Page last updated: 2024-08-16

pinacidil and diazoxide

pinacidil has been researched along with diazoxide in 121 studies

Research

Studies (121)

Timeframe	Studies, this research(%)	All Research%
pre-1990	5 (4.13)	18.7374
1990's	33 (27.27)	18.2507
2000's	54 (44.63)	29.6817
2010's	29 (23.97)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Andres, H; Bray, K; Manley, PW; Quast, U	1
Higashiguchi, O; Horio, Y; Isomoto, S; Kondo, C; Kurachi, Y; Matsumoto, S; Matsuzawa, Y; Yamada, M	1
Horio, Y; Isomoto, S; Kondo, C; Kurachi, Y; Matsumoto, S; Shindo, T; Yamada, M	1
Boverie, S; Damas, J; de Tullio, P; Dupont, L; Fontaine, J; Khelili, S; Lebrun, P; Ouedraogo, R; Pirotte, B; Somers, F	1
Agerholm, PC; Arkhammar, PO; Hansen, JB; Mogensen, JP; Tagmose, TM; Wahl, P; Worsaae, A	1
Antoine, MH; Becker, B; Damas, J; de Tullio, P; Delarge, J; Dupont, L; Fontaine, J; Lebrun, P; Ouedraogo, R; Pirotte, B; Rigo, B; Somers, F	1
Antoine, MH; Becker, B; Boverie, S; Dabrowski, M; de Tullio, P; Hansen, JB; Lebrun, P; Ouedraogo, R; Pirotte, B; Sebille, S; Somers, F; Wahl, P	1
Antoine, MH; Arkhammar, PO; Boonen, HC; Hansen, BS; Hansen, JB; Lebrun, P; Mogensen, JP; Nielsen, FE; Schou, SC; Tagmose, TM; Wahl, P; Worsaae, A	1
Antoine, MH; Becker, B; Boverie, S; de Tullio, P; Lebrun, P; Pirotte, B; Sebille, S	1
Bellows, DS; Clarke, ID; Diamandis, P; Dirks, PB; Graham, J; Jamieson, LG; Ling, EK; Sacher, AG; Tyers, M; Ward, RJ; Wildenhain, J	1
Antoine, MH; Becker, B; de Tullio, P; Florence, X; Lebrun, P; Michaux, C; Pirotte, B; Sebille, S; Wouters, J	1
Abdelaziz, S; Bouhadja, M; de Tullio, P; Florence, X; Khelili, S; Lebrun, P; Mechouch, N; Mohamed, Y; Pirotte, B	1
Balsamo, A; Bianucci, AM; Calderone, V; Coi, A; Digiacomo, M; Rapposelli, S; Testai, L	1
Florence, X; Lebrun, P; Pirotte, B; Sebille, S; Tullio, Pd	1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A	1
Boverie, S; de Tullio, P; Lebrun, P; Michaux, C; Pirotte, B	1
de Tullio, P; Khelili, S; Kihal, N; Lebrun, P; Pirotte, B; Yekhlef, M	1
Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ	1
Bouider, N; de Tullio, P; Faury, G; Goffin, E; Harrouche, K; Khelili, S; Lebrun, P; Pirotte, B; Renard, JF	1
Brodsky, JL; Chiang, A; Chung, WJ; Denny, RA; Goeckeler-Fried, JL; Havasi, V; Hong, JS; Keeton, AB; Mazur, M; Piazza, GA; Plyler, ZE; Rasmussen, L; Rowe, SM; Sorscher, EJ; Weissman, AM; White, EL	1
Ashford, ML; Boden, PR; Sellers, AJ	1
Kato, H; Shimada, F; Takata, Y	1
Antoine, MH; Herchuelz, A; Lebrun, P	1
Dunne, MJ	1
Fontaine, J; Lebrun, P	1
Brayden, JE; Davies, NW; Huang, Y; Nelson, MT; Quayle, JM; Standen, NB	1
Devreux, V; Herchuelz, A; Hermann, M; Lebrun, P	1
Garrino, MG; Henquin, JC; Plant, TD	2
Eggertsen, R; Hansson, L	1
de Tullio, P; Delarge, J; Dupont, L; Masereel, B; Pirotte, B	1
Abrahams, Z; Sutter, MC	1
Attolini, L; Bruguerolle, B; Gantenbein, M	1
Link, H; Mix, E; Olsson, T; Zhu, J	1
Atwal, KS	1
Clapham, JC; Hamilton, TC; Trail, BK	1
Ducote, J; Harmon, CS; Lutz, D	1
Antoine, MH; de Tullio, P; Delarge, J; Dunne, M; Herchuelz, A; Hermann, M; Kane, C; Lebrun, P; Masereel, B; Ouedraogo, R; Pirotte, B	1
Goodman, Y; Mattson, MP	1
Matsumura, K; Mochizuki-Oda, N; Oosawa, Y; Takeuchi, Y; Watanabe, Y	1
Daut, J; Langheinrich, U	1
Albert, A; De Tullio, P; Delarge, J; Dresse, A; Massotte, L; Pirotte, B; Scuvée-Moreau, J; Seutin, V; Vrijens, B	1
Hori, M; Horio, Y; Isomoto, S; Kitakaze, M; Kondo, C; Kurachi, Y; Okuyama, Y; Satoh, E; Shindo, T; Yamada, M	1
Grimmsmann, T; Rustenbeck, I	1
Antoine, MH; de Tullio, P; Delarge, J; Herchuelz, A; Lebrun, P; Ouedraogo, R; Pirotte, B	1
Beattie, DK; Davies, AH; Gosling, M; Powell, JT	1
Aguilar-Bryan, L; Bryan, J; Dörschner, H; Gross, I; Schwanstecher, C; Schwanstecher, M; Sieverding, C	1
Aguilar-Bryan, L; Babenko, AP; Bryan, J; Gonzalez, G	1
Seki, T; Sperelakis, N; Sunagawa, M; Yokoshiki, H	1
Baines, CP; Birincioglu, M; Cohen, MV; Critz, SD; Downey, JM; Liu, GS	1
Plujà, L; Sperelakis, N; Yokoshiki, H	1
Holmuhamedov, EL; Terzic, A; Wang, L	1
Gonoi, T; Inagaki, N; Ishida, H; Seino, S; Seino, Y; Sunaga, Y; Yamada, Y	1
Foldes, FF; Matkó, I; Nagashima, H; Oe, K; Sántha, E; Sperlágh, B; Vizi, ES	1
Ammälä, C; Chapman, JC; Cosgrove, KE; Dunne, MJ; Flatt, PR; Giesberts, AN; Hashmi, MN; McClenaghan, NH; Shepherd, RM; White, SJ	1
Dallaporta, M; Orsini, JC; Perrin, J	1
Marbán, E; O'Rourke, B; Ohler, A; Sasaki, N; Sato, T	1
Granda, B; Medina, JM; Tabernero, A; Velasco, A	1
Galiñanes, M; Ghosh, S; Standen, NB	1
Firth, TA; Mawe, GM; Nelson, MT	1
D'hahan, N; Jacquet, H; Moreau, C; Prost, AL; Vivaudou, M	1
Ashcroft, FM; Gribble, FM	1
Garlid, KD; Kowaltowski, AJ; Paucek, P; Seetharaman, S	1
Liu, Y; Marbán, E; O'Rourke, B; Ren, G; Seharaseyon, J	1
Li, RA; Marbán, E; Miki, T; Nakaya, H; Ogura, T; Ohmoto-Sekine, Y; Sakamoto, N; Seino, S; Suzuki, M; Tamagawa, M; Uemura, H	1
Akao, M; Marbán, E; O'Rourke, B; Ohler, A	1
Bielfeld-Ackermann, A; Konstas, AA; Korbmacher, C	1
Jovaisiene, J; Kopustinskiene, DM; Liobikas, J; Toleikis, A	1
Grover, GJ; Jilkina, O; Kupriyanov, VV; Kuzio, B	1
Englert, H; Kilbinger, H; Krause, A; Mang, CF; Wirth, K	1
Buettner, GR; Hunninghake, GW; Monick, MM; Oberley, LW; Samavati, L; Sanlioglu, S	1
Han, J; Joo, H; Kim, E; Kim, N	1
Brandt, U; Daut, J; Hanley, PJ; Löffler, M; Mickel, M	1
Benoit, JN; Cohen, MV; Critz, SD; Downey, JM; Garlid, KD; Krenz, M; Oldenburg, O; Wimpee, H	1
Houston, RJ; Legtenberg, RJ; Oeseburg, B; Rongen, GA; Smits, P	1
Cartier, EA; Shen, S; Shyng, SL	1
Boonen, HC; Hansen, JB; Jensen, AF; Mogensen, JP; Nielsen, FE; Tagmose, TM; Worsaae, A; Zaragoza, F	1
Hogan, Q; Kwok, WM; McCallum, B; Sapunar, D; Sarantopoulos, C	1
Kato, Y; Koshimura, K; Murakami, Y; Tanaka, J	1
Kopustinskiene, DM; Saris, NE; Toleikis, A	1
Kawano, T; Kitahata, H; Kuroda, Y; Nakaya, Y; Oshita, S; Takahashi, A; Tomiyama, Y; Tsutsumi, Y	1
Colombini, M; Holmuhamedov, EL; Jahangir, A; Komarov, A; Oberlin, A; Terzic, A	1
Miki, T; Miura, T	1
Er, F; Gassanov, N; Hoppe, UC; Michels, G; Rivero, F	1
Kobayashi, T; Ohta, Y	1
Dérand, R; Moreau, C; Prost, AL; Vivaudou, M	1
Gruchała, M; Kocić, I; Petrusewicz, J	1
Borne, J; Frame, MD; Mabanta, L; Valane, P	1
Acevedo, JJ; Darszon, A; de la Vega-Beltrán, JL; Felix, R; Mendoza-Lujambio, I; Treviño, CL	1
Gao, M; Wang, H; Wang, Y	1
Flores-Murrieta, FJ; Granados-Soto, V; Mixcoatl-Zecuatl, T	1
Aishima, M; Ito, Y; Naito, S; Nakano, T; Seki, N; Sueishi, K; Teramoto, N; Tomoda, T; Yonemitsu, Y; Yunoki, T	1
Sung, RJ; Wu, AZ; Wu, SN	1
Amaral, A; Cao, C; Chu, W; Healey, S; Kouttab, N; Lee-Couture, A; Wan, S; Wan, Y	1
Camara, AK; Eells, JT; Heinen, A; Henry, MM; Riess, ML; Stowe, DF	1
Adebiyi, A; Jaggar, JH; McNally, EM	1
Davison, AS; Hine, TJ; Holmes, E; Roberts, NB; Sodi, R	1
Bondarenko, OI	1
Efimov, IR; Fedorov, VV; Flagg, TP; Glukhov, AV; Nichols, CG	1
Ding, J; Duan, L; Hu, G; Huang, X; Qian, X; Xie, J	1
Andrade, F; Huerta, M; Montoya-Pérez, R; Ortiz, M; Saavedra-Molina, A; Sánchez-Pastor, E; Trujillo, X	1
Kopustinskiene, DM; Liobikas, J; Malinauskas, F; Skemiene, K; Toleikis, A	1
Henquin, JC; Nenquin, M; Szollosi, A	1
Chan, M; Ingebrandt, S; Law, JK; Rudd, JA; Yeung, CK; Yiu, KL	1
Bozdogan, O; Gonca, E	1
Al-Dadah, AS; Lawton, JS; Maffit, SK; Nichols, CG; Schuessler, RB; Sellitto, AD; Zhang, H	1
Akrouh, A; Kurata, HT; Lawton, JS; Nichols, CG; Remedi, MS; Zhang, HX	1
Ducza, E; Falkay, G; Gaspar, R; Lovasz, N	2
Du, X; Wang, C; Zhang, H	1
Ambrosi, CM; Chang, R; Efimov, IR; Fedorov, VV; Glukhov, AV; Janks, D; Kostecki, G; Moazami, N; Nichols, CG; Schuessler, RB	1
de Tullio, P; Dilly, S; Florence, X; Lebrun, P; Pirotte, B	1
de Araujo, ED; Kanelis, V; López-Alonso, JP	1
Kanter, EM; Lee, US; Lin, YW; Nichols, CG; Schuessler, RB; Silva, JR; Verbsky, JW; Yamada, KA; Zhang, HX	1
Billman, GE	1
Behmoaras, J; Buján, J; Escoubet, B; Jacob, MP; Lacolley, P; Lannoy, M; Pezet, M; Sloboda, N; Slove, S	1
Brennan, S; Hudman, D; Jackson, R; Lodwick, D; Norman, RI; Patel, M; Rainbow, RD; Sims, MW	1
Brailovskaya, IV; Emelyanova, LV; Korotkov, SM; Shumakov, AR	1
Chen, Y; Fan, Z; Huang, L; Lin, W; Tan, W; Wen, T; Yin, C	1
Adachi, T; Fujisawa, S; Hongoh, M; Ohba, T; Ono, K; Shimbo, T	1
Chen, M; Feng, J; Lan, J; Li, J; Liang, W; Song, M; Zhang, W; Zheng, D	1

Reviews

5 review(s) available for pinacidil and diazoxide

Article	Year
Vasodilators in hypertension--a review with special emphasis on the combined use of vasodilators and beta-adrenoceptor blockers. International journal of clinical pharmacology, therapy, and toxicology, 1985, Volume: 23, Issue:8 Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Angiotensin-Converting Enzyme Inhibitors; Calcium Channel Blockers; Carbazoles; Carvedilol; Diazoxide; Dihydralazine; Drug Therapy, Combination; Glomerular Filtration Rate; Guanidines; Humans; Hydralazine; Hypertension; Minoxidil; Pinacidil; Plasma Volume; Propanolamines; Pyridazines; Renin-Angiotensin System; Serotonin Antagonists; Vascular Resistance; Vasodilator Agents	1985
Pharmacology and structure-activity relationships for KATP modulators: tissue-selective KATP openers. Journal of cardiovascular pharmacology, 1994, Volume: 24 Suppl 4 Topics: Action Potentials; Adenosine Triphosphate; Animals; Antihypertensive Agents; Benzopyrans; Cardiovascular Diseases; Cromakalim; Diazoxide; Guanidines; Guinea Pigs; Minoxidil; Muscle Relaxation; Muscle, Smooth, Vascular; Niacinamide; Nicorandil; Picolines; Pinacidil; Potassium Channels; Pyrans; Pyrroles; Radioligand Assay; Rats; Structure-Activity Relationship; Vasodilator Agents	1994
New windows on the mechanism of action of K(ATP) channel openers. Trends in pharmacological sciences, 2000, Volume: 21, Issue:11 Topics: Adenosine Triphosphate; Animals; Binding Sites; Cromakalim; Diazoxide; Humans; Minoxidil; Nicorandil; Pinacidil; Potassium Channels	2000
ATP-sensitive K+ channel openers: old drugs with new clinical benefits for the heart. Current vascular pharmacology, 2003, Volume: 1, Issue:3 Topics: Adenosine Triphosphate; Animals; Coronary Circulation; Coronary Disease; Diazoxide; Glyburide; Humans; Ion Channel Gating; Myocardial Reperfusion Injury; Nicorandil; Pinacidil; Potassium Channel Blockers; Potassium Channels; Randomized Controlled Trials as Topic; Vasodilator Agents	2003
SUR, ABC proteins targeted by KATP channel openers. Journal of molecular and cellular cardiology, 2005, Volume: 38, Issue:6 Topics: Adenosine Triphosphate; Animals; ATP-Binding Cassette Transporters; Cromakalim; Cytoplasm; Diazoxide; Down-Regulation; Humans; KATP Channels; Models, Biological; Pinacidil; Potassium Channels; Potassium Channels, Inwardly Rectifying; Protein Binding; Protein Isoforms; Protein Structure, Secondary; Protein Structure, Tertiary; Receptors, Drug; Sulfonylurea Receptors; Up-Regulation	2005

Other Studies

116 other study(ies) available for pinacidil and diazoxide

Article	Year
Synthesis of and radioligand binding studies with a tritiated pinacidil analogue: receptor interactions of structurally different classes of potassium channel openers and blockers. Journal of medicinal chemistry, 1993, Jul-09, Volume: 36, Issue:14 Topics: Animals; Binding Sites; Drug Interactions; Guanidines; Muscle, Smooth, Vascular; Pinacidil; Potassium Channels; Pyridines; Rats; Structure-Activity Relationship; Vasodilator Agents	1993
A novel sulfonylurea receptor forms with BIR (Kir6.2) a smooth muscle type ATP-sensitive K+ channel. The Journal of biological chemistry, 1996, Oct-04, Volume: 271, Issue:40 Topics: Adenosine Triphosphate; Amino Acid Sequence; Animals; ATP-Binding Cassette Transporters; Base Sequence; Cell Line; Cloning, Molecular; DNA, Complementary; Humans; Mice; Molecular Sequence Data; Muscle, Smooth; Potassium Channels; Potassium Channels, Inwardly Rectifying; Rats; Receptors, Drug; Sulfonylurea Receptors	1996
Sulphonylurea receptor 2B and Kir6.1 form a sulphonylurea-sensitive but ATP-insensitive K+ channel. The Journal of physiology, 1997, Mar-15, Volume: 499 ( Pt 3) Topics: Adenosine Triphosphate; Animals; ATP-Binding Cassette Transporters; Cloning, Molecular; Glyburide; Guanidines; Guanosine Diphosphate; Guanosine Triphosphate; Hypoglycemic Agents; KATP Channels; Macromolecular Substances; Magnesium; Mice; Molecular Sequence Data; Muscle, Smooth, Vascular; Niacinamide; Nicorandil; Patch-Clamp Techniques; Pinacidil; Potassium Channels; Potassium Channels, Inwardly Rectifying; Receptors, Drug; Sulfonylurea Compounds; Sulfonylurea Receptors; Uridine Diphosphate; Vasodilator Agents	1997
3-Alkylamino-4H-pyrido[2,3-e]-1,2,4-thiadiazine 1,1-dioxides structurally related to diazoxide and pinacidil as potassium channel openers acting on vascular smooth muscle cells: design, synthesis, and pharmacological evaluation. Journal of medicinal chemistry, 2000, Apr-20, Volume: 43, Issue:8 Topics: Animals; Aorta; Cyclic S-Oxides; Diazoxide; Drug Design; Female; Guinea Pigs; Ileum; In Vitro Techniques; Insulin; Insulin Secretion; Islets of Langerhans; Muscle Contraction; Muscle, Smooth, Vascular; Pinacidil; Potassium Channels; Rats; Rats, Wistar; Structure-Activity Relationship; Thiadiazines; Uterine Contraction; Vasodilator Agents	2000
Phenylcyanoguanidines as inhibitors of glucose-induced insulin secretion from beta cells. Bioorganic & medicinal chemistry letters, 2001, Jul-09, Volume: 11, Issue:13 Topics: Cell Line; Glucose; Guanidines; Humans; In Vitro Techniques; Insulin; Insulin Antagonists; Insulin Secretion; Islets of Langerhans	2001
Original 2-alkylamino-6-halogenoquinazolin-4(3H)-ones and K(ATP) channel activity. Journal of medicinal chemistry, 2001, Aug-02, Volume: 44, Issue:16 Topics: Adenosine Triphosphate; Animals; Aorta; Calcium; Crystallography, X-Ray; Female; Glyburide; Guinea Pigs; Ileum; In Vitro Techniques; Insulin; Insulin Secretion; Islets of Langerhans; Muscle Contraction; Muscle, Smooth; Potassium Channels; Potassium Chloride; Quinazolines; Rats; Rats, Wistar; Rubidium; Structure-Activity Relationship; Uterine Contraction; Uterus	2001
Toward tissue-selective pancreatic B-cells KATP channel openers belonging to 3-alkylamino-7-halo-4H-1,2,4-benzothiadiazine 1,1-dioxides. Journal of medicinal chemistry, 2003, Jul-17, Volume: 46, Issue:15 Topics: Adenosine Triphosphate; Animals; Aorta; Benzothiadiazines; Diazoxide; Female; Glucose; In Vitro Techniques; Insulin; Insulin Secretion; Ion Channel Gating; Islets of Langerhans; Isomerism; Molecular Conformation; Muscle Relaxation; Muscle, Smooth, Vascular; Oocytes; Organ Specificity; Patch-Clamp Techniques; Potassium Channels; Rats; Rats, Wistar; Structure-Activity Relationship; Xenopus laevis	2003
Arylcyanoguanidines as activators of Kir6.2/SUR1K ATP channels and inhibitors of insulin release. Journal of medicinal chemistry, 2004, Jun-03, Volume: 47, Issue:12 Topics: Animals; Aorta; ATP-Binding Cassette Transporters; Cell Line; Female; Glucose; Guanidines; Humans; In Vitro Techniques; Insulin Antagonists; Islets of Langerhans; Male; Mitochondria; Muscle Relaxation; Muscle, Smooth, Vascular; Nitriles; Oocytes; Oxidation-Reduction; Patch-Clamp Techniques; Potassium Channels; Potassium Channels, Inwardly Rectifying; Rats; Rats, Sprague-Dawley; Receptors, Drug; Structure-Activity Relationship; Sulfonylurea Receptors; Xenopus laevis	2004
4,6-Disubstituted 2,2-dimethylchromans structurally related to the K(ATP) channel opener cromakalim: design, synthesis, and effect on insulin release and vascular tone. Journal of medicinal chemistry, 2005, Jan-27, Volume: 48, Issue:2 Topics: Animals; Aorta, Thoracic; Chromans; Cromakalim; In Vitro Techniques; Insulin; Insulin Secretion; Ion Channel Gating; Islets of Langerhans; Muscle, Smooth, Vascular; Potassium Channels; Rats; Rats, Wistar; Structure-Activity Relationship; Vasodilator Agents	2005
Chemical genetics reveals a complex functional ground state of neural stem cells. Nature chemical biology, 2007, Volume: 3, Issue:5 Topics: Animals; Cell Survival; Cells, Cultured; Mice; Molecular Structure; Neoplasms; Neurons; Pharmaceutical Preparations; Sensitivity and Specificity; Stem Cells	2007
New R/S-3,4-dihydro-2,2-dimethyl-6-halo-4-(phenylaminothiocarbonylamino)-2H-1-benzopyrans structurally related to (+/-)-cromakalim as tissue-selective pancreatic beta-cell K(ATP) channel openers. Bioorganic & medicinal chemistry, 2008, May-15, Volume: 16, Issue:10 Topics: Animals; Aorta; ATP-Binding Cassette Transporters; Benzopyrans; Cromakalim; Diazoxide; Drug Evaluation, Preclinical; Insulin-Secreting Cells; Molecular Structure; Pinacidil; Potassium Channels; Quantum Theory; Rats; Rats, Wistar; Stereoisomerism; Structure-Activity Relationship; Temperature; Time Factors	2008
Synthesis and activity on rat aorta rings and rat pancreatic beta-cells of ring-opened analogues of benzopyran-type potassium channel activators. Bioorganic & medicinal chemistry, 2008, Jun-01, Volume: 16, Issue:11 Topics: Animals; Aorta; Benzopyrans; Chromans; Cromakalim; In Vitro Techniques; Insulin; Insulin Antagonists; Insulin Secretion; Insulin-Secreting Cells; Muscle Relaxation; Potassium Channels; Rats; Rats, Wistar	2008
Predictive models, based on classification algorithms, for compounds potentially active as mitochondrial ATP-sensitive potassium channel openers. Bioorganic & medicinal chemistry, 2009, Aug-01, Volume: 17, Issue:15 Topics: Algorithms; Benzopyrans; Cardiotonic Agents; KATP Channels; Models, Chemical; Molecular Structure; Quantitative Structure-Activity Relationship; Spiro Compounds	2009
New R/S-3,4-dihydro-2,2-dimethyl-2H-1-benzopyrans as K(ATP) channel openers: modulation of the 4-position. Bioorganic & medicinal chemistry, 2009, Nov-15, Volume: 17, Issue:22 Topics: Adenosine Triphosphate; Animals; Benzopyrans; Cromakalim; Diazoxide; Islets of Langerhans; Muscle, Smooth, Vascular; Pinacidil; Potassium Channels; Rats; Rats, Wistar; Stereoisomerism; Structure-Activity Relationship; Vasodilator Agents	2009
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Chemical research in toxicology, 2010, Volume: 23, Issue:1 Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship	2010
Impact of the nature of the substituent at the 3-position of 4H-1,2,4-benzothiadiazine 1,1-dioxides on their opening activity toward ATP-sensitive potassium channels. Journal of medicinal chemistry, 2011, May-12, Volume: 54, Issue:9 Topics: Animals; Aorta; Benzothiadiazines; Diazoxide; Female; Hydrogen Bonding; Hydrogen-Ion Concentration; In Vitro Techniques; Insulin; Insulin Secretion; Insulin-Secreting Cells; Ion Channel Gating; KATP Channels; Models, Molecular; Molecular Conformation; Muscle Contraction; Muscle Relaxation; Muscle, Smooth; Rats; Rats, Wistar; Stereoisomerism; Structure-Activity Relationship; Uterus	2011
Synthesis and pharmacological activity of N-(2,2-dimethyl-3,4-dihydro-2H-1-benzopyran-4-yl)-4H-1,2,4-benzothiadiazine-3-carboxamides 1,1-dioxides on rat uterus, rat aorta and rat pancreatic β-cells. European journal of medicinal chemistry, 2012, Volume: 54 Topics: Animals; Aorta; Benzothiadiazines; Chemistry Techniques, Synthetic; Female; In Vitro Techniques; Insulin; Insulin Secretion; Insulin-Secreting Cells; Muscle Relaxation; Muscle, Smooth; Rats; Uterus	2012
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification. Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:12 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship	2012
Synthesis, characterization and biological evaluation of benzothiazoles and tetrahydrobenzothiazoles bearing urea or thiourea moieties as vasorelaxants and inhibitors of the insulin releasing process. European journal of medicinal chemistry, 2016, Jun-10, Volume: 115 Topics: Animals; Benzothiazoles; Female; Insulin; Insulin Secretion; Rats; Rats, Wistar; Urea; Vasodilator Agents	2016
Increasing the Endoplasmic Reticulum Pool of the F508del Allele of the Cystic Fibrosis Transmembrane Conductance Regulator Leads to Greater Folding Correction by Small Molecule Therapeutics. PloS one, 2016, Volume: 11, Issue:10 Topics: Alleles; Benzoates; Cells, Cultured; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Endoplasmic Reticulum; Furans; Gene Deletion; HEK293 Cells; HeLa Cells; High-Throughput Screening Assays; Humans; Hydroxamic Acids; Microscopy, Fluorescence; Protein Folding; Protein Structure, Tertiary; Pyrazoles; RNA, Messenger; Small Molecule Libraries; Ubiquitination; Vorinostat	2016
Lack of effect of potassium channel openers on ATP-modulated potassium channels recorded from rat ventromedial hypothalamic neurones. British journal of pharmacology, 1992, Volume: 107, Issue:4 Topics: Adenosine Triphosphate; Animals; Benzopyrans; Calcium; Cromakalim; Diazoxide; Guanidines; Hypothalamus, Middle; In Vitro Techniques; Male; Membrane Potentials; Minoxidil; Neurons; Pinacidil; Potassium Channels; Pyrroles; Rats; Rats, Sprague-Dawley; Vasodilator Agents	1992
Differential effects of diazoxide, cromakalim and pinacidil on adrenergic neurotransmission and 86Rb+ efflux in rat brain cortical slices. The Journal of pharmacology and experimental therapeutics, 1992, Volume: 263, Issue:3 Topics: Animals; Benzopyrans; Cerebral Cortex; Cocaine; Cromakalim; Diazoxide; Electric Stimulation; Glyburide; Guanidines; Hydrocortisone; In Vitro Techniques; Male; Norepinephrine; Pinacidil; Potassium Channels; Pyrroles; Rats; Rats, Wistar; Rubidium Radioisotopes	1992
Anoxia and glucose-sensitive 86Rb outflow from rat portal vein. Pharmacology, 1992, Volume: 44, Issue:2 Topics: Adenosine Triphosphate; Animals; Benzopyrans; Cromakalim; Diazoxide; Glucose; Guanidines; Hypoxia; Permeability; Pinacidil; Portal Vein; Potassium; Potassium Channels; Pyrroles; Rats; Rats, Inbred Strains; Rubidium Radioisotopes	1992
Effects of pinacidil, RP 49356 and nicorandil on ATP-sensitive potassium channels in insulin-secreting cells. British journal of pharmacology, 1990, Volume: 99, Issue:3 Topics: Adenoma, Islet Cell; Adenosine Triphosphate; Diazoxide; Glucose; Guanidines; Humans; Insulin; Insulinoma; Islets of Langerhans; Membrane Potentials; Niacinamide; Nicorandil; Pancreatic Neoplasms; Picolines; Pinacidil; Potassium Channels; Pyrans; Rubidium Radioisotopes; Tumor Cells, Cultured	1990
Relaxation response to pinacidil and diazoxide in the mouse isolated distal colon. Pharmacology, 1990, Volume: 40, Issue:1 Topics: Animals; Colon; Diazoxide; Dose-Response Relationship, Drug; Guanidines; Mice; Muscle Contraction; Muscle Relaxation; Muscle, Smooth; Pinacidil; Sulfonylurea Compounds; Vasodilator Agents	1990
Hyperpolarizing vasodilators activate ATP-sensitive K+ channels in arterial smooth muscle. Science (New York, N.Y.), 1989, Jul-14, Volume: 245, Issue:4914 Topics: Acetylcholine; Adenosine Triphosphate; Animals; Benzopyrans; Cerebral Arteries; Cromakalim; Diazoxide; Glyburide; Guanidines; Mesenteric Arteries; Muscle, Smooth, Vascular; Pinacidil; Potassium Channels; Pyrroles; Rabbits; Rats; Tolbutamide; Vasoactive Intestinal Peptide; Vasodilator Agents	1989
Similarities between the effects of pinacidil and diazoxide on ionic and secretory events in rat pancreatic islets. The Journal of pharmacology and experimental therapeutics, 1989, Volume: 250, Issue:3 Topics: Animals; Calcimycin; Calcium; Cell Membrane Permeability; Diazoxide; Glucose; Guanidines; In Vitro Techniques; Insulin; Insulin Secretion; Islets of Langerhans; Pinacidil; Potassium; Rats; Rubidium; Secretory Rate; Tolbutamide	1989
Comparison of the effects of putative activators of K+ channels on pancreatic B-cell function. Pflugers Archiv : European journal of physiology, 1989, Volume: 414 Suppl 1 Topics: Animals; Benzopyrans; Cromakalim; Diazoxide; Guanidines; In Vitro Techniques; Islets of Langerhans; Mice; Minoxidil; Niacinamide; Nicorandil; Pinacidil; Potassium Channels; Pyrroles; Vasodilator Agents	1989
Effects of putative activators of K+ channels in mouse pancreatic beta-cells. British journal of pharmacology, 1989, Volume: 98, Issue:3 Topics: Adenosine Triphosphate; Animals; Benzopyrans; Cromakalim; Diazoxide; Electrophysiology; Female; Glucose; Guanidines; Homeostasis; In Vitro Techniques; Insulin; Insulin Secretion; Islets of Langerhans; Membrane Potentials; Mice; Minoxidil; Niacinamide; Nicorandil; Pinacidil; Potassium Channels; Pyrroles; Rubidium Radioisotopes	1989
[Potassium channel activators: comparative structural study of pinacidil, diazoxide and cromakalim]. Annales pharmaceutiques francaises, 1995, Volume: 53, Issue:5 Topics: Antihypertensive Agents; Benzopyrans; Cromakalim; Diazoxide; Guanidines; Molecular Conformation; Molecular Structure; Pinacidil; Potassium Channels; Pyrroles	1995
Effects of K+ channel openers on the vascular actions of human gamma globulin. European journal of pharmacology, 1994, Feb-03, Volume: 252, Issue:2 Topics: Animals; Diazoxide; gamma-Globulins; Glyburide; Guanidines; Humans; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth, Vascular; Norepinephrine; Pinacidil; Portal Vein; Potassium Channels; Rats; Rats, Wistar; Vasodilator Agents	1994
Effect of four potassium channel agonists on bupivacaine-induced toxicity in mice. Life sciences, 1995, Volume: 57, Issue:10 Topics: Animals; Benzopyrans; Bupivacaine; Cromakalim; Diazoxide; Dose-Response Relationship, Drug; Guanidines; Male; Mice; Mice, Inbred Strains; Niacinamide; Nicorandil; Pinacidil; Potassium Channels; Pyrroles; Seizures	1995
Influence of K+ channel openers on interferon-gamma dependent immune response in experimental allergic neuritis (EAN). Autoimmunity, 1994, Volume: 18, Issue:4 Topics: Animals; Benzopyrans; Cromakalim; Diazoxide; Guanidines; Interferon-gamma; Ion Channel Gating; Lymph Nodes; Lymphocyte Activation; Neuritis, Autoimmune, Experimental; Pinacidil; Potassium Channels; Pyrroles; Rats; Rats, Inbred Lew	1994
