Page last updated: 2024-08-17

pilocarpine and valproic acid

pilocarpine has been researched along with valproic acid in 41 studies

Research

Studies (41)

Timeframe	Studies, this research(%)	All Research%
pre-1990	1 (2.44)	18.7374
1990's	2 (4.88)	18.2507
2000's	10 (24.39)	29.6817
2010's	22 (53.66)	24.3611
2020's	6 (14.63)	2.80

Authors

Authors	Studies
Andrews, PR; Craik, DJ; Martin, JL	1
Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL	1
Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM	1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A	1
Choi, SS; Contrera, JF; Hastings, KL; Kruhlak, NL; Sancilio, LF; Weaver, JL; Willard, JM	1
Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ	1
Ekins, S; Williams, AJ; Xu, JJ	1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K	1
George, B; Kulkarni, SK	1
DeMet, EM; Sokolski, KN	1
Bialer, M; Ebinger, G; Khan, GM; Lindekens, H; Michotte, Y; Smolders, I	1
Grimee, R; Klitgaard, H; Margineanu, DG; Matagne, A; Vanneste-Goemaere, J	1
Bogo, MR; Bonan, CD; Bruno, AN; Cognato, Gde P; da Silva, RS; Sarkis, JJ	1
Choi, HC; Choi, SY; Kang, TC; Kim, DS; Kim, JE; Kim, YI; Kwak, SE; Kwon, OS; Song, HK	1
Khan, FA; Lian, XY; Stringer, JL	1
Khongsombat, O; Patarapanich, C; Tantisira, B; Tantisira, MH; Watanabe, H	1
El Elshamy, KA; Elwakkad, AS; Sibaii, H	1
Choi, HC; Choi, SY; Jo, SM; Kang, TC; Kim, DS; Kim, JE; Kim, YI; Song, HK	1
Chen, L; Feng, Q; Ji, YH; Wang, Y; Weng, CC; Zhang, XY; Zhao, R; Zhu, HY	1
Ezz, HS; Khadrawy, YA; Noor, NA	1
Baraka, AM; El Ghotni, S; Hassab El Nabi, W	1
Aboul Ezz, HS; Faraag, AR; Khadrawy, YA; Noor, NA	1
Bialer, M; Dudek, FE; Hen, N; Kaufmann, D; Nelson, C; Pouliot, W; Ricks, K; Roach, B; Shekh-Ahmad, T; Yagen, B	1
Choi, HC; Kang, TC; Kim, JE; Kim, YI; Lee, DS; Ryu, HJ; Song, HK	1
Jiang, W; Wang, Y; Wei, D; Wu, C; Wu, SX; Yang, F	1
Akula, KK; Boison, D; Coffman, SQ; Lusardi, TA; Masino, SA; Ruskin, DN	1
Löscher, W; Töllner, K; Twele, F	1
Blanco, MM; Cinini, SM; Lima, TZ; Mello, LE; Pontes, JC; Queiroz, CM	1
Baldwin, R; Lumley, L; Niquet, J; Norman, K; Suchomelova, L; Wasterlain, CG	2
Andres-Mach, M; Dudra-Jastrzębska, M; Haratym, J; Haratym-Maj, A; Maj, M; Rola, R; Zagaja, M; Łuszczki, JJ	1
Hu, Y; Jiang, L; Liu, BK; Ran, X; Song, PP; Xiang, J	1
Jand, A; Mousavi-Hasanzadeh, M; Palizvan, MR; Rezaeian-Varmaziar, H; Shafaat, O	1
Bigonah, R; Ganjkhani, M; Nourozi, S; Rostami, A; Shokri, S	1
Baldwin, R; Estrada, IBF; Furtado, MA; Lumley, L; Naylor, D; Niquet, J; Rossetti, F; Schultz, M; Suchomelova, L; Wasterlain, CG	1
Baldwin, R; de Araujo Furtado, M; Franco-Estrada, I; Lumley, L; Naylor, D; Niquet, J; Rossetti, F; Schultz, M; Suchomelova, L; Wasterlain, CG	1
Al-Rafiah, AR; Mehdar, KM	1
Abdel-Daim, MM; Almeer, R; Kamel, M; Najda, A; Nurzyńska-Wierdak, R; Singh, M; Singh, S; Singh, TG	1
Bum, EN; Kouemou Emegam, N; Neteydji, S; Pale, S; Taiwe, GS	1
Singh, S; Singh, TG	1
Chen, H; Cheng, L; Hu, Y; Yi, Y; Zhang, X	1

