Page last updated: 2024-08-16

pilsicainide and lidocaine

pilsicainide has been researched along with lidocaine in 200 studies

Research

Studies (200)

TimeframeStudies, this research(%)All Research%
pre-199015 (7.50)18.7374
1990's37 (18.50)18.2507
2000's104 (52.00)29.6817
2010's37 (18.50)24.3611
2020's7 (3.50)2.80

Authors

AuthorsStudies
Aisaka, K; Hayashimatsu, M; Miyano, S; Morita, M; Noguchi, T; Satoh, F; Shima, K; Sumoto, K1
Bianucci, AM; Calderone, V; Coi, A; Massarelli, I; Testai, L1
Sen, S; Sinha, N1
Arita, M; Kiyosue, T; Sato, T; Wu, B1
Kato, R; Koide, M; Miyahara, T; Sotobata, I; Toyama, J; Ukai, M; Yasui, S; Yokota, M1
Hattori, Y; Inomata, N1
Handa, S; Ogawa, S; Okada, Y; Sadanaga, T1
Ikeda, N; Kamiya, K1
Hashimoto, H; Nakashima, M; Satoh, N1
Akaike, N; Inomata, N; Ishihara, T3
Goto, T; Hayashi, H; Isikawa, S; Ito, A; Kato, R; Sotobata, I; Suzuki, M; Terazawa, T1
Hara, H; Hashimoto, N; Ishida, Y; Nakamura, S; Ohta, H; Sasaki, T; Satoh, S; Takabatake, T; Ushiogi, Y; Yamamoto, Y1
Hashimoto, K; Ishii, M; Komori, S; Mitsuhashi, H1
Inomata, N; Ishihara, T1
Aisaka, K; Hattori, Y; Hidaka, T; Ishihara, T; Satoh, F1
Endoh, S; Hangai, K; Keitoku, M; Kinoshita, H; Morita, M; Ohtsuka, K; Satoh, S; Sekiguchi, N; Takishima, T; Watanabe, J1
Hanaki, Y; Hieda, N; Ogawa, T; Ozawa, T; Sugiyama, S; Taki, K1
Hattori, Y; Ishihara, T; Kodama, I; Kusunoki, T; Toyama, J; Yamada, K1
Hashimoto, Y; Hatta, M; Hattori, Y; Hirotsu, I; Ishihara, T; Kihara, T; Kitakaze, Y; Miyata, T; Nakamura, S; Takahama, K1
Hatta, M; Hattori, Y; Hirose, N; Hirotsu, I; Ishihara, T; Kihara, T; Satoh, F1
Aisaka, K; Hattori, Y; Hidaka, T; Inomata, N; Ishihara, T; Satoh, F1
Aisaka, K; Hamasaki, S; Hidaka, T; Inomata, N; Ishihara, T; Morita, M1
Aisaka, K; Hamasaki, S; Hidaka, T; Ishihara, T; Morita, M; Toyama, J; Yamada, K1
Akaike, N; Yatani, A1
Asayama, J; Inoue, D; Inoue, M; Ishibashi, K; Nakagawa, M; Sakai, R; Shirayama, T; Yamahara, Y1
Ogawa, S; Sadanaga, T1
Ajiki, K; Inoue, H; Murakawa, Y; Nakajima, T; Ohkawa, S; Oikawa, N; Sugimoto, T; Usui, M; Yamashita, T1
Higuchi, M; Itomine, T; Matsuzaki, T; Nakasone, J; Noguchi, K; Ojiri, Y; Sakanashi, M; Shiroma, N1
Asayama, J; Inoue, D; Inoue, M; Ishibashi, K; Nakagawa, M; Omori, I; Sakai, R; Shirayama, T; Yamahara, Y1
Liu, JX; Ohtsuka, Y; Sakai, Y; Takeo, S; Tanonaka, K1
Akaishi, M; Handa, S; Iwanaga, S; Ogawa, S; Okada, Y; Sadanaga, T; Tsutsumi, N; Yoshikawa, T1
Asayama, J; Inoue, D; Inoue, M; Ishibashi, K; Nakagawa, M; Omori, I; Sakai, R; Yamahara, Y1
Akaike, N; Inomata, N; Ishihara, T; Ohno, T1
Hatakeyama, N; Inoko, M; Kihara, Y; Momose, Y; Sasayama, S1
Nakata, Y; Nakazato, K; Nakazato, Y; Ogura, S; Sumiyoshi, M; Tokano, T; Yamagami, S; Yamaguchi, H; Yasuda, M1
Atarashi, H; Hayakawa, H; Hiejima, K; Inoue, H1
Fujiki, A; Inoue, H; Tani, M; Yoshida, S1
Baba, S; Funakoshi, M; Ishide, N; Iwabuchi, K; Katoh, H; Keitoku, M; Miura, M; Satoh, S; Shinozaki, T; Shirato, K; Suzuki, S; Takeuchi, M; Watanabe, J1
Fujiki, A; Hayashi, H; Inoue, H; Tani, M; Usui, M1
Atarashi, H; Hayakawa, H; Ino, T; Kuruma, A; Onodera, T; Saitoh, H1
Annoura, M; Arakawa, K; Ideishi, M; Kumagai, K; Matsuo, K1
Arita, M; Sato, T; Shigematsu, S1
Gomi, A; Kohno, K; Nagano, N; Nakatani, H; Shimabukuro, T; Suda, Y; Takeuchi, Y1
Fukui, E; Hayami, N; Inoue, M; Murakawa, Y; Omata, M; Sezaki, K; Yamashita, T1
Ito, H; Nakamura, W; Segawa, K; Tanaka, S; Yoshimoto, N1
Iwasa, A; Matsunaga, T; Okumura, K; Tabuchi, T; Tayama, S; Tsuchiya, T; Tsunoda, R; Yasue, H1
Kanki, H; Mitamura, H; Ogawa, S; Sato, T; Shinagawa, K; Sueyoshi, K; Takatsuki, S1
Asano, Y; Fukunami, M; Hoki, N; Hori, M; Kumagai, K; Ogita, H; Sanada, S; Shimonagata, T; Yamada, T1
Hiraoka, M; Inoue, H; Kasanuki, H; Kato, T; Kodama, I; Mitamura, H; Ogawa, S; Sugimoto, T1
Fujiki, A; Hayashi, H; Inoue, H; Mizumaki, K; Nagasawa, H; Usui, M1
Matsuo, S; Ozeki, S; Utsunomiya, T; Yano, K1
Ashihara, T; Nakazawa, K; Namba, T; Ohe, T1
Kanki, H; Mitamura, H; Ogawa, S; Sato, T; Shinagawa, K; Takatsuki, S; Takeshita, A1
Arita, M; Kaku, T; Kitabatake, A; Makita, N; Ono, K1
Hashiguchi, M; Kasanuki, H; Rikihisa, T; Shiga, T; Urae, A1
Akkaya, V; Atilgan, D; Demirel, S; Güven, O; Korkut, F; Kudat, H; Ozcan, M; Sözen, AB; Tükek, T1
Izumi, T; Kitano, Y; Moriguchi, M; Niwano, S1
Hayashi, Y; Hidaka, T; Inomata, N; Inoue, T; Komoriya, K1
Aonuma, K; Azegami, K; Igawa, M; Nishizaki, M; Okishige, K; Yamawaki, N1
Abe, T; Fuse, K; Murooka, H; Saigawa, T; Susa, R; Toeda, T; Yamaguchi, Y1
Aye, NN; Hashimoto, K; Miyamoto, S; Teramatsu, T; Zhu, B1
Abe, H; Kohshi, K; Nagatomo, T; Nakashima, Y; Numata, T2
Kawano, Y; Mineda, Y; Nakata, Y; Nakazato, K; Nakazato, Y; Sekita, G; Sumiyoshi, M; Tokano, T; Yamashita, H; Yasuda, M1
Abe, H; Hiraki, T; Ikeda, H; Imaizumi, T; Kumagai, K; Nakashima, H; Nakashima, Y; Oginosawa, Y; Saku, K1
Emori, T; Hisamatsu, K; Kusano, KF; Matsubara, H; Morita, H; Nagase, S; Nakamura, K; Ohe, T; Takenaka, S1
Azegami, K; Hiejima, K; Hirao, K; Horikawa, T; Kawabata, M; Motokawa, K; Suzuki, F; Suzuki, K1
Fujii, Z; Fujimoto, K; Kawata, Y; Matsumoto, M; Matsuzaki, M; Minami, M; Nawata, C; Sakumura, T1
Conway, DS; Lip, GY1
Fujito, H; Mori, M; Saita, T1
Kimura, M; Komatsu, T; Nakamura, S; Okumura, K; Owada, S; Tomita, H; Yomogida, K1
Nattel, S1
Hara, M; Kanki, H; Kurita, Y; Mitamura, H; Miyoshi, S; Ogawa, S; Sato, T; Shinagawa, K; Takeshita, A1
Nakata, Y; Nakazato, Y1
Aiba, T; Kamakura, S; Kurita, T; Shimizu, W1
Aizawa, Y; Chinushi, M; Chinushi, Y; Toida, T1
Abe, T; Fu, LT; Iinuma, H; Kirigaya, H; Nakada, M; Sagara, K; Sahara, M; Watanabe, H; Yamashita, T1
Furuta, I; Kitahashi, T1
Doi, A; Takagi, M; Takeuchi, K; Yoshikawa, J1
Fujiki, A; Inoue, H; Mizumaki, K; Nishida, K; Sakabe, M; Sugao, M; Tsuneda, T1
Imai, H; Matoba, Y; Nakagawa, M; Shiraishi, H; Shirayama, T; Yoshida, S1
Hara, H; Ikeda-Murakami, K; Inuo, K; Izumi, T; Kojima, J; Niwano, S; Saito, J; Yoshida, T2
Ashihara, T; Hirai, H; Ikeda, T; Kawase, A; Kubota, T; Nakazawa, K; Namba, T; Sugi, K1
Katoh, T; Ono, T; Sutovsky, I; Takano, T; Takayama, H1
Emori, T; Fukushima-Kusano, K; Kakishita, M; Kobayashi, M; Matsubara, H; Morita, H; Nagase, S; Nakamura, K; Ohe, T; Takenaka-Morita, S1
Ikeda, K; Inuo, K; Izumi, T; Kojima, J; Moriguchi, M; Niwano, S; Saito, J1
Aonuma, K; Doi, H; Hosokawa, N; Kato, K; Kubota, S; Nakamura, H; Nakao, M; Nitta, J; Nogami, A; Sagai, H; Sugiyasu, A; Tamaki, T; Yamauchi, Y; Yokoyama, K; Yumoto, K1
Kubota, I; Nagai, S; Takeishi, Y1
Kanmatsuse, K; Kasamaki, Y; Kofune, T; Masaki, R; Ohkubo, K; Okumura, Y; Oshikawa, N; Ozawa, Y; Saito, S; Watanabe, I; Yamada, T1
Furuhashi, M; Hoshikawa, K; Sakai, E; Satoh, S; Shimamoto, K; Tsuchihashi, K; Uno, K1
Hirano, Y; Hiraoka, M; Kawano, S; Orikabe, M; Wu, LM1
Ebina, T; Ishikawa, T; Kimura, K; Kobayashi, T; Matsumoto, K; Matsushita, K; Mochida, Y; Nakagawa, T; Nakazawa, I; Ohkusu, Y; Sumita, S; Uchino, K; Umemura, S; Yamakawa, Y2
Banba, K; Emori, T; Hina, K; Kita, T; Kusano, KF; Matsubara, H; Morita, H; Morita, ST; Nagase, S; Nakamura, K; Nishii, N; Ohe, T; Tani, Y; Watanabe, A1
Ashikaga, K; Higuma, T; Iwasa, A; Kimura, M; Kobayashi, T; Motomura, S; Okumura, K; Owada, S; Sasaki, S1
Kanmatsuse, K; Kofune, T; Masaki, R; Okubo, K; Okumura, Y; Oshikawa, N; Ozawa, Y; Saito, S; Sugimura, H; Takagi, Y; Wakita, R; Watanabe, I; Yamada, T1
Arai, M; Kishi, R; Miyake, F; Nakazawa, K; Osada, K; Ryu, S; Takagi, A1
Ando, A; Hirai, M; Inden, Y; Isobe, S; Murohara, T; Nonokawa, M; Okada, M; Suzuki, A; Takada, Y; Tomita, Y1
Dohi, S; Iida, H; Oda, A; Osawa, Y; Tanahashi, S1
Esato, M; Inoue, N; Kakugawa, H; Kametani, R; Kanemoto, M; Matsuzaki, M; Sawa, A; Shimizu, A; Ueyama, T; Yamagata, T; Yoshiga, Y1
Imaki, R; Inuo, K; Izumi, T; Morohoshi, Y; Nakayama, S; Niwano, S; Yuge, M1
Fujimura, A; Sakamoto, K; Shiga, T; Tsuruoka, S; Wakaumi, M1
Kumagai, K; Nakashima, H; Noguchi, H; Ogawa, M; Saku, K; Tojo, H; Yasuda, T; Zhang, B1
Funada, A; Horita, Y; Kaku, B; Kanaya, H; Kitajima, S; Matsumura, M; Satoh, T; Uno, Y; Yamazaki, T1
Hiasa, G; Nishimura, K; Okayama, H; Sumimoto, T1
Hashimoto, K; Honsho, S; Nakamura, Y; Sugiyama, A; Takahara, A1
Aizawa, T; Fu, LT; Goda, A; Itoh, H; Kato, T; Kirigaya, H; Koike, A; Sagara, K; Yamashita, T1
Fukumoto, K; Kamakura, S; Kusumoto, M; Matsumoto, K; Tanemura, M; Tsuchishita, Y; Ueno, K1
Higa, N; Kosugi, T; Shimabukuro, M; Sunagawa, M; Takasu, N; Yamakawa, M1
Azegami, K; Hirao, K; Isobe, M; Okishige, K; Otomo, K; Yamamoto, N1
Kumagai, K; Miura, S; Nakashima, H; Noguchi, H; Ogawa, M; Saku, K; Tojo, H; Yasuda, T; Zhang, B1
Aizawa, Y; Chinushi, M; Hirono, T; Komura, S; Sugiura, H1
Echizen, H; Kishi, R; Kobayashi, S; Masuhara, K; Matsumoto, N; Mihara, K; Miyake, F; Nakazawa, K; Ogawa, R; Takagi, A; Takahashi, H1
Mato, T; Moriwaki, R; Nakata, K; Takenouchi, S; Tsutsumi, H; Yamaguchi, A1
Fujimura, A; Ioka, T; Ookami, H; Sakamoto, K; Tsuruoka, S; Wakaumi, M1
Aihara, N; Kamakura, S; Kurita, T; Nagai, T; Noda, T; Satomi, K; Shimizu, W; Suyama, K1
Aiba, T; Hidaka, I; Inagaki, M; Kamiya, A; Noda, T; Shimizu, W; Sugimachi, M; Sunagawa, K; Uemura, K; Zheng, C1
Atarashi, H; Fukunami, M; Inoue, H; Kumagai, K; Okishige, K1
Horiuchi, D; Komatsu, T; Nakamura, M; Okumura, K; Sato, Y; Tachibana, H1
Abe, A; Ikeda, T; Ishiguro, H; Mera, H; Nakamura, K; Yoshino, H; Yotsukura, M; Yusu, S1
Arakaki, T; Isomoto, S; Kawakami, A; Ono, K; Yamashita, S; Yano, K1
Araki, S; Ogawa, H; Sadanaga, T; Tanaka, Y1
Kumagai, K; Matsumoto, N; Nakashima, H; Noguchi, H; Ogawa, M; Saku, K; Tojo, H; Yasuda, T1
Katoh, T; Kobayashi, Y; Morita, N; Ohara, T; Takano, T; Takayama, H; Yodogawa, K1
Baltes, E; Strolin-Benedetti, M; Whomsley, R1
Esato, M; Kametani, R; Kanemoto, M; Matsuzaki, M; Ohmura, M; Sawa, A; Shimizu, A; Sugi, N; Suzuki, S; Ueyama, T; Yamagata, T; Yoshiga, Y1
Aizawa, Y; Chinushi, M; Furushima, H; Izumi, D; Watanabe, H1
Morita, H; Morita, ST; Wu, J; Zipes, DP2
Deschênes, I; Laurita, KR1
Fujita, S; Ishikawa, Y; Kishi, R; Matsuda, H; Miyake, F; Nakazawa, K; Osada, K; Ryu, S; Sakurai, T; Takagi, A1
Saikawa, T; Shinohara, T; Takahashi, N; Yoshimatsu, H1
Aizawa, Y; Chinushi, M; Furushima, H; Izumi, D; Komura, S; Tanabe, Y; Washizuka, T1
Endo, N; Hirosaka, A; Miura, E; Niitsuma, T; Owada, K; Sekiguchi, Y; Takeda, H; Tamagawa, K; Tsuburaya, R; Yoshisato, T1
Banba, K; Kusano, KF; Miura, D; Morita, H; Nagase, S; Nakamura, K; Nishii, N; Ohe, T; Tada, T; Watanabe, A1
Hamazaki, M; Hirose, M; Ohkubo, Y; Sekido, T; Takano, M; Yamada, M1
Esato, M; Matsuzaki, M; Sawa, A; Shimizu, A; Sugi, N; Suzuki, S; Ueyama, T; Yoshiga, Y1
Furukawa, Y; Hiromoto, K; Kanemori, T; Masuyama, T; Mine, T; Ohyanagi, M; Oka, K; Shimizu, H1
Furukawa, T; Hachiya, H; Higuchi, K; Hirao, K; Isobe, M; Kawabata, M; Okada, H; Sasaki, T1
Madias, JE1
Banba, K; Hiramatsu, S; Kusano, KF; Morita, H; Nagase, S; Nakamura, K; Nishii, N; Ohe, T; Sakuragi, S; Watanabe, A1
Aoyama, H; Enomoto, M; Hirayama, A; Imai, S; Kushiro, T; Saito, F; Takase, H; Yagi, H; Yamaji, S; Yokoyama, K1
Hiramatsu, S; Karshima, E; Maruyama, T; Odashiro, K1
Hikiji, W; Ikeda, N; Ishida, T; Kudo, K; Nishida, N; Tsuji, A; Usumoto, Y1
Ashino, S; Hirayama, A; Kofune, M; Kofune, T; Nakai, T; Ohkubo, K; Okumura, Y; Watanabe, I1
Komatsu, T; Kunigida, F; Nakamura, M; Ohshima, K; Orii, M; Ozawa, M; Sato, Y; Tachibana, H1
Mori, K; Nagata, M; Oe, K1
Horiuchi, D; Iwasa, A; Kimura, M; Okumura, K; Owada, S; Sasaki, K; Sasaki, S1
Harada, M; Honjo, H; Ishiguro, YS; Kamiya, K; Kodama, I; Morishima, M; Nakagawa, H; Okuno, Y; Opthof, T; Sakuma, I; Suzuki, T; Takanari, H; Yamazaki, M1
Dosdall, DJ1
Fujimoto, N; Kasai, A; Kawasaki, A; Omichi, C1
Hong, JH; Jang, IJ; Kim, BH; Kim, JR; Kim, JW; Kim, KP; Lim, KS; Shin, SG; Tanaka, T; Yu, KS1
Fujiki, A; Fukaya, H; Hatakeyama, Y; Izumi, T; Kiryu, M; Kurokawa, S; Niwano, H; Niwano, S; Sasaki, T1
Aizawa, Y; Chinushi, M; Furushima, H; Izumi, D; Tagawa, M1
Iwasaki, H; Nagai, T; Nakamura, Y; Satoh, Y; Shinkai, N; Sugiyama, A; Takahara, A1
Doi, A; Maeda, K; Nakagawa, E; Shimeno, K; Takagi, M; Tatsumi, H; Yoshiyama, M1
Enjoji, Y; Funatsu, A; Kobayashi, T; Mizobuchi, M; Muranishi, H; Nakamura, S; Utsunomiya, M1
Doi, A; Maeda, K; Shimeno, K; Takagi, M; Tatsumi, H; Yoshiyama, M1
Echizen, H; Kishi, R; Kobayashi, S; Masuhara, K; Matsumoto, N; Miyake, F; Nakazawa, K; Ogawa, R; Sakaue, I; Takagi, A; Takahashi, H1
Plosker, GL1
Doi, M; Matsuzaki, M; Ohmiya, T; Ohno, M; Shimizu, A; Sugi, N; Ueyama, T; Yoshida, M; Yoshiga, Y1
Adachi, T; Hisada, T; Ikewaki, K; Miyagawa, T; Ogata, K; Ohsuzu, F; Sakai, M; Sakurai, Y; Tsujimoto, T; Yakushiji, T1
Bruno, C; Conte Camerino, D; Costanza, T; Desaphy, JF; Dipalma, A; Franchini, C; George, A; Lentini, G1
Imai, T; Kajimoto, K; Kasanuki, H; Minami, Y1
Doi, S; Hata, A; Hinokiyama, H; Ibata, T; Iijima, H; Komuro, R; Mito, S; Nakashita, C; Sato, M; Shiki, S1
Ashino, S; Hirayama, A; Kasamaki, Y; Kofune, M; Kunimoto, S; Nagashima, K; Nakai, T; Ohkubo, K; Okumura, Y; Watanabe, I1
Fukuda, K; Kondo, M; Kumagai, K; Miura, M; Nakano, M; Shimokawa, H; Shirato, K; Wakayama, Y; Watanabe, J; Yagi, T1
Matsuzaki, M; Murata, K; Nose, Y; Tanaka, T; Ueyama, T; Wada, Y1
Kaneko, Y; Kato, T; Kurabayashi, M; Nakajima, T1
Fujiwara, R; Fukuzawa, K; Hirata, K; Imamura, K; Itoh, M; Kanda, G; Kumagai, H; Suzuki, A; Takami, K; Takami, M; Takei, A; Tanaka, S; Yoshida, A1
Hagiwara, M; Namekata, I; Takahara, A; Takeda, K; Tanaka, H; Tsuneoka, Y1
Hirayama, A; Kofune, M; Mano, H; Nagashima, K; Ohkubo, K; Okumura, Y; Sonoda, K; Watanabe, I1
Adachi-Akahane, S; Ikeda, T; Kitahara, K; Nakamura, Y; Sugiyama, A; Takahara, A; Tanaka, H; Tsuneoka, Y; Yamazaki, H; Yamazaki, J1
Hagiwara, M; Nozaki, S; Sugiyama, A; Suzuki, S; Takahara, A1
Fukami, N; Nakamura, K1
Du, H; Li, J; Lin, Y; Liu, W; Qiu, Q; Suo, W; Wei, Y; Wu, W; Yang, K; Zhang, Y; Zhao, G; Zheng, Y; Zhou, Z1
Hirao, K; Obayashi, T; Yagishita, A; Yamauchi, Y1
Hashiguchi, M; Mochizuki, M; Nakamura, K; Shiga, T; Shimizu, M; Tamura, HO1
Aiba, T; Ishibashi, K; Kamakura, S; Kamakura, T; Kimura, T; Kusano, K; Makiyama, T; Miyamoto, K; Nakajima, I; Noda, T; Ogawa, H; Okamura, H; Shimizu, W; Takaki, H; Wada, M; Yasuda, S1
Aonuma, K; Sekiguchi, Y; Tada, H; Yamasaki, H1
Ai, T; Horie, M; Itoh, H; Makiyama, T; Shimizu, A; Turker, I; Ueyama, T; Vatta, M1
Ando, K; Cao, X; Izumi-Nakaseko, H; Matsukura, S; Nakamura, Y; Sugiyama, A; Wada, T; Yamazaki, H1
Doi, A; Hayashi, Y; Kakihara, J; Takagi, M; Tatsumi, H; Yoshiyama, M1
Bahrudin, U; Hisatome, I; Inoue, M; Itoh, T; Kato, M; Kawata, Y; Kita, A; Li, P; Morimoto, Y; Murakami, T; Ninomiya, H; Nishio, K; Obara, Y; Saeki, Y; Sakane, I; Sugiyama, R; Tanaka, K; Tsujitani, S; Unno, M; Yamaguchi, H1
Ito, H; Kawada, S; Miyamoto, M; Morimoto, Y; Morita, H; Nakagawa, K; Nishii, N; Tachibana, M; Ueoka, A; Watanabe, A1
Fukasawa, M; Fuke, C; Kawakami, Y; Miyazaki, T; Ninomiya, K1
Arakawa, S; Doi, Y; Etoh, R; Fukae, S; Ishimatsu, T; Kawano, H; Maemura, K; Tomichi, Y1
Fujii, K1
Aiba, T; Inoue, YY; Ishibashi, K; Kamakura, S; Kamakura, T; Kusano, K; Miyamoto, K; Nagase, S; Nagayama, T; Noda, T; Noguchi, T; Shimizu, W; Sugimachi, M; Takaki, H; Wada, M; Yasuda, S1
Hasebe, H; Kurebayashi, N; Murakoshi, N; Yokoya, T1
Hamaguchi, S; Hiiro, H; Irie, M; Namekata, I; Tanaka, H1
Kamono, M; Komatsu, R; Miyazaki, K; Onuma, Y1
Chen, SA; Chen, YC; Chen, YJ; Higa, S; Lin, FZ; Lin, YK; Liu, CM; Lu, YY; Wu, CI1
Iwamoto, Y; Kobayashi, T; Kojima, T; Masutani, S; Mori, H; Muraji, S; Nabeshima, T; Sumitomo, N; Taki, M; Toda, K; Yoshiba, S1
Fujikawa, H; Hirano, Y; Shibazaki, S1
Deguchi, N; Hamaguchi, S; Hashimoto, T; Hiiro, H; Kaneko, M; Mizoguchi, M; Namekata, I; Takahashi, Y; Tanaka, H1
Ichikawa, T; Kishimoto, T; Kume, M; Oya, S; Sakurai, S; Shiraishi, K; Takitani, Y; Yamada, H1

