pinacidil has been researched along with glyburide in 312 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 8 (2.56) | 18.7374 |
| 1990's | 147 (47.12) | 18.2507 |
| 2000's | 120 (38.46) | 29.6817 |
| 2010's | 37 (11.86) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Andres, H; Bray, K; Manley, PW; Quast, U | 1 |
| Aguilar-Bryan, L; Bryan, J; Clement, JP; Gonoi, T; Inagaki, N; Seino, S; Wang, CZ | 1 |
| Higashiguchi, O; Horio, Y; Isomoto, S; Kondo, C; Kurachi, Y; Matsumoto, S; Matsuzawa, Y; Yamada, M | 1 |
| Atwal, KS; Bryson, CC; Cohen, RB; Dickinson, KE; Grover, GJ; Lodge, NJ; Normandin, DE; Sleph, PG; Traeger, SC | 1 |
| Bellows, DS; Clarke, ID; Diamandis, P; Dirks, PB; Graham, J; Jamieson, LG; Ling, EK; Sacher, AG; Tyers, M; Ward, RJ; Wildenhain, J | 1 |
| Austin, CP; Fidock, DA; Hayton, K; Huang, R; Inglese, J; Jiang, H; Johnson, RL; Su, XZ; Wellems, TE; Wichterman, J; Yuan, J | 1 |
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Barber, J; Dawson, S; Kenna, JG; Paul, N; Stahl, S | 1 |
| de Tullio, P; Gailly, P; Goffin, E; Kiss, R; Lamoral-Theys, D; Lefranc, F; Mondin, L; Pirotte, B; Rogister, B; Tajeddine, N | 1 |
| Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ | 1 |
| Brodsky, JL; Chiang, A; Chung, WJ; Denny, RA; Goeckeler-Fried, JL; Havasi, V; Hong, JS; Keeton, AB; Mazur, M; Piazza, GA; Plyler, ZE; Rasmussen, L; Rowe, SM; Sorscher, EJ; Weissman, AM; White, EL | 1 |
| Braida, C; Holzmann, S; Kukovetz, WR; Pöch, G | 1 |
| Gopalakrishnan, M; Triggle, DJ | 1 |
| Cook, D; Stockbridge, N; Vollrath, B; Weir, B; Zhang, H | 1 |
| Edwards, G; Henshaw, M; Miller, M; Weston, AH | 1 |
| Chiba, S; Furukawa, Y; Karasawa, Y; Murakami, M; Ren, LM; Takayama, S | 1 |
| Behrends, S; Brandt, C; Panten, U; Schaupp, U; Schwanstecher, M | 1 |
| Karim, OM; Mostwin, JL; Seki, N | 1 |
| Kau, ST; Li, JH; Zografos, P | 1 |
| Kamijo, T; Kido, H; Miwa, A; Nakamura, F; Sugimoto, T; Tomaru, T; Uchida, Y | 1 |
| Kato, H; Shimada, F; Takata, Y | 1 |
| Li, YQ; Triggle, CR; Wyse, DG | 1 |
| Abdelrahman, A; Chang, SD; Pang, CC; Wang, YX | 1 |
| Chang, JK; Fineman, JR; Heymann, MA; Moore, P; Soifer, SJ | 1 |
| Lau, WM | 1 |
| Imamura, Y; Kasuya, H; Narishige, T; Takahashi, T; Takeshita, A; Tomoike, H | 1 |
| Abrahamsson, C; Carlsson, L; Drews, L; Duker, G | 1 |
| Horacek, J; Lefebvre, RA | 1 |
| Angel, I; Bidet, S | 1 |
| Cohen, AS; Matteson, DR; Parsey, RV; Sala, S | 1 |
| Chinn, K; Martin, CL | 1 |
| Charette, L; Garcia, ML; Jones, TR; Kaczorowski, GJ | 1 |
| Nakayama, K; Takeshita, N; Tanaka, Y; Watanabe, N; Yamazawa, T; Yanaihara, N | 1 |
| Hood, JS; Kadowitz, PJ; McMahon, TJ | 1 |
| Kajioka, S; Kitamura, K; Kuriyama, H | 1 |
| Higuera, TR; Kadowitz, PJ; Kvamme, P; Minkes, RK; Nossaman, BD | 1 |
| Satoh, K; Taira, N; Yamada, H | 1 |
| Ksoll, E; Mackert, JR; Parsons, AA; Schilling, L; Wahl, M | 1 |
| Bemis, KG; Ertel, PJ; Robertson, DW; Steinberg, MI; Wiest, SA; Zimmerman, KM | 1 |
| Gackenheimer, SL; Gehlert, DR; Mais, DE; Robertson, DW | 1 |
| Hellstrand, P; Lydrup, ML | 1 |
| Chen, G; Miwa, K; Suzuki, H; Yamamoto, Y | 1 |
| Kajioka, S; Kitamura, K; Kuriyama, H; Sakai, T; Xiong, ZL | 1 |
| Cole, WC; McPherson, CD; Sontag, D | 1 |
| Halpern, W; McCarron, JG; Nelson, MT; Quayle, JM | 1 |
| Kanno, M; Nakaya, H; Takeda, Y; Tohse, N | 1 |
| Honoré, E; Lazdunski, M | 2 |
| Bang, L; Brønsgaard, AM; Nielsen-Kudsk, JE | 1 |
| Asano, M; Masuzawa, K; Matsuda, T | 1 |
| Angus, JA; McPherson, GA | 1 |
| Antoine, MH; Berkenboom, G; Fang, ZY; Fontaine, J; Herchuelz, A; Hermann, M; Lebrun, P | 1 |
| Downing, SJ; Hollingsworth, M; Minshall, E; Piper, I; Sadraei, H | 1 |
| Taira, N; Teshigawara, T; Yanagisawa, T | 1 |
| Satoh, E; Taira, N; Yanagisawa, T | 1 |
| Asano, M; Imaizumi, Y; Masuzawa, K; Matsuda, T; Watanabe, M | 1 |
| Wilson, C | 1 |
| Brayden, JE; Davies, NW; Huang, Y; Nelson, MT; Quayle, JM; Standen, NB | 1 |
| Sanguinetti, MC; Siegl, PK; Wolleben, CD | 1 |
| Conder, ML; Grover, GJ; Henry, DE; McCullough, JR; Sleph, PG | 1 |
| Cavero, I; Courteix, J; Escande, D; Laville, M; Le Guern, S; Thuringer, D | 1 |
| Arena, JP; Kass, RS | 1 |
| Hollingsworth, M; Piper, I | 1 |
| Eltze, M | 1 |
| Friedman, M; Johnson, RG; Sellke, FW; Wang, SY; Zeind, AJ | 1 |
| Khan, SA; Mathews, WR; Meisheri, KD | 1 |
| Satoh, H | 2 |
| Abrahams, Z; Sutter, MC | 1 |
| Burns, DM; Howard, GA; Kawase, T; Roos, BA | 1 |
| Chi, L; Fagbemi, SO; Lucchesi, BR | 1 |
| Gojković, L; Kazić, T | 1 |
| Bolton, TB; Zhang, H | 1 |
| Akimitsu, T; Gute, DC; Jerome, SN; Korthuis, RJ | 1 |
| Barnett, CW; Bishop, BE; Doggrell, SA | 1 |
| Bache, RJ; Duncker, DJ; Herrlinger, SK; Pavek, TJ; van Zon, NS | 1 |
| Parsons, AA; Schilling, L; Wahl, M | 1 |
| Chujo, M; Mohamed, MU; Mori, H; Nakazawa, H; Shinozaki, Y; Tanaka, E; Yamakawa, A | 1 |
| Akatsuka, Y; Egashira, K; Imamura, Y; Kasuya, H; Narishige, T; Takahashi, T; Takeshita, A | 1 |
| Kalsner, S | 2 |
| D'Alonzo, AJ; Darbenzio, RB; Grover, GJ; Hess, TA; Sewter, JC; Sleph, PG | 1 |
| Akatsuka, Y; Egashira, K; Katsuda, Y; Narishige, T; Shimokawa, H; Takeshita, A; Ueno, H | 1 |
| Cohen, MV; Daly, JJ; Downey, JM; Thornton, JD; Tsuchida, A; Walsh, RS | 1 |
| Buchanan, LV; Cimini, MG; Gibson, JK; Khan, SA; Meisheri, KD; Norman, NR; Shebuski, RJ; Toombs, CF | 1 |
| Arase, S; Hamaoka, H; Kato, S; Nakaya, Y | 1 |
| Fan, Z; Frame, M; Groppi, V; Holevinsky, KO; Makielski, JC; Nelson, DJ | 1 |
| Ito, M; Pride, HP; Zipes, DP | 1 |
| Adelman, JP; Ashford, ML; Blair, TA; Bond, CT | 1 |
| Makujina, SR; Mustafa, SJ; Olanrewaju, HA | 1 |
| Clapham, JC; Hamilton, TC; Trail, BK | 1 |
| Belyaeva, EA; Mikołajek, B; Nałecz, MJ; Szewczyk, A; Wojtczak, L | 1 |
| Hurt, CM; Pelleg, A; Wang, L; Xu, J | 1 |
| Black, SC; Chi, L; Fagbemi, SO; Friedrichs, GS; Lucchesi, BR | 1 |
| Sargent, C; Smith, MA; Weselcouch, EO; Wilde, MW | 1 |
| Jackson, WF | 1 |
| Cole, WC; McPherson, CD; Pierce, GN | 1 |
| Adnot, S; Carville, C; Chabrier, PE; Eddahibi, S; Levame, M; Mannan, M; Polak, J; Raffestin, B; Springall, D | 1 |
| Dehring, DJ; Johnson, RL; Nelson, SH; Suresh, MS | 1 |
| Ebisu, H; Eda, M; Fukaya, C; Gohda, M; Hihara, M; Matzno, S; Nakamura, N; Okada, T; Sakashita, H; Takemoto, T | 1 |
| Nakaya, H | 1 |
| Allard, B; Lazdunski, M | 1 |
| Downey, JM; Sterling, DL; Thornton, CS; Thornton, JD | 1 |
| Hosoya, Y; Ikeno, E; Kubota, I; Shibata, T; Tomoike, H; Yamaki, M | 1 |
| Links, TP; Oosterhuis, HJ; Reitsma, WD; Smit, AJ | 1 |
| Hoffman, FJ; Janis, RA; Lenfers, JB; Niemers, E; Pleiss, U; Scriabine, A | 1 |
| Arch, JR; Bowring, NE; Buckle, DR; Foster, KA; Shaw, DJ; Taylor, JF; Taylor, SG | 1 |
| Van Wagoner, DR | 1 |
| Gelband, GH; McCullough, JR | 1 |
| Boban, M; Bosnjak, ZJ; Gross, GJ; Kampine, JP; Pieper, GM; Stowe, DF | 1 |
| Armstrong, SC; Downey, JM; Ganote, CE; Liu, GS | 1 |
| Bache, RJ; Duncker, DJ; Ishibashi, Y; van Zon, NS | 1 |
| Quayle, JM; Standen, NB; Wellman, GC | 1 |
| Baczkó, I; Leprán, I; Papp, JG; Varró, A | 1 |
| Egashira, K; Numaguchi, K; Sakata, M; Shimokawa, H; Takeshita, A | 1 |
| Bolton, TB; Zhang, HL | 1 |
| Nakanishi, T; Nanbu, A; Nishimura, M; Sakamoto, M; Takahashi, H; Yoshimura, M | 1 |
| Fabiani, ME; Story, DF | 1 |
| Kelly, E; Kumar, P; Poucher, SM; Prior, H; Russell, K; Wickenden, AD | 1 |
| French, RJ; Giles, WR; Han, X; Light, PE | 1 |
| Brusasco, V; Crimi, E; Lazzarotti, M; Rehder, K; Rocchi, D; Song, P | 1 |
| Goto, K; Ikeda, S; Morita, T; Nishimura, N; Sukamoto, T; Yoshiizumi, K; Yoshino, K | 1 |
| Belardinelli, L; Song, Y; Srinivas, M | 1 |
| Arletti, R; Benelli, A; Bertolini, A; Cavazzuti, E; Mameli, M; Poggioli, R | 1 |
| Allen, CT; Damiano, RJ; Hsia, PW; Lawton, JS | 1 |
| Horio, Y; Isomoto, S; Kondo, C; Kurachi, Y; Matsumoto, S; Shindo, T; Yamada, M | 1 |
| Baczkó, I; Leprán, I; Papp, JG | 1 |
| Matsumura, K; Mochizuki-Oda, N; Oosawa, Y; Takeuchi, Y; Watanabe, Y | 1 |
| Chae, SW; Chang, SH; Cho, KW; Kim, SH; Kim, SZ | 1 |
| Damon, DH; Lange, DL | 1 |
| Bychkov, R; Gollasch, M; Haller, H; Luft, FC; Ried, C | 1 |
| Deka, DK; Mishra, SK; Raviprakash, V | 2 |
| Halvorsen, SW; Lu, C | 1 |
| Daut, J; Langheinrich, U | 1 |
| Hambrock, A; Kickenweiz, E; Krippeit-Drews, P; Metzger, F; Quast, U; Russ, U | 1 |
| Bojić, M; Djukanović, B; Gojkoviíc Bukarica, L; Kazić, T; Panić, G; Perić, M; Sajić, Z | 1 |
| Beresewicz, A; Maczewski, M | 1 |
| Kato, Y; Matsuda, T; Noguchi, K; Okazaki, K; Saito, W; Shigenobu, K; Tanaka, H | 1 |
| D'Alonzo, AJ; Darbenzio, RB; Dorso, CR; Grover, GJ; Zhu, JL | 1 |
| Bartolini, A; Galeotti, N; Ghelardini, C | 1 |
| Ashford, ML; Khan, RN; Morrison, JJ; Smith, SK | 1 |
| Burns, DM; Kawase, T | 1 |
| Aguilar-Bryan, L; Bryan, J; Dörschner, H; Gross, I; Schwanstecher, C; Schwanstecher, M; Sieverding, C | 1 |
| Nurse, CA; Thompson, RJ | 1 |
| Guo, ZG; Shi, DH | 1 |
| Hashimoto, S; Kawata, T; Koike, T; Mimuro, T; Nihei, H; Onuki, T; Tsuchiya, K | 1 |
| Liang, BT | 1 |
| Aguilar-Bryan, L; Babenko, AP; Bryan, J; Gonzalez, G | 1 |
| Frangos, JA; Gudi, SR; Ishizaka, H; Kuo, L | 1 |
| Kwan, YW; Lau, WM; To, KW; Tsang, SH | 1 |
| Du, ZY; Hicks, M; Jansz, P; Macdonald, PS; Rainer, S; Spratt, P | 1 |
| Huang, Y; Lau, CW | 1 |
| Kecskeméti, V; Losonczy, G; Mucha, I; Nánási, PP; Pacher, P; Ungvári, Z | 1 |
| Carpenter, E; Peers, C; Roberts, ML; Taylor, SC | 1 |
| Dong, C; Duffield, R; Ho, AK; Tang, T | 1 |
| Matsuda, N; Morgan, KG; Sellke, FW | 2 |
| Mizuno, R; Ohhashi, T; Ono, N | 1 |
| Gojković-Bukarica, L; Kazić, T | 1 |
| Gonoi, T; Inagaki, N; Ishida, H; Seino, S; Seino, Y; Sunaga, Y; Yamada, Y | 1 |
| Foldes, FF; Matkó, I; Nagashima, H; Oe, K; Sántha, E; Sperlágh, B; Vizi, ES | 1 |
| Homeister, JW; Kilgore, KS; Lucchesi, BR; McGeer, PL; Tanhehco, EJ; Washington, RA; Yasojima, K | 1 |
| Dallaporta, M; Orsini, JC; Perrin, J | 1 |
| Konduri, GG; Mital, S | 1 |
| Matar, W; Nosek, TM; Renaud, J; Wong, D | 1 |
| Horie, M; Ishida, H; Ishida-Takahashi, A; Sasayama, S; Seino, Y; Tsuji, K; Watanuki, M; Yuzuki, Y | 1 |
| Galiñanes, M; Ghosh, S; Standen, NB | 1 |
| Firth, TA; Mawe, GM; Nelson, MT | 1 |
| Kamei, J; Morita, K | 1 |
| Elliott, RA; Hudman, D; Norman, RI | 1 |
| Gupta, S; Irani, AN; Malhi, H; McDonald, TV; Rajvanshi, P; Spray, DC; Suadicani, SO | 1 |
| Bast, JP; Carmines, PK; Fallet, RW; Ikenaga, H | 1 |
| Chen, SJ; Lin, CI; Wu, CC; Yang, SN; Yen, MH | 1 |
| Iahupol's'kyĭ, LM; Moĭbenko, OO; Strutyns'kyĭ, RB | 1 |
| Beauwens, R; Boom, A; Frerotte, M; Golstein, PE; Sande, JV | 1 |
| Kaley, G; Koller, A; Massett, MP | 1 |
| Dacey, RG; Dietrich, HH; Horiuchi, T; Tsugane, S | 1 |
| Liu, Y; Marbán, E; O'Rourke, B; Ren, G; Seharaseyon, J | 1 |
| Lerman, A; Mathew, V | 1 |
| Kang, YY; Kim, JA; Lee, YS | 1 |
| Brading, AF; Ito, Y; Teramoto, N | 1 |
| Bernhart, E; Koidl, B; Lang, P; Mächler, H; Pelzmann, B; Rigler, B; Schaffer, P | 1 |
| Li, RA; Marbán, E; Miki, T; Nakaya, H; Ogura, T; Ohmoto-Sekine, Y; Sakamoto, N; Seino, S; Suzuki, M; Tamagawa, M; Uemura, H | 1 |
| Haikala, H; Kaheinen, P; Levijoki, J; Pollesello, P | 1 |
| Christ, GJ; Wang, HZ | 1 |
| Christ, GJ; Karicheti, V; Kuo, E; Melman, A; Santizo, C; Shenk, G; Zhao, W | 1 |
| Aranda, H; Dooley, DJ; Eckhardt, K; Feuerstein, TJ; Freiman, TM; Heinemeyer, J; Kukolja, J; Rominger, A; Zentner, J | 1 |
| Jasmin, BJ; Lunde, JA; Matar, W; Renaud, JM | 1 |
| Li, Q; Puro, DG | 1 |
| Jun, JY; Koh, SD; Kong, ID; Perrino, BA; Sanders, KM; Wang, XY; Ward, SM | 1 |
| Bielfeld-Ackermann, A; Konstas, AA; Korbmacher, C | 1 |
| Dick, JM; Lefebvre, RA; Libert, C; Van Molle, W | 1 |
| Brown, RA; Petrovski, P; Ren, J; Savage, AO | 1 |
| Kang, TM; Kim, KW; Kim, YC; Park, SJ; Sim, JH; So, I; Yang, DK | 1 |
| McCurrie, JR; Wood, D; Yeung, CK | 1 |
| Castañeda-Hernández, G; Granados-Soto, V; Ortiz, MI; Rosas, R; Torres-López, JE; Vidal-Cantú, GC | 1 |
| Crystal, GJ; Hu, G; Salem, MR; Vinten-Johansen, J; Zhao, ZQ | 1 |
| Han, J; Joo, H; Kim, E; Kim, N; Park, J; Seog, DH | 1 |
| Englert, H; Kilbinger, H; Krause, A; Mang, CF; Wirth, K | 1 |
| Fukuse, T; Hirata, T; Omasa, M; Wada, H | 1 |
| Christ, GJ; Giraldi, A; Melman, A; Spektor, M; Venkateswarlu, K; Wang, HZ; Zhao, W | 1 |
| Heywood, GJ; Thomas, PS | 1 |
| Gomes, P; Soares-Da-Silva, P | 1 |
| Cheng, JT; Huang, WC; Lai, TY; Liu, IM; Tsai, CC | 1 |
| Kamei, J; Morita, K; Onodera, K | 1 |
| Cao, K; Hu, D; Tang, G; Wang, R | 1 |
| Jilkina, O; Kupriyanov, VV; Sun, J; Xiang, B | 1 |
| Berkan, O; Safak, C; Saraç, B; Sarioğlu, Y; Simşek, R; Yildirim, S | 1 |
| Tai, KK; Truong, DD | 1 |
| Kamei, J; Onodera, K; Zushida, K | 1 |
| Houston, RJ; Legtenberg, RJ; Oeseburg, B; Rongen, GA; Smits, P | 1 |
| Braun, GS; Horster, MF; Huber, SM; Segerer, S; Veh, RW | 1 |
| Cartier, EA; Shen, S; Shyng, SL | 1 |
| Bosnjak, ZJ; Gassmayr, S; Kwok, WM; Stadnicka, A; Suzuki, A | 1 |
| El-Mahmoudy, A; Matsuyama, H; Shimizu, Y; Takewaki, T; Thapaliya, S | 1 |
| Kito, Y; Suzuki, H | 1 |
| Hogan, Q; Kwok, WM; McCallum, B; Sapunar, D; Sarantopoulos, C | 1 |
| Birkmayer, GD; Hallström, S; Koidl, B; Lang, P; Nadlinger, K; Pelzmann, B; Reibnegger, G; Schaffer, P; Vrecko, K | 1 |
| Ding, HL; Dong, JW; Zhou, ZN; Zhu, HF; Zhu, WZ | 1 |
| Chae, MR; Choi, JW; Insuk, SO; Lee, SW; Sim, JH; Yang, DK | 1 |
| Dirnagl, U; Dreier, JP; Lindauer, U; Schuh-Hofer, S; Vogt, J | 1 |
| Di Girolamo, N; Heywood, GJ; Thomas, PS; Wei, XM | 1 |
| Houston, RJ; Legtenberg, RJ; Oeseburg, B; Smits, P | 1 |
| Drolet, B; Roden, DM; Simard, C | 1 |
| Berthiaume, Y; Brochiero, E; Dagenais, A; Leroy, C | 1 |
| Kawano, T; Kitahata, H; Kuroda, Y; Nakaya, Y; Oshita, S; Takahashi, A; Tomiyama, Y; Tsutsumi, Y | 1 |
| Clemmensen, P; Gadsbøll, N; Haunsø, S; Hesse, B; Kelbaek, H; Lindhardt, TB; Madsen, JK; Saunamäki, K | 1 |
| Crystal, GJ; Hu, G; Salem, MR | 1 |
| Miki, T; Miura, T | 1 |
| Dart, C; Hayabuchi, Y; Sampson, LJ; Standen, NB | 1 |
| Aalkjaer, C; Forman, A; Glavind-Kristensen, M; Hansen, VB; Matchkov, V; Nilsson, H | 1 |
| Kito, Y; Sanders, KM; Ward, SM | 1 |
| Fu, AL; He, HM; Long, CL; Wang, H; Zhang, LZ | 1 |
| Gozalov, A; Jansen-Olesen, I; Klaerke, D; Mortensen, C; Olesen, J; Petersen, KA | 1 |
| Hu, G; Zhang, Y | 1 |
| Qi, X; Wang, H; Xie, WP; Zhang, XL | 1 |
| Kogi, K; Konno, T; Nagai, A; Nakahata, N; Uchibori, T | 1 |
| Cao, C; Lee-Kwon, W; Pallone, TL; Silldorff, EP | 1 |
| Andersen, CU; Laursen, BE; López-Valverde, V; Mulvany, MJ; Simonsen, U | 1 |
| Abedini, S; Gadsbøll, N; Haunsø, S; Lindhardt, TB; Olesen, RM | 1 |
| Mandi, G; Mishra, SK; Raviprakash, V; Sarkar, SN | 1 |
| El-Bariaki, N; Jansen-Olesen, I; Mortensen, CH; Ploug, KB | 1 |
| Ding, JH; Hu, G; Liu, X; Sun, XL; Wu, JY; Yang, Y; Yao, HH; Zhou, F | 1 |
| Cheong, H; Choi, S; Jun, JY; Kim, KW; Kim, MY; Park, CG; Paudyal, DP; So, I; Yeum, CH; Yoon, PJ | 1 |
| Austin, C; Heagerty, AM; Izzard, AS; Lynch, FM | 1 |
| Acevedo, JJ; Darszon, A; de la Vega-Beltrán, JL; Felix, R; Mendoza-Lujambio, I; Treviño, CL | 1 |
| Flores-Murrieta, FJ; Granados-Soto, V; Mixcoatl-Zecuatl, T | 1 |
| Bagcivan, I; Kaya, T; Turan, M; Yildirim, MK | 1 |
| Hirano, Y; Hiraoka, M; Kocić, I; Petrusewicz, J | 1 |
| Aigrain, Y; Barbet, JP; de Buys Roessingh, AS; de Lagausie, P; Dinh-Xuan, AT; Mercier, JC | 1 |
| Honda, T; Kamata, K; Kanie, N; Kikuchi, T; Kobayashi, T; Makino, A; Matsumoto, T; Nishimura, M; Oda, S | 1 |
| Fujita, H; Imamaki, M; Ishida, A; Kimura, F; Miyazaki, M; Nakaya, H; Ogura, T; Sato, T; Tamagawa, M; Uemura, H | 1 |
| Aishima, M; Ito, Y; Naito, S; Nakano, T; Seki, N; Sueishi, K; Teramoto, N; Tomoda, T; Yonemitsu, Y; Yunoki, T | 1 |
| Gendviliene, V; Gurskaite, H; Martisiene, I; Stankevicius, A; Zablockaite, D | 1 |
| Sung, RJ; Wu, AZ; Wu, SN | 1 |
| Bueno, R; Moeslinger, T; Schmid, D; Spieckermann, PG; Staudacher, DL | 1 |
| Kathirvel, K; Parija, SC; Sardar, KK; Vijayakumar, C | 1 |
| Al Abed, A; Brock, JA; Tan, JH | 1 |
| Cui, N; Jiang, C; Shi, W; Shi, Y; Yang, Y; Zhang, X | 1 |
| Broch-Lips, M; Nielsen, OB; Overgaard, K; Praetorius, HA | 1 |
| Bache, RJ; Chen, Y; Hou, M; Li, Y; Traverse, JH | 1 |
| Ishii, K; Kametaka, S; Mori, A; Nakahara, T; Ogawa, N; Saito, M; Sakamoto, K | 1 |
| Djokic, J; Gojkovic-Bukarica, L; Heinle, H; Milovanovic, S; Novakovic, R; Protic, D | 1 |
| Chang, NC; Lee, TM; Lin, MS | 2 |
| Eguchi, S; Kawano, T; Mawatari, K; Nakajo, N; Nakaya, Y; Oshita, S; Takahashi, A; Tanaka, K; Yasui, S | 1 |
| Ishii, K; Mori, A; Nakahara, T; Nakazawa, T; Saito, M; Sakamoto, K | 1 |
| Cairns, BE; Dong, XD; Mann, MK; Mok, E; Svensson, P | 1 |
| Franova, S; Nosalova, G; Sutovska, M | 1 |
| Camara, AK; Eells, JT; Heinen, A; Henry, MM; Riess, ML; Stowe, DF | 1 |
| Aras-López, R; Balfagon, G; Blanco-Rivero, J; Cobeño, L; Cogolludo, A; Ferrer, M; Gamallo, C; Pérez-Vizcaino, F | 1 |
