Page last updated: 2024-08-16

pilsicainide and flecainide

pilsicainide has been researched along with flecainide in 26 studies

Research

Studies (26)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's12 (46.15)18.2507
2000's11 (42.31)29.6817
2010's3 (11.54)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Sen, S; Sinha, N1
Arita, M; Kiyosue, T; Sato, T; Wu, B1
Kato, R; Koide, M; Miyahara, T; Sotobata, I; Toyama, J; Ukai, M; Yasui, S; Yokota, M1
Ikeda, N; Kamiya, K1
Akaike, N; Inomata, N; Ishihara, T1
Higuchi, M; Itomine, T; Matsuzaki, T; Nakasone, J; Noguchi, K; Ojiri, Y; Sakanashi, M; Shiroma, N1
Liu, JX; Ohtsuka, Y; Sakai, Y; Takeo, S; Tanonaka, K1
Asayama, J; Inoue, D; Inoue, M; Ishibashi, K; Nakagawa, M; Omori, I; Sakai, R; Yamahara, Y1
Akaike, N; Inomata, N; Ishihara, T; Ohno, T1
Hatakeyama, N; Inoko, M; Kihara, Y; Momose, Y; Sasayama, S1
Annoura, M; Arakawa, K; Ideishi, M; Kumagai, K; Matsuo, K1
Ito, H; Nakamura, W; Segawa, K; Tanaka, S; Yoshimoto, N1
Fujiki, A; Hayashi, H; Inoue, H; Mizumaki, K; Nagasawa, H; Usui, M1
Kawano, Y; Mineda, Y; Nakata, Y; Nakazato, K; Nakazato, Y; Sekita, G; Sumiyoshi, M; Tokano, T; Yamashita, H; Yasuda, M1
Azegami, K; Hiejima, K; Hirao, K; Horikawa, T; Kawabata, M; Motokawa, K; Suzuki, F; Suzuki, K1
Imai, H; Matoba, Y; Nakagawa, M; Shiraishi, H; Shirayama, T; Yoshida, S1
Hara, H; Ikeda-Murakami, K; Inuo, K; Izumi, T; Kojima, J; Niwano, S; Saito, J; Yoshida, T2
Katoh, T; Ono, T; Sutovsky, I; Takano, T; Takayama, H1
Kubota, I; Nagai, S; Takeishi, Y1
Dohi, S; Iida, H; Oda, A; Osawa, Y; Tanahashi, S1
Esato, M; Inoue, N; Kakugawa, H; Kametani, R; Kanemoto, M; Matsuzaki, M; Sawa, A; Shimizu, A; Ueyama, T; Yamagata, T; Yoshiga, Y1
Furukawa, T; Hachiya, H; Higuchi, K; Hirao, K; Isobe, M; Kawabata, M; Okada, H; Sasaki, T1
Aoyama, H; Enomoto, M; Hirayama, A; Imai, S; Kushiro, T; Saito, F; Takase, H; Yagi, H; Yamaji, S; Yokoyama, K1
Bruno, C; Conte Camerino, D; Costanza, T; Desaphy, JF; Dipalma, A; Franchini, C; George, A; Lentini, G1
Aiba, T; Ishibashi, K; Kamakura, S; Kamakura, T; Kimura, T; Kusano, K; Makiyama, T; Miyamoto, K; Nakajima, I; Noda, T; Ogawa, H; Okamura, H; Shimizu, W; Takaki, H; Wada, M; Yasuda, S1

Trials

4 trial(s) available for pilsicainide and flecainide

ArticleYear
Mechanism of antiarrhythmic effects of class Ic drugs in paroxysmal atrial fibrillation in man.
    Cardiology, 1998, Volume: 89, Issue:2

    Topics: Administration, Oral; Adult; Aged; Anti-Arrhythmia Agents; Atrial Fibrillation; Cardiac Pacing, Artificial; Electrocardiography; Electrophysiology; Female; Flecainide; Humans; Lidocaine; Male; Middle Aged

1998
Bepridil prevents paroxysmal atrial fibrillation by a class III antiarrhythmic drug effect.
    Pacing and clinical electrophysiology : PACE, 2003, Volume: 26, Issue:1P2