K+ channel activators, acute glucose tolerance and glibenclamide-induced hypoglycaemia in the hypertensive rat. European journal of pharmacology, 1994, May-12, Volume: 257, Issue:1-2 Topics: Administration, Oral; Animals; Antihypertensive Agents; Benzopyrans; Blood Glucose; Blood Pressure; Cromakalim; Diazoxide; Dose-Response Relationship, Drug; Glucose Tolerance Test; Glyburide; Guanidines; Hypertension; Hypoglycemia; Pinacidil; Potassium Channels; Pyrroles; Rats; Rats, Inbred SHR	1994
Potassium channel openers stimulate DNA synthesis in mouse epidermal keratinocyte and whole hair follicle cultures. Skin pharmacology : the official journal of the Skin Pharmacology Society, 1993, Volume: 6, Issue:3 Topics: Animals; Benzopyrans; Cells, Cultured; Cromakalim; Diazoxide; DNA; Guanidines; Hair; Keratinocytes; Kinetics; Mice; Minoxidil; Pinacidil; Potassium Channels; Pyrroles; Vibrissae	1993
Activation of ATP-dependent K+ channels and inhibition of insulin release: effect of BPDZ 62. The Journal of pharmacology and experimental therapeutics, 1996, Volume: 277, Issue:1 Topics: Adenosine Triphosphate; Animals; Calcium; Diazoxide; Guanidines; Insulin; Insulin Secretion; Islets of Langerhans; Perfusion; Pinacidil; Potassium Channels; Potassium Chloride; Pyridines; Rats; Thiadiazines	1996
K+ channel openers protect hippocampal neurons against oxidative injury and amyloid beta-peptide toxicity. Brain research, 1996, Jan-15, Volume: 706, Issue:2 Topics: Amyloid beta-Peptides; Animals; Calcium Channel Agonists; Cells, Cultured; Diazoxide; Ferric Compounds; Guanidines; Hippocampus; Hydrogen Peroxide; Neurons; Neuroprotective Agents; Organic Chemicals; Oxidation-Reduction; Pinacidil; Rats	1996
Hypoxia-induced catecholamine release and intracellular Ca2+ increase via suppression of K+ channels in cultured rat adrenal chromaffin cells. Journal of neurochemistry, 1997, Volume: 69, Issue:1 Topics: Animals; Benzopyrans; Buffers; Calcium; Carotid Body; Catecholamines; Cell Hypoxia; CHO Cells; Chromaffin Cells; Cricetinae; Cromakalim; Diazoxide; Glioma; Glyburide; Guanidines; Hybrid Cells; Hypoglycemic Agents; Male; Membrane Potentials; Minoxidil; Neuroblastoma; Parasympatholytics; Patch-Clamp Techniques; Pinacidil; Potassium; Potassium Channel Blockers; Potassium Channels; Pyrroles; Rats; Rats, Wistar; Vasodilator Agents	1997
Hyperpolarization of isolated capillaries from guinea-pig heart induced by K+ channel openers and glucose deprivation. The Journal of physiology, 1997, Jul-15, Volume: 502 ( Pt 2) Topics: Adenosine Triphosphate; Animals; Barbiturates; Capillaries; Chromans; Coronary Circulation; Diazoxide; Fluorescent Dyes; Glucose; Glyburide; Gramicidin; Guanidines; Guinea Pigs; In Vitro Techniques; Isoxazoles; Membrane Potentials; Muscle, Smooth, Vascular; Osmolar Concentration; Pinacidil; Potassium; Potassium Channels; Pyrrolidines; Sodium Chloride; Vasodilator Agents	1997
Effect of potassium channel openers on the firing rate of hippocampal pyramidal cells and A10 dopaminergic neurons in vitro. Archives of physiology and biochemistry, 1997, Volume: 105, Issue:5 Topics: Action Potentials; Animals; Cromakalim; Diazoxide; Dopamine; Guanidines; Hippocampus; In Vitro Techniques; Male; Neurons; Pinacidil; Potassium Channels; Pyramidal Cells; Pyridines; Rats; Rats, Wistar; Thiadiazines; Ventral Tegmental Area	1997
The effects of nucleotides and potassium channel openers on the SUR2A/Kir6.2 complex K+ channel expressed in a mammalian cell line, HEK293T cells. Pflugers Archiv : European journal of physiology, 1998, Volume: 435, Issue:5 Topics: Adenosine Triphosphate; ATP-Binding Cassette Transporters; Cell Line; Diazoxide; Guanidines; Humans; Membrane Potentials; Niacinamide; Nicorandil; Patch-Clamp Techniques; Pinacidil; Potassium Channels; Potassium Channels, Inwardly Rectifying; Receptors, Drug; Sulfonylurea Receptors; Uridine Diphosphate	1998
Direct effects of diazoxide on mitochondria in pancreatic B-cells and on isolated liver mitochondria. British journal of pharmacology, 1998, Volume: 123, Issue:5 Topics: Adenosine Triphosphate; Animals; Calcium; Calcium Channel Blockers; Cromakalim; Diazoxide; Gallopamil; Guanidines; In Vitro Techniques; Islets of Langerhans; Membrane Potentials; Mice; Mice, Obese; Mitochondria; Mitochondria, Liver; Oxidative Phosphorylation; Pinacidil; Potassium Channels; Rats; Rhodamine 123; Rhodamines	1998
Pyridothiadiazines as potent inhibitors of glucose-induced insulin release. Advances in experimental medicine and biology, 1997, Volume: 426 Topics: Animals; Calcium; Cytosol; Diazoxide; Glucose; Guanidines; In Vitro Techniques; Insulin; Insulin Secretion; Islets of Langerhans; Kinetics; Pinacidil; Pyridines; Rats; Rubidium; Structure-Activity Relationship; Thiadiazines; Time Factors	1997
The effects of potassium channel openers on saphenous vein exposed to arterial flow. European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery, 1998, Volume: 15, Issue:3 Topics: Arteries; Blood Flow Velocity; Chromans; Cromakalim; Diazoxide; Guanidines; Humans; In Vitro Techniques; Phenylephrine; Pinacidil; Potassium Channels; Pyrrolidines; Saphenous Vein; Vasoconstriction; Vasoconstrictor Agents; Vasodilation; Vasodilator Agents	1998
Potassium channel openers require ATP to bind to and act through sulfonylurea receptors. The EMBO journal, 1998, Oct-01, Volume: 17, Issue:19 Topics: Adenosine Triphosphate; Animals; ATP-Binding Cassette Transporters; Binding Sites; Binding, Competitive; Cricetinae; Diazoxide; Glyburide; Guanidines; Humans; Mutation; Peptide Fragments; Pinacidil; Potassium Channels; Potassium Channels, Inwardly Rectifying; Protein Isoforms; Pyridines; Receptors, Drug; Recombinant Proteins; Sulfonylurea Receptors	1998
Reconstituted human cardiac KATP channels: functional identity with the native channels from the sarcolemma of human ventricular cells. Circulation research, 1998, Nov-30, Volume: 83, Issue:11 Topics: Adenosine Diphosphate; Adenosine Triphosphate; Adolescent; Adult; Animals; ATP-Binding Cassette Transporters; Child; CHO Cells; Cloning, Molecular; COS Cells; Cricetinae; Cromakalim; Diazoxide; DNA, Complementary; Gene Library; Glyburide; Heart Ventricles; Humans; Magnesium; Middle Aged; Myocardium; Patch-Clamp Techniques; Pinacidil; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Inwardly Rectifying; Rats; Receptors, Drug; Sarcolemma; Sulfonylurea Receptors; Tolbutamide; Transfection	1998
Antisense oligodeoxynucleotides of sulfonylurea receptors inhibit ATP-sensitive K+ channels in cultured neonatal rat ventricular cells. Pflugers Archiv : European journal of physiology, 1999, Volume: 437, Issue:3 Topics: Adenosine Triphosphate; Animals; Animals, Newborn; ATP-Binding Cassette Transporters; Cells, Cultured; Diazoxide; Electric Conductivity; Heart; Oligodeoxyribonucleotides, Antisense; Pinacidil; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Inwardly Rectifying; Rats; Rats, Sprague-Dawley; Receptors, Drug; Sulfonylurea Receptors; Ventricular Function	1999
Ischemic preconditioning depends on interaction between mitochondrial KATP channels and actin cytoskeleton. The American journal of physiology, 1999, Volume: 276, Issue:4 Topics: Actins; Adenosine Triphosphate; Animals; Anisomycin; Calcium-Calmodulin-Dependent Protein Kinases; Cytochalasin D; Cytoskeleton; Decanoic Acids; Diazoxide; Enzyme Activation; Female; Hydroxy Acids; Ischemic Preconditioning, Myocardial; Male; Mitochondria, Heart; Mitogen-Activated Protein Kinases; Osmotic Fragility; p38 Mitogen-Activated Protein Kinases; Pinacidil; Potassium Channel Blockers; Potassium Channels; Rabbits	1999
Evidence for presence of ATP-sensitive K+ channels in rat colonic smooth muscle cells. Canadian journal of physiology and pharmacology, 1998, Volume: 76, Issue:12 Topics: Adenosine Triphosphate; Animals; Colon; Diazoxide; Muscle, Smooth; Patch-Clamp Techniques; Pinacidil; Potassium Channels; Rats; Rats, Sprague-Dawley; Vasodilator Agents	1998
ATP-sensitive K+ channel openers prevent Ca2+ overload in rat cardiac mitochondria. The Journal of physiology, 1999, Sep-01, Volume: 519 Pt 2 Topics: Adenosine Diphosphate; Adenosine Triphosphate; Animals; Calcium; Cyclosporine; Diazoxide; In Vitro Techniques; Ionophores; Membrane Potentials; Membrane Proteins; Microscopy, Confocal; Mitochondria, Heart; Myocardium; Oxygen Consumption; Permeability; Pinacidil; Potassium Channels; Rats; Rats, Sprague-Dawley; Valinomycin	1999
