pinacidil has been researched along with n-cyano-n'-(1,1-dimethylpropyl)-n''-(3-pyridinyl)guanidine in 25 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (8.00) | 18.7374 |
| 1990's | 10 (40.00) | 18.2507 |
| 2000's | 13 (52.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Arrigoni-Martelli, E; Nielsen, CK; Petersen, HJ | 1 |
| Manley, PW; Quast, U | 1 |
| Komatsu, K; Matsushita, Y; Moriguchi, I | 1 |
| Andres, H; Bray, K; Manley, PW; Quast, U | 1 |
| Atwal, KS; Bryson, CC; Cohen, RB; Dickinson, KE; Grover, GJ; Lodge, NJ; Normandin, DE; Sleph, PG; Traeger, SC | 1 |
| Agerholm, PC; Arkhammar, PO; Hansen, JB; Mogensen, JP; Tagmose, TM; Wahl, P; Worsaae, A | 1 |
| Bhattacharjee, S; Kraft, P; Li, X; Lundeen, SG; Qiu, Y; Sui, Z; Woods, M; Zhang, X | 1 |
| Balsamo, A; Bianucci, AM; Calderone, V; Coi, A; Digiacomo, M; Rapposelli, S; Testai, L | 1 |
| Abrahamsson, C; Carlsson, L; Drews, L; Duker, G | 1 |
| Kau, S; Levin, R; Li, J; Stetz, S; Trivedi, S | 1 |
| Sargent, C; Smith, MA; Weselcouch, EO; Wilde, MW | 1 |
| Barber, RD; Henderson, RM | 1 |
| Hambrock, A; Kickenweiz, E; Krippeit-Drews, P; Metzger, F; Quast, U; Russ, U | 1 |
| Aguilar-Bryan, L; Bryan, J; Dörschner, H; Gross, I; Schwanstecher, C; Schwanstecher, M; Sieverding, C | 1 |
| Gross, I; Schwanstecher, C; Schwanstecher, M; Toman, A; Uhde, I | 1 |
| Ashcroft, FM; Ashfield, R; Gribble, FM; Reimann, F | 1 |
| Ashcroft, FM; Gribble, FM; Reimann, F | 1 |
| Liu, Y; Marbán, E; O'Rourke, B; Ren, G; Seharaseyon, J | 1 |
| Brioni, JD; Buckner, SA; Coghlan, MJ; Feng, J; Gopalakrishnan, M; Shieh, CC; Sullivan, JP | 1 |
| Grover, GJ; Jilkina, O; Kupriyanov, VV; Kuzio, B | 1 |
| Fu, AL; He, HM; Long, CL; Wang, H; Zhang, LZ | 1 |
| Davies, NW; Hudman, D; Norman, RI; Rainbow, RD; Standen, NB | 1 |
| Bozdogan, O; Gonca, E; Nebigil, M; Tiryaki, ES | 1 |
| El-Bariaki, N; Jansen-Olesen, I; Mortensen, CH; Ploug, KB | 1 |
| Baun, M; Boni, LJ; Hay-Schmidt, A; Jansen-Olesen, I; Olesen, J; Ploug, KB | 1 |
25 other study(ies) available for pinacidil and n-cyano-n'-(1,1-dimethylpropyl)-n''-(3-pyridinyl)guanidine
| Article | Year |
|---|---|
Synthesis and hypotensive activity of N-alkyl-N"-cyano-N'-pyridylguanidines.
Topics: Animals; Antihypertensive Agents; Dogs; Female; Guanidines; Hypertension; Lethal Dose 50; Mice; Rats; Structure-Activity Relationship | 1978 |
Structure-activity studies of potassium channel opening in pinacidil-type cyanoguanidines, nitroethenediamines, thioureas, and ureas.
Topics: Animals; Diamines; Guanidines; Ion Channel Gating; Male; Molecular Conformation; Molecular Structure; Muscle Contraction; Pinacidil; Portal Vein; Potassium Channels; Rats; Rats, Inbred Strains; Rubidium Radioisotopes; Structure-Activity Relationship; Thiourea; Urea; Vasodilator Agents | 1992 |
Adaptive least-squares method applied to structure--activity correlation of hypotensive N-alkyl-N''-cyano-N'-pyridylguanidines.
Topics: Antihypertensive Agents; Guanidines; Mathematics; Models, Theoretical; Statistics as Topic; Structure-Activity Relationship | 1980 |
Synthesis of and radioligand binding studies with a tritiated pinacidil analogue: receptor interactions of structurally different classes of potassium channel openers and blockers.
Topics: Animals; Binding Sites; Drug Interactions; Guanidines; Muscle, Smooth, Vascular; Pinacidil; Potassium Channels; Pyridines; Rats; Structure-Activity Relationship; Vasodilator Agents | 1993 |
Binding of ATP-sensitive potassium channel (KATP) openers to cardiac membranes: correlation of binding affinities with cardioprotective and smooth muscle relaxing potencies.