Reviews

7 review(s) available for pilsicainide and lidocaine

ArticleYear
Profiles of aprindine, cibenzoline, pilsicainide and pirmenol in the framework of the Sicilian Gambit. The Guideline Committee for Clinical Use of Antiarrhythmic Drugs in Japan (Working Group of Arrhythmias of the Japanese Society of Electrocardiology).
    Japanese circulation journal, 1999, Volume: 63, Issue:1

    Topics: Animals; Anti-Arrhythmia Agents; Aprindine; Humans; Imidazoles; Lidocaine; Piperidines

1999
Ventricular pacing failure after a single oral dose of pilsicainide in a patient with a permanent pacemaker and paroxysmal atrial fibrillation.
    Pacing and clinical electrophysiology : PACE, 2000, Volume: 23, Issue:9

    Topics: Administration, Oral; Aged; Anti-Arrhythmia Agents; Atrial Fibrillation; Combined Modality Therapy; Electrocardiography; Equipment Failure; Female; Humans; Lidocaine; Pacemaker, Artificial; Sick Sinus Syndrome; Time Factors

2000
New antiarrhythmic agents for atrial fibrillation.
    Current opinion in investigational drugs (London, England : 2000), 2001, Volume: 2, Issue:1

    Topics: Animals; Anti-Arrhythmia Agents; Atrial Fibrillation; Humans; Hydantoins; Imidazoles; Imidazolidines; Lidocaine; Phenethylamines; Piperazines; Sulfonamides

2001
Pilsicainide for atrial fibrillation.
    Drugs, 2006, Volume: 66, Issue:16

    Topics: Animals; Anti-Arrhythmia Agents; Atrial Fibrillation; Catheter Ablation; Combined Modality Therapy; Electrophysiologic Techniques, Cardiac; Humans; Lidocaine; Pulmonary Veins; Sodium Channel Blockers

2006
Pilsicainide.
    Drugs, 2010, Mar-05, Volume: 70, Issue:4

    Topics: Anti-Arrhythmia Agents; Humans; Lidocaine; Tachycardia

2010
Pilsicainide Poisoning: An Autopsy Case and Review of Literature.
    The American journal of forensic medicine and pathology, 2018, Volume: 39, Issue:4

    Topics: Accidents; Anti-Arrhythmia Agents; Drug Overdose; Humans; Lidocaine; Male; Middle Aged

2018
A case of acute pilsicainide intoxication mimicking viral encephalitis.
    Chudoku kenkyu : Chudoku Kenkyukai jun kikanshi = The Japanese journal of toxicology, 2017, Volume: 30, Issue:1

    Topics: Acute Disease; Anti-Arrhythmia Agents; Diagnosis, Differential; Electrocardiography; Encephalitis, Viral; Humans; Lidocaine; Male; Middle Aged; Substance-Related Disorders

2017

Trials

25 trial(s) available for pilsicainide and lidocaine

ArticleYear
Kinetics of frequency-dependent conduction delay by class I antiarrhythmic drugs in human atrium.
    Journal of cardiovascular pharmacology, 1995, Volume: 25, Issue:6

    Topics: Anti-Arrhythmia Agents; Aprindine; Cardiac Pacing, Artificial; Disopyramide; Electrophysiology; Female; Heart Atria; Heart Conduction System; Humans; Kinetics; Lidocaine; Male; Mexiletine; Middle Aged; Sodium Channels

1995
Conversion of recent-onset Atrial Fibrillation by a single oral dose of Pilsicainide (Pilsicainide Suppression Trial on atrial fibrillation). The PSTAF Investigators.
    The American journal of cardiology, 1996, Sep-15, Volume: 78, Issue:6

    Topics: Administration, Oral; Adult; Aged; Anti-Arrhythmia Agents; Atrial Fibrillation; Double-Blind Method; Female; Humans; Lidocaine; Male; Middle Aged; Time Factors; Treatment Outcome

