pinacidil has been researched along with hydralazine in 24 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 21 (87.50) | 18.7374 |
| 1990's | 1 (4.17) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (8.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Arrigoni-Martelli, E; Nielsen, CK; Petersen, HJ | 1 |
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ | 1 |
| Yuhara, M | 1 |
| Imamura, N; Kurokawa, K; Nakajima, S; Ueda, M | 1 |
| Byyny, RL; LoVerde, ME; Marshall, G; Mitchell, WD; Rudd, P; Titus, C; Zachary, V | 1 |
| Carlsen, JE; Kardel, T; Lund, JO; McNair, A; Trap-Jensen, J | 1 |
| Eggertsen, R; Hansson, L | 1 |
| Imai, S; Matsui, K; Ogawa, Y | 1 |
| Carlsen, JE; Jensen, HA; Lund, JO; Rehling, M; Trap-Jensen, J | 1 |
| Brunelle, R; Callaghan, JT; Goldberg, MR | 1 |
| Abe, Y; Fujioka, S; Fukui, K; Iwao, H; Kimura, S; Tamaki, T | 1 |
| Byyny, RL; LoVerde, ME; Mitchell, WD; Nies, AS | 1 |
| Abraham, PA; Halstenson, CE; Keane, WF; Matzke, GR | 1 |
| Matsumura, Y; Morimoto, S; Sasaki, Y | 1 |
| Nakajima, S; Ueda, M | 1 |
| Kageyama, M; Matsumura, Y; Morimoto, S; Sasaki, Y; Takakuwa, T | 1 |
| Collins, JB; Fisher, LD; Schirger, A; Sheps, SG; Shub, C; Spiekerman, RE; Zachariah, PK | 1 |
| Matsuda, S; Ueda, M | 1 |
| Thoolen, MJ; Timmermans, PB; Van Meel, JC; van Zwieten, PA; Wilffert, B | 1 |
| Carlsen, JE; Hilden, T; Kardel, T; Tangø, M; Trap-Jensen, J | 1 |
| Arrigoni-Martelli, E; Nielsen, CK | 1 |
| Arrigoni-Martelli, E; Nielsen, CK; Olsen, UB; Petersen, HJ | 1 |
| de los Angeles Sánchez-Salvatori, M; Ríos, C; Vidrio, H | 1 |
1 review(s) available for pinacidil and hydralazine
| Article | Year |
|---|---|
Vasodilators in hypertension--a review with special emphasis on the combined use of vasodilators and beta-adrenoceptor blockers.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Angiotensin-Converting Enzyme Inhibitors; Calcium Channel Blockers; Carbazoles; Carvedilol; Diazoxide; Dihydralazine; Drug Therapy, Combination; Glomerular Filtration Rate; Guanidines; Humans; Hydralazine; Hypertension; Minoxidil; Pinacidil; Plasma Volume; Propanolamines; Pyridazines; Renin-Angiotensin System; Serotonin Antagonists; Vascular Resistance; Vasodilator Agents | 1985 |
7 trial(s) available for pinacidil and hydralazine
| Article | Year |
|---|---|
The natural history of medication compliance in a drug trial: limitations of pill counts.
Topics: Antihypertensive Agents; Clinical Trials as Topic; Female; Guanidines; Humans; Hydralazine; Hypertension; Male; Middle Aged; Patient Compliance; Pinacidil | 1989 |
Acute hemodynamic effects of pinacidil and hydralazine in essential hypertension.
Topics: Adrenergic beta-Antagonists; Adult; Blood Pressure; Cardiac Output; Double-Blind Method; Drug Evaluation; Drug Interactions; Female; Guanidines; Heart Rate; Hemodynamics; Humans; Hydralazine; Hypertension; Injections, Intravenous; Male; Metoprolol; Middle Aged; Pinacidil; Random Allocation; Stroke Volume; Vascular Resistance | 1985 |
Long term haemodynamic effects of pinacidil and hydralazine in arterial hypertension.
Topics: Antihypertensive Agents; Blood Pressure; Clinical Trials as Topic; Glomerular Filtration Rate; Guanidines; Hemodynamics; Humans; Hydralazine; Hypertension; Middle Aged; Pinacidil; Random Allocation | 1988 |
Double-blind comparator trials with pinacidil, a potassium channel opener.
Topics: Antihypertensive Agents; Blood Pressure; Clinical Trials as Topic; Double-Blind Method; Guanidines; Heart Rate; Humans; Hydralazine; Hypertension; Methyldopa; Middle Aged; Pinacidil; Potassium Channels; Prazosin; Random Allocation | 1988 |
A double-blind, randomized, controlled trial comparing pinacidil to hydralazine in essential hypertension.
Topics: Adult; Aged; Blood Pressure; Body Weight; Clinical Trials as Topic; Delayed-Action Preparations; Double-Blind Method; Epinephrine; Female; Guanidines; Heart Rate; Humans; Hydralazine; Hydrochlorothiazide; Male; Middle Aged; Norepinephrine; Pinacidil; Propranolol; Random Allocation; Renin | 1987 |
Comparison of antihypertensive, renal hemodynamic, and humoral effects of pinacidil and hydralazine monotherapy.
Topics: Adolescent; Adult; Aged; Antihypertensive Agents; Blood Pressure; Clinical Trials as Topic; Double-Blind Method; Female; Glomerular Filtration Rate; Guanidines; Heart Rate; Humans; Hydralazine; Hypertension; Male; Middle Aged; Pinacidil; Renal Circulation; Renin-Angiotensin System; Vascular Resistance | 1987 |
Antihypertensive efficacy of pinacidil--automatic ambulatory blood pressure monitoring.
Topics: Adult; Antihypertensive Agents; Circadian Rhythm; Double-Blind Method; Female; Guanidines; Heart Rate; Humans; Hydralazine; Hypertension; Male; Middle Aged; Monitoring, Physiologic; Pinacidil; Prospective Studies; Random Allocation | 1986 |
16 other study(ies) available for pinacidil and hydralazine
| Article | Year |
|---|---|
Synthesis and hypotensive activity of N-alkyl-N"-cyano-N'-pyridylguanidines.
Topics: Animals; Antihypertensive Agents; Dogs; Female; Guanidines; Hypertension; Lethal Dose 50; Mice; Rats; Structure-Activity Relationship | 1978 |
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship | 2012 |
[Clinical application of vascular smooth muscle relaxants in the treatment of hypertension].
Topics: Guanidines; Humans; Hydralazine; Hypertension; Nitroglycerin; Parasympatholytics; Pinacidil; Pyridazines | 1989 |
A study on the hypotensive mechanism of pinacidil: relationship between its vasodilating effect and intracellular Ca2+ levels.
Topics: Animals; Antihypertensive Agents; Calcium; Cyclic AMP; Cyclic GMP; Dose-Response Relationship, Drug; Guanidines; Guinea Pigs; Hydralazine; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth, Vascular; Nifedipine; Pinacidil; Rabbits; Sulfonamides; Trifluoperazine; Vasodilation | 1989 |
Relaxant effects of pinacidil, nicorandil, hydralazine and nifedipine as studied in the porcine coronary artery and guinea-pig taenia coli.
Topics: Animals; Caffeine; Colon; Coronary Vessels; Female; Guanidines; Guinea Pigs; Hydralazine; In Vitro Techniques; Male; Muscle Relaxation; Muscle, Smooth; Muscle, Smooth, Vascular; Niacinamide; Nicorandil; Nifedipine; Pinacidil; Potassium; Swine; Vasodilator Agents | 1986 |
Effects of an antihypertensive vasodilator, pinacidil, on regional blood flow in conscious spontaneously hypertensive rats.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Guanidines; Heart Rate; Hemodynamics; Hydralazine; Microspheres; Pinacidil; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Regional Blood Flow; Vasodilator Agents | 1988 |
Effects of pinacidil on renal hemodynamics and function in anesthetized dogs.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Denervation; Dogs; Dose-Response Relationship, Drug; Glomerular Filtration Rate; Guanidines; Hemodynamics; Hydralazine; Infusions, Intra-Arterial; Injections, Intravenous; Kidney; Pinacidil; Renal Circulation; Renin; Urine; Vascular Resistance | 1986 |
[Pharmacological studies on pinacidil, a new antihypertensive agent. (3). Studies on the vasodilating effects in isolated monkey arteries and the peripheral hypotensive mechanism in SHR].
