pilocarpine has been researched along with lithium in 296 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 25 (8.45) | 18.7374 |
| 1990's | 74 (25.00) | 18.2507 |
| 2000's | 83 (28.04) | 29.6817 |
| 2010's | 80 (27.03) | 24.3611 |
| 2020's | 34 (11.49) | 2.80 |
| Authors | Studies |
|---|---|
| Miller, EB; Pain, RW; Skripal, PJ | 1 |
| Lin, TN; MacQuarrie, RA; Navidi, M; Orth, OE; Stubbs, EB; Sun, GY; Yoa, FG | 1 |
| Jope, RS; Kolasa, K; Song, L | 1 |
| Baram, TZ; Hirsch, E; Snead, OC | 1 |
| Chrétien, R; Falter, H; Persinger, MA | 1 |
| Blomme, C; Parker, G; Peredery, O; Persinger, MA | 1 |
| Jope, RS; Kolasa, K; Ormandy, GC; Song, L | 1 |
| Lafreniere, GF; Peredery, O; Persinger, MA | 1 |
| Gilles, F; Hirsch, E; Snead, OC; Vergnes, M | 1 |
| Gale, K; Pazos, A; Peterson, CJ; Vinayak, S | 1 |
| Belmaker, RH; Bersudskey, Y; Kofman, O; Revazov, A | 1 |
| Coyle, JT; Saltarelli, MD; Yamada, K | 1 |
| Kalasapudi, VD; Lachman, HM; Papolos, DF; Weiner, ED | 1 |
| Barnaby, RJ | 1 |
| Gu, X; Jope, RS | 1 |
| Barone, P; Campanella, G; DeBartolomeis, A; Muscettola, G; Palma, V; Tedeschi, E | 1 |
| Jope, RS; Ormandy, GC; Song, L | 1 |
| Harrigan, T; Peredery, O; Persinger, M | 1 |
| Jope, RS; Ormandy, GC | 1 |
| Treiman, DM; Walton, NY | 2 |
| Gunawan, S; Treiman, DM; Walton, NY | 1 |
| Nelson, SR; Padzernik, TL; Terry, JB | 1 |
| Gish, BG; Honchar, MP; Sherman, WR; Vogler, GP | 1 |
| Clifford, DB; Evans, MS; Zorumski, CF | 1 |
| Heal, DJ; Kendall, DA; Whitworth, P | 2 |
| Hamburger-Bar, R; Lerer, B; Roth, D | 1 |
| Jope, RS; Ormandy, GC; Snead, OC | 1 |
| Ferraro, TN; Hare, TA; Jope, RS; Miller, JM | 1 |
| Jope, RS; Morrisett, RA; Snead, OC | 3 |
| Bradley, JC; Makarec, K; Persinger, MA | 1 |
| Jope, RS; Morrisett, RA | 1 |
| Gish, BG; Honchar, MP; Munsell, LY; Sherman, WR | 1 |
| Leigh, JS; Renshaw, PF; Schnall, MD | 1 |
| Ackermann, KE; Gish, BG; Honchar, MP; Sherman, WR | 1 |
| Persinger, MA; Venugopal, M | 1 |
| Clifford, DB; Collins, RC; Maniotis, A; Olney, JW; Zorumski, CF | 1 |
| Meek, JL | 1 |
| Friedman, E; Gianutsos, G | 1 |
| Eglen, RM; Huff, MM; Montgomery, WW; Whiting, RL | 1 |
| Jope, RS; Lally, K; Simonato, M | 1 |
| Lerer, B | 1 |
| Lerer, B; Stanley, M | 1 |
| Bárány, EH; Vale, J | 1 |
| Honchar, MP; Olney, JW; Sherman, WR | 1 |
| Ichikawa, S; Komabayashi, T; Sakamoto, S; Tsuboi, M | 1 |
| Du, F; Eid, T; Köhler, C; Lothman, EW; Schwarcz, R | 1 |
| Jope, RS; Williams, MB | 2 |
| Abdollahi, M; Alghasi, H; Dehpour, AR | 1 |
| Baker, P; Persinger, MA | 1 |
| Bureau, YR; Persinger, MA | 2 |
| Handforth, A; Treiman, DM | 2 |
| Agam, G; Belmaker, RH; Bersudsky, Y; Kofman, O; Shapiro, Y | 1 |
| Belmaker, RH; Katz, V; Kofman, O; Sherman, WR | 1 |
| Daniels, AH; Fujikawa, DG; Kim, JS | 1 |
| Bureau, YR; Peredery, O; Persinger, MA | 1 |
| Persinger, MA | 1 |
| Alpert, C; Belmaker, RH; Bersudsky, Y; Kofman, O; Vinnitsky, I | 1 |
| Kostakos, M; Peredery, O; Persinger, MA | 1 |
| Baldwin, RA; Baxter, CF; Wasterlain, CG | 1 |
| Diamantis, W; Gels, M; Gordon, R; Sofia, RD | 1 |
| Bureau, YR; Falter, H; Kostakos, M; Peredery, O; Persinger, MA | 1 |
| Jope, RS; Unlap, T | 1 |
| Desjardins, D; Persinger, MA | 1 |
| George, B; Kulkarni, SK | 3 |
| Cook, LL; Persinger, MA | 4 |