1996
Electrophysiologic mechanisms of adverse effects of class I antiarrhythmic drugs (cibenzoline, pilsicainide, disopyramide, procainamide) in induction of atrioventricular re-entrant tachycardia.
    Cardiovascular drugs and therapy, 1996, Volume: 10, Issue:2

    Topics: Adolescent; Adult; Aged; Anti-Arrhythmia Agents; Disopyramide; Electrophysiology; Female; Heart Conduction System; Humans; Imidazoles; Lidocaine; Male; Middle Aged; Procainamide; Tachycardia, Atrioventricular Nodal Reentry; Wolff-Parkinson-White Syndrome

1996
Electrophysiologic and hemodynamic effects of a single oral dose of pilsicainide hydrochloride, a new class 1c antiarrhythmic agent.
    Journal of cardiovascular pharmacology, 1998, Volume: 31, Issue:1

    Topics: Administration, Oral; Adult; Anti-Arrhythmia Agents; Atrial Function; Electrocardiography; Electrophysiology; Female; Heart; Hemodynamics; Humans; Lidocaine; Male; Middle Aged; Tachycardia, Supraventricular

1998
Mechanism of antiarrhythmic effects of class Ic drugs in paroxysmal atrial fibrillation in man.
    Cardiology, 1998, Volume: 89, Issue:2

    Topics: Administration, Oral; Adult; Aged; Anti-Arrhythmia Agents; Atrial Fibrillation; Cardiac Pacing, Artificial; Electrocardiography; Electrophysiology; Female; Flecainide; Humans; Lidocaine; Male; Middle Aged

1998
Effect of cimetidine and probenecid on pilsicainide renal clearance in humans.
    Clinical pharmacology and therapeutics, 2000, Volume: 67, Issue:3

    Topics: Adult; Anti-Arrhythmia Agents; Chromatography, High Pressure Liquid; Cimetidine; Cross-Over Studies; Enzyme Inhibitors; Humans; Kidney; Lidocaine; Male; Probenecid; Reference Values; Uricosuric Agents

2000
Pilsicainide for conversion and maintenance of sinus rhythm in chronic atrial fibrillation: a placebo-controlled, multicenter study.
    American heart journal, 2000, Volume: 140, Issue:3

    Topics: Administration, Oral; Aged; Anti-Arrhythmia Agents; Atrial Fibrillation; Chronic Disease; Drug Administration Schedule; Electric Countershock; Female; Heart Rate; Humans; Lidocaine; Male; Middle Aged; Premedication; Prognosis; Recurrence; Treatment Outcome

2000
Single oral administration of pilsicainide versus infusion of disopyramide for termination of paroxysmal atrial fibrillation: a multicenter trial.
    Pacing and clinical electrophysiology : PACE, 2000, Volume: 23, Issue:11 Pt 2

    Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Anti-Arrhythmia Agents; Atrial Fibrillation; Circadian Rhythm; Disopyramide; Female; Heart Rate; Humans; Infusions, Intravenous; Lidocaine; Male; Middle Aged; Prospective Studies; Time Factors; Treatment Outcome

2000
Bepridil prevents paroxysmal atrial fibrillation by a class III antiarrhythmic drug effect.
    Pacing and clinical electrophysiology : PACE, 2003, Volume: 26, Issue:1P2

    Topics: Anti-Arrhythmia Agents; Atrial Fibrillation; Bepridil; Electrocardiography; Female; Flecainide; Humans; Lidocaine; Male; Middle Aged

2003
Low-dose flecainide infusion followed by oral pilsicainide is highly effective and safe for paroxysmal atrial fibrillation.
    Cardiovascular drugs and therapy, 2003, Volume: 17, Issue:1

    Topics: Anti-Arrhythmia Agents; Atrial Fibrillation; Drug Therapy, Combination; Female; Flecainide; Humans; Infusions, Intravenous; Lidocaine; Male; Middle Aged

2003
Effects of antiarrhythmic agents on left ventricular function during exercise in patients with chronic left ventricular dysfunction.
    Annals of nuclear medicine, 2004, Volume: 18, Issue:3

    Topics: Aged; Anti-Asthmatic Agents; Chronic Disease; Disopyramide; Exercise; Exercise Test; Female; Heart Ventricles; Humans; Lidocaine; Male; Mexiletine; Middle Aged; Radionuclide Imaging; Tachycardia, Ventricular; Treatment Outcome; Ventricular Dysfunction, Left

2004
Hybrid therapy with pilsicainide and pulmonary vein isolation for atrial fibrillation.
    Circulation journal : official journal of the Japanese Circulation Society, 2005, Volume: 69, Issue:12

    Topics: Anti-Arrhythmia Agents; Atrial Fibrillation; Catheter Ablation; Electrophysiology; Female; Heart Atria; Heart Block; Heart Conduction System; Humans; Lidocaine; Male; Middle Aged; Pulmonary Veins; Refractory Period, Electrophysiological; Salvage Therapy; Treatment Outcome

2005
Population pharmacokinetic and pharmacodynamic analysis of a class IC antiarrhythmic, pilsicainide, in patients with cardiac arrhythmias.
    Journal of clinical pharmacology, 2006, Volume: 46, Issue:1

    Topics: Adult; Aged; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Atrial Fibrillation; Bundle-Branch Block; Creatinine; Electrocardiography; Female; Heart Conduction System; Humans; Kidney; Lidocaine; Male; Middle Aged; Models, Biological; Sex Factors; Sodium Channel Blockers

2006
Severe arrhythmia as a result of the interaction of cetirizine and pilsicainide in a patient with renal insufficiency: first case presentation showing competition for excretion via renal multidrug resistance protein 1 and organic cation transporter 2.
    Clinical pharmacology and therapeutics, 2006, Volume: 79, Issue:4

    Topics: Administration, Oral; Adult; Aged; Animals; Anti-Arrhythmia Agents; Area Under Curve; Arrhythmias, Cardiac; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cation Transport Proteins; Cetirizine; Cross-Over Studies; Double-Blind Method; Drug Interactions; Female; Histamine H1 Antagonists, Non-Sedating; Humans; Lidocaine; Male; Oocytes; Renal Insufficiency; Xenopus

2006
Pharmacological conversion of persistent atrial fibrillation into sinus rhythm with oral pilsicainide: pilsicainide suppression trial for persistent atrial fibrillation II.
    Circulation journal : official journal of the Japanese Circulation Society, 2006, Volume: 70, Issue:6

    Topics: Administration, Oral; Adult; Aged; Anti-Arrhythmia Agents; Anticoagulants; Atrial Fibrillation; Contraindications; Double-Blind Method; Female; Humans; Lidocaine; Male; Middle Aged; Recovery of Function; Remission Induction; Thrombosis; Warfarin

2006
Randomized crossover study of the long-term effects of pilsicainide and cibenzoline in preventing recurrence of symptomatic paroxysmal atrial fibrillation: influence of the duration of arrhythmia before therapy.
    Circulation journal : official journal of the Japanese Circulation Society, 2006, Volume: 70, Issue:6

    Topics: Adult; Age Factors; Aged; Anti-Arrhythmia Agents; Atrial Fibrillation; Cross-Over Studies; Disease-Free Survival; Female; Follow-Up Studies; Humans; Imidazoles; Lidocaine; Male; Middle Aged; Recurrence; Tachycardia; Time Factors

2006
Different effect of the pure Na+ channel-blocker pilsicainide on the ST-segment response in the right precordial leads in patients with normal left ventricular function.
    Circulation journal : official journal of the Japanese Circulation Society, 2007, Volume: 71, Issue:1

    Topics: Adult; Aged; Algorithms; Brugada Syndrome; Electrocardiography; Female; Heart Diseases; Humans; Lidocaine; Male; Middle Aged; Prospective Studies; Sodium Channel Blockers; Ventricular Function, Left

2007
Discrimination of Brugada syndrome patients from individuals with the saddle-back type ST-segment elevation using a marker of the standard 12-lead electrocardiography.
    Circulation journal : official journal of the Japanese Circulation Society, 2007, Volume: 71, Issue:4

    Topics: Adult; Aged; Arrhythmias, Cardiac; Biomarkers; Brugada Syndrome; Diagnosis, Differential; Electrocardiography; Female; Humans; Lidocaine; Male; Middle Aged; Sodium Channel Blockers

2007
Clinical significance of macroscopic T-wave alternans after sodium channel blocker administration in patients with Brugada syndrome.
    Journal of cardiovascular electrophysiology, 2008, Volume: 19, Issue:1

    Topics: Brugada Syndrome; Electrocardiography; Female; Humans; Lidocaine; Male; Middle Aged; Sodium Channel Blockers; Ventricular Fibrillation

2008
Sodium channel blockers enhance the temporal QT interval variability in the right precordial leads in Brugada syndrome.
    Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc, 2008, Volume: 13, Issue:1

    Topics: Brugada Syndrome; Electrocardiography; Electrophysiologic Techniques, Cardiac; Female; Heart Rate; Humans; Lidocaine; Male; Middle Aged; Sodium Channel Blockers; Time Factors

2008
Use of bepridil in combination with Ic antiarrhythmic agent in converting persistent atrial fibrillation to sinus rhythm.
    Circulation journal : official journal of the Japanese Circulation Society, 2008, Volume: 72, Issue:5

    Topics: Adult; Aged; Anti-Arrhythmia Agents; Atrial Fibrillation; Atrial Natriuretic Factor; Bepridil; Drug Therapy, Combination; Electrocardiography; Female; Flecainide; Follow-Up Studies; Humans; Imidazoles; Lidocaine; Male; Middle Aged; Natriuretic Peptide, Brain; Sinoatrial Node; Treatment Outcome

2008
A randomized study on the efficacy of intravenous cibenzoline and pilsicainide administered prior to electrical cardioversion in patients with lone paroxysmal and persistent atrial fibrillation.
    Journal of cardiology, 2009, Volume: 53, Issue:1

    Topics: Aged; Anti-Arrhythmia Agents; Atrial Fibrillation; Atrial Natriuretic Factor; Electric Countershock; Female; Humans; Imidazoles; Injections, Intravenous; Lidocaine; Male

2009
An open-label, single-dose, parallel-group, dose-increasing study comparing the pharmacokinetics and tolerability of pilsicainide hydrochloride in healthy Korean and Japanese male subjects.
    Clinical therapeutics, 2009, Volume: 31, Issue:3

    Topics: Adult; Anti-Arrhythmia Agents; Area Under Curve; Asian People; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Electrocardiography; Humans; Japan; Korea; Lidocaine; Male; Reference Values; Young Adult

2009
Predicting the efficacy of antiarrhythmic agents for interrupting persistent atrial fibrillation according to spectral analysis of the fibrillation waves on the surface ECG.
    Circulation journal : official journal of the Japanese Circulation Society, 2009, Volume: 73, Issue:7

    Topics: Aged; Anti-Arrhythmia Agents; Atrial Fibrillation; Bepridil; Cross-Over Studies; Electrocardiography; Electrophysiologic Techniques, Cardiac; Female; Humans; Lidocaine; Male; Middle Aged; Sensitivity and Specificity; Spectrum Analysis; Treatment Outcome

2009
Pharmacokinetics of pilsicainide hydrochloride for injection in healthy Chinese volunteers: a randomized, parallel-group, open-label, single-dose study.
    Clinical therapeutics, 2014, Feb-01, Volume: 36, Issue:2

    Topics: Administration, Intravenous; Adult; Anti-Arrhythmia Agents; Chemistry, Pharmaceutical; China; Dose-Response Relationship, Drug; Drugs, Generic; Female; Humans; Lidocaine; Male

2014

Other Studies

168 other study(ies) available for pilsicainide and lidocaine

ArticleYear
New antiarrhythmic agents. N-aryl-8-pyrrolizidinealkanamides.
    Journal of medicinal chemistry, 1985, Volume: 28, Issue:6

    Topics: Animals; Anti-Arrhythmia Agents; Lidocaine; Male; Mice; Mice, Inbred Strains; Structure-Activity Relationship

1985
Identification of "toxicophoric" features for predicting drug-induced QT interval prolongation.
    European journal of medicinal chemistry, 2008, Volume: 43, Issue:11

    Topics: Amino Acid Sequence; Heart; Humans; Models, Molecular; Molecular Sequence Data; Molecular Structure; Protein Subunits; Sequence Alignment; Structure-Activity Relationship; Trans-Activators; Transcriptional Regulator ERG

2008
Predicting hERG activities of compounds from their 3D structures: development and evaluation of a global descriptors based QSAR model.
    European journal of medicinal chemistry, 2011, Volume: 46, Issue:2

    Topics: Computer Simulation; Ether-A-Go-Go Potassium Channels; Humans; Molecular Structure; Organic Chemicals; Quantitative Structure-Activity Relationship

2011
Blockade of 2,4-dinitrophenol induced ATP sensitive potassium current in guinea pig ventricular myocytes by class I antiarrhythmic drugs.
    Cardiovascular research, 1992, Volume: 26, Issue:11

    Topics: 2,4-Dinitrophenol; Action Potentials; Adenosine Triphosphate; Animals; Anti-Arrhythmia Agents; Dinitrophenols; Disopyramide; Flecainide; Glyburide; Guinea Pigs; Heart Ventricles; Imidazoles; Lidocaine; Mexiletine; Myocardium; Piperidines; Potassium; Procainamide; Pyridines

1992
[Pharmacokinetics and pharmacodynamics of class I antiarrhythmic agents after a single oral administration].
    Japanese circulation journal, 1992, Volume: 56 Suppl 5

    Topics: Administration, Oral; Anti-Arrhythmia Agents; Aprindine; Flecainide; Humans; Imidazoles; Lidocaine; Mexiletine; Piperidines; Propafenone

1992
Modes of the Na channel blocking action of pilsicainide, a new antiarrhythmic agent, in cardiac cells.
    Japanese journal of pharmacology, 1992, Volume: 58, Issue:4

    Topics: Animals; Anti-Arrhythmia Agents; Guinea Pigs; Heart; In Vitro Techniques; Lidocaine; Myocardium; Sodium Channels

1992
[Clinical significance of the use-dependent sodium channel block and reverse use-dependent potassium channel block of class I and class III antiarrhythmic agents and their values to predict drug efficacy].
    Japanese circulation journal, 1992, Volume: 56 Suppl 5

    Topics: Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Disopyramide; Drug Evaluation; Electrocardiography, Ambulatory; Electrophysiology; Exercise Test; Humans; Lidocaine; Mexiletine; Middle Aged; Potassium Channels; Sodium Channels

1992
[Estimation of depressant effects of class I antiarrhythmic drugs on intraventricular conduction--rate-dependent effects on QRS duration].
    Japanese circulation journal, 1992, Volume: 56 Suppl 5

    Topics: Anti-Arrhythmia Agents; Aprindine; Depression, Chemical; Disopyramide; Electrocardiography; Flecainide; Heart Conduction System; Heart Rate; Humans; Lidocaine; Mexiletine; Sodium Channels; Ventricular Function

1992
Effects of SUN-1165, N-(2,6-dimethylphenyl)-8-pyrrolizidine acetamide hydrochloride hemihydrate, a new class I antiarrhythmic drug, on ventricular arrhythmias, intraventricular conduction, and the refractory period in canine myocardial infarction.
    Journal of cardiovascular pharmacology, 1992, Volume: 19, Issue:3