    Topics: Anti-Arrhythmia Agents; Atrial Fibrillation; Bepridil; Electrocardiography; Female; Flecainide; Humans; Lidocaine; Male; Middle Aged

2003
Low-dose flecainide infusion followed by oral pilsicainide is highly effective and safe for paroxysmal atrial fibrillation.
    Cardiovascular drugs and therapy, 2003, Volume: 17, Issue:1

    Topics: Anti-Arrhythmia Agents; Atrial Fibrillation; Drug Therapy, Combination; Female; Flecainide; Humans; Infusions, Intravenous; Lidocaine; Male; Middle Aged

2003
Use of bepridil in combination with Ic antiarrhythmic agent in converting persistent atrial fibrillation to sinus rhythm.
    Circulation journal : official journal of the Japanese Circulation Society, 2008, Volume: 72, Issue:5

    Topics: Adult; Aged; Anti-Arrhythmia Agents; Atrial Fibrillation; Atrial Natriuretic Factor; Bepridil; Drug Therapy, Combination; Electrocardiography; Female; Flecainide; Follow-Up Studies; Humans; Imidazoles; Lidocaine; Male; Middle Aged; Natriuretic Peptide, Brain; Sinoatrial Node; Treatment Outcome

2008

Other Studies

22 other study(ies) available for pilsicainide and flecainide

ArticleYear
Predicting hERG activities of compounds from their 3D structures: development and evaluation of a global descriptors based QSAR model.
    European journal of medicinal chemistry, 2011, Volume: 46, Issue:2

    Topics: Computer Simulation; Ether-A-Go-Go Potassium Channels; Humans; Molecular Structure; Organic Chemicals; Quantitative Structure-Activity Relationship

2011
Blockade of 2,4-dinitrophenol induced ATP sensitive potassium current in guinea pig ventricular myocytes by class I antiarrhythmic drugs.
    Cardiovascular research, 1992, Volume: 26, Issue:11

    Topics: 2,4-Dinitrophenol; Action Potentials; Adenosine Triphosphate; Animals; Anti-Arrhythmia Agents; Dinitrophenols; Disopyramide; Flecainide; Glyburide; Guinea Pigs; Heart Ventricles; Imidazoles; Lidocaine; Mexiletine; Myocardium; Piperidines; Potassium; Procainamide; Pyridines

1992
[Pharmacokinetics and pharmacodynamics of class I antiarrhythmic agents after a single oral administration].
    Japanese circulation journal, 1992, Volume: 56 Suppl 5

    Topics: Administration, Oral; Anti-Arrhythmia Agents; Aprindine; Flecainide; Humans; Imidazoles; Lidocaine; Mexiletine; Piperidines; Propafenone

1992
[Estimation of depressant effects of class I antiarrhythmic drugs on intraventricular conduction--rate-dependent effects on QRS duration].
    Japanese circulation journal, 1992, Volume: 56 Suppl 5

    Topics: Anti-Arrhythmia Agents; Aprindine; Depression, Chemical; Disopyramide; Electrocardiography; Flecainide; Heart Conduction System; Heart Rate; Humans; Lidocaine; Mexiletine; Sodium Channels; Ventricular Function

1992
Mechanisms of the anticholinergic effect of SUN 1165 in comparison with flecainide, disopyramide and quinidine in single atrial myocytes isolated from guinea-pig.
    British journal of pharmacology, 1991, Volume: 104, Issue:4

    Topics: Acetylcholine; Animals; Anti-Arrhythmia Agents; Disopyramide; Flecainide; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; Guinea Pigs; Heart; In Vitro Techniques; Lidocaine; Male; Myocardium; Parasympatholytics; Potassium Channels; Quinidine; Receptors, Cholinergic

1991
Effects of pilsicainide on systemic hemodynamics and cardiac function of anesthetized dogs.
    Cardioscience, 1993, Volume: 4, Issue:4

    Topics: Anesthesia, Intravenous; Animals; Anti-Arrhythmia Agents; Depression, Chemical; Dogs; Female; Flecainide; Heart; Hemodynamics; Lidocaine; Male; Myocardial Contraction; Propafenone