Topics: Animals; ATP-Binding Cassette Transporters; Cardiotonic Agents; Dogs; KATP Channels; Muscle Relaxation; Muscle, Smooth; Myocardium; Potassium Channels; Potassium Channels, Inwardly Rectifying; Protein Binding; Structure-Activity Relationship | 1998 |
Phenylcyanoguanidines as inhibitors of glucose-induced insulin secretion from beta cells.
Topics: Cell Line; Glucose; Guanidines; Humans; In Vitro Techniques; Insulin; Insulin Antagonists; Insulin Secretion; Islets of Langerhans | 2001 |
Discovery and structure-activity relationships of a novel series of benzopyran-based K(ATP) openers for urge urinary incontinence.
Topics: Animals; Benzopyrans; Disease Models, Animal; Potassium Channels, Inwardly Rectifying; Rats; Structure-Activity Relationship; Urinary Bladder; Urinary Incontinence, Urge | 2009 |
Predictive models, based on classification algorithms, for compounds potentially active as mitochondrial ATP-sensitive potassium channel openers.
Topics: Algorithms; Benzopyrans; Cardiotonic Agents; KATP Channels; Models, Chemical; Molecular Structure; Quantitative Structure-Activity Relationship; Spiro Compounds | 2009 |
Antiarrhythmic effects of potassium channel openers in rhythm abnormalities related to delayed repolarization.
Topics: Animals; Anti-Arrhythmia Agents; Electrocardiography; Glyburide; Guanidines; Heart Conduction System; Long QT Syndrome; Male; Pinacidil; Potassium Channels; Pyridines; Quaternary Ammonium Compounds; Rabbits; Stereoisomerism; Torsades de Pointes | 1992 |
Effect of cromakalim and pinacidil on 86Rb efflux from guinea pig urinary bladder smooth muscle.
Topics: Adenosine Triphosphate; Animals; Benzopyrans; Cromakalim; Dose-Response Relationship, Drug; Guanidines; Guinea Pigs; Male; Membrane Potentials; Muscle, Smooth; Pinacidil; Potassium Channels; Pyridines; Pyrroles; Rubidium Radioisotopes; Stereoisomerism; Urinary Bladder; Vasodilator Agents | 1994 |
ATP-sensitive potassium channels and skeletal muscle function in vitro.
Topics: Animals; Benzopyrans; Cromakalim; Electric Stimulation; Energy Metabolism; Gallamine Triethiodide; Glyburide; Guanidines; In Vitro Techniques; Ischemia; Male; Muscle Contraction; Muscles; Pinacidil; Potassium Channels; Pyridines; Pyrroles; Rats; Rats, Sprague-Dawley | 1993 |
Inhibition by P1075 and pinacidil of a calcium-independent chloride conductance in conditionally-immortal renal glomerular mesangial cells.
Topics: Animals; Calcium; Cell Line, Transformed; Chloride Channels; Glomerular Mesangium; Guanidines; Mice; Pinacidil; Pyridines; Quaternary Ammonium Compounds | 1996 |
Binding and effects of KATP channel openers in the vascular smooth muscle cell line, A10.
Topics: Animals; Aorta, Thoracic; Binding, Competitive; Cell Line; Cromakalim; Glyburide; Guanidines; Membrane Potentials; Minoxidil; Muscle, Smooth, Vascular; Patch-Clamp Techniques; Pinacidil; Potassium Channel Blockers; Potassium Channels; Pyridines; Radioligand Assay; Rats; Vasodilator Agents | 1997 |
Potassium channel openers require ATP to bind to and act through sulfonylurea receptors.
Topics: Adenosine Triphosphate; Animals; ATP-Binding Cassette Transporters; Binding Sites; Binding, Competitive; Cricetinae; Diazoxide; Glyburide; Guanidines; Humans; Mutation; Peptide Fragments; Pinacidil; Potassium Channels; Potassium Channels, Inwardly Rectifying; Protein Isoforms; Pyridines; Receptors, Drug; Recombinant Proteins; Sulfonylurea Receptors | 1998 |
Stoichiometry of potassium channel opener action.
Topics: Animals; ATP-Binding Cassette Transporters; Binding Sites; COS Cells; Dose-Response Relationship, Drug; Electrophysiology; Guanidines; Pinacidil; Potassium Channels; Potassium Channels, Inwardly Rectifying; Pyridines; Receptors, Drug; Recombinant Fusion Proteins; Sulfonylurea Receptors; Vasodilator Agents | 1999 |
Nucleotide modulation of pinacidil stimulation of the cloned K(ATP) channel Kir6.2/SUR2A.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Animals; Antihypertensive Agents; Binding Sites; Guanidines; Mice; Mutation; Oocytes; Pinacidil; Potassium Channels; Potassium Channels, Inwardly Rectifying; Protein Conformation; Pyridines; Tritium; Vasodilator Agents; Xenopus laevis | 2000 |
Differential response of K(ATP) channels containing SUR2A or SUR2B subunits to nucleotides and pinacidil.