Reviews

3 review(s) available for pilocarpine and valproic acid

Article	Year
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug discovery today, 2016, Volume: 21, Issue:4 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk	2016
Rational polytherapy in the treatment of cholinergic seizures. Neurobiology of disease, 2020, Volume: 133 Topics: Animals; Anticonvulsants; Cholinesterase Inhibitors; Drug Therapy, Combination; Ketamine; Male; Midazolam; Muscarinic Agonists; Nerve Agents; Pilocarpine; Rats; Rats, Sprague-Dawley; Soman; Status Epilepticus; Valproic Acid	2020
Early polytherapy for benzodiazepine-refractory status epilepticus. Epilepsy & behavior : E&B, 2019, Volume: 101, Issue:Pt B Topics: Animals; Anticonvulsants; Benzodiazepines; Drug Administration Schedule; Drug Resistant Epilepsy; Drug Therapy, Combination; Humans; Midazolam; Pilocarpine; Receptors, GABA-A; Receptors, N-Methyl-D-Aspartate; Seizures; Status Epilepticus; Valproic Acid	2019

Other Studies

38 other study(ies) available for pilocarpine and valproic acid

Article	Year
Functional group contributions to drug-receptor interactions. Journal of medicinal chemistry, 1984, Volume: 27, Issue:12 Topics: Animals; Calorimetry; Kinetics; Models, Biological; Protein Binding; Receptors, Cell Surface; Receptors, Drug; Structure-Activity Relationship	1984
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling. Current drug discovery technologies, 2004, Volume: 1, Issue:4 Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration	2004
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1. Journal of medicinal chemistry, 2008, Oct-09, Volume: 51, Issue:19 Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship	2008
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Chemical research in toxicology, 2010, Volume: 23, Issue:1 Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship	2010
Development of a phospholipidosis database and predictive quantitative structure-activity relationship (QSAR) models. Toxicology mechanisms and methods, 2008, Volume: 18, Issue:2-3 Topics:	2008
Developing structure-activity relationships for the prediction of hepatotoxicity. Chemical research in toxicology, 2010, Jul-19, Volume: 23, Issue:7 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes	2010
A predictive ligand-based Bayesian model for human drug-induced liver injury. Drug metabolism and disposition: the biological fate of chemicals, 2010, Volume: 38, Issue:12 Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands	2010
Protective effects of GABAergic drugs and other anticonvulsants in lithium-pilocarpine-induced status epilepticus. Methods and findings in experimental and clinical pharmacology, 1996, Volume: 18, Issue:5 Topics: Animals; Anticonvulsants; Baclofen; Clonazepam; Diazepam; Dizocilpine Maleate; Ethanol; GABA Agents; gamma-Aminobutyric Acid; Lithium Chloride; Male; Neuroprotective Agents; Pentobarbital; Phenobarbital; Phenytoin; Pilocarpine; Rats; Rats, Wistar; Status Epilepticus; Valproic Acid	1996
Sodium valproate increases pupillary responsiveness to a cholinergic agonist in responders with mania. Biological psychiatry, 1999, Aug-01, Volume: 46, Issue:3 Topics: Adult; Bipolar Disorder; Cholinergic Agonists; Humans; Male; Middle Aged; Muscarinic Agonists; Pilocarpine; Receptors, Muscarinic; Reflex, Pupillary; Treatment Outcome; Valproic Acid	1999