| Belluardo, N; Condorelli, DF; Jiang, XH; Mudo, G | 1 |
| Sankar, R; Shin, DH; Wasterlain, CG | 1 |
| Gall, CM; Kornblum, HI; Sankar, R; Shin, DH; Wasterlain, CG | 1 |
| Mathé, AA; Miller, JC | 1 |
| Wasterlain, CG | 1 |
| Bureau, YR; Cook, LL; Peredery, O; Persinger, MA | 1 |
| Nagy, AK; Treiman, DM; Walton, NY | 2 |
| Aguiar, LM; de Bruin, VM; de Pinho, RS; de Sousa, FC; Marinho, MM; Viana, GS | 1 |
| Belmaker, RH; Einat, H; Itkin, O; Kofman, O; Lewitan, RJ | 1 |
| Bymaster, FP; Calligaro, DO; Carter, PA; DeLapp, N; Fink-Jensen, A; Jeppesen, L; Mitch, CH; Peters, SC; Rimvall, K; Sauerberg, P; Shannon, HE; Sheardown, MJ; Ward, JS; Whitesitt, CA; Zhang, W | 1 |
| Desjardins, D; Eastman, A; Peredery, O; Persinger, MA | 1 |
| Baram, TZ; Fernandes, MJ; Motte, J; Nehlig, A | 1 |
| Koren, SA; Persinger, MA | 1 |
| Persinger, MA; St Pierre, L | 1 |
| George, B; Kulkarni, SK; Mathur, R | 1 |
| Liu, H; Mazarati, A; Pereira de Vasconcelos, A; Sankar, R; Shin, DH; Wasterlain, CG | 1 |
| André, V; Covolan, L; Dubé, C; Ferrandon, A; Marescaux, C; Nehlig, A | 1 |
| de Bruin, VM; de Sousa, FC; Marinho, MM; Vale, MR; Viana, GS | 1 |
| Boyet, S; Dubé, C; Fernandes, MJ; Marescaux, C; Nehlig, A | 1 |
| Dreyer, EB; Gorla, M; Katowitz, W; Levin, LA; Simon, P; Vorwerk, CK; Zurakowski, D | 1 |
| Cai, B; Fujikawa, DG; Shinmei, SS | 2 |
| Cook, LL | 1 |
| De Bruin, VM; De Sousa, FC; Marinho, MM; Viana, GS | 1 |
| Eraković, V; Laginja, J; Simonić, A; Varljen, J; Zupan, G | 1 |
| Boyet, S; Dubé, C; Marescaux, C; Nehlig, A | 2 |
| Chamberlain, M; Johnson, MP; Kelly, GM | 1 |
| Chopde, CT; Deshmukh, VK; Kasture, VS | 1 |
| André, V; Ferrandon, A; Marescaux, C; Nehlig, A | 2 |
| Dubé, C; Marescaux, C; Nehlig, A | 1 |
| Katsumori, H; Liu, H; Sankar, R; Shin, D; Wasterlain, CG | 1 |
| Mastrosov, L; Parker, G; Peredery, O; Persinger, MA | 1 |
| Güleç, G; Noyan, B | 1 |
| Druga, R; Hlinák, Z; Krsek, P; Mares, P; Mikulecká, A | 1 |
| Chaudhary, G; Gupta, YK | 1 |
| Brandt, C; Ebert, U; Glien, M; Löscher, W; Potschka, H; Voigt, H | 1 |
| André, V; Fritschy, JM; Marescaux, C; Nehlig, A | 1 |
| Ekdahl, CT; Elmér, E; Lindvall, O; Mohapel, P | 1 |
| Hsu, HY; Huang, LT; Lai, MC; Liou, CW; Tung, YR; Wang, TJ; Wu, CL | 1 |
| Bymaster, FP; Calligaro, DO; Carter, PA; DeLapp, NW; Felder, CC | 1 |
| Jedrzejko, C; Persinger, MA | 1 |
| Ferrandon, A; Nehlig, A; Pereira de Vasconcelos, A | 1 |
| Liu, H; Sankar, R; Schreiber, SS; Shin, D; Tan, Z; Tu, W; Wasterlain, CG | 1 |
| Leroy, C; Namer, IJ; Nehlig, A; Roch, C | 1 |
| Chopde, CT; Kasture, SB; Kasture, VS | 1 |
| Liu, KJ; Liu, S; Morrow, D; Peterson, SL | 1 |
| Liu, H; Mazarati, A; Sankar, R; Shin, D; Wasterlain, C | 1 |
| Dubé, C; Koning, E; Nehlig, A | 1 |
| Cha, BH; Holmes, GL; Hu, Y; Liu, X; Silveira, DC | 1 |
| Persinger, MA; St-Pierre, LS | 2 |
| Chambron, J; Mauss, Y; Namer, IJ; Roch, C; Yu, O | 1 |
| Brooks-Kayal, AR; Budreck, EC; Raol, YS | 1 |
| Druga, R; Haugvicová, R; Kubová, H; Suchomelová, L | 1 |
| Bymaster, FP; Carter, PA; Felder, CC; Gomeza, J; Hamilton, SE; McKinzie, DL; Nathanson, NM; Wess, J; Yamada, M | 1 |
| Alm, EM; Galanopoulou, AS; Velísková, J | 1 |
| Cadotte, DW; MacQueen, GM; McEwen, B; Racine, RJ; Wang, JF; Xu, B; Young, LT | 1 |
