Page last updated: 2024-08-17

pilocarpine and pilocarpic acid

pilocarpine has been researched along with pilocarpic acid in 25 studies

Research

Studies (25)

TimeframeStudies, this research(%)All Research%
pre-19906 (24.00)18.7374
1990's8 (32.00)18.2507
2000's7 (28.00)29.6817
2010's4 (16.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Dunn, DL; Fan, TY; Sternitzke, KD1
Auriola, S; Järvinen, T; Peura, P; Suhonen, P; Urtti, A; Vepsäläinen, J1
Järvinen, T; Naumanen, H; Peura, P; Suhonen, P; Urtti, A1
Goldhoorn, PB; Kuks, PF; Weekers, LE1
Costa-Segarra, J; Gomez-Gomar, A; Gonzalez-Aubert, M1
Durif, C; Kister, G; Puech, A; Ribes, M1
Bundgaard, H; Falch, E; Larsen, C; Mikkelson, TJ1
Ellis, PP; Gal, J; Rendi, MA1
Beyerman, HC; Maat, L; Noordam, A1
Kennedy, JM; McNamara, PE1
Kuwano, M; Matsuura, K; Takashina, H1
Aström, O; Persson, K1
Bohle, JF; Jonkman, JH; Oosterhuis, B; Tinke, AP; van de Merbel, NC1
Bayne, WF; Birk, KL; Cairns, AM; Demetriades, JL; Dru, JD; Hsieh, JY; Matuszewski, BK; Musson, DG; Rogers, JD; Woolf, EJ1
Arizzi, MN; Correa, M; Ishiwari, K; Salamone, JD; Wisniecki, A1
Becker, AJ; Blümcke, I; Chen, J; Elger, CE; Normann, S; Schramm, J; Sochivko, D; Wiestler, OD; Zien, A1
Brooks-Kayal, AR; Coulter, DA; Hsu, FC; Raol, YH; Zhang, G1
Fahnestock, M; McIntyre, DC; Racine, RJ; Xu, B1
Bonan, CD; Bruno, AN; de Paula Cognato, G; Sarkis, JJ; Vuaden, FC1
Endo, T; Fukami, T; Hara, Y; Hasunuma, T; Momose, Y; Nakajima, M; Yokoi, T1
Argüelles, D; Carmona, JU; Deulofeu, R; Martínez-Puig, D; Prades, M1
Fukami, T; Hioki, T; Nakajima, M; Yokoi, T1
Olson, JB; Shirey, TB; Thacker, RW1
Bronson, E; Cox, SK; Kilburn, JJ; Kottyan, J; Wack, AN1
Branstetter, D; Dougall, WC; Giner, G; Huang, LY; Lindeman, GJ; Lok, SW; Mann, GB; Nolan, E; Pal, B; Rohrbach, K; Smyth, GK; Soriano, R; Vaillant, F; Visvader, JE; Whitehead, L1

Trials

2 trial(s) available for pilocarpine and pilocarpic acid

ArticleYear
Determination of pilocarpic acid in human plasma by capillary gas chromatography with mass-selective detection.
    Journal of chromatography. B, Biomedical sciences and applications, 1998, Nov-20, Volume: 719, Issue:1-2

    Topics: Gas Chromatography-Mass Spectrometry; Humans; Hydrolysis; Pilocarpine; Reproducibility of Results; Sensitivity and Specificity

1998
Effect of the administration of an oral hyaluronan formulation on clinical and biochemical parameters in young horses with osteochondrosis.
    Veterinary and comparative orthopaedics and traumatology : V.C.O.T, 2009, Volume: 22, Issue:6

    Topics: Animals; Dinoprostone; Double-Blind Method; Horse Diseases; Horses; Hyaluronic Acid; Osteochondrosis; Pilocarpine; Synovial Fluid

2009

Other Studies

23 other study(ies) available for pilocarpine and pilocarpic acid

ArticleYear
High-performance liquid chromatographic determination of pilocarpine hydrochloride and its degradation products using a beta-cyclodextrin column.
    Journal of chromatography, 1992, Jan-10, Volume: 589, Issue:1-2

    Topics: beta-Cyclodextrins; Chromatography, High Pressure Liquid; Cyclodextrins; Pilocarpine

1992
Synthesis and identification of pilocarpic acid diesters, prodrugs of pilocarpine.
    Journal of pharmaceutical and biomedical analysis, 1991, Volume: 9, Issue:6

    Topics: Chromatography, Liquid; Esters; Magnetic Resonance Spectroscopy; Mass Spectrometry; Pilocarpine; Prodrugs

