Page last updated: 2024-08-22

pimozide and clozapine

pimozide has been researched along with clozapine in 80 studies

Research

Studies (80)

Timeframe	Studies, this research(%)	All Research%
pre-1990	28 (35.00)	18.7374
1990's	15 (18.75)	18.2507
2000's	24 (30.00)	29.6817
2010's	12 (15.00)	24.3611
2020's	1 (1.25)	2.80

Authors

Authors	Studies
Ellefson, CR; Kehr, JR; Miller, A; Woo, CM	1
Andrieux, M; Besançon, R; Giros, B; Martres, MP; Pilon, C; Schwartz, JC; Sokoloff, P	1
Bouthenet, ML; Giros, B; Martres, MP; Schwartz, JC; Sokoloff, P	1
Butler, DE; Coughenour, LL; DeWald, HA; Lewis, EP; Lobbestael, SJ; Nordin, IC; Pattison, IC; Poschel, BP; Wise, LD	1
Andrews, PR; Craik, DJ; Martin, JL	1
Choudhary, MS; Craigo, SC; Meltzer, HY; Monsma, FJ; Roth, BL; Shen, Y; Sibley, DR; Uluer, A	1
Emms, F; Freedman, SB; Knowles, MR; Marwood, R; McAllister, G; Patel, S; Seabrook, GR	1
Audinot, V; Chaput, C; Conte, C; Gavaudan, S; Millan, MJ; Newman-Tancredi, A; Touzard, M; Verrièle, L	1
Ikeda, K; Kobayashi, T; Kumanishi, T	1
Topliss, JG; Yoshida, F	1
Cavalli, A; De Ponti, F; Poluzzi, E; Recanatini, M	1
Ernsberger, P; Hufeisen, SJ; Jayathilake, K; Kroeze, WK; Meltzer, HY; Popadak, BA; Renock, SM; Roth, BL; Steinberg, S	1
Glennon, RA	1
Keserü, GM	1
Li, J; Rajamani, R; Reynolds, CH; Tounge, BA	1
Nagashima, R; Nishikawa, T; Tobita, M	1
Li, Y; Li, YH; Wang, YH; Yang, L; Yang, SL	1
Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL	1
Bellows, DS; Clarke, ID; Diamandis, P; Dirks, PB; Graham, J; Jamieson, LG; Ling, EK; Sacher, AG; Tyers, M; Ward, RJ; Wildenhain, J	1
Andricopulo, AD; Moda, TL; Montanari, CA	1
Cai, W; Hao, Y; Hu, P; Ma, D; Pan, H; Xie, X; Yu, AD; Yu, J; Yuan, J; Zhang, L; Zhu, H	1
Bleich, S; Gulbins, E; Kornhuber, J; Reichel, M; Terfloth, L; Tripal, P; Wiltfang, J	1
Jia, L; Sun, H	1
Caron, G; Ermondi, G; Visentin, S	1
Giordanetto, F; Leach, AG; Zachariae, U	1
Austin, CP; Fidock, DA; Hayton, K; Huang, R; Inglese, J; Jiang, H; Johnson, RL; Su, XZ; Wellems, TE; Wichterman, J; Yuan, J	1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A	1
Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ	1
Ekins, S; Williams, AJ; Xu, JJ	1
Sen, S; Sinha, N	1
Freiwald, S; Jiang, Y; Jones, JP; Kaspera, R; Katayama, J; Lee, CA; Smith, E; Totah, RA; Walker, GS	1
Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ	1
Brown, AM; Bruening-Wright, A; Kramer, J; Kuryshev, YA; Myatt, G; Obejero-Paz, CA; Verducci, JS	1
Bellman, K; Knegtel, RM; Settimo, L	1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K	1
Brodsky, JL; Chiang, A; Chung, WJ; Denny, RA; Goeckeler-Fried, JL; Havasi, V; Hong, JS; Keeton, AB; Mazur, M; Piazza, GA; Plyler, ZE; Rasmussen, L; Rowe, SM; Sorscher, EJ; Weissman, AM; White, EL	1
Grol, CJ; Rollema, H; Westerink, BH	1
Ahlenius, S; Engel, J	1
Setler, P; Weidley, E; Zarevics, P	1
Costa, E; Hong, JS; Yang, HT	1
Munday, KA; Poat, JA; Sumners, C; Woodruff, GN	1
Korf, J; Westerink, BH	1
Costa, E; Guidotti, A; Revuelta, A; Zivkovic, B	1
Dingell, JV; Hill, H; Robinson, SE; Setler, P; Stawarz, RJ; Sulser, F	1
Ellinwood, EH; Kilbey, MM	1
Gillin, JC; Moja, EA; Stoff, DM; Wyatt, RJ	1
Balakleevskiĭ, AI; Maslova, IV	1
Di Chiara, G; Gessa, GL; Morelli, M; Porceddu, ML	1
Costall, B; Naylor, RJ	2
Bianchi, S; Consolo, S; Ghezzi, D; Ladinsky, H	1
Fielding, S; Lal, H; Marky, M	1
Kelly, PH; Miller, RJ	1
Marsden, CD; Pycock, C; Tarsy, D	1
Pfaus, JG; Phillips, AG	1
Kaempf, GL; Porter, JH	1
Michael, RP; Schaefer, GJ	1
Berggren, U; Engel, J; Liljequist, S	1
Alloway, KD; Bashore, TR; Gelman, J; Rebec, GV	1
MacDonald, C; Robertson, A	1
Faustman, WO; Fowler, SC	1
Compton, AD; Porter, JH; Wiley, JL	1
Peterson, BS	1
McCoy, L; Richfield, EK	1
Cox, C; McCoy, L; Richfield, EK	2
Griffon, N; Pilon, C; Sautel, F; Schwartz, JC; Sokoloff, P	1
Ault, K; Friedman, J; Powchik, P	1
Bashir, K; Manyam, BV	1
Li, L; Schafer, JA	1
Bradley, RJ; Dwyer, DS; Liu, Y	1
Cory-Slechta, DA; Zuch, CL	1
Feuerbach, D; Loetscher, E; Mahé, C; Müller, W; Schoeffter, P; Seiler, MP	1
Lawrie, S; McIntosh, A; Nadeem, Z	1
Lawrie, S; McIntosh, A	1
Balit, CR; Isbister, GK; Kilham, HA	1
Hodneland, E; Holmsen, H; Oruch, R; Pryme, IF	1
Adler, DN; Alcantara, F; Bowler, S; Davis, KL; Friedman, JI; Harvey, PD; Iskander, A; Kaushik, S; Lindenmayer, JP; Novakovic, V; Novakovick, V; Parak, M; Parrella, M; Tsai, WY; Tsopelas, ND; White, L	1
D'Souza, DC; Forselius-Bielen, K; Gueorguieva, R; Gunduz-Bruce, H; Kaliora, S; Oliver, S; Petrides, G; Ray, S; Tek, C; Zimolo, Z	1
Osman, E; Yıldız, M	1