| Sankar, R; Shin, D; Wasterlain, CG | 1 |
| André, V; Ferrandon, A; Koning, E; Nehlig, A; Rigoulot, MA | 1 |
| Goodkin, HP; Holmes, GL; Liu, X | 1 |
| Koning, E; Leroy, C; Namer, IJ; Nehlig, A; Roch, C | 1 |
| Akman, C; Boukhezra, O; Fu, DD; Holmes, GL; Lui, X; Riviello, P; Zhao, Q | 1 |
| Ferrandon, A; Koning, E; Nehlig, A; Rigoulot, MA | 1 |
| Hsieh, CS; Huang, LT; Lai, MC; Liou, CW; Wang, CA; Wang, CL; Yang, CH; Yang, SN | 1 |
| Fu, DD; Holmes, GL; Hu, Y; Stafstrom, CE; Zhao, Q | 1 |
| Keller, AF; Leroy, C; Nehlig, A; Poisbeau, P | 1 |
| Dupont, MJ; Persinger, MA | 1 |
| Akman, C; Cha, BH; Holmes, GL; Liu, X; Silveira, DC | 1 |
| Griffith, JW; Peterson, SL; Purvis, RS | 2 |
| Koning, E; Nehlig, A; Raffo, E | 1 |
| Peredery, O; Persinger, MA | 1 |
| Fournier, NM; Galic, MA; Martin, LJ | 1 |
| Boissé, L; Heida, JG; Pittman, QJ | 1 |
| McKay, BE; Persinger, MA | 1 |
| Braun, KP; de Graan, PN; Nicolay, K; Notenboom, RG; van Eijsden, P; van Nieuwenhuizen, O; Wu, O | 1 |
| Ferrandon, A; Guenounou, M; Kaplan, H; Koning, E; Motte, J; Nehlig, A; Voutsinos-Porche, B | 1 |
| Bissoon, N; Gurd, JW; Ikeda-Douglas, C; Milgram, NW; Moussa, R; Niimura, M | 1 |
| Desor, D; Detour, J; Nehlig, A; Schroeder, H | 1 |
| Galic, MA; Persinger, MA | 1 |
| Holmes, GL; Hsieh, CS; Huang, LT; Lai, MC; Lee, CH; Lee, KH; Tiao, MM; Wang, CA; Wu, CL; Yang, SN | 1 |
| Dykstra, CM; Gurd, JW; Huo, JZ | 1 |
| Holmes, GL; Marolewski, A; Rusche, JR; Zhao, Q | 1 |
| Brooks-Kayal, AR; Cui, XN; Porter, BE | 1 |
| Ferrandon, A; François, J; Koning, E; Nehlig, A | 1 |
| Brooks-Kayal, AR; Lund, IV; Maronski, MA; Porter, BE; Raol, YH; Zhang, G | 1 |
| Aviles, ER; Fujikawa, DG; Shinmei, SS; Zhao, S | 1 |
| Boehm, N; Hanaya, R; Nehlig, A | 1 |
| Bamidele, A; Begum, S; Choy, M; de Castro, SC; Gadian, DG; Greene, ND; Leung, KY; Lythgoe, MF; Scott, RC; Wait, R | 1 |
| Brown, IR; Lively, S | 2 |
| Bubenik, GA; Parker, GH; Persinger, MA; St-Pierre, LS | 1 |
| Ahmad, M; Deeb, SA; Moutaery, KA; Tariq, M | 1 |
| Feng, HJ; Kao, C; Macdonald, RL; Mathews, GC | 1 |
| Deng, YC; Huang, YG; Li, YN; Shao, XG; Sun, H; Yang, J; Yu, X | 1 |
| Azzam, D; Dbaibo, G; El Dada, S; El Hokayem, J; El Sabban, M; Kobeissi, M; Koubeissi, M; Kurdi, R; Mikati, MA; Rahmeh, A; Rizk, E; Usta, J; Zeinieh, M | 1 |
| Chi, Z; Dai, T; Shan, P; Song, Z; Wang, R; Wang, S | 1 |
| Cheng, JT; Huang, CC; Huang, CW; Tsai, JJ; Wu, SN | 1 |
| Han, SR; Kim, YI; Park, J; Park, S; Rhyu, S; Shin, C | 1 |
| Boehrer, A; de Vasconcelos, AP; Desor, D; Nehlig, A; Raffo, E | 1 |
| Guo, Y; Jiang, L | 1 |
| Cui, XN; Porter, BE; Varodayan, FP; Zhu, XJ | 1 |
| Allen, S; Lopez-Meraz, ML; Niquet, J; Rocha, LL; Wasterlain, CG | 1 |
| Gee, A; Hosoi, R; Inoue, O; Kitano, D; Kuse, K; Momosaki, S | 1 |
| Baldwin, RA; Liu, H; Mazarati, AM; Naylor, DE; Niquet, J; Suchomelova, L; Thompson, KW; Wasterlain, CG | 1 |
| Cheung, KK; Choy, M; Gadian, DG; Lythgoe, MF; Scott, RC; Thomas, DL | 1 |
| Aviles, ER; Fujikawa, DG; Zhao, S | 1 |
| Costa-Ferro, ZS; Cunha, FB; DaCosta, JC; Machado, DC; Pedroso, MF; Ribeiro-dos-Santos, R; Soares, MB; Vitola, AS; Xavier, LL | 1 |
| Hao, A; Huang, Y; Li, L; Liu, J; Wang, A; Xue, P | 1 |
| Cai, GE; Ju, G; Li, ST; Lu, QC; Yang, Q; Zhang, Y | 1 |