1991
Determination of physicochemical properties, stability in aqueous solutions and serum hydrolysis of pilocarpic acid diesters.
    Journal of pharmaceutical and biomedical analysis, 1991, Volume: 9, Issue:9

    Topics: Chromatography, High Pressure Liquid; Esters; Humans; Hydrolysis; Kinetics; Pilocarpine; Structure-Activity Relationship

1991
Decomposition of pilocarpine eye drops assessed by a highly efficient high pressure liquid chromatographic method.
    Pharmaceutisch weekblad. Scientific edition, 1990, Oct-19, Volume: 12, Issue:5

    Topics: Chromatography, High Pressure Liquid; Drug Stability; Indicators and Reagents; Ophthalmic Solutions; Pilocarpine

1990
HPLC method for the simultaneous determination of pilocarpine, isopilocarpine, pilocarpic acid and isopilocarpic acid.
    Journal of pharmaceutical and biomedical analysis, 1989, Volume: 7, Issue:12

    Topics: Chromatography, High Pressure Liquid; Indicators and Reagents; Pilocarpine; Solutions; Spectrophotometry, Ultraviolet; Tetraethylammonium Compounds

1989
[Rapid semiquantitative evaluation by thin-layer chromatography of pilo- and isopilocarpic acids in eyedrops with a pilocarpine base].
    Pharmaceutica acta Helvetiae, 1986, Volume: 61, Issue:5-6

    Topics: Chromatography, Thin Layer; Ophthalmic Solutions; Pilocarpine

1986
Pilocarpine prodrugs I. Synthesis, physicochemical properties and kinetics of lactonization of pilocarpic acid esters.
    Journal of pharmaceutical sciences, 1986, Volume: 75, Issue:1

    Topics: Chemical Phenomena; Chemistry, Physical; Chromatography, High Pressure Liquid; Drug Stability; Enzymes; Kinetics; Lactones; Pilocarpine; Solubility; Spectrophotometry, Ultraviolet

1986
High-performance liquid chromatographic assay for pilocarpine in aqueous humor.
    Journal of chromatography, 1984, Dec-12, Volume: 336, Issue:2

    Topics: Animals; Aqueous Humor; Chromatography, High Pressure Liquid; Isomerism; Male; Pilocarpine; Rabbits

1984
Quantitative determination of pilocarpine, isopilocarpine, pilocarpic acid, and isopilocarpic acid in clinical ophthalmic pilocarpine formulations by reversed-phase liquid chromatography.
    Journal of pharmaceutical sciences, 1981, Volume: 70, Issue:1

    Topics: Chromatography, High Pressure Liquid; Isomerism; Ophthalmic Solutions; Pilocarpine

1981
High-performance liquid chromatographic analysis of pilocarpine hydrochloride, isopilocarpine, pilocarpic acid and isopilocarpic acid in eye-drop preparations.
    Journal of chromatography, 1981, Aug-07, Volume: 212, Issue:3

    Topics: Australia; Chromatography, High Pressure Liquid; Ophthalmic Solutions; Pilocarpine; United States

1981
Determination of pilocarpine in aqueous humour by liquid chromatography-atmospheric pressure chemical ionization mass spectrometry.
    Journal of chromatography, 1993, Nov-24, Volume: 621, Issue:2

    Topics: Animals; Aqueous Humor; Atmospheric Pressure; Chromatography, Liquid; Kinetics; Male; Mass Spectrometry; Pilocarpine; Rabbits

1993
Fractional factorial design optimization of the separation of pilocarpine and its degradation products by capillary electrophoresis.
    Journal of chromatography. B, Biomedical sciences and applications, 1997, Sep-12, Volume: 697, Issue:1-2

    Topics: Electrophoresis, Capillary; Hydrolysis; Miotics; Multivariate Analysis; Pilocarpine; Stereoisomerism

1997
Determination of pilocarpine, isopilocarpine, pilocarpic acid and isopilocarpic acid in human plasma and urine by high-performance liquid chromatography with tandem mass spectrometric detection.
    Journal of chromatography. B, Biomedical sciences and applications, 1998, Apr-24, Volume: 708, Issue:1-2

    Topics: Chromatography, High Pressure Liquid; Evaluation Studies as Topic; Humans; Mass Spectrometry; Pilocarpine; Ultrafiltration

1998
Motor effects of GABA(A) antagonism in globus pallidus: studies of locomotion and tremulous jaw movements in rats.
    Psychopharmacology, 2003, Volume: 170, Issue:2

    Topics: Animals; Behavior, Animal; Bicuculline; Depression, Chemical; Dose-Response Relationship, Drug; Drug Interactions; GABA Antagonists; Globus Pallidus; Haloperidol; Jaw; Locomotion; Male; Movement; Pilocarpine; Rats; Rats, Sprague-Dawley; Tremor