| Bae, I; Cha, SD; Cho, C; Kwon, SH; Park, SH; Ramachandran, S; Seo, EW; Song, DK | 1 |
| Cao, YX; Fan, LH; Hu, Z; Huo, JH; Ma, AQ; Tian, HY; Wang, J | 1 |
| Benamer, N; Bescond, J; Bois, P; Cantereau, A; Delwail, A; Demolombe, S; Faivre, JF; Moha Ou Maati, H | 1 |
| Chilton, L; Figura, M; Giles, WR; Knight, D; Kubes, P; Liacini, A; Millar, TM; Patel, K; Phan, V; Tibbles, LA; Viskovic, MM | 1 |
| Chang, NC; Chen, CC; Kang, CS; Lee, TM; Lin, CC | 1 |
| Dicay, M; Martin, GR; McKnight, W; Vong, L; Wallace, JL | 1 |
| Franova, S; Sutovska, M; Sutovsky, J | 1 |
| Efimov, IR; Fedorov, VV; Flagg, TP; Glukhov, AV; Nichols, CG | 1 |
| Fang, LP; Lin, Q; Liu, XM; Tang, CS | 1 |
| Chen, ML; Guo, LS; Li, YB; Liu, XL; Yang, XC; Zhong, GZ | 1 |
| Andrade, F; Huerta, M; Montoya-Pérez, R; Ortiz, M; Saavedra-Molina, A; Sánchez-Pastor, E; Trujillo, X | 1 |
| Daida, H; Matsumoto, A; Miyata, Y; Nakaya, H; Nakazato, Y; Nishimura, N; Ogura, T; Reien, Y; Suzuki, K | 1 |
| Chae, H; Choi, S; Jeon, JH; Jun, JY; Kim, BJ; Kim, SJ; Kwon, YK; So, I | 1 |
| Breschi, MC; Calderone, V; Cecchetti, V; Martelli, A; Sabatini, S; Testai, L | 1 |
| Moibenko, OO; Shuba, YM; Strutynskyi, RB; Tinker, A; Voitychuk, OI; Yagupolskii, LM | 1 |
| Balfagón, G; Blanco-Rivero, J; Cogolludo, A; del Campo, L; Márquez-Rodas, I; Nava, MP; Pérez-Vizcaíno, F; Sastre, E | 1 |
| He, HM; Long, CL; Wang, H | 1 |
| Behr-Roussel, D; Bernabé, J; Chartier-Kastler, E; Comperat, E; Denys, P; Giuliano, F; Gorny, D; Oger, S | 1 |
| Adebiyi, A; Jaggar, JH; Leffler, CW; Leo, MD; Liang, GH; McNally, EM | 1 |
| Du, X; Wang, C; Zhang, H | 1 |
| Britton, F; Dixon, R; Hwang, S; Sanders, K; Ward, S | 1 |
| Chen, SA; Chen, YC; Chen, YJ; Cheng, CC; Huang, JH; Lai, MS; Lin, CI; Lin, YK | 1 |
| Ducza, E; Falkay, G; Gáspár, R; Lovász, N | 1 |
| Bardou, O; Berthiaume, Y; Brochiero, E; Dagenais, A; Migneault, F; Privé, A; Roy-Camille, K | 1 |
| Bai, Q; He, J; Qiu, J; Wang, S; Wang, Y; Xiu, Y; Yu, C | 1 |
| Jamal Mustafa, S; Ledent, C; Nayeem, MA; Ponnoth, DS; Tilley, SL | 1 |
| Li, L; Ling, MY; Liu, L; Ma, ZY; Qi, J; Wang, YY; Zhang, Y | 1 |
| Benamer, N; Coetzee, WA; Mahoney, VM; Morley, GE; Steinhardt, MJ; Vasquez, C | 1 |
| Behmoaras, J; Buján, J; Escoubet, B; Jacob, MP; Lacolley, P; Lannoy, M; Pezet, M; Sloboda, N; Slove, S | 1 |
| Beleslin-Cokic, B; Gojkovic-Bukarica, L; Heinle, H; Ilic, B; Novakovic, R; Radunovic, N; Scepanovic, R | 1 |
| Fan, L; Pan, HL; Ren, J; Tian, Y; Wang, X; Wang, Y; Wu, J; Xia, H; Xu, L; Yang, S; Yao, W; Zhang, C; Zhang, D | 1 |
| Fu, ZJ; Li, DL; Ling, MY; Ma, ZY; Yan, CZ; Zhang, Y | 1 |
| An, SS; Chan-Li, Y; DeSantiago, B; Fitzgerald, R; Foster, DB; Horton, MR; Kim, JY; Lee, DY; Panettieri, RA; Wang, R; Yang, G | 1 |
| Domokos, D; Falkay, G; Gaspar, R; Koncz, A; Lovasz, N | 1 |
| Inai, T; Node, K; Takahara, K; Teramoto, N; Yamamoto, T | 1 |
| Chen, Y; Fan, Z; Huang, L; Lin, W; Tan, W; Wen, T; Yin, C | 1 |
| Adachi, T; Fujisawa, S; Hongoh, M; Ohba, T; Ono, K; Shimbo, T | 1 |
| Chen, JD; Lei, Y; Li, S | 1 |
| Chen, M; Feng, J; Lan, J; Li, J; Liang, W; Song, M; Zhang, W; Zheng, D | 1 |
| Kim, SH; Lee, GJ; Li, W; Park, BM; Yu, L | 1 |
2 review(s) available for pinacidil and glyburide
| Article | Year |
|---|---|
[Potential role of ATP-sensitive K+ channels in ischemia- and reperfusion-induced arrhythmias].
Topics: Action Potentials; Adenosine Triphosphate; Animals; Arrhythmias, Cardiac; Benzopyrans; Cromakalim; Glyburide; Guanidines; Humans; Myocardial Ischemia; Myocardial Reperfusion Injury; Myocardium; Niacinamide; Nicorandil; Pinacidil; Potassium; Potassium Channels; Pyrroles; Tolbutamide | 1993 |
ATP-sensitive K+ channel openers: old drugs with new clinical benefits for the heart.
Topics: Adenosine Triphosphate; Animals; Coronary Circulation; Coronary Disease; Diazoxide; Glyburide; Humans; Ion Channel Gating; Myocardial Reperfusion Injury; Nicorandil; Pinacidil; Potassium Channel Blockers; Potassium Channels; Randomized Controlled Trials as Topic; Vasodilator Agents | 2003 |
3 trial(s) available for pinacidil and glyburide
| Article | Year |
|---|---|
Potassium channels in hypokalaemic periodic paralysis: a key to the pathogenesis?
Topics: Adult; Blood Glucose; Female; Glucose; Glyburide; Guanidines; Humans; Hypokalemia; Insulin; Male; Muscles; Paralyses, Familial Periodic; Pinacidil; Potassium Channels | 1993 |
Pharmacological modulation of the ATP sensitive potassium channels during repeated coronary occlusions: no effect on myocardial ischaemia or function.
Topics: Adenosine Triphosphate; Angina Pectoris; Anti-Arrhythmia Agents; Balloon Occlusion; Coronary Stenosis; Double-Blind Method; Female; Glyburide; Humans; Ischemic Preconditioning, Myocardial; Male; Middle Aged; Myocardial Ischemia; Pinacidil; Potassium Channel Blockers; Potassium Channels; Stroke Volume; Vasodilator Agents; Ventricular Dysfunction, Left | 2004 |
Effects of pharmacological modulation of the ATP-sensitive potassium channels on the development of warm-up angina pectoris.
Topics: Adenosine Triphosphate; Aged; Angina Pectoris; Anti-Arrhythmia Agents; Blood Pressure; Double-Blind Method; Electrocardiography; Exercise Test; Female; Glyburide; Heart Rate; Humans; Male; Middle Aged; Pinacidil; Potassium Channel Blockers; Treatment Outcome; Vasodilator Agents | 2006 |
307 other study(ies) available for pinacidil and glyburide
| Article | Year |
|---|---|
Synthesis of and radioligand binding studies with a tritiated pinacidil analogue: receptor interactions of structurally different classes of potassium channel openers and blockers.
Topics: Animals; Binding Sites; Drug Interactions; Guanidines; Muscle, Smooth, Vascular; Pinacidil; Potassium Channels; Pyridines; Rats; Structure-Activity Relationship; Vasodilator Agents | 1993 |
A family of sulfonylurea receptors determines the pharmacological properties of ATP-sensitive K+ channels.
Topics: Adenosine Triphosphate; Amino Acid Sequence; Animals; ATP-Binding Cassette Transporters; Cloning, Molecular; Gene Expression; Molecular Sequence Data; Potassium Channels; Potassium Channels, Inwardly Rectifying; Rats; Receptors, Drug; Recombinant Proteins; RNA, Messenger; Sequence Alignment; Sequence Homology, Amino Acid; Signal Transduction; Sulfonylurea Receptors; Tissue Distribution | 1996 |
A novel sulfonylurea receptor forms with BIR (Kir6.2) a smooth muscle type ATP-sensitive K+ channel.
Topics: Adenosine Triphosphate; Amino Acid Sequence; Animals; ATP-Binding Cassette Transporters; Base Sequence; Cell Line; Cloning, Molecular; DNA, Complementary; Humans; Mice; Molecular Sequence Data; Muscle, Smooth; Potassium Channels; Potassium Channels, Inwardly Rectifying; Rats; Receptors, Drug; Sulfonylurea Receptors | 1996 |
Binding of ATP-sensitive potassium channel (KATP) openers to cardiac membranes: correlation of binding affinities with cardioprotective and smooth muscle relaxing potencies.
Topics: Animals; ATP-Binding Cassette Transporters; Cardiotonic Agents; Dogs; KATP Channels; Muscle Relaxation; Muscle, Smooth; Myocardium; Potassium Channels; Potassium Channels, Inwardly Rectifying; Protein Binding; Structure-Activity Relationship | 1998 |
Chemical genetics reveals a complex functional ground state of neural stem cells.
Topics: Animals; Cell Survival; Cells, Cultured; Mice; Molecular Structure; Neoplasms; Neurons; Pharmaceutical Preparations; Sensitivity and Specificity; Stem Cells | 2007 |
Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum.
Topics: Animals; Antimalarials; ATP Binding Cassette Transporter, Subfamily B, Member 1; Chromosome Mapping; Crosses, Genetic; Dihydroergotamine; Drug Design; Drug Resistance; Humans; Inhibitory Concentration 50; Mutation; Plasmodium falciparum; Quantitative Trait Loci; Transfection | 2009 |
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
In vitro inhibition of the bile salt export pump correlates with risk of cholestatic drug-induced liver injury in humans.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Cholestasis; Drug-Related Side Effects and Adverse Reactions; Humans; Insecta; Rats; Risk Factors | 2012 |
N-Aryl-N'-(chroman-4-yl)ureas and thioureas display in vitro anticancer activity and selectivity on apoptosis-resistant glioblastoma cells: screening, synthesis of simplified derivatives, and structure-activity relationship analysis.
Topics: Antineoplastic Agents; Apoptosis; Astrocytes; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Drug Screening Assays, Antitumor; Gene Expression Regulation, Neoplastic; Glioblastoma; Humans; Inhibitory Concentration 50; KATP Channels; Structure-Activity Relationship; Thiourea | 2012 |
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship | 2012 |
Increasing the Endoplasmic Reticulum Pool of the F508del Allele of the Cystic Fibrosis Transmembrane Conductance Regulator Leads to Greater Folding Correction by Small Molecule Therapeutics.
Topics: Alleles; Benzoates; Cells, Cultured; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Endoplasmic Reticulum; Furans; Gene Deletion; HEK293 Cells; HeLa Cells; High-Throughput Screening Assays; Humans; Hydroxamic Acids; Microscopy, Fluorescence; Protein Folding; Protein Structure, Tertiary; Pyrazoles; RNA, Messenger; Small Molecule Libraries; Ubiquitination; Vorinostat | 2016 |
Pharmacological interaction experiments differentiate between glibenclamide-sensitive K+ channels and cyclic GMP as components of vasodilation by nicorandil.
Topics: Animals; Benzopyrans; Cattle; Coronary Vessels; Cromakalim; Cyclic GMP; Drug Interactions; Glyburide; Guanidines; In Vitro Techniques; Methylene Blue; Molsidomine; Muscle Relaxation; Niacinamide; Nicorandil; Nitroprusside; Pinacidil; Potassium Channels; Pyrroles; Sensitivity and Specificity; Vasodilator Agents | 1992 |
Regulation of ATP-sensitive K+ channels by chronic glyburide and pinacidil administration.
Topics: Adenosine Triphosphate; Animals; Apamin; Brain; Calcium; Calcium Channels; Glyburide; Guanidines; Heart; Hemodynamics; Iodine Radioisotopes; Isradipine; Kinetics; Male; Membranes; Myocardium; Pinacidil; Potassium Channels; Radioligand Assay; Rats; Rats, Sprague-Dawley; Sensitivity and Specificity; Time Factors; Tritium; Vasodilator Agents | 1992 |
Vasodilatation of canine cerebral arteries by nicorandil, pinacidil and lemakalim.
Topics: Animals; Basilar Artery; Benzopyrans; Cerebral Arteries; Cromakalim; Dogs; Female; Glyburide; Guanidines; Guanylate Cyclase; In Vitro Techniques; Male; Methylene Blue; Muscle Contraction; Muscle, Smooth, Vascular; Niacinamide; Nicorandil; Pinacidil; Potassium Channels; Pyrroles; Vasodilation; Vasodilator Agents | 1992 |
Comparison of the effects of several potassium-channel openers on rat bladder and rat portal vein in vitro.
Topics: Animals; Benzopyrans; Cromakalim; Glyburide; Guanidines; In Vitro Techniques; Male; Pinacidil; Portal Vein; Potassium; Potassium Channels; Pyrroles; Rats; Rats, Sprague-Dawley; Urinary Bladder | 1991 |
Inhibition by glibenclamide of negative chronotropic and inotropic responses to pinacidil, acetylcholine, and adenosine in the isolated dog heart.
Topics: Acetylcholine; Adenosine; Adenosine Triphosphate; Analysis of Variance; Animals; Depression, Chemical; Dogs; Glyburide; Guanidines; Heart Atria; Heart Rate; Heart Ventricles; In Vitro Techniques; Myocardial Contraction; Pinacidil; Potassium Channels; Vasodilator Agents | 1992 |
Effect of MgATP on pinacidil-induced displacement of glibenclamide from the sulphonylurea receptor in a pancreatic beta-cell line and rat cerebral cortex.
Topics: Adenosine Triphosphate; Animals; ATP-Binding Cassette Transporters; Binding, Competitive; Cells, Cultured; Cerebral Cortex; Glyburide; Guanidines; Islets of Langerhans; Kidney; Male; Microsomes; Pinacidil; Potassium Channels; Potassium Channels, Inwardly Rectifying; Rats; Rats, Wistar; Receptors, Drug; Sulfonylurea Receptors | 1992 |
Effect of pinacidil on the membrane electrical activity of guinea pig detrusor muscle.
Topics: Animals; Carbachol; Dose-Response Relationship, Drug; Glyburide; Guanidines; Guinea Pigs; Membrane Potentials; Muscle, Smooth; Nifedipine; Pinacidil; Urinary Bladder; Vasodilator Agents | 1992 |
Comparison of the in vitro effects of K+ channel modulators on detrusor and portal vein strips from guinea pigs.
Topics: Animals; Benzopyrans; Cromakalim; Dose-Response Relationship, Drug; Glyburide; Guanidines; Guinea Pigs; In Vitro Techniques; Male; Minoxidil; Muscle, Smooth; Muscle, Smooth, Vascular; Niacinamide; Nicorandil; Pinacidil; Portal Vein; Potassium Channels; Potassium Chloride; Pyrroles; Vasoconstriction; Vasodilator Agents | 1992 |
[The vasospasmolytic effects of nicorandil, cromakalim and pinacidil on 3,4-diaminopyridine-induced phasic contractions in canine coronary arteries as an experimental vasospasm model].
Topics: 4-Aminopyridine; Amifampridine; Animals; Benzopyrans; Coronary Vasospasm; Cromakalim; Disease Models, Animal; Dogs; Female; Glyburide; Guanidines; In Vitro Techniques; Ion Channel Gating; Male; Methylene Blue; Niacinamide; Nicorandil; Pinacidil; Potassium Channels; Pyrroles; Vasodilator Agents | 1992 |
Differential effects of diazoxide, cromakalim and pinacidil on adrenergic neurotransmission and 86Rb+ efflux in rat brain cortical slices.
Topics: Animals; Benzopyrans; Cerebral Cortex; Cocaine; Cromakalim; Diazoxide; Electric Stimulation; Glyburide; Guanidines; Hydrocortisone; In Vitro Techniques; Male; Norepinephrine; Pinacidil; Potassium Channels; Pyrroles; Rats; Rats, Wistar; Rubidium Radioisotopes | 1992 |
Comparative effects of the K+ channel openers, pinacidil and cromakalim on vascular tone: sensitivity to glyburide and calcium.
Topics: Animals; Benzopyrans; Calcium; Cromakalim; Female; Glyburide; Guanidines; Humans; In Vitro Techniques; Isometric Contraction; Muscle Tonus; Muscle, Smooth, Vascular; Pinacidil; Potassium Channels; Pregnancy; Pyrroles; Rats; Rats, Inbred Strains; Ryanodine; Vasodilator Agents | 1992 |
Mechanism of the vasodilator action of calcitonin gene-related peptide in conscious rats.
Topics: Adenosine Triphosphate; Analysis of Variance; Animals; Antihypertensive Agents; Arginine; Blood Pressure; Calcitonin Gene-Related Peptide; Glyburide; Guanidines; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitroprusside; Phenylephrine; Pinacidil; Potassium Channels; Rats; Rats, Inbred Strains; Vasodilator Agents | 1992 |
K+ channel pulmonary vasodilation in fetal lambs: role of endothelium-derived nitric oxide.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Acetylcholine; Animals; Arginine; Blood Pressure; Female; Fetus; Glyburide; Guanidines; Nitric Oxide; Nitroarginine; Pinacidil; Potassium Channels; Pregnancy; Pulmonary Circulation; Sheep; Vasodilation; Vasodilator Agents | 1992 |
Effects of potassium channel blockers on the negative inotropic responses induced by cromakalim and pinacidil in guinea pig atrium.
Topics: Adenosine Triphosphate; Animals; Antihypertensive Agents; Benzopyrans; Cromakalim; Depression, Chemical; Female; Glyburide; Guanidines; Guinea Pigs; Heart Atria; Myocardial Contraction; Pinacidil; Potassium Channels; Pyrroles; Stereoisomerism; Tacrine | 1992 |
Glibenclamide decreases basal coronary blood flow in anesthetized dogs.
Topics: Animals; Coronary Circulation; Dogs; Female; Glyburide; Guanidines; Male; Nitroprusside; Pinacidil; Vasodilation; Vasodilator Agents | 1992 |
Antiarrhythmic effects of potassium channel openers in rhythm abnormalities related to delayed repolarization.
Topics: Animals; Anti-Arrhythmia Agents; Electrocardiography; Glyburide; Guanidines; Heart Conduction System; Long QT Syndrome; Male; Pinacidil; Potassium Channels; Pyridines; Quaternary Ammonium Compounds; Rabbits; Stereoisomerism; Torsades de Pointes | 1992 |
Relaxant effects of BRL 38227 and pinacidil on the rat gastric fundus.
Topics: Animals; Benzopyrans; Cromakalim; Dose-Response Relationship, Drug; Female; Gastric Fundus; Glyburide; Guanidines; In Vitro Techniques; Male; Muscle Relaxation; Phentolamine; Pinacidil; Potassium Channels; Pyrroles; Rats; Vasodilator Agents | 1992 |
The binding site for [3H]glibenclamide in the rat cerebral cortex does not recognize K-channel agonists or antagonists other than sulphonylureas.
Topics: Animals; Benzopyrans; Binding Sites; Calcium Channels; Cerebral Cortex; Cromakalim; Glyburide; Guanidines; In Vitro Techniques; Kinetics; Male; Membranes; Pinacidil; Potassium Channels; Pyrroles; Rats; Rats, Inbred Strains; Sulfonylurea Compounds; Vasodilator Agents | 1991 |
Analysis and use of the perforated patch technique for recording ionic currents in pancreatic beta-cells.
