pinacidil has been researched along with propranolol in 13 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (23.08) | 18.7374 |
| 1990's | 4 (30.77) | 18.2507 |
| 2000's | 1 (7.69) | 29.6817 |
| 2010's | 5 (38.46) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ | 1 |
| Ekins, S; Williams, AJ; Xu, JJ | 1 |
| Barber, J; Dawson, S; Kenna, JG; Paul, N; Stahl, S | 1 |
| Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ | 1 |
| Liang, CS; Stone, CK; Sullebarger, JT; Wellington, KL; Willick, A | 1 |
| Goldberg, MR; Rockhold, FW; Thompson, WL | 1 |
| Byyny, RL; LoVerde, ME; Mitchell, WD; Nies, AS | 1 |
| Kawashima, S; Liang, CS | 1 |
| Kalsner, S | 1 |
| Chiba, S; Furukawa, Y; Hoyano, Y; Imamura, H; Kasama, M; Yonezawa, T | 1 |
| Chiba, S; Furukawa, Y; Lakhe, M; Nagashima, Y; Yonezawa, T | 1 |
| Dart, C; Hayabuchi, Y; Sampson, LJ; Standen, NB | 1 |
3 trial(s) available for pinacidil and propranolol
| Article | Year |
|---|---|
Acute hemodynamic effects of pinacidil in hypertensive patients with and without propranolol pretreatment.
Topics: Adult; Antihypertensive Agents; Double-Blind Method; Female; Forearm; Guanidines; Heart Rate; Hemodynamics; Humans; Hypertension; Male; Middle Aged; Pinacidil; Premedication; Propranolol; Regional Blood Flow | 1991 |
Beneficial effects of pinacidil on blood lipids: comparisons with prazosin and placebo in patients with hypertension. Pinacidil-Prazosin and Pinacidil-Placebo Research Groups, Lilly Research Laboratories.
Topics: Antihypertensive Agents; Cholesterol; Cholesterol, HDL; Cholesterol, LDL; Clinical Trials as Topic; Coronary Disease; Double-Blind Method; Guanidines; Humans; Hydrochlorothiazide; Pinacidil; Prazosin; Propranolol; Random Allocation; Risk Factors; Triglycerides | 1989 |
A double-blind, randomized, controlled trial comparing pinacidil to hydralazine in essential hypertension.
Topics: Adult; Aged; Blood Pressure; Body Weight; Clinical Trials as Topic; Delayed-Action Preparations; Double-Blind Method; Epinephrine; Female; Guanidines; Heart Rate; Humans; Hydralazine; Hydrochlorothiazide; Male; Middle Aged; Norepinephrine; Pinacidil; Propranolol; Random Allocation; Renin | 1987 |
10 other study(ies) available for pinacidil and propranolol
| Article | Year |
|---|---|
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Developing structure-activity relationships for the prediction of hepatotoxicity.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes | 2010 |
A predictive ligand-based Bayesian model for human drug-induced liver injury.
Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands | 2010 |
In vitro inhibition of the bile salt export pump correlates with risk of cholestatic drug-induced liver injury in humans.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Cholestasis; Drug-Related Side Effects and Adverse Reactions; Humans; Insecta; Rats; Risk Factors | 2012 |
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship | 2012 |
Systemic and coronary hemodynamic effects of pinacidil, a new antihypertensive agent, in awake dogs: comparison with hydralazine.
Topics: Aminophylline; Animals; Antihypertensive Agents; Blood Pressure; Cardiac Output; Coronary Circulation; Dogs; Guanidines; Heart Rate; Hemodynamics; Hydrazines; Indomethacin; Pinacidil; Propranolol; Vascular Resistance | 1985 |
Propranolol antagonizes coronary artery relaxation by a potassium channel opener.
Topics: Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Animals; Biological Transport; Cattle; Colforsin; Coronary Vessels; Cyclic AMP; Drug Interactions; Glyburide; Guanidines; Guinea Pigs; In Vitro Techniques; Muscle Relaxation; Muscle, Smooth; Muscle, Smooth, Vascular; Nitroprusside; Pinacidil; Potassium Channels; Propranolol; Rubidium Radioisotopes; Trachea; Vasodilator Agents | 1994 |
Inhibition by bertosamil of cardiac responses to pinacidil or Bay k 8644 in isolated dog atria and ventricles.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Acetylcholine; Animals; Bridged Bicyclo Compounds, Heterocyclic; Dogs; Dose-Response Relationship, Drug; Guanidines; Heart Atria; Heart Ventricles; Pinacidil; Propranolol; Vasodilator Agents | 1996 |
Chronotropic and inotropic effects of terikalant on isolated, blood-perfused atrial and ventricular preparations of dogs.
Topics: Acetylcholine; Adenosine; Adrenergic alpha-Agonists; Animals; Anti-Arrhythmia Agents; Atrial Function; Atropine; Chromans; Depression, Chemical; Dogs; Dose-Response Relationship, Drug; Drug Interactions; Female; Guanidines; Heart Rate; Male; Muscle Contraction; Norepinephrine; Pinacidil; Piperidines; Potassium Channels; Propranolol; Vasodilator Agents; Ventricular Function | 1997 |
Caveolae localize protein kinase A signaling to arterial ATP-sensitive potassium channels.
Topics: Adenosine Triphosphate; Adenylyl Cyclases; Animals; Aorta; ATP-Binding Cassette Transporters; Calcitonin Gene-Related Peptide; Caveolae; Caveolin 1; Caveolins; Cell Compartmentation; Cell Fractionation; Cholesterol; Cyclic AMP-Dependent Protein Kinases; Glyburide; Guanosine Diphosphate; Ion Transport; Isoenzymes; KATP Channels; Male; Membrane Lipids; Mesenteric Arteries; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Patch-Clamp Techniques; Peptide Fragments; Pinacidil; Potassium; Potassium Channels, Inwardly Rectifying; Propranolol; Rats; Rats, Wistar; Sphingolipids; Theophylline; Thionucleotides | 2004 |