1993
Improvement of ischemia/reperfusion-induced contractile dysfunction of perfused hearts by class Ic antiarrhythmic agents.
    The Journal of pharmacology and experimental therapeutics, 1993, Volume: 266, Issue:3

    Topics: Adenosine Triphosphate; Animals; Anti-Arrhythmia Agents; Creatine Kinase; Flecainide; Heart; Lidocaine; Male; Metals; Myocardial Contraction; Myocardial Ischemia; Myocardial Reperfusion Injury; Myocardium; Perfusion; Rats; Rats, Wistar; Ventricular Function, Left

1993
Effects of pilsicainide on the atrial fibrillation threshold in guinea pig atria. A comparative study with disopyramide, lidocaine and flecainide.
    Japanese heart journal, 1993, Volume: 34, Issue:3

    Topics: Animals; Anti-Arrhythmia Agents; Atrial Fibrillation; Disopyramide; Electrophysiology; Female; Flecainide; Guinea Pigs; Heart; Heart Atria; In Vitro Techniques; Lidocaine; Male

1993
Antiarrhythmic agents act differently on the activation phase of the ACh-response in guinea-pig atrial myocytes.
    British journal of pharmacology, 1993, Volume: 108, Issue:1

    Topics: Acetylcholine; Animals; Anti-Arrhythmia Agents; Disopyramide; Electric Conductivity; Flecainide; Guinea Pigs; Lidocaine; Male; Myocardium; Potassium; Potassium Channels; Propafenone

1993
Mechanisms of negative inotropic effects of class Ic antiarrhythmic agents: comparative study of the effects of flecainide and pilsicainide on intracellular calcium handling in dog ventricular myocardium.
    Journal of cardiovascular pharmacology, 1996, Volume: 27, Issue:1

    Topics: Animals; Anti-Arrhythmia Agents; Calcium; Calcium Channels; Depression, Chemical; Dogs; Dose-Response Relationship, Drug; Flecainide; Heart Ventricles; Lidocaine; Myocardial Contraction; Myocardium; Sarcolemma

1996
Class IC antiarrhythmic drugs, flecainide and pilsicainide, produce ST segment elevation simulating inferior myocardial ischemia.
    Journal of cardiovascular electrophysiology, 1998, Volume: 9, Issue:8

    Topics: Anti-Arrhythmia Agents; Diagnosis, Differential; Drug Therapy, Combination; Electrocardiography; Flecainide; Heart; Humans; Lidocaine; Male; Middle Aged; Myocardial Ischemia; Tachycardia, Ventricular

1998
ST segment elevation in the right precordial leads induced with class IC antiarrhythmic drugs: insight into the mechanism of Brugada syndrome.
    Journal of cardiovascular electrophysiology, 1999, Volume: 10, Issue:2

    Topics: Anti-Arrhythmia Agents; Atrial Fibrillation; Electrocardiography; Flecainide; Follow-Up Studies; Heart Rate; Humans; Lidocaine; Male; Middle Aged; Procainamide; Recurrence; Tachycardia, Paroxysmal; Tachycardia, Ventricular; Wolff-Parkinson-White Syndrome

1999
ST segment elevation in the right precordial leads following administration of class Ic antiarrhythmic drugs.
    Heart (British Cardiac Society), 2001, Volume: 85, Issue:1

    Topics: Aged; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Atrial Fibrillation; Electrocardiography; Female; Flecainide; Humans; Lidocaine; Male; Middle Aged; Retrospective Studies

2001
Syncope in patients with atrial flutter during treatment with class Ic antiarrhythmic drugs.
    Journal of electrocardiology, 2001, Volume: 34, Issue:1

    Topics: Adult; Anti-Arrhythmia Agents; Atrial Flutter; Catheter Ablation; Electrocardiography; Electrophysiologic Techniques, Cardiac; Exercise; Flecainide; Humans; Lidocaine; Male; Middle Aged; Syncope; Tachycardia

2001
Atrial fibrillation threshold predicted long-term efficacy of pharmacological treatment of patients without structural heart disease.
    Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology, 2002, Volume: 4, Issue:4