In vivo study of the effect of valpromide and valnoctamide in the pilocarpine rat model of focal epilepsy. Pharmaceutical research, 2000, Volume: 17, Issue:11 Topics: Amides; Animals; Anti-Anxiety Agents; Anticonvulsants; Epilepsies, Partial; gamma-Aminobutyric Acid; Glutamic Acid; Hippocampus; Male; Microdialysis; Muscarinic Agonists; Pilocarpine; Rats; Rats, Wistar; Valproic Acid	2000
Electrophysiological, neurochemical and regional effects of levetiracetam in the rat pilocarpine model of temporal lobe epilepsy. Seizure, 2003, Volume: 12, Issue:2 Topics: Animals; Anticonvulsants; Aspartic Acid; Clonazepam; Electroencephalography; Epilepsy, Temporal Lobe; gamma-Aminobutyric Acid; Hippocampus; Injections, Intraperitoneal; Levetiracetam; Male; Microinjections; Phenobarbital; Pilocarpine; Piracetam; Rats; Rats, Sprague-Dawley; Valproic Acid	2003
Antiepileptic drugs prevent changes induced by pilocarpine model of epilepsy in brain ecto-nucleotidases. Neurochemical research, 2007, Volume: 32, Issue:6 Topics: Adenosine Diphosphate; Adenosine Monophosphate; Adenosine Triphosphatases; Adenosine Triphosphate; Animals; Anticonvulsants; Brain; Carbamazepine; Cerebral Cortex; Epilepsy; Hippocampus; Male; Muscarinic Agonists; Phenytoin; Pilocarpine; Rats; Rats, Wistar; Reverse Transcriptase Polymerase Chain Reaction; Synaptosomes; Valproic Acid	2007
Anti-glutamatergic effect of riluzole: comparison with valproic acid. Neuroscience, 2007, Jun-15, Volume: 147, Issue:1 Topics: Animals; Anticonvulsants; Dentate Gyrus; Disease Models, Animal; Epilepsy, Absence; Excitatory Postsynaptic Potentials; Limbic System; Male; Pilocarpine; Rats; Rats, Sprague-Dawley; Riluzole; Seizures; Sodium Oxybate; Status Epilepticus; Valproic Acid; Vesicular Glutamate Transport Protein 1	2007
Fructose-1,6-bisphosphate has anticonvulsant activity in models of acute seizures in adult rats. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2007, Oct-31, Volume: 27, Issue:44 Topics: Acute Disease; Allylamine; Analysis of Variance; Animals; Anticonvulsants; Behavior, Animal; Deoxyglucose; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Combinations; Fructosediphosphates; Kainic Acid; Male; Meperidine; Models, Chemical; Pilocarpine; Rats; Rats, Sprague-Dawley; Seizures; Valproic Acid	2007
Acute effects of N-(2-propylpentanoyl)urea on hippocampal amino acid neurotransmitters in pilocarpine-induced seizure in rats. Epilepsy research, 2008, Volume: 79, Issue:2-3 Topics: Amino Acids; Animals; Anticonvulsants; Hippocampus; Male; Microdialysis; Muscarinic Agonists; Neurotransmitter Agents; Pilocarpine; Rats; Rats, Wistar; Seizures; Urea; Valproic Acid	2008
Fish liver oil and propolis as protective natural products against the effect of the anti-epileptic drug valproate on immunological markers of bone formation in rats. Epilepsy research, 2008, Volume: 80, Issue:1 Topics: Alkaline Phosphatase; Animals; Anticonvulsants; Atropine; Biomarkers; Bone Resorption; Disease Models, Animal; Epilepsy; Fish Oils; Male; Osteocalcin; Osteogenesis; Osteoporosis; Osteoprotegerin; Pilocarpine; Propolis; RANK Ligand; Rats; Rats, Sprague-Dawley; Time Factors; Tumor Necrosis Factor-alpha; Valproic Acid	2008
