pilocarpine has been researched along with topiramate in 20 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 11 (55.00) | 29.6817 |
| 2010's | 5 (25.00) | 24.3611 |
| 2020's | 4 (20.00) | 2.80 |
| Authors | Studies |
|---|---|
| Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL | 1 |
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Ekins, S; Williams, AJ; Xu, JJ | 1 |
| Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K | 1 |
| Cha, BH; Holmes, GL; Hu, Y; Liu, X; Silveira, DC | 1 |
| Augarten, A; Ben-Zeev, B; Blatt, I; Brand, N; Efrati, O; Topper, L; Watemberg, N; Yahav, Y | 1 |
| Ferrandon, A; Koning, E; Nehlig, A; Rigoulot, MA | 1 |
| Debska-Vielhaber, G; Elger, CE; Kudin, AP; Kunz, WS; Vielhaber, S | 1 |
| Chapman, PL; Dudek, FE; Ferraro, DJ; Grabenstatter, HL; Williams, PA | 1 |
| Baldwin, RA; Kubova, H; Sankar, R; Suchomelova, L; Thompson, KW; Wasterlain, CG | 1 |
| Ferrandon, A; François, J; Koning, E; Nehlig, A | 1 |
| Clinckers, R; Ebinger, G; Meurs, A; Michotte, Y; Smolders, I | 1 |
| Elger, CE; Frisch, C; Helmstaedter, C; Kudin, AP; Kunz, WS | 1 |
| André, V; Dubé, C; François, J; Leroy, C; Namer, IJ; Nehlig, A; Rigoulot, MA; Roch, C | 1 |
| Brzana, W; Czuczwar, M; Kiś, J; Nieoczym, D; Turski, WA; Wlaź, P; Zgrajka, W | 1 |
| Guglani, L; Kurland, G; Lower, D; Sitwat, B; Weiner, DJ | 1 |
| Georgieva, K; Ivanova, N; Nenchovska, Z; Peychev, L; Shishmanova-Doseva, M; Tchekalarova, J | 1 |
| Atanasova, M; Georgieva, K; Peychev, L; Shishmanova-Doseva, M; Tchekalarova, J; Uzunova, Y; Yoanidu, L | 1 |
| Atanasova, D; Atanasova, M; Ioanidu, L; Peychev, L; Shishmanova-Doseva, M; Tchekalarova, J; Uzunova, Y | 1 |
| Boison, D; D'Ambrosio, R; Eastman, C; Goodkin, HP; Klein, P; Löscher, W; Murugan, M; Purnell, B; Rotenberg, A; Rundfeldt, C | 1 |
1 review(s) available for pilocarpine and topiramate
| Article | Year |
|---|---|
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk | 2016 |
1 trial(s) available for pilocarpine and topiramate
| Article | Year |
|---|---|
Oligohydrosis and hyperthermia: pilot study of a novel topiramate adverse effect.
Topics: Adolescent; Adult; Anticonvulsants; Child; Child, Preschool; Epilepsy, Complex Partial; Female; Fever; Fructose; Humans; Hypohidrosis; Infant; Iontophoresis; Male; Muscarinic Agonists; Pilocarpine; Pilot Projects; Topiramate | 2003 |
18 other study(ies) available for pilocarpine and topiramate
| Article | Year |
|---|---|
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling.
Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration | 2004 |
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
A predictive ligand-based Bayesian model for human drug-induced liver injury.
Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands | 2010 |
Effect of topiramate following recurrent and prolonged seizures during early development.
Topics: Animals; Animals, Newborn; Anticonvulsants; Body Weight; Cell Death; Cognition; Convulsants; Disease Models, Animal; Epilepsy; Flurothyl; Fructose; Hippocampus; Lithium; Maze Learning; Mossy Fibers, Hippocampal; Muscarinic Agonists; Nerve Degeneration; Pilocarpine; Rats; Rats, Sprague-Dawley; Reaction Time; Recurrence; Research Design; Topiramate | 2002 |
Neuroprotective properties of topiramate in the lithium-pilocarpine model of epilepsy.
Topics: Animals; Blood Gas Analysis; Cell Death; Cerebral Cortex; Electroencephalography; Fructose; Hippocampus; Hydrogen-Ion Concentration; Lithium; Male; Neurons; Neuroprotective Agents; Pilocarpine; Rats; Rats, Sprague-Dawley; Status Epilepticus; Topiramate | 2004 |
The mechanism of neuroprotection by topiramate in an animal model of epilepsy.
Topics: Animals; Brain; Cell Survival; Cyclosporine; Disease Models, Animal; Dose-Response Relationship, Drug; Epilepsy; Fructose; Hippocampus; In Vitro Techniques; Ion Channels; Kindling, Neurologic; Male; Mitochondria; Mitochondrial Membrane Transport Proteins; Mitochondrial Permeability Transition Pore; Neuroprotective Agents; Oxidative Phosphorylation; Pilocarpine; Pyramidal Cells; Rats; Rats, Wistar; Status Epilepticus; Topiramate | 2004 |
Use of chronic epilepsy models in antiepileptic drug discovery: the effect of topiramate on spontaneous motor seizures in rats with kainate-induced epilepsy.
