pimaric-acid and podocarpic-acid

pimaric-acid has been researched along with podocarpic-acid* in 1 studies

Other Studies

1 other study(ies) available for pimaric-acid and podocarpic-acid

Article	Year
Design, synthesis and characterization of podocarpate derivatives as openers of BK channels. Bioorganic & medicinal chemistry letters, 2008, Oct-01, Volume: 18, Issue:19 We found that the podocarpic acid structure provides a new scaffold for chemical modulators of large-conductance calcium-activated K(+) channels (BK channels). Structure-activity analysis indicates the importance of both the arrangement (i.e., location and orientation) of the carboxylic acid functionality of ring A and the hydrophobic region of ring C for expression of BK channel-opening activity. Topics: Abietanes; Carboxylic Acids; Combinatorial Chemistry Techniques; Diterpenes; Ion Channel Gating; Large-Conductance Calcium-Activated Potassium Channels; Models, Molecular; Molecular Structure; Patch-Clamp Techniques; Structure-Activity Relationship	2008

Article

Year

Design, synthesis and characterization of podocarpate derivatives as openers of BK channels.

Bioorganic & medicinal chemistry letters, 2008, Oct-01, Volume: 18, Issue:19

We found that the podocarpic acid structure provides a new scaffold for chemical modulators of large-conductance calcium-activated K(+) channels (BK channels). Structure-activity analysis indicates the importance of both the arrangement (i.e., location and orientation) of the carboxylic acid functionality of ring A and the hydrophobic region of ring C for expression of BK channel-opening activity.

Topics: Abietanes; Carboxylic Acids; Combinatorial Chemistry Techniques; Diterpenes; Ion Channel Gating; Large-Conductance Calcium-Activated Potassium Channels; Models, Molecular; Molecular Structure; Patch-Clamp Techniques; Structure-Activity Relationship

2008