Page last updated: 2024-08-22

pimozide and thioridazine

pimozide has been researched along with thioridazine in 65 studies

Research

Studies (65)

TimeframeStudies, this research(%)All Research%
pre-199035 (53.85)18.7374
1990's6 (9.23)18.2507
2000's17 (26.15)29.6817
2010's7 (10.77)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Ellefson, CR; Kehr, JR; Miller, A; Woo, CM1
Andrews, PR; Craik, DJ; Martin, JL1
Butler, DE; DeWald, HA; Wise, LD1
Choudhary, MS; Craigo, SC; Meltzer, HY; Monsma, FJ; Roth, BL; Shen, Y; Sibley, DR; Uluer, A1
Audinot, V; Chaput, C; Conte, C; Gavaudan, S; Millan, MJ; Newman-Tancredi, A; Touzard, M; Verrièle, L1
Ikeda, K; Kobayashi, T; Kumanishi, T1
Topliss, JG; Yoshida, F1
Chen, XL; Kang, J; Kongsamut, S; Rampe, D; Roehr, J1
Cavalli, A; De Ponti, F; Poluzzi, E; Recanatini, M1
Ernsberger, P; Hufeisen, SJ; Jayathilake, K; Kroeze, WK; Meltzer, HY; Popadak, BA; Renock, SM; Roth, BL; Steinberg, S1
Pearlstein, R; Rampe, D; Vaz, R1
Glennon, RA1
Keserü, GM1
Li, J; Rajamani, R; Reynolds, CH; Tounge, BA1
Nagashima, R; Nishikawa, T; Tobita, M1
Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL1
Hohlweg, R; Jeppesen, CB; Lau, JF; Rimvall, K1
Bleich, S; Gulbins, E; Kornhuber, J; Reichel, M; Terfloth, L; Tripal, P; Wiltfang, J1
Jia, L; Sun, H1
Caron, G; Ermondi, G; Visentin, S1
Giordanetto, F; Leach, AG; Zachariae, U1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A1
Sen, S; Sinha, N1
Cooper, J; Cui, Y; Fink, M; Gavaghan, DJ; Heath, BM; McMahon, NC; Mirams, GR; Noble, D; Sher, A1
Freiwald, S; Jiang, Y; Jones, JP; Kaspera, R; Katayama, J; Lee, CA; Smith, E; Totah, RA; Walker, GS1
Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ1
Brown, AM; Bruening-Wright, A; Kramer, J; Kuryshev, YA; Myatt, G; Obejero-Paz, CA; Verducci, JS1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K1
Ahlenius, S; Engel, J1
Cuparencu, F; Feszt, G; Kun, I; Orbán, I1
Setler, P; Weidley, E; Zarevics, P1
Fogelholm, R; Kotilainen, P; Lamberg, BA; Linnoila, M; Olkinuora, M; Saarinen, P1
Calne, DB; Claveria, LE; Haskayne, L; Lodge-Patch, IC; Pallis, CA; Petrie, A; Teychenne, PF1
Obukhov, GA1
Martin, IC1
Costa, E; Guidotti, A; Revuelta, A; Zivkovic, B1
Dingell, JV; Hill, H; Robinson, SE; Setler, P; Stawarz, RJ; Sulser, F1
Lechin, F; Van Der Dijs, B1
Costall, B; Naylor, RJ2
Fielding, S; Lal, H; Marky, M1
Clark, ML; Costiloe, JP; Hill, D; Huber, WK; Wood, F1
Kelly, PH; Miller, RJ1
Fillmore, MT; Ruggles, JL; Taukulis, HK1
Peterson, VA; Strobl, JS1
Kirkwood, KL; Lantz, TK; Lewine, MA; Peterson, VA; Strobl, JS; Worley, JF1
Jepsen, SA; Nielsen, EB1
Muscat, R; Towell, A; Willner, P1
Barnes, TR; Katona, CL1
Koga, I; Nishikawa, T; Tanaka, M; Tsuda, A; Uchida, Y1
Castro, JA; de Fenos, OM; de Ferreyra, EC1
Monteiro, LM1
Hiley, CR; Miller, RJ1
Clemens, JA; Sawyer, BD; Smalstig, EB1
Matthysse, S1
Angrist, B; Gershon, S1
Gershon, S; Klingenstein, RJ; Wallach, MB1
Bartholini, G; Keller, HH; Pletscher, A1
Angrist, B; Gershon, S; Rotrosen, J; Wallach, MB1
Alloway, KD; Bashore, TR; Gelman, J; Rebec, GV1
Luchins, DJ; Oliver, AP; Wyatt, RJ1
MacDonald, C; Robertson, A1
Smythies, JR1
Bonaventura, S; Crews, WD; Hay, CL; Rowe, FB; Steele, WK1
Abe, J; Hamada, Y; Harada, T; Hashimoto, K; Horii, I; Sawada, Y; Shiotani, M1