Levetiracetam inhibits interleukin-1 beta inflammatory responses in the hippocampus and piriform cortex of epileptic rats. Neuroscience letters, 2010, Mar-03, Volume: 471, Issue:2 Topics: Animals; Anticonvulsants; Astrocytes; Chronic Disease; Epilepsy; Gliosis; Hippocampus; Interleukin-1beta; Levetiracetam; Male; Microglia; Olfactory Pathways; Pilocarpine; Piracetam; Rats; Rats, Sprague-Dawley; Receptors, Interleukin-1 Type I; Valproic Acid	2010
Anticonvulsant activity of BmK AS, a sodium channel site 4-specific modulator. Epilepsy & behavior : E&B, 2011, Volume: 20, Issue:2 Topics: Analysis of Variance; Animals; Anticonvulsants; Behavior, Animal; Cells, Cultured; Convulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Electroencephalography; Embryo, Mammalian; Exploratory Behavior; Male; Membrane Potentials; Motor Activity; Neurons; Patch-Clamp Techniques; Pentylenetetrazole; Peptides; Pilocarpine; Rats; Rats, Sprague-Dawley; Reaction Time; Scorpion Venoms; Seizures; Sodium Channel Blockers; Sodium Channels; Tetrodotoxin; Valproic Acid	2011
The neuroprotective effect of curcumin and Nigella sativa oil against oxidative stress in the pilocarpine model of epilepsy: a comparison with valproate. Neurochemical research, 2011, Volume: 36, Issue:11 Topics: Acetylcholinesterase; Animals; Curcumin; Epilepsy; Glutathione; Hippocampus; Lipid Peroxidation; Nigella sativa; Oxidative Stress; Pilocarpine; Plant Oils; Rats; Sodium-Potassium-Exchanging ATPase; Valproic Acid	2011
Investigating the role of zinc in a rat model of epilepsy. CNS neuroscience & therapeutics, 2012, Volume: 18, Issue:4 Topics: Animals; Disease Models, Animal; Drug Therapy, Combination; Epilepsy; Hippocampus; Male; Pilocarpine; Rats; Rats, Wistar; Valproic Acid; Zinc	2012
Evaluation of the antiepileptic effect of curcumin and Nigella sativa oil in the pilocarpine model of epilepsy in comparison with valproate. Epilepsy & behavior : E&B, 2012, Volume: 24, Issue:2 Topics: Amino Acids; Animals; Anticonvulsants; Behavior, Animal; Cerebral Cortex; Chromatography, High Pressure Liquid; Convulsants; Curcumin; Dansyl Compounds; Epilepsy; Hippocampus; Male; Neurotransmitter Agents; Nigella sativa; Pilocarpine; Plant Oils; Rats; Rats, Wistar; Valproic Acid	2012
A comparative electrographic analysis of the effect of sec-butyl-propylacetamide on pharmacoresistant status epilepticus. Neuroscience, 2013, Feb-12, Volume: 231 Topics: Amides; Animals; Anticonvulsants; Cerebral Cortex; Diazepam; Dose-Response Relationship, Drug; Electroencephalography; Male; Pentobarbital; Pilocarpine; Rats; Rats, Sprague-Dawley; Status Epilepticus; Valproic Acid	2013
The effect of levetiracetam on status epilepticus-induced neuronal death in the rat hippocampus. Seizure, 2013, Volume: 22, Issue:5 Topics: Animals; Behavior, Animal; Cell Death; Diazepam; Disease Models, Animal; Drug Therapy, Combination; Fluoresceins; Hippocampus; Levetiracetam; Neurons; Pilocarpine; Piracetam; Rats; Rats, Sprague-Dawley; Status Epilepticus; Valproic Acid	2013