Topics: Animals; Antihypertensive Agents; Arteries; Guanidines; Heart Rate; Hydralazine; In Vitro Techniques; Macaca fascicularis; Nifedipine; Pinacidil; Rats; Rats, Inbred SHR; Stimulation, Chemical; Vasodilation | 1987 |
Diuretic effect induced by intrarenal infusion of pinacidil in anesthetized dogs.
Topics: Anesthesia; Animals; Blood Pressure; Bradykinin; Diuretics; Dogs; Glomerular Filtration Rate; Guanidines; Hydralazine; Indomethacin; Kidney; Phosphates; Pinacidil; Renal Circulation; Sodium; Vasodilator Agents | 1987 |
[Pharmacological studies on pinacidil, a new anti-hypertensive agent. 1. Antihypertensive effects in SHR and DOC/saline hypertensive rats].
Topics: Administration, Oral; Animals; Antihypertensive Agents; Desoxycorticosterone; Female; Guanidines; Hydralazine; Hypertension; Male; Nifedipine; Pinacidil; Rats; Rats, Inbred SHR; Sex Factors; Sodium Chloride | 1985 |
Hemodynamic characterization of pinacidil in rats. Comparison with hydralazine.
Topics: Animals; Blood Pressure; Cardiac Output; Dose-Response Relationship, Drug; Guanidines; Heart Rate; Hemodynamics; Hydralazine; Male; Muscle, Smooth, Vascular; Pinacidil; Pressoreceptors; Radioligand Assay; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Vasodilator Agents | 1983 |
Immediate central and peripheral haemodynamic effects of a new vasodilating agent Pinacidil (P1134) in hypertensive man.
Topics: Adult; Blood Pressure; Cardiac Output; Female; Guanidines; Heart Rate; Hemodynamics; Humans; Hydralazine; Hypertension; Male; Middle Aged; Pinacidil; Pyridines; Stroke Volume; Vascular Resistance; Vasodilator Agents | 1981 |
Effect of a new vasodilator, pinacidil (P 1134), on potassium, noradrenaline and serotonin induced contractions in rabbit vascular tissues.
Topics: Animals; Aorta, Thoracic; Calcium; Calcium Channel Blockers; Female; Guanidines; Hydralazine; In Vitro Techniques; Male; Muscle, Smooth, Vascular; Norepinephrine; Pinacidil; Potassium; Pyridines; Rabbits; Serotonin Antagonists; Vasoconstriction; Vasodilator Agents | 1981 |
N''-cyano-N-4-pyridyl-N'-1,2,2-trimethylpropylguanidine, monohydrate (P 1134): a new, potent vasodilator.
Topics: Animals; Blood Pressure; Cardiac Output; Dogs; Dose-Response Relationship, Drug; Guanidines; Heart Rate; Hydralazine; Hypertension; Hypertension, Renal; Pinacidil; Pyridines; Rats; Vasodilator Agents | 1980 |
Interaction between isoniazid and diverse vasodilators: role of decreased cerebral GABA.
Topics: Animals; Blood Pressure; Captopril; Dipyridamole; Drug Synergism; gamma-Aminobutyric Acid; Guanidines; Heart Rate; Hydralazine; Hypothalamus; Isoniazid; Male; Minoxidil; Pinacidil; Pons; Prazosin; Rats; Rats, Wistar; Vasodilator Agents | 1998 |