Compounds > pimagedine

pimagedine and methotrexate

pimagedine has been researched along with methotrexate in 6 studies

Research

Studies (6)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's6 (100.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A1
Bellaguarda, EA; Braga-Neto, MB; Brito, GA; Freire, RS; Gomes, AS; Leitão, RF; Lima-Júnior, RC; Oriá, RB; Ribeiro, RA; Silva, JV; Siqueira, FJ; Vale, ML1
Abdelrahman, AM; Amin, EF; Goma, W; Hafez, HM; Ibrahim, MA; Ibrahim, SA1
Abraham, P; Kota, R; Natarajan, K; Selvakumar, D1
Abraham, P; Kota, R; Natarajan, K1
Abraham, P; Isaac, B; Kota, R; Natarajan, K1

Other Studies

6 other study(ies) available for pimagedine and methotrexate

ArticleYear
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
    Chemical research in toxicology, 2010, Volume: 23, Issue:1

    Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship

2010
Role of inducible nitric oxide synthase pathway on methotrexate-induced intestinal mucositis in rodents.
    BMC gastroenterology, 2011, Aug-16, Volume: 11

    Topics: Animals; Cell Death; Cell Proliferation; Enzyme Inhibitors; Guanidines; Immunohistochemistry; In Situ Nick-End Labeling; Injections, Intraperitoneal; Ki-67 Antigen; Male; Methotrexate; Mice; Mice, Knockout; Mucositis; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase Type II; Peroxidase; Rats; Rats, Wistar; Tyrosine

2011
Potential protective effect of etanercept and aminoguanidine in methotrexate-induced hepatotoxicity and nephrotoxicity in rats.
    European journal of pharmacology, 2015, Dec-05, Volume: 768

    Topics: Animals; Biomarkers; Caspase 3; Cytoprotection; Etanercept; Guanidines; Kidney; Liver; Male; Methotrexate; Nitric Oxide Synthase Type II; Oxidative Stress; Rats; Tumor Necrosis Factor-alpha

2015
Aminoguanidine pretreatment prevents methotrexate-induced small intestinal injury in the rat by attenuating nitrosative stress and restoring the activities of vital mitochondrial enzymes.
    Journal of basic and clinical physiology and pharmacology, 2017, May-01, Volume: 28, Issue:3

    Topics: Animals; Antioxidants; Citric Acid Cycle; Electron Transport; Guanidines; Intestine, Small; Male; Methotrexate; Mitochondria; Nitric Oxide; Nitrosative Stress; Oxidative Stress; Rats; Rats, Wistar

2017
Activation of the mitochondrial apoptotic pathway contributes to methotrexate-induced small intestinal injury in rats.
    Cell biochemistry and function, 2017, Volume: 35, Issue:7

    Topics: Animals; Apoptosis; Caspase 3; Caspase 9; Cytochromes c; DNA Fragmentation; Guanidines; Intestine, Small; Male; Methotrexate; Microscopy, Fluorescence; Mitochondria; Nitric Oxide; Nitric Oxide Synthase Type II; Poly (ADP-Ribose) Polymerase-1; Protective Agents; Rats; Rats, Wistar

2017
NF-κB-iNOS-COX2-TNF α inflammatory signaling pathway plays an important role in methotrexate induced small intestinal injury in rats.
    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 2018, Volume: 118

    Topics: Animals; Antimetabolites, Antineoplastic; Cyclooxygenase 2; Guanidines; Heme Oxygenase-1; HSP70 Heat-Shock Proteins; Inflammation; Inflammation Mediators; Intestine, Small; Male; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Methotrexate; NF-kappa B; Nitric Oxide Synthase Type II; Phospholipases A2; Rats, Wistar; RNA, Messenger; Signal Transduction; Tumor Necrosis Factor-alpha; Up-Regulation

2018