| Deng, Y; Feng, D; Huang, Y; Liu, Y; Sun, Z; Wang, H; Wang, W; Zhang, Y; Zhao, G | 1 |
| Battastini, AM; Bonan, CD; da Silveira, VG; de Paula Cognato, G; Figueiró, F; Müller, AP; Perry, ML | 1 |
| Jiang, W; Li, XW; Wang, Y; Wei, D; Zhang, SJ | 1 |
| Feng, L; Hu, K; Li, Y; Long, L; Long, X; Xiao, B; Zhang, C | 1 |
| Su, M; Tong, XX | 1 |
| Liang, LP; Patel, M; Waldbaum, S | 1 |
| Baykara, B; Kurul, SH; Sözmen, SÇ; Tuğyan, K; Yılmaz, O; Yiş, U | 1 |
| Cammarota, M; DaCosta, JC; Greggio, S; Machado, DC; Marinowic, DR; Venturin, GT; Zanirati, G | 1 |
| Damaye, CA; He, F; Lan, Y; Peng, J; Walijee, SM; Wu, L; Yin, F; Zhang, C | 1 |
| Chen, G; Fang, M; Luo, J; Peng, X; Wang, X; Xu, Y; Zhang, X; Zhang, Y; Zhao, F; Zhou, C; Zhu, Q | 1 |
| Chen, H; Hu, Y; Jiang, L | 1 |
| Brandt, C; Löscher, W; Rattka, M | 1 |
| Holmes, GL; Lenck-Santini, PP; Mahoney, JM; Richard, GR; Scott, RC; Tyler, AL | 1 |
| Fang, Y; Li, JL; Li, LY; Wang, K; Wang, Y; Yang, WM; Zhang, HM | 1 |
| Feng, L; Hu, K; Li, Y; Long, HY; Long, LL; Ouyang, DS; Sun, DN; Xiao, B; Xie, YY; Zhang, C | 1 |
| Agam, G; Belmaker, RH; Bersudsky, Y; Shtein, L; Toker, L | 1 |
| Karbowski, LM; Parker, GH; Persinger, MA | 1 |
| Akimana, G; Carneiro, JE; Cassel, JC; Cosquer, B; Faure, JB; Ferrandon, A; Geiger, K; Koning, E; Nehlig, A; Penazzi, L | 1 |
| Chen, H; Cheng, L; Hu, J; Jiang, L; Kong, M; Li, T; Xiong, J; Ye, Y | 1 |
| Dudek, FE; Ekstrand, JJ; Scholl, EA | 1 |
| Banderó, CR; Bankstahl, M; Beltrame, L; Frigerio, F; Löscher, W; Marchini, S; Noe, FM; Polascheck, N; Ravizza, T; Vezzani, A | 1 |
| Beltrán-Parrazal, L; López-Meraz, ML; Manzo, J; Medel-Matus, JS; Morgado-Valle, C; Pérez-Estudillo, C | 1 |
| Chun, KP; Duffy, BA; Lythgoe, MF; Ma, D; Scott, RC | 1 |
| Firouzjaei, MA; Ganjkhani, M; Hemadi, M; Kazemi, M; Moayeri, A; Nejatbakhsh, R; Shokri, S | 1 |
| Hillert, MH; Imran, I; Klein, J; Lau, H; Weinfurter, S; Zimmermann, M | 1 |
| Chen, XN; Fan, XX; Fu, XW; Gu, J; Li, YY; Wang, XF; Wang, ZH; Xiao, Z; Zhang, YJ | 1 |
| Bos, IW; de Graan, PN; Hessel, EV; Mulder, SD; van der Hel, WS; van Eijsden, P; Verlinde, SA | 1 |
| Ahmad, M; Wadaan, MA | 1 |
| Brandt, C; Erker, T; Löscher, W; Töllner, K | 1 |
| Löscher, W | 1 |
| Baldwin, R; Gezalian, M; Niquet, J; Wasterlain, CG | 1 |
| Bascuñana, P; de Cristóbal, J; Delgado, M; Fernández de la Rosa, R; García-García, L; Pozo, MA; Shiha, AA | 1 |
| Årstad, E; Badar, A; Duffy, BA; Lythgoe, MF; Patel, N | 1 |
| Ren, J; Sun, H; Wu, H; Zhan, S; Zhang, G; Zhang, H; Zhang, R | 1 |
| Chen, G; Chen, L; Deng, W; Jiang, G; Li, J; Mi, X; Wang, N; Wang, X; Wang, Z; Zhang, Y | 1 |
| Hillert, MH; Imran, I; Klein, J | 1 |
| Bröer, S; Löscher, W | 1 |
| Bueno-Júnior, LS; Do Val Da Silva, RA; Kandratavicius, L; Leite, JP; Lopes-Aguiar, C; Wolf, DC | 1 |
| Agredano-Moreno, LT; Arriaga-Ávila, V; Carrera-Calvo, D; Córdova-Dávalos, L; Guevara-Guzmán, R; Jiménez-García, LF; Mercado-Gómez, OF; Solís-Navarrete, J | 1 |
| Chen, B; Chen, S; Chen, Z; Fang, Z; Li, Z; Ni, G; Ning, Y; Qin, J; Wu, C; Zhou, J; Zhou, L | 1 |
| Álvarez-Croda, DM; Beltrán-Parrazal, L; López-Meraz, ML; Martínez-Quiroz, J; Medel-Matus, JS; Puig-Lagunes, AA; Santiago-García, J | 1 |