Reviews

4 review(s) available for pimozide and thioridazine

ArticleYear
Understanding the structure-activity relationship of the human ether-a-go-go-related gene cardiac K+ channel. A model for bad behavior.
    Journal of medicinal chemistry, 2003, May-22, Volume: 46, Issue:11

    Topics: Cation Transport Proteins; DNA-Binding Proteins; Drug-Related Side Effects and Adverse Reactions; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Humans; Long QT Syndrome; Models, Molecular; Pharmaceutical Preparations; Potassium Channels; Potassium Channels, Voltage-Gated; Structure-Activity Relationship; Torsades de Pointes; Trans-Activators; Transcriptional Regulator ERG

2003
Higher-end serotonin receptors: 5-HT(5), 5-HT(6), and 5-HT(7).
    Journal of medicinal chemistry, 2003, Jul-03, Volume: 46, Issue:14

    Topics: Animals; Humans; Ligands; Receptors, Serotonin; Serotonin Agents; Serotonin Antagonists; Serotonin Receptor Agonists

2003
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
    Drug discovery today, 2016, Volume: 21, Issue:4

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk

2016
Dopamine and psychotic states: preliminary remarks.
    Advances in biochemical psychopharmacology, 1974, Volume: 12, Issue:0

    Topics: Amphetamine; Animals; Apomorphine; Behavior, Animal; Carbon Radioisotopes; Cats; Cocaine; Dihydroxyphenylalanine; Dopamine; Homovanillic Acid; Humans; Methylphenidate; Pemoline; Phenmetrazine; Pimozide; Psychoses, Substance-Induced; Psychotic Disorders; Rats; Receptors, Cell Surface; Species Specificity; Stereotyped Behavior; Thioridazine; Tyrosine

1974

Trials

4 trial(s) available for pimozide and thioridazine

ArticleYear
Tardive dyskinesia treated with pimozide.
    Journal of the neurological sciences, 1975, Volume: 24, Issue:4

    Topics: Aged; Antipsychotic Agents; Bipolar Disorder; Chlorpromazine; Clinical Trials as Topic; Consciousness Disorders; Drug Therapy, Combination; Female; Fluphenazine; Humans; Male; Middle Aged; Movement Disorders; Parkinson Disease, Secondary; Perphenazine; Phenothiazines; Pimozide; Prochlorperazine; Promazine; Promethazine; Schizophrenia; Thioridazine

1975
Implications of phenothiazine side effects: a study of antiparkinsonian agents in an older population.
    Acta psychiatrica Scandinavica, 1975, Volume: 51, Issue:2

    Topics: Adult; Aged; Antipsychotic Agents; Chlorpromazine; Clinical Trials as Topic; Delayed-Action Preparations; Female; Fluphenazine; Haloperidol; Humans; Long-Term Care; Male; Middle Aged; Parkinson Disease; Parkinson Disease, Secondary; Pimozide; Placebos; Schizophrenia; Thioridazine; Trifluoperazine; Trifluperidol

1975
Pimozide in chronic schizophrenic outpatients.
    Diseases of the nervous system, 1975, Volume: 36, Issue:3

    Topics: Adult; Ambulatory Care; Basal Ganglia Diseases; Chronic Disease; Consciousness Disorders; Drug Evaluation; Headache; Humans; Male; Middle Aged; Movement Disorders; Outpatient Clinics, Hospital; Pimozide; Placebos; Psychiatric Status Rating Scales; Schizophrenia; Social Adjustment; Thioridazine

1975
Prophylactic effects of neuroleptics in symptom-free schizophrenics: roles of dopaminergic and noradrenergic blockers.
    Biological psychiatry, 1985, Volume: 20, Issue:11

    Topics: Adult; Clinical Trials as Topic; Drug Therapy, Combination; Female; Humans; Male; Middle Aged; Pimozide; Prolactin; Schizophrenia; Thioridazine