Topics: Adenosine Triphosphate; Animals; Electrophysiology; Guanidines; Mice; Mutation; Pinacidil; Potassium Channels; Potassium Channels, Inwardly Rectifying; Pyridines; Rats; Vasodilator Agents | 2000 |
Pharmacological comparison of native mitochondrial K(ATP) channels with molecularly defined surface K(ATP) channels.
Topics: Animals; ATP-Binding Cassette Transporters; Cells, Cultured; Diazoxide; Glyburide; Guanidines; Heart Ventricles; Humans; KATP Channels; Membrane Proteins; Mitochondria, Heart; Myocardium; Patch-Clamp Techniques; Pinacidil; Potassium Channels; Potassium Channels, Inwardly Rectifying; Pyridines; Rabbits; Receptors, Drug; Recombinant Proteins; Sulfonylurea Receptors; Vasodilator Agents | 2001 |
Functional implication of spare ATP-sensitive K(+) channels in bladder smooth muscle cells.
Topics: Acetylcholine; Amides; Animals; Benzophenones; Drug Interactions; Electrophysiology; Guanidines; Guinea Pigs; In Vitro Techniques; Membrane Potentials; Membrane Proteins; Muscle Relaxation; Muscle, Smooth; Pinacidil; Potassium Channels; Pyridines; Swine; Urinary Bladder; Vasodilator Agents | 2001 |
Effects of K(ATP) channel openers, P-1075, pinacidil, and diazoxide, on energetics and contractile function in isolated rat hearts.
Topics: 2,4-Dinitrophenol; Adenosine Triphosphate; Animals; Diazoxide; Guanidines; Heart; In Vitro Techniques; Magnetic Resonance Spectroscopy; Male; Myocardial Contraction; Myocardium; Oxidative Phosphorylation; Oxygen Consumption; Perfusion; Phosphocreatine; Pinacidil; Potassium Channel Blockers; Potassium Channels; Pyridines; Rats; Rats, Sprague-Dawley; Vasodilator Agents | 2002 |
Alteration of binding sites for [3H]P1075 and [3H]glibenclamide in renovascular hypertensive rat aorta.
Topics: Animals; Antihypertensive Agents; Aorta; Binding Sites; Glyburide; Guanidines; Hypertension, Renovascular; In Vitro Techniques; Kinetics; Male; Pinacidil; Potassium Channels; Pyridines; Rats; Rats, Wistar; Vasodilator Agents | 2005 |
Reduced effectiveness of HMR 1098 in blocking cardiac sarcolemmal K(ATP) channels during metabolic stress.
Topics: Action Potentials; Adenosine Diphosphate; Animals; ATP-Binding Cassette Transporters; Benzamides; Guanidines; Iodoacetates; Male; Myocytes, Cardiac; Patch-Clamp Techniques; Pinacidil; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Inwardly Rectifying; Pyridines; Rats; Rats, Wistar; Receptors, Drug; Sarcolemma; Sodium Cyanide; Sulfonylurea Compounds; Sulfonylurea Receptors | 2005 |
Effect of thimerosal on arrhythmia induced by coronary ligation: the involvement of ATP-dependent potassium channels.
Topics: Adenosine Triphosphate; Animals; Arrhythmias, Cardiac; Blood Pressure; Coronary Vessels; Electrocardiography; Guanidines; Heart Rate; Ligation; Male; Myocardial Reperfusion; Myocardial Reperfusion Injury; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase Type II; Pinacidil; Potassium Channel Blockers; Potassium Channels; Pyridines; Rats; Rats, Sprague-Dawley; Thimerosal | 2005 |
Characterization of K(ATP)-channels in rat basilar and middle cerebral arteries: studies of vasomotor responses and mRNA expression.
Topics: Animals; ATP-Binding Cassette Transporters; Basilar Artery; Binding Sites; Chlorocebus aethiops; COS Cells; Endothelium, Vascular; Glyburide; Guanidines; Ion Channel Gating; KATP Channels; Male; Middle Cerebral Artery; Multidrug Resistance-Associated Proteins; Organic Chemicals; Pinacidil; Potassium Channels; Potassium Channels, Inwardly Rectifying; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, Drug; RNA, Messenger; Sulfonylurea Receptors; Transfection; Vasodilation; Vasodilator Agents | 2005 |
K(ATP) channel expression and pharmacological in vivo and in vitro studies of the K(ATP) channel blocker PNU-37883A in rat middle meningeal arteries.
Topics: Adamantane; Animals; ATP-Binding Cassette Transporters; Blotting, Western; Cromakalim; Data Interpretation, Statistical; Diuretics; Guanidines; In Vitro Techniques; KATP Channels; Male; Meningeal Arteries; Microscopy, Video; Morpholines; Multidrug Resistance-Associated Proteins; Pinacidil; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Inwardly Rectifying; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, Drug; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sulfonylurea Receptors; Vasodilator Agents | 2008 |