| Gulec Suyen, G; Isbil-Buyukcoskun, N; Kahveci, N; Ozluk, K; Sengun, E | 1 |
| Kim, KK; Kryukov, KA; Magazanik, LG; Zaitsev, AV | 1 |
| Al Ghamdi, S; ALrefai, AA; Alshareef, A; Bin Sef, B; Borham, LE; Ibrahim, IAA; Khan, M; Labib, AA; Mahfoz, AM; Milibary, A; Shahzad, N | 1 |
| Kalemenev, SV; Kim, KK; Lavrent'eva, VV; Lukomskaya, NY; Magazanik, LG; Sizov, VV; Zaitsev, AV; Zubareva, OE | 1 |
| Cai, Y; Cui, L; Li, K; Liu, T; Liu, Z; Tao, H; Wang, Y; Xing, H; Yin, M; Zhao, B; Zhao, J; Zhong, W; Zhou, H; Zhou, X | 1 |
| Karyakin, VB; Magazanik, LG; Vasil'ev, DS; Zaitsev, AV; Zhuravin, IA | 1 |
| de Oliveira, DL; Gonçalves, CA; Hennemann, MM; Vizuete, AFK | 1 |
| Lin, Z; Pan, S; Wang, Y; Xie, L; Yang, T | 1 |
| Celani, MVB; Dos Santos, WF; Gobbo-Neto, L; Godoy, LD; Liberato, JL; Lopes, NP | 1 |
| Cai, Q; Gan, J; Li, S; Luo, R; Mu, D; Qu, Y; Wan, C | 1 |
| Bahremand, T; Dehpour, AR; Eslami, SM; Ghasemi, M; Gholami, M; Momeny, M; Sharifzadeh, M | 1 |
| Qu, Y; Wang, A; Zhang, H | 1 |
| Fukumura, S; Honmou, O; Kataoka-Sasaki, Y; Kocsis, JD; Morita, T; Nagahama, H; Nakazaki, M; Oka, S; Sakai, T; Sasaki, M; Tsutsumi, H | 1 |
| de Oliveira, DL; Gonçalves, CA; Hansen, F; Leite, MC; Negri, E; Vizuete, AFK | 1 |
| Feng, P; Hölscher, C; Li, DF; Tian, MJ; Wang, RF; Xue, GF; Zheng, JY | 1 |
| Ben-Hur, T; Blatch, D; Ekstein, D; Eyal, S; Han, H; Inbar, D; Mann, A; Portnoy, E; Shmuel, M | 1 |
| Chen, SH; Jin, MF; Li, LL; Ni, H | 1 |
| Fan, Z; Feng, X; Yin, S; Zhu, X | 1 |
| Kuang, F; Liu, JT; Wu, SX; Zhang, H | 1 |
| Kim, KK; Lukomskaya, NY; Magazanik, LG; Vataev, SI; Zaitsev, AV | 1 |
| Domínguez-Valentín, AE; Hernández-Moreno, A; Orozco-Suárez, S; Rocha, L; Santana-Gómez, CE; Valle-Dorado, MG | 1 |
| Al Kury, LT; Bogovyk, R; Fedoriuk, M; Isaeva, E; Krishtal, O; Nikolaienko, O; Savotchenko, A; Semenikhina, M | 1 |
| Gao, F; Li, YJ; Wang, L; Yang, CM; Zhang, B | 1 |
| Barker-Haliski, M; DiCamillo, A; Gruner, JA; Hinchliffe, R; Saporito, MS; White, HS | 1 |
| Atilla, P; Aydemir, O; Barun, S; Bulduk, EB; Kiziltas, M; Kurt, G; Muftuoglu, S; Oktem, M; Turhan, T | 1 |
| Chen, L; Chen, S; Hu, K; Huang, Q; Huang, X; Li, C; Ouyang, DS; Wang, X; Zeng, G; Zeng, X; Zhou, L; Zong, W | 1 |
| Chen, Y; Sun, M; van Luijtelaar, G; Wang, J; Wang, Q | 1 |
| Cui, Z; Jia, L; Qu, Z; Si, P; Sun, C; Wang, W; Xie, T; Xue, Y; Zhen, J | 1 |
| Chen, Y; Cheng, W; Huang, Z; Li, S; Lian, Y; Shi, Y; Wang, C; Wang, Y; Wu, S; Xie, N; Zhang, H; Zhang, Q; Zheng, Y | 1 |
| Gao, F; Jia, N; Jia, R; Jiang, W; Jiang, Y; Li, R; Liu, Z; Wang, L; Wu, S; Yang, F; Zhang, H; Zhang, S; Zhang, Z; Zhao, J | 1 |
| Dyomina, AV; Kalemenev, SV; Karepanov, AA; Lavrentyeva, VV; Smolensky, IV; Zaitsev, AV; Zubareva, OE | 1 |
| Alberch, J; Delgado-García, JM; Fernández-García, S; Giralt, A; Gruart, A; Hervé, D; Longueville, S; Sancho-Balsells, A | 1 |
| GuiLian, Z; HaiQin, W; Hong, S; HongWei, R; JiaWen, W; ShuQin, Z; Xin, Y; YongNan, L; Zhen, G | 1 |
| Chen, L; Peng, Y; Qu, Y; Wang, D; Zhu, Y | 1 |
| Chiu, SC; Huang, CW; Lai, MC; Liu, PY; Wu, SN; Yang, CS | 1 |
| Annamalai, K; Kutty, BM; Nair, KP; Salaka, RJ; Shankaranarayana Rao, BS; Srikumar, BN | 1 |
| Charret, TS; Cristina Rheder Fagundes Pascoal, A; Lopes-Cendes, I; Pascoal, VDB; Pereira, MTM | 1 |