    Topics: Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Disease Models, Animal; Dogs; Electric Stimulation; Electrocardiography; Heart Conduction System; Lidocaine; Myocardial Infarction; Refractory Period, Electrophysiological; Ventricular Function

1992
Mechanisms of the anticholinergic effect of SUN 1165 in comparison with flecainide, disopyramide and quinidine in single atrial myocytes isolated from guinea-pig.
    British journal of pharmacology, 1991, Volume: 104, Issue:4

    Topics: Acetylcholine; Animals; Anti-Arrhythmia Agents; Disopyramide; Flecainide; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; Guinea Pigs; Heart; In Vitro Techniques; Lidocaine; Male; Myocardium; Parasympatholytics; Potassium Channels; Quinidine; Receptors, Cholinergic

1991
Suppressive effect of SUN1165 on supraventricular tachycardia.
    American heart journal, 1991, Volume: 121, Issue:5

    Topics: Administration, Oral; Adult; Anti-Arrhythmia Agents; Cardiac Pacing, Artificial; Electrocardiography; Female; Heart Conduction System; Humans; Lidocaine; Male; Middle Aged; Tachycardia, Atrioventricular Nodal Reentry; Tachycardia, Supraventricular; Wolff-Parkinson-White Syndrome

1991
Pharmacokinetics of SUN 1165, a new antiarrhythmic agent, in renal dysfunction.
    European journal of clinical pharmacology, 1991, Volume: 40, Issue:4

    Topics: Acute Kidney Injury; Administration, Oral; Adult; Aged; Aged, 80 and over; Anti-Arrhythmia Agents; Chromatography, High Pressure Liquid; Creatinine; Female; Half-Life; Humans; Lidocaine; Male; Middle Aged

1991
Canine digitalis arrhythmia as a model for detecting Na-channel blocking antiarrhythmic drugs: a comparative study using other canine arrhythmia models and the new antiarrhythmic drugs, propafenone, tocainide, and SUN 1165.
    Heart and vessels, 1985, Volume: 1, Issue:1

    Topics: Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Coronary Vessels; Dogs; Epinephrine; Female; Ion Channels; Lidocaine; Ligation; Male; Ouabain; Propafenone; Propiophenones; Sodium; Tocainide

1985
SUN 1165: a new antiarrhythmic Na current blocker in ventricular myocytes of guinea-pig.
    Comparative biochemistry and physiology. C, Comparative pharmacology and toxicology, 1987, Volume: 87, Issue:2

    Topics: Action Potentials; Animals; Dose-Response Relationship, Drug; Guinea Pigs; Heart; Ion Channels; Kinetics; Lidocaine; Male; Myocardial Contraction; Myocardium; Sodium

1987
Mechanism of inhibition by SUN 1165, a new Na channel blocking antiarrhythmic agent, of cardiac glycoside-induced triggered activity.
    European journal of pharmacology, 1988, Jan-19, Volume: 145, Issue:3

    Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Caffeine; Dogs; Egtazic Acid; Electric Stimulation; Female; Heart Conduction System; In Vitro Techniques; Ion Channels; Lidocaine; Male; Perfusion; Purkinje Fibers; Strophanthidin

1988
Effect of SUN 1165, a new potent antiarrhythmic agent, on the kinetics of rate-dependent block of Na channels and ventricular conduction of extrasystoles.
    Journal of cardiovascular pharmacology, 1988, Volume: 11, Issue:4

    Topics: Animals; Anti-Arrhythmia Agents; Benzeneacetamides; Cardiac Complexes, Premature; Disopyramide; Guinea Pigs; Heart Conduction System; Heart Ventricles; In Vitro Techniques; Ion Channels; Lidocaine; Male; Mexiletine; Papillary Muscles; Piperidines; Sodium

1988
Different time courses of the blockade of sodium current by lignocaine and SUN 1165 in single myocytes isolated from guinea-pig atrium.
    British journal of pharmacology, 1989, Volume: 98, Issue:1

    Topics: Animals; Anti-Arrhythmia Agents; Guinea Pigs; Heart; Humans; In Vitro Techniques; Lidocaine; Male; Myocardium; Sodium Channels; Time Factors

1989
Effects of N-(2,6-dimethylphenyl)-8-pyrrolizidineacetamide hydrochloride hemihydrate on the ventriculo-atrial conductivity of accessory pathways.
    Arzneimittel-Forschung, 1989, Volume: 39, Issue:8

    Topics: Administration, Oral; Adolescent; Adult; Aged; Anti-Arrhythmia Agents; Atrioventricular Node; Electrophysiology; Female; Heart Conduction System; Humans; Lidocaine; Male; Middle Aged; Neural Conduction; Neural Pathways; Tachycardia, Atrioventricular Nodal Reentry

1989
The effects of SUN 1165, a novel sodium channel blocker, on ischemia-induced mitochondrial dysfunction and leakage of lysosomal enzymes in canine hearts.
    Biochemical and biophysical research communications, 1988, Dec-15, Volume: 157, Issue:2

    Topics: Animals; Blood Pressure; Cattle; Coronary Disease; Female; Heart; Lidocaine; Lysosomes; Male; Mitochondria; Oxygen Consumption; Sodium Channels

1988
Use-dependent blocking action of newly developed lidocaine-analogs on maximum rate of rise of action potentials in guinea pig papillary muscle.
    Japanese heart journal, 1987, Volume: 28, Issue:2

    Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Depression, Chemical; Guinea Pigs; Kinetics; Lidocaine; Mexiletine; Papillary Muscles; Structure-Activity Relationship; Tocainide

1987
General pharmacological studies on N-(2,6-dimethylphenyl)-8-pyrrolizidineacetamide hydrochloride hemihydrate. 1st communication: effect on the central nervous system.
    Arzneimittel-Forschung, 1988, Volume: 38, Issue:10

    Topics: Administration, Oral; Animals; Anti-Arrhythmia Agents; Body Temperature; Catalepsy; Cats; Central Nervous System; Chemical Phenomena; Chemistry; Disopyramide; Dogs; Electroencephalography; Female; Hypothermia; Lidocaine; Male; Mexiletine; Mice; Motor Activity; Muscle Relaxation; Pain; Rabbits; Rats; Rats, Inbred Strains; Seizures; Tremor; Vomiting

1988
General pharmacological studies on N-(2,6-dimethylphenyl)-8-pyrrolizidineacetamide hydrochloride hemihydrate. 2nd communication: effect on the peripheral nervous system and peripheral organs.
    Arzneimittel-Forschung, 1988, Volume: 38, Issue:10

    Topics: Animals; Anti-Arrhythmia Agents; Autonomic Nervous System; Capillary Permeability; Chemical Phenomena; Chemistry; Digestive System; Disopyramide; Endocrine Glands; Female; Gastric Mucosa; Gastrointestinal Motility; Guinea Pigs; Ileum; Lidocaine; Male; Mexiletine; Mice; Peripheral Nerves; Pregnancy; Pupil; Rabbits; Rats; Rats, Inbred Strains; Trachea; Urinary Bladder; Urogenital System; Uterus; Vas Deferens

1988
General pharmacological studies on N-(2,6-dimethylphenyl)-8-pyrrolizidineacetamide hydrochloride hemihydrate. 3rd communication: effect on cardiovascular system.
    Arzneimittel-Forschung, 1988, Volume: 38, Issue:10

    Topics: Animals; Anti-Arrhythmia Agents; Blood Flow Velocity; Blood Pressure; Cardiac Output; Chemical Phenomena; Chemistry; Dogs; Energy Metabolism; Female; Heart; Heart Rate; Hemodynamics; Kidney; Lidocaine; Male; Myocardial Contraction; Rats; Rats, Inbred SHR; Rats, Inbred Strains; Respiration

1988
N-(2,6-Dimethylphenyl)-8-pyrrolizidineacetamide hydrochloride hemihydrate (SUN 1165): a new potent and long-acting antiarrhythmic agent.
    Arzneimittel-Forschung, 1985, Volume: 35, Issue:8

    Topics: Anesthetics, Local; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Cell Membrane; Coronary Circulation; Coronary Vessels; Disopyramide; Dogs; Epinephrine; Female; Guinea Pigs; Halothane; In Vitro Techniques; Lidocaine; Male; Myocardial Contraction; Ouabain; Papillary Muscles

1985
N-(2,6-dimethylphenyl)-8-pyrrolizidineacetamide hydrochloride hemihydrate (SUN 1165), a new antiarrhythmic agent: effects on cardiac conduction.
    Arzneimittel-Forschung, 1985, Volume: 35, Issue:9

    Topics: Animals; Anti-Arrhythmia Agents; Dogs; Duodenum; Electrocardiography; Female; Heart Conduction System; In Vitro Techniques; Infusions, Parenteral; Injections; Injections, Intra-Arterial; Injections, Intravenous; Lidocaine; Male; Rabbits; Refractory Period, Electrophysiological

1985
Effects of a new antiarrhythmic compound SUN 1165 [N-(2,6-dimethylphenyl)-8-pyrrolizidineacetamide hydrochloride] on the sodium currents in isolated single rat ventricular cells.
    Naunyn-Schmiedeberg's archives of pharmacology, 1984, Volume: 326, Issue:2

    Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Electrophysiology; Heart; In Vitro Techniques; Ion Channels; Lidocaine; Microelectrodes; Myocardium; Rats; Sodium

1984
Ischemia enhances use-dependent sodium channel blockade by pilsicainide, a class IC antiarrhythmic agent.
    Journal of the American College of Cardiology, 1994, Volume: 23, Issue:6

    Topics: Acute Disease; Aged; Analysis of Variance; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Chi-Square Distribution; Drug Evaluation; Electrocardiography; Exercise Test; Female; Humans; Lidocaine; Male; Middle Aged; Myocardial Ischemia; Risk Factors; Sodium Channels

1994
Slow abnormal conduction in the low right atrium: its anatomic basis and relevance to atrial reentry.
    American heart journal, 1994, Volume: 127, Issue:2

    Topics: Animals; Anti-Arrhythmia Agents; Atrial Flutter; Atrial Function, Right; Dogs; Electric Stimulation; Electrocardiography; Female; Heart Atria; Heart Block; Heart Conduction System; Lidocaine; Male; Piperidines; Pyridines; Refractory Period, Electrophysiological; Time Factors

1994
Effects of pilsicainide on systemic hemodynamics and cardiac function of anesthetized dogs.
    Cardioscience, 1993, Volume: 4, Issue:4

    Topics: Anesthesia, Intravenous; Animals; Anti-Arrhythmia Agents; Depression, Chemical; Dogs; Female; Flecainide; Heart; Hemodynamics; Lidocaine; Male; Myocardial Contraction; Propafenone

1993
[Effect of pilsicainide hydrochloride on atrial fibrillation threshold].
    Kokyu to junkan. Respiration & circulation, 1993, Volume: 41, Issue:8

    Topics: Adult; Aged; Anti-Arrhythmia Agents; Atrial Fibrillation; Electrocardiography; Female; Humans; Lidocaine; Male; Middle Aged

1993
Improvement of ischemia/reperfusion-induced contractile dysfunction of perfused hearts by class Ic antiarrhythmic agents.
    The Journal of pharmacology and experimental therapeutics, 1993, Volume: 266, Issue:3

    Topics: Adenosine Triphosphate; Animals; Anti-Arrhythmia Agents; Creatine Kinase; Flecainide; Heart; Lidocaine; Male; Metals; Myocardial Contraction; Myocardial Ischemia; Myocardial Reperfusion Injury; Myocardium; Perfusion; Rats; Rats, Wistar; Ventricular Function, Left

1993
Clinical evaluation of the use-dependent QRS prolongation and the reverse use-dependent QT prolongation of class I and class III antiarrhythmic agents and their value in predicting efficacy.
    American heart journal, 1993, Volume: 126, Issue:1

    Topics: Adult; Aged; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Disopyramide; Drug Evaluation; Electrocardiography, Ambulatory; Exercise Test; Female; Heart Rate; Humans; Lidocaine; Male; Mexiletine; Middle Aged; Piperidines; Potassium Channels; Pyridines; Sodium Channels

1993
Effects of pilsicainide on the atrial fibrillation threshold in guinea pig atria. A comparative study with disopyramide, lidocaine and flecainide.
    Japanese heart journal, 1993, Volume: 34, Issue:3

    Topics: Animals; Anti-Arrhythmia Agents; Atrial Fibrillation; Disopyramide; Electrophysiology; Female; Flecainide; Guinea Pigs; Heart; Heart Atria; In Vitro Techniques; Lidocaine; Male

1993
Antiarrhythmic agents act differently on the activation phase of the ACh-response in guinea-pig atrial myocytes.
    British journal of pharmacology, 1993, Volume: 108, Issue:1

    Topics: Acetylcholine; Animals; Anti-Arrhythmia Agents; Disopyramide; Electric Conductivity; Flecainide; Guinea Pigs; Lidocaine; Male; Myocardium; Potassium; Potassium Channels; Propafenone

1993
Mechanisms of negative inotropic effects of class Ic antiarrhythmic agents: comparative study of the effects of flecainide and pilsicainide on intracellular calcium handling in dog ventricular myocardium.
    Journal of cardiovascular pharmacology, 1996, Volume: 27, Issue:1

    Topics: Animals; Anti-Arrhythmia Agents; Calcium; Calcium Channels; Depression, Chemical; Dogs; Dose-Response Relationship, Drug; Flecainide; Heart Ventricles; Lidocaine; Myocardial Contraction; Myocardium; Sarcolemma

1996
Idiopathic ventricular fibrillation initiated by a short-coupled ventricular premature beat.
    Japanese heart journal, 1996, Volume: 37, Issue:2

    Topics: Adult; Anti-Arrhythmia Agents; Cardiac Complexes, Premature; Drug Therapy, Combination; Electrocardiography; Humans; Lidocaine; Male; Propranolol; Ventricular Fibrillation; Verapamil

1996
The rise time of the monophasic action potential--a new index of local use-dependent conductivity by sodium channel blockers in human myocardium.
    Japanese circulation journal, 1997, Volume: 61, Issue:12

    Topics: Action Potentials; Adult; Aged; Aged, 80 and over; Anti-Arrhythmia Agents; Disopyramide; Female; Heart; Heart Conduction System; Humans; Injections, Intravenous; Lidocaine; Male; Middle Aged; Sodium Channel Blockers; Sodium Channels

1997
Different effects of class Ic and III antiarrhythmic drugs on vagotonic atrial fibrillation in the canine heart.
    Journal of cardiovascular pharmacology, 1998, Volume: 31, Issue:1

    Topics: Animals; Anti-Arrhythmia Agents; Atrial Fibrillation; Atrial Function; Dogs; Electric Stimulation; Female; Lidocaine; Male; Pyrimidinones; Vagus Nerve

1998
Class I antiarrhythmic drugs alter the severity of myocardial stunning by modulating ATP-sensitive K+ channels in guinea pig ventricular muscles.
    Naunyn-Schmiedeberg's archives of pharmacology, 1998, Volume: 357, Issue:3

    Topics: Animals; Anti-Arrhythmia Agents; Glyburide; Guinea Pigs; Heart; Heart Ventricles; Imidazoles; Lidocaine; Male; Mexiletine; Myocardial Stunning; Potassium Channels

1998
[Efficacy and safety of a single oral dose of pilsicainide in supraventricular arrhythmia after coronary artery bypass grafting].
    The Japanese journal of thoracic and cardiovascular surgery : official publication of the Japanese Association for Thoracic Surgery = Nihon Kyobu Geka Gakkai zasshi, 1998, Volume: 46, Issue:4

    Topics: Aged; Aged, 80 and over; Anti-Arrhythmia Agents; Coronary Artery Bypass; Female; Humans; Lidocaine; Male; Middle Aged; Postoperative Complications; Tachycardia, Supraventricular

1998
Uniqueness of pilsicainide in class Ic antiarrhythmics.
    Japanese heart journal, 1998, Volume: 39, Issue:3

    Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Atrial Function; Calcium Channels; Dose-Response Relationship, Drug; Heart Atria; Lidocaine; Membrane Potentials; Patch-Clamp Techniques; Potassium Channels; Rabbits

1998
Class IC antiarrhythmic drugs, flecainide and pilsicainide, produce ST segment elevation simulating inferior myocardial ischemia.
    Journal of cardiovascular electrophysiology, 1998, Volume: 9, Issue:8

    Topics: Anti-Arrhythmia Agents; Diagnosis, Differential; Drug Therapy, Combination; Electrocardiography; Flecainide; Heart; Humans; Lidocaine; Male; Middle Aged; Myocardial Ischemia; Tachycardia, Ventricular

1998
Effects of pilsicainide and propafenone on vagally induced atrial fibrillation: role of suppressant effect in conductivity.
    European journal of pharmacology, 1998, Aug-28, Volume: 356, Issue:1

    Topics: Animals; Anti-Arrhythmia Agents; Atrial Fibrillation; Cardiac Output; Dogs; Electric Conductivity; Electric Stimulation; Electrophysiology; Female; Heart Atria; Heart Rate; Humans; Lidocaine; Male; Propafenone; Vagus Nerve

1998
Postrepolarization refractoriness as a potential anti-atrial fibrillation mechanism of pilsicainide, a pure sodium channel blocker with slow recovery kinetics.
    Cardiovascular drugs and therapy, 1998, Volume: 12, Issue:5

    Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Atrial Fibrillation; Dogs; Drug Evaluation, Preclinical; Female; Kinetics; Lidocaine; Male; Sodium Channel Blockers

1998
Dispersion of signal-averaged P wave duration on precordial body surface in patients with paroxysmal atrial fibrillation.
    European heart journal, 1999, Volume: 20, Issue:3

    Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Anti-Arrhythmia Agents; Atrial Fibrillation; Body Surface Potential Mapping; Female; Follow-Up Studies; Heart Rate; Humans; Lidocaine; Male; Middle Aged; Prognosis; Prospective Studies; Recurrence; ROC Curve; Tachycardia, Paroxysmal

1999
ST segment elevation in the right precordial leads induced with class IC antiarrhythmic drugs: insight into the mechanism of Brugada syndrome.
    Journal of cardiovascular electrophysiology, 1999, Volume: 10, Issue:2

    Topics: Anti-Arrhythmia Agents; Atrial Fibrillation; Electrocardiography; Flecainide; Follow-Up Studies; Heart Rate; Humans; Lidocaine; Male; Middle Aged; Procainamide; Recurrence; Tachycardia, Paroxysmal; Tachycardia, Ventricular; Wolff-Parkinson-White Syndrome

1999
Pilsicainide intoxication in a patient with dehydration.
    Japanese circulation journal, 1999, Volume: 63, Issue:3

    Topics: Aged; Aged, 80 and over; Anti-Arrhythmia Agents; Atrial Fibrillation; Dehydration; Electrocardiography; Female; Humans; Lidocaine; Poisoning

1999
Effect of pilsicainide, a pure sodium channel blocker, on spiral waves during atrial fibrillation: theoretical analysis by numerical simulation.
    Journal of electrocardiology, 1999, Volume: 32, Issue:4

    Topics: Anti-Arrhythmia Agents; Atrial Fibrillation; Computer Simulation; Culture Techniques; Electrocardiography; Heart Atria; Humans; Lidocaine; Signal Processing, Computer-Assisted; Sodium Channel Blockers; Sodium Channels

1999
Determination of refractory periods and conduction velocity during atrial fibrillation using atrial capture in dogs: direct assessment of the wavelength and its modulation by a sodium channel blocker, pilsicainide.
    Journal of the American College of Cardiology, 2000, Volume: 35, Issue:1

    Topics: Animals; Anti-Arrhythmia Agents; Atrial Fibrillation; Cardiac Pacing, Artificial; Dogs; Electrocardiography; Female; Lidocaine; Male; Signal Processing, Computer-Assisted; Sodium Channels

2000
Selective block of late currents in the DeltaKPQ Na(+) channel mutant by pilsicainide and lidocaine with distinct mechanisms.
    Molecular pharmacology, 2000, Volume: 57, Issue:2

    Topics: Animals; Anti-Arrhythmia Agents; Cells, Cultured; Cricetinae; Electrophysiology; Humans; Lidocaine; Long QT Syndrome; Myocardium; Sodium Channel Blockers; Sodium Channels; Transfection

2000
Effect of Valsalva maneuver on surface electrocardiographic P-wave dispersion in paroxysmal atrial fibrillation.
    The American journal of cardiology, 2000, Apr-01, Volume: 85, Issue:7

    Topics: Anti-Arrhythmia Agents; Atrial Fibrillation; Electrocardiography; Female; Heart Rate; Humans; Lidocaine; Male; Middle Aged; Prognosis; Sympathetic Nervous System; Tachycardia, Paroxysmal; Valsalva Maneuver

2000
Transient appearance of antegrade conduction via an AV accessory pathway caused by atrial fibrillation in a patient with intermittent Wolff-Parkinson-White syndrome.
    Heart (British Cardiac Society), 2000, Volume: 83, Issue:5

    Topics: Administration, Oral; Anti-Arrhythmia Agents; Atrial Fibrillation; Disopyramide; Electrocardiography; Heart Conduction System; Humans; Injections, Intravenous; Lidocaine; Male; Middle Aged; Procainamide; Wolff-Parkinson-White Syndrome

2000
[Antiarrhythmic effects of pilsicainide hydrochloride and effects on cardiac function and ECG in dogs: comparison with disopyramide].
    Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 2000, Volume: 115, Issue:5

    Topics: Anesthesia; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Coronary Vessels; Disease Models, Animal; Disopyramide; Dogs; Dose-Response Relationship, Drug; Electrocardiography; Female; Hemodynamics; Infusions, Intravenous; Lidocaine; Ligation

2000
A case of sinus pause due to the proarrhythmia of pilsicainide.
    Japanese heart journal, 2000, Volume: 41, Issue:3

    Topics: Administration, Oral; Aged; Anti-Arrhythmia Agents; Atrial Fibrillation; Consciousness Disorders; Electrocardiography; Humans; Lidocaine; Male; Sodium Channel Blockers

2000
QT-prolonging class I drug, disopyramide, does not aggravate but suppresses adrenaline-induced arrhythmias. Comparison with cibenzoline and pilsicainide.
    European journal of pharmacology, 2000, Jul-21, Volume: 400, Issue:2-3

    Topics: Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Blood Pressure; Disopyramide; Dogs; Drug Interactions; Electrocardiography; Epinephrine; Female; Heart Rate; Imidazoles; Lidocaine; Male

2000
Effect of a single oral dose of pilsicainide on pacing thresholds in pacemaker patients with and without paroxysmal atrial fibrillation.
    Japanese circulation journal, 2000, Volume: 64, Issue:10

    Topics: Administration, Oral; Aged; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Atrial Fibrillation; Cardiac Pacing, Artificial; Drug Evaluation; Female; Humans; Lidocaine; Male; Pacemaker, Artificial

2000
ST segment elevation in the right precordial leads following administration of class Ic antiarrhythmic drugs.
    Heart (British Cardiac Society), 2001, Volume: 85, Issue:1

    Topics: Aged; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Atrial Fibrillation; Electrocardiography; Female; Flecainide; Humans; Lidocaine; Male; Middle Aged; Retrospective Studies

2001
Relatively benign clinical course in asymptomatic patients with brugada-type electrocardiogram without family history of sudden death.
    Journal of cardiovascular electrophysiology, 2001, Volume: 12, Issue:1

    Topics: Adult; Anti-Arrhythmia Agents; Bundle-Branch Block; Death, Sudden, Cardiac; Electrocardiography; Electrophysiology; Follow-Up Studies; Humans; Lidocaine; Male; Medical Records; Middle Aged; Neural Conduction; Prognosis; Reaction Time; Syndrome; Ventricular Fibrillation

2001
Syncope in patients with atrial flutter during treatment with class Ic antiarrhythmic drugs.
    Journal of electrocardiology, 2001, Volume: 34, Issue:1

    Topics: Adult; Anti-Arrhythmia Agents; Atrial Flutter; Catheter Ablation; Electrocardiography; Electrophysiologic Techniques, Cardiac; Exercise; Flecainide; Humans; Lidocaine; Male; Middle Aged; Syncope; Tachycardia

2001
Appropriate dosing of pilsicainide hydrochloride in patients on hemodialysis.
    Nephron, 2001, Volume: 88, Issue:2

    Topics: Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Atrial Premature Complexes; Echocardiography; Electrocardiography, Ambulatory; Female; Humans; Kidney Failure, Chronic; Lidocaine; Male; Middle Aged; Renal Dialysis

2001
ELISA for the quantification of pilsicainide.
    Biological & pharmaceutical bulletin, 2001, Volume: 24, Issue:10

    Topics: Animals; Anti-Arrhythmia Agents; beta-Galactosidase; Chromatography, High Pressure Liquid; Enzyme-Linked Immunosorbent Assay; Female; Immunoglobulin G; Indicators and Reagents; Lidocaine; Rabbits; Spectrophotometry, Infrared

2001
[Efficacy of pilsicainide for the long-term prevention of paroxysmal atrial fibrillation: analysis based on the time of onset].
    Journal of cardiology, 2001, Volume: 38, Issue:4

    Topics: Aged; Anti-Arrhythmia Agents; Atrial Fibrillation; Electric Countershock; Female; Humans; Hypertension; Lidocaine; Male; Time

2001
Effects of ionic remodeling on cardiac antiarrhythmic drug actions.
    Journal of cardiovascular pharmacology, 2001, Volume: 38, Issue:6

    Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Atrial Fibrillation; Down-Regulation; Electric Conductivity; Heart Failure; Humans; Ion Channels; Ion Transport; Lidocaine; Potassium Channel Blockers; Refractory Period, Electrophysiological; Tachycardia, Ectopic Atrial; Torsades de Pointes

2001
Electropharmacologic effects of pilsicainide, a pure sodium channel blocker, on the remodeled atrium subjected to chronic rapid pacing.
    Journal of cardiovascular pharmacology, 2001, Volume: 38, Issue:6

    Topics: Animals; Anti-Arrhythmia Agents; Atrial Fibrillation; Atrial Function; Cardiac Pacing, Artificial; Chronic Disease; Dogs; Electrodes, Implanted; Female; Lidocaine; Male; Neural Conduction; Refractory Period, Electrophysiological; Sodium Channel Blockers; Time Factors

2001
Images in cardiology: Successful treatment of atrial tachycardia-induced cardiomyopathy with pilsicainide.
    Heart (British Cardiac Society), 2001, Volume: 86, Issue:6

    Topics: Adolescent; Anti-Arrhythmia Agents; Cardiomegaly; Female; Humans; Lidocaine; Radiography; Stroke Volume; Tachycardia

2001
Paradoxic abbreviation of repolarization in epicardium of the right ventricular outflow tract during augmentation of Brugada-type ST segment elevation.
    Journal of cardiovascular electrophysiology, 2001, Volume: 12, Issue:12

    Topics: Anti-Arrhythmia Agents; Bundle-Branch Block; Cardiotonic Agents; Electrocardiography; Heart Ventricles; Humans; Isoproterenol; Lidocaine; Male; Middle Aged; Syndrome; Ventricular Fibrillation; Ventricular Function, Right

2001
Class I antiarrhythmic drug and coronary vasospasm-induced T wave alternans and ventricular tachyarrhythmia in a patient with Brugada syndrome and vasospastic angina.
    Journal of cardiovascular electrophysiology, 2002, Volume: 13, Issue:2

    Topics: Acetylcholine; Angina Pectoris, Variant; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Atrial Fibrillation; Bundle-Branch Block; Humans; Lidocaine; Male; Middle Aged; Tachycardia, Ventricular; Vasodilator Agents; Ventricular Premature Complexes

2002
J wave and ST segment elevation in the inferior leads: a latent type of variant Brugada syndrome?
    Japanese heart journal, 2002, Volume: 43, Issue:1

    Topics: Adult; Bundle-Branch Block; Diagnosis, Differential; Electrocardiography; Humans; Lidocaine; Male; Sodium Channel Blockers; Syndrome; Tachycardia, Ventricular; Ventricular Fibrillation

2002
Quantification of pilsicainide in serum by capillary electrophoresis.
    Journal of pharmaceutical and biomedical analysis, 2002, Jul-20, Volume: 29, Issue:4

    Topics: Anti-Arrhythmia Agents; Electrophoresis, Capillary; Humans; Lidocaine; Reproducibility of Results; Sensitivity and Specificity

2002
Pilsicanide-induced marked T wave alternans and ventricular fibrillation in a patient with Brugada syndrome.
    Journal of cardiovascular electrophysiology, 2002, Volume: 13, Issue:8

    Topics: Adult; Anti-Arrhythmia Agents; Bundle-Branch Block; Electrocardiography; Humans; Lidocaine; Long QT Syndrome; Male; Syndrome; Ventricular Fibrillation

2002
[Brugada syndrome occurring in an identical twin: a case report].
    Journal of cardiology, 2002, Volume: 40, Issue:3

    Topics: Anti-Arrhythmia Agents; Bundle-Branch Block; Diseases in Twins; Electrocardiography; Humans; Lidocaine; Male; Middle Aged; NAV1.5 Voltage-Gated Sodium Channel; Sodium Channels; Syndrome; Twins, Monozygotic; Ventricular Fibrillation

2002
Atrial fibrillation threshold predicted long-term efficacy of pharmacological treatment of patients without structural heart disease.
    Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology, 2002, Volume: 4, Issue:4

    Topics: Aged; Anti-Arrhythmia Agents; Aprindine; Atrial Fibrillation; Disopyramide; Electrophysiologic Techniques, Cardiac; Female; Flecainide; Humans; Imidazoles; Lidocaine; Male; Middle Aged; Treatment Outcome

2002
Evaluation of the effect of bepridil on paroxysmal atrial fibrillation: relationship between efficacy and the f-f interval in surface ECG recordings.
    Circulation journal : official journal of the Japanese Circulation Society, 2003, Volume: 67, Issue:1

    Topics: Aged; Anti-Arrhythmia Agents; Atrial Fibrillation; Bepridil; Calcium Channel Blockers; Electrocardiography; Female; Flecainide; Humans; Lidocaine; Male; Middle Aged; Sodium Channel Blockers; Treatment Outcome

2003
Widening of the excitable gap and enlargement of the core of reentry during atrial fibrillation with a pure sodium channel blocker in canine atria.
    Circulation, 2003, Feb-18, Volume: 107, Issue:6

    Topics: Acetylcholine; Animals; Atrial Fibrillation; Body Surface Potential Mapping; Dogs; Dose-Response Relationship, Drug; Electrocardiography; Electrophysiologic Techniques, Cardiac; Female; Heart Atria; In Vitro Techniques; Lidocaine; Male; Membrane Potentials; Sodium Channel Blockers

2003
Therapeutic monitoring of class I antiarrhythmic agents using high-resolution electrocardiography instead of blood samples.
    Circulation journal : official journal of the Japanese Circulation Society, 2003, Volume: 67, Issue:3

    Topics: Aged; Anti-Arrhythmia Agents; Drug Monitoring; Electrocardiography; Female; Flecainide; Humans; Lidocaine; Male; Middle Aged; Piperidines

2003
Risk stratification for asymptomatic patients with Brugada syndrome.
    Circulation journal : official journal of the Japanese Circulation Society, 2003, Volume: 67, Issue:4

    Topics: Adult; Aged; Anti-Arrhythmia Agents; Bundle-Branch Block; Cardiac Pacing, Artificial; Electrocardiography; Follow-Up Studies; Heart; Humans; Lidocaine; Male; Middle Aged; Prognosis; Risk Assessment; Ventricular Fibrillation

2003
Effect of pilsicainide on atrial electrophysiologic properties in the canine rapid atrial stimulation model.
    Circulation journal : official journal of the Japanese Circulation Society, 2003, Volume: 67, Issue:4

    Topics: Animals; Anti-Arrhythmia Agents; Atrial Fibrillation; Atrial Function; Cardiac Pacing, Artificial; Diastole; Differential Threshold; Dogs; Electrophysiology; Heart Rate; Lidocaine; Refractory Period, Electrophysiological; Ventricular Function

2003
Enhancement of J-ST-segment elevation by the glucose and insulin test in Brugada syndrome.
    Pacing and clinical electrophysiology : PACE, 2003, Volume: 26, Issue:1P2

    Topics: Adult; Anti-Arrhythmia Agents; Bundle-Branch Block; Electrocardiography; Glucose; Heart Arrest; Humans; Insulin; Lidocaine; Male; Middle Aged; Syncope; Syndrome; Ventricular Fibrillation

2003
Intravenous administration of class I antiarrhythmic drug induced T wave alternans in an asymptomatic Brugada syndrome patient.
    Pacing and clinical electrophysiology : PACE, 2003, Volume: 26, Issue:9

    Topics: Amiodarone; Anti-Arrhythmia Agents; Bundle-Branch Block; Cardiac Pacing, Artificial; Electrocardiography; Electrophysiologic Techniques, Cardiac; Humans; Lidocaine; Male; Middle Aged; Signal Processing, Computer-Assisted; Syndrome; Ventricular Fibrillation

2003
Right bundle branch block and coved-type ST-segment elevation mimicked by acute cholecystitis.
    Circulation journal : official journal of the Japanese Circulation Society, 2003, Volume: 67, Issue:9

    Topics: Aged; Bundle-Branch Block; Cholecystitis, Acute; Diagnosis, Differential; Electrocardiography; Female; Humans; Injections, Intravenous; Lidocaine; Sodium Channel Blockers

2003
Effects of Na+ channel blocker, pilsicainide, on HERG current expressed in HEK-293 cells.
    Journal of cardiovascular pharmacology, 2003, Volume: 42, Issue:3

    Topics: Action Potentials; Cation Transport Proteins; Cells, Cultured; DNA-Binding Proteins; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Humans; Lidocaine; Patch-Clamp Techniques; Potassium Channels; Potassium Channels, Voltage-Gated; Sodium Channel Blockers; Trans-Activators; Transcriptional Regulator ERG

2003
[Factors for successful conversion of atrial fibrillation using intravenous injection of pilsicainide hydrochloride].
    Journal of cardiology, 2003, Volume: 42, Issue:2

    Topics: Aged; Anti-Arrhythmia Agents; Atrial Fibrillation; Electrocardiography; Female; Humans; Injections, Intravenous; Lidocaine; Male; Middle Aged

2003
Ventricular arrhythmia induced by sodium channel blocker in patients with Brugada syndrome.
    Journal of the American College of Cardiology, 2003, Nov-05, Volume: 42, Issue:9

    Topics: Adult; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Bundle-Branch Block; Electrocardiography; Female; Heart Conduction System; Humans; Lidocaine; Male; Middle Aged; Sodium Channel Blockers

2003
[Brugada syndrome associated with ventricular fibrillation induced by administration of pilsicainide: a case report].
    Journal of cardiology, 2003, Volume: 42, Issue:5

    Topics: Anti-Arrhythmia Agents; Atrial Fibrillation; Electrocardiography; Electrophysiology; Humans; Lidocaine; Male; Middle Aged; Syndrome; Ventricular Fibrillation

2003
Mechanism of ST elevation and ventricular arrhythmias in an experimental Brugada syndrome model.
    Circulation, 2004, Jan-06, Volume: 109, Issue:1

    Topics: Animals; Disease Models, Animal; Dogs; Electrocardiography; Female; In Vitro Techniques; Lidocaine; Male; Pinacidil; Potassium Channels; Sodium Channel Blockers; Syndrome; Tachycardia, Ventricular

2004
Brugada-like electrocardiographic pattern unmasked by fever.
    Japanese heart journal, 2004, Volume: 45, Issue:1

    Topics: Adult; Body Temperature; Bundle-Branch Block; Electrocardiography; Fever; Humans; Lidocaine; Male; Sodium Channel Blockers; Sodium Channels; Syndrome

2004
Brugada syndrome-like ST-segment elevation increase exacerbated by vomiting.
    Circulation journal : official journal of the Japanese Circulation Society, 2004, Volume: 68, Issue:7

    Topics: Acetylcholine; Anti-Arrhythmia Agents; Coronary Vessels; Electrocardiography; Humans; Infusions, Intravenous; Lidocaine; Male; Middle Aged; Syndrome; Ventricular Fibrillation; Vomiting

2004
The effects of class Ic antiarrhythmics on tetrodotoxin-resistant Na+ currents in rat sensory neurons.
    Anesthesia and analgesia, 2004, Volume: 99, Issue:2

    Topics: Algorithms; Anesthetics, Local; Animals; Anti-Arrhythmia Agents; Drug Interactions; Drug Resistance; Flecainide; Ganglia, Spinal; Lidocaine; Male; Neurons, Afferent; Rats; Rats, Sprague-Dawley; Sodium Channel Blockers; Sodium Channels; Tetrodotoxin

2004
Differentiation of the electrophysiological effects on the atrial myocardium between the pure Na channel blocker, pilsicainide, and flecainide.
    Cardiovascular drugs and therapy, 2004, Volume: 18, Issue:4

    Topics: Adult; Anti-Arrhythmia Agents; Atrial Flutter; Electrocardiography; Electrophysiologic Techniques, Cardiac; Female; Flecainide; Heart Atria; Heart Conduction System; Heart Ventricles; Humans; Lidocaine; Male; Middle Aged; Myocardium; Prospective Studies; Refractory Period, Electrophysiological; Research Design; Sodium Channel Blockers; Tachycardia, Atrioventricular Nodal Reentry; Tachycardia, Ventricular; Treatment Outcome; Wolff-Parkinson-White Syndrome

2004
Mexiletine protects myocardium during acute ischemia by opening sarcolemmal K-ATP channel: studies in closed-chest acute ischemia model in rabbits.
    Journal of cardiovascular pharmacology, 2004, Volume: 44, Issue:6

    Topics: Acute Disease; Animals; Anti-Arrhythmia Agents; ATP-Binding Cassette Transporters; Disease Models, Animal; Electrocardiography; Hemodynamics; KATP Channels; Lidocaine; Mexiletine; Myocardial Infarction; Myocardial Ischemia; Myocardial Reperfusion Injury; Myocardium; Potassium Channels; Potassium Channels, Inwardly Rectifying; Rabbits; Sarcolemma; Sodium Channel Blockers; Stroke Volume; Ventricular Function, Left

2004
Pilsicainide in breast milk from a mother: comparison with disopyramide and propafenone.
    British journal of clinical pharmacology, 2005, Volume: 59, Issue:1

    Topics: Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Breast Feeding; Disopyramide; Female; Humans; Lidocaine; Milk, Human; Propafenone

2005
Effects of the NA+ channel blocker pilsicainide on the electrophysiologic properties of pulmonary veins in patients with atrial fibrillation.
    Journal of cardiovascular electrophysiology, 2004, Volume: 15, Issue:12

    Topics: Atrial Fibrillation; Electrophysiologic Techniques, Cardiac; Female; Humans; Infusions, Intravenous; Lidocaine; Male; Middle Aged; Pulmonary Veins; Sodium Channel Blockers; Treatment Outcome

2004
A case of the toxicity of pilsicainide hydrochloride with comparison of the serial serum pilsicainide levels and electrocardiographic findings.
    Japanese heart journal, 2004, Volume: 45, Issue:6

    Topics: Aged; Aged, 80 and over; Anti-Arrhythmia Agents; Atrial Fibrillation; Creatinine; Drug Overdose; Electrocardiography; Humans; Lidocaine; Male; Tachycardia, Ventricular

2004
Three elderly cases with Brugada-type electrocardiographic pattern unmasked by pilsicainide at the toxic level.
    Internal medicine (Tokyo, Japan), 2005, Volume: 44, Issue:1

    Topics: Aged; Aged, 80 and over; Anti-Arrhythmia Agents; Electrocardiography; Heart Block; Humans; Kidney Failure, Chronic; Lidocaine; Male

2005
A simple in vivo atrial fibrillation model of rat induced by transesophageal atrial burst pacing.
    Journal of pharmacological sciences, 2005, Volume: 98, Issue:3

    Topics: Animals; Atrial Fibrillation; Cardiac Pacing, Artificial; Disease Models, Animal; Electrocardiography; Lidocaine; Male; Rats; Rats, Sprague-Dawley

2005
Pilsicainide-induced coronary vasospasm in a patient with Brugada-type electrocardiogram.
    Circulation journal : official journal of the Japanese Circulation Society, 2005, Volume: 69, Issue:7

    Topics: Aged; Anti-Arrhythmia Agents; Coronary Angiography; Coronary Vasospasm; Electrocardiography; Heart Arrest; Humans; Injections, Intravenous; Lidocaine; Male

2005
Effect of protein binding of pilsicainide on the pharmacokinetics.
    Drug metabolism and pharmacokinetics, 2005, Volume: 20, Issue:3

    Topics: Aged; Anti-Arrhythmia Agents; C-Reactive Protein; Chromatography, High Pressure Liquid; Creatinine; Humans; Lidocaine; Middle Aged; Orosomucoid; Protein Binding

2005
Effect of sodium channel blocker, pilsicainide hydrochloride, on net inward current of atrial myocytes in thyroid hormone toxicosis rats.
    Thyroid : official journal of the American Thyroid Association, 2005, Volume: 15, Issue:7

    Topics: Action Potentials; Animals; Arrhythmias, Cardiac; Electrocardiography; Heart Atria; Lidocaine; Male; Myocytes, Cardiac; Rats; Rats, Sprague-Dawley; Sodium; Sodium Channel Blockers; Thyrotoxicosis; Thyroxine

2005
Long-term efficacy of hybrid pharmacologic and ablation therapy in patients with pilsicainide-induced atrial flutter.
    Clinical cardiology, 2005, Volume: 28, Issue:7

    Topics: Aged; Anti-Arrhythmia Agents; Atrial Fibrillation; Atrial Flutter; Cardiac Pacing, Artificial; Catheter Ablation; Combined Modality Therapy; Dose-Response Relationship, Drug; Electrocardiography; Electrophysiologic Techniques, Cardiac; Female; Follow-Up Studies; Humans; Lidocaine; Male; Middle Aged; Prospective Studies; Sodium Channel Blockers; Treatment Outcome

2005
Heart rate variability is a useful parameter for evaluation of anticholinergic effect associated with inducibility of atrial fibrillation.
    Pacing and clinical electrophysiology : PACE, 2005, Volume: 28, Issue:11

    Topics: Animals; Anti-Arrhythmia Agents; Atrial Fibrillation; Cholinergic Antagonists; Disopyramide; Dogs; Electrocardiography; Heart Atria; Heart Conduction System; Heart Rate; Lidocaine; Treatment Outcome

2005
[Case in which magnesium sulfate effectively treated ventricular tachycardia due to overdose of pilsicainide hydrochloride].
    Chudoku kenkyu : Chudoku Kenkyukai jun kikanshi = The Japanese journal of toxicology, 2006, Volume: 19, Issue:1

    Topics: Adult; Anti-Asthmatic Agents; Drug Overdose; Hemoperfusion; Humans; Infusions, Intravenous; Lidocaine; Magnesium Sulfate; Male; Suicide, Attempted; Tachycardia, Ventricular; Treatment Outcome

2006
Pilsicainide-induced verapamil sensitive idiopathic left ventricular tachycardia.
    Pacing and clinical electrophysiology : PACE, 2006, Volume: 29, Issue:5

    Topics: Adult; Anti-Arrhythmia Agents; Drug Combinations; Electrocardiography; Humans; Lidocaine; Male; Tachycardia, Ventricular; Ventricular Dysfunction, Left; Verapamil

2006
Cellular basis for trigger and maintenance of ventricular fibrillation in the Brugada syndrome model: high-resolution optical mapping study.
    Journal of the American College of Cardiology, 2006, May-16, Volume: 47, Issue:10

    Topics: Action Potentials; Animals; Cardiovascular Agents; Disease Models, Animal; Dogs; Electrocardiography; Electrophysiologic Techniques, Cardiac; Endocardium; Heart Conduction System; Heart Diseases; Heart Ventricles; Lidocaine; Male; Pericardium; Pinacidil; Tachycardia, Ventricular; Terfenadine; Ventricular Fibrillation

2006
The full stomach test as a novel diagnostic technique for identifying patients at risk of Brugada syndrome.
    Journal of cardiovascular electrophysiology, 2006, Volume: 17, Issue:6

    Topics: Adult; Brugada Syndrome; Circadian Rhythm; Electrocardiography; Electrophysiologic Techniques, Cardiac; Female; Heart; Humans; Lidocaine; Male; Middle Aged; Postprandial Period; Predictive Value of Tests; Sodium Channel Blockers; Stomach; Syncope; Vagus Nerve; Ventricular Fibrillation