    Topics: Aged; Anti-Arrhythmia Agents; Aprindine; Atrial Fibrillation; Disopyramide; Electrophysiologic Techniques, Cardiac; Female; Flecainide; Humans; Imidazoles; Lidocaine; Male; Middle Aged; Treatment Outcome

2002
Evaluation of the effect of bepridil on paroxysmal atrial fibrillation: relationship between efficacy and the f-f interval in surface ECG recordings.
    Circulation journal : official journal of the Japanese Circulation Society, 2003, Volume: 67, Issue:1

    Topics: Aged; Anti-Arrhythmia Agents; Atrial Fibrillation; Bepridil; Calcium Channel Blockers; Electrocardiography; Female; Flecainide; Humans; Lidocaine; Male; Middle Aged; Sodium Channel Blockers; Treatment Outcome

2003
Therapeutic monitoring of class I antiarrhythmic agents using high-resolution electrocardiography instead of blood samples.
    Circulation journal : official journal of the Japanese Circulation Society, 2003, Volume: 67, Issue:3

    Topics: Aged; Anti-Arrhythmia Agents; Drug Monitoring; Electrocardiography; Female; Flecainide; Humans; Lidocaine; Male; Middle Aged; Piperidines

2003
The effects of class Ic antiarrhythmics on tetrodotoxin-resistant Na+ currents in rat sensory neurons.
    Anesthesia and analgesia, 2004, Volume: 99, Issue:2

    Topics: Algorithms; Anesthetics, Local; Animals; Anti-Arrhythmia Agents; Drug Interactions; Drug Resistance; Flecainide; Ganglia, Spinal; Lidocaine; Male; Neurons, Afferent; Rats; Rats, Sprague-Dawley; Sodium Channel Blockers; Sodium Channels; Tetrodotoxin

2004
Differentiation of the electrophysiological effects on the atrial myocardium between the pure Na channel blocker, pilsicainide, and flecainide.
    Cardiovascular drugs and therapy, 2004, Volume: 18, Issue:4

    Topics: Adult; Anti-Arrhythmia Agents; Atrial Flutter; Electrocardiography; Electrophysiologic Techniques, Cardiac; Female; Flecainide; Heart Atria; Heart Conduction System; Heart Ventricles; Humans; Lidocaine; Male; Middle Aged; Myocardium; Prospective Studies; Refractory Period, Electrophysiological; Research Design; Sodium Channel Blockers; Tachycardia, Atrioventricular Nodal Reentry; Tachycardia, Ventricular; Treatment Outcome; Wolff-Parkinson-White Syndrome

2004
Clinical and electrophysiological characteristics of patients having atrial flutter with 1:1 atrioventricular conduction.
    Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology, 2008, Volume: 10, Issue:3

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Amiodarone; Anti-Arrhythmia Agents; Atrial Flutter; Case-Control Studies; Catheter Ablation; Electrocardiography; Electrophysiologic Techniques, Cardiac; Female; Flecainide; Heart Atria; Heart Conduction System; Heart Ventricles; Humans; Imidazoles; Lidocaine; Male; Middle Aged; Retrospective Studies; Risk Factors

2008
Molecular determinants of state-dependent block of voltage-gated sodium channels by pilsicainide.
    British journal of pharmacology, 2010, Volume: 160, Issue:6

    Topics: Brain; Cell Line; Flecainide; Heart; Humans; Lidocaine; Mexiletine; Muscle Proteins; Muscle, Skeletal; NAV1.1 Voltage-Gated Sodium Channel; NAV1.4 Voltage-Gated Sodium Channel; NAV1.5 Voltage-Gated Sodium Channel; Nerve Tissue Proteins; Patch-Clamp Techniques; Sodium Channel Blockers; Sodium Channels

2010
Significance of electrocardiogram recording in high intercostal spaces in patients with early repolarization syndrome.
    European heart journal, 2016, Feb-14, Volume: 37, Issue:7

    Topics: Adult; Anti-Arrhythmia Agents; Brugada Syndrome; Electrocardiography; Electrophysiologic Techniques, Cardiac; Female; Flecainide; Humans; Lidocaine; Male; Prognosis; Recurrence; Risk Assessment; Ventricular Fibrillation

2016