1985

Other Studies

57 other study(ies) available for pimozide and thioridazine

ArticleYear
Synthesis and biological evaluation of some 2-amino-4-aryl-3H-1,5-benzodiazepine analogues of clozapine.
    Journal of medicinal chemistry, 1978, Volume: 21, Issue:9

    Topics: Adenylyl Cyclase Inhibitors; Animals; Antipsychotic Agents; Avoidance Learning; Brain; Clozapine; Corpus Striatum; Dextroamphetamine; Dibenzazepines; Dopamine; Dose-Response Relationship, Drug; In Vitro Techniques; Male; Mice; Rats

1978
Functional group contributions to drug-receptor interactions.
    Journal of medicinal chemistry, 1984, Volume: 27, Issue:12

    Topics: Animals; Calorimetry; Kinetics; Models, Biological; Protein Binding; Receptors, Cell Surface; Receptors, Drug; Structure-Activity Relationship

1984
(1,3-Dialkyl-5-amino-1H-pyrazol-4-yl)arylmethanones. A series of novel central nervous system depressants.
    Journal of medicinal chemistry, 1984, Volume: 27, Issue:11

    Topics: Animals; Anticonvulsants; Central Nervous System Depressants; Ketones; Male; Mice; Motor Activity; Posture; Pyrazoles; Structure-Activity Relationship

1984
Binding of typical and atypical antipsychotic agents to 5-hydroxytryptamine-6 and 5-hydroxytryptamine-7 receptors.
    The Journal of pharmacology and experimental therapeutics, 1994, Volume: 268, Issue:3

    Topics: Animals; Antipsychotic Agents; Cell Line; Molecular Structure; Rats; Receptors, Serotonin

1994
Agonist and antagonist actions of antipsychotic agents at 5-HT1A receptors: a [35S]GTPgammaS binding study.
    European journal of pharmacology, 1998, Aug-21, Volume: 355, Issue:2-3

    Topics: Animals; Antipsychotic Agents; CHO Cells; Cricetinae; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Serotonin Agents; Sulfur Radioisotopes

1998
Inhibition by various antipsychotic drugs of the G-protein-activated inwardly rectifying K(+) (GIRK) channels expressed in xenopus oocytes.
    British journal of pharmacology, 2000, Volume: 129, Issue:8

    Topics: Animals; Antipsychotic Agents; Brain; Clozapine; Dose-Response Relationship, Drug; G Protein-Coupled Inwardly-Rectifying Potassium Channels; GTP-Binding Proteins; Haloperidol; Heart; Mice; Oocytes; Pimozide; Potassium Channels; Potassium Channels, Inwardly Rectifying; RNA, Messenger; Thioridazine; Xenopus laevis

2000
QSAR model for drug human oral bioavailability.
    Journal of medicinal chemistry, 2000, Jun-29, Volume: 43, Issue:13

    Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship

2000
A comparison of the receptor binding and HERG channel affinities for a series of antipsychotic drugs.
    European journal of pharmacology, 2002, Aug-16, Volume: 450, Issue:1

    Topics: Animals; Antipsychotic Agents; Cation Transport Proteins; Cell Line; Clinical Trials as Topic; Cricetinae; DNA-Binding Proteins; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Humans; Long QT Syndrome; Patch-Clamp Techniques; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Voltage-Gated; Radioligand Assay; Receptor, Serotonin, 5-HT2A; Receptors, Dopamine D2; Receptors, Serotonin; Trans-Activators; Transcriptional Regulator ERG

2002
Toward a pharmacophore for drugs inducing the long QT syndrome: insights from a CoMFA study of HERG K(+) channel blockers.
    Journal of medicinal chemistry, 2002, Aug-29, Volume: 45, Issue:18

    Topics: Anti-Arrhythmia Agents; Cation Transport Proteins; Cluster Analysis; Databases, Factual; Ether-A-Go-Go Potassium Channels; Long QT Syndrome; Models, Molecular; Molecular Conformation; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Voltage-Gated; Quantitative Structure-Activity Relationship

2002
H1-histamine receptor affinity predicts short-term weight gain for typical and atypical antipsychotic drugs.
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2003, Volume: 28, Issue:3

    Topics: Animals; Antipsychotic Agents; Discriminant Analysis; Drug Evaluation, Preclinical; Forecasting; Humans; Protein Binding; Receptors, Histamine H1; Statistics, Nonparametric; Weight Gain