Topics: Adenosine Triphosphate; Animals; Antihypertensive Agents; Biological Transport; Calcium; Calcium Channels; Cells, Cultured; Electric Conductivity; Glyburide; Guanidines; Ions; Islets of Langerhans; Male; Membrane Potentials; Nystatin; Pinacidil; Potassium; Potassium Channels; Rats; Rats, Inbred Strains; Time Factors | 1991 |
Pinacidil opens ATP-dependent K+ channels in cardiac myocytes in an ATP- and temperature-dependent manner.
Topics: Action Potentials; Adenosine Triphosphate; Animals; Dimethyl Sulfoxide; Glyburide; Guanidines; Guinea Pigs; In Vitro Techniques; Kinetics; Myocardium; Papillary Muscles; Pinacidil; Potassium Channels; Temperature | 1990 |
Selective inhibition of relaxation of guinea-pig trachea by charybdotoxin, a potent Ca(++)-activated K+ channel inhibitor.
Topics: Aminophylline; Animals; Benzopyrans; Calcium; Carbachol; Charybdotoxin; Cromakalim; Dose-Response Relationship, Drug; Glyburide; Guanidines; Guinea Pigs; In Vitro Techniques; Isoproterenol; Male; Muscle Relaxation; Nitroprusside; Pinacidil; Potassium Channels; Pyrroles; Scorpion Venoms; Serotonin; Trachea | 1990 |
Effects of porcine galanin on the mesenteric microcirculation and arteriolar smooth muscle in the rat.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Diphosphate; Agglutination; Animals; Arterioles; Erythrocytes; Galanin; Glyburide; Guanidines; In Vitro Techniques; Isometric Contraction; Male; Microcirculation; Muscle, Smooth, Vascular; Peptides; Pinacidil; Platelet Aggregation; Prostaglandin Endoperoxides, Synthetic; Rats; Rats, Inbred Strains; Splanchnic Circulation; Swine; Vasodilator Agents | 1991 |
Pulmonary vasodilator responses to RP 52891 are mediated by activation of a glibenclamide-sensitive K+ATP channel.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Acetylcholine; Adenosine Triphosphate; Animals; Benzopyrans; Blood Gas Analysis; Blood Pressure; Cats; Cromakalim; Female; Glyburide; Guanidines; Hydrogen-Ion Concentration; Isoproterenol; Male; Nitroprusside; Picolines; Pinacidil; Potassium Channels; Prostaglandin Endoperoxides, Synthetic; Pulmonary Circulation; Pyrans; Pyrroles; Vasodilation; Vasodilator Agents | 1991 |
Guanosine diphosphate activates an adenosine 5'-triphosphate-sensitive K+ channel in the rabbit portal vein.
Topics: Adenosine Triphosphate; Animals; Calcium; Glyburide; Guanidines; Guanosine Diphosphate; Ion Channel Gating; Membrane Potentials; Muscle, Smooth, Vascular; Pinacidil; Portal Vein; Potassium Channels; Rabbits | 1991 |
Analysis of pulmonary and systemic vascular responses to cromakalim, an activator of K+ATP channels.
Topics: Adenosine Triphosphate; Animals; Antihypertensive Agents; Benzopyrans; Blood Circulation; Cats; Cromakalim; Endothelins; Glyburide; Guanidines; Heart Rate; Hindlimb; Myocardial Contraction; Niacinamide; Nicorandil; Pinacidil; Potassium Channels; Pulmonary Circulation; Pyrroles; Vascular Resistance; Vasodilator Agents; Ventricular Function, Right | 1991 |
Differential antagonism by glibenclamide of the relaxant effects of cromakalim, pinacidil and nicorandil on canine large coronary arteries.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Arteries; Benzopyrans; Coronary Vessels; Cromakalim; Dogs; Dose-Response Relationship, Drug; Female; Glyburide; Guanidines; Male; Methylene Blue; Muscle Contraction; Muscle, Smooth, Vascular; Niacinamide; Nicorandil; Nitroglycerin; Pinacidil; Potassium; Prostaglandin Endoperoxides, Synthetic; Pyrroles; Vasodilator Agents | 1991 |
Analysis of cromakalim-, pinacidil-, and nicorandil-induced relaxation of the 5-hydroxytryptamine precontracted rat isolated basilar artery.
Topics: Animals; Basilar Artery; Benzopyrans; Cromakalim; Drug Interactions; Glyburide; Guanidines; Male; Muscle, Smooth, Vascular; Niacinamide; Nicorandil; Pinacidil; Potassium Channels; Pyrroles; Rats; Rats, Inbred Strains; Serotonin; Serotonin Antagonists; Vasoconstriction; Vasodilation; Vasodilator Agents | 1991 |
Chiral recognition of pinacidil and its 3-pyridyl isomer by canine cardiac and smooth muscle: antagonism by sulfonylureas.
Topics: Adenosine Triphosphate; Animals; Dogs; Dose-Response Relationship, Drug; Female; Glipizide; Glyburide; Guanidines; Heart; Male; Muscle Relaxation; Muscle, Smooth, Vascular; Phenylephrine; Pinacidil; Potassium Channels; Purkinje Fibers; Rubidium Radioisotopes; Stereoisomerism; Sulfonylurea Compounds; Vasodilator Agents | 1991 |
Quantitative autoradiography of the binding sites for [125I] iodoglyburide, a novel high-affinity ligand for ATP-sensitive potassium channels in rat brain.
Topics: Affinity Labels; Animals; Autoradiography; Binding Sites; Brain; Glipizide; Glyburide; Guanidines; Iodine Radioisotopes; Male; Pinacidil; Potassium Channels; Rats; Rats, Inbred Strains; Vasodilator Agents | 1991 |
Metabolic correlates to pacemaker activity in the smooth muscle of guinea-pig mesotubarium.
Topics: Adenosine Triphosphate; Animals; Biological Clocks; Biological Transport, Active; Felodipine; Female; Glyburide; Glycolysis; Guanidines; Guinea Pigs; Lactates; Membrane Potentials; Muscle Contraction; Muscle, Smooth; Ouabain; Ovary; Oxidation-Reduction; Oxygen Consumption; Pinacidil; Potassium; Potassium Channels; Sodium; Uterus; Vasodilator Agents | 1991 |
Hyperpolarization of arterial smooth muscle induced by endothelial humoral substances.
Topics: Acetylcholine; Action Potentials; Animals; Antihypertensive Agents; Biological Factors; Carotid Arteries; Coronary Vessels; Electric Conductivity; Endothelium, Vascular; Female; Glyburide; Guanidines; Guinea Pigs; Male; Membrane Potentials; Muscle, Smooth, Vascular; Pinacidil; Tetraethylammonium Compounds | 1991 |
Pinacidil inhibits the ryanodine-sensitive outward current and glibenclamide antagonizes its action in cells from the rabbit portal vein.
Topics: Adenosine Triphosphate; Animals; Calcium; Glyburide; Guanidines; In Vitro Techniques; Muscle, Smooth, Vascular; Pinacidil; Portal Vein; Potassium Channels; Rabbits; Ryanodine; Vasodilator Agents | 1991 |
ATP-regulated K+ channels protect the myocardium against ischemia/reperfusion damage.
Topics: Action Potentials; Adenosine Triphosphate; Animals; Coronary Disease; Glyburide; Guanidines; Guinea Pigs; Heart; In Vitro Techniques; Membrane Potentials; Myocardial Reperfusion Injury; Perfusion; Pinacidil; Potassium Channels | 1991 |
Cromakalim and pinacidil dilate small mesenteric arteries but not small cerebral arteries.
Topics: Animals; Benzopyrans; Cerebral Arteries; Cromakalim; Glyburide; Guanidines; Male; Mesenteric Arteries; Pinacidil; Potassium; Potassium Channels; Pyrroles; Rats; Rats, Inbred WKY; Vasodilation; Vasodilator Agents | 1991 |
Effects of ATP-sensitive K+ channel blockers on the action potential shortening in hypoxic and ischaemic myocardium.
Topics: Action Potentials; Adenosine Triphosphate; Animals; Coronary Circulation; Coronary Disease; Dogs; Female; Glyburide; Guanidines; Guinea Pigs; Hypoxia; In Vitro Techniques; Male; Myocardial Contraction; Papillary Muscles; Perfusion; Pinacidil; Potassium Channels; Sulfonylurea Compounds; Tolbutamide | 1991 |
Two different types of channels are targets for potassium channel openers in Xenopus oocytes.
Topics: Animals; Benzopyrans; Cromakalim; Electric Conductivity; Female; Glyburide; Guanidines; Oocytes; Organic Chemicals; Pinacidil; Potassium Channels; Pyrroles; Vasodilator Agents; Xenopus laevis | 1991 |
Glibenclamide blocks the relaxant action of pinacidil and cromakalim in airway smooth muscle.
Topics: Animals; Benzopyrans; Cromakalim; Female; Glyburide; Guanidines; Guinea Pigs; Histamine; In Vitro Techniques; Male; Muscle Relaxants, Central; Muscle Relaxation; Muscle, Smooth; Pinacidil; Pyrroles; Terbutaline; Theophylline; Trachea; Verapamil | 1990 |
Evidence that pinacidil may promote the opening of ATP-sensitive K+ channels yet inhibit the opening of Ca2(+)-activated K+ channels in K(+)-contracted canine mesenteric artery.
Topics: Adenosine Triphosphate; Animals; Benzopyrans; Calcium; Cromakalim; Dogs; Female; Glyburide; Guanidines; In Vitro Techniques; Male; Mesenteric Arteries; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Nifedipine; Pinacidil; Potassium; Potassium Channels; Pyrroles; Rubidium Radioisotopes | 1990 |
Characterization of responses to cromakalim and pinacidil in smooth and cardiac muscle by use of selective antagonists.
Topics: Animals; Aorta, Thoracic; Benzopyrans; Clonidine; Coronary Vessels; Cromakalim; Dogs; Electric Stimulation; Glyburide; Guanidines; Guinea Pigs; Heart; In Vitro Techniques; Isoproterenol; Muscle Contraction; Muscle, Smooth; Muscle, Smooth, Vascular; Myocardial Contraction; Phentolamine; Pinacidil; Potassium Channels; Pyrroles; Rats | 1990 |
Hypoglycemic sulfonylureas antagonize the effects of cromakalim and pinacidil on 86Rb fluxes and contractile activity in the rat aorta.
Topics: Animals; Aorta, Thoracic; Benzopyrans; Cromakalim; Glyburide; Guanidines; Hypoglycemic Agents; In Vitro Techniques; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Nitroprusside; Parasympatholytics; Pinacidil; Potassium Channels; Pyrroles; Rats; Rats, Inbred Strains; Rubidium Radioisotopes; Sulfonylurea Compounds; Tetraethylammonium Compounds; Tolbutamide; Vasodilator Agents | 1990 |
Effects of several potassium channel openers and glibenclamide on the uterus of the rat.
Topics: Animals; Benzopyrans; Blood Pressure; Cromakalim; Female; Glyburide; Guanidines; Heart Rate; Hemodynamics; In Vitro Techniques; Oxytocin; Parasympatholytics; Picolines; Pinacidil; Potassium Channels; Potassium Chloride; Pregnancy; Pyrans; Pyrroles; Rats; Rats, Inbred Strains; Uterus; Vasodilator Agents | 1990 |
Cytoplasmic calcium and the relaxation of canine coronary arterial smooth muscle produced by cromakalim, pinacidil and nicorandil.
Topics: Adenosine Triphosphate; Animals; Benzopyrans; Calcium; Coronary Vessels; Cromakalim; Cytoplasm; Dogs; Female; Fluorescence; Glyburide; Guanidines; In Vitro Techniques; Male; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Niacinamide; Nicorandil; Pinacidil; Potassium Chloride; Pyrroles; Quaternary Ammonium Compounds | 1990 |
Specific antagonism by glibenclamide of negative inotropic effects of potassium channel openers in canine atrial muscle.
Topics: Animals; Benzopyrans; Carbachol; Cromakalim; Dogs; Female; Glyburide; Guanidines; Heart Atria; Male; Myocardial Contraction; Niacinamide; Nicorandil; Nifedipine; Pinacidil; Potassium Channels; Pyrroles; Vasodilator Agents | 1990 |
Comparison of effects of cromakalim and pinacidil on mechanical activity and 86Rb efflux in dog coronary arteries.
Topics: Animals; Benzopyrans; Calcium Channels; Coronary Vessels; Cromakalim; Dogs; Female; Glyburide; Guanidines; Male; Muscle, Smooth, Vascular; Pinacidil; Potassium Channels; Pyrroles; Rubidium Radioisotopes; Vasoconstriction; Vasodilator Agents | 1990 |
Inhibition by sulphonylureas of vasorelaxation induced by K+ channel activators in vitro.
Topics: Animals; Antihypertensive Agents; Benzopyrans; Cromakalim; Drug Interactions; Glipizide; Glyburide; Guanidines; In Vitro Techniques; Male; Nifedipine; Norepinephrine; Pinacidil; Potassium Channels; Potassium Chloride; Pyrroles; Rabbits; Sulfonylurea Compounds; Tolbutamide; Vasodilator Agents | 1989 |
Hyperpolarizing vasodilators activate ATP-sensitive K+ channels in arterial smooth muscle.
Topics: Acetylcholine; Adenosine Triphosphate; Animals; Benzopyrans; Cerebral Arteries; Cromakalim; Diazoxide; Glyburide; Guanidines; Mesenteric Arteries; Muscle, Smooth, Vascular; Pinacidil; Potassium Channels; Pyrroles; Rabbits; Rats; Tolbutamide; Vasoactive Intestinal Peptide; Vasodilator Agents | 1989 |
Influence of ATP-sensitive potassium channel modulators on ischemia-induced fibrillation in isolated rat hearts.
Topics: Adenosine Triphosphate; Animals; Antihypertensive Agents; Arrhythmias, Cardiac; Benzopyrans; Coronary Circulation; Coronary Disease; Cromakalim; Glyburide; Guanidines; Heart; Heart Rate; In Vitro Techniques; Male; Perfusion; Pinacidil; Potassium Channels; Pyrroles; Rats; Rats, Inbred Strains; Tolbutamide; Vascular Resistance | 1989 |
Anti-ischemic effects of the potassium channel activators pinacidil and cromakalim and the reversal of these effects with the potassium channel blocker glyburide.
Topics: Animals; Antihypertensive Agents; Benzopyrans; Coronary Disease; Cromakalim; Glyburide; Guanidines; In Vitro Techniques; Male; Membrane Potentials; Pinacidil; Potassium Channels; Pyrroles; Rats; Rats, Inbred Strains | 1989 |
Potassium channel openers act through an activation of ATP-sensitive K+ channels in guinea-pig cardiac myocytes.
Topics: Adenosine Triphosphate; Animals; Benzopyrans; Cromakalim; Electrophysiology; Glyburide; Guanidines; Guinea Pigs; Heart; In Vitro Techniques; Ion Channel Gating; Muscle, Smooth, Vascular; Picolines; Pinacidil; Potassium Channels; Pyrans; Pyrroles; Subtraction Technique | 1989 |
Activation of ATP-sensitive K channels in heart cells by pinacidil: dependence on ATP.
Topics: Adenosine Triphosphate; Animals; Antihypertensive Agents; Cells, Cultured; Electric Conductivity; Female; Glyburide; Guanidines; Guinea Pigs; Heart; Heart Ventricles; Male; Pinacidil; Potassium Channels; Ventricular Function | 1989 |
Cromakalim, RP49356, pinacidil and minoxidil sulphate in the rat uterus and their antagonism by glibenclamide. Smooth Muscle Research Group.
Topics: Animals; Benzopyrans; Cromakalim; Female; Glyburide; Guanidines; In Vitro Techniques; Minoxidil; Parasympatholytics; Picolines; Pinacidil; Pyrans; Pyrroles; Rats; Rats, Inbred Strains; Uterine Contraction | 1989 |
Glibenclamide is a competitive antagonist of cromakalim, pinacidil and RP 49356 in guinea-pig pulmonary artery.
Topics: Animals; Benzopyrans; Cromakalim; Glyburide; Guanidines; Guinea Pigs; In Vitro Techniques; Male; Methylene Blue; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Niacinamide; Nicorandil; Picolines; Pinacidil; Potassium Channels; Potassium Chloride; Pulmonary Artery; Purinones; Pyrans; Pyrroles; Tetraethylammonium Compounds | 1989 |
Adenosine triphosphate-sensitive K+ channels mediate postcardioplegia coronary hyperemia.
Topics: Adenosine Triphosphate; Animals; Coronary Circulation; Coronary Vessels; Glyburide; Guanidines; Heart Arrest, Induced; Hyperemia; In Vitro Techniques; Microscopy, Video; Myocardial Reperfusion; Myocardium; Nitroprusside; Pinacidil; Potassium Channels; Swine; Vascular Resistance; Vasoconstriction; Vasodilator Agents | 1995 |
Role of calcium-activated K+ channels in vasodilation induced by nitroglycerine, acetylcholine and nitric oxide.
Topics: Acetylcholine; Adenosine Triphosphate; Animals; Calcium; Charybdotoxin; Colforsin; Drug Interactions; Glyburide; Guanidines; Mesenteric Arteries; Muscle Relaxation; Muscle, Smooth, Vascular; Nitric Oxide; Nitroglycerin; Norepinephrine; Peptides; Pinacidil; Potassium; Potassium Channels; Rabbits; Scorpion Venoms; Vasodilation; Vasodilator Agents | 1993 |
Effects of ATP-sensitive K+ channel openers on pacemaker activity in isolated single rabbit sino-atrial node cells.
Topics: Action Potentials; Adenosine Triphosphate; Animals; Benzopyrans; Cromakalim; Electrophysiology; Glyburide; Guanidines; Heart Rate; In Vitro Techniques; Niacinamide; Nicorandil; Pinacidil; Potassium Channels; Pyrroles; Rabbits; Sinoatrial Node; Vasodilator Agents | 1993 |
Effects of K+ channel openers on the vascular actions of human gamma globulin.
Topics: Animals; Diazoxide; gamma-Globulins; Glyburide; Guanidines; Humans; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth, Vascular; Norepinephrine; Pinacidil; Portal Vein; Potassium Channels; Rats; Rats, Wistar; Vasodilator Agents | 1994 |
Diverse actions of calcitonin gene-related peptide on intracellular free Ca2+ concentrations in UMR 106 osteoblastic cells.
Topics: Adenosine Triphosphate; Animals; Bone Neoplasms; Calcitonin; Calcitonin Gene-Related Peptide; Calcium; Colforsin; Dose-Response Relationship, Drug; Egtazic Acid; Fura-2; Glyburide; Guanidines; Osteoblasts; Osteosarcoma; Pinacidil; Potassium; Potassium Channels; Rats; Spectrometry, Fluorescence; Tumor Cells, Cultured; Vasodilator Agents | 1995 |
Antifibrillatory and profibrillatory actions of selected class I antiarrhythmic agents.
Topics: Adenosine Triphosphate; Animals; Anti-Arrhythmia Agents; Aprindine; Atrial Fibrillation; Blood Gas Analysis; Electrophysiology; Flecainide; Glyburide; Guanidines; In Vitro Techniques; Lidocaine; Male; Myocardial Contraction; Pinacidil; Potassium Channels; Quinidine; Rabbits; Refractory Period, Electrophysiological; Vasodilator Agents | 1993 |
Single-channel properties and regulation of pinacidil/glibenclamide-sensitive K+ channels in follicular cells from Xenopus oocyte.
Topics: Acetylcholine; Adenosine Triphosphate; Animals; Calcium; Charybdotoxin; Cyclic AMP; Electrophysiology; Female; Glyburide; Guanidines; Magnesium; Membrane Potentials; Oocytes; Pinacidil; Potassium Channels; Scorpion Venoms; Sulfonylurea Compounds; Tetradecanoylphorbol Acetate; Xenopus laevis | 1993 |
A comparison of the relaxant effects of pinacidil in rabbit renal and mesenteric artery.
Topics: Animals; Apamin; Female; Glyburide; Guanidines; In Vitro Techniques; Male; Mesenteric Arteries; Pinacidil; Potassium Channels; Rabbits; Renal Artery; Tetraethylammonium Compounds; Vasodilation; Vasodilator Agents | 1994 |
Activation by intracellular GDP, metabolic inhibition and pinacidil of a glibenclamide-sensitive K-channel in smooth muscle cells of rat mesenteric artery.
Topics: Animals; Deoxyglucose; Electrophysiology; Glyburide; Guanidines; Guanosine Diphosphate; Male; Mesenteric Arteries; Muscle Contraction; Muscle, Smooth, Vascular; Patch-Clamp Techniques; Pinacidil; Potassium Channels; Rabbits; Rats; Rats, Wistar; Sodium Cyanide; Uridine Diphosphate; Vasodilator Agents | 1995 |
Ischemic preconditioning attenuates capillary no-reflow induced by prolonged ischemia and reperfusion.
Topics: Adenosine Triphosphate; Animals; Capillaries; Dogs; Female; Glyburide; Guanidines; Male; Muscle, Skeletal; Myocardial Ischemia; Myocardial Reperfusion; Pinacidil; Potassium Channels; Regional Blood Flow; Time Factors; Vasodilator Agents | 1995 |
The effects of racemic, (+)- and (-)-pinacidil on the membrane potential of the rat aorta.
Topics: Animals; Aorta, Thoracic; Endothelium, Vascular; Glyburide; Guanidines; Isoproterenol; Male; Membrane Potentials; Pinacidil; Propanolamines; Rats; Rats, Wistar; Stereoisomerism; Vasodilator Agents | 1995 |
Endogenous adenosine mediates coronary vasodilation during exercise after K(ATP)+ channel blockade.
Topics: Adenosine; Animals; Coronary Circulation; Diastole; Dogs; Glyburide; Guanidines; Hemodynamics; Hyperemia; Muscle Contraction; Muscle, Smooth, Vascular; Myocardium; Nitroprusside; Oxygen Consumption; Physical Conditioning, Animal; Pinacidil; Potassium Channel Blockers; Purinergic P1 Receptor Antagonists; Systole; Theophylline; Vasodilation | 1995 |
Dilating effect of perivascularly applied potassium channel openers cromakalim and pinacidil in rat and cat pial arteries in situ.
Topics: Animals; Benzopyrans; Cats; Cerebral Arteries; Cromakalim; Female; Glyburide; Guanidines; Ion Channel Gating; Male; Pinacidil; Potassium Channels; Pyrroles; Rats; Rats, Sprague-Dawley; Vasodilator Agents | 1994 |
Modulation of adrenergic coronary vasoconstriction via ATP-sensitive potassium channel.
Topics: Adenosine; Adenosine Triphosphate; Animals; Calcitonin Gene-Related Peptide; Coronary Circulation; Dogs; Electric Stimulation; Glyburide; Guanidines; Neuropeptide Y; Nitric Oxide; Norepinephrine; Peptide Fragments; Pinacidil; Potassium Channels; Sympathetic Nervous System; Theophylline; Vascular Resistance; Vasoconstriction | 1995 |
Glibenclamide prevents coronary vasodilation induced by beta 1-adrenoceptor stimulation in dogs.
Topics: Adenosine Triphosphate; Adrenergic beta-Agonists; Animals; Bisoprolol; Coronary Circulation; Dogs; Ethanolamines; Female; Glyburide; Guanidines; Isoproterenol; Male; Myocardium; Oxygen Consumption; Pinacidil; Potassium Channels; Vasodilation; Vasodilator Agents | 1994 |
Propranolol antagonizes coronary artery relaxation by a potassium channel opener.