| Huang, Y; Li, Y; Luo, X; Ren, S; Wang, L; Wu, G; Wu, J; Wu, Q | 1 |
| Li, S; Luo, X; Ma, M; Wu, Y; Xiang, T; Zeng, C | 1 |
| Albrecht, J; Aldana, BI; Belfiori-Carrasco, LF; Czarnecka, AM; Obara-Michlewska, M; Pawlik, MJ; Popek, MP | 1 |
| Chen, Z; Gu, J; Ma, K; Niu, J; Tao, S; Wang, P; Wang, S; Wei, S; Yang, L; Ye, M; Zhang, G; Zhang, L | 1 |
| Amakhin, DV; Diespirov, GP; Postnikova, TY; Soboleva, EB; Vylekzhanina, EN; Zaitsev, AV | 1 |
| Antonova, IV; Dyomina, AV; Griflyuk, AV; Kovalenko, AA; Postnikova, TY; Smolensky, IV; Zaitsev, AV; Zakharova, MV | 1 |
| Dyomina, AV; Kovalenko, AA; Schwarz, AP; Zaitsev, AV; Zakharova, MV; Zubareva, OE | 1 |
| Dehpour, AR; Eslami, F; Ghasemi, M; Koohfar, A; Maadani, M; Moradi, F; Rahimi, N; Shayan, M | 1 |
| Chen, L; Huang, H; Huang, Q; Niu, J; Ren, J; Su, X; Sun, T; Wan, D; Wang, P; Yang, L; Zhang, C | 1 |
| Amanlou, A; Dehpour, AR; Dejban, P; Eslami, F; Rahimi, N; Shayan, M | 1 |
| Aripaka, SS; Bankstahl, JP; Bankstahl, M; Bascuñana, P; Mikkelsen, JD; Pazarlar, BA | 1 |
| da Silva Oliveira, FA; de Aquino, TM; Dos Santos Júnior, ED; Gitaí, DLG; Landell, MF; Melo, VMM; Oliveira, MET; Paulino, GVB; Shetty, AK; Ursulino, JS | 1 |
| Gupta, YK; Joshi, D; Katyal, J; Kumar, H | 1 |
| Ahmed, N; Ahmed, Y; Alshafei, H; Alshafei, R; Ashraf, N; El-Derany, MO; Ezz, S; George, MY; Ibrahim, C; Ibrahim, SS; Khaled, G; Khaled, H; Saleh, A; Waleed, H; Zaher, M | 1 |
| Li, D; Liu, X; Luo, Z; Qiu, X; Tai, Z; Tuo, J; Wang, J; Xu, Z; Yang, J; Zhang, F; Zhang, H; Zhang, L | 1 |
| Delgado, M; Fernández de la Rosa, R; García-García, L; Gomez, F; Pozo, MÁ | 1 |
| Patial, V; Rahmatkar, SN; Rana, AK; Sharma, S; Singh, D | 1 |
| Baldwin, RA; Niquet, J; Suchomelova, L; Thompson, KW; Wasterlain, CG | 1 |
| Cumbres-Vargas, IM; Pichardo-Macías, LA; Ramírez-San Juan, E; Zamudio, SR | 1 |
| Bolshakov, AP; Borisova, MA; Karan, AA; Suleymanova, EM; Volobueva, MN | 1 |
| Diespirov, GP; Griflyuk, AV; Kovalenko, AA; Postnikova, TY; Zaitsev, AV | 1 |
| Huang, H; Luo, Y; Tai, Z; Xu, Z; Yang, J; Zhang, H; Zhang, L | 1 |
| Bascuñana, P; Delgado, M; García-García, L; Gomez, F; Hernández-Martín, N; Pozo, MÁ; Rosa, RF; Silván, Á | 1 |
| Dyomina, AV; Smolensky, IV; Zaitsev, AV | 1 |
| Banerjee, J; Chandra, PS; Dixit, AB; Dubey, V; Jain, S; Pandey, S; Roy, A; Tripathi, M | 1 |
| Katyal, J; Kumar Gupta, Y; Kumar, H | 1 |
| Castañeda-Morales, JM; Díaz-Vallejo, JJ; Rivadeneyra-Domínguez, E; Rodríguez-Landa, JF; Rosales-Sánchez, Ó; Zamora-Bello, I | 1 |
| Diespirov, GP; Griflyuk, AV; Kalita, AD; Postnikova, TY; Sinyak, DS; Zaitsev, AV; Zubareva, OE | 1 |
3 review(s) available for pilocarpine and lithium
| Article | Year |
|---|---|
Lithium-pilocarpine neurotoxicity: a potential model of status epilepticus.
Topics: Animals; Disease Models, Animal; Lithium; Pilocarpine; Status Epilepticus | 1995 |
Recurrent seizures in the developing brain are harmful.
Topics: Adult; Animals; Brain; Brain Injuries; Child; Disease Models, Animal; Entorhinal Cortex; Epilepsy; Hippocampus; Humans; Lithium; Neural Pathways; Pilocarpine; Rats; Rats, Wistar; Recurrence; Status Epilepticus | 1997 |
Single versus combinatorial therapies in status epilepticus: Novel data from preclinical models.