2003
Prediction of hERG potassium channel affinity by traditional and hologram qSAR methods.
    Bioorganic & medicinal chemistry letters, 2003, Aug-18, Volume: 13, Issue:16

    Topics: Cation Transport Proteins; Databases, Factual; Discriminant Analysis; Ether-A-Go-Go Potassium Channels; Holography; Linear Models; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Voltage-Gated; Quantitative Structure-Activity Relationship

2003
A two-state homology model of the hERG K+ channel: application to ligand binding.
    Bioorganic & medicinal chemistry letters, 2005, Mar-15, Volume: 15, Issue:6

    Topics: ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Ligands; Models, Biological; Models, Molecular; Potassium Channels, Voltage-Gated; Protein Binding; Protein Conformation

2005
A discriminant model constructed by the support vector machine method for HERG potassium channel inhibitors.
    Bioorganic & medicinal chemistry letters, 2005, Jun-02, Volume: 15, Issue:11

    Topics: Animals; CHO Cells; Cricetinae; Discriminant Analysis; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Humans; Potassium Channel Blockers; Potassium Channels, Voltage-Gated

2005
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling.
    Current drug discovery technologies, 2004, Volume: 1, Issue:4

    Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration

2004
Ureas with histamine H3-antagonist receptor activity--a new scaffold discovered by lead-hopping from cinnamic acid amides.
    Bioorganic & medicinal chemistry letters, 2006, Oct-15, Volume: 16, Issue:20

    Topics: Cinnamates; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Histamine Antagonists; Humans; Molecular Structure; Receptors, Histamine H3; Stereoisomerism; Structure-Activity Relationship; Thiazines; Urea

2006
Identification of new functional inhibitors of acid sphingomyelinase using a structure-property-activity relation model.
    Journal of medicinal chemistry, 2008, Jan-24, Volume: 51, Issue:2

    Topics: Algorithms; Animals; Cell Line; Cell Line, Tumor; Chemical Phenomena; Chemistry, Physical; Enzyme Inhibitors; Humans; Hydrogen-Ion Concentration; Molecular Conformation; Quantitative Structure-Activity Relationship; Rats; Sphingomyelin Phosphodiesterase

2008
Support vector machines classification of hERG liabilities based on atom types.
    Bioorganic & medicinal chemistry, 2008, Jun-01, Volume: 16, Issue:11

    Topics: Animals; Arrhythmias, Cardiac; CHO Cells; Computer Simulation; Cricetinae; Cricetulus; Discriminant Analysis; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Humans; Models, Chemical; Patch-Clamp Techniques; Potassium Channel Blockers; Potassium Channels, Voltage-Gated; Predictive Value of Tests; ROC Curve

2008
GRIND-based 3D-QSAR and CoMFA to investigate topics dominated by hydrophobic interactions: the case of hERG K+ channel blockers.
    European journal of medicinal chemistry, 2009, Volume: 44, Issue:5

    Topics: Ether-A-Go-Go Potassium Channels; Humans; Hydrophobic and Hydrophilic Interactions; Models, Molecular; Potassium Channel Blockers; Quantitative Structure-Activity Relationship

2009
Side chain flexibilities in the human ether-a-go-go related gene potassium channel (hERG) together with matched-pair binding studies suggest a new binding mode for channel blockers.
    Journal of medicinal chemistry, 2009, Jul-23, Volume: 52, Issue:14

    Topics: Binding Sites; Ether-A-Go-Go Potassium Channels; Humans; Hydrophobic and Hydrophilic Interactions; Ligands; Models, Molecular; Potassium Channel Blockers; Protein Binding; Protein Conformation

2009
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
    Chemical research in toxicology, 2010, Volume: 23, Issue:1

    Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship

2010
Predicting hERG activities of compounds from their 3D structures: development and evaluation of a global descriptors based QSAR model.
    European journal of medicinal chemistry, 2011, Volume: 46, Issue:2

    Topics: Computer Simulation; Ether-A-Go-Go Potassium Channels; Humans; Molecular Structure; Organic Chemicals; Quantitative Structure-Activity Relationship

2011
Simulation of multiple ion channel block provides improved early prediction of compounds' clinical torsadogenic risk.
    Cardiovascular research, 2011, Jul-01, Volume: 91, Issue:1

    Topics: Action Potentials; Animals; Calcium Channel Blockers; Calcium Channels, L-Type; Computer Simulation; Dogs; Dose-Response Relationship, Drug; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Guinea Pigs; HEK293 Cells; Humans; Ion Channels; Kinetics; Models, Cardiovascular; NAV1.5 Voltage-Gated Sodium Channel; Patch-Clamp Techniques; Potassium Channel Blockers; Rabbits; Risk Assessment; Risk Factors; Sodium Channel Blockers; Sodium Channels; Torsades de Pointes; Transfection

2011
Identifying a selective substrate and inhibitor pair for the evaluation of CYP2J2 activity.
    Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:5

    Topics: Amiodarone; Astemizole; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP2J2; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Danazol; Drug Discovery; Drug Interactions; Enzyme Inhibitors; Humans; Hydroxylation; In Vitro Techniques; Methylation; Microsomes, Liver; Models, Biological; Molecular Structure; Substrate Specificity; Tandem Mass Spectrometry; Terfenadine

2012
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
    Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:12

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship

2012
MICE models: superior to the HERG model in predicting Torsade de Pointes.
    Scientific reports, 2013, Volume: 3

    Topics: ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Humans; Models, Theoretical; Patch-Clamp Techniques; Predictive Value of Tests; Torsades de Pointes

2013
Potentiation by alpha-methyltyrosine of the suppression of food-reinforced lever-pressing behaviour induced by antipsychotic drugs.
    Acta pharmacologica et toxicologica, 1977, Volume: 40, Issue:1

    Topics: Animals; Antipsychotic Agents; Behavior, Animal; Bis(4-Methyl-1-Homopiperazinylthiocarbonyl)disulfide; Catecholamines; Chlorpromazine; Clozapine; Conditioning, Operant; Drug Synergism; Feeding Behavior; Haloperidol; Male; Methyltyrosines; Phenoxybenzamine; Pimozide; Rats; Receptors, Adrenergic; Thioridazine

1977
The different influence of predominantly antiadrenergic and antidopaminergic neuroleptics on the estrous cycle in rats.
    Pharmacology, 1977, Volume: 15, Issue:2

    Topics: Animals; Chlorpromazine; Diestrus; Dose-Response Relationship, Drug; Estrus; Female; Fluspirilene; Methotrimeprazine; Phenothiazines; Pimozide; Pregnancy; Pseudopregnancy; Rats; Receptors, Adrenergic; Thioridazine; Tranquilizing Agents

1977
Blockade of intracranial self-stimulation by antipsychotic drugs: failure to correlate with central alpha-noradrenergic blockade.
    Psychopharmacology, 1977, Aug-16, Volume: 53, Issue:3

    Topics: Animals; Antipsychotic Agents; Chlorpromazine; Clozapine; Depression, Chemical; Electric Stimulation; Male; Muscle Contraction; Phenoxybenzamine; Pimozide; Rats; Receptors, Adrenergic; Receptors, Adrenergic, alpha; Reflex; Self Stimulation; Thioridazine; Time Factors

1977
The effect of psychotropic drugs on the TSH-response to thyroliberin (TRH).
    Neuroendocrinology, 1977, Volume: 24, Issue:2

    Topics: Chlorpromazine; Fusaric Acid; Humans; Levodopa; Norepinephrine; Pimozide; Pituitary Gland, Anterior; Propranolol; Psychotropic Drugs; Receptors, Adrenergic; Receptors, Adrenergic, alpha; Thioridazine; Thyrotropin; Thyrotropin-Releasing Hormone

1977
[Prolonged action neuroleptics (review of the foreign literature)].
    Zhurnal nevropatologii i psikhiatrii imeni S.S. Korsakova (Moscow, Russia : 1952), 1975, Volume: 75, Issue:2

    Topics: Acute Disease; Antipsychotic Agents; Basal Ganglia Diseases; Bipolar Disorder; Child; Chronic Disease; Delayed-Action Preparations; Dibenzazepines; Dibenzothiepins; Dosage Forms; Drug Therapy, Combination; Fluphenazine; Humans; Paranoid Disorders; Perphenazine; Pimozide; Piperazines; Piperidines; Schizophrenia; Structure-Activity Relationship; Thioridazine; Thioxanthenes; Tranquilizing Agents

1975
Effect of thioridazine, clozapine and other antipsychotics on the kinetic state of tyrosine hydroxylase and on the turnover rate of dopamine in striatum and nucleus accumbens.
    The Journal of pharmacology and experimental therapeutics, 1975, Volume: 194, Issue:1