Topics: Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Animals; Biological Transport; Cattle; Colforsin; Coronary Vessels; Cyclic AMP; Drug Interactions; Glyburide; Guanidines; Guinea Pigs; In Vitro Techniques; Muscle Relaxation; Muscle, Smooth; Muscle, Smooth, Vascular; Nitroprusside; Pinacidil; Potassium Channels; Propranolol; Rubidium Radioisotopes; Trachea; Vasodilator Agents | 1994 |
Effect of potassium on the action of the KATP modulators cromakalim, pinacidil, or glibenclamide on arrhythmias in isolated perfused rat heart subjected to regional ischaemia.
Topics: Animals; Arrhythmias, Cardiac; Benzopyrans; Cromakalim; Glyburide; Guanidines; Heart; Heart Rate; Myocardial Ischemia; Myocardial Reperfusion Injury; Perfusion; Pinacidil; Potassium; Pyrroles; Rats; Rats, Sprague-Dawley; Vasodilator Agents | 1994 |
ATP sensitive potassium channels are involved in adenosine A2 receptor mediated coronary vasodilatation in the dog.
Topics: Acetylcholine; Adenosine; Adenosine Triphosphate; Adenosine-5'-(N-ethylcarboxamide); Animals; Colforsin; Coronary Circulation; Dogs; Dose-Response Relationship, Drug; Glyburide; Guanidines; Ion Channel Gating; Pinacidil; Potassium Channels; Purinergic P1 Receptor Antagonists; Receptors, Purinergic P2; Theophylline; Vasodilator Agents; Xanthines | 1994 |
Ketamine-xylazine anaesthesia permits a KATP channel antagonist to attenuate preconditioning in rabbit myocardium.
Topics: Animals; Glyburide; Guanidines; Ketamine; Myocardial Infarction; Myocardial Ischemia; Myocardium; Pinacidil; Potassium Channels; Purinergic P1 Receptor Antagonists; Rabbits; Theophylline; Vasodilator Agents; Xylazine | 1994 |
Comparative effects of the potassium channel openers cromakalim and pinacidil and the cromakalim analog U-89232 on isolated vascular and cardiac tissue.
Topics: Animals; Benzopyrans; Cromakalim; Dose-Response Relationship, Drug; Female; Glyburide; Guanidines; Male; Muscle Relaxation; Muscle, Smooth, Vascular; Myocardial Contraction; Pinacidil; Potassium Channels; Pyrroles; Rabbits; Vasodilator Agents | 1994 |
Effect of minoxidil sulfate and pinacidil on single potassium channel current in cultured human outer root sheath cells and dermal papilla cells.
Topics: Calcium; Cells, Cultured; Glyburide; Guanidines; Hair; Humans; Minoxidil; Pinacidil; Potassium Channels; Rubidium | 1994 |
ATP-sensitive K+ channel opener acts as a potent Cl- channel inhibitor in vascular smooth muscle cells.
Topics: Adenosine Triphosphate; Amines; Animals; Cell Line; Cell Membrane; Chloride Channels; Dose-Response Relationship, Drug; Electric Conductivity; Glyburide; Guanidines; Membrane Potentials; Muscle, Smooth, Vascular; Pinacidil; Potassium Channels; Quaternary Ammonium Compounds; Rabbits | 1994 |
Glibenclamide enhances but pinacidil reduces attenuation in sympathetic responsiveness after acute coronary artery occlusion.
Topics: Acute Disease; Animals; Arterial Occlusive Diseases; Coronary Vessels; Denervation; Dogs; Dose-Response Relationship, Drug; Electric Stimulation; Female; Glucose; Glyburide; Guanidines; Hemodynamics; Male; Myocardial Infarction; Pinacidil; Refractory Period, Electrophysiological; Sympathetic Nervous System | 1994 |
Cloning and functional expression of a rat heart KATP channel.
Topics: Adenosine Triphosphate; Amino Acid Sequence; Animals; Cell Line; Cloning, Molecular; Cricetinae; Glyburide; Guanidines; Humans; Ion Channel Gating; Membrane Potentials; Molecular Sequence Data; Myocardium; Organ Specificity; Pinacidil; Polymerase Chain Reaction; Potassium Channels; Rats; Sequence Homology, Amino Acid | 1994 |
Evidence against KATP channel involvement in adenosine receptor-mediated dilation of epicardial vessels.
Topics: Adenosine Triphosphate; Animals; Arteries; Coronary Vessels; Dogs; Electrophysiology; Glyburide; Guanidines; In Vitro Techniques; Membrane Potentials; Pericardium; Pinacidil; Potassium Channels; Receptors, Purinergic P1; Vasodilation; Vasodilator Agents | 1994 |
K+ channel activators, acute glucose tolerance and glibenclamide-induced hypoglycaemia in the hypertensive rat.
Topics: Administration, Oral; Animals; Antihypertensive Agents; Benzopyrans; Blood Glucose; Blood Pressure; Cromakalim; Diazoxide; Dose-Response Relationship, Drug; Glucose Tolerance Test; Glyburide; Guanidines; Hypertension; Hypoglycemia; Pinacidil; Potassium Channels; Pyrroles; Rats; Rats, Inbred SHR | 1994 |
Demonstration of glibenclamide-sensitive K+ fluxes in rat liver mitochondria.
Topics: Animals; Glyburide; Guanidines; Male; Membrane Potentials; Mitochondria, Liver; Oxygen; Pinacidil; Potassium; Potassium Channels; Rats; Rats, Wistar | 1993 |
Endogenous adenosine does not activate ATP-sensitive potassium channels in the hypoxic guinea pig ventricle in vivo.
Topics: Action Potentials; Adenosine; Adenosine Triphosphate; Animals; Cardiac Pacing, Artificial; Cell Hypoxia; Glyburide; Guanidines; Guinea Pigs; Heart Conduction System; Myocardium; Pinacidil; Potassium Channels; Purinergic P1 Receptor Antagonists; Receptors, Purinergic P1; Stereoisomerism; Theophylline | 1994 |
Phorbol ester-induced ventricular fibrillation in the Langendorff-perfused rabbit heart: antagonism by staurosporine and glibenclamide.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Diglycerides; Glyburide; Guanidines; Isoquinolines; Perfusion; Phorbol 12,13-Dibutyrate; Phorbol Esters; Phorbols; Pinacidil; Piperazines; Protein Kinase C; Rabbits; Staurosporine; Ventricular Fibrillation | 1993 |
ATP-sensitive potassium channels and skeletal muscle function in vitro.
Topics: Animals; Benzopyrans; Cromakalim; Electric Stimulation; Energy Metabolism; Gallamine Triethiodide; Glyburide; Guanidines; In Vitro Techniques; Ischemia; Male; Muscle Contraction; Muscles; Pinacidil; Potassium Channels; Pyridines; Pyrroles; Rats; Rats, Sprague-Dawley | 1993 |
Arteriolar tone is determined by activity of ATP-sensitive potassium channels.
Topics: Adenosine Triphosphate; Animals; Arterioles; Benzopyrans; Bucladesine; Colforsin; Cricetinae; Cromakalim; Epoprostenol; Glyburide; Guanidines; Isoproterenol; Male; Mesocricetus; Methacholine Chloride; Muscle Tonus; Muscle, Smooth, Vascular; Muscles; Nitroprusside; Pinacidil; Potassium Channels; Pyrroles; Quaternary Ammonium Compounds; Vasoconstriction; Vasodilation; Vasodilator Agents | 1993 |
Ischemic cardioprotection by ATP-sensitive K+ channels involves high-energy phosphate preservation.
Topics: Action Potentials; Adenosine Triphosphate; Animals; Glyburide; Guanidines; Guinea Pigs; Heart; In Vitro Techniques; Membrane Potentials; Myocardial Contraction; Myocardial Ischemia; Myocardium; Phosphocreatine; Pinacidil; Potassium Channels; Reperfusion Injury; Vasodilator Agents | 1993 |
Dilator effect of endothelins in pulmonary circulation: changes associated with chronic hypoxia.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Arginine; Autoradiography; Dose-Response Relationship, Drug; Endothelins; Glyburide; Guanidines; Hypoxia; In Vitro Techniques; Iodine Radioisotopes; Lung; Male; Meclofenamic Acid; Nitroarginine; Pentanoic Acids; Pinacidil; Potassium Channel Blockers; Prostaglandin Endoperoxides, Synthetic; Pulmonary Circulation; Pyridines; Rats; Rats, Wistar; Receptors, Endothelin; Tetraethylammonium; Tetraethylammonium Compounds; Thromboxane A2; Thromboxane-A Synthase; Vasoconstrictor Agents; Vasodilation; Vasodilator Agents | 1993 |
Relaxation by calcitonin gene-related peptide may involve activation of K+ channels in the human uterine artery.
Topics: Adenosine Triphosphate; Adult; Arteries; Calcitonin Gene-Related Peptide; Female; Glyburide; Guanidines; Humans; In Vitro Techniques; Pinacidil; Potassium Channel Blockers; Potassium Channels; Pregnancy; Tetraethylammonium; Tetraethylammonium Compounds; Uterus; Vasodilator Agents | 1993 |
Novel potassium channel openers: synthesis and pharmacological evaluation of new N-(substituted-3-pyridyl)-N'-alkylthioureas and related compounds.
Topics: 4-Aminopyridine; Amifampridine; Animals; Antihypertensive Agents; Biomechanical Phenomena; Glyburide; Guanidines; Hypertension; Male; Molecular Structure; Norbornanes; Pinacidil; Portal Vein; Potassium Channels; Rats; Rats, Inbred SHR; Rats, Wistar; Structure-Activity Relationship | 1994 |
Pharmacological properties of ATP-sensitive K+ channels in mammalian skeletal muscle cells.
Topics: Adenosine Triphosphate; Animals; Benzopyrans; Cromakalim; Electrophysiology; Glyburide; Guanidines; In Vitro Techniques; Mice; Muscles; Niacinamide; Nicorandil; Organic Chemicals; Pinacidil; Potassium Channels; Pyrroles; Vasodilator Agents | 1993 |
Comparative electrophysiological and mechanical actions of ATP-sensitive potassium channel openers in canine Purkinje fibers.
Topics: Action Potentials; Adenosine Triphosphate; Animals; Benzopyrans; Cromakalim; Dogs; Electrophysiology; Glyburide; Guanidines; In Vitro Techniques; Myocardial Contraction; Niacinamide; Nicorandil; Pinacidil; Potassium Channels; Purkinje Fibers; Pyrroles; Tetraethylammonium Compounds; Vasodilator Agents | 1993 |
Blockade of ATP-sensitive potassium channels increases infarct size but does not prevent preconditioning in rabbit hearts.
Topics: Animals; Female; Glyburide; Guanidines; Male; Myocardial Infarction; Myocardial Ischemia; Pinacidil; Potassium Channels; Proton Pump Inhibitors; Rabbits; Sodium-Potassium-Exchanging ATPase | 1993 |
Role of ATP-sensitive K+ channel on ECG ST segment elevation during a bout of myocardial ischemia. A study on epicardial mapping in dogs.
Topics: Action Potentials; Adenosine Triphosphate; Animals; Dogs; Electrocardiography; Glyburide; Guanidines; Heart Conduction System; Myocardial Ischemia; Pericardium; Pinacidil; Potassium Channels; Stereoisomerism; Vasodilator Agents | 1993 |
High affinity binding of a potassium channel agonist to intact rat insulinoma cells.
Topics: Animals; Aorta; Binding Sites; Binding, Competitive; Glyburide; Guanidines; Insulinoma; Kinetics; Male; Nitro Compounds; Phenylurea Compounds; Pinacidil; Potassium Channels; Rats; Tumor Cells, Cultured; Vasodilation | 1993 |
Relaxant effects of the potassium channel activators BRL 38227 and pinacidil on guinea-pig and human airway smooth muscle, and blockade of their effects by glibenclamide and BRL 31660.
Topics: Animals; Anti-Arrhythmia Agents; Benzopyrans; Bronchi; Cromakalim; Female; Glyburide; Guanidines; Guinea Pigs; Histamine; Humans; In Vitro Techniques; Male; Muscle Relaxation; Muscle, Smooth; Pinacidil; Potassium; Potassium Channels; Potassium Radioisotopes; Pyrroles; Pyrrolidines; Respiratory System; Trachea; Vasodilator Agents | 1993 |
Mechanosensitive gating of atrial ATP-sensitive potassium channels.
Topics: Adenosine Triphosphate; Animals; Electrophysiology; Glyburide; Guanidines; Heart Atria; Ion Channel Gating; Myocardium; Pinacidil; Potassium Channels; Pressure; Rats; Rats, Wistar; Tolbutamide | 1993 |
Modulation of rabbit aortic Ca(2+)-activated K+ channels by pinacidil, cromakalim, and glibenclamide.
Topics: Animals; Aorta; Benzopyrans; Calcium; Cations; Cromakalim; Dose-Response Relationship, Drug; Glyburide; Guanidines; Lipid Bilayers; Membrane Potentials; Microsomes; Muscle, Smooth, Vascular; Pinacidil; Potassium Channels; Pyrroles; Rabbits; Vasodilator Agents | 1993 |
Potassium channel openers attenuate atrioventricular block by bupivacaine in isolated hearts.
Topics: Animals; Benzopyrans; Bupivacaine; Dihydropyridines; Glyburide; Guanidines; Guinea Pigs; Heart Block; In Vitro Techniques; Pinacidil; Potassium Channels; Vasodilator Agents | 1993 |
Potassium channels and preconditioning of isolated rabbit cardiomyocytes: effects of glyburide and pinacidil.
Topics: Analysis of Variance; Animals; Cells, Cultured; Glyburide; Guanidines; Heart; Hypoglycemic Agents; Kinetics; Myocardial Ischemia; Pinacidil; Potassium Channels; Purinergic P1 Receptor Antagonists; Rabbits; Time Factors; Vasodilator Agents; Xanthines | 1995 |
Hypoxic relaxation in functionally intact cattle coronary artery segments involves K+ ATP channels.
Topics: Adenosine; Adenosine Triphosphate; Animals; Arteries; Calcium; Calcium Channel Blockers; Cattle; Coronary Vessels; Glyburide; Guanidines; Hypoxia; In Vitro Techniques; Indomethacin; Muscle Relaxation; Pinacidil; Potassium Channel Blockers; Potassium Channels; Rabbits; Tetrodotoxin; Vasodilator Agents | 1995 |
Role of K+ ATP channels and adenosine in the regulation of coronary blood flow during exercise with normal and restricted coronary blood flow.
Topics: Adenosine; Animals; Coronary Circulation; Dogs; Glyburide; Guanidines; Hemodynamics; Myocardial Contraction; Physical Exertion; Pinacidil; Potassium Channel Blockers; Potassium Channels; Purinergic P1 Receptor Antagonists; Theophylline; Vasodilator Agents | 1996 |
Evidence against the association of the sulphonylurea receptor with endogenous Kir family members other than KATP in coronary vascular smooth muscle.
Topics: Adenosine Triphosphate; Animals; Arteries; ATP-Binding Cassette Transporters; Barium; Coronary Vessels; Glyburide; Guanidines; Muscle, Smooth, Vascular; Patch-Clamp Techniques; Pinacidil; Potassium Channels; Potassium Channels, Inwardly Rectifying; Receptors, Drug; Sulfonylurea Receptors; Swine | 1996 |
ATP-sensitive potassium channel modulators: both pinacidil and glibenclamide produce antiarrhythmic activity during acute myocardial infarction in conscious rats.
Topics: Adenosine Triphosphate; Animals; Glyburide; Guanidines; Kinetics; Male; Myocardial Infarction; Pinacidil; Potassium Channels; Rats; Rats, Sprague-Dawley; Vasodilator Agents | 1996 |
Coronary vascular ATP-sensitive potassium channels are activated to a greater extent in spontaneously hypertensive rats than in Wistar-Kyoto rats.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Triphosphate; Animals; Coronary Circulation; Coronary Vessels; Glyburide; Guanidines; Hypertension; Hypertrophy, Left Ventricular; Male; Myocardium; Organ Size; Oxygen Consumption; Pinacidil; Potassium Channel Blockers; Potassium Channels; Prostaglandin Endoperoxides, Synthetic; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Thromboxane A2; Vasoconstrictor Agents; Vasodilator Agents | 1996 |
Two types of ATP-sensitive potassium channels in rat portal vein smooth muscle cells.
Topics: Adenosine Triphosphate; Animals; Benzopyrans; Cells, Cultured; Cromakalim; Glyburide; Guanidines; Male; Membrane Potentials; Muscle, Smooth, Vascular; Pinacidil; Portal Vein; Potassium Channels; Pyrroles; Rats; Rats, Wistar; Sensitivity and Specificity; Uridine Diphosphate | 1996 |
Cerebral adenosine triphosphate-sensitive K+ channels may be impaired during acute cerebral ischemia in spontaneously hypertensive rats.
Topics: Adenosine Triphosphate; Adrenergic alpha-Antagonists; Animals; Antidiuretic Hormone Receptor Antagonists; Antihypertensive Agents; Arginine Vasopressin; Arterial Occlusive Diseases; Blood Pressure; Brain Ischemia; Carotid Arteries; Cerebral Cortex; Glyburide; Guanidines; Hypertension; Hypoglycemic Agents; Injections, Intravenous; Injections, Intraventricular; Ligation; Male; Pinacidil; Piperidines; Potassium Channels; Quinolones; Rats; Rats, Inbred SHR; Rats, Inbred WKY | 1996 |
Effects of cromakalim, pinacidil and glibenclamide on cholinergic transmission in rat isolated atria.
Topics: Acetylcholine; Analysis of Variance; Animals; Benzopyrans; Cholinergic Fibers; Cromakalim; Female; Glyburide; Guanidines; Heart; Hypoglycemic Agents; Male; Pinacidil; Potassium Channels; Pyrroles; Rats; Rats, Sprague-Dawley; Vasodilator Agents | 1995 |
The effects of pharmacological modulation of KATP on the guinea-pig isolated diaphragm.
Topics: Adenosine Triphosphate; Animals; Benzopyrans; Cromakalim; Diaphragm; Electrophysiology; Glyburide; Guanidines; Guinea Pigs; Indoles; Male; Membrane Potentials; Muscle Contraction; Muscle Tonus; Phentolamine; Pinacidil; Potassium Channels; Pyrroles | 1996 |
Identification and properties of an ATP-sensitive K+ current in rabbit sino-atrial node pacemaker cells.
Topics: Action Potentials; Adenosine Triphosphate; Animals; Benzopyrans; Cromakalim; Glyburide; Guanidines; Hydrogen-Ion Concentration; Kinetics; Myocardium; Patch-Clamp Techniques; Pinacidil; Potassium; Potassium Channel Blockers; Potassium Channels; Pyrroles; Rabbits; Sinoatrial Node; Sodium Cyanide; Vasodilator Agents | 1996 |
Postjunctional effect of pinacidil on contractility of isolated bovine trachealis.
Topics: Acetylcholine; Animals; Cattle; Cell Membrane; Dose-Response Relationship, Drug; Electric Stimulation; Glyburide; Guanidines; Histamine; Muscle Contraction; Muscle Relaxation; Muscle, Smooth; Pinacidil; Potassium Channels; Receptors, Neurotransmitter; Stereoisomerism; Trachea | 1996 |
Synthesis and structure-activity relationships of novel phenylcyanoguanidine derivatives as potassium channel openers.
Topics: Animals; Blood Pressure; Glyburide; Guanidines; Guinea Pigs; Heart Rate; Hypoglycemic Agents; Ileum; In Vitro Techniques; Magnetic Resonance Spectroscopy; Male; Muscle Relaxation; Muscle, Smooth; Pinacidil; Potassium Channels; Rats; Rats, Inbred SHR; Structure-Activity Relationship; Vasodilator Agents | 1996 |
Nonspecific inhibition of adenosine-activated K+ current by glibenclamide in guinea pig atrial myocytes.
Topics: Action Potentials; Adenosine; Animals; Atrial Function; Carbachol; Electric Conductivity; Glyburide; Guanidines; Guanosine 5'-O-(3-Thiotriphosphate); Guinea Pigs; Myocardium; Pinacidil; Potassium; Reaction Time | 1996 |
Effect of potassium channel modulators on male sexual behavior.
Topics: Animals; Female; Glyburide; Guanidines; Injections, Intraventricular; Male; Pinacidil; Potassium Channel Blockers; Potassium Channels; Rats; Rats, Sprague-Dawley; Sexual Behavior, Animal | 1997 |
Myocardial protection in the acutely injured heart: hyperpolarizing versus depolarizing hypothermic cardioplegia.
Topics: Animals; Cardioplegic Solutions; Coronary Circulation; Disease Models, Animal; Female; Glucose; Glyburide; Guanidines; Heart; Heart Arrest, Induced; Hypoglycemic Agents; Hypothermia, Induced; Ion Channel Gating; Male; Models, Cardiovascular; Pinacidil; Potassium Channels; Rabbits; Tromethamine; Vasodilator Agents | 1997 |
Sulphonylurea receptor 2B and Kir6.1 form a sulphonylurea-sensitive but ATP-insensitive K+ channel.
Topics: Adenosine Triphosphate; Animals; ATP-Binding Cassette Transporters; Cloning, Molecular; Glyburide; Guanidines; Guanosine Diphosphate; Guanosine Triphosphate; Hypoglycemic Agents; KATP Channels; Macromolecular Substances; Magnesium; Mice; Molecular Sequence Data; Muscle, Smooth, Vascular; Niacinamide; Nicorandil; Patch-Clamp Techniques; Pinacidil; Potassium Channels; Potassium Channels, Inwardly Rectifying; Receptors, Drug; Sulfonylurea Compounds; Sulfonylurea Receptors; Uridine Diphosphate; Vasodilator Agents | 1997 |
KATP channel modulators increase survival rate during coronary occlusion-reperfusion in anaesthetized rats.
Topics: Action Potentials; Adenosine Triphosphate; Analysis of Variance; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Benzopyrans; Blood Pressure; Calcium Channel Blockers; Coronary Disease; Cromakalim; Disease Models, Animal; Dose-Response Relationship, Drug; Electrocardiography; Glyburide; Guanidines; Heart Rate; Male; Myocardial Reperfusion Injury; Pinacidil; Potassium Channels; Pyrroles; Rats; Rats, Sprague-Dawley; Survival Rate; Vasodilator Agents; Ventricular Fibrillation | 1997 |
Hypoxia-induced catecholamine release and intracellular Ca2+ increase via suppression of K+ channels in cultured rat adrenal chromaffin cells.
Topics: Animals; Benzopyrans; Buffers; Calcium; Carotid Body; Catecholamines; Cell Hypoxia; CHO Cells; Chromaffin Cells; Cricetinae; Cromakalim; Diazoxide; Glioma; Glyburide; Guanidines; Hybrid Cells; Hypoglycemic Agents; Male; Membrane Potentials; Minoxidil; Neuroblastoma; Parasympatholytics; Patch-Clamp Techniques; Pinacidil; Potassium; Potassium Channel Blockers; Potassium Channels; Pyrroles; Rats; Rats, Wistar; Vasodilator Agents | 1997 |
Glibenclamide suppresses stretch-activated ANP secretion: involvements of K+ATP channels and L-type Ca2+ channel modulation.
Topics: Adenosine Triphosphate; Animals; Atrial Function; Atrial Natriuretic Factor; Calcium; Calcium Channel Blockers; Calcium Channels; Diltiazem; Extracellular Space; Female; Glyburide; Guanidines; In Vitro Techniques; Myocardial Contraction; Myocardium; Osmolar Concentration; Pinacidil; Potassium Channels; Rats; Rats, Sprague-Dawley | 1997 |
Transforming growth factor beta constricts rat cremaster arterioles.