Topics: Animals; Anticonvulsants; Chronic Disease; Cross-Over Studies; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Epilepsy; Fructose; Injections, Intraperitoneal; Kainic Acid; Pilocarpine; Rats; Rats, Sprague-Dawley; Research Design; Sodium Chloride; Status Epilepticus; Topiramate | 2005 |
Treatment of experimental status epilepticus in immature rats: dissociation between anticonvulsant and antiepileptogenic effects.
Topics: Animals; Anticonvulsants; Atropine; Diazepam; Dose-Response Relationship, Drug; Electroencephalography; Fructose; Pilocarpine; Rats; Rats, Wistar; Status Epilepticus; Topiramate | 2006 |
The combination of topiramate and diazepam is partially neuroprotective in the hippocampus but not antiepileptogenic in the lithium-pilocarpine model of temporal lobe epilepsy.
Topics: Animals; Anticonvulsants; Diazepam; Disease Models, Animal; Drug Therapy, Combination; Electroencephalography; Epilepsy, Temporal Lobe; Fructose; Hippocampus; Lithium; Magnetic Resonance Imaging; Male; Pilocarpine; Rats; Rats, Sprague-Dawley; Status Epilepticus; Topiramate | 2006 |
Substantia nigra is an anticonvulsant site of action of topiramate in the focal pilocarpine model of limbic seizures.
Topics: Animals; Anticonvulsants; Area Under Curve; Behavior, Animal; Disease Models, Animal; Dose-Response Relationship, Drug; Epilepsies, Partial; Fructose; Functional Laterality; gamma-Aminobutyric Acid; Glutamates; Hippocampus; Male; Microdialysis; Microinjections; Pilocarpine; Rats; Rats, Wistar; Seizures; Substantia Nigra; Synaptic Transmission; Topiramate | 2006 |
Amelioration of water maze performance deficits by topiramate applied during pilocarpine-induced status epilepticus is negatively dose-dependent.
Topics: Animals; Anticonvulsants; Diazepam; Disease Models, Animal; Dose-Response Relationship, Drug; Fructose; Hippocampus; Male; Maze Learning; Memory; Neurons; Neuroprotective Agents; Pilocarpine; Rats; Rats, Wistar; Status Epilepticus; Swimming; Topiramate; Video Recording; Water | 2007 |
Pathogenesis and pharmacology of epilepsy in the lithium-pilocarpine model.
Topics: Animals; Animals, Newborn; Anticonvulsants; Autoradiography; Cell Count; Cerebral Cortex; Deoxyglucose; Disease Models, Animal; Electroencephalography; Electroshock; Entorhinal Cortex; Epilepsy, Temporal Lobe; Fructose; Glucose; Hippocampus; Kindling, Neurologic; Lithium Chloride; Magnetic Resonance Imaging; Olfactory Pathways; Pilocarpine; Rats; Rats, Sprague-Dawley; Status Epilepticus; Topiramate; Vigabatrin | 2007 |
Evidences for pharmacokinetic interaction of riluzole and topiramate with pilocarpine in pilocarpine-induced seizures in rats.
Topics: Animals; Anticonvulsants; Brain; Chromatography, High Pressure Liquid; Convulsants; Drug Interactions; Fructose; Male; Pilocarpine; Rats; Rats, Wistar; Riluzole; Seizures; Status Epilepticus; Topiramate | 2010 |
Elevated sweat chloride concentration in children without cystic fibrosis who are receiving topiramate therapy.
Topics: Adolescent; Analgesics; Anticonvulsants; Bronchi; Cells, Cultured; Child; Chlorides; Cystic Fibrosis; Female; Fructose; Humans; Iontophoresis; Male; Migraine Disorders; Pilocarpine; Sweat; Topiramate; Treatment Outcome | 2012 |
The Effect of Chronic Treatment with Lacosamide and Topiramate on Cognitive Functions and Impaired Emotional Responses in a Pilocarpine-induced Post-status Epilepticus Rat Model.
Topics: Animals; Anticonvulsants; Cognition; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Therapy, Combination; Emotional Regulation; Follow-Up Studies; Lacosamide; Male; Pilocarpine; Rats; Rats, Wistar; Status Epilepticus; Time Factors; Topiramate | 2020 |
Anticonvulsant Effects of Topiramate and Lacosamide on Pilocarpine-Induced Status Epilepticus in Rats: A Role of Reactive Oxygen Species and Inflammation.
Topics: Animals; Anticonvulsants; Biomarkers; Hippocampus; Inflammation; Interleukin-1beta; Lacosamide; Male; Motor Activity; Oxidative Stress; Pilocarpine; Rats, Wistar; Reactive Oxygen Species; Seizures; Status Epilepticus; Topiramate; Tumor Necrosis Factor-alpha | 2021 |
The anticonvulsant effect of chronic treatment with topiramate after pilocarpine-induced status epilepticus is accompanied by a suppression of comorbid behavioral impairments and robust neuroprotection in limbic regions in rats.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Epilepsy, Temporal Lobe; Hippocampus; Inflammation; Neuroprotection; Pilocarpine; Rats; Rats, Wistar; Seizures; Status Epilepticus; Topiramate | 2022 |
Preclinical pharmacokinetics and tolerability of a novel meglumine-based parenteral solution of topiramate and topiramate combinations for treatment of status epilepticus.
Topics: Animals; Anticonvulsants; Fructose; Levetiracetam; Pilocarpine; Rats; Status Epilepticus; Topiramate | 2023 |