Degeneration and regeneration of GABAergic interneurons in the dentate gyrus of adult mice in experimental models of epilepsy. CNS neuroscience & therapeutics, 2015, Volume: 21, Issue:1 Topics: Animals; Chronic Disease; Dentate Gyrus; Epilepsy; GABAergic Neurons; Glutamate Decarboxylase; Green Fluorescent Proteins; Interneurons; Kindling, Neurologic; Lithium Compounds; Male; Mice, Transgenic; Nerve Degeneration; Nerve Regeneration; Neural Stem Cells; Neurogenesis; Pentylenetetrazole; Pilocarpine; Status Epilepticus; Valproic Acid	2015
Ketogenic diet prevents epileptogenesis and disease progression in adult mice and rats. Neuropharmacology, 2015, Volume: 99 Topics: Adenosine; Animals; Anticonvulsants; Diet, Ketogenic; Disease Models, Animal; Disease Progression; DNA Methylation; Hippocampus; Kindling, Neurologic; Male; Mice; Pentylenetetrazole; Pilocarpine; Random Allocation; Rats, Wistar; Seizures; Status Epilepticus; Valproic Acid	2015
Evaluation of the pentylenetetrazole seizure threshold test in epileptic mice as surrogate model for drug testing against pharmacoresistant seizures. Epilepsy & behavior : E&B, 2016, Volume: 57, Issue:Pt A Topics: Animals; Anticonvulsants; Diazepam; Disease Models, Animal; Drug Resistance; Epilepsy; GABA Antagonists; Levetiracetam; Male; Mice; Pentylenetetrazole; Phenobarbital; Pilocarpine; Piracetam; Rats; Seizures; Status Epilepticus; Valproic Acid	2016
Seizures triggered by pentylenetetrazol in marmosets made chronically epileptic with pilocarpine show greater refractoriness to treatment. Epilepsy research, 2016, Volume: 126 Topics: Animals; Anticonvulsants; Brain; Callithrix; Carbamazepine; Chronic Disease; Disease Models, Animal; Electrocorticography; Epilepsy; Female; Immunohistochemistry; Male; Neuropeptide Y; Pentylenetetrazole; Phenobarbital; Pilocarpine; Proto-Oncogene Proteins c-fos; Seizures; Valproic Acid	2016
Midazolam-ketamine dual therapy stops cholinergic status epilepticus and reduces Morris water maze deficits. Epilepsia, 2016, Volume: 57, Issue:9 Topics: Animals; Anticonvulsants; Brain; Cholinergic Agents; Disease Models, Animal; Drug Synergism; Drug Therapy, Combination; Ketamine; Learning Disabilities; Lithium Chloride; Male; Maze Learning; Midazolam; N-Methylscopolamine; Pilocarpine; Rats; Rats, Sprague-Dawley; Status Epilepticus; Valproic Acid	2016
A Long-Term Treatment with Arachidonyl-2'-Chloroethylamide Combined with Valproate Increases Neurogenesis in a Mouse Pilocarpine Model of Epilepsy. International journal of molecular sciences, 2017, Apr-25, Volume: 18, Issue:5 Topics: Animals; Anticonvulsants; Arachidonic Acids; Astrocytes; Disease Models, Animal; Drug Therapy, Combination; Epilepsy; Immunohistochemistry; Male; Mice; Mice, Inbred C57BL; Microscopy, Confocal; Neurogenesis; Pilocarpine; Valproic Acid	2017
Simultaneous triple therapy for the treatment of status epilepticus. Neurobiology of disease, 2017, Volume: 104 Topics: Animals; Anticonvulsants; Brain Waves; Combined Modality Therapy; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Therapy, Combination; Electroencephalography; Male; Maze Learning; Midazolam; Neurons; Phenytoin; Pilocarpine; Rats; Rats, Sprague-Dawley; Status Epilepticus; Treatment Outcome; Valproic Acid	2017