    Topics: Adenylyl Cyclases; Animals; Antipsychotic Agents; Brain; Brain Chemistry; Catecholamines; Chlorpromazine; Clozapine; Corpus Striatum; Dibenzothiepins; Dopamine; Dose-Response Relationship, Drug; Haloperidol; Hypothalamus; Kinetics; Male; Norepinephrine; Pimozide; Promethazine; Rats; Thioridazine; Tyrosine 3-Monooxygenase

1975
On the significance of the increase in homovanillic acid (HVA) caused by antipsychotic drugs in corpus striatum and limbic forebrain.
    Psychopharmacologia, 1975, Aug-21, Volume: 43, Issue:2

    Topics: Animals; Antipsychotic Agents; Basal Ganglia Diseases; Chlorpromazine; Clozapine; Corpus Striatum; Dextroamphetamine; Dopamine; Dose-Response Relationship, Drug; Haloperidol; Homovanillic Acid; Humans; Limbic System; Male; Phenylacetates; Pimozide; Rats; Receptors, Drug; Rotation; Stereotyped Behavior; Substantia Nigra; Thioridazine

1975
Effects of dopaminergic blocking agents on distal colon motility.
    Journal of clinical pharmacology, 1979, Volume: 19, Issue:10

    Topics: Adolescent; Adult; Biperiden; Colon; Dihydroergotamine; Dopamine Antagonists; Female; Gastrointestinal Motility; Haloperidol; Humans; Male; Middle Aged; Muscle Tonus; Pimozide; Sulpiride; Thioridazine

1979
A comparison of the abilities of typical neuroleptic agents and of thioridazine, clozapine, sulpiride and metoclopramide to antagonise the hyperactivity induced by dopamine applied intracerebrally to areas of the extrapyramidal and mesolimbic systems.
    European journal of pharmacology, 1976, Volume: 40, Issue:1

    Topics: Animals; Brain; Clozapine; Corpus Striatum; Dopamine Antagonists; Dose-Response Relationship, Drug; Extrapyramidal Tracts; Fluphenazine; Haloperidol; Limbic System; Male; Metoclopramide; Pimozide; Rats; Stereotaxic Techniques; Sulpiride; Thioridazine; Tranquilizing Agents

1976
Effect of neuroleptic drugs on mouse jumping induced by L-DOPA in amphetamine treated mice.
    Neuropharmacology, 1976, Volume: 15, Issue:11

    Topics: Amphetamine; Animals; Behavior; Chlorpromazine; Clozapine; Dose-Response Relationship, Drug; Drug Interactions; Haloperidol; Humans; Levodopa; Male; Mice; Pimozide; Promethazine; Psychotropic Drugs; Stereotyped Behavior; Thioridazine; Tranquilizing Agents

1976
The interaction of neuroleptic and muscarinic agents with central dopaminergic systems.
    British journal of pharmacology, 1975, Volume: 54, Issue:1

    Topics: Adenylyl Cyclase Inhibitors; Animals; Apomorphine; Behavior, Animal; Chlorpromazine; Clopenthixol; Clozapine; Corpus Striatum; Dopamine Antagonists; Dose-Response Relationship, Drug; Drug Interactions; Flupenthixol; Male; Methamphetamine; Models, Biological; Oxotremorine; Parasympathomimetics; Pimozide; Rats; Scopolamine; Substantia Nigra; Thioridazine; Tranquilizing Agents

1975
Detection of the nueroleptic properties of clozapine, sulpiride and thioridazine.
    Psychopharmacologia, 1975, Jul-23, Volume: 43, Issue:1

    Topics: Animals; Apomorphine; Behavior, Animal; Catalepsy; Clozapine; Dextroamphetamine; Dibenzazepines; Dose-Response Relationship, Drug; Drug Synergism; Fluphenazine; Haloperidol; Humans; Isoquinolines; Male; Methyltyrosines; Pimozide; Rats; Spiro Compounds; Stereotyped Behavior; Succinimides; Sulpiride; Thioridazine; Tranquilizing Agents

1975
Neuroleptic-induced changes in the anxiolytic and myorelaxant properties of diazepam in the rat.
    Pharmacology, biochemistry, and behavior, 1992, Volume: 41, Issue:1

    Topics: Animals; Anti-Anxiety Agents; Antipsychotic Agents; Chlorpromazine; Diazepam; Drug Interactions; Haloperidol; Male; Muscle Relaxants, Central; Pimozide; Rats; Thioridazine

1992
Tamoxifen-resistant human breast cancer cell growth: inhibition by thioridazine, pimozide and the calmodulin antagonist, W-13.
    The Journal of pharmacology and experimental therapeutics, 1992, Volume: 263, Issue:1

    Topics: Breast Neoplasms; Calmodulin; Cell Cycle; Cell Division; Drug Resistance; Flow Cytometry; Humans; Pimozide; Receptors, Estrogen; Sulfonamides; Thioridazine; Tumor Cells, Cultured

1992
Inhibition of human breast cancer cell proliferation in tissue culture by the neuroleptic agents pimozide and thioridazine.
    Cancer research, 1990, Sep-01, Volume: 50, Issue:17

    Topics: Antineoplastic Agents; Breast Neoplasms; Cell Division; Cell Line; DNA Replication; Estradiol; Female; Humans; Kinetics; Pimozide; Thioridazine; Thymidine; Tumor Cells, Cultured

1990
Antagonism of the amphetamine cue by both classical and atypical antipsychotic drugs.
    European journal of pharmacology, 1985, May-08, Volume: 111, Issue:2

    Topics: Animals; Antipsychotic Agents; Cues; Dextroamphetamine; Discrimination Learning; Dose-Response Relationship, Drug; Humans; Male; Metoclopramide; Pimozide; Rats; Rats, Inbred Strains; Receptors, Dopamine; Stereotyped Behavior; Thioridazine

1985
Behavioural microanalysis of the role of dopamine in amphetamine anorexia.
    Pharmacology, biochemistry, and behavior, 1988, Volume: 30, Issue:3

    Topics: Animals; Anorexia; Apomorphine; Dextroamphetamine; Dose-Response Relationship, Drug; Feeding and Eating Disorders; Feeding Behavior; Male; Pimozide; Rats; Rats, Inbred Strains; Reference Values; Thioridazine; Time Factors

1988
Susceptibility to drug-induced hypotension in post-partum psychosis.
    International clinical psychopharmacology, 1986, Volume: 1, Issue:1

    Topics: Adult; Chlorpromazine; Female; Humans; Hypotension, Orthostatic; Pimozide; Pregnancy; Psychotic Disorders; Psychotropic Drugs; Puerperal Disorders; Thioridazine; Trifluoperazine

1986
Late preventive effects of several anticalmodulin drugs on galactosamine-induced liver necrosis.
    Research communications in chemical pathology and pharmacology, 1985, Volume: 47, Issue:2

    Topics: Animals; Calmodulin; Galactosamine; Imipramine; Liver; Male; Necrosis; Pimozide; Rats; Thioridazine; Trifluoperazine

1985
Tardive dyskinesia controlled by anticholinergic agents.
    Clinical neuropharmacology, 1985, Volume: 8, Issue:4

    Topics: Adolescent; Benztropine; Bromazepam; Dyskinesia, Drug-Induced; Humans; Lightning; Male; Parasympatholytics; Pimozide; Thioridazine

1985
Anti-muscarinic properties of neuroleptics and drug-induced Parkinsonism.
    Nature, 1974, Apr-12, Volume: 248, Issue:449

    Topics: Adenylyl Cyclase Inhibitors; Animals; Atropine; Azirines; Benzoates; Benztropine; Cerebral Cortex; Corpus Striatum; Dibenzazepines; Ethanol; Extrapyramidal Tracts; In Vitro Techniques; Kinetics; Male; Parasympatholytics; Phenothiazines; Pimozide; Piperazines; Rats; Receptors, Drug; Spiro Compounds; Thioridazine; Thioxanthenes; Tranquilizing Agents; Trifluoperazine; Tritium

1974
Antipsychotic drugs stimulate prolactin release.
    Psychopharmacologia, 1974, Volume: 40, Issue:2

    Topics: Animals; Chlorpromazine; Dopamine; Female; Fluphenazine; Haloperidol; Male; Phenothiazines; Pimozide; Prolactin; Promethazine; Rats; Receptors, Drug; Sex Factors; Stimulation, Chemical; Sulpiride; Thiethylperazine; Thioridazine; Tranquilizing Agents

1974
Dopamine and the pharmacology of schizophrenia: the state of the evidence.
    Journal of psychiatric research, 1974, Volume: 11