2003
Correlated stage- and subfield-associated hippocampal gene expression patterns in experimental and human temporal lobe epilepsy.
    The European journal of neuroscience, 2003, Volume: 18, Issue:10

    Topics: Animals; Cluster Analysis; Disease Models, Animal; Epilepsy, Temporal Lobe; Gene Expression; Hippocampus; Humans; Male; Oligonucleotide Array Sequence Analysis; Pilocarpine; Rats; Rats, Wistar; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Time Factors

2003
Effects of status epilepticus on hippocampal GABAA receptors are age-dependent.
    Neuroscience, 2004, Volume: 125, Issue:2

    Topics: Age Factors; Animals; Animals, Newborn; Blotting, Northern; Cell Survival; Cerebral Cortex; Dose-Response Relationship, Drug; Drug Interactions; Electroencephalography; GABA Agonists; Gene Expression Regulation; Hippocampus; In Vitro Techniques; Lithium Chloride; Patch-Clamp Techniques; Pilocarpine; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Status Epilepticus; Video Recording; Zolpidem

2004
Strain differences affect the induction of status epilepticus and seizure-induced morphological changes.
    The European journal of neuroscience, 2004, Volume: 20, Issue:2

    Topics: Animals; Cell Count; Hippocampus; Male; Mossy Fibers, Hippocampal; Neurons; Pilocarpine; Rats; Rats, Long-Evans; Rats, Wistar; Reaction Time; Seizures; Species Specificity; Status Epilepticus; Time Factors

2004
Ontogenetic profile of ectonucleotidase activities from brain synaptosomes of pilocarpine-treated rats.
    International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience, 2005, Volume: 23, Issue:8

    Topics: 5'-Nucleotidase; Adenine Nucleotides; Adenosine Triphosphatases; Age Factors; Analysis of Variance; Animals; Animals, Newborn; Cerebral Cortex; Disease Models, Animal; Epilepsy; Female; Hippocampus; Male; Pilocarpine; Rats; Sex Factors; Synaptosomes

2005
Genetic polymorphisms of CYP2A6 affect the in-vivo pharmacokinetics of pilocarpine.
    Pharmacogenetics and genomics, 2008, Volume: 18, Issue:9

    Topics: Administration, Oral; Adult; Aged; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP2A6; Humans; Male; Middle Aged; Muscarinic Agonists; Pilocarpine; Polymorphism, Genetic

2008
Human paraoxonase 1 is the enzyme responsible for pilocarpine hydrolysis.
    Drug metabolism and disposition: the biological fate of chemicals, 2011, Volume: 39, Issue:8

    Topics: Adult; Animals; Aryl Hydrocarbon Hydroxylases; Aryldialkylphosphatase; Calcium Chloride; Cell Line; Cytochrome P-450 CYP2A6; Electrophoresis, Polyacrylamide Gel; Female; Humans; Hydrolysis; Immunoblotting; Insecta; Kinetics; Male; Microsomes, Liver; Middle Aged; Pilocarpine; Polymorphism, Restriction Fragment Length; Substrate Specificity; Transfection; Young Adult

2011
Composition and stability of bacterial communities associated with granular activated carbon and anthracite filters in a pilot scale municipal drinking water treatment facility.
    Journal of water and health, 2012, Volume: 10, Issue:2

    Topics: Bacteria; Carbon; Cities; Coal; Filtration; Pilocarpine; Water Microbiology; Water Purification

2012
Pharmacokinetics of tramadol and its primary metabolite O-desmethyltramadol in African penguins (Spheniscus demersus).
    Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians, 2014, Volume: 45, Issue:1

    Topics: Analgesics, Opioid; Animals; Pilocarpine; Spheniscidae; Tramadol

2014
RANK ligand as a potential target for breast cancer prevention in BRCA1-mutation carriers.
    Nature medicine, 2016, Volume: 22, Issue:8

    Topics: Animals; Bone Density Conservation Agents; BRCA1 Protein; Breast; Breast Neoplasms; Carcinogenesis; Cell Proliferation; Denosumab; Disease Models, Animal; DNA Repair; Female; Flow Cytometry; Heterozygote; Humans; Immunohistochemistry; Mice; Molecular Targeted Therapy; Mutation; Neoplasm Transplantation; Organoids; Pilocarpine; Prophylactic Mastectomy; RANK Ligand; Receptor Activator of Nuclear Factor-kappa B; Reverse Transcriptase Polymerase Chain Reaction; Stem Cells; Tumor Suppressor Proteins; Xenograft Model Antitumor Assays

2016