Troglitazone but not pioglitazone affects ATP-sensitive K(+) channel activity. European journal of pharmacology, 1999, Sep-17, Volume: 381, Issue:1 Topics: Adenosine Triphosphate; Animals; ATP-Binding Cassette Transporters; Chromans; COS Cells; Diazoxide; Electrophysiology; Glyburide; Membrane Potentials; Pinacidil; Pioglitazone; Potassium Channels; Potassium Channels, Inwardly Rectifying; Receptors, Drug; Recombinant Fusion Proteins; Rubidium Radioisotopes; Sulfonylurea Receptors; Thiazoles; Thiazolidinediones; Transfection; Troglitazone	1999
Modulation of norepinephrine release by ATP-dependent K(+)-channel activators and inhibitors in guinea-pig and human isolated right atrium. Cardiovascular research, 1999, Volume: 43, Issue:1 Topics: Adenosine; Adrenergic alpha-1 Receptor Agonists; Adrenergic alpha-2 Receptor Agonists; Analysis of Variance; Animals; Clonidine; Cromakalim; Decanoic Acids; Diazoxide; Dose-Response Relationship, Drug; Glyburide; Guinea Pigs; Heart Atria; Humans; Hydroxy Acids; In Vitro Techniques; Male; Muscarinic Agonists; Norepinephrine; Oxotremorine; Pinacidil; Potassium Channel Blockers; Potassium Channels; Stimulation, Chemical; Sympathetic Nervous System	1999
ATP-sensitive potassium channels and efaroxan-induced insulin release in the electrofusion-derived BRIN-BD11 beta-cell line. Diabetes, 1999, Volume: 48, Issue:12 Topics: Adenosine Diphosphate; Adenosine Triphosphate; Adrenergic alpha-Antagonists; Animals; Benzofurans; Cell Fusion; Cell Line; Diazoxide; Glucose; Imidazoles; Insulin; Insulin Secretion; Insulinoma; Islets of Langerhans; Membrane Potentials; Pancreatic Neoplasms; Phentolamine; Pinacidil; Potassium Channels; Tolbutamide; Tumor Cells, Cultured	1999
Involvement of adenosine triphosphate-sensitive K+ channels in glucose-sensing in the rat solitary tract nucleus. Neuroscience letters, 2000, Jan-07, Volume: 278, Issue:1-2 Topics: Adenosine Triphosphate; Animals; Blood Glucose; Diazoxide; Glyburide; Homeostasis; Hypoglycemia; Hypoglycemic Agents; Male; Nerve Tissue Proteins; Neurons; Pinacidil; Potassium Channels; Rats; Rats, Wistar; Solitary Nucleus; Tolbutamide	2000
Activation of mitochondrial ATP-dependent potassium channels by nitric oxide. Circulation, 2000, Feb-01, Volume: 101, Issue:4 Topics: Animals; Cyclic GMP; Diazoxide; Flavoproteins; Heart Ventricles; Membrane Potentials; Mitochondria, Heart; Nitric Oxide; Nitric Oxide Donors; Oxidation-Reduction; Penicillamine; Pinacidil; Potassium Channels; Rabbits; S-Nitroso-N-Acetylpenicillamine; Sarcolemma	2000
ATP-sensitive potassium channel regulates astrocytic gap junction permeability by a Ca2+-independent mechanism. Journal of neurochemistry, 2000, Volume: 74, Issue:3 Topics: Adenosine Triphosphate; Animals; Astrocytes; Calcium; Cells, Cultured; Diazoxide; Gap Junctions; Intracellular Membranes; Osmolar Concentration; Permeability; Pinacidil; Potassium Channels; Rats; Rats, Wistar; Sulfonylurea Compounds; Uncoupling Agents	2000
Evidence for mitochondrial K ATP channels as effectors of human myocardial preconditioning. Cardiovascular research, 2000, Volume: 45, Issue:4 Topics: Analysis of Variance; Cell Membrane; Decanoic Acids; Diazoxide; Dose-Response Relationship, Drug; Glyburide; Heart; Humans; Hydroxy Acids; Hypoglycemic Agents; In Vitro Techniques; Ischemic Preconditioning, Myocardial; Mitochondria, Heart; Myocardial Ischemia; Pinacidil; Potassium Channel Blockers; Potassium Channels; Random Allocation; Sarcolemma; Sulfonamides; Thiourea	2000
Pharmacology and modulation of K(ATP) channels by protein kinase C and phosphatases in gallbladder smooth muscle. American journal of physiology. Cell physiology, 2000, Volume: 278, Issue:5 Topics: Adenosine Triphosphate; Animals; Diazoxide; Enzyme Activation; Female; Gallbladder; Glyburide; Guinea Pigs; Male; Muscle, Smooth; Muscle, Smooth, Vascular; Okadaic Acid; Phosphoric Monoester Hydrolases; Pinacidil; Potassium Channels; Protein Kinase C; Rats; Rats, Sprague-Dawley	2000
The molecular basis of the specificity of action of K(ATP) channel openers. The EMBO journal, 2000, Dec-15, Volume: 19, Issue:24 Topics: Amino Acid Sequence; Animals; ATP-Binding Cassette Transporters; Cell Membrane; Cricetinae; Cromakalim; Diazoxide; Ion Channel Gating; Mice; Models, Molecular; Molecular Sequence Data; Muscle, Skeletal; Mutagenesis, Site-Directed; Neurons; Nicorandil; Oocytes; Pancreas; Pinacidil; Potassium Channels; Potassium Channels, Inwardly Rectifying; Protein Isoforms; Protein Structure, Secondary; Rats; Receptors, Drug; Recombinant Fusion Proteins; Sulfonylurea Receptors	2000
Bioenergetic consequences of opening the ATP-sensitive K(+) channel of heart mitochondria. American journal of physiology. Heart and circulatory physiology, 2001, Volume: 280, Issue:2 Topics: Adenosine Triphosphate; Animals; Anions; Cell Respiration; Diazoxide; Energy Metabolism; Ion Channel Gating; Membrane Potentials; Mitochondria; Mitochondrial Swelling; Myocardial Reperfusion Injury; Myocardium; Pinacidil; Potassium; Potassium Channels; Rats; Succinic Acid; Uncoupling Agents; Vasodilator Agents	2001
Pharmacological comparison of native mitochondrial K(ATP) channels with molecularly defined surface K(ATP) channels. Molecular pharmacology, 2001, Volume: 59, Issue:2 Topics: Animals; ATP-Binding Cassette Transporters; Cells, Cultured; Diazoxide; Glyburide; Guanidines; Heart Ventricles; Humans; KATP Channels; Membrane Proteins; Mitochondria, Heart; Myocardium; Patch-Clamp Techniques; Pinacidil; Potassium Channels; Potassium Channels, Inwardly Rectifying; Pyridines; Rabbits; Receptors, Drug; Recombinant Proteins; Sulfonylurea Receptors; Vasodilator Agents	2001
Functional roles of cardiac and vascular ATP-sensitive potassium channels clarified by Kir6.2-knockout mice. Circulation research, 2001, Mar-30, Volume: 88, Issue:6 Topics: Adenosine Triphosphate; Adenoviridae; Animals; Aorta; Blood Pressure; Blotting, Northern; Diazoxide; Dose-Response Relationship, Drug; Electrophysiology; Genetic Vectors; Genotype; Glyburide; Heart; Heart Rate; Heart Ventricles; In Vitro Techniques; Membrane Potentials; Mice; Mice, Inbred C57BL; Mice, Knockout; Muscle, Smooth, Vascular; Norepinephrine; Pinacidil; Potassium Channels; Potassium Channels, Inwardly Rectifying; RNA, Messenger; Transfection; Vasoconstriction; Vasodilator Agents; Ventricular Function	2001
Mitochondrial ATP-sensitive potassium channels inhibit apoptosis induced by oxidative stress in cardiac cells. Circulation research, 2001, Jun-22, Volume: 88, Issue:12 Topics: Adenosine Triphosphate; Animals; Apoptosis; Caspase 3; Caspases; Cells, Cultured; Cytochrome c Group; Decanoic Acids; Diazoxide; Dose-Response Relationship, Drug; Flow Cytometry; Fluorescent Dyes; Heart Ventricles; Hydrogen Peroxide; Hydroxy Acids; Image Processing, Computer-Assisted; In Situ Nick-End Labeling; Membrane Potentials; Mitochondria; Myocardium; Oxidative Stress; Pinacidil; Potassium Channel Blockers; Potassium Channels; Protein Transport; Rats; Rats, Sprague-Dawley	2001
Sulfonylurea receptors inhibit the epithelial sodium channel (ENaC) by reducing surface expression. Pflugers Archiv : European journal of physiology, 2001, Volume: 442, Issue:5 Topics: Animals; ATP-Binding Cassette Transporters; Cystic Fibrosis Transmembrane Conductance Regulator; Diazoxide; Diuretics; Epithelial Sodium Channels; Glyburide; Hypoglycemic Agents; Oocytes; Patch-Clamp Techniques; Pinacidil; Potassium Channels; Potassium Channels, Inwardly Rectifying; Receptors, Drug; Sodium Channel Blockers; Sodium Channels; Sodium Chloride Symporter Inhibitors; Sulfonylurea Receptors; Time Factors; Tolbutamide; Vasodilator Agents; Xenopus laevis	2001
Diazoxide and pinacidil uncouple pyruvate-malate-induced mitochondrial respiration. Journal of bioenergetics and biomembranes, 2002, Volume: 34, Issue:1 Topics: Animals; Antihypertensive Agents; Diazoxide; Dose-Response Relationship, Drug; Electron Transport; Kinetics; Malates; Male; Membrane Potentials; Mitochondria, Heart; Mitochondrial ADP, ATP Translocases; Oxygen Consumption; Pinacidil; Pyruvic Acid; Rats; Rats, Wistar; Uncoupling Agents	2002
Effects of K(ATP) channel openers, P-1075, pinacidil, and diazoxide, on energetics and contractile function in isolated rat hearts. Journal of molecular and cellular cardiology, 2002, Volume: 34, Issue:4 Topics: 2,4-Dinitrophenol; Adenosine Triphosphate; Animals; Diazoxide; Guanidines; Heart; In Vitro Techniques; Magnetic Resonance Spectroscopy; Male; Myocardial Contraction; Myocardium; Oxidative Phosphorylation; Oxygen Consumption; Perfusion; Phosphocreatine; Pinacidil; Potassium Channel Blockers; Potassium Channels; Pyridines; Rats; Rats, Sprague-Dawley; Vasodilator Agents	2002
Effects of K(ATP) channel modulators on acetylcholine release from guinea-pig isolated atria and small intestine. Naunyn-Schmiedeberg's archives of pharmacology, 2002, Volume: 365, Issue:5 Topics: Acetylcholine; Animals; Atrial Function; Cromakalim; Diazoxide; Female; Glyburide; Guinea Pigs; Heart Atria; In Vitro Techniques; Intestine, Small; Male; Muscle, Smooth; Myenteric Plexus; Myocardial Contraction; Neuromuscular Junction; Pinacidil; Potassium Channel Blockers; Potassium Channels; Sulfonamides; Thiourea	2002
Mitochondrial K(ATP) channel openers activate the ERK kinase by an oxidant-dependent mechanism. American journal of physiology. Cell physiology, 2002, Volume: 283, Issue:1 Topics: Adenosine Triphosphate; Adenoviridae; Cell Line; Diazoxide; Enzyme Activation; Gene Transfer Techniques; Genetic Vectors; Humans; Intracellular Membranes; Mitochondria; Mitogen-Activated Protein Kinases; Phosphorylation; Pinacidil; Potassium Channels; Reactive Oxygen Species; Superoxide Dismutase	2002
Ketamine abolishes ischemic preconditioning through inhibition of K(ATP) channels in rabbit hearts. American journal of physiology. Heart and circulatory physiology, 2002, Volume: 283, Issue:1 Topics: Animals; Cell Separation; Cytoprotection; Diazoxide; Heart; Hypoxia; In Vitro Techniques; Ischemic Preconditioning, Myocardial; Ketamine; Membrane Potentials; Mitochondria; Myocardium; Patch-Clamp Techniques; Pinacidil; Potassium Channels; Rabbits; Sarcolemma; Vasodilator Agents	2002
K(ATP) channel-independent targets of diazoxide and 5-hydroxydecanoate in the heart. The Journal of physiology, 2002, Aug-01, Volume: 542, Issue:Pt 3 Topics: Acyl Coenzyme A; Adenosine Triphosphate; Animals; Coenzyme A Ligases; Decanoic Acids; Diazoxide; Electron Transport; Flavoproteins; Fluorescence; Guinea Pigs; Heart; Hydroxy Acids; Membrane Potentials; Mitochondria, Heart; Myocardium; Pinacidil; Potassium Channels; Repressor Proteins; Saccharomyces cerevisiae Proteins	2002
Opening of ATP-sensitive potassium channels causes generation of free radicals in vascular smooth muscle cells. Basic research in cardiology, 2002, Volume: 97, Issue:5 Topics: Animals; ATP-Binding Cassette Transporters; Cells, Cultured; Diazoxide; Free Radicals; Ion Channel Gating; KATP Channels; Mitochondria; Muscle, Smooth, Vascular; Pinacidil; Potassium Channels; Potassium Channels, Inwardly Rectifying; Protein Kinase C; Reactive Oxygen Species; Vasodilator Agents	2002
The role of myocardial KATP-channel blockade in the protective effects of glibenclamide against ischaemia in the rat heart. Pharmacology & toxicology, 2002, Volume: 91, Issue:2 Topics: Animals; Coronary Circulation; Diazoxide; Drug Interactions; Glyburide; Male; Myocardial Ischemia; Pinacidil; Potassium Channels; Rats; Rats, Wistar	2002
Modulation of the trafficking efficiency and functional properties of ATP-sensitive potassium channels through a single amino acid in the sulfonylurea receptor. The Journal of biological chemistry, 2003, Feb-28, Volume: 278, Issue:9 Topics: Adenosine Diphosphate; Adenosine Triphosphate; Animals; Anti-Arrhythmia Agents; ATP-Binding Cassette Transporters; Blotting, Western; COS Cells; Cricetinae; Diazoxide; Dose-Response Relationship, Drug; Glyburide; Immunoblotting; Luminescent Measurements; Magnesium; Mice; Mutation; Patch-Clamp Techniques; Pinacidil; Potassium; Potassium Channels; Potassium Channels, Inwardly Rectifying; Protein Isoforms; Protein Structure, Tertiary; Protein Transport; Rats; Receptors, Drug; Rubidium; Sulfonylurea Receptors; Time Factors; Transfection; Vasodilator Agents	2003
Synthesis and biological activity of 3,3-diamino-sulfonylacrylonitriles as novel inhibitors of glucose induced insulin secretion from beta cells. Bioorganic & medicinal chemistry, 2003, Mar-20, Volume: 11, Issue:6 Topics: Acrylonitrile; Animals; Crystallography, X-Ray; Diazoxide; Diuretics; Female; Glucose; Hydrogen Bonding; In Vitro Techniques; Indicators and Reagents; Insulin; Insulin Secretion; Islets of Langerhans; Magnetic Resonance Spectroscopy; Models, Molecular; Molecular Conformation; Muscle Relaxation; Muscle, Smooth, Vascular; Pinacidil; Rats; Rats, Wistar; Sodium Chloride Symporter Inhibitors	2003
ATP-sensitive potassium channels in rat primary afferent neurons: the effect of neuropathic injury and gabapentin. Neuroscience letters, 2003, Jun-12, Volume: 343, Issue:3 Topics: Acetates; Amines; Animals; ATP-Binding Cassette Transporters; Basal Ganglia; Cyclohexanecarboxylic Acids; Diazoxide; Excitatory Amino Acid Antagonists; Gabapentin; gamma-Aminobutyric Acid; Ganglia, Spinal; Glyburide; KATP Channels; Male; Neurons, Afferent; Neuroprotective Agents; Pain; Peripheral Nervous System Diseases; Pinacidil; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Inwardly Rectifying; Rats; Rats, Sprague-Dawley	2003
Effect of high concentration of glucose on dopamine release from pheochromocytoma-12 cells. Metabolism: clinical and experimental, 2003, Volume: 52, Issue:7 Topics: Adenosine Triphosphate; Animals; Calcium; Calcium Channel Blockers; Calcium Channels; Calcium Radioisotopes; Diazoxide; Dopamine; Dose-Response Relationship, Drug; Glucose; Ion Channel Gating; Membrane Potentials; Mice; Neurons; Nicardipine; PC12 Cells; Pinacidil; Potassium Channels; Potassium Chloride; Rats	2003
Adenine nucleotide translocase mediates the K(ATP)-channel-openers-induced proton and potassium flux to the mitochondrial matrix. Journal of bioenergetics and biomembranes, 2003, Volume: 35, Issue:2 Topics: Animals; Atractyloside; Bongkrekic Acid; Cells, Cultured; Diazoxide; Dose-Response Relationship, Drug; Extracellular Matrix; Ion Channel Gating; Membrane Potentials; Membrane Proteins; Mitochondria, Heart; Mitochondrial ADP, ATP Translocases; Pinacidil; Potassium; Potassium Channels; Proton Pumps; Rats; Rats, Wistar	2003
Molecular mechanisms of the inhibitory effects of propofol and thiamylal on sarcolemmal adenosine triphosphate-sensitive potassium channels. Anesthesiology, 2004, Volume: 100, Issue:2 Topics: Anesthetics, Intravenous; Animals; ATP-Binding Cassette Transporters; Cells, Cultured; Diazoxide; Electrophysiology; Glyburide; Humans; Molecular Biology; Patch-Clamp Techniques; Pinacidil; Potassium Channels; Potassium Channels, Inwardly Rectifying; Propofol; Rats; Receptors, Drug; Sulfonylurea Receptors; Thiamylal; Vasodilator Agents	2004
Potassium channel openers are uncoupling protonophores: implication in cardioprotection. FEBS letters, 2004, Jun-18, Volume: 568, Issue:1-3 Topics: Animals; Cardiotonic Agents; Diazoxide; Mitochondria, Heart; Oxidative Phosphorylation; Pinacidil; Potassium Channels; Rats; Uncoupling Agents	2004
Testosterone induces cytoprotection by activating ATP-sensitive K+ channels in the cardiac mitochondrial inner membrane. Circulation, 2004, Nov-09, Volume: 110, Issue:19 Topics: Adenosine Triphosphate; Androgen Receptor Antagonists; Androstenedione; Animals; Biological Transport, Active; Cells, Cultured; Diazoxide; Flutamide; G Protein-Coupled Inwardly-Rectifying Potassium Channels; Ion Transport; Male; Membrane Proteins; Mitochondria, Heart; Mitochondrial Membrane Transport Proteins; Myocardial Ischemia; Myocytes, Cardiac; Patch-Clamp Techniques; Pinacidil; Potassium; Potassium Channels; Potassium Channels, Inwardly Rectifying; Rats; Rats, Sprague-Dawley; Sarcoplasmic Reticulum; Testosterone	2004
150-kD oxygen-regulated protein is an essential factor for insulin release. Pancreas, 2005, Volume: 30, Issue:4 Topics: Adenoviridae; Animals; Antisense Elements (Genetics); Cell Line, Tumor; Cromakalim; Diazoxide; Genes, Reporter; Glucose; HSP70 Heat-Shock Proteins; Insulin; Insulin Secretion; Insulin-Secreting Cells; Insulinoma; Mice; Pinacidil; Potassium Channels; Proteins; Vasodilator Agents	2005
Selective inhibition of pinacidil effects by estrogen in guinea pig heart. International journal of cardiology, 2006, Jun-07, Volume: 110, Issue:1 Topics: Animals; Bronchodilator Agents; Chromans; Diazoxide; Down-Regulation; Estradiol; Estrogen Antagonists; Estrogens; Female; Guinea Pigs; Heart Atria; Heart Rate; L-Lactate Dehydrogenase; Male; Pinacidil; Potassium Channels; Pyrrolidines; Receptors, Estrogen; Tamoxifen; Vasodilator Agents	2006