Topics: Acetylcholine; Adenosine; Animals; Arachidonic Acid; Arterioles; Enzyme Inhibitors; Glyburide; Guanidines; Male; Meclofenamic Acid; Micromanipulation; Muscle, Skeletal; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitroprusside; Pinacidil; Potassium Channels; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Transforming Growth Factor beta; Vasoconstriction; Vasoconstrictor Agents | 1997 |
Effects of pinacidil on K+ channels in human coronary artery vascular smooth muscle cells.
Topics: Animals; Cardiomyopathy, Dilated; Coronary Vessels; Electric Conductivity; Glyburide; Guanidines; Humans; Membrane Potentials; Muscle, Smooth, Vascular; Peptides; Pinacidil; Potassium Channels; Potassium Channels, Inwardly Rectifying; Scorpion Venoms; Swine; Time Factors; Vasodilator Agents | 1997 |
K(ATP) channels do not mediate vasodilation by 3-morpholinosydnonimine in goat coronary artery.
Topics: Adenosine Triphosphate; Animals; Coronary Vessels; Glyburide; Goats; Guanidines; Hypoglycemic Agents; In Vitro Techniques; Molsidomine; Muscle, Smooth, Vascular; Pinacidil; Potassium; Potassium Channels; Tetraethylammonium; Tetraethylammonium Compounds; Vasodilation; Vasodilator Agents | 1997 |
Channel activators regulate ATP-sensitive potassium channel (KIR6.1) expression in chick cardiomyocytes.
Topics: Adenosine Triphosphate; Amino Acid Sequence; Animals; Binding, Competitive; Chick Embryo; Cloning, Molecular; Gene Expression Regulation; Glyburide; Guanidines; Immunoblotting; Molecular Sequence Data; Myocardium; Pinacidil; Polymerase Chain Reaction; Potassium Channels; Potassium Channels, Inwardly Rectifying; RNA, Messenger; Signal Transduction | 1997 |
Hyperpolarization of isolated capillaries from guinea-pig heart induced by K+ channel openers and glucose deprivation.
Topics: Adenosine Triphosphate; Animals; Barbiturates; Capillaries; Chromans; Coronary Circulation; Diazoxide; Fluorescent Dyes; Glucose; Glyburide; Gramicidin; Guanidines; Guinea Pigs; In Vitro Techniques; Isoxazoles; Membrane Potentials; Muscle, Smooth, Vascular; Osmolar Concentration; Pinacidil; Potassium; Potassium Channels; Pyrrolidines; Sodium Chloride; Vasodilator Agents | 1997 |
Binding and effects of KATP channel openers in the vascular smooth muscle cell line, A10.
Topics: Animals; Aorta, Thoracic; Binding, Competitive; Cell Line; Cromakalim; Glyburide; Guanidines; Membrane Potentials; Minoxidil; Muscle, Smooth, Vascular; Patch-Clamp Techniques; Pinacidil; Potassium Channel Blockers; Potassium Channels; Pyridines; Radioligand Assay; Rats; Vasodilator Agents | 1997 |
The effects of levcromakalim and pinacidil on the human internal mammary artery.
Topics: 4-Aminopyridine; Adenosine Triphosphate; Apamin; Charybdotoxin; Coronary Artery Bypass; Coronary Disease; Cromakalim; Dose-Response Relationship, Drug; Glyburide; Guanidines; Humans; In Vitro Techniques; Male; Mammary Arteries; Muscle Relaxation; Muscle, Smooth, Vascular; Pinacidil; Potassium Channels; Tetraethylammonium; Vasodilation; Vasodilator Agents | 1997 |
Inhibitors of nitric oxide synthesis and ischemia/reperfusion attenuate coronary vasodilator response to pinacidil in isolated rat heart.
Topics: Animals; Coronary Vessels; Glyburide; Guanidines; Heart; In Vitro Techniques; Male; Myocardial Reperfusion Injury; Nitric Oxide; Nitroarginine; Pinacidil; Potassium Channels; Rats; Rats, Wistar; Vasodilator Agents | 1997 |
Temperature-sensitive effects of potassium channel openers on isolated guinea pig myocardium and aorta.
Topics: Action Potentials; Adenosine Triphosphate; Animals; Aorta, Thoracic; Cromakalim; Dose-Response Relationship, Drug; Endothelium, Vascular; Glyburide; Guanidines; Guinea Pigs; Heart Ventricles; In Vitro Techniques; Muscle, Smooth, Vascular; Myocardium; Norepinephrine; Oxadiazoles; Patch-Clamp Techniques; Pinacidil; Piperidines; Potassium Channels; Temperature; Vasodilator Agents | 1998 |
Proarrhythmic effects of pinacidil are partially mediated through enhancement of catecholamine release in isolated perfused guinea-pig hearts.
Topics: Adenosine Triphosphate; Adrenergic Agonists; Adrenergic beta-Antagonists; Animals; Arrhythmias, Cardiac; Epinephrine; Fluoxetine; Glyburide; Guanidines; Guinea Pigs; Heart; In Vitro Techniques; Isoproterenol; Methoxamine; Myocardial Reperfusion Injury; Myocardium; Nadolol; Norepinephrine; Perfusion; Pinacidil; Potassium Channels; Tyramine | 1998 |
Influence of potassium channel modulators on cognitive processes in mice.
Topics: Amnesia; Animals; Apamin; Avoidance Learning; Charybdotoxin; Cromakalim; Glyburide; Guanidines; Injections, Intraventricular; Male; Mice; Minoxidil; Pinacidil; Potassium Channels; Sulfonylurea Compounds; Tetraethylammonium | 1998 |
Activation of large-conductance potassium channels in pregnant human myometrium by pinacidil.
Topics: Calcium; Charybdotoxin; Electric Conductivity; Female; Glyburide; Guanidines; Humans; Muscle Relaxation; Myometrium; Pinacidil; Potassium Channels; Pregnancy; Spectrometry, Fluorescence; Uterine Contraction | 1998 |
Basal nitric oxide release differentially modulates vasodilations by pinacidil and levcromakalim in goat coronary artery.
Topics: Animals; Coronary Vessels; Cromakalim; Endothelium, Vascular; Enzyme Inhibitors; Glyburide; Goats; Guanidines; Hypoglycemic Agents; In Vitro Techniques; Methylene Blue; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Papaverine; Pinacidil; Potassium Channels; Vasodilation; Vasodilator Agents | 1998 |
Calcitonin gene-related peptide stimulates potassium efflux through adenosine triphosphate-sensitive potassium channels and produces membrane hyperpolarization in osteoblastic UMR106 cells.
Topics: Adenosine Triphosphate; Animals; Calcitonin Gene-Related Peptide; Colforsin; Enzyme Inhibitors; Glyburide; Guanidines; Isoquinolines; Membrane Potentials; Osteoblasts; Osteosarcoma; Pinacidil; Potassium; Potassium Channel Blockers; Potassium Channels; Protein Kinase Inhibitors; Rats; Sulfonamides; Tetraethylammonium; Tumor Cells, Cultured | 1998 |
Potassium channel openers require ATP to bind to and act through sulfonylurea receptors.
Topics: Adenosine Triphosphate; Animals; ATP-Binding Cassette Transporters; Binding Sites; Binding, Competitive; Cricetinae; Diazoxide; Glyburide; Guanidines; Humans; Mutation; Peptide Fragments; Pinacidil; Potassium Channels; Potassium Channels, Inwardly Rectifying; Protein Isoforms; Pyridines; Receptors, Drug; Recombinant Proteins; Sulfonylurea Receptors | 1998 |
Anoxia differentially modulates multiple K+ currents and depolarizes neonatal rat adrenal chromaffin cells.
Topics: Animals; Animals, Newborn; Chromaffin Cells; Electric Stimulation; Electrophysiology; Glyburide; Hypoglycemic Agents; Hypoxia; In Vitro Techniques; Membrane Potentials; Patch-Clamp Techniques; Pinacidil; Potassium Channels; Rats; Rats, Wistar; Tetrodotoxin | 1998 |
Potassium channel openers inhibit ATP-induced cytosolic free calcium increase in cultured rabbit aortic smooth muscle cells.
Topics: Adenosine Triphosphate; Animals; Aorta, Thoracic; Calcium; Cells, Cultured; Cromakalim; Glyburide; Muscle, Smooth, Vascular; Nicorandil; Pinacidil; Potassium Channels; Rabbits | 1996 |
The attenuated effect of ATP-sensitive K+ channel opener pinacidil on renal haemodynamics in spontaneously hypertensive rats.
Topics: Animals; Antihypertensive Agents; Glyburide; Hemodynamics; Hypoglycemic Agents; Kidney; Pinacidil; Potassium Channels; Punctures; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Species Specificity | 1998 |
Protein kinase C-dependent activation of KATP channel enhances adenosine-induced cardioprotection.
Topics: Adenosine; Animals; Cells, Cultured; Chick Embryo; Enzyme Activation; Glyburide; Ischemic Preconditioning, Myocardial; Myocardial Ischemia; Myocardium; Pinacidil; Potassium Channels; Protein Kinase C; Purinergic P1 Receptor Agonists; Receptor, Adenosine A3; Receptors, Purinergic P1; Tetradecanoylphorbol Acetate | 1998 |
Reconstituted human cardiac KATP channels: functional identity with the native channels from the sarcolemma of human ventricular cells.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Adolescent; Adult; Animals; ATP-Binding Cassette Transporters; Child; CHO Cells; Cloning, Molecular; COS Cells; Cricetinae; Cromakalim; Diazoxide; DNA, Complementary; Gene Library; Glyburide; Heart Ventricles; Humans; Magnesium; Middle Aged; Myocardium; Patch-Clamp Techniques; Pinacidil; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Inwardly Rectifying; Rats; Receptors, Drug; Sarcolemma; Sulfonylurea Receptors; Tolbutamide; Transfection | 1998 |
Coronary arteriolar dilation to acidosis: role of ATP-sensitive potassium channels and pertussis toxin-sensitive G proteins.
Topics: Acidosis; Adenosine Triphosphate; Animals; Arterioles; Coronary Vessels; Female; Glyburide; GTP-Binding Proteins; Hypoglycemic Agents; In Vitro Techniques; Male; Nitroprusside; Pertussis Toxin; Pinacidil; Potassium Channels; Signal Transduction; Swine; Vasodilation; Vasodilator Agents; Virulence Factors, Bordetella | 1999 |
Comparison of the vascular relaxant effects of ATP-dependent K+ channel openers on aorta and pulmonary artery isolated from spontaneously hypertensive and Wistar-Kyoto rats.
Topics: Adenosine Triphosphate; Aminoquinolines; Animals; Aorta, Thoracic; Apamin; Benzopyrans; Charybdotoxin; Cromakalim; Dose-Response Relationship, Drug; Glyburide; Hypertension; In Vitro Techniques; Male; Muscle Relaxation; Muscle, Smooth, Vascular; NG-Nitroarginine Methyl Ester; Nicorandil; Nitroprusside; Norepinephrine; Picolines; Pinacidil; Potassium; Potassium Channels; Pulmonary Artery; Pyrans; Pyrrolidinones; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Vasodilator Agents | 1999 |
ATP-sensitive potassium channel activation mimics the protective effect of ischaemic preconditioning in the rat isolated working heart after prolonged hypothermic storage.
Topics: Adenosine Triphosphate; Animals; Cardioplegic Solutions; Glyburide; Heart Rate; Hemodynamics; Hypoglycemic Agents; Ischemic Preconditioning, Myocardial; Male; Organ Preservation; Organ Preservation Solutions; Pinacidil; Potassium Channel Blockers; Potassium Channels; Rats; Rats, Wistar; Vasodilator Agents; Water | 1999 |
Differential effects of pinacidil, cromakalim, and NS 1619 on electrically evoked contractions in rat vas deferens.
Topics: Animals; Benzimidazoles; Charybdotoxin; Cromakalim; Electric Stimulation; Glyburide; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Pinacidil; Potassium Channels; Rats; Rats, Sprague-Dawley; Vas Deferens; Vasodilator Agents | 1997 |
Post-partum prolongation of the atrial repolarization in rabbit.
Topics: 4-Aminopyridine; Action Potentials; Animals; Atrial Function; Electrophysiology; Estrogens; Female; Glyburide; Heart Atria; Heart Conduction System; Hypoglycemic Agents; Muscle Fibers, Skeletal; Myocardium; Pinacidil; Postpartum Period; Potassium Channels; Pregnancy; Rabbits; Vasodilator Agents | 1999 |
Potentiation of quantal catecholamine secretion by glibenclamide: evidence for a novel role of sulphonylurea receptors in regulating the Ca(2+) sensitivity of exocytosis.
Topics: Animals; ATP-Binding Cassette Transporters; Caffeine; Calcium; Catecholamines; Cromakalim; Egtazic Acid; Electrochemistry; Exocytosis; Glyburide; Kinetics; Membrane Potentials; Patch-Clamp Techniques; PC12 Cells; Pinacidil; Potassium; Potassium Channels; Potassium Channels, Inwardly Rectifying; Quantum Theory; Rats; Receptors, Drug; Sulfonylurea Receptors; Tolbutamide | 1999 |
Protection of cardiomyocytes by pinacidil during metabolic inhibition and hyperkalemia.
Topics: Adenosine Triphosphate; Animals; Bepridil; Calcium; Calcium Channel Blockers; Cells, Cultured; Chick Embryo; Creatine Kinase; Glyburide; Homeostasis; Hyperkalemia; Myocardium; Pinacidil; Potassium Channels; Potassium Chloride; Sodium-Calcium Exchanger; Verapamil | 1999 |
Preconditioning improves cardioplegia-related coronary microvascular smooth muscle hypercontractility: role of KATP channels.
Topics: Animals; Calcium; Cardioplegic Solutions; Coronary Vasospasm; Coronary Vessels; Glyburide; Heart Arrest, Induced; Hypoglycemic Agents; In Vitro Techniques; Intracellular Fluid; Ischemic Preconditioning, Myocardial; Male; Muscle, Smooth, Vascular; Pinacidil; Potassium; Potassium Channels; Rats; Rats, Sprague-Dawley; Vasodilator Agents | 1999 |
Involvement of ATP-sensitive K(+) channels in spontaneous activity of isolated lymph microvessels in rats.
Topics: Adenosine Triphosphate; Animals; Glyburide; In Vitro Techniques; Lymphatic System; Male; Peptides; Pinacidil; Potassium Channel Blockers; Potassium Channels; Rats; Rats, Wistar; Tetraethylammonium | 1999 |
Differential effects of pinacidil and levcromakalim on the contractions elicited electrically or by noradrenaline in the portal vein of the rabbit.
Topics: Adrenergic alpha-Antagonists; Animals; Apamin; Charybdotoxin; Cromakalim; Dose-Response Relationship, Drug; Electric Stimulation; Female; Glyburide; In Vitro Techniques; Male; Norepinephrine; Pinacidil; Portal Vein; Potassium Channels; Rabbits; Tetrodotoxin; Vasoconstriction; Vasoconstrictor Agents; Vasodilator Agents | 1999 |
Troglitazone but not pioglitazone affects ATP-sensitive K(+) channel activity.
Topics: Adenosine Triphosphate; Animals; ATP-Binding Cassette Transporters; Chromans; COS Cells; Diazoxide; Electrophysiology; Glyburide; Membrane Potentials; Pinacidil; Pioglitazone; Potassium Channels; Potassium Channels, Inwardly Rectifying; Receptors, Drug; Recombinant Fusion Proteins; Rubidium Radioisotopes; Sulfonylurea Receptors; Thiazoles; Thiazolidinediones; Transfection; Troglitazone | 1999 |
Modulation of norepinephrine release by ATP-dependent K(+)-channel activators and inhibitors in guinea-pig and human isolated right atrium.
Topics: Adenosine; Adrenergic alpha-1 Receptor Agonists; Adrenergic alpha-2 Receptor Agonists; Analysis of Variance; Animals; Clonidine; Cromakalim; Decanoic Acids; Diazoxide; Dose-Response Relationship, Drug; Glyburide; Guinea Pigs; Heart Atria; Humans; Hydroxy Acids; In Vitro Techniques; Male; Muscarinic Agonists; Norepinephrine; Oxotremorine; Pinacidil; Potassium Channel Blockers; Potassium Channels; Stimulation, Chemical; Sympathetic Nervous System | 1999 |
Preconditioning reduces tissue complement gene expression in the rabbit isolated heart.
Topics: Animals; Complement System Proteins; DNA Primers; Gene Expression Regulation; Glyburide; In Vitro Techniques; Ischemic Preconditioning; Male; Myocardial Ischemia; Myocardial Reperfusion; Myocardium; Pinacidil; Potassium Channel Blockers; Potassium Channels; Rabbits; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Transcription, Genetic | 1999 |
Involvement of adenosine triphosphate-sensitive K+ channels in glucose-sensing in the rat solitary tract nucleus.
Topics: Adenosine Triphosphate; Animals; Blood Glucose; Diazoxide; Glyburide; Homeostasis; Hypoglycemia; Hypoglycemic Agents; Male; Nerve Tissue Proteins; Neurons; Pinacidil; Potassium Channels; Rats; Rats, Wistar; Solitary Nucleus; Tolbutamide | 2000 |
Vascular potassium channels mediate oxygen-induced pulmonary vasodilation in fetal lambs.
Topics: Animals; Blood Glucose; Enzyme Inhibitors; Female; Fetus; Glyburide; Hypoglycemic Agents; Lung; Muscle, Smooth, Vascular; Nitroarginine; Oxygen; Penicillamine; Pinacidil; Potassium Channels; Sheep; Tetraethylammonium; Vasodilation; Vasodilator Agents | 2000 |
Pinacidil suppresses contractility and preserves energy but glibenclamide has no effect during muscle fatigue.
Topics: Action Potentials; Adenosine Triphosphate; Animals; Energy Metabolism; Glyburide; Hypoglycemic Agents; Mice; Mice, Inbred Strains; Muscle Contraction; Muscle Fatigue; Muscle, Skeletal; Phosphocreatine; Pinacidil; Potassium Channels; Rubidium Radioisotopes; Vasodilator Agents | 2000 |
Blockade of cardiac ATP-sensitive K+ channel by cibenzoline targets its pore-forming subunit.
Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Antihypertensive Agents; Cell Membrane Permeability; Cells, Cultured; Drug Interactions; Electrophysiology; Female; Glyburide; Guinea Pigs; Heart Ventricles; Hydrogen-Ion Concentration; Hypoglycemic Agents; Imidazoles; Male; Patch-Clamp Techniques; Pinacidil; Potassium Channels | 2000 |
Evidence for mitochondrial K ATP channels as effectors of human myocardial preconditioning.
Topics: Analysis of Variance; Cell Membrane; Decanoic Acids; Diazoxide; Dose-Response Relationship, Drug; Glyburide; Heart; Humans; Hydroxy Acids; Hypoglycemic Agents; In Vitro Techniques; Ischemic Preconditioning, Myocardial; Mitochondria, Heart; Myocardial Ischemia; Pinacidil; Potassium Channel Blockers; Potassium Channels; Random Allocation; Sarcolemma; Sulfonamides; Thiourea | 2000 |
Pharmacology and modulation of K(ATP) channels by protein kinase C and phosphatases in gallbladder smooth muscle.
Topics: Adenosine Triphosphate; Animals; Diazoxide; Enzyme Activation; Female; Gallbladder; Glyburide; Guinea Pigs; Male; Muscle, Smooth; Muscle, Smooth, Vascular; Okadaic Acid; Phosphoric Monoester Hydrolases; Pinacidil; Potassium Channels; Protein Kinase C; Rats; Rats, Sprague-Dawley | 2000 |
Involvement of ATP-sensitive K(+) channels in the anti-tussive effect of moguisteine.
Topics: Animals; Antitussive Agents; ATP-Binding Cassette Transporters; Cough; Disease Models, Animal; Drug Interactions; Glyburide; Guinea Pigs; KATP Channels; Male; Pinacidil; Potassium Channels; Potassium Channels, Inwardly Rectifying; Thiazoles; Thiazolidines | 2000 |
K(ATP) channels mediate the beta(2)-adrenoceptor agonist-induced relaxation of rat detrusor muscle.
Topics: Adenosine Triphosphate; Adrenergic beta-Agonists; Animals; Clenbuterol; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Dose-Response Relationship, Drug; Electric Stimulation; Female; Glyburide; In Vitro Techniques; Male; Muscle Contraction; Muscle Relaxation; Muscle, Smooth; Pinacidil; Potassium Channels; Rats; Rats, Wistar; Urinary Bladder; Vasodilator Agents | 2000 |
KATP channels regulate mitogenically induced proliferation in primary rat hepatocytes and human liver cell lines. Implications for liver growth control and potential therapeutic targeting.
Topics: Animals; ATP-Binding Cassette Transporters; Calcium; Cell Division; Cells, Cultured; Cromakalim; DNA Replication; Electrophysiology; Glyburide; Humans; KATP Channels; Kinetics; Liver; Minoxidil; Mitogens; Pinacidil; Potassium Channels; Potassium Channels, Inwardly Rectifying; Quinidine; Rats; Reverse Transcriptase Polymerase Chain Reaction | 2000 |
Exaggerated impact of ATP-sensitive K(+) channels on afferent arteriolar diameter in diabetes mellitus.
Topics: Adenosine Triphosphate; Animals; Arterioles; Benzopyrans; Cyclopentanes; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Glyburide; Hypoglycemic Agents; Male; Pinacidil; Potassium Channel Blockers; Potassium Channels; Rats; Rats, Sprague-Dawley; Vasodilator Agents; Vasomotor System | 2000 |
Abnormal activation of K(+) channels in aortic smooth muscle of rats with endotoxic shock: electrophysiological and functional evidence.
Topics: Animals; Aorta; Apamin; Benzimidazoles; Charybdotoxin; Drug Interactions; Enzyme Inhibitors; Glyburide; Hypoglycemic Agents; Hypotension; Lipopolysaccharides; Male; Membrane Potentials; Muscle Relaxation; Muscle, Smooth, Vascular; NG-Nitroarginine Methyl Ester; Oxadiazoles; Pinacidil; Potassium Channels; Quinoxalines; Rats; Rats, Inbred WKY; Shock, Septic; Tetraethylammonium; Vasodilation; Vasodilator Agents | 2000 |
Effects of pinacidil on coronary Ca(2+)-myosin phosphorylation in cold potassium cardioplegia model.
Topics: Animals; Coronary Vessels; Dose-Response Relationship, Drug; Enzyme Inhibitors; Glyburide; Heart Arrest, Induced; Hypothermia, Induced; In Vitro Techniques; Male; Muscle, Smooth, Vascular; Myosin Light Chains; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Phosphorylation; Pinacidil; Potassium; Potassium Channel Blockers; Rats; Rats, Sprague-Dawley; Reperfusion; Vasodilator Agents | 2000 |
[The vasomotor effects of new fluorine-containing synthetic activators of ATP-dependent potassium channels].
Topics: Adenosine Triphosphate; Animals; Aorta; Dose-Response Relationship, Drug; Glyburide; Guinea Pigs; Hypoglycemic Agents; In Vitro Techniques; Pinacidil; Potassium Channel Blockers; Potassium Channels; Vascular Resistance; Vasodilator Agents; Vasomotor System | 2000 |
Inhibition of basolateral cAMP permeability in the toad urinary bladder.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Animals; ATP-Binding Cassette Transporters; Bufo marinus; Calcium Channel Blockers; Colforsin; Cyclic AMP; Dose-Response Relationship, Drug; Epithelium; Glyburide; In Vitro Techniques; Membrane Fluidity; ortho-Aminobenzoates; Osmosis; Permeability; Pinacidil; Potassium Channels; Potassium Channels, Inwardly Rectifying; Receptors, Drug; Sulfonylurea Receptors; Urinary Bladder; Vasodilator Agents; Vasopressins; Water | 2000 |
Hyperosmolality dilates rat skeletal muscle arterioles: role of endothelial K(ATP) channels and daily exercise.