Reviews

6 review(s) available for pimozide and clozapine

Article	Year
Higher-end serotonin receptors: 5-HT(5), 5-HT(6), and 5-HT(7). Journal of medicinal chemistry, 2003, Jul-03, Volume: 46, Issue:14 Topics: Animals; Humans; Ligands; Receptors, Serotonin; Serotonin Agents; Serotonin Antagonists; Serotonin Receptor Agonists	2003
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug discovery today, 2016, Volume: 21, Issue:4 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk	2016
Considerations of natural history and pathophysiology in the psychopharmacology of Tourette's syndrome. The Journal of clinical psychiatry, 1996, Volume: 57 Suppl 9 Topics: Adolescent; Adult; Age of Onset; Antipsychotic Agents; Child; Clozapine; Disease Progression; Diseases in Twins; Dopamine; Haloperidol; Humans; Obsessive-Compulsive Disorder; Phenotype; Pimozide; Risperidone; Tourette Syndrome; Treatment Outcome	1996
Schizophrenia. Clinical evidence, 2003, Issue:10 Topics: Amisulpride; Antipsychotic Agents; Benzodiazepines; Chlorpromazine; Clozapine; Cognitive Behavioral Therapy; Dibenzothiepins; Haloperidol; Humans; Olanzapine; Patient Compliance; Perazine; Pimozide; Risperidone; Schizophrenia; Sulpiride	2003
Schizophrenia. Clinical evidence, 2004, Issue:12 Topics: Amisulpride; Antipsychotic Agents; Benzodiazepines; Chlorpromazine; Clozapine; Haloperidol; Humans; Olanzapine; Patient Compliance; Perazine; Pimozide; Risperidone; Schizophrenia; Sulpiride	2004
Antipsychotic poisoning in young children: a systematic review. Drug safety, 2005, Volume: 28, Issue:11 Topics: Antipsychotic Agents; Aripiprazole; Benzodiazepines; Child; Child, Preschool; Chlorpromazine; Clozapine; Dibenzothiazepines; Haloperidol; Humans; Infant; Infant, Newborn; Olanzapine; Pimozide; Piperazines; Poisoning; Quetiapine Fumarate; Quinolones; Risperidone	2005

Trials

3 trial(s) available for pimozide and clozapine

Article	Year
Pimozide augmentation for the treatment of schizophrenic patients who are partial responders to clozapine. Biological psychiatry, 1997, Sep-15, Volume: 42, Issue:6 Topics: Adult; Antipsychotic Agents; Clozapine; Drug Therapy, Combination; Female; Humans; Male; Middle Aged; Pimozide; Psychiatric Status Rating Scales; Schizophrenia; Schizophrenic Psychology	1997
Pimozide augmentation of clozapine inpatients with schizophrenia and schizoaffective disorder unresponsive to clozapine monotherapy. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2011, Volume: 36, Issue:6 Topics: Adult; Antipsychotic Agents; Brain; Clozapine; Double-Blind Method; Drug Resistance; Drug Synergism; Drug Therapy, Combination; Female; Humans; Male; Middle Aged; Pimozide; Placebos; Psychotic Disorders; Schizophrenia	2011
Efficacy of pimozide augmentation for clozapine partial responders with schizophrenia. Schizophrenia research, 2013, Volume: 143, Issue:2-3 Topics: Adult; Antipsychotic Agents; Brief Psychiatric Rating Scale; Clozapine; Double-Blind Method; Drug Synergism; Female; Humans; Male; Middle Aged; Neuropsychological Tests; Pimozide; Schizophrenia; Treatment Outcome	2013

Other Studies

71 other study(ies) available for pimozide and clozapine

Article	Year
Synthesis and biological evaluation of some 2-amino-4-aryl-3H-1,5-benzodiazepine analogues of clozapine. Journal of medicinal chemistry, 1978, Volume: 21, Issue:9 Topics: Adenylyl Cyclase Inhibitors; Animals; Antipsychotic Agents; Avoidance Learning; Brain; Clozapine; Corpus Striatum; Dextroamphetamine; Dibenzazepines; Dopamine; Dose-Response Relationship, Drug; In Vitro Techniques; Male; Mice; Rats	1978
Pharmacology of human dopamine D3 receptor expressed in a mammalian cell line: comparison with D2 receptor. European journal of pharmacology, 1992, Apr-10, Volume: 225, Issue:4 Topics: Animals; Chlorides; CHO Cells; Cricetinae; Dopamine; Dopamine Agents; Dopamine Antagonists; Guanylyl Imidodiphosphate; Humans; Lithium; Lithium Chloride; Receptors, Dopamine; Receptors, Dopamine D2; Receptors, Dopamine D3; Sodium Chloride; Sulpiride; Transfection	1992
Molecular cloning and characterization of a novel dopamine receptor (D3) as a target for neuroleptics. Nature, 1990, Sep-13, Volume: 347, Issue:6289 Topics: Amino Acid Sequence; Animals; Antipsychotic Agents; Base Sequence; Brain Chemistry; Cell Line; Cloning, Molecular; Cricetinae; DNA; DNA Restriction Enzymes; Dopamine; Guanylyl Imidodiphosphate; Molecular Sequence Data; Nucleic Acid Hybridization; Polymerase Chain Reaction; Rats; Receptors, Dopamine; Receptors, Dopamine D1; Receptors, Dopamine D2; Receptors, Dopamine D3; RNA, Messenger; Sequence Homology, Nucleic Acid; Tissue Distribution	1990
1-[3-(Diarylamino)propyl]piperidines and related compounds, potential antipsychotic agents with low cataleptogenic profiles. Journal of medicinal chemistry, 1985, Volume: 28, Issue:5 Topics: Animals; Antipsychotic Agents; Basal Ganglia Diseases; Binding, Competitive; Catalepsy; Corpus Striatum; Haloperidol; Humans; In Vitro Techniques; Male; Mice; Motor Activity; Piperazines; Piperidines; Rats; Receptors, Dopamine; Self Stimulation; Structure-Activity Relationship	1985
Functional group contributions to drug-receptor interactions. Journal of medicinal chemistry, 1984, Volume: 27, Issue:12 Topics: Animals; Calorimetry; Kinetics; Models, Biological; Protein Binding; Receptors, Cell Surface; Receptors, Drug; Structure-Activity Relationship	1984
Binding of typical and atypical antipsychotic agents to 5-hydroxytryptamine-6 and 5-hydroxytryptamine-7 receptors. The Journal of pharmacology and experimental therapeutics, 1994, Volume: 268, Issue:3 Topics: Animals; Antipsychotic Agents; Cell Line; Molecular Structure; Rats; Receptors, Serotonin	1994
Expression and pharmacological characterization of the human D3 dopamine receptor. The Journal of pharmacology and experimental therapeutics, 1994, Volume: 268, Issue:1 Topics: Animals; Binding, Competitive; Cells, Cultured; CHO Cells; Cricetinae; Dopamine; Dopamine Antagonists; GTP-Binding Proteins; Guanine Nucleotides; Humans; Potassium Channels; Rats; Receptors, Dopamine; Receptors, Dopamine D2; Receptors, Dopamine D3; Recombinant Proteins; Second Messenger Systems; Sulpiride	1994
Agonist and antagonist actions of antipsychotic agents at 5-HT1A receptors: a [35S]GTPgammaS binding study. European journal of pharmacology, 1998, Aug-21, Volume: 355, Issue:2-3 Topics: Animals; Antipsychotic Agents; CHO Cells; Cricetinae; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Serotonin Agents; Sulfur Radioisotopes	1998
Inhibition by various antipsychotic drugs of the G-protein-activated inwardly rectifying K(+) (GIRK) channels expressed in xenopus oocytes. British journal of pharmacology, 2000, Volume: 129, Issue:8 Topics: Animals; Antipsychotic Agents; Brain; Clozapine; Dose-Response Relationship, Drug; G Protein-Coupled Inwardly-Rectifying Potassium Channels; GTP-Binding Proteins; Haloperidol; Heart; Mice; Oocytes; Pimozide; Potassium Channels; Potassium Channels, Inwardly Rectifying; RNA, Messenger; Thioridazine; Xenopus laevis	2000
QSAR model for drug human oral bioavailability. Journal of medicinal chemistry, 2000, Jun-29, Volume: 43, Issue:13 Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship	2000
Toward a pharmacophore for drugs inducing the long QT syndrome: insights from a CoMFA study of HERG K(+) channel blockers. Journal of medicinal chemistry, 2002, Aug-29, Volume: 45, Issue:18 Topics: Anti-Arrhythmia Agents; Cation Transport Proteins; Cluster Analysis; Databases, Factual; Ether-A-Go-Go Potassium Channels; Long QT Syndrome; Models, Molecular; Molecular Conformation; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Voltage-Gated; Quantitative Structure-Activity Relationship	2002
H1-histamine receptor affinity predicts short-term weight gain for typical and atypical antipsychotic drugs. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2003, Volume: 28, Issue:3 Topics: Animals; Antipsychotic Agents; Discriminant Analysis; Drug Evaluation, Preclinical; Forecasting; Humans; Protein Binding; Receptors, Histamine H1; Statistics, Nonparametric; Weight Gain	2003
Prediction of hERG potassium channel affinity by traditional and hologram qSAR methods. Bioorganic & medicinal chemistry letters, 2003, Aug-18, Volume: 13, Issue:16 Topics: Cation Transport Proteins; Databases, Factual; Discriminant Analysis; Ether-A-Go-Go Potassium Channels; Holography; Linear Models; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Voltage-Gated; Quantitative Structure-Activity Relationship	2003
A two-state homology model of the hERG K+ channel: application to ligand binding. Bioorganic & medicinal chemistry letters, 2005, Mar-15, Volume: 15, Issue:6 Topics: ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Ligands; Models, Biological; Models, Molecular; Potassium Channels, Voltage-Gated; Protein Binding; Protein Conformation	2005
A discriminant model constructed by the support vector machine method for HERG potassium channel inhibitors. Bioorganic & medicinal chemistry letters, 2005, Jun-02, Volume: 15, Issue:11 Topics: Animals; CHO Cells; Cricetinae; Discriminant Analysis; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Humans; Potassium Channel Blockers; Potassium Channels, Voltage-Gated	2005
Modeling K(m) values using electrotopological state: substrates for cytochrome P450 3A4-mediated metabolism. Bioorganic & medicinal chemistry letters, 2005, Sep-15, Volume: 15, Issue:18 Topics: Computational Biology; Cyclohexanols; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Molecular Structure; Principal Component Analysis; Pyrrolizidine Alkaloids; Quantitative Structure-Activity Relationship; Reproducibility of Results; Substrate Specificity; Venlafaxine Hydrochloride	2005
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling. Current drug discovery technologies, 2004, Volume: 1, Issue:4 Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration	2004
Chemical genetics reveals a complex functional ground state of neural stem cells. Nature chemical biology, 2007, Volume: 3, Issue:5 Topics: Animals; Cell Survival; Cells, Cultured; Mice; Molecular Structure; Neoplasms; Neurons; Pharmaceutical Preparations; Sensitivity and Specificity; Stem Cells	2007
Hologram QSAR model for the prediction of human oral bioavailability. Bioorganic & medicinal chemistry, 2007, Dec-15, Volume: 15, Issue:24 Topics: Administration, Oral; Biological Availability; Holography; Humans; Models, Biological; Models, Molecular; Molecular Structure; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship	2007
Small molecule regulators of autophagy identified by an image-based high-throughput screen. Proceedings of the National Academy of Sciences of the United States of America, 2007, Nov-27, Volume: 104, Issue:48 Topics: Autophagy; Calcium Channel Blockers; Cell Line, Tumor; Drug Evaluation, Preclinical; Fluspirilene; Glioblastoma; Green Fluorescent Proteins; Humans; Intracellular Membranes; Loperamide; Microtubule-Associated Proteins; Mycotoxins; Peptides; Phagosomes; Phosphatidylinositol Phosphates; Pimozide; Protein Kinases; Recombinant Fusion Proteins; Sirolimus; Small Molecule Libraries; TOR Serine-Threonine Kinases; Trifluoperazine; Zinc Fingers	2007
Identification of new functional inhibitors of acid sphingomyelinase using a structure-property-activity relation model. Journal of medicinal chemistry, 2008, Jan-24, Volume: 51, Issue:2 Topics: Algorithms; Animals; Cell Line; Cell Line, Tumor; Chemical Phenomena; Chemistry, Physical; Enzyme Inhibitors; Humans; Hydrogen-Ion Concentration; Molecular Conformation; Quantitative Structure-Activity Relationship; Rats; Sphingomyelin Phosphodiesterase	2008
Support vector machines classification of hERG liabilities based on atom types. Bioorganic & medicinal chemistry, 2008, Jun-01, Volume: 16, Issue:11 Topics: Animals; Arrhythmias, Cardiac; CHO Cells; Computer Simulation; Cricetinae; Cricetulus; Discriminant Analysis; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Humans; Models, Chemical; Patch-Clamp Techniques; Potassium Channel Blockers; Potassium Channels, Voltage-Gated; Predictive Value of Tests; ROC Curve	2008
GRIND-based 3D-QSAR and CoMFA to investigate topics dominated by hydrophobic interactions: the case of hERG K+ channel blockers. European journal of medicinal chemistry, 2009, Volume: 44, Issue:5 Topics: Ether-A-Go-Go Potassium Channels; Humans; Hydrophobic and Hydrophilic Interactions; Models, Molecular; Potassium Channel Blockers; Quantitative Structure-Activity Relationship	2009
Side chain flexibilities in the human ether-a-go-go related gene potassium channel (hERG) together with matched-pair binding studies suggest a new binding mode for channel blockers. Journal of medicinal chemistry, 2009, Jul-23, Volume: 52, Issue:14 Topics: Binding Sites; Ether-A-Go-Go Potassium Channels; Humans; Hydrophobic and Hydrophilic Interactions; Ligands; Models, Molecular; Potassium Channel Blockers; Protein Binding; Protein Conformation	2009
Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum. Nature chemical biology, 2009, Volume: 5, Issue:10 Topics: Animals; Antimalarials; ATP Binding Cassette Transporter, Subfamily B, Member 1; Chromosome Mapping; Crosses, Genetic; Dihydroergotamine; Drug Design; Drug Resistance; Humans; Inhibitory Concentration 50; Mutation; Plasmodium falciparum; Quantitative Trait Loci; Transfection	2009
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Chemical research in toxicology, 2010, Volume: 23, Issue:1 Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship	2010
Developing structure-activity relationships for the prediction of hepatotoxicity. Chemical research in toxicology, 2010, Jul-19, Volume: 23, Issue:7 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes	2010
A predictive ligand-based Bayesian model for human drug-induced liver injury. Drug metabolism and disposition: the biological fate of chemicals, 2010, Volume: 38, Issue:12 Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands	2010
Predicting hERG activities of compounds from their 3D structures: development and evaluation of a global descriptors based QSAR model. European journal of medicinal chemistry, 2011, Volume: 46, Issue:2 Topics: Computer Simulation; Ether-A-Go-Go Potassium Channels; Humans; Molecular Structure; Organic Chemicals; Quantitative Structure-Activity Relationship	2011
Identifying a selective substrate and inhibitor pair for the evaluation of CYP2J2 activity. Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:5 Topics: Amiodarone; Astemizole; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP2J2; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Danazol; Drug Discovery; Drug Interactions; Enzyme Inhibitors; Humans; Hydroxylation; In Vitro Techniques; Methylation; Microsomes, Liver; Models, Biological; Molecular Structure; Substrate Specificity; Tandem Mass Spectrometry; Terfenadine	2012
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification. Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:12 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship	2012
MICE models: superior to the HERG model in predicting Torsade de Pointes. Scientific reports, 2013, Volume: 3 Topics: ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Humans; Models, Theoretical; Patch-Clamp Techniques; Predictive Value of Tests; Torsades de Pointes	2013
Comparison of the accuracy of experimental and predicted pKa values of basic and acidic compounds. Pharmaceutical research, 2014, Volume: 31, Issue:4 Topics: Chemistry, Pharmaceutical; Forecasting; Hydrogen-Ion Concentration; Pharmaceutical Preparations; Random Allocation	2014
Increasing the Endoplasmic Reticulum Pool of the F508del Allele of the Cystic Fibrosis Transmembrane Conductance Regulator Leads to Greater Folding Correction by Small Molecule Therapeutics. PloS one, 2016, Volume: 11, Issue:10 Topics: Alleles; Benzoates; Cells, Cultured; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Endoplasmic Reticulum; Furans; Gene Deletion; HEK293 Cells; HeLa Cells; High-Throughput Screening Assays; Humans; Hydroxamic Acids; Microscopy, Fluorescence; Protein Folding; Protein Structure, Tertiary; Pyrazoles; RNA, Messenger; Small Molecule Libraries; Ubiquitination; Vorinostat	2016
Correlation between neuroleptic-induced suppression of stereotyped behaviour and HVA concentrations in rat brain. The Journal of pharmacy and pharmacology, 1976, Volume: 28, Issue:4 Topics: Amphetamines; Animals; Antipsychotic Agents; Apomorphine; Behavior; Brain Chemistry; Clozapine; Depression, Chemical; Haloperidol; Homovanillic Acid; Humans; Male; Phenothiazines; Phenylacetates; Pimozide; Rats; Stereotyped Behavior; Tranquilizing Agents	1976
Potentiation by alpha-methyltyrosine of the suppression of food-reinforced lever-pressing behaviour induced by antipsychotic drugs. Acta pharmacologica et toxicologica, 1977, Volume: 40, Issue:1 Topics: Animals; Antipsychotic Agents; Behavior, Animal; Bis(4-Methyl-1-Homopiperazinylthiocarbonyl)disulfide; Catecholamines; Chlorpromazine; Clozapine; Conditioning, Operant; Drug Synergism; Feeding Behavior; Haloperidol; Male; Methyltyrosines; Phenoxybenzamine; Pimozide; Rats; Receptors, Adrenergic; Thioridazine	1977
Blockade of intracranial self-stimulation by antipsychotic drugs: failure to correlate with central alpha-noradrenergic blockade. Psychopharmacology, 1977, Aug-16, Volume: 53, Issue:3 Topics: Animals; Antipsychotic Agents; Chlorpromazine; Clozapine; Depression, Chemical; Electric Stimulation; Male; Muscle Contraction; Phenoxybenzamine; Pimozide; Rats; Receptors, Adrenergic; Receptors, Adrenergic, alpha; Reflex; Self Stimulation; Thioridazine; Time Factors	1977
Substance P content of substantia nigra after chronic treatment with antischizophrenic drugs. Neuropharmacology, 1978, Volume: 17, Issue:1 Topics: Animals; Antipsychotic Agents; Clozapine; Haloperidol; Male; Pimozide; Rats; Substance P; Substantia Nigra; Time Factors	1978
The effect of neuroleptic drugs on drinking induced by central administration of angiotensin or carbachol. Psychopharmacology, 1979, Feb-28, Volume: 60, Issue:3 Topics: Angiotensin II; Animals; Antipsychotic Agents; Carbachol; Chlorpromazine; Clozapine; Dopamine; Drinking Behavior; Flupenthixol; Fluphenazine; Haloperidol; Injections, Intraperitoneal; Injections, Intraventricular; Male; Pimozide; Rats; Sulpiride	1979
Influence of drugs on striatal and limbic homovanillic acid concentration in the rat brain. European journal of pharmacology, 1975, Volume: 33, Issue:1 Topics: Aminooxyacetic Acid; Animals; Atropine; Brain; Brain Chemistry; Clozapine; Corpus Striatum; Fenclonine; Haloperidol; Homovanillic Acid; Limbic System; Male; Morphine; Oxotremorine; Phenylacetates; Physostigmine; Pimozide; Probenecid; Rats; Substantia Nigra; Trihexyphenidyl	1975
Effect of thioridazine, clozapine and other antipsychotics on the kinetic state of tyrosine hydroxylase and on the turnover rate of dopamine in striatum and nucleus accumbens. The Journal of pharmacology and experimental therapeutics, 1975, Volume: 194, Issue:1 Topics: Adenylyl Cyclases; Animals; Antipsychotic Agents; Brain; Brain Chemistry; Catecholamines; Chlorpromazine; Clozapine; Corpus Striatum; Dibenzothiepins; Dopamine; Dose-Response Relationship, Drug; Haloperidol; Hypothalamus; Kinetics; Male; Norepinephrine; Pimozide; Promethazine; Rats; Thioridazine; Tyrosine 3-Monooxygenase	1975
On the significance of the increase in homovanillic acid (HVA) caused by antipsychotic drugs in corpus striatum and limbic forebrain. Psychopharmacologia, 1975, Aug-21, Volume: 43, Issue:2 Topics: Animals; Antipsychotic Agents; Basal Ganglia Diseases; Chlorpromazine; Clozapine; Corpus Striatum; Dextroamphetamine; Dopamine; Dose-Response Relationship, Drug; Haloperidol; Homovanillic Acid; Humans; Limbic System; Male; Phenylacetates; Pimozide; Rats; Receptors, Drug; Rotation; Stereotyped Behavior; Substantia Nigra; Thioridazine	1975
Alteration in motor frequencies with dopamine agonists and antagonists [proceedings]. Psychopharmacology bulletin, 1979, Volume: 15, Issue:2 Topics: Animals; Clozapine; Dextroamphetamine; Dopamine; Dopamine Antagonists; Motor Activity; Pimozide; Rats	1979
Neuroleptics attentuate stereotyped behavior induced by beta-phenylethylamine in rats. Biological psychiatry, 1978, Volume: 13, Issue:2 Topics: Animals; Behavior; Chlorpromazine; Clozapine; Diazepam; Dose-Response Relationship, Drug; Drug Antagonism; Drug Evaluation; Haloperidol; Humans; Male; Phenethylamines; Pimozide; Rats; Receptors, Dopamine; Stereotyped Behavior; Tranquilizing Agents	1978
[Effect of neuroleptics on acetylcholine metabolism in the basal ganglia of the brain]. Biulleten' eksperimental'noi biologii i meditsiny, 1978, Volume: 85, Issue:4 Topics: Acetylcholine; Acetylcholinesterase; Animals; Basal Ganglia; Chlorpromazine; Clozapine; Haloperidol; Male; Pimozide; Rats; Tranquilizing Agents	1978
Self-inhibitory dopamine-receptors and central effects of apomorphine. Annali dell'Istituto superiore di sanita, 1978, Volume: 14, Issue:1 Topics: Animals; Apomorphine; Benperidol; Brain; Clozapine; Droperidol; Exploratory Behavior; Haloperidol; Humans; Mice; Motor Activity; Pimozide; Rats; Receptors, Dopamine; Sleep	1978
A comparison of the abilities of typical neuroleptic agents and of thioridazine, clozapine, sulpiride and metoclopramide to antagonise the hyperactivity induced by dopamine applied intracerebrally to areas of the extrapyramidal and mesolimbic systems. European journal of pharmacology, 1976, Volume: 40, Issue:1 Topics: Animals; Brain; Clozapine; Corpus Striatum; Dopamine Antagonists; Dose-Response Relationship, Drug; Extrapyramidal Tracts; Fluphenazine; Haloperidol; Limbic System; Male; Metoclopramide; Pimozide; Rats; Stereotaxic Techniques; Sulpiride; Thioridazine; Tranquilizing Agents	1976
Apparent lack of a dopaminergic-cholinergic link in the rat nucleus accumbens septi-tuberculum olfactorium. Brain research, 1977, Oct-28, Volume: 135, Issue:2 Topics: Acetylcholine; Animals; Apomorphine; Bromocriptine; Chlorpromazine; Clozapine; Dextroamphetamine; Haloperidol; Nucleus Accumbens; Olfactory Bulb; Pimozide; Piribedil; Rats; Receptors, Cholinergic; Receptors, Dopamine; Septal Nuclei	1977
Effect of neuroleptic drugs on mouse jumping induced by L-DOPA in amphetamine treated mice. Neuropharmacology, 1976, Volume: 15, Issue:11 Topics: Amphetamine; Animals; Behavior; Chlorpromazine; Clozapine; Dose-Response Relationship, Drug; Drug Interactions; Haloperidol; Humans; Levodopa; Male; Mice; Pimozide; Promethazine; Psychotropic Drugs; Stereotyped Behavior; Thioridazine; Tranquilizing Agents	1976
The interaction of neuroleptic and muscarinic agents with central dopaminergic systems. British journal of pharmacology, 1975, Volume: 54, Issue:1 Topics: Adenylyl Cyclase Inhibitors; Animals; Apomorphine; Behavior, Animal; Chlorpromazine; Clopenthixol; Clozapine; Corpus Striatum; Dopamine Antagonists; Dose-Response Relationship, Drug; Drug Interactions; Flupenthixol; Male; Methamphetamine; Models, Biological; Oxotremorine; Parasympathomimetics; Pimozide; Rats; Scopolamine; Substantia Nigra; Thioridazine; Tranquilizing Agents	1975
Detection of the nueroleptic properties of clozapine, sulpiride and thioridazine. Psychopharmacologia, 1975, Jul-23, Volume: 43, Issue:1 Topics: Animals; Apomorphine; Behavior, Animal; Catalepsy; Clozapine; Dextroamphetamine; Dibenzazepines; Dose-Response Relationship, Drug; Drug Synergism; Fluphenazine; Haloperidol; Humans; Isoquinolines; Male; Methyltyrosines; Pimozide; Rats; Spiro Compounds; Stereotyped Behavior; Succinimides; Sulpiride; Thioridazine; Tranquilizing Agents	1975
Inhibition of circling behavior by neuroleptic drugs in mice with unilateral 6-hydroxydopamine lesions of the striatum. Psychopharmacologia, 1975, Dec-31, Volume: 45, Issue:2 Topics: Animals; Apomorphine; Basal Ganglia Diseases; Behavior; Biogenic Amines; Bis(4-Methyl-1-Homopiperazinylthiocarbonyl)disulfide; Chlorpromazine; Clozapine; Corpus Striatum; Dextroamphetamine; Diazepam; Dopamine; Haloperidol; Humans; Hydroxydopamines; Levodopa; Male; Metoclopramide; Mice; Motor Activity; Pentobarbital; Phenoxybenzamine; Pimozide; Promethazine; Stereotyped Behavior; Tranquilizing Agents	1975
Differential effects of dopamine receptor antagonists on the sexual behavior of male rats. Psychopharmacology, 1989, Volume: 98, Issue:3 Topics: Animals; Antipsychotic Agents; Clozapine; Ejaculation; Female; Haloperidol; Male; Metoclopramide; Pimozide; Rats; Rats, Inbred Strains; Receptors, Dopamine; Sexual Behavior, Animal; Sulpiride	1989
Differential effects of pimozide and clozapine on schedule-controlled and scheduled-induced behaviors after acute and chronic administration. The Journal of pharmacology and experimental therapeutics, 1987, Volume: 243, Issue:2 Topics: Animals; Behavior, Animal; Clozapine; Conditioning, Operant; Dibenzazepines; Drinking; Male; Motor Activity; Pimozide; Rats; Reinforcement, Psychology	1987
Acute effects of neuroleptics on brain self-stimulation thresholds in rats. Psychopharmacology, 1980, Volume: 67, Issue:1 Topics: Animals; Antipsychotic Agents; Brain; Chlorpromazine; Clozapine; Haloperidol; Loxapine; Male; Pimozide; Rats; Self Stimulation	1980
The effect of catecholamine receptor antagonists on ethanol-induced locomotor stimulation. Journal of neural transmission, 1981, Volume: 50, Issue:1 Topics: Adrenergic alpha-Antagonists; Animals; Antipsychotic Agents; Clozapine; Dose-Response Relationship, Drug; Ethanol; Female; Haloperidol; Locomotion; Mice; Phenoxybenzamine; Pimozide; Receptors, Adrenergic; Receptors, Dopamine; Yohimbine	1981
Cataleptogenic potency of the antipsychotic drugs is inversely correlated with neuronal activity in the amygdaloid complex of the rat. Pharmacology, biochemistry, and behavior, 1983, Volume: 19, Issue:5 Topics: Action Potentials; Amygdala; Animals; Antipsychotic Agents; Catalepsy; Chlorpromazine; Clozapine; Dose-Response Relationship, Drug; Haloperidol; Humans; Male; Neurons; Pimozide; Rats; Rats, Inbred Strains; Thioridazine	1983
Atypical neuroleptics clozapine and thioridazine enhance amphetamine-induced stereotypy. Pharmacology, biochemistry, and behavior, 1984, Volume: 21, Issue:1 Topics: Animals; Clozapine; Dextroamphetamine; Dibenzazepines; Drug Interactions; Humans; Male; Motor Activity; Pimozide; Rats; Stereotyped Behavior; Thioridazine; Time Factors	1984
An examination of methodological refinements, clozapine and fluphenazine in the anhedonia paradigm. Pharmacology, biochemistry, and behavior, 1982, Volume: 17, Issue:5 Topics: Animals; Clozapine; Conditioning, Operant; Dibenzazepines; Dose-Response Relationship, Drug; Emotions; Extinction, Psychological; Fluphenazine; Male; Pimozide; Rats; Rats, Inbred Strains; Reinforcement Schedule	1982
Differential effects of clozapine and pimozide on fixed-ratio responding during repeated dosing. Pharmacology, biochemistry, and behavior, 1994, Volume: 48, Issue:1 Topics: Animals; Clozapine; Conditioning, Operant; Drug Tolerance; Male; Pimozide; Rats; Rats, Sprague-Dawley; Reinforcement Schedule	1994
Chronic antipsychotic treatment alters glycine-stimulated NMDA receptor binding in rat brain. Neuroscience letters, 1996, Aug-02, Volume: 213, Issue:2 Topics: Analysis of Variance; Animals; Antipsychotic Agents; Autoradiography; Binding, Competitive; Brain Chemistry; Clozapine; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Glycine; Haloperidol; Male; Pimozide; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Risperidone; Time Factors; Tritium	1996
Chronic treatment with typical and atypical antipsychotics increases the AMPA-preferring form of AMPA receptor in rat brain. European journal of pharmacology, 1996, Dec-27, Volume: 318, Issue:1 Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Antipsychotic Agents; Brain; Clozapine; Haloperidol; Male; Pimozide; Protein Binding; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Risperidone; Tritium	1996
Antipsychotics with inverse agonist activity at the dopamine D3 receptor. Journal of neural transmission (Vienna, Austria : 1996), 1996, Volume: 103, Issue:10 Topics: Animals; Antipsychotic Agents; Calcium; CHO Cells; Clozapine; Colforsin; Cricetinae; Cyclic AMP; DNA Replication; Dopamine Agonists; Dopamine Antagonists; Dose-Response Relationship, Drug; Flupenthixol; Glioma; Haloperidol; Humans; Hybrid Cells; Naphthalenes; Neuroblastoma; Pertussis Toxin; Phenothiazines; Pimozide; Pyrrolidines; Quinpirole; Receptors, Dopamine D2; Receptors, Dopamine D3; Recombinant Proteins; Risperidone; Salicylamides; Second Messenger Systems; Sulpiride; Tetrahydronaphthalenes; Tumor Cells, Cultured; Virulence Factors, Bordetella	1996
Clozapine for the control of hemiballismus. Clinical neuropharmacology, 1994, Volume: 17, Issue:5 Topics: Adult; Anticonvulsants; Antipsychotic Agents; Clozapine; Haloperidol; Humans; Hypnotics and Sedatives; Male; Movement Disorders; Phenobarbital; Pimozide	1994
Antipsychotic drug regulation of AMPA receptor affinity states and GluR1, GluR2 splice variant expression. Synapse (New York, N.Y.), 1998, Volume: 28, Issue:3 Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Alternative Splicing; Animals; Antipsychotic Agents; Autoradiography; Binding, Competitive; Brain Chemistry; Clozapine; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Gene Expression; Haloperidol; In Situ Hybridization; Male; Pimozide; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Risperidone; RNA, Messenger; Sodium Chloride; Tritium	1998
Dopamine inhibits vasopressin-dependent cAMP production in the rat cortical collecting duct. The American journal of physiology, 1998, Volume: 275, Issue:1 Topics: Alkaloids; Animals; Arginine Vasopressin; Benzophenanthridines; Clozapine; Cyclic AMP; Dopamine; Dopamine Antagonists; Dopamine D2 Receptor Antagonists; Enzyme Inhibitors; Epinephrine; Fenoldopam; GTP-Binding Proteins; In Vitro Techniques; Kidney Cortex; Kidney Tubules, Collecting; Kinetics; Male; Naphthalenes; Phenanthridines; Pimozide; Protein Kinase C; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D1; Receptors, Dopamine D3; Receptors, Dopamine D4; Spiperone; Time Factors; Yohimbine	1998
Dopamine receptor antagonists modulate glucose uptake in rat pheochromocytoma (PC12) cells. Neuroscience letters, 1999, Oct-29, Volume: 274, Issue:3 Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Antipsychotic Agents; Benzazepines; Biological Transport; Chlorpromazine; Clozapine; Dizocilpine Maleate; Dopamine Agonists; Dopamine Antagonists; Dopamine D2 Receptor Antagonists; Excitatory Amino Acid Antagonists; Fluphenazine; Glucose; Haloperidol; PC12 Cells; Pimozide; Rats; Receptors, Dopamine D2; Spiperone; Sulpiride; Tritium	1999
Stimulus properties of 7-OH-DPAT versus auto- and postsynaptic receptor-specific doses of quinpirole. Pharmacology, biochemistry, and behavior, 2001, Volume: 68, Issue:3 Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Clozapine; Dopamine Antagonists; Female; Haloperidol; Maternal Behavior; Motivation; Motor Activity; Pimozide; Rats	2001
Differential inverse agonist efficacies of SB-258719, SB-258741 and SB-269970 at human recombinant serotonin 5-HT7 receptors. European journal of pharmacology, 2004, Jul-14, Volume: 495, Issue:2-3 Topics: Animals; Binding, Competitive; CHO Cells; Clozapine; Cricetinae; Cricetulus; Cyclic AMP; Dose-Response Relationship, Drug; Ergolines; Humans; Loxapine; Methiothepin; Phenols; Pimozide; Pindolol; Piperidines; Plasmids; Pyrrolidines; Radioligand Assay; Receptors, Serotonin; Ritanserin; Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists; Sulfonamides; Tosyl Compounds; Transfection	2004
Psychotropic drugs interfere with the tight coupling of polyphosphoinositide cycle metabolites in human platelets: a result of receptor-independent drug intercalation in the plasma membrane? Biochimica et biophysica acta, 2008, Volume: 1778, Issue:10 Topics: Antipsychotic Agents; Blood Platelets; Cell Membrane; Chlorpromazine; Clozapine; Dibenzothiazepines; Haloperidol; Humans; Molecular Structure; Phosphatidylinositol Phosphates; Pimozide; Prochlorperazine; Psychotropic Drugs; Quetiapine Fumarate; Signal Transduction; Thrombin; Trifluoperazine	2008
Letter to the Editor: Rethinking The Cost Of Antipsychotic Treatment: The Average Cost Of The Drugs Used In Turkey In 2020. Turk psikiyatri dergisi = Turkish journal of psychiatry, 2022,Summer, Volume: 33, Issue:2 Topics: Adenosine Monophosphate; Adult; Amisulpride; Antipsychotic Agents; Aripiprazole; Benzodiazepines; Chlorpromazine; Clopenthixol; Clozapine; Flupenthixol; Fluphenazine; Haloperidol; Humans; Olanzapine; Paliperidone Palmitate; Pharmaceutical Preparations; Pimozide; Quetiapine Fumarate; Risperidone; Sulpiride; Trifluoperazine	2022