Effects of gap junctions blockers on fast ripples and connexin in rat hippocampi after status epilepticus. Epilepsy research, 2018, Volume: 146 Topics: Animals; Anticonvulsants; Carbenoxolone; Connexins; Electrocorticography; Gap Junctions; Gene Expression; Hippocampus; Lithium Compounds; Male; Pilocarpine; Quinine; Random Allocation; Rats, Sprague-Dawley; Status Epilepticus; Valproic Acid	2018
The effect of co-administration of pentylenetetrazole with pilocarpine: New modified PTZ models of kindling and seizure. Pharmacology, biochemistry, and behavior, 2019, Volume: 182 Topics: Animals; Anticonvulsants; Convulsants; Disease Models, Animal; Drug Resistance; Epilepsy; Kindling, Neurologic; Male; Miotics; Pentylenetetrazole; Phenytoin; Pilocarpine; Rats; Rats, Wistar; Seizures; Valproic Acid	2019
Ameliorating impacts of ginseng on the apoptosis of spermatogenic cells and sperm quality in temporal lobe epilepsy rat model treated with valproate. Andrologia, 2019, Volume: 51, Issue:9 Topics: Animals; Anticonvulsants; Apoptosis; Disease Models, Animal; Epilepsy, Temporal Lobe; Humans; Infertility, Male; Injections, Intraperitoneal; Male; Panax; Pilocarpine; Plant Extracts; Rats; Seminiferous Epithelium; Sperm Motility; Spermatogenesis; Spermatozoa; Treatment Outcome; Valproic Acid	2019
Histopathological and Biochemical Assessment of Neuroprotective Effects of Sodium Valproate and Lutein on the Pilocarpine Albino Rat Model of Epilepsy. Behavioural neurology, 2021, Volume: 2021 Topics: Animals; Anticonvulsants; Disease Models, Animal; Epilepsy; Humans; Lutein; Neuroprotective Agents; Pilocarpine; Rats; Valproic Acid	2021
Anticonvulsive Effects of Chondroitin Sulfate on Pilocarpine and Pentylenetetrazole Induced Epileptogenesis in Mice. Molecules (Basel, Switzerland), 2021, Nov-09, Volume: 26, Issue:22 Topics: Animals; Anticonvulsants; Chondroitin Sulfates; Male; Mice; Molecular Docking Simulation; Neuroprotective Agents; Oxidative Stress; Pentylenetetrazole; Pilocarpine; Seizures; Status Epilepticus; Valproic Acid	2021
Anticonvulsant effects of Cymbopogon giganteus extracts with possible effects on fully kindled seizures and anxiety in experimental rodent model of mesio-temporal epilepsy induced by pilocarpine. Journal of ethnopharmacology, 2022, Mar-25, Volume: 286 Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Anxiety; Cymbopogon; Disease Models, Animal; Dose-Response Relationship, Drug; Epilepsy, Temporal Lobe; Kindling, Neurologic; Male; Maze Learning; Pilocarpine; Plant Extracts; Rats; Rats, Wistar; Valproic Acid	2022
Imatinib Attenuates Pentylenetetrazole Kindled and Pilocarpine Induced Recurrent Spontaneous Seizures in Mice. Neurochemical research, 2023, Volume: 48, Issue:2 Topics: Animals; Anticonvulsants; Disease Models, Animal; Epilepsy; Imatinib Mesylate; Mice; Pentylenetetrazole; Pilocarpine; Seizures; Status Epilepticus; Valproic Acid	2023
Dynamic effects of miR-20a-5p on hippocampal ripple energy after status epilepticus in rats. Experimental brain research, 2023, Volume: 241, Issue:8 Topics: Animals; Chloral Hydrate; Hippocampus; MicroRNAs; Pilocarpine; Rats; Seizures; Status Epilepticus; Valproic Acid	2023