Topics: Adenosine Triphosphate; Animals; Arterioles; Blood Glucose; Endothelium, Vascular; Glyburide; Hindlimb; In Vitro Techniques; Male; Motor Activity; Muscle, Skeletal; Osmolar Concentration; Physical Conditioning, Animal; Pinacidil; Potassium Channels; Rats; Rats, Wistar; Vasodilation | 2000 |
Role of potassium channels in regulation of brain arteriolar tone: comparison of cerebrum versus brain stem.
Topics: 4-Aminopyridine; Animals; Arterioles; Barium Compounds; Brain; Brain Stem; Chlorides; Dose-Response Relationship, Drug; Enzyme Inhibitors; Glyburide; Hydrogen-Ion Concentration; In Vitro Techniques; Male; Nitric Oxide Synthase; Nitroarginine; Pinacidil; Potassium; Potassium Channel Blockers; Potassium Channels; Rats; Rats, Sprague-Dawley; Telencephalon; Tetraethylammonium; Vasoconstriction; Vasodilator Agents | 2001 |
Pharmacological comparison of native mitochondrial K(ATP) channels with molecularly defined surface K(ATP) channels.
Topics: Animals; ATP-Binding Cassette Transporters; Cells, Cultured; Diazoxide; Glyburide; Guanidines; Heart Ventricles; Humans; KATP Channels; Membrane Proteins; Mitochondria, Heart; Myocardium; Patch-Clamp Techniques; Pinacidil; Potassium Channels; Potassium Channels, Inwardly Rectifying; Pyridines; Rabbits; Receptors, Drug; Recombinant Proteins; Sulfonylurea Receptors; Vasodilator Agents | 2001 |
Altered effects of potassium channel modulation in the coronary circulation in experimental hypercholesterolemia.
Topics: Adenosine Triphosphatases; Animals; Blood Flow Velocity; Cation Transport Proteins; Cholesterol; Cholesterol, Dietary; Coronary Circulation; Coronary Vessels; Enzyme Inhibitors; Female; Glyburide; Hypercholesterolemia; Hypoglycemic Agents; Injections, Intra-Arterial; omega-N-Methylarginine; Pinacidil; Potassium Channels; Swine; Vasodilator Agents | 2001 |
Activation of Na(+), K(+), Cl(-)-cotransport mediates intracellular Ca(2+) increase and apoptosis induced by Pinacidil in HepG2 human hepatoblastoma cells.
Topics: Adenosine Triphosphate; Amiloride; Apoptosis; Bepridil; Bumetanide; Calcium; Carrier Proteins; DNA Fragmentation; Dose-Response Relationship, Drug; Furosemide; Glyburide; Hepatoblastoma; Humans; Pinacidil; Potassium; Potassium Channel Blockers; Potassium Channels; Sodium; Sodium-Calcium Exchanger; Sodium-Potassium-Chloride Symporters; Time Factors; Tolbutamide; Tumor Cells, Cultured | 2001 |
Possible underestimation of the channel conductance underlying pinacidil-induced K+ currents using noise analysis in pig urethral myocytes.
Topics: Animals; Antihypertensive Agents; Electrophysiology; Female; Glyburide; Hypoglycemic Agents; Membrane Potentials; Patch-Clamp Techniques; Pinacidil; Potassium Channels; Swine; Urethra | 2000 |
Effects of K+ channel openers on I K(ATP) of human atrial myocytes at physiological temperatures.
Topics: Adenosine Triphosphate; Adult; Aged; Cromakalim; Female; Glyburide; Heart Atria; Humans; Hypoglycemic Agents; Male; Middle Aged; Pinacidil; Potassium Channels; Temperature; Vasodilator Agents | 2001 |
Functional roles of cardiac and vascular ATP-sensitive potassium channels clarified by Kir6.2-knockout mice.
Topics: Adenosine Triphosphate; Adenoviridae; Animals; Aorta; Blood Pressure; Blotting, Northern; Diazoxide; Dose-Response Relationship, Drug; Electrophysiology; Genetic Vectors; Genotype; Glyburide; Heart; Heart Rate; Heart Ventricles; In Vitro Techniques; Membrane Potentials; Mice; Mice, Inbred C57BL; Mice, Knockout; Muscle, Smooth, Vascular; Norepinephrine; Pinacidil; Potassium Channels; Potassium Channels, Inwardly Rectifying; RNA, Messenger; Transfection; Vasoconstriction; Vasodilator Agents; Ventricular Function | 2001 |
Levosimendan increases diastolic coronary flow in isolated guinea-pig heart by opening ATP-sensitive potassium channels.
Topics: Animals; Coronary Circulation; Female; Glyburide; Guinea Pigs; Heart; Heart Rate; Hydrazones; Hypoglycemic Agents; In Vitro Techniques; Male; Myocardial Contraction; Myocardium; Pinacidil; Potassium Channels; Pyridazines; Simendan; Vasodilator Agents | 2001 |
K(ATP) channel currents regulate membrane potential in freshly isolated human and rat bladder smooth muscle cells.
Topics: Animals; Anti-Arrhythmia Agents; Charybdotoxin; Glyburide; Humans; Membrane Potentials; Muscle, Smooth; Pinacidil; Potassium Channels; Rats; Urinary Bladder; Vasodilator Agents | 2001 |
Changes in electrical properties of detrusor smooth muscle in the STZ (streptozotocin)-diabetic rat.
Topics: Action Potentials; Animals; Anti-Bacterial Agents; Antihypertensive Agents; Diabetes Mellitus, Experimental; Glyburide; Hypoglycemic Agents; Membrane Potentials; Muscle, Smooth; Pinacidil; Rats; Rats, Inbred F344; Streptozocin; Urinary Bladder | 2001 |
Modulation of K+-evoked [3H]-noradrenaline release from rat and human brain slices by gabapentin: involvement of KATP channels.
Topics: Acetates; Amines; Animals; Anticonvulsants; Cyclohexanecarboxylic Acids; Dose-Response Relationship, Drug; Gabapentin; gamma-Aminobutyric Acid; Glyburide; Hippocampus; Humans; Hypoglycemic Agents; In Vitro Techniques; Male; Neocortex; Norepinephrine; Pinacidil; Potassium Channels; Potassium Chloride; Rats; Rats, Wistar; Retrospective Studies; Vasodilator Agents | 2001 |
Denervation enhances the physiological effects of the K(ATP) channel during fatigue in EDL and soleus muscle.
Topics: Adenosine Triphosphate; Animals; Female; Gene Expression; Glyburide; Hypoglycemic Agents; Mice; Mice, Inbred Strains; Muscle Contraction; Muscle Denervation; Muscle Fatigue; Muscle, Skeletal; Phosphocreatine; Pinacidil; Potassium Channels; Potassium Channels, Inwardly Rectifying; RNA, Messenger; Rubidium Radioisotopes; Vasodilator Agents | 2001 |
Adenosine activates ATP-sensitive K(+) currents in pericytes of rat retinal microvessels: role of A1 and A2a receptors.
Topics: Adenosine; Adenosine Triphosphate; Animals; Antimetabolites; Antimycin A; Eye Proteins; Glyburide; Iodoacetates; Ion Transport; Membrane Potentials; Microcirculation; Patch-Clamp Techniques; Pericytes; Pinacidil; Potassium; Potassium Channels; Rats; Receptor, Adenosine A2A; Receptors, Purinergic P1; Retinal Vessels; Vasodilation; Vasodilator Agents | 2001 |
Regulation of ATP-sensitive K(+) channels by protein kinase C in murine colonic myocytes.
Topics: Acetylcholine; Adenosine Triphosphate; Alkaloids; Animals; Benzophenanthridines; Colon; Enzyme Activation; Enzyme Inhibitors; Female; Glyburide; In Vitro Techniques; Isoenzymes; Kinetics; Male; Membrane Potentials; Mice; Mice, Inbred BALB C; Muscle, Smooth; Naphthalenes; Patch-Clamp Techniques; Phenanthridines; Phorbol 12,13-Dibutyrate; Pinacidil; Potassium Channels; Protein Kinase C; Protein Kinase C-epsilon | 2001 |
Sulfonylurea receptors inhibit the epithelial sodium channel (ENaC) by reducing surface expression.
Topics: Animals; ATP-Binding Cassette Transporters; Cystic Fibrosis Transmembrane Conductance Regulator; Diazoxide; Diuretics; Epithelial Sodium Channels; Glyburide; Hypoglycemic Agents; Oocytes; Patch-Clamp Techniques; Pinacidil; Potassium Channels; Potassium Channels, Inwardly Rectifying; Receptors, Drug; Sodium Channel Blockers; Sodium Channels; Sodium Chloride Symporter Inhibitors; Sulfonylurea Receptors; Time Factors; Tolbutamide; Vasodilator Agents; Xenopus laevis | 2001 |
Antisense knockdown of inducible nitric oxide synthase inhibits the relaxant effect of VIP in isolated smooth muscle cells of the mouse gastric fundus.
Topics: Amidines; Animals; Arginine; Benzylamines; Carbachol; Cell Size; DNA, Antisense; Enzyme Inhibitors; Female; Fluorescein-5-isothiocyanate; Gastric Fundus; Glyburide; In Vitro Techniques; Male; Mice; Mice, Inbred C57BL; Muscle Relaxation; Muscle, Smooth; Nitrates; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitrites; Nitroarginine; Pinacidil; Tumor Necrosis Factor-alpha; Vasoactive Intestinal Peptide; Vasodilator Agents | 2001 |
Influence of ATP-sensitive K+ channel modulation on the mechanical properties of diabetic myocardium.
Topics: Adenosine Triphosphate; Animals; Biomechanical Phenomena; Blood Glucose; Cromakalim; Depression, Chemical; Diabetes Mellitus, Experimental; Diabetic Angiopathies; Glyburide; Male; Myocardial Contraction; Pinacidil; Potassium Channels; Rats; Rats, Wistar; Vasodilator Agents | 2001 |
ATP-sensitive K(+) channels composed of Kir6.1 and SUR2B subunits in guinea pig gastric myocytes.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Animals; Anti-Arrhythmia Agents; ATP-Binding Cassette Transporters; Calcium; Female; Gene Expression; Glyburide; Guinea Pigs; Male; Muscle, Smooth; Patch-Clamp Techniques; Pinacidil; Potassium; Potassium Channels; Potassium Channels, Inwardly Rectifying; Receptors, Drug; Stomach; Sulfonylurea Receptors; Vasodilator Agents | 2002 |
Characterisation of the effects of potassium channel modulating agents on mouse intestinal smooth muscle.
Topics: Animals; Benzopyrans; Cromakalim; Cyclopentanes; Dose-Response Relationship, Drug; Drug Interactions; Electric Stimulation; Glyburide; Guanidines; Ileum; Male; Mice; Muscle, Smooth; Pinacidil; Potassium Channel Blockers; Potassium Channels; Potassium Cyanide; Vasodilator Agents | 2002 |
Pharmacological evidence for the activation of K(+) channels by diclofenac.
Topics: 4-Aminopyridine; Analgesics; Analgesics, Opioid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Apamin; Behavior, Animal; Charybdotoxin; Diclofenac; Dose-Response Relationship, Drug; Female; Formaldehyde; Glyburide; Hindlimb; Morphine; Pain; Pinacidil; Potassium Channel Blockers; Potassium Channels; Rats; Rats, Wistar; Tetraethylammonium; Tolbutamide | 2002 |
Isoflurane inhibits neutrophil-endothelium interactions in the coronary circulation: lack of a role for adenosine triphosphate-sensitive potassium channels.
Topics: Acetylcholine; Adenosine Triphosphate; Anesthetics, Inhalation; Animals; Arteries; Cell Adhesion; Coronary Vessels; Dogs; Dose-Response Relationship, Drug; Endothelium, Vascular; Glyburide; In Vitro Techniques; Isoflurane; Neutrophil Activation; Neutrophils; Nitroprusside; Pinacidil; Platelet Activating Factor; Potassium Channel Blockers; Potassium Channels; Superoxides; Vasoconstriction; Vasodilation; Vasodilator Agents | 2002 |
Opening of mitochondrial ATP-sensitive potassium channels evokes oxygen radical generation in rabbit heart slices.
Topics: Adenosine Triphosphate; Analysis of Variance; Animals; Cromakalim; Decanoic Acids; Dose-Response Relationship, Drug; Ferrous Compounds; Glyburide; Hydroxy Acids; Iron Chelating Agents; Linear Models; Malondialdehyde; Mitochondria, Heart; Myocardial Reperfusion; Myocardium; Pinacidil; Potassium Channels; Rabbits; Reaction Time; Reactive Oxygen Species | 2002 |
Effects of K(ATP) channel modulators on acetylcholine release from guinea-pig isolated atria and small intestine.
Topics: Acetylcholine; Animals; Atrial Function; Cromakalim; Diazoxide; Female; Glyburide; Guinea Pigs; Heart Atria; In Vitro Techniques; Intestine, Small; Male; Muscle, Smooth; Myenteric Plexus; Myocardial Contraction; Neuromuscular Junction; Pinacidil; Potassium Channel Blockers; Potassium Channels; Sulfonamides; Thiourea | 2002 |
Effect of adenosine triphosphate-sensitive potassium channel openers on lung preservation.
Topics: Adenosine Triphosphate; Animals; Disease Models, Animal; Glyburide; Hypertension, Pulmonary; Lung; Pinacidil; Potassium Channels; Pulmonary Wedge Pressure; Random Allocation; Rats; Rats, Inbred Lew; Reference Values; Reperfusion Injury; Sensitivity and Specificity | 2002 |
Potassium channels and human corporeal smooth muscle cell tone: diabetes and relaxation of human corpus cavernosum smooth muscle by adenosine triphosphate sensitive potassium channel openers.
Topics: Adenosine Triphosphate; Cromakalim; Culture Techniques; Dose-Response Relationship, Drug; Erectile Dysfunction; Glyburide; Humans; Male; Muscle, Smooth, Vascular; Penile Erection; Penis; Phenylephrine; Pinacidil; Potassium Channels; Vasodilation; Vasodilator Agents | 2002 |
Nicorandil inhibits degranulation and TNF-alpha release from RBL-2H3 cells.
Topics: Animals; beta-N-Acetylhexosaminidases; Calcium; Cell Degranulation; Cell Line; Cytoplasmic Granules; Cytosol; Dinitrophenols; Enzyme Inhibitors; Glyburide; Guanylate Cyclase; Hemoglobins; Indicators and Reagents; Mast Cells; Niacinamide; Nicorandil; Nitric Oxide; Nitric Oxide Donors; Pinacidil; Potassium; Potassium Channel Blockers; Potassium Channels; Rats; Tumor Necrosis Factor-alpha | 2002 |
D2-like receptor-mediated inhibition of Na+-K+-ATPase activity is dependent on the opening of K+ channels.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Amphotericin B; Animals; Antifungal Agents; Cardiotonic Agents; Cell Line; Dopamine; Dopamine Agonists; Dopamine Antagonists; Female; Glyburide; GTP-Binding Protein alpha Subunits, Gi-Go; Hypoglycemic Agents; Ion Channel Gating; Kidney; Opossums; Pertussis Toxin; Pinacidil; Potassium Channels; Quinolines; Receptors, Dopamine D2; Sodium; Sodium-Potassium-Exchanging ATPase; Sulpiride; Vasodilator Agents; Virulence Factors, Bordetella | 2002 |
Inhibitory effects of potassium channel blockers on tetramethylpyrazine-induced relaxation of rat aortic strip in vitro.
Topics: Animals; Aorta; Apamin; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; Endothelium, Vascular; Enzyme Inhibitors; Glyburide; Humans; In Vitro Techniques; Male; Oxadiazoles; Pinacidil; Potassium Channel Blockers; Potassium Channels; Pyrazines; Quinoxalines; Rats; Rats, Wistar; Vasoconstriction; Vasodilation; Vasodilator Agents | 2002 |
Inhaled pinacidil, an ATP-sensitive K+ channel opener, and moguisteine have potent antitussive effects in guinea pigs.
Topics: Adenosine Triphosphate; Administration, Inhalation; Animals; Antitussive Agents; Capsaicin; Codeine; Cough; Dose-Response Relationship, Drug; Drug Antagonism; Glyburide; Guinea Pigs; Male; Naloxone; Pinacidil; Potassium Channels; Thiazoles; Thiazolidines | 2002 |
Molecular basis of ATP-sensitive K+ channels in rat vascular smooth muscles.
Topics: Adenosine Triphosphate; Animals; Anti-Arrhythmia Agents; Brain; Cells, Cultured; Cloning, Molecular; Glyburide; Humans; Male; Muscle, Smooth, Vascular; Patch-Clamp Techniques; Pinacidil; Potassium Channels, Inwardly Rectifying; Protein Subunits; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; Vasodilator Agents | 2002 |
The effects of drugs modulating K(+) transport on Rb(+) uptake and distribution in pig hearts following regional ischemia: (87)Rb MRI study.
Topics: Animals; Bumetanide; Glyburide; In Vitro Techniques; Magnetic Resonance Imaging; Myocardial Infarction; Myocardial Ischemia; Myocardial Reperfusion Injury; Pinacidil; Potassium; Potassium Channels; Radiopharmaceuticals; Reference Values; Reperfusion; Rubidium Radioisotopes; Sus scrofa; Tissue Distribution | 2002 |
Vasorelaxing properties of some phenylacridine type potassium channel openers in isolated rabbit thoracic arteries.
Topics: Acridines; Animals; Aorta, Thoracic; Glyburide; Hypoglycemic Agents; In Vitro Techniques; Kinetics; Magnetic Resonance Spectroscopy; Male; Molecular Weight; Muscle, Smooth, Vascular; Phenylephrine; Pinacidil; Potassium Channels; Rabbits; Tetraethylammonium Compounds; Vasoconstrictor Agents; Vasodilator Agents | 2002 |
Activation of adenosine triphosphate-sensitive potassium channels confers protection against rotenone-induced cell death: therapeutic implications for Parkinson's disease.
Topics: Adenosine Triphosphate; Animals; Cell Death; Dose-Response Relationship, Drug; Electron Transport Complex I; Ferrous Compounds; Glyburide; Ischemic Preconditioning; Mitochondria; NADH, NADPH Oxidoreductases; Neurons; Parkinson Disease; Parkinson Disease, Secondary; PC12 Cells; Pinacidil; Potassium Channel Blockers; Potassium Channels; Protein Synthesis Inhibitors; Rats; Rotenone; Uncoupling Agents; Vasodilator Agents; Xanthine; Xanthine Oxidase | 2002 |
Effect of diabetes on pinacidil-induced antinociception in mice.
Topics: Animals; Diabetes Mellitus, Experimental; Dose-Response Relationship, Drug; Glyburide; Injections, Intraventricular; Injections, Spinal; Male; Mice; Mice, Inbred ICR; Narcotic Antagonists; Pain; Pinacidil; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Vasodilator Agents | 2002 |
The role of myocardial KATP-channel blockade in the protective effects of glibenclamide against ischaemia in the rat heart.
Topics: Animals; Coronary Circulation; Diazoxide; Drug Interactions; Glyburide; Male; Myocardial Ischemia; Pinacidil; Potassium Channels; Rats; Rats, Wistar | 2002 |
Developmental expression and functional significance of Kir channel subunits in ureteric bud and nephron epithelia.
Topics: Animals; Animals, Newborn; Cell Division; Cell Line; Down-Regulation; Embryo, Mammalian; Embryonic and Fetal Development; Epithelial Cells; Epithelium; Glyburide; Humans; In Vitro Techniques; Kidney Cortex; Kidney Tubules, Collecting; Nephrons; Pinacidil; Potassium Channels; Potassium Channels, Inwardly Rectifying; Rats; Rats, Wistar; RNA, Messenger; Ureter | 2002 |
Modulation of the trafficking efficiency and functional properties of ATP-sensitive potassium channels through a single amino acid in the sulfonylurea receptor.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Animals; Anti-Arrhythmia Agents; ATP-Binding Cassette Transporters; Blotting, Western; COS Cells; Cricetinae; Diazoxide; Dose-Response Relationship, Drug; Glyburide; Immunoblotting; Luminescent Measurements; Magnesium; Mice; Mutation; Patch-Clamp Techniques; Pinacidil; Potassium; Potassium Channels; Potassium Channels, Inwardly Rectifying; Protein Isoforms; Protein Structure, Tertiary; Protein Transport; Rats; Receptors, Drug; Rubidium; Sulfonylurea Receptors; Time Factors; Transfection; Vasodilator Agents | 2003 |
Isoflurane sensitizes the cardiac sarcolemmal adenosine triphosphate-sensitive potassium channel to pinacidil.
Topics: Androstadienes; Anesthetics, Inhalation; Animals; ATP-Binding Cassette Transporters; Female; Glyburide; Guinea Pigs; Heart; Hypoglycemic Agents; In Vitro Techniques; Isoflurane; KATP Channels; Male; Membrane Potentials; Patch-Clamp Techniques; Phospholipids; Pinacidil; Potassium Channels; Potassium Channels, Inwardly Rectifying; Sarcolemma; Signal Transduction; Vasodilator Agents; Wortmannin | 2003 |
An endothelium-derived factor modulates purinergic neurotransmission to mesenteric arterial smooth muscle of hamster.
Topics: 4-Aminopyridine; Adenosine Triphosphate; Animals; Apamin; Biological Factors; Charybdotoxin; Cricetinae; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Endothelium, Vascular; Enzyme Inhibitors; Epoprostenol; Fatty Acids, Unsaturated; Glyburide; In Vitro Techniques; Indomethacin; Male; Membrane Potentials; Mesenteric Arteries; Mesocricetus; Muscle, Smooth, Vascular; Neuromuscular Junction; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Ouabain; Pinacidil; Purinergic P2 Receptor Antagonists; Receptors, Purinergic P2; Synaptic Transmission; Tetraethylammonium; Time Factors; Triazines; Uridine Triphosphate; Vasodilator Agents | 2003 |
Modulation of slow waves by hyperpolarization with potassium channel openers in antral smooth muscle of the guinea-pig stomach.
Topics: Adrenergic alpha-Agonists; Animals; ATP-Binding Cassette Transporters; Biological Clocks; Decanoic Acids; Electrophysiology; Female; Gastric Mucosa; Glyburide; Guinea Pigs; Hydroxy Acids; In Vitro Techniques; KATP Channels; Male; Membrane Potentials; Microelectrodes; Mitochondria, Muscle; Muscle Contraction; Muscle, Smooth; Nicorandil; Norepinephrine; Pinacidil; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Inwardly Rectifying; Pyloric Antrum; Stomach | 2003 |
ATP-sensitive potassium channels in rat primary afferent neurons: the effect of neuropathic injury and gabapentin.
Topics: Acetates; Amines; Animals; ATP-Binding Cassette Transporters; Basal Ganglia; Cyclohexanecarboxylic Acids; Diazoxide; Excitatory Amino Acid Antagonists; Gabapentin; gamma-Aminobutyric Acid; Ganglia, Spinal; Glyburide; KATP Channels; Male; Neurons, Afferent; Neuroprotective Agents; Pain; Peripheral Nervous System Diseases; Pinacidil; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Inwardly Rectifying; Rats; Rats, Sprague-Dawley | 2003 |
NADH supplementation decreases pinacidil-primed I K ATP in ventricular cardiomyocytes by increasing intracellular ATP.
Topics: Action Potentials; Adenosine Triphosphate; Animals; Dose-Response Relationship, Drug; Glyburide; Guinea Pigs; Heart Ventricles; Myocytes, Cardiac; NAD; Patch-Clamp Techniques; Pinacidil; Potassium Channels; Sarcolemma | 2003 |
ATP-dependent potassium channels involved in the cardiac protection induced by intermittent hypoxia against ischemia/reperfusion injury.
Topics: Animals; Calcium; Decanoic Acids; Glyburide; Heart Ventricles; Hemodynamics; Hydroxy Acids; Hypoxia; In Vitro Techniques; Ischemic Preconditioning, Myocardial; Male; Membrane Proteins; Myocardial Ischemia; Myocytes, Cardiac; Perfusion; Pinacidil; Potassium Channels; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Ventricular Function, Left | 2003 |
Molecular basis and characteristics of KATP channel in human corporal smooth muscle cells.
Topics: ATP-Binding Cassette Transporters; Cells, Cultured; Electric Conductivity; Electrophysiology; Glyburide; Humans; Male; Membrane Potentials; Molsidomine; Muscle, Smooth, Vascular; Penis; Pinacidil; Potassium Channels; Potassium Channels, Inwardly Rectifying; Receptors, Drug; Sulfonylurea Receptors; Vasodilator Agents | 2003 |
Cerebrovascular vasodilation to extraluminal acidosis occurs via combined activation of ATP-sensitive and Ca2+-activated potassium channels.
Topics: Acidosis; Adenosine Triphosphate; Animals; Benzimidazoles; Cerebrovascular Circulation; Enzyme Inhibitors; Glyburide; Hydrogen-Ion Concentration; Hypoglycemic Agents; Male; Middle Cerebral Artery; Muscle, Smooth, Vascular; Nitroarginine; Pinacidil; Potassium; Potassium Channel Blockers; Potassium Channels, Calcium-Activated; Protons; Rats; Rats, Wistar; Tetraethylammonium; Vasodilation; Vasodilator Agents | 2003 |
Nicorandil inhibits the release of TNFalpha from a lymphocyte cell line and peripheral blood lymphocytes.
Topics: B-Lymphocytes; Dose-Response Relationship, Drug; Enzyme Inhibitors; Glyburide; Herpesvirus 4, Human; Humans; Immunoglobulin G; Leukocytes, Mononuclear; Niacinamide; Nicorandil; Nitric Oxide Synthase; Nitroprusside; omega-N-Methylarginine; Oxadiazoles; Pinacidil; Potassium Channels; Quinoxalines; Tetradecanoylphorbol Acetate; Tumor Necrosis Factor-alpha | 2003 |
Pinacidil-induced opening, like glibenclamide-induced closure of cardiac KATP channels, protects cardiac function against ischemia in isolated, working, erythrocyte perfused rat hearts.
Topics: Animals; Glyburide; Heart; In Vitro Techniques; Ion Channel Gating; Male; Myocardial Ischemia; Pinacidil; Potassium Channels; Rats; Rats, Wistar | 2003 |
Unusual effects of a QT-prolonging drug, arsenic trioxide, on cardiac potassium currents.
Topics: Animals; Antineoplastic Agents; Arsenic Trioxide; Arsenicals; CHO Cells; Cricetinae; Cricetulus; Glyburide; Heart; Long QT Syndrome; Myocardium; Oxides; Pinacidil; Potassium Channels; Potassium Channels, Inwardly Rectifying; Potassium Channels, Voltage-Gated | 2004 |
Molecular identity and function in transepithelial transport of K(ATP) channels in alveolar epithelial cells.
Topics: Amiloride; Animals; ATP-Binding Cassette Transporters; Base Sequence; Colforsin; DNA; DNA Primers; Glyburide; Kinetics; Male; Pinacidil; Potassium Channels; Potassium Channels, Inwardly Rectifying; Pulmonary Alveoli; Rats; Rats, Sprague-Dawley; Receptors, Drug; Respiratory Mucosa; Reverse Transcriptase Polymerase Chain Reaction; Sulfonylurea Receptors | 2004 |
Molecular mechanisms of the inhibitory effects of propofol and thiamylal on sarcolemmal adenosine triphosphate-sensitive potassium channels.
Topics: Anesthetics, Intravenous; Animals; ATP-Binding Cassette Transporters; Cells, Cultured; Diazoxide; Electrophysiology; Glyburide; Humans; Molecular Biology; Patch-Clamp Techniques; Pinacidil; Potassium Channels; Potassium Channels, Inwardly Rectifying; Propofol; Rats; Receptors, Drug; Sulfonylurea Receptors; Thiamylal; Vasodilator Agents | 2004 |
Isoflurane and sevoflurane precondition against neutrophil-induced contractile dysfunction in isolated rat hearts.
Topics: Anesthetics, Inhalation; Animals; Female; Glyburide; Heart; In Vitro Techniques; Ischemic Preconditioning, Myocardial; Isoflurane; Male; Membrane Proteins; Methyl Ethers; Myocardial Contraction; Myocardium; Neutrophils; Peroxidase; Pinacidil; Potassium Channel Blockers; Potassium Channels; Rats; Rats, Sprague-Dawley; Sevoflurane; Superoxides; Vasodilator Agents | 2004 |
Caveolae localize protein kinase A signaling to arterial ATP-sensitive potassium channels.
Topics: Adenosine Triphosphate; Adenylyl Cyclases; Animals; Aorta; ATP-Binding Cassette Transporters; Calcitonin Gene-Related Peptide; Caveolae; Caveolin 1; Caveolins; Cell Compartmentation; Cell Fractionation; Cholesterol; Cyclic AMP-Dependent Protein Kinases; Glyburide; Guanosine Diphosphate; Ion Transport; Isoenzymes; KATP Channels; Male; Membrane Lipids; Mesenteric Arteries; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Patch-Clamp Techniques; Peptide Fragments; Pinacidil; Potassium; Potassium Channels, Inwardly Rectifying; Propranolol; Rats; Rats, Wistar; Sphingolipids; Theophylline; Thionucleotides | 2004 |
KATP-channel-induced vasodilation is modulated by the Na,K-pump activity in rabbit coronary small arteries.
Topics: Animals; Arteries; ATP-Binding Cassette Transporters; Cardiotonic Agents; Coronary Vessels; Cromakalim; Female; Glyburide; Hypoglycemic Agents; In Vitro Techniques; KATP Channels; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Ouabain; Patch-Clamp Techniques; Pinacidil; Potassium; Potassium Channels; Potassium Channels, Inwardly Rectifying; Rabbits; Sodium-Potassium-Exchanging ATPase; Vasodilation; Vasodilator Agents | 2004 |
Pacemaker potentials generated by interstitial cells of Cajal in the murine intestine.
Topics: Animals; Anti-Arrhythmia Agents; Biological Clocks; Caffeine; Calcium Channel Blockers; Central Nervous System Stimulants; Electrophysiology; Glyburide; In Vitro Techniques; Intestine, Small; Membrane Potentials; Mibefradil; Mice; Mice, Inbred BALB C; Myocytes, Smooth Muscle; Nifedipine; Pinacidil; Vasodilator Agents | 2005 |
Alteration of binding sites for [3H]P1075 and [3H]glibenclamide in renovascular hypertensive rat aorta.
Topics: Animals; Antihypertensive Agents; Aorta; Binding Sites; Glyburide; Guanidines; Hypertension, Renovascular; In Vitro Techniques; Kinetics; Male; Pinacidil; Potassium Channels; Pyridines; Rats; Rats, Wistar; Vasodilator Agents | 2005 |
Role of KATP channels in the regulation of rat dura and pia artery diameter.
Topics: Animals; Arteries; Cromakalim; Dura Mater; Glyburide; Male; Pia Mater; Pinacidil; Potassium Channels; Rats; Rats, Sprague-Dawley; Vasodilation; Vasodilator Agents | 2005 |
[Iptakalim enhances astrocytic glutamate uptake activity].
Topics: Animals; Animals, Newborn; Astrocytes; Cells, Cultured; Cerebral Cortex; Glutamates; Glyburide; Neuroprotective Agents; Oxidopamine; Pinacidil; Propylamines; Rats; Rats, Sprague-Dawley; Vasodilator Agents | 2004 |
Effects of pinacidil on proliferation of cultured rabbit airway smooth muscle cells induced by endothelin-1.
Topics: Animals; Cell Cycle; Cell Proliferation; Cells, Cultured; Endothelin-1; Glyburide; Pinacidil; Potassium Channels; Rabbits; Thymidine; Trachea | 2005 |
2-(1-Hexyn-1-yl)adenosine-induced intraocular hypertension is mediated via K+ channel opening through adenosine A2A receptor in rabbits.
Topics: Adenosine; Adenosine A2 Receptor Agonists; Adenosine A2 Receptor Antagonists; Alkynes; Animals; Antihypertensive Agents; Caffeine; Decanoic Acids; Glyburide; Hydroxy Acids; Hypotonic Solutions; Intraocular Pressure; Male; Ocular Hypertension; Phenethylamines; Pinacidil; Potassium Channel Blockers; Potassium Channels; Rabbits; Receptor, Adenosine A2A; Sodium Chloride; Time Factors; Xanthines | 2005 |
KATP channel conductance of descending vasa recta pericytes.
Topics: Angiotensin II; Animals; ATP-Binding Cassette Transporters; Electric Capacitance; Endothelin-1; Glyburide; Juxtaglomerular Apparatus; KATP Channels; Membrane Potentials; Pericytes; Pinacidil; Potassium Channels, Inwardly Rectifying; Rats; Rats, Sprague-Dawley; Vasopressins | 2005 |
Glibenclamide reveals role for endothelin in hypoxia-induced vasoconstriction in rat intrapulmonary arteries.
Topics: Animals; Anti-Arrhythmia Agents; Carboxylic Acids; Dose-Response Relationship, Drug; Endothelin Receptor Antagonists; Endothelins; Endothelium, Vascular; Enzyme Inhibitors; Glyburide; Hypoxia; In Vitro Techniques; Indans; Male; Nitric Oxide Synthase; Nitroarginine; Oligopeptides; Oxyhemoglobins; Peptides, Cyclic; Phenylephrine; Pinacidil; Piperidines; Pulmonary Artery; Rats; Rats, Wistar; Receptors, Endothelin; Vasoconstriction; Vasoconstrictor Agents; Vasodilator Agents | 2005 |
Effects of calcium channel blocker, mibefradil, and potassium channel opener, pinacidil, on the contractile response of mid-pregnant goat myometrium.
Topics: Adenosine Triphosphate; Animals; Calcium Channel Blockers; Dose-Response Relationship, Drug; Female; Glyburide; Goats; Humans; Mibefradil; Myometrium; Oxytocin; Pinacidil; Potassium; Potassium Channels; Pregnancy; Pregnancy, Animal; Uterine Contraction; Uterus | 2005 |
Characterization of K(ATP)-channels in rat basilar and middle cerebral arteries: studies of vasomotor responses and mRNA expression.
Topics: Animals; ATP-Binding Cassette Transporters; Basilar Artery; Binding Sites; Chlorocebus aethiops; COS Cells; Endothelium, Vascular; Glyburide; Guanidines; Ion Channel Gating; KATP Channels; Male; Middle Cerebral Artery; Multidrug Resistance-Associated Proteins; Organic Chemicals; Pinacidil; Potassium Channels; Potassium Channels, Inwardly Rectifying; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, Drug; RNA, Messenger; Sulfonylurea Receptors; Transfection; Vasodilation; Vasodilator Agents | 2005 |
The regulation of rotenone-induced inflammatory factor production by ATP-sensitive potassium channel expressed in BV-2 cells.
Topics: Animals; ATP-Binding Cassette Transporters; Blotting, Western; Cell Line; Decanoic Acids; Drug Interactions; Gene Expression Regulation; Glyburide; Hydroxy Acids; Mice; Microglia; Nitric Oxide Synthase Type II; Pinacidil; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Inwardly Rectifying; Propylamines; Receptors, Drug; Rotenone; Sulfonylurea Receptors; Tumor Necrosis Factor-alpha | 2006 |
Effects of pine needle extract on pacemaker currents in interstitial cells of Cajal from the murine small intestine.
Topics: Adenosine Triphosphate; Animals; Cells, Cultured; Dose-Response Relationship, Drug; Electrophysiology; Glyburide; Intestine, Small; Membrane Potentials; Mice; Mice, Inbred BALB C; Naproxen; Pinacidil; Pinus; Plant Extracts; Potassium Channels; Prostaglandins | 2005 |
Adenosine- and hypoxia-induced dilation of human coronary resistance arteries: evidence against the involvement of K(ATP) channels.
Topics: Adenosine; Aged; Cell Hypoxia; Coronary Vessels; Dilatation, Pathologic; Drug Interactions; Female; Glyburide; Humans; In Vitro Techniques; Male; Middle Aged; Pinacidil; Potassium Channels; Vasodilator Agents | 2006 |
KATP channels in mouse spermatogenic cells and sperm, and their role in capacitation.
Topics: Adenosine Triphosphate; Animals; ATP-Binding Cassette Transporters; Barium; Diazoxide; Dose-Response Relationship, Drug; Glyburide; KATP Channels; Male; Membrane Potentials; Mice; Microscopy, Confocal; Multidrug Resistance-Associated Proteins; Pinacidil; Potassium Channels, Inwardly Rectifying; Receptors, Drug; RNA, Messenger; Sperm Capacitation; Spermatogenesis; Spermatozoa; Sulfonylurea Receptors; Time Factors; Tolbutamide | 2006 |
The nitric oxide-cyclic GMP-protein kinase G-K+ channel pathway participates in the antiallodynic effect of spinal gabapentin.
Topics: Amines; Analgesics; Animals; Apamin; Carbazoles; Charybdotoxin; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Cyclohexanecarboxylic Acids; Diazoxide; Dose-Response Relationship, Drug; Enzyme Inhibitors; Female; Gabapentin; gamma-Aminobutyric Acid; Glyburide; Indazoles; Indoles; Injections, Spinal; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Okadaic Acid; Oxadiazoles; Pain; Pinacidil; Potassium Channel Blockers; Potassium Channels; Protein Kinase Inhibitors; Quinoxalines; Rats; Rats, Wistar; Signal Transduction; Spinal Nerves; Stereoisomerism; Time Factors; Vasodilator Agents | 2006 |
Investigation of the relaxant effects of pinacidil and cromakalim on the sheep sphincter of Oddi.
Topics: Animals; Cromakalim; Glyburide; In Vitro Techniques; Male; Muscle Relaxation; Parasympatholytics; Pinacidil; Potassium Channels; Sheep; Sphincter of Oddi | 2006 |
Hypotonic stress enhances slope conductivity of ATP-sensitive K+ channels activated pharmacologically.
Topics: Adenosine Triphosphate; Animals; Anti-Arrhythmia Agents; Chromans; Female; Glyburide; Guinea Pigs; Hypotonic Solutions; Male; Myocytes, Cardiac; Pinacidil; Potassium Channels; Pyrrolidines | 2007 |
Role of ATP-dependent potassium channels in pulmonary vascular tone of fetal lambs with congenital diaphragmatic hernia.
Topics: Adenosine Triphosphate; Animals; Female; Glyburide; Hernia, Diaphragmatic; Hernias, Diaphragmatic, Congenital; Hypertension, Pulmonary; Lung; Muscle, Smooth, Vascular; Phenylephrine; Pinacidil; Potassium Channels; Pregnancy; Pulmonary Circulation; Sheep, Domestic; Vascular Resistance; Vasoconstrictor Agents; Vasodilator Agents | 2006 |
Effects of anthocyanidin derivative (HK-008) on relaxation in rat perfused mesenterial bed.
Topics: Acetylcholine; Animals; Anthocyanins; Antioxidants; Aorta, Thoracic; Blood Glucose; Diabetes Mellitus, Type 2; Glyburide; Humans; In Vitro Techniques; Male; Mesenteric Arteries; Oxidative Stress; Perfusion; Pinacidil; Rats; Rats, Wistar; Vasodilation; Vasodilator Agents | 2006 |
A key role for the subunit SUR2B in the preferential activation of vascular KATP channels by isoflurane.
Topics: Anesthetics, Inhalation; Animals; Aorta, Thoracic; ATP-Binding Cassette Transporters; Cell Line; Cells, Cultured; Coronary Circulation; Dose-Response Relationship, Drug; G Protein-Coupled Inwardly-Rectifying Potassium Channels; Glyburide; Humans; In Vitro Techniques; Isoflurane; Membrane Potentials; Mice; Mice, Inbred C57BL; Myocytes, Cardiac; Patch-Clamp Techniques; Pinacidil; Potassium Channels; Potassium Channels, Inwardly Rectifying; Receptors, Drug; Sulfonylurea Receptors; Theophylline; Transfection; Vasodilation | 2006 |
Actions of ZD0947, a novel ATP-sensitive K+ channel opener, on membrane currents in human detrusor myocytes.
Topics: ATP-Binding Cassette Transporters; Carbachol; Diazoxide; Dihydropyridines; Dose-Response Relationship, Drug; G Protein-Coupled Inwardly-Rectifying Potassium Channels; Gliclazide; Glyburide; Humans; Immunochemistry; In Vitro Techniques; Membrane Potentials; Muscle Relaxation; Myocytes, Smooth Muscle; Patch-Clamp Techniques; Pinacidil; Potassium Channels; Potassium Channels, Inwardly Rectifying; Receptors, Drug; Sulfonylurea Receptors; Urinary Bladder | 2006 |
[Effects of ATP-regulated potassium channels modulators, N-(2-pyridyl)-N'-(4-toluol) sulfonylcarbamides, on electromechanical activity in guinea pig myocardium].
Topics: Action Potentials; Adenosine Triphosphate; Aminopyridines; Animals; Glyburide; Guinea Pigs; Myocardial Contraction; Papillary Muscles; Pinacidil; Potassium Channels; Time Factors; Vasodilator Agents | 2006 |
Identification of two types of ATP-sensitive K+ channels in rat ventricular myocytes.
Topics: Animals; Blotting, Western; Calcium; Diazoxide; Dinitrophenols; Dose-Response Relationship, Drug; Fluorescent Antibody Technique, Direct; Gene Expression; Glyburide; Heart Ventricles; KATP Channels; Male; Membrane Potentials; Myocytes, Cardiac; Patch-Clamp Techniques; Pinacidil; Potassium Channels, Inwardly Rectifying; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger | 2007 |
ATP-sensitive potassium channels expressed by human monocytes play a role in stasis-induced thrombogenesis via tissue factor pathway.
Topics: Adenosine Triphosphate; Adult; Blood Coagulation; Calcium; Gene Expression; Glyburide; Humans; Leukocytes, Mononuclear; Lipopolysaccharides; Male; Membrane Potentials; Monocytes; Phosphatidylserines; Pinacidil; Potassium Channels, Inwardly Rectifying; RNA, Messenger; Thromboplastin; Thrombosis | 2007 |
Effect of KATP channel openers on myogenic and neurogenic responses in goat urinary bladder.
Topics: Acetylcholine; Animals; Atropine; Cholinergic Agents; Cromakalim; Dose-Response Relationship, Drug; Electric Stimulation; Female; Glyburide; Goats; In Vitro Techniques; Male; Muscarinic Antagonists; Muscle Contraction; Muscle, Smooth; Pinacidil; Potassium Channel Blockers; Potassium Channels; Urinary Bladder | 2007 |
Inhibition of KATP channels in the rat tail artery by neurally released noradrenaline acting on postjunctional alpha2-adrenoceptors.
Topics: Adamantane; Adenosine Triphosphate; Animals; Arteries; Calcitonin Gene-Related Peptide; Cromakalim; Dose-Response Relationship, Drug; Electric Impedance; Excitatory Postsynaptic Potentials; Female; Glyburide; In Vitro Techniques; Ion Channel Gating; Morpholines; Muscle, Smooth, Vascular; Norepinephrine; Pinacidil; Potassium Channel Blockers; Potassium Channels; Rats; Rats, Wistar; Receptors, Adrenergic, alpha-2; Sympathetic Nervous System; Tail; Time Factors | 2007 |
Arginine vasopressin inhibits Kir6.1/SUR2B channel and constricts the mesenteric artery via V1a receptor and protein kinase C.
Topics: Algorithms; Arginine Vasopressin; Cell Line; Enzyme Inhibitors; Glyburide; Humans; KATP Channels; Mesenteric Arteries; Myocytes, Smooth Muscle; Naphthalenes; Pinacidil; Potassium Channel Blockers; Potassium Channels, Inwardly Rectifying; Protein Kinase C; Receptors, Vasopressin; Signal Transduction; Vasoconstrictor Agents; Vasodilator Agents | 2007 |
Effects of extracellular HCO3(-) on fatigue, pHi, and K+ efflux in rat skeletal muscles.
Topics: Animals; Bicarbonates; Dose-Response Relationship, Drug; Female; Glyburide; Hydrogen-Ion Concentration; Isometric Contraction; Male; Muscle Contraction; Muscle Fatigue; Muscle, Skeletal; Physical Conditioning, Animal; Pinacidil; Potassium; Potassium Channel Blockers; Potassium Channels; Rats; Rats, Wistar | 2007 |
Effect of K+ATP channel and adenosine receptor blockade during rest and exercise in congestive heart failure.
Topics: Adenosine Triphosphate; Animals; Anti-Arrhythmia Agents; Blood Flow Velocity; Cardiac Pacing, Artificial; Coronary Circulation; Disease Models, Animal; Dogs; Exercise Test; Glyburide; Heart; Heart Failure; Oxygen Consumption; Physical Exertion; Pinacidil; Potassium Channel Blockers; Potassium Channels; Purinergic P1 Receptor Antagonists; Rest; Theophylline; Vasodilator Agents | 2007 |
Vasodilator effect of nicorandil on retinal blood vessels in rats.
Topics: Analysis of Variance; Animals; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Glyburide; Indomethacin; Male; Nicorandil; Nitric Oxide; Nitric Oxide Donors; Nitroprusside; Pinacidil; Potassium Channel Blockers; Rats; Rats, Wistar; Retinal Vessels; Vasodilation; Vasodilator Agents | 2007 |
The effect of potassium channel opener pinacidil on the non-pregnant rat uterus.
Topics: Animals; Electric Stimulation; Female; Glyburide; In Vitro Techniques; Muscle Contraction; Oxytocics; Oxytocin; Pinacidil; Potassium Channel Blockers; Potassium Channels; Potassium Chloride; Rats; Rats, Wistar; Uterus; Vasodilator Agents | 2007 |
Effect of pravastatin on sympathetic reinnervation in postinfarcted rats.
Topics: Animals; Blotting, Western; Cardiac Pacing, Artificial; Coronary Vessels; Disease Models, Animal; GAP-43 Protein; Glyburide; Heart; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Immunohistochemistry; KATP Channels; Ligation; Male; Myocardial Infarction; Myocardium; Neurofilament Proteins; Nicorandil; Norepinephrine; Pinacidil; Polymerase Chain Reaction; Potassium Channel Blockers; Pravastatin; Rats; Rats, Wistar; RNA, Messenger; Sympathetic Nervous System; Tachycardia, Ventricular; Time Factors; Tyrosine 3-Monooxygenase; Ventricular Fibrillation; Ventricular Remodeling | 2007 |
Effects of prostaglandin E1 on vascular ATP-sensitive potassium channels.
Topics: Algorithms; Alprostadil; Analysis of Variance; Animals; Aorta, Thoracic; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Dose-Response Relationship, Drug; Glyburide; In Vitro Techniques; KATP Channels; Male; Patch-Clamp Techniques; Phenylephrine; Pinacidil; Protein Kinase Inhibitors; Rats; Rats, Wistar; Thionucleotides; Vasoconstriction; Vasodilation; Vasodilator Agents | 2007 |
Vasodilator effects of adenosine on retinal arterioles in streptozotocin-induced diabetic rats.