    Topics: Amphetamine; Animals; Brain; Cats; Caudate Nucleus; Chlorpromazine; Dogs; Dopamine; Haloperidol; Haplorhini; Humans; Limbic System; Norepinephrine; Pimozide; Psychoses, Substance-Induced; Rats; Receptors, Drug; Schizophrenia; Species Specificity; Stereoisomerism; Stereotyped Behavior; Structure-Activity Relationship; Thiethylperazine; Thioridazine

1974
A comparison of pimozide and thioridazine as antagonists of amphetamine-induced stereotyped behavior in dogs.
    Archives internationales de pharmacodynamie et de therapie, 1973, Volume: 203, Issue:1

    Topics: Amphetamine; Animals; Behavior, Animal; Dogs; Female; Injections, Intramuscular; Male; Pimozide; Thioridazine

1973
Increase of 3-methoxy-4-hydroxyphenylethylene glycol in rat brain by neuroleptic drugs.
    European journal of pharmacology, 1973, Volume: 23, Issue:2

    Topics: Animals; Brain Chemistry; Chlorpromazine; Dibenzazepines; Dibenzothiepins; Dose-Response Relationship, Drug; Glycols; Haloperidol; Male; Methoxyhydroxyphenylglycol; Pimozide; Piperazines; Rats; Sulfides; Thioridazine; Tranquilizing Agents

1973
Antagonism of apomorphine-induced sterotypy and emesis in dogs by thioridazine, haloperidol, and pimozide.
    Psychopharmacologia, 1972, Volume: 26, Issue:2

    Topics: Animals; Apomorphine; Behavior, Animal; Blood-Brain Barrier; Chemoreceptor Cells; Corpus Striatum; Dogs; Drug Antagonism; Female; Haloperidol; Male; Pimozide; Premedication; Thioridazine; Time Factors; Tremor; Vomiting

1972
Cataleptogenic potency of the antipsychotic drugs is inversely correlated with neuronal activity in the amygdaloid complex of the rat.
    Pharmacology, biochemistry, and behavior, 1983, Volume: 19, Issue:5

    Topics: Action Potentials; Amygdala; Animals; Antipsychotic Agents; Catalepsy; Chlorpromazine; Clozapine; Dose-Response Relationship, Drug; Haloperidol; Humans; Male; Neurons; Pimozide; Rats; Rats, Inbred Strains; Thioridazine

1983
Neuroleptic-induced seizures. An in vitro technique for assessing relative risk.
    Archives of general psychiatry, 1982, Volume: 39, Issue:2

    Topics: Animals; Antipsychotic Agents; Butaclamol; Chlorpromazine; Culture Techniques; Dose-Response Relationship, Drug; Fluphenazine; Guinea Pigs; Haloperidol; Hippocampus; Male; Molindone; Pimozide; Seizures; Thioridazine

1982
Atypical neuroleptics clozapine and thioridazine enhance amphetamine-induced stereotypy.
    Pharmacology, biochemistry, and behavior, 1984, Volume: 21, Issue:1

    Topics: Animals; Clozapine; Dextroamphetamine; Dibenzazepines; Drug Interactions; Humans; Male; Motor Activity; Pimozide; Rats; Stereotyped Behavior; Thioridazine; Time Factors

1984
An hypothesis of the molecular structure of the dopamine receptor.
    Medical hypotheses, 1981, Volume: 7, Issue:12

    Topics: Apomorphine; Chemical Phenomena; Chemistry; Dopamine; Neurotensin; Pimozide; Receptors, Cholinergic; Receptors, Dopamine; Spiperone; Thioridazine

1981
Gilles de la Tourette disorder among individuals with severe or profound mental retardation.
    Mental retardation, 1993, Volume: 31, Issue:1

    Topics: Adult; Behavior Therapy; Combined Modality Therapy; Education of Intellectually Disabled; Female; Humans; Intellectual Disability; Male; Middle Aged; Pimozide; Thioridazine; Tourette Syndrome

1993
Practical application of guinea pig telemetry system for QT evaluation.
    The Journal of toxicological sciences, 2005, Volume: 30, Issue:3

    Topics: Animals; Anti-Arrhythmia Agents; Antipsychotic Agents; Bepridil; Cisapride; Disease Models, Animal; Electrocardiography; Guinea Pigs; Haloperidol; Heart; Humans; Injections, Intravenous; Long QT Syndrome; Male; Nifedipine; Pimozide; Piperidines; Pyridines; Quinidine; Reproducibility of Results; Telemetry; Terfenadine; Thioridazine

2005