Initiation of remote microvascular preconditioning requires K(ATP) channel activity. American journal of physiology. Heart and circulatory physiology, 2006, Volume: 290, Issue:1 Topics: Adenosine; Animals; Arginine; Arterioles; ATP-Binding Cassette Transporters; Bradykinin; Cricetinae; Cyclic GMP; Decanoic Acids; Diazoxide; Hydroxy Acids; Ischemic Preconditioning; KATP Channels; Male; Mesocricetus; Microcirculation; Nitric Oxide Donors; Nitroprusside; Pinacidil; Potassium Channels, Inwardly Rectifying; Signal Transduction; Vasodilation	2006
KATP channels in mouse spermatogenic cells and sperm, and their role in capacitation. Developmental biology, 2006, Jan-15, Volume: 289, Issue:2 Topics: Adenosine Triphosphate; Animals; ATP-Binding Cassette Transporters; Barium; Diazoxide; Dose-Response Relationship, Drug; Glyburide; KATP Channels; Male; Membrane Potentials; Mice; Microscopy, Confocal; Multidrug Resistance-Associated Proteins; Pinacidil; Potassium Channels, Inwardly Rectifying; Receptors, Drug; RNA, Messenger; Sperm Capacitation; Spermatogenesis; Spermatozoa; Sulfonylurea Receptors; Time Factors; Tolbutamide	2006
[Effects of iptakalim on intracellular calcium concentrations, PKA and PKC activities in rat tail artery smooth muscle cells]. Yao xue xue bao = Acta pharmaceutica Sinica, 2005, Volume: 40, Issue:10 Topics: Animals; Antihypertensive Agents; Calcium; Cells, Cultured; Cyclic AMP-Dependent Protein Kinases; Diazoxide; Male; Muscle, Smooth, Vascular; Pinacidil; Propylamines; Protein Kinase C; Rats; Rats, Sprague-Dawley; Tail	2005
The nitric oxide-cyclic GMP-protein kinase G-K+ channel pathway participates in the antiallodynic effect of spinal gabapentin. European journal of pharmacology, 2006, Feb-15, Volume: 531, Issue:1-3 Topics: Amines; Analgesics; Animals; Apamin; Carbazoles; Charybdotoxin; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Cyclohexanecarboxylic Acids; Diazoxide; Dose-Response Relationship, Drug; Enzyme Inhibitors; Female; Gabapentin; gamma-Aminobutyric Acid; Glyburide; Indazoles; Indoles; Injections, Spinal; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Okadaic Acid; Oxadiazoles; Pain; Pinacidil; Potassium Channel Blockers; Potassium Channels; Protein Kinase Inhibitors; Quinoxalines; Rats; Rats, Wistar; Signal Transduction; Spinal Nerves; Stereoisomerism; Time Factors; Vasodilator Agents	2006
Actions of ZD0947, a novel ATP-sensitive K+ channel opener, on membrane currents in human detrusor myocytes. British journal of pharmacology, 2006, Volume: 149, Issue:5 Topics: ATP-Binding Cassette Transporters; Carbachol; Diazoxide; Dihydropyridines; Dose-Response Relationship, Drug; G Protein-Coupled Inwardly-Rectifying Potassium Channels; Gliclazide; Glyburide; Humans; Immunochemistry; In Vitro Techniques; Membrane Potentials; Muscle Relaxation; Myocytes, Smooth Muscle; Patch-Clamp Techniques; Pinacidil; Potassium Channels; Potassium Channels, Inwardly Rectifying; Receptors, Drug; Sulfonylurea Receptors; Urinary Bladder	2006
Identification of two types of ATP-sensitive K+ channels in rat ventricular myocytes. Life sciences, 2007, Jan-02, Volume: 80, Issue:4 Topics: Animals; Blotting, Western; Calcium; Diazoxide; Dinitrophenols; Dose-Response Relationship, Drug; Fluorescent Antibody Technique, Direct; Gene Expression; Glyburide; Heart Ventricles; KATP Channels; Male; Membrane Potentials; Myocytes, Cardiac; Patch-Clamp Techniques; Pinacidil; Potassium Channels, Inwardly Rectifying; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger	2007
ATP-sensitive potassium channel: a novel target for protection against UV-induced human skin cell damage. Journal of cellular physiology, 2007, Volume: 212, Issue:1 Topics: Adenosine Triphosphate; Diazoxide; Dose-Response Relationship, Drug; Dose-Response Relationship, Radiation; Humans; Keratinocytes; Membrane Potential, Mitochondrial; Pinacidil; Potassium Channels, Inwardly Rectifying; Reactive Oxygen Species; Time Factors; Ultraviolet Rays; Vasodilator Agents	2007
KATP channel openers have opposite effects on mitochondrial respiration under different energetic conditions. Journal of cardiovascular pharmacology, 2008, Volume: 51, Issue:5 Topics: Animals; Decanoic Acids; Diazoxide; Electron Transport Complex I; Electron Transport Complex II; Glyburide; Guinea Pigs; Hydroxy Acids; In Vitro Techniques; Mitochondria, Heart; Mitochondrial Proton-Translocating ATPases; Oxygen Consumption; Pinacidil; Potassium Channel Blockers; Potassium Channels	2008
Sulfonylurea receptor-dependent and -independent pathways mediate vasodilation induced by ATP-sensitive K+ channel openers. Molecular pharmacology, 2008, Volume: 74, Issue:3 Topics: Adenosine Triphosphate; Animals; ATP-Binding Cassette Transporters; Blood Pressure; Diazoxide; Electron Transport Complex II; Endothelium; In Vitro Techniques; Ion Channel Gating; Membrane Transport Modulators; Mesenteric Arteries; Mice; Muscle Cells; Pinacidil; Potassium Channels; Potassium Channels, Inwardly Rectifying; Protein Subunits; Receptors, Drug; Ryanodine Receptor Calcium Release Channel; Sulfonylurea Receptors; Vasodilation	2008
The phenomenon of seasonal pseudohypokalemia: effects of ambient temperature, plasma glucose and role for sodium-potassium-exchanging-ATPase. Clinical biochemistry, 2009, Volume: 42, Issue:9 Topics: Blood Glucose; Diazoxide; Enzyme Activation; Humans; Hypokalemia; Membrane Transport Modulators; Pinacidil; Potassium; Sodium-Potassium-Exchanging ATPase; Temperature; Tolbutamide	2009
[Effect of adenosine triphosphate-dependent potassium channel activators on electrical reactions of intact and cultured endothelial cells]. Fiziolohichnyi zhurnal (Kiev, Ukraine : 1994), 2009, Volume: 55, Issue:1 Topics: Animals; Cells, Cultured; Diazoxide; Endothelial Cells; Endothelium, Vascular; Humans; Ion Channel Gating; KATP Channels; Membrane Potentials; Pinacidil; Rats	2009
Differential K(ATP) channel pharmacology in intact mouse heart. Journal of molecular and cellular cardiology, 2010, Volume: 48, Issue:1 Topics: Action Potentials; Animals; ATP-Binding Cassette Transporters; Diazoxide; Glyburide; Heart; In Vitro Techniques; KATP Channels; Mice; Mice, Knockout; Microscopy; Myocardium; Pinacidil; Potassium Channels, Inwardly Rectifying; Receptors, Drug; Sulfonylurea Receptors; Vasodilator Agents	2010
K(ATP) channel openers protect mesencephalic neurons against MPP+-induced cytotoxicity via inhibition of ROS production. Journal of neuroscience research, 2010, Feb-01, Volume: 88, Issue:2 Topics: 1-Methyl-4-phenylpyridinium; Animals; Cells, Cultured; Cromakalim; Cytochromes c; Diazoxide; Dopamine; KATP Channels; Membrane Transport Modulators; Mesencephalon; Mice; Mice, Inbred C57BL; Mitochondria; Neurons; Neuroprotective Agents; Neurotoxins; Oxidative Stress; Pinacidil; Potassium Channels, Inwardly Rectifying; Reactive Oxygen Species	2010
Inhibition of oxygen consumption in skeletal muscle-derived mitochondria by pinacidil, diazoxide, and glibenclamide, but not by 5-hydroxydecanoate. Journal of bioenergetics and biomembranes, 2010, Volume: 42, Issue:1 Topics: Animals; Chickens; Decanoic Acids; Diazoxide; Glyburide; Hydroxy Acids; In Vitro Techniques; Mitochondria, Muscle; Muscle, Skeletal; Oxygen Consumption; Pinacidil; Potassium Channel Blockers; Potassium Channels	2010
Direct effects of K(ATP) channel openers pinacidil and diazoxide on oxidative phosphorylation of mitochondria in situ. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 2010, Volume: 25, Issue:2-3 Topics: Animals; Diazoxide; KATP Channels; Malates; Male; Mitochondria, Heart; Myocardium; Oxidative Phosphorylation; Pinacidil; Pyruvic Acid; Rats; Rats, Wistar; Respiratory Rate; Vasodilator Agents	2010
Pharmacological stimulation and inhibition of insulin secretion in mouse islets lacking ATP-sensitive K+ channels. British journal of pharmacology, 2010, Feb-01, Volume: 159, Issue:3 Topics: Animals; Benzofurans; Calcium; Cytosol; Diazoxide; Female; Imidazoles; Imidazolines; Insulin; Insulin Secretion; Insulin-Secreting Cells; KATP Channels; Mice; Mice, Knockout; Phentolamine; Pinacidil; Potassium Channels; Tolbutamide	2010
A study of the relationship between pharmacologic preconditioning and adenosine triphosphate-sensitive potassium (KATP) channels on cultured cardiomyocytes using the microelectrode array. Journal of cardiovascular pharmacology, 2010, Volume: 56, Issue:1 Topics: Animals; Cell Survival; Cells, Cultured; Connexin 43; Diazoxide; Electrophysiology; Gene Expression Regulation; Ischemic Preconditioning, Myocardial; KATP Channels; Microelectrodes; Myocytes, Cardiac; Pinacidil; Potassium Channels; Rats; Rats, Sprague-Dawley; Vasodilator Agents	2010
Both mitochondrial KATP channel opening and sarcolemmal KATP channel blockage confer protection against ischemia/reperfusion-induced arrhythmia in anesthetized male rats. Journal of cardiovascular pharmacology and therapeutics, 2010, Volume: 15, Issue:4 Topics: Animals; Anti-Arrhythmia Agents; Antihypertensive Agents; Arrhythmias, Cardiac; Benzamides; Diazoxide; Female; KATP Channels; Male; Myocardial Reperfusion Injury; Pinacidil; Potassium Channel Blockers; Potassium Channels; Rats; Rats, Sprague-Dawley; Sarcolemma; Sex Characteristics	2010
Diazoxide maintenance of myocyte volume and contractility during stress: evidence for a non-sarcolemmal K(ATP) channel location. The Journal of thoracic and cardiovascular surgery, 2010, Volume: 140, Issue:5 Topics: Animals; ATP-Binding Cassette Transporters; Cardioplegic Solutions; Cardiotonic Agents; Cell Size; Diazoxide; Female; Homeostasis; Hyperkalemia; KATP Channels; Male; Membrane Potentials; Mice; Mice, Knockout; Myocardial Contraction; Myocytes, Cardiac; Osmotic Pressure; Patch-Clamp Techniques; Pinacidil; Potassium Channels, Inwardly Rectifying; Receptors, Drug; Sarcolemma; Sulfonylurea Receptors	2010
HMR 1098 is not an SUR isotype specific inhibitor of heterologous or sarcolemmal K ATP channels. Journal of molecular and cellular cardiology, 2011, Volume: 50, Issue:3 Topics: Adenosine Diphosphate; Adenosine Triphosphate; Animals; ATP-Binding Cassette Transporters; Benzamides; Blood Glucose; Diazoxide; Insulin; Islets of Langerhans; KATP Channels; Mice; Mice, Inbred C57BL; Myocytes, Cardiac; Pinacidil; Potassium Channels, Inwardly Rectifying; Receptors, Drug; Sarcolemma; Substrate Specificity; Sulfonylurea Receptors	2011
Ontogeny of sulfonylurea-binding regulatory subunits of K(ATP) channels in the pregnant rat myometrium. Reproduction (Cambridge, England), 2011, Volume: 142, Issue:1 Topics: Animals; ATP-Binding Cassette Transporters; Diazoxide; Female; Gene Expression Regulation; In Vitro Techniques; KATP Channels; Myometrium; Oxytocin; Pinacidil; Potassium Channel Blockers; Potassium Channels, Inwardly Rectifying; Pregnancy; Pregnancy Proteins; Protein Isoforms; Protein Subunits; Rats; Rats, Sprague-Dawley; Receptors, Drug; RNA, Messenger; Sulfonylurea Compounds; Sulfonylurea Receptors; Tocolytic Agents; Uterine Contraction	2011
Activation of ATP-sensitive potassium channels antagonize nociceptive behavior and hyperexcitability of DRG neurons from rats. Molecular pain, 2011, May-14, Volume: 7 Topics: Animals; Behavior, Animal; Bradykinin; Diazoxide; Ganglia, Spinal; Glyburide; Ion Channel Gating; KATP Channels; Male; Membrane Potentials; Nociceptors; Pain; Physical Stimulation; Pinacidil; Rats; Rats, Sprague-Dawley; Temperature	2011
Effects of KATP channel openers diazoxide and pinacidil in coronary-perfused atria and ventricles from failing and non-failing human hearts. Journal of molecular and cellular cardiology, 2011, Volume: 51, Issue:2 Topics: Action Potentials; Adolescent; Adult; Arrhythmias, Cardiac; Coronary Vessels; Diazoxide; Female; Gene Expression Regulation; Heart Atria; Heart Failure; Heart Ventricles; Humans; KATP Channels; Male; Middle Aged; Myocardial Ischemia; Pinacidil; RNA, Messenger; Vasodilator Agents; Young Adult	2011
Modulation of the 6-position of benzopyran derivatives and inhibitory effects on the insulin releasing process. Bioorganic & medicinal chemistry, 2011, Jul-01, Volume: 19, Issue:13 Topics: Animals; Aorta; Benzopyrans; Cromakalim; Diazoxide; Insulin; Insulin Secretion; Insulin-Secreting Cells; KATP Channels; Pinacidil; Rats; Structure-Activity Relationship; Vasodilator Agents	2011
[Ontogeny of sulphonylurea-binding regulatory subunits of K(ATP) channels in the pregnant rat myometrium]. Acta pharmaceutica Hungarica, 2011, Volume: 81, Issue:3 Topics: Animals; ATP-Binding Cassette Transporters; Blotting, Western; Diazoxide; Female; Gene Expression Regulation; Glyburide; KATP Channels; Myometrium; Oxytocin; Pinacidil; Potassium Channel Blockers; Potassium Channels, Inwardly Rectifying; Pregnancy; Protein Isoforms; Protein Subunits; Rats; Rats, Sprague-Dawley; Receptors, Drug; RNA, Messenger; Sulfonylurea Compounds; Sulfonylurea Receptors; Tocolytic Agents; Uterine Contraction	2011
NMR and fluorescence studies of drug binding to the first nucleotide binding domain of SUR2A. Biochemistry, 2012, Nov-13, Volume: 51, Issue:45 Topics: Adenosine Triphosphate; Animals; ATP-Binding Cassette Transporters; Binding Sites; Diazoxide; Nuclear Magnetic Resonance, Biomolecular; Nucleotides; Pinacidil; Potassium Channels, Inwardly Rectifying; Protein Structure, Tertiary; Rats; Receptors, Drug; Sulfonylurea Receptors	2012
Heterogeneity and function of K(ATP) channels in canine hearts. Heart rhythm, 2013, Volume: 10, Issue:10 Topics: Action Potentials; Animals; Cell Culture Techniques; Diazoxide; Dogs; Heart Atria; Heart Ventricles; KATP Channels; Membrane Transport Modulators; Myocytes, Cardiac; Patch-Clamp Techniques; Pinacidil; Vasodilator Agents	2013
Cardiac chamber ATP-sensitive potassium channel subtype heterogeneity: another mouse trap. Heart rhythm, 2013, Volume: 10, Issue:10 Topics: Animals; Diazoxide; KATP Channels; Membrane Transport Modulators; Myocytes, Cardiac; Pinacidil; Vasodilator Agents	2013
Potassium channel openers increase aortic elastic fiber formation and reverse the genetically determined elastin deficit in the BN rat. Hypertension (Dallas, Tex. : 1979), 2013, Volume: 62, Issue:4 Topics: Animals; Antihypertensive Agents; Aorta; Blood Pressure; Diazoxide; Elastic Tissue; Elastin; Glyburide; Male; Minoxidil; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Pinacidil; Potassium Channels; Rats; Rats, Inbred BN; Vasodilator Agents	2013
Early opening of sarcolemmal ATP-sensitive potassium channels is not a key step in PKC-mediated cardioprotection. Journal of molecular and cellular cardiology, 2015, Volume: 79 Topics: Action Potentials; Adenosine; Animals; Cardiotonic Agents; Cell Separation; Diazoxide; Enzyme Activation; Heart Failure; Ion Channel Gating; Ischemic Preconditioning, Myocardial; Isoenzymes; KATP Channels; Male; Myocardial Contraction; Myocardial Reperfusion; Myocytes, Cardiac; Phenotype; Pinacidil; Protein Kinase C-epsilon; Protein Kinase Inhibitors; Rats, Wistar; Sarcolemma; Tetradecanoylphorbol Acetate; Time Factors	2015
Closure of mitochondrial potassium channels favors opening of the Tl(+)-induced permeability transition pore in Ca(2+)-loaded rat liver mitochondria. Journal of bioenergetics and biomembranes, 2015, Volume: 47, Issue:3 Topics: Animals; Calcium; Cell Respiration; Decanoic Acids; Diazoxide; Hydroxy Acids; Liver; Membrane Potential, Mitochondrial; Mitochondria; Mitochondrial Membrane Transport Proteins; Mitochondrial Permeability Transition Pore; Mitochondrial Swelling; Oxygen Consumption; Pinacidil; Potassium Channel Blockers; Potassium Channels; Rats; Thallium	2015
Isosteviol Sensitizes sarcKATP Channels towards Pinacidil and Potentiates Mitochondrial Uncoupling of Diazoxide in Guinea Pig Ventricular Myocytes. Oxidative medicine and cellular longevity, 2016, Volume: 2016 Topics: Acetylcysteine; Action Potentials; Animals; Calcium Channels, L-Type; Diazoxide; Diterpenes, Kaurane; Flavoproteins; Fluorescence; Glyburide; Guinea Pigs; Heart Ventricles; Ion Channel Gating; KATP Channels; Mitochondria; Myocytes, Cardiac; Oxidation-Reduction; Pinacidil; Reactive Oxygen Species; Sarcolemma; Time Factors	2016
In vitro effect of nicorandil on the carbachol-induced contraction of the lower esophageal sphincter of the rat. Journal of pharmacological sciences, 2016, Volume: 131, Issue:4 Topics: Animals; Carbachol; Diazoxide; Dose-Response Relationship, Drug; Esophageal Sphincter, Lower; Glyburide; In Vitro Techniques; KATP Channels; Muscle Contraction; NG-Nitroarginine Methyl Ester; Nicorandil; Oxadiazoles; Peptides; Pinacidil; Potassium; Quinoxalines; Rats	2016
The Opening of ATP-Sensitive K+ Channels Protects H9c2 Cardiac Cells Against the High Glucose-Induced Injury and Inflammation by Inhibiting the ROS-TLR4-Necroptosis Pathway. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 2017, Volume: 41, Issue:3 Topics: Acetylcysteine; Animals; Apoptosis; Cell Line; Decanoic Acids; Diazoxide; Gene Expression Regulation; Glucose; Glyburide; Hydroxy Acids; Imidazoles; Indoles; Membrane Potential, Mitochondrial; Myocytes, Cardiac; Necrosis; Oxidative Stress; Pinacidil; Potassium Channels; Rats; Reactive Oxygen Species; Receptor-Interacting Protein Serine-Threonine Kinases; Signal Transduction; Sulfonamides; Toll-Like Receptor 4	2017