Topics: Animals; Anticonvulsants; Diazepam; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Therapy, Combination; Excitatory Amino Acid Antagonists; Ketamine; Lithium; Phenobarbital; Pilocarpine; Rats; Seizures; Status Epilepticus | 2015 |
293 other study(ies) available for pilocarpine and lithium
| Article | Year |
|---|---|
Sweat lithium in manic-depression.
Topics: Bipolar Disorder; Humans; Lithium; Pilocarpine; Sweat; Sweating | 1978 |
Lithium effects on inositol phospholipids and inositol phosphates: evaluation of an in vivo model for assessing polyphosphoinositide turnover in brain.
Topics: Animals; Brain; Inositol Phosphates; Lithium; Mecamylamine; Phosphatidylinositols; Pilocarpine; Rats; Rats, Inbred Strains | 1992 |
Inositol trisphosphate, cyclic AMP, and cyclic GMP in rat brain regions after lithium and seizures.
Topics: Animals; Brain Mapping; Cerebral Cortex; Chlorides; Cyclic AMP; Cyclic GMP; Dose-Response Relationship, Drug; Hippocampus; Inositol 1,4,5-Trisphosphate; Lithium; Lithium Chloride; Male; Pilocarpine; Radioligand Assay; Rats; Rats, Inbred Strains; Seizures | 1992 |
Ontogenic study of lithium-pilocarpine-induced status epilepticus in rats.
Topics: Aging; Animals; Animals, Newborn; Cerebral Cortex; Chlorides; Drug Administration Schedule; Electroencephalography; Hippocampus; Lithium; Lithium Chloride; Motor Activity; Pilocarpine; Rats; Rats, Inbred Strains; Reference Values; Status Epilepticus; Stereotyped Behavior; Time Factors | 1992 |
Transient suppression of a secondary humoral response in rats is evoked by lithium-pilocarpine-induced limbic seizures.
Topics: Adrenocorticotropic Hormone; Animals; Antibody Formation; Cyclophosphamide; Limbic System; Lithium; Male; Pilocarpine; Rats; Rats, Wistar; Serum Albumin; Status Epilepticus | 1992 |
Absence of maternal behavior in rats with lithium/pilocarpine seizure-induced brain damage: support of MacLean's triune brain theory.
Topics: Animals; Brain; Brain Mapping; Cerebral Cortex; Chlorides; Electroencephalography; Evoked Potentials; Female; Hypothalamus; Kindling, Neurologic; Limbic System; Lithium; Lithium Chloride; Maternal Behavior; Nerve Degeneration; Pilocarpine; Rats; Rats, Wistar | 1992 |
Seizures selectively impair agonist-stimulated phosphoinositide hydrolysis without affecting protein kinase C activity in rat brain.
Topics: Animals; Brain; Disease Models, Animal; Hippocampus; Hydrolysis; In Vitro Techniques; Lithium; Male; Norepinephrine; Phorbol 12,13-Dibutyrate; Phosphatidylinositols; Pilocarpine; Protein Kinase C; Rats; Rats, Sprague-Dawley; Status Epilepticus | 1992 |
Progressive accumulation of large aggregates of calcium-containing polysaccharides and basophilic debris within specific thalamic nuclei after lithium/pilocarpine-induced seizures.
Topics: Animals; Basophils; Calcium; Histocytochemistry; Lithium; Male; Pilocarpine; Polysaccharides; Rats; Rats, Inbred Strains; Seizures; Spectrophotometry, Atomic; Staining and Labeling; Thalamic Nuclei | 1992 |
Corpus callosotomy in the lithium-pilocarpine model of seizures and status epilepticus.
Topics: Animals; Corpus Callosum; Electroencephalography; Hippocampus; Histocytochemistry; Lithium; Pilocarpine; Rats; Rats, Sprague-Dawley; Seizures; Status Epilepticus | 1992 |
A rodent model of focally evoked self-sustaining status epilepticus.
Topics: Animals; Bicuculline; Diazepam; Disease Models, Animal; Electroencephalography; Lithium; Male; Pilocarpine; Rats; Rats, Sprague-Dawley; Status Epilepticus | 1992 |
Inositol passes the blood brain behavior sufficiently to reverse lithium effects on behavior in rats.
Topics: Animals; Behavior, Animal; Blood-Brain Barrier; Brain Chemistry; Convulsants; Inositol; Lithium; Male; Mannitol; Pilocarpine; Rats | 1992 |
[3H]hemicholinium-3 binding in rats with status epilepticus induced by lithium chloride and pilocarpine.
Topics: Acetylcholine; Animals; Cerebral Cortex; Chlorides; Choline; Hemicholinium 3; Hippocampus; Kinetics; Lithium; Lithium Chloride; Male; Pilocarpine; Rats; Rats, Inbred Strains; Seizures; Status Epilepticus | 1991 |
Lithium augments pilocarpine-induced fos gene expression in rat brain.
Topics: Animals; Brain; Electroshock; Gene Expression; Genes, fos; Lithium; Male; Nucleic Acid Hybridization; Pilocarpine; Rats; Rats, Inbred Strains; Receptors, Muscarinic; RNA | 1991 |
Mass assay for inositol 1-phosphate in rat brain by high-performance liquid chromatography and pulsed amperometric detection.
Topics: Animals; Brain; Brain Chemistry; Chromatography, High Pressure Liquid; Electrochemistry; Inositol Phosphates; Isomerism; Lithium; Pilocarpine; Rats; Rats, Inbred Strains; Reference Values | 1991 |
Seizures increase acetylcholine and choline concentrations in rat brain regions.