2006
Effects of antiarrhythmic drugs on apoptotic pathways in H9c2 cardiac cells.
    Journal of pharmacological sciences, 2006, Volume: 101, Issue:4

    Topics: Amiodarone; Animals; Anti-Arrhythmia Agents; Apoptosis; Caspases; Cell Line; Clone Cells; Diploidy; DNA Fragmentation; Dose-Response Relationship, Drug; Lidocaine; Membrane Potentials; Mitochondrial Membranes; Propranolol; Pyrimidinones; Signal Transduction; Time Factors; Verapamil

2006
Spontaneous polymorphic ventricular tachycardia after administration of pilsicainide in a patient resuscitated from ventricular fibrillation.
    Pacing and clinical electrophysiology : PACE, 2006, Volume: 29, Issue:9

    Topics: Adult; Anti-Arrhythmia Agents; Cardiopulmonary Resuscitation; Electric Countershock; Humans; Lidocaine; Tachycardia, Ventricular; Ventricular Fibrillation

2006
High-frequency potentials developed in wavelet-transformed electrocardiogram as a novel indicator for detecting Brugada syndrome.
    Heart rhythm, 2006, Volume: 3, Issue:12

    Topics: Action Potentials; Adrenergic beta-Agonists; Adult; Aged; Anti-Arrhythmia Agents; Brugada Syndrome; Cilostazol; Electrocardiography; Heart Conduction System; Humans; Isoproterenol; Lidocaine; Male; Middle Aged; Research Design; Tetrazoles; Time Factors; Vasodilator Agents

2006
Comment on severe arrhythmia as a result of the interaction of cetirizine and pilsicainide in a patient with renal insufficiency.
    Clinical pharmacology and therapeutics, 2006, Volume: 80, Issue:6

    Topics: Aged; Area Under Curve; Arrhythmias, Cardiac; Cetirizine; Drug Interactions; Female; Half-Life; Humans; Lidocaine; Metabolic Clearance Rate; Renal Insufficiency

2006
Multiple premature beats triggered ventricular arrhythmias during pilsicainide infusion in a patient with inferior ST-segment elevation.
    Pacing and clinical electrophysiology : PACE, 2006, Volume: 29, Issue:12

    Topics: Adolescent; Anti-Arrhythmia Agents; Atrial Flutter; Electrocardiography; Humans; Infusions, Intravenous; Lidocaine; Male; Ventricular Fibrillation; Ventricular Premature Complexes

2006
Temperature modulation of ventricular arrhythmogenicity in a canine tissue model of Brugada syndrome.
    Heart rhythm, 2007, Volume: 4, Issue:2

    Topics: Action Potentials; Animals; Body Temperature; Brugada Syndrome; Disease Models, Animal; Dogs; Electrocardiography; Fever; Hypothermia, Induced; Lidocaine; Ventricular Dysfunction

2007
How can a single mutation cause such arrhythmic havoc?
    Heart rhythm, 2007, Volume: 4, Issue:2

    Topics: Action Potentials; Animals; Body Temperature; Brugada Syndrome; Disease Models, Animal; Dogs; Electrocardiography; Fever; Hypothermia, Induced; Ion Channels; Lidocaine; Mutation; Ventricular Dysfunction

2007
Pilsicainide-induced ventricular tachycardia originating from right ventricular outflow tract.
    Journal of cardiovascular electrophysiology, 2007, Volume: 18, Issue:5

    Topics: Anti-Arrhythmia Agents; Atrial Fibrillation; Female; Humans; Lidocaine; Middle Aged; Tachycardia, Ventricular

2007
Incidence and initial characteristics of pilsicainide-induced ventricular arrhythmias in patients with Brugada syndrome.
    Pacing and clinical electrophysiology : PACE, 2007, Volume: 30, Issue:5

    Topics: Adult; Aged; Arrhythmias, Cardiac; Brugada Syndrome; Electrocardiography; Electrophysiologic Techniques, Cardiac; Female; Humans; Incidence; Lidocaine; Male; Middle Aged; Sodium Channel Blockers

2007
[Elderly Brugada syndrome with recurrent syncope, diagnosed by pilsicainide challenge test].
    Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine, 2007, Jun-10, Volume: 96, Issue:6

    Topics: Aged; Brugada Syndrome; Electrocardiography; Humans; Lidocaine; Male; Recurrence; Syncope

2007
Mechanisms of the preventive effect of pilsicainide on atrial fibrillation originating from the pulmonary vein.
    Circulation journal : official journal of the Japanese Circulation Society, 2007, Volume: 71, Issue:11

    Topics: Acetylcholine; Action Potentials; Animals; Anti-Arrhythmia Agents; Atrial Fibrillation; Dogs; Electric Stimulation; Electroencephalography; Heart Atria; Lidocaine; Male; Pulmonary Veins; Vagus Nerve; Vasodilator Agents

2007
Pilsicainide-induced Brugada-type ECG and ventricular arrhythmias originating from the left posterior fascicle in a case with Brugada syndrome associated with idiopathic left ventricular tachycardia.
    Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology, 2008, Volume: 10, Issue:1

    Topics: Anti-Arrhythmia Agents; Brugada Syndrome; Catheter Ablation; Electrocardiography; Electrophysiologic Techniques, Cardiac; Humans; Lidocaine; Male; Middle Aged; Tachycardia, Ventricular; Ventricular Septum

2008
Clinical and electrophysiological characteristics of patients having atrial flutter with 1:1 atrioventricular conduction.
    Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology, 2008, Volume: 10, Issue:3

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Amiodarone; Anti-Arrhythmia Agents; Atrial Flutter; Case-Control Studies; Catheter Ablation; Electrocardiography; Electrophysiologic Techniques, Cardiac; Female; Flecainide; Heart Atria; Heart Conduction System; Heart Ventricles; Humans; Imidazoles; Lidocaine; Male; Middle Aged; Retrospective Studies; Risk Factors

2008
Re: Clinical significance of macroscopic T-wave alternans after sodium channel blocker administration in patients with Brugada syndrome.
    Journal of cardiovascular electrophysiology, 2008, Volume: 19, Issue:4

    Topics: Brugada Syndrome; Electrocardiography; Female; Humans; Lidocaine; Male; Middle Aged; Sodium Channel Blockers; Ventricular Fibrillation

2008
Longer repolarization in the epicardium at the right ventricular outflow tract causes type 1 electrocardiogram in patients with Brugada syndrome.
    Journal of the American College of Cardiology, 2008, Mar-25, Volume: 51, Issue:12

    Topics: Action Potentials; Adult; Aged; Brugada Syndrome; Case-Control Studies; Electrocardiography; Endocardium; Female; Heart Conduction System; Heart Ventricles; Humans; Lidocaine; Male; Middle Aged; Pericardium; Sodium Channel Blockers

2008
Menstruation-dependent idiopathic ventricular arrhythmia.
    Gender medicine, 2008, Volume: 5, Issue:2

    Topics: Adult; Anti-Asthmatic Agents; Electrocardiography, Ambulatory; Female; Humans; Lidocaine; Menstruation; Propranolol; Ventricular Premature Complexes

2008
Acute fatal poisoning with pilsicainide and atenolol.
    International journal of legal medicine, 2008, Volume: 122, Issue:6

    Topics: Adrenergic beta-Antagonists; Adult; Atenolol; Chromatography, High Pressure Liquid; Depression; Female; Fibrosis; Forensic Pathology; Forensic Toxicology; Gas Chromatography-Mass Spectrometry; Humans; Lidocaine; Lung; Myocytes, Cardiac; Nephritis, Interstitial; Pulmonary Edema; Sodium Channel Blockers; Suicide; Young Adult

2008
Action potential alternans in the right ventricular outflow tract in a patient with asymptomatic Brugada syndrome.
    Circulation journal : official journal of the Japanese Circulation Society, 2009, Volume: 73, Issue:3

    Topics: Action Potentials; Aged; Anti-Arrhythmia Agents; Brugada Syndrome; Electrocardiography; Humans; Lidocaine; Male; Ventricular Fibrillation; Ventricular Function, Right

2009
Pilsicainide intoxication presenting as left ventricular dyssynchrony in a patient on hemodialysis.
    Journal of cardiology, 2009, Volume: 53, Issue:1

    Topics: Aged; Anti-Arrhythmia Agents; Diagnosis, Differential; Humans; Lidocaine; Male; Renal Dialysis; Ventricular Dysfunction, Left

2009
Effect of pilsicainide on dominant frequency in the right and left atria and pulmonary veins during atrial fibrillation: association with its atrial fibrillation terminating effect.
    European journal of pharmacology, 2009, Apr-17, Volume: 608, Issue:1-3

    Topics: Aged; Anti-Arrhythmia Agents; Atrial Fibrillation; Catheter Ablation; Echocardiography; Electrophysiologic Techniques, Cardiac; Fasting; Female; Heart Atria; Humans; Lidocaine; Male; Middle Aged; Pulmonary Veins; Treatment Outcome

2009
Early termination of spiral wave reentry by combined blockade of Na+ and L-type Ca2+ currents in a perfused two-dimensional epicardial layer of rabbit ventricular myocardium.
    Heart rhythm, 2009, Volume: 6, Issue:5

    Topics: Animals; Calcium Channel Blockers; Calcium Channels, L-Type; Disease Models, Animal; Electrophysiologic Techniques, Cardiac; Heart Rate; Heart Ventricles; Lidocaine; Pericardium; Rabbits; Sodium Channel Blockers; Sodium Channels; Tachycardia, Sinoatrial Nodal Reentry; Treatment Outcome; Verapamil

2009
Mapping ventricular fibrillation: a simplified experimental model leads to a complicated result.
    Heart rhythm, 2009, Volume: 6, Issue:5

    Topics: Animals; Calcium Channel Blockers; Calcium Channels, L-Type; Disease Models, Animal; Electrophysiologic Techniques, Cardiac; Heart Rate; Heart Ventricles; Lidocaine; Pericardium; Rabbits; Sodium Channel Blockers; Sodium Channels; Tachycardia, Ventricular; Treatment Outcome; Verapamil

2009
Ischemia-induced Brugada-type ST-segment alternans and Brugada syndrome.
    International journal of cardiology, 2010, Oct-29, Volume: 144, Issue:3

    Topics: Adult; Aged; Angioplasty, Balloon, Coronary; Brugada Syndrome; Bundle-Branch Block; Coronary Artery Disease; Diagnosis, Differential; Electrocardiography; Female; Heart Conduction System; Humans; Lidocaine; Male; Middle Aged; Myocardial Ischemia; Prospective Studies; Sodium Channel Blockers

2010
Pilsicainide-induced ST segment elevation and ST segment depression in two patients with variant forms of Brugada-type electrocardiographic abnormalities.
    Pacing and clinical electrophysiology : PACE, 2009, Volume: 32, Issue:6

    Topics: Adolescent; Adult; Anti-Arrhythmia Agents; Brugada Syndrome; Electrocardiography; Humans; Injections, Intravenous; Lidocaine; Male; Ventricular Premature Complexes

2009
Simultaneous assessment of pharmacokinetics of pilsicainide transdermal patch and its electropharmacological effects on atria of chronic atrioventricular block dogs.
    Journal of pharmacological sciences, 2009, Volume: 110, Issue:3

    Topics: Administration, Cutaneous; Animals; Anti-Arrhythmia Agents; Atrial Fibrillation; Atrioventricular Block; Dogs; Female; Heart Atria; Lidocaine; Male

2009
A predictor of positive drug provocation testing in individuals with saddle-back type ST-segment elevation.
    Circulation journal : official journal of the Japanese Circulation Society, 2009, Volume: 73, Issue:10

    Topics: Action Potentials; Adult; Brugada Syndrome; Electrocardiography; Female; Humans; Infusions, Intravenous; Lidocaine; Male; Middle Aged; Predictive Value of Tests; ROC Curve; Sensitivity and Specificity; Sodium Channel Blockers; Time Factors

2009
Ventricular late potential in patients with apparently normal electrocardiogram; predictor of Brugada syndrome.
    Pacing and clinical electrophysiology : PACE, 2010, Volume: 33, Issue:3

    Topics: Adult; Aged; Aged, 80 and over; Brugada Syndrome; Chi-Square Distribution; Electrocardiography; Female; Humans; Lidocaine; Male; Middle Aged; Predictive Value of Tests; Retrospective Studies; ROC Curve; Sodium Channel Blockers; Statistics, Nonparametric; Syncope; Ventricular Premature Complexes

2010
Conduction delay in right ventricle as a marker for identifying high-risk patients with Brugada syndrome.
    Journal of cardiovascular electrophysiology, 2010, Jun-01, Volume: 21, Issue:6

    Topics: Adult; Anti-Arrhythmia Agents; Brugada Syndrome; Coronary Sinus; Death, Sudden, Cardiac; Electrocardiography; Electrophysiology; Female; Heart Conduction System; Humans; Lidocaine; Male; Middle Aged; Observer Variation; Risk Assessment; Sodium Channel Blockers; Ventricular Function, Right

2010
A novel microsatellite polymorphism of sodium channel beta1-subunit gene (SCN1B) may underlie abnormal cardiac excitation manifested by coved-type ST-elevation compatible with Brugada syndrome in Japanese.
    International journal of clinical pharmacology and therapeutics, 2010, Volume: 48, Issue:2

    Topics: Adult; Age Factors; Aged; Asian People; Brugada Syndrome; Electrocardiography; Female; Genetic Predisposition to Disease; Humans; Japan; Lidocaine; Logistic Models; Male; Microsatellite Repeats; Middle Aged; Muscle Proteins; Mutation; NAV1.5 Voltage-Gated Sodium Channel; Nerve Tissue Proteins; Polymorphism, Genetic; Risk Factors; Sex Factors; Sodium Channel Blockers; Sodium Channels; Voltage-Gated Sodium Channel beta-1 Subunit; Voltage-Gated Sodium Channel beta-2 Subunit

2010
Genotype-phenotype correlation in tissue models of Brugada syndrome simulating patients with sodium and calcium channelopathies.
    Heart rhythm, 2010, Volume: 7, Issue:6

    Topics: Action Potentials; Adrenergic beta-Agonists; Animals; Anti-Arrhythmia Agents; Body Surface Potential Mapping; Brugada Syndrome; Calcium Channel Blockers; Channelopathies; Dogs; Endocardium; Genotype; Isoproterenol; Lidocaine; Male; Pericardium; Phenotype; Pinacidil; Sodium Channels; Tissue Culture Techniques; Vasodilator Agents; Verapamil

2010
What variables were associated with the inducibility of ventricular fibrillation during electrophysiologic stimulation test in patients without apparent organic heart disease?
    Journal of cardiology, 2010, Volume: 56, Issue:1

    Topics: Brugada Syndrome; Electric Stimulation; Electrocardiography; Female; Humans; Lidocaine; Male; Middle Aged; Sodium Channel Blockers; Ventricular Fibrillation

2010
Ventricular fibrillation diagnosed during electrophysiological study for non-sustained tachycardia.
    Aviation, space, and environmental medicine, 2010, Volume: 81, Issue:6

    Topics: Adult; Anti-Arrhythmia Agents; Brugada Syndrome; Electrocardiography; Humans; Japan; Lidocaine; Male; Occupational Health; Tachycardia, Ventricular; Time Factors; Ventricular Fibrillation

2010
Molecular determinants of state-dependent block of voltage-gated sodium channels by pilsicainide.
    British journal of pharmacology, 2010, Volume: 160, Issue:6

    Topics: Brain; Cell Line; Flecainide; Heart; Humans; Lidocaine; Mexiletine; Muscle Proteins; Muscle, Skeletal; NAV1.1 Voltage-Gated Sodium Channel; NAV1.4 Voltage-Gated Sodium Channel; NAV1.5 Voltage-Gated Sodium Channel; Nerve Tissue Proteins; Patch-Clamp Techniques; Sodium Channel Blockers; Sodium Channels

2010
Comparison of acute reduction in left ventricular outflow tract pressure gradient in obstructive hypertrophic cardiomyopathy by disopyramide versus pilsicainide versus cibenzoline.
    The American journal of cardiology, 2010, Nov-01, Volume: 106, Issue:9

    Topics: Adult; Aged; Anti-Arrhythmia Agents; Cardiomyopathy, Hypertrophic; Disopyramide; Echocardiography, Doppler; Female; Humans; Imidazoles; Lidocaine; Linear Models; Male; Middle Aged; Propranolol; Prospective Studies; Treatment Outcome; Ventricular Dysfunction, Left; Ventricular Pressure; Verapamil

2010
[Two elderly case reports of renal excretion type drug poisoning caused by dehydration that was due to poor eating in home care].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2010, Volume: 37 Suppl 2

    Topics: Acute Kidney Injury; Aged; Aged, 80 and over; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Dehydration; Feeding and Eating Disorders; Female; Home Care Services; Humans; Lidocaine; Palliative Care; Rectal Neoplasms

2010
A new criteria differentiating type 2 and 3 Brugada patterns from ordinary incomplete right bundle branch block.
    International heart journal, 2011, Volume: 52, Issue:3

    Topics: Adult; Anti-Arrhythmia Agents; Brugada Syndrome; Bundle-Branch Block; Diagnosis, Differential; Electrocardiography; Female; Humans; Lidocaine; Male; Middle Aged

2011
A sodium channel blocker, pilsicainide, produces atrial post-repolarization refractoriness through the reduction of sodium channel availability.
    The Tohoku journal of experimental medicine, 2011, Volume: 225, Issue:1

    Topics: Action Potentials; Animals; Guinea Pigs; Heart Atria; In Vitro Techniques; Kinetics; Lidocaine; Male; Refractory Period, Electrophysiological; Sodium Channel Blockers; Sodium Channels; Tetrodotoxin

2011
Right ventricular dysfunction in patients with Brugada-like electrocardiography: a two dimensional strain imaging study.
    Cardiovascular ultrasound, 2011, Nov-16, Volume: 9

    Topics: Brugada Syndrome; Echocardiography; Elasticity Imaging Techniques; Electrocardiography; Female; Humans; Lidocaine; Male; Middle Aged; Reproducibility of Results; Sensitivity and Specificity; Sodium Channel Blockers; Ventricular Dysfunction, Right

2011
Pilsicainide-induced polymorphic ventricular tachycardia.
    Internal medicine (Tokyo, Japan), 2012, Volume: 51, Issue:4

    Topics: Aged, 80 and over; Anti-Arrhythmia Agents; Electrocardiography; Female; Humans; Lidocaine; Tachycardia, Ventricular

2012
Rate-dependent and site-specific conduction block at the posterior right atrium and drug effects evaluated using a noncontact mapping system in patients with typical atrial flutter.
    Journal of cardiovascular electrophysiology, 2012, Volume: 23, Issue:8

    Topics: Action Potentials; Adult; Aged; Aged, 80 and over; Anti-Arrhythmia Agents; Atrial Flutter; Cardiac Pacing, Artificial; Catheter Ablation; Electrophysiologic Techniques, Cardiac; Female; Heart Atria; Heart Block; Heart Conduction System; Humans; Lidocaine; Male; Middle Aged; Predictive Value of Tests; Sodium Channel Blockers; Time Factors; Voltage-Sensitive Dye Imaging

2012
Electrophysiological effects of the class Ic antiarrhythmic drug pilsicainide on the guinea-pig pulmonary vein myocardium.
    Journal of pharmacological sciences, 2012, Volume: 118, Issue:4

    Topics: Animals; Anti-Arrhythmia Agents; Atrial Function, Left; Electrophysiological Phenomena; Female; Guinea Pigs; Heart Atria; Lidocaine; Male; Myocardium; Pulmonary Veins; Treatment Outcome

2012
Pharmacologic atrial defibrillation by drug delivery into the temporarily occluded coronary sinus. A canine study.
    International heart journal, 2012, Volume: 53, Issue:2

    Topics: Animals; Anti-Arrhythmia Agents; Atrial Fibrillation; Balloon Occlusion; Cardiac Pacing, Artificial; Chronic Disease; Coronary Sinus; Dogs; Drug Delivery Systems; Injections, Intravenous; Lidocaine; Pyrimidinones; Treatment Outcome

2012
Cardiohemodynamic and electrophysiological effects of anti-influenza drug oseltamivir in vivo and in vitro.
    Cardiovascular toxicology, 2013, Volume: 13, Issue:3

    Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Antiviral Agents; Arterial Pressure; Cardiac Pacing, Artificial; Coronary Circulation; Dogs; Electrocardiography; Female; Guinea Pigs; Heart Atria; Hemodynamics; Humans; In Vitro Techniques; Influenza, Human; Lidocaine; Male; Myocardial Contraction; Oseltamivir; Refractory Period, Electrophysiological

2013
Electrophysiological effects of an anti-influenza drug oseltamivir on the guinea-pig atrium: comparison with those of pilsicainide.
    Biological & pharmaceutical bulletin, 2013, Volume: 36, Issue:10

    Topics: Animals; Anti-Arrhythmia Agents; Antiviral Agents; Atrial Fibrillation; Atrial Function; Atrial Function, Left; Atrial Function, Right; Electrophysiological Phenomena; Guinea Pigs; Heart Atria; Humans; Influenza, Human; Lidocaine; Oseltamivir; Potassium Channel Blockers; Refractory Period, Electrophysiological; Sodium Channel Blockers

2013
Altered responses to vasopressors of a patient medicated with carvedilol, pilsicainide and enalapril.
    Journal of anesthesia, 2014, Volume: 28, Issue:4

    Topics: Adrenergic beta-Antagonists; Angiotensin-Converting Enzyme Inhibitors; Anti-Arrhythmia Agents; Atrial Fibrillation; Carbazoles; Carvedilol; Drug Interactions; Enalapril; Humans; Hypotension; Lidocaine; Male; Middle Aged; Propanolamines; Vasoconstrictor Agents

2014
Idiopathic ventricular fibrillation associated with early repolarization which was unmasked by a sodium channel blocker after catheter ablation of atrial fibrillation.
    Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing, 2014, Volume: 41, Issue:2

    Topics: Atrial Fibrillation; Catheter Ablation; Electrocardiography; Female; Follow-Up Studies; Humans; Injections, Intravenous; Isoproterenol; Lidocaine; Middle Aged; Risk Assessment; Sodium Channel Blockers; Treatment Outcome; Ventricular Fibrillation

2014
Quantitation of pilsicainide in microscale samples of human biological fluids using liquid chromatography-tandem mass spectrometry.
    Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2015, Mar-15, Volume: 985

    Topics: Adult; Chromatography, Liquid; Drug Monitoring; Humans; Lidocaine; Linear Models; Male; Reproducibility of Results; Sensitivity and Specificity; Tandem Mass Spectrometry; Young Adult

2015
Significance of electrocardiogram recording in high intercostal spaces in patients with early repolarization syndrome.
    European heart journal, 2016, Feb-14, Volume: 37, Issue:7

    Topics: Adult; Anti-Arrhythmia Agents; Brugada Syndrome; Electrocardiography; Electrophysiologic Techniques, Cardiac; Female; Flecainide; Humans; Lidocaine; Male; Prognosis; Recurrence; Risk Assessment; Ventricular Fibrillation

2016
Right coronary cusp as a new window of ablation for pilsicainide-induced ventricular premature contractions in a patient with Brugada syndrome.
    Heart and vessels, 2016, Volume: 31, Issue:8

    Topics: Adult; Brugada Syndrome; Electrocardiography; Electrophysiologic Techniques, Cardiac; Heart Ventricles; Humans; Lidocaine; Male; Pericardium; Sodium Channel Blockers; Ventricular Premature Complexes

2016
A Novel SCN5A Mutation Associated with Drug Induced Brugada Type ECG.
    PloS one, 2016, Volume: 11, Issue:8

    Topics: Aged; Anti-Arrhythmia Agents; Atrial Fibrillation; Atrial Flutter; Base Sequence; Brugada Syndrome; DNA Mutational Analysis; Electrocardiography; HEK293 Cells; Humans; Lidocaine; Male; Mutation, Missense; NAV1.5 Voltage-Gated Sodium Channel

2016
Characterization of microminipigs as an in vivo experimental model for cardiac safety pharmacology.
    Journal of pharmacological sciences, 2017, Volume: 133, Issue:2

    Topics: Animals; Anti-Arrhythmia Agents; Blood Pressure; Cardiovascular Physiological Phenomena; Electrocardiography; Heart; Heart Rate; Infusions, Intravenous; Lidocaine; Piperidines; Pyridines; Swine; Swine, Miniature; Verapamil

2017
Utility of 12-lead and signal-averaged Holter electrocardiograms after pilsicainide provocation for risk stratification in Brugada syndrome.
    Heart and vessels, 2017, Volume: 32, Issue:9

    Topics: Anti-Arrhythmia Agents; Brugada Syndrome; Electrocardiography, Ambulatory; Female; Humans; Lidocaine; Male; Middle Aged; Retrospective Studies; Risk Assessment; Risk Factors; ROC Curve; Ventricular Fibrillation

2017
Inhibitory effects of local anesthetics on the proteasome and their biological actions.
    Scientific reports, 2017, 07-11, Volume: 7, Issue:1

    Topics: Anesthetics, Local; Animals; Cattle; Cell Line, Tumor; Cell Proliferation; Humans; Leupeptins; Lidocaine; Molecular Docking Simulation; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Protein Stability

2017
Prognostic Significance of the Sodium Channel Blocker Test in Patients With Brugada Syndrome.
    Journal of the American Heart Association, 2018, 05-10, Volume: 7, Issue:10

    Topics: Administration, Intravenous; Adult; Aged; Brugada Syndrome; Death, Sudden, Cardiac; Electrocardiography; Female; Humans; Lidocaine; Male; Middle Aged; Predictive Value of Tests; Progression-Free Survival; Risk Assessment; Risk Factors; Sodium Channel Blockers; Tachycardia, Ventricular; Time Factors; Ventricular Fibrillation

2018
Successful treatment for various arrhythmias in an older patient treated with pilsicainide for paroxysmal supraventricular tachycardia.
    Geriatrics & gerontology international, 2018, Volume: 18, Issue:10

    Topics: Aged, 80 and over; Anti-Arrhythmia Agents; Electrocardiography; Female; Humans; Lidocaine; Tachycardia, Paroxysmal; Tachycardia, Supraventricular

2018
Clinical and Electrocardiographic Differences in Brugada Syndrome With Spontaneous or Drug-Induced Type 1 Electrocardiogram.
    Circulation journal : official journal of the Japanese Circulation Society, 2019, 02-25, Volume: 83, Issue:3

    Topics: Adult; Anti-Arrhythmia Agents; Brugada Syndrome; Electrocardiography; Female; Humans; Lidocaine; Male; Middle Aged; Prognosis; Ventricular Fibrillation

2019
Pilsicainide Administration Unmasks a Phenotype of Brugada Syndrome in a Patient with Overlap Syndrome due to the E1784K SCN5A Mutation.
    Internal medicine (Tokyo, Japan), 2020, Jan-01, Volume: 59, Issue:1

    Topics: Adult; Anti-Arrhythmia Agents; Brugada Syndrome; Electrocardiography; Humans; Lidocaine; Long QT Syndrome; Male; Mutation; NAV1.5 Voltage-Gated Sodium Channel; Phenotype; Ventricular Fibrillation

2020
Involvement of the persistent Na
    Journal of pharmacological sciences, 2019, Volume: 141, Issue:1

    Topics: Action Potentials; Animals; Atrial Fibrillation; Cells, Cultured; Diastole; Guinea Pigs; Lidocaine; Male; Membrane Potentials; Myocytes, Cardiac; Pulmonary Veins; Pyridines; Sodium; Tetrodotoxin; Triazoles

2019
Development of Pulmonary Edema Despite Negative Fluid Balance with Diuretics in a Patient with Heart Failure and Sigmoid Septum.
    The Tokai journal of experimental and clinical medicine, 2020, Apr-20, Volume: 45, Issue:1

    Topics: Aged, 80 and over; Diuretics; Furosemide; Heart Failure; Humans; Lidocaine; Male; Pulmonary Edema; Ventricular Outflow Obstruction; Ventricular Septum

2020
Concurrent increases in post-pacing action potential duration and contractility predict occurrence of ventricular arrhythmia.
    Pflugers Archiv : European journal of physiology, 2020, Volume: 472, Issue:12

    Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Heart; Heart Rate; Lidocaine; Male; Myocardial Contraction; Phenylurea Compounds; Pinacidil; Rabbits; Sodium Channel Blockers; Tachycardia, Ventricular; Tetrazoles

2020
Efficacy of a Subcutaneous Implantable Cardioverter Defibrillator in a Child with Early Repolarization Syndrome.
    International heart journal, 2021, Jul-30, Volume: 62, Issue:4

    Topics: Anti-Arrhythmia Agents; Child; Death, Sudden, Cardiac; Defibrillators, Implantable; Electrocardiography; Humans; Lidocaine; Male; Ventricular Fibrillation

2021
Pilsicainide intoxication mimicking hyperkalemia effectively managed by prompt diagnosis and emergency haemodialysis.
    BMJ case reports, 2022, 10-13, Volume: 15, Issue:10

    Topics: Anti-Arrhythmia Agents; Humans; Hyperkalemia; Lidocaine; Poisoning; Renal Dialysis

2022
Negative Inotropic Effects of Class I Antiarrhythmics on Guinea Pig Ventricular Myocardium: Correlation with L-Type Ca
    Biological & pharmaceutical bulletin, 2023, Volume: 46, Issue:1

    Topics: Animals; Anti-Arrhythmia Agents; Guinea Pigs; Lidocaine; Myocardium; Papillary Muscles; Propafenone

2023
Cardiac Arrest Due to Pacing Failure From Pilsicainide Poisoning.
    Anesthesia progress, 2023, 06-01, Volume: 70, Issue:2

    Topics: Anti-Arrhythmia Agents; Heart Arrest; Humans; Lidocaine

2023