopyrans; Calcium Channel Blockers; Cromakalim; Dogs; Female; Guanidines; In Vitro Techniques; Male; Muscle, Smooth, Vascular; Pinacidil; Piperazines; Potassium Channels; Prostaglandin Endoperoxides, Synthetic; Pyrroles; Vasoconstrictor Agents; Vasodilation; Vasodilator Agents; Verapamil | 1993 |
ATP sensitive potassium channel openers are of potential benefit in ischaemic heart disease.
Topics: Benzopyrans; Cromakalim; Dihydropyridines; Guanidines; Humans; Myocardial Ischemia; Myocardium; Niacinamide; Nicorandil; Picolines; Pinacidil; Potassium Channels; Pyrans; Pyrroles; Sodium-Potassium-Exchanging ATPase; Vasodilator Agents | 1994 |
Regulation of ATP-sensitive K+ channels by ATP and nucleotide diphosphate in rabbit portal vein.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Animals; Benzopyrans; Cromakalim; Egtazic Acid; Guanidines; In Vitro Techniques; Ion Channel Gating; Magnesium; Male; Membrane Potentials; Muscle, Smooth, Vascular; Niacinamide; Nicorandil; Pinacidil; Portal Vein; Potassium Channels; Probability; Pyrroles; Rabbits; Ribonucleotides; Time Factors; Vasodilator Agents | 1994 |
Effects of three K+ channel openers on airways and pulmonary circulation in the isolated guinea-pig lung.
Topics: Animals; Benzopyrans; Bronchoconstriction; Cromakalim; Dose-Response Relationship, Drug; Guanidines; Guinea Pigs; In Vitro Techniques; Lung; Male; Muscle Contraction; Muscle, Smooth, Vascular; Picolines; Pinacidil; Potassium; Potassium Channels; Pulmonary Circulation; Pyrans; Pyrroles | 1993 |
ATP-sensitive potassium channels and skeletal muscle function in vitro.
Topics: Animals; Benzopyrans; Cromakalim; Electric Stimulation; Energy Metabolism; Gallamine Triethiodide; Glyburide; Guanidines; In Vitro Techniques; Ischemia; Male; Muscle Contraction; Muscles; Pinacidil; Potassium Channels; Pyridines; Pyrroles; Rats; Rats, Sprague-Dawley | 1993 |
The effects of potassium channel openers on isolated pregnant human myometrium before and after the onset of labor: potential for tocolysis.
Topics: Benzopyrans; Cromakalim; Female; Guanidines; Humans; In Vitro Techniques; Labor Onset; Myometrium; Oxytocin; Phenylephrine; Pinacidil; Potassium Channels; Potassium Chloride; Pregnancy; Pyrroles; Sulfonylurea Compounds; Tocolytic Agents; Uterine Contraction | 1993 |
Arteriolar tone is determined by activity of ATP-sensitive potassium channels.
Topics: Adenosine Triphosphate; Animals; Arterioles; Benzopyrans; Bucladesine; Colforsin; Cricetinae; Cromakalim; Epoprostenol; Glyburide; Guanidines; Isoproterenol; Male; Mesocricetus; Methacholine Chloride; Muscle Tonus; Muscle, Smooth, Vascular; Muscles; Nitroprusside; Pinacidil; Potassium Channels; Pyrroles; Quaternary Ammonium Compounds; Vasoconstriction; Vasodilation; Vasodilator Agents | 1993 |
Potassium channel openers stimulate DNA synthesis in mouse epidermal keratinocyte and whole hair follicle cultures.
Topics: Animals; Benzopyrans; Cells, Cultured; Cromakalim; Diazoxide; DNA; Guanidines; Hair; Keratinocytes; Kinetics; Mice; Minoxidil; Pinacidil; Potassium Channels; Pyrroles; Vibrissae | 1993 |
Modulation of vasodilatation to levcromakalim by hypoxia and EDRF in the rabbit isolated ear: a comparison with pinacidil, sodium nitroprusside and verapamil.
Topics: Acetylcholine; Animals; Arginine; Benzopyrans; Cromakalim; Ear, External; Guanidines; Hypoxia; In Vitro Techniques; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitroprusside; Oxidative Phosphorylation; Pinacidil; Piperazines; Pyrroles; Rabbits; Receptors, N-Methyl-D-Aspartate; Regional Blood Flow; Vasodilator Agents; Verapamil | 1993 |
Pharmacological properties of ATP-sensitive K+ channels in mammalian skeletal muscle cells.
Topics: Adenosine Triphosphate; Animals; Benzopyrans; Cromakalim; Electrophysiology; Glyburide; Guanidines; In Vitro Techniques; Mice; Muscles; Niacinamide; Nicorandil; Organic Chemicals; Pinacidil; Potassium Channels; Pyrroles; Vasodilator Agents | 1993 |
Comparative electrophysiological and mechanical actions of ATP-sensitive potassium channel openers in canine Purkinje fibers.
Topics: Action Potentials; Adenosine Triphosphate; Animals; Benzopyrans; Cromakalim; Dogs; Electrophysiology; Glyburide; Guanidines; In Vitro Techniques; Myocardial Contraction; Niacinamide; Nicorandil; Pinacidil; Potassium Channels; Purkinje Fibers; Pyrroles; Tetraethylammonium Compounds; Vasodilator Agents | 1993 |
K+ channel openers prevent global ischemia-induced expression of c-fos, c-jun, heat shock protein, and amyloid beta-protein precursor genes and neuronal death in rat hippocampus.
Topics: Alternative Splicing; Amyloid beta-Protein Precursor; Animals; Base Sequence; Benzopyrans; Brain Ischemia; Cell Death; Cromakalim; Gene Expression Regulation; Guanidines; Heat-Shock Proteins; Hippocampus; In Situ Hybridization; Male; Molecular Sequence Data; Neurons; Niacinamide; Nicorandil; Oligonucleotide Probes; Pinacidil; Potassium Channels; Proto-Oncogene Proteins c-fos; Proto-Oncogene Proteins c-jun; Pyrroles; Rats; Rats, Wistar; RNA, Messenger | 1993 |
Relaxant effects of the potassium channel activators BRL 38227 and pinacidil on guinea-pig and human airway smooth muscle, and blockade of their effects by glibenclamide and BRL 31660.
Topics: Animals; Anti-Arrhythmia Agents; Benzopyrans; Bronchi; Cromakalim; Female; Glyburide; Guanidines; Guinea Pigs; Histamine; Humans; In Vitro Techniques; Male; Muscle Relaxation; Muscle, Smooth; Pinacidil; Potassium; Potassium Channels; Potassium Radioisotopes; Pyrroles; Pyrrolidines; Respiratory System; Trachea; Vasodilator Agents | 1993 |
Modulation of rabbit aortic Ca(2+)-activated K+ channels by pinacidil, cromakalim, and glibenclamide.
Topics: Animals; Aorta; Benzopyrans; Calcium; Cations; Cromakalim; Dose-Response Relationship, Drug; Glyburide; Guanidines; Lipid Bilayers; Membrane Potentials; Microsomes; Muscle, Smooth, Vascular; Pinacidil; Potassium Channels; Pyrroles; Rabbits; Vasodilator Agents | 1993 |
Effects of potassium channel openers in isolated human cerebral arteries.
Topics: Benzopyrans; Calcium Channel Blockers; Carbachol; Cerebral Arteries; Cromakalim; Culture Techniques; Dose-Response Relationship, Drug; Endothelium, Vascular; Guanidines; Humans; Iloprost; Nifedipine; Nimodipine; Pinacidil; Potassium Channels; Pyrroles; Vasodilator Agents | 1995 |
Two types of ATP-sensitive potassium channels in rat portal vein smooth muscle cells.
Topics: Adenosine Triphosphate; Animals; Benzopyrans; Cells, Cultured; Cromakalim; Glyburide; Guanidines; Male; Membrane Potentials; Muscle, Smooth, Vascular; Pinacidil; Portal Vein; Potassium Channels; Pyrroles; Rats; Rats, Wistar; Sensitivity and Specificity; Uridine Diphosphate | 1996 |
Effects of cromakalim, pinacidil and glibenclamide on cholinergic transmission in rat isolated atria.
Topics: Acetylcholine; Analysis of Variance; Animals; Benzopyrans; Cholinergic Fibers; Cromakalim; Female; Glyburide; Guanidines; Heart; Hypoglycemic Agents; Male; Pinacidil; Potassium Channels; Pyrroles; Rats; Rats, Sprague-Dawley; Vasodilator Agents | 1995 |
K+ channel openers delay intestinal transit and have antidiarrheal activity.
Topics: Animals; Benzopyrans; Cromakalim; Diarrhea; Dose-Response Relationship, Drug; Gastrointestinal Motility; Guanidines; Male; Mice; Mice, Inbred Strains; Morphine; Pinacidil; Potassium Channels; Pyrroles; Vasodilator Agents | 1995 |
Action potential duration and force-frequency relationship in isolated rabbit, guinea pig and rat cardiac muscle.
Topics: 4-Aminopyridine; Action Potentials; Animals; Benzopyrans; Cromakalim; Cytosol; Guanidines; Guinea Pigs; Heart; In Vitro Techniques; Myocardial Contraction; Pinacidil; Potassium Channel Blockers; Potassium Channels; Pyrroles; Rabbits; Rats; Sodium; Strophanthidin; Tetraethylammonium; Tetraethylammonium Compounds | 1996 |
The effects of pharmacological modulation of KATP on the guinea-pig isolated diaphragm.
Topics: Adenosine Triphosphate; Animals; Benzopyrans; Cromakalim; Diaphragm; Electrophysiology; Glyburide; Guanidines; Guinea Pigs; Indoles; Male; Membrane Potentials; Muscle Contraction; Muscle Tonus; Phentolamine; Pinacidil; Potassium Channels; Pyrroles | 1996 |
Identification and properties of an ATP-sensitive K+ current in rabbit sino-atrial node pacemaker cells.
Topics: Action Potentials; Adenosine Triphosphate; Animals; Benzopyrans; Cromakalim; Glyburide; Guanidines; Hydrogen-Ion Concentration; Kinetics; Myocardium; Patch-Clamp Techniques; Pinacidil; Potassium; Potassium Channel Blockers; Potassium Channels; Pyrroles; Rabbits; Sinoatrial Node; Sodium Cyanide; Vasodilator Agents | 1996 |
Modulation of vasorelaxant responses to potassium channel openers by basal nitric oxide in the rat isolated superior mesenteric arterial bed.
Topics: Animals; Benzopyrans; Cromakalim; Cyclic GMP; Dose-Response Relationship, Drug; Guanidines; In Vitro Techniques; Male; Mesenteric Artery, Superior; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitroprusside; Papaverine; Pinacidil; Potassium Channels; Pyrroles; Rats; Rats, Wistar; Stereoisomerism; Theophylline; Vasodilation; Vasodilator Agents | 1996 |
Modulation of vascular KATP channels in hypothyroidism.
Topics: Animals; Benzopyrans; Cromakalim; Dose-Response Relationship, Drug; Guanidines; Hypothyroidism; Male; Pinacidil; Portal Vein; Potassium Channels; Pyrroles; Rats; Vasodilator Agents | 1996 |
Inhibition of contractile responses of human myometrium and intramyometrial arteries by potassium channel openers.
Topics: Adult; Arteries; Benzopyrans; Cromakalim; Dose-Response Relationship, Drug; Female; Guanidines; Humans; In Vitro Techniques; Isometric Contraction; Muscle, Smooth, Vascular; Myometrium; Pinacidil; Potassium Channels; Pyrroles; Uterine Contraction; Vasodilator Agents | 1996 |
Enhancement of the ATP-sensitive K+ current by extracellular ATP in rat ventricular myocytes. Involvement of adenylyl cyclase-induced subsarcolemmal ATP depletion.
Topics: Adenine; Adenosine Triphosphate; Adenylyl Cyclase Inhibitors; Animals; Benzopyrans; Carbonyl Cyanide m-Chlorophenyl Hydrazone; Colforsin; Cromakalim; Deoxyadenine Nucleotides; Dose-Response Relationship, Drug; Enzyme Inhibitors; Extracellular Space; GTP-Binding Proteins; Guanidines; Guanosine Triphosphate; Heart Ventricles; Male; Patch-Clamp Techniques; Peptide Fragments; Pinacidil; Potassium Channels; Pyrroles; Rats; Rats, Wistar; Uncoupling Agents | 1997 |
KATP channel modulators increase survival rate during coronary occlusion-reperfusion in anaesthetized rats.
Topics: Action Potentials; Adenosine Triphosphate; Analysis of Variance; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Benzopyrans; Blood Pressure; Calcium Channel Blockers; Coronary Disease; Cromakalim; Disease Models, Animal; Dose-Response Relationship, Drug; Electrocardiography; Glyburide; Guanidines; Heart Rate; Male; Myocardial Reperfusion Injury; Pinacidil; Potassium Channels; Pyrroles; Rats; Rats, Sprague-Dawley; Survival Rate; Vasodilator Agents; Ventricular Fibrillation | 1997 |
Hypoxia-induced catecholamine release and intracellular Ca2+ increase via suppression of K+ channels in cultured rat adrenal chromaffin cells.
Topics: Animals; Benzopyrans; Buffers; Calcium; Carotid Body; Catecholamines; Cell Hypoxia; CHO Cells; Chromaffin Cells; Cricetinae; Cromakalim; Diazoxide; Glioma; Glyburide; Guanidines; Hybrid Cells; Hypoglycemic Agents; Male; Membrane Potentials; Minoxidil; Neuroblastoma; Parasympatholytics; Patch-Clamp Techniques; Pinacidil; Potassium; Potassium Channel Blockers; Potassium Channels; Pyrroles; Rats; Rats, Wistar; Vasodilator Agents | 1997 |