Topics: Acetylcholine; Animals; Brain; Choline; Epilepsy; Kainic Acid; Lithium; Male; Pilocarpine; Rats; Rats, Inbred Strains | 1991 |
Dopamine D1 and D2 receptors mediate opposite functions in seizures induced by lithium-pilocarpine.
Topics: Animals; Benzazepines; Dopamine Antagonists; Dose-Response Relationship, Drug; Electroencephalography; Lithium; Male; Pilocarpine; Rats; Rats, Inbred Strains; Receptors, Dopamine; Receptors, Dopamine D1; Receptors, Dopamine D2; Seizures | 1991 |
Analysis of the convulsant-potentiating effects of lithium in rats.
Topics: Animals; Bicuculline; Chlorides; Convulsants; Drug Synergism; Hippocampus; Kainic Acid; Lithium; Lithium Chloride; Male; N-Methylaspartate; Pilocarpine; Rats; Rats, Inbred Strains; Seizures | 1991 |
Radial maze learning deficits and mediodorsal thalamic damage in context of multifocal seizure-induced brain lesions.
Topics: Analysis of Variance; Animals; Brain; Humans; Infant; Learning; Lithium; Memory; Necrosis; Pilocarpine; Rats; Seizures; Task Performance and Analysis | 1991 |
Pertussis toxin potentiates seizures induced by pilocarpine, kainic acid and N-methyl-D-aspartate.
Topics: Adenosine Diphosphate; Adenylyl Cyclases; Animals; Convulsants; Dose-Response Relationship, Drug; Drug Synergism; Enzyme Activation; GTP-Binding Proteins; Injections, Intraventricular; Kainic Acid; Lithium; Male; N-Methylaspartate; Pertussis Toxin; Pilocarpine; Rats; Rats, Inbred Strains; Seizures; Stereotaxic Techniques; Virulence Factors, Bordetella | 1991 |
Motor and electroencephalographic response of refractory experimental status epilepticus in rats to treatment with MK-801, diazepam, or MK-801 plus diazepam.
Topics: Animals; Behavior, Animal; Diazepam; Dizocilpine Maleate; Drug Interactions; Electroencephalography; Lithium; Male; Pilocarpine; Rats; Rats, Inbred Strains; Status Epilepticus | 1991 |
Brain amino acid concentration changes during status epilepticus induced by lithium and pilocarpine.
Topics: Amino Acids; Animals; Aspartic Acid; Brain; Electroencephalography; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Glutamine; Lithium; Male; Pilocarpine; Rats; Rats, Inbred Strains; Status Epilepticus; Tissue Distribution | 1990 |
Effect of LiCl pretreatment on cholinomimetic-induced seizures and seizure-induced brain edema in rats.
Topics: Animals; Brain; Brain Edema; Chlorides; Isoflurophate; Lithium; Lithium Chloride; Male; Organ Specificity; Physostigmine; Pilocarpine; Rats; Rats, Inbred Strains; Reference Values; Seizures | 1990 |
Evidence that phosphoinositide metabolism in rat cerebral cortex stimulated by pilocarpine, physostigmine, and pargyline in vivo is not changed by chronic lithium treatment.
Topics: Animals; Cerebral Cortex; Lithium; Male; Pargyline; Phosphatidylinositols; Physostigmine; Pilocarpine; Rats; Rats, Inbred Strains; Regression Analysis; Stimulation, Chemical; Time Factors | 1990 |
Lithium enhances neuronal muscarinic excitation by presynaptic facilitation.
Topics: Animals; Drug Interactions; Electrophysiology; Epilepsy; In Vitro Techniques; Lithium; Male; Muscarine; Neural Inhibition; Neurons; Pilocarpine; Rats; Rats, Inbred Strains; Second Messenger Systems; Synapses; Synaptic Transmission | 1990 |
The effects of acute and chronic lithium treatment on pilocarpine-stimulated phosphoinositide hydrolysis in mouse brain in vivo.
Topics: Animals; Atropine; Brain; Diet; Hydrolysis; In Vitro Techniques; Inositol; Inositol 1,4,5-Trisphosphate; Lithium; Male; Mice; Mice, Inbred C57BL; Phosphatidylinositols; Pilocarpine | 1990 |
Peripheral versus central manifestations in the toxic interaction of lithium and pilocarpine.
Topics: Animals; Brain; Chlorides; Cholinergic Fibers; Dose-Response Relationship, Drug; Drug Synergism; Lithium; Lithium Chloride; Male; N-Methylscopolamine; Peripheral Nerves; Pilocarpine; Rats; Rats, Inbred Strains; Scopolamine; Scopolamine Derivatives | 1989 |
Anticonvulsant actions of MK-801 on the lithium-pilocarpine model of status epilepticus in rats.
Topics: Animals; Anticonvulsants; Aspartic Acid; Cerebral Cortex; Dibenzocycloheptenes; Dizocilpine Maleate; Dose-Response Relationship, Drug; Drug Synergism; Electroencephalography; Hippocampus; Lithium; Male; N-Methylaspartate; Pilocarpine; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Status Epilepticus | 1989 |
Chronic lithium treatment and status epilepticus induced by lithium and pilocarpine cause selective changes of amino acid concentrations in rat brain regions.
Topics: Amino Acids; Animals; Brain; Cerebral Cortex; Corpus Striatum; Hippocampus; Lithium; Male; Pilocarpine; Rats; Rats, Inbred Strains; Status Epilepticus; Substantia Nigra | