Page last updated: 2024-08-16

pimobendan and isoproterenol

pimobendan has been researched along with isoproterenol in 22 studies

Research

Studies (22)

TimeframeStudies, this research(%)All Research%
pre-19909 (40.91)18.7374
1990's10 (45.45)18.2507
2000's1 (4.55)29.6817
2010's2 (9.09)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Lombardo, F; Obach, RS; Waters, NJ1
Eschenhagen, T; Mende, U; Müller, FU; Neumann, J; Schmitz, W; Scholz, H1
Fujimoto, S; Matsuda, T1
Endoh, M; Ishihata, A; Norota, I; Satoh, H; Shibasaki, T1
Beier, N; Haeusler, G; Harting, J; Jonas, R; Klockow, M; Lues, I1
Alpert, NR; Blanchard, EM; Hasenfuss, G; Holubarsch, CH; Just, H; Mulieri, LA1
Berger, C; Meyer, W; Scholz, H; Starbatty, J1
Alpert, NR; Blanchard, E; Hasenfuss, G; Holubarsch, C; Just, H; Mulieri, LA3
Allen, DG; Lee, JA; Ruegg, JC1
Alpert, NR; Blanchard, EM; Mulieri, LA1
Fujino, K; Solaro, RJ; Sperelakis, N1
Alpert, NR; Blanchard, EM1
Heiss, A; Honerjäger, P; Reiter, M; Schäfer-Korting, M; Schönsteiner, G1
Erdmann, E1
Holubarsch, C1
Piano, MR; Rosenblum, C; Schwertz, D; Solaro, RJ1
Azuma, M; Gando, S; Hattori, Y; Ishitani, T; Kanno, M; Kemmotsu, O; Tomita, F; Yokoshiki, H1
Bodi, A; Edes, I; Facsko, A; Kovacs, L; Kranias, EG; Kristof, E; Papp, JG; Papp, Z; Szigeti, G1
Harada, S; Hisatome, I; Miyagawa, S; Morikawa, K; Nakamura, Y; Ninomiya, H; Nishimura, M; Ogino, K; Otsuki, Y; Sawa, Y; Yamamoto, Y1
Nakata, TM; Shimada, K; Suzuki, K; Tanaka, R; Uemura, A1

Other Studies

22 other study(ies) available for pimobendan and isoproterenol

ArticleYear
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
    Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7

    Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding

2008
Phosphodiesterase inhibition and positive inotropy in failing human myocardium.
    Basic research in cardiology, 1992, Volume: 87 Suppl 1

    Topics: Benzimidazoles; Cyclic AMP; Dose-Response Relationship, Drug; Drug Interactions; Heart; Humans; Imidazoles; Isoenzymes; Isometric Contraction; Isoproterenol; Myocardial Contraction; Myocardium; Organ Culture Techniques; Oxindoles; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Piperazines; Pyridazines; Pyridones

1992
Effects of pimobendan, a cardiotonic and vasodilating agent with phosphodiesterase inhibiting properties, on isolated arteries and veins of rats.
    The Journal of pharmacology and experimental therapeutics, 1990, Volume: 252, Issue:3

    Topics: 1-Methyl-3-isobutylxanthine; Aminophylline; Animals; Arteries; Cardiotonic Agents; Colforsin; Drug Interactions; In Vitro Techniques; Isoproterenol; Male; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Phosphodiesterase Inhibitors; Pyridazines; Rats; Rats, Inbred Strains; Vasodilator Agents; Veins

1990
Different mechanisms involved in the positive inotropic effects of benzimidazole derivative UD-CG 115 BS (pimobendan) and its demethylated metabolite UD-CG 212 Cl in canine ventricular myocardium.
    Journal of cardiovascular pharmacology, 1991, Volume: 17, Issue:3

    Topics: Animals; Carbachol; Cardiotonic Agents; Cyclic AMP; Dogs; Dose-Response Relationship, Drug; Female; Guinea Pigs; In Vitro Techniques; Isoproterenol; Male; Myocardial Contraction; Propanolamines; Pyridazines; Vasodilator Agents

1991
The novel cardiotonic agent EMD 53 998 is a potent "calcium sensitizer".
    Journal of cardiovascular pharmacology, 1991, Volume: 18, Issue:1

    Topics: Adenosine Triphosphatases; Animals; Calcium; Carbachol; Cardiotonic Agents; Cattle; Cyclic AMP; Guinea Pigs; In Vitro Techniques; Isoenzymes; Isometric Contraction; Isoproterenol; Male; Myocardial Contraction; Myocardium; Myofibrils; Papillary Muscles; Phosphoric Diester Hydrolases; Pyridazines; Quinolines; Rats; Rats, Inbred Strains; Thiadiazines

1991
Modulation of myothermal economy of isometric force generation by positive inotropic interventions in the guinea pig myocardium.
    Cardioscience, 1990, Volume: 1, Issue:1

    Topics: Animals; Calcium; Cardiotonic Agents; Energy Metabolism; Guinea Pigs; Isoproterenol; Myocardial Contraction; Papillary Muscles; Pyridazines; Stimulation, Chemical

1990
Effects of the benzimidazole derivatives pimobendan and 2-(4-hydroxy-phenyl)-5-(5-methyl-3-oxo-4,5-dihydro-2H-6- pyridazinyl) benzimidazole . HCl on phosphodiesterase activity and force of contraction in guinea-pig hearts.
    Arzneimittel-Forschung, 1985, Volume: 35, Issue:11

    Topics: 1-Methyl-3-isobutylxanthine; Adenosine; Adenylyl Cyclases; Animals; Carbachol; Cardiotonic Agents; Female; Guinea Pigs; Heart Atria; Histamine; In Vitro Techniques; Isoproterenol; Male; Myocardial Contraction; Myocardium; Ouabain; Papillary Muscles; Phenylisopropyladenosine; Phosphodiesterase Inhibitors; Pyridazines

1985
Influence of the positive inotropic substance pimobendan (UD-CG 115 BS) on contractile economy of guinea pig papillary muscles.
    Journal of cardiovascular pharmacology, 1989, Volume: 14 Suppl 2

    Topics: Animals; Cardiotonic Agents; Guinea Pigs; Heart; Hot Temperature; Isoproterenol; Myocardial Contraction; Ouabain; Papillary Muscles; Pyridazines; Stimulation, Chemical

1989
Effects of pimobendan, a novel inotropic agent, on intracellular calcium and tension in isolated ferret ventricular muscle.
    Clinical science (London, England : 1979), 1989, Volume: 76, Issue:6

    Topics: Aequorin; Animals; Calcium; Cardiotonic Agents; Cyclic AMP; Ferrets; Heart Ventricles; In Vitro Techniques; Isoproterenol; Papillary Muscles; Pyridazines

1989
Energetic consequences of positive inotropic interventions in guinea pig papillary muscles.
    Progress in clinical and biological research, 1989, Volume: 315

    Topics: Animals; Body Temperature Regulation; Calcium; Cardiotonic Agents; Energy Metabolism; Guinea Pigs; In Vitro Techniques; Isoproterenol; Papillary Muscles; Pyridazines

1989
The effects of acute and chronic inotropic interventions on tension independent heat of rabbit papillary muscle.
    Basic research in cardiology, 1987, Volume: 82 Suppl 2

    Topics: Animals; Cardiomegaly; Cardiotonic Agents; Heart; In Vitro Techniques; Isoproterenol; Myocardial Contraction; Pyridazines; Rabbits; Thyrotoxicosis

1987
Differential effects of d- and l-pimobendan on cardiac myofilament calcium sensitivity.
    The Journal of pharmacology and experimental therapeutics, 1988, Volume: 247, Issue:2

    Topics: Actin Cytoskeleton; Action Potentials; Animals; Calcium; Cytoskeleton; Dogs; Electrophysiology; Guinea Pigs; Heart; Isomerism; Isoproterenol; Kinetics; Propranolol; Pyridazines

1988
The effects of isoproterenol, UDCG 115, and caffeine on the heart related to excitation-contraction coupling in heart muscle.
    Canadian journal of physiology and pharmacology, 1987, Volume: 65, Issue:4

    Topics: Animals; Caffeine; Calcium; Hot Temperature; Isoproterenol; Kinetics; Male; Myocardial Contraction; Pyridazines; Rabbits; Stimulation, Chemical; Thermodynamics

1987
Energetic aspects of inotropic interventions in rat myocardium.
    Basic research in cardiology, 1987, Volume: 82 Suppl 2

    Topics: Animals; Calorimetry; Cardiotonic Agents; Heart; Heart Ventricles; In Vitro Techniques; Isoproterenol; Myocardial Contraction; Pyridazines; Rats; Rats, Inbred WKY; Thermodynamics; Ventricular Function

1987
UD-CG 115--a cardiotonic pyridazinone which elevates cyclic AMP and prolongs the action potential in guinea-pig papillary muscle.
    Naunyn-Schmiedeberg's archives of pharmacology, 1984, Volume: 325, Issue:3

    Topics: Action Potentials; Animals; Carbachol; Cardiotonic Agents; Cimetidine; Cyclic AMP; Female; Guinea Pigs; Histamine; In Vitro Techniques; Isoproterenol; Male; Myocardial Contraction; Papillary Muscles; Phosphodiesterase Inhibitors; Propranolol; Pyridazines; Reserpine; Sodium-Potassium-Exchanging ATPase; Stimulation, Chemical

1984
The effect of positive inotropes on the failing human myocardium.
    Cardiology, 1997, Volume: 88 Suppl 2

    Topics: 1-Methyl-3-isobutylxanthine; Adrenergic beta-Agonists; Calcium; Cardiotonic Agents; Dobutamine; Heart Failure; Humans; In Vitro Techniques; Isoproterenol; Milrinone; Myocardial Contraction; Papillary Muscles; Phosphodiesterase Inhibitors; Pyridazines; Pyridones

1997
New inotropic concepts: rationale for and differences between calcium sensitizers and phosphodiesterase inhibitors.
    Cardiology, 1997, Volume: 88 Suppl 2

    Topics: Animals; Calcium; Cardiotonic Agents; Deoxyepinephrine; Energy Metabolism; Guinea Pigs; Heart Failure; Humans; Imidazoles; In Vitro Techniques; Isoproterenol; Myocardial Contraction; Myocardium; Papillary Muscles; Phosphodiesterase Inhibitors; Pyridazines; Pyridones; Quinolines; Thiadiazines

1997
Calcium sensitivity and the effect of the calcium sensitizing drug pimobendan in the alcoholic isolated rat atrium.
    Journal of cardiovascular pharmacology, 1999, Volume: 33, Issue:2

    Topics: Alcohol Drinking; Animals; Atrial Fibrillation; Calcium; Cardiotonic Agents; Dose-Response Relationship, Drug; Heart Atria; In Vitro Techniques; Isoproterenol; Male; Pyridazines; Rats; Rats, Sprague-Dawley; Time Factors

1999
Cardiac profile of EGIS-9377, a novel cardiotonic agent as a Ca2+ sensitizer with bradycardiac activity.
    Naunyn-Schmiedeberg's archives of pharmacology, 1999, Volume: 360, Issue:5

    Topics: Animals; Calcium; Cardiotonic Agents; Depression, Chemical; Dose-Response Relationship, Drug; Drug Interactions; Electric Stimulation; Female; Guinea Pigs; Heart; Heart Rate; Heart Ventricles; In Vitro Techniques; Isoproterenol; Male; Morpholines; Myocardial Contraction; Papillary Muscles; Pyridazines; Pyrimidines; Time Factors; Ventricular Function

1999
Cardiac responses to calcium sensitizers and isoproterenol in intact guinea pig hearts. Effects on cyclic AMP levels, protein phosphorylation, myoplasmic calcium concentration, and left ventricular function.
    Annals of the New York Academy of Sciences, 1998, Sep-16, Volume: 853

    Topics: Animals; Calcium; Cardiotonic Agents; Cyclic AMP; Guinea Pigs; Heart; Hydrazones; Isoproterenol; Muscle Proteins; Myocardium; Phosphorylation; Pyridazines; Quinolines; Simendan; Thiadiazines; Ventricular Function, Left

1998
Adipose stem cell sheets improved cardiac function in the rat myocardial infarction, but did not alter cardiac contractile responses to β-adrenergic stimulation.
    Biomedical research (Tokyo, Japan), 2015, Volume: 36, Issue:1

    Topics: Adipocytes; Animals; Atrial Natriuretic Factor; Atrial Remodeling; Bucladesine; Cardiomegaly; Cell Differentiation; Diastole; Fibroblast Growth Factors; Hepatocyte Growth Factor; Isoproterenol; Male; Myoblasts, Skeletal; Myocardial Contraction; Myocardial Infarction; Myocardium; Organ Culture Techniques; Paracrine Communication; Pyridazines; Rats; Rats, Inbred Lew; Stem Cell Transplantation; Stem Cells; Systole; Vascular Endothelial Growth Factor A

2015
Contrasting Effects of Inhibition of Phosphodiesterase 3 and 5 on Cardiac Function and Interstitial Fibrosis in Rats With Isoproterenol-Induced Cardiac Dysfunction.
    Journal of cardiovascular pharmacology, 2019, Volume: 73, Issue:3

    Topics: Animals; Arrhythmias, Cardiac; Collagen Type I; Collagen Type III; Disease Models, Animal; Fibrosis; Isoproterenol; Male; Myocardium; Phosphodiesterase 3 Inhibitors; Phosphodiesterase 5 Inhibitors; Pyridazines; Rats, Wistar; Risk Assessment; Sildenafil Citrate; Ventricular Dysfunction, Left; Ventricular Function, Left; Ventricular Remodeling

2019
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