Topics: Acetylcholine; Adenosine; Animals; Arterioles; Blood Pressure; Diabetes Mellitus, Experimental; Enzyme Inhibitors; Glyburide; Heart Rate; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Pinacidil; Potassium Channel Blockers; Rats; Rats, Wistar; Retinal Vessels; Streptozocin; Vasodilation; Vasodilator Agents | 2008 |
Diclofenac exerts local anesthetic-like actions on rat masseter muscle afferent fibers.
Topics: Analysis of Variance; Anesthetics; Animals; Diclofenac; Dose-Response Relationship, Drug; Drug Interactions; Female; Glyburide; Hypoglycemic Agents; Lidocaine; Male; Masseter Muscle; Muscle Fibers, Skeletal; Physical Stimulation; Pinacidil; Potassium Channel Blockers; Potassium Chloride; Rats; Rats, Sprague-Dawley; Sensory Thresholds | 2008 |
The role of potassium ion channels in cough and other reflexes of the airways.
Topics: Acetylcholine; Aerosols; Airway Resistance; Animals; Benzimidazoles; Citric Acid; Cough; Glyburide; Guinea Pigs; Histamine; KATP Channels; Muscle, Smooth; Pinacidil; Plethysmography; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Calcium-Activated; Reflex; Respiratory Mechanics; Respiratory Muscles; Respiratory Physiological Phenomena; Vasodilator Agents | 2007 |
Effect of ATP-sensitive potassium channel agonists on ventricular remodeling in healed rat infarcts.
Topics: Animals; Glyburide; Hemodynamics; Hypertrophy, Left Ventricular; Immunohistochemistry; KATP Channels; Male; Muscle Cells; Myocardial Infarction; Nicorandil; Pinacidil; Rats; Rats, Wistar; Risk Factors; Time Factors; Ventricular Remodeling | 2008 |
KATP channel openers have opposite effects on mitochondrial respiration under different energetic conditions.
Topics: Animals; Decanoic Acids; Diazoxide; Electron Transport Complex I; Electron Transport Complex II; Glyburide; Guinea Pigs; Hydroxy Acids; In Vitro Techniques; Mitochondria, Heart; Mitochondrial Proton-Translocating ATPases; Oxygen Consumption; Pinacidil; Potassium Channel Blockers; Potassium Channels | 2008 |
Decreased expression of aortic KIR6.1 and SUR2B in hypertension does not correlate with changes in the functional role of K(ATP) channels.
Topics: Animals; Antihypertensive Agents; Aorta, Thoracic; ATP-Binding Cassette Transporters; Blotting, Western; Cromakalim; Glyburide; Hypertension; Hypoglycemic Agents; Immunohistochemistry; KATP Channels; Male; Muscle, Smooth, Vascular; Patch-Clamp Techniques; Pinacidil; Potassium Channels, Inwardly Rectifying; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Receptors, Drug; Sulfonylurea Receptors | 2008 |
Upregulation of ATP-sensitive potassium channels for estrogen-mediated cell proliferation in human uterine leiomyoma cells.
Topics: Adult; Cell Growth Processes; Estradiol; Estrogen Receptor alpha; Estrogen Receptor beta; Female; Formazans; Glyburide; Humans; Immunoblotting; KATP Channels; Leiomyoma; Middle Aged; Patch-Clamp Techniques; Pinacidil; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tetrazolium Salts; Up-Regulation; Uterine Neoplasms | 2008 |
Downregulation of Kir6.1/SUR2B channels in the obese rat aorta.
Topics: Animals; Aorta; ATP-Binding Cassette Transporters; Blood Pressure; Blotting, Western; Down-Regulation; Glyburide; KATP Channels; Male; Muscle, Smooth, Vascular; Obesity; Patch-Clamp Techniques; Pinacidil; Potassium Channels, Inwardly Rectifying; Random Allocation; Rats; Rats, Sprague-Dawley; Receptors, Drug; Reverse Transcriptase Polymerase Chain Reaction; Sulfonylurea Receptors; Vasodilator Agents | 2009 |
Molecular and functional characterization of a new potassium conductance in mouse ventricular fibroblasts.
Topics: Actins; Animals; ATP-Binding Cassette Transporters; Cell Proliferation; Cells, Cultured; Fibroblasts; Gene Expression Regulation; Glyburide; Heart Ventricles; Interleukin-6; Ion Channel Gating; KATP Channels; Lysophospholipids; Mice; Pinacidil; Potassium Channels, Inwardly Rectifying; Protein Subunits; Receptors, Drug; RNA, Messenger; Sphingosine; Sulfonylurea Receptors | 2009 |
Blockade of K(ATP) channels reduces endothelial hyperpolarization and leukocyte recruitment upon reperfusion after hypoxia.
Topics: Animals; Cats; Cell Membrane; Endothelium, Vascular; Gelatin; Glyburide; Humans; Hypoxia; KATP Channels; Leukocytes; Neutrophils; Pinacidil; Reperfusion Injury; Umbilical Veins | 2009 |
Effect of ATP-sensitive potassium channel agonists on sympathetic hyperinnervation in postinfarcted rat hearts.
Topics: Animals; Arrhythmias, Cardiac; Echocardiography; Endothelin-1; Glyburide; Heart; Hypoglycemic Agents; Male; Myocardial Infarction; Nerve Growth Factor; Nicorandil; Norepinephrine; Pinacidil; Potassium Channels; Rats; Rats, Wistar; RNA, Messenger; Sympathetic Nervous System; Vasodilator Agents | 2009 |
Endogenous and exogenous hydrogen sulfide promotes resolution of colitis in rats.
Topics: Analysis of Variance; Animals; Biomarkers; Biopsy, Needle; Colitis; Cyclooxygenase 1; Cyclooxygenase 2; Disease Models, Animal; Glyburide; Hydrogen Sulfide; Immunohistochemistry; Male; Pinacidil; Probability; Random Allocation; Rats; Rats, Wistar; Reverse Transcriptase Polymerase Chain Reaction; Sensitivity and Specificity; Statistics, Nonparametric; Survival Rate; Treatment Outcome; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha | 2009 |
The influence of animal species on the relationship between ATP-sensitive potassium ion channels and defense reflexes of the airways.
Topics: Animals; Antitussive Agents; Cats; Citric Acid; Cough; Female; Glyburide; Guinea Pigs; KATP Channels; Male; Muscle Contraction; Muscle, Smooth; Physical Stimulation; Pinacidil; Potassium Channel Blockers; Potassium Channels; Propylene Glycols; Reflex; Trachea | 2009 |
Differential K(ATP) channel pharmacology in intact mouse heart.
Topics: Action Potentials; Animals; ATP-Binding Cassette Transporters; Diazoxide; Glyburide; Heart; In Vitro Techniques; KATP Channels; Mice; Mice, Knockout; Microscopy; Myocardium; Pinacidil; Potassium Channels, Inwardly Rectifying; Receptors, Drug; Sulfonylurea Receptors; Vasodilator Agents | 2010 |
Hydrogen sulfide attenuates epithelial-mesenchymal transition of human alveolar epithelial cells.
Topics: Benzodioxoles; Cadherins; Cell Line, Tumor; Cell Transdifferentiation; Cystathionine gamma-Lyase; Drug Interactions; Epithelial Cells; Glyburide; Humans; Hydrogen Sulfide; Imidazoles; Phosphorylation; Pinacidil; Pulmonary Alveoli; Pulmonary Fibrosis; Pyridines; Smad2 Protein; Smad3 Protein; Transforming Growth Factor beta1; Vimentin | 2010 |
Hydrogen sulfide opens the KATP channel on rat atrial and ventricular myocytes.
Topics: Action Potentials; Animals; Glyburide; Heart Atria; Heart Ventricles; Hydrogen Sulfide; Hypoglycemic Agents; KATP Channels; Male; Membrane Transport Modulators; Myocytes, Cardiac; Patch-Clamp Techniques; Pinacidil; Rats; Rats, Wistar | 2010 |
Inhibition of oxygen consumption in skeletal muscle-derived mitochondria by pinacidil, diazoxide, and glibenclamide, but not by 5-hydroxydecanoate.
Topics: Animals; Chickens; Decanoic Acids; Diazoxide; Glyburide; Hydroxy Acids; In Vitro Techniques; Mitochondria, Muscle; Muscle, Skeletal; Oxygen Consumption; Pinacidil; Potassium Channel Blockers; Potassium Channels | 2010 |
Effects of nicorandil on the cAMP-dependent Cl- current in guinea-pig ventricular cells.
Topics: Adrenergic beta-Antagonists; Animals; Antihypertensive Agents; Chloride Channels; Cyclic AMP; Glyburide; Guinea Pigs; Heart Ventricles; Hypoglycemic Agents; Isoproterenol; Nicorandil; Nitric Oxide Donors; Patch-Clamp Techniques; Pinacidil; S-Nitroso-N-Acetylpenicillamine | 2010 |
Effects of imatinib mesylate in interstitial cells of Cajal from murine small intestine.
Topics: Animals; Benzamides; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Dose-Response Relationship, Drug; Female; Gastrointestinal Agents; Glyburide; Imatinib Mesylate; Interstitial Cells of Cajal; Intestine, Small; KATP Channels; Male; Membrane Potentials; Mice; Mice, Inbred BALB C; Patch-Clamp Techniques; Pinacidil; Piperazines; Potassium Channels; Prostaglandins; Protein Kinase C; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-kit; Pyrimidines; Receptors, Prostaglandin E | 2010 |
Effects of K openers on the QT prolongation induced by HERG-blocking drugs in guinea-pigs.
Topics: Animals; Benzothiadiazines; Cromakalim; Decanoic Acids; Ether-A-Go-Go Potassium Channels; Glyburide; Guinea Pigs; Heart; Humans; Hydroxy Acids; Intracellular Membranes; KATP Channels; Long QT Syndrome; Male; Membrane Transport Modulators; Mitochondrial Membranes; Picolines; Pinacidil; Potassium Channel Blockers; Pyrans; Sarcolemma; Tolbutamide | 2010 |
Sarcolemmal cardiac K(ATP) channels as a target for the cardioprotective effects of the fluorine-containing pinacidil analogue, flocalin.
Topics: Animals; Cardiotonic Agents; Cells, Cultured; Fluorine; Glyburide; Guinea Pigs; Heart; HEK293 Cells; Humans; KATP Channels; Male; Membrane Potentials; Membrane Transport Modulators; Myocardium; Myocytes, Cardiac; Patch-Clamp Techniques; Pinacidil; Rats; Reperfusion Injury; Sarcolemma | 2011 |
Cirrhosis decreases vasoconstrictor response to electrical field stimulation in rat mesenteric artery: role of calcitonin gene-related peptide.
Topics: Animals; ATP-Binding Cassette Transporters; Calcitonin Gene-Related Peptide; Calcitonin Gene-Related Peptide Receptor Antagonists; Calcitonin Receptor-Like Protein; Carbon Tetrachloride; Cyclic GMP; Electric Stimulation; Glyburide; KATP Channels; Liver Cirrhosis; Male; Mesenteric Arteries; Muscle Cells; Oxadiazoles; Peptide Fragments; Pinacidil; Potassium Channels, Inwardly Rectifying; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptor Activity-Modifying Protein 1; Receptors, Calcitonin Gene-Related Peptide; Receptors, Drug; Sulfonylurea Receptors; Vasoconstriction; Vasodilation | 2011 |
[Regulatory effects of nucleotides on ATP-sensitive potassium channel opener pinacidil-induced vascular relaxation].
Topics: Animals; Aorta; Glyburide; In Vitro Techniques; KATP Channels; Male; Muscle, Smooth, Vascular; Nucleotides; Pinacidil; Rats; Rats, Wistar; Vasodilator Agents | 2005 |
Effects of potassium channel modulators on myogenic spontaneous phasic contractile activity in human detrusor from neurogenic patients.
Topics: Action Potentials; Adult; Aged; Apamin; Benzimidazoles; Case-Control Studies; Glyburide; Humans; In Vitro Techniques; Membrane Transport Modulators; Middle Aged; Muscle Contraction; Muscle, Smooth; Peptides; Pinacidil; Potassium Channel Blockers; Potassium Channels; Urinary Bladder, Overactive; Urothelium | 2011 |
Hydrogen sulfide dilates cerebral arterioles by activating smooth muscle cell plasma membrane KATP channels.
Topics: Animals; Arterioles; ATP-Binding Cassette Transporters; Cell Membrane; Cerebral Arteries; Female; Glyburide; Hydrogen Sulfide; KATP Channels; Male; Mice; Mice, Knockout; Models, Animal; Muscle, Smooth, Vascular; Patch-Clamp Techniques; Pinacidil; Potassium Channels, Inwardly Rectifying; Receptors, Drug; Sulfonylurea Receptors; Swine; Vasodilation; Vasodilator Agents | 2011 |
Activation of ATP-sensitive potassium channels antagonize nociceptive behavior and hyperexcitability of DRG neurons from rats.
Topics: Animals; Behavior, Animal; Bradykinin; Diazoxide; Ganglia, Spinal; Glyburide; Ion Channel Gating; KATP Channels; Male; Membrane Potentials; Nociceptors; Pain; Physical Stimulation; Pinacidil; Rats; Rats, Sprague-Dawley; Temperature | 2011 |
Inhibitory effect of caffeine on pacemaker activity in the oviduct is mediated by cAMP-regulated conductances.
Topics: 1-Methyl-3-isobutylxanthine; Adenylyl Cyclases; Animals; ATP-Binding Cassette Transporters; Biological Clocks; Caffeine; Colforsin; Cyclic AMP; Drug Interactions; Female; Glyburide; KATP Channels; Membrane Potentials; Mice; Mice, Inbred BALB C; Muscle Contraction; Muscle, Smooth; Oviducts; Phosphodiesterase Inhibitors; Pinacidil; Potassium Channels, Inwardly Rectifying; Receptors, Drug; Sulfonylurea Receptors | 2011 |
Hypoxia and reoxygenation modulate the arrhythmogenic activity of the pulmonary vein and atrium.
Topics: Action Potentials; Animals; Arrhythmias, Cardiac; Atrial Fibrillation; Blotting, Western; Chloramphenicol; Glyburide; Glycine; Heart Atria; HSP70 Heat-Shock Proteins; Hypoglycemic Agents; Hypoxia; In Vitro Techniques; Male; Oxygen; Pinacidil; Protein Synthesis Inhibitors; Pulmonary Veins; Rabbits; Reactive Oxygen Species; Tiopronin; Vasodilator Agents | 2012 |
[Ontogeny of sulphonylurea-binding regulatory subunits of K(ATP) channels in the pregnant rat myometrium].
Topics: Animals; ATP-Binding Cassette Transporters; Blotting, Western; Diazoxide; Female; Gene Expression Regulation; Glyburide; KATP Channels; Myometrium; Oxytocin; Pinacidil; Potassium Channel Blockers; Potassium Channels, Inwardly Rectifying; Pregnancy; Protein Isoforms; Protein Subunits; Rats; Rats, Sprague-Dawley; Receptors, Drug; RNA, Messenger; Sulfonylurea Compounds; Sulfonylurea Receptors; Tocolytic Agents; Uterine Contraction | 2011 |
K+ channels regulate ENaC expression via changes in promoter activity and control fluid clearance in alveolar epithelial cells.
Topics: Benzodiazepines; Biological Transport; Blotting, Western; Cell Line, Tumor; Epithelial Cells; Epithelial Sodium Channels; Extracellular Signal-Regulated MAP Kinases; Gene Expression Regulation, Neoplastic; Glyburide; Humans; KATP Channels; KCNQ1 Potassium Channel; Membrane Transport Modulators; Pinacidil; Potassium Channel Blockers; Promoter Regions, Genetic; Pulmonary Alveoli; Quaternary Ammonium Compounds; Reverse Transcriptase Polymerase Chain Reaction; RNA Interference; Sodium | 2012 |
Rotenone induces KATP channel opening in PC12 cells in association with the expression of tyrosine hydroxylase.
Topics: Animals; Dopamine; Dopaminergic Neurons; Dose-Response Relationship, Drug; Energy Metabolism; Glyburide; KATP Channels; Membrane Potential, Mitochondrial; Patch-Clamp Techniques; PC12 Cells; Pinacidil; Rats; Reactive Oxygen Species; Rotenone; Tyrosine 3-Monooxygenase | 2012 |
CYP-epoxygenases contribute to A2A receptor-mediated aortic relaxation via sarcolemmal KATP channels.
Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Alcohol Oxidoreductases; Animals; Cromakalim; Decanoic Acids; Female; Glyburide; Hydroxy Acids; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Oxidoreductases; Phenethylamines; Pinacidil; Receptor, Adenosine A2A; Sarcolemma | 2012 |
Up-regulated ATP-sensitive potassium channels play a role in increased inflammation and plaque vulnerability in macrophages.
Topics: Animals; Atherosclerosis; Cell Line; Glyburide; Inflammation; KATP Channels; Macrophages; Mice; Pinacidil; Tumor Suppressor Protein p53; Up-Regulation | 2013 |
Fibroblast KATP currents modulate myocyte electrophysiology in infarcted hearts.
Topics: Action Potentials; Animals; ATP-Binding Cassette Transporters; Fibroblasts; Glyburide; Heart Ventricles; KATP Channels; Male; Myocardial Infarction; Myocytes, Cardiac; Pinacidil; Potassium Channel Blockers; Potassium Channels, Inwardly Rectifying; Rats; Rats, Wistar; Receptors, Drug; RNA, Messenger; RNA, Small Interfering; Sulfonylurea Receptors; Transcription, Genetic; Voltage-Sensitive Dye Imaging | 2013 |
Potassium channel openers increase aortic elastic fiber formation and reverse the genetically determined elastin deficit in the BN rat.
Topics: Animals; Antihypertensive Agents; Aorta; Blood Pressure; Diazoxide; Elastic Tissue; Elastin; Glyburide; Male; Minoxidil; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Pinacidil; Potassium Channels; Rats; Rats, Inbred BN; Vasodilator Agents | 2013 |
The effect of resveratrol on contractility of non-pregnant rat uterus: the contribution of K(+) channels.
Topics: 4-Aminopyridine; Animals; Benzimidazoles; Female; Glyburide; Isometric Contraction; Muscle, Smooth; Oxytocin; Peptides; Pinacidil; Potassium Channel Blockers; Potassium Channels; Rats; Rats, Wistar; Resveratrol; Stilbenes; Tetraethylammonium; Uterus | 2013 |
Role of ATP-sensitive potassium channels in modulating nociception in rat model of bone cancer pain.
Topics: Animals; Bone Neoplasms; Cell Line, Tumor; Disease Models, Animal; Female; Glyburide; Hyperalgesia; Membrane Transport Modulators; Neoplasms, Experimental; Nociception; Pain; Pain Threshold; Pinacidil; Potassium Channel Blockers; Potassium Channels, Inwardly Rectifying; Rats; Rats, Wistar; RNA, Messenger; RNA, Small Interfering; Spinal Cord; Touch | 2014 |
Glibenclamide decreases ATP-induced intracellular calcium transient elevation via inhibiting reactive oxygen species and mitochondrial activity in macrophages.
Topics: Adenosine Triphosphate; Analysis of Variance; Animals; Calcium; Cell Line; Fluoresceins; Fluorescence; Fura-2; Glyburide; Macrophages; Membrane Potential, Mitochondrial; Mice; Mitochondria; Pinacidil; Potassium Channels; Reactive Oxygen Species; Rhodamine 123; Rotenone | 2014 |
H2S relaxes isolated human airway smooth muscle cells via the sarcolemmal K(ATP) channel.
Topics: Bronchi; Bronchodilator Agents; Cells, Cultured; Cystathionine gamma-Lyase; Glyburide; Humans; Hydrogen Sulfide; KATP Channels; Morpholines; Muscle Relaxation; Myocytes, Smooth Muscle; Organothiophosphorus Compounds; Pinacidil; Sarcolemma; Sulfides | 2014 |
ATP-sensitive potassium channels modulate in vitro tocolytic effects of β₂-adrenergic receptor agonists on uterine muscle rings in rats in early but not in late pregnancy.
Topics: Adrenergic beta-2 Receptor Agonists; Albuterol; Animals; Drug Synergism; Female; Glyburide; In Vitro Techniques; KATP Channels; Myometrium; Pinacidil; Potassium Channel Blockers; Pregnancy; Rats; Rats, Sprague-Dawley; Ritodrine; Salmeterol Xinafoate; Sulfonylurea Receptors; Tocolytic Agents | 2015 |
Molecular analysis of ATP-sensitive K(+) channel subunits expressed in mouse portal vein.
Topics: Adamantane; Animals; Glyburide; Imidazoles; KATP Channels; Male; Mice; Mice, Inbred BALB C; Morpholines; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Patch-Clamp Techniques; Pinacidil; Portal Vein; Real-Time Polymerase Chain Reaction; Sulfonylurea Receptors; Thioamides | 2015 |
Isosteviol Sensitizes sarcKATP Channels towards Pinacidil and Potentiates Mitochondrial Uncoupling of Diazoxide in Guinea Pig Ventricular Myocytes.
Topics: Acetylcysteine; Action Potentials; Animals; Calcium Channels, L-Type; Diazoxide; Diterpenes, Kaurane; Flavoproteins; Fluorescence; Glyburide; Guinea Pigs; Heart Ventricles; Ion Channel Gating; KATP Channels; Mitochondria; Myocytes, Cardiac; Oxidation-Reduction; Pinacidil; Reactive Oxygen Species; Sarcolemma; Time Factors | 2016 |
In vitro effect of nicorandil on the carbachol-induced contraction of the lower esophageal sphincter of the rat.
Topics: Animals; Carbachol; Diazoxide; Dose-Response Relationship, Drug; Esophageal Sphincter, Lower; Glyburide; In Vitro Techniques; KATP Channels; Muscle Contraction; NG-Nitroarginine Methyl Ester; Nicorandil; Oxadiazoles; Peptides; Pinacidil; Potassium; Quinoxalines; Rats | 2016 |
Roles of ATP sensitive potassium channel in modulating gastric tone and accommodation in dogs.
Topics: Animals; Dogs; Female; Gastrointestinal Motility; Glyburide; KATP Channels; Myocytes, Smooth Muscle; Pinacidil; Stomach; Vasodilation | 2017 |
The Opening of ATP-Sensitive K+ Channels Protects H9c2 Cardiac Cells Against the High Glucose-Induced Injury and Inflammation by Inhibiting the ROS-TLR4-Necroptosis Pathway.
Topics: Acetylcysteine; Animals; Apoptosis; Cell Line; Decanoic Acids; Diazoxide; Gene Expression Regulation; Glucose; Glyburide; Hydroxy Acids; Imidazoles; Indoles; Membrane Potential, Mitochondrial; Myocytes, Cardiac; Necrosis; Oxidative Stress; Pinacidil; Potassium Channels; Rats; Reactive Oxygen Species; Receptor-Interacting Protein Serine-Threonine Kinases; Signal Transduction; Sulfonamides; Toll-Like Receptor 4 | 2017 |
Hypoxia augments NaHS-induced ANP secretion via KATP channel, HIF-1α and PPAR-γ pathway.
Topics: 2-Methoxyestradiol; Anilides; Animals; Atrial Natriuretic Factor; Bosentan; Gene Expression Regulation; Glyburide; Heart Atria; Hydrogen Sulfide; Hypertension, Pulmonary; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; KATP Channels; Male; Monocrotaline; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase Type III; Organ Culture Techniques; Oxygen; Pinacidil; Potassium Channel Blockers; PPAR gamma; Rats; Rats, Sprague-Dawley; Signal Transduction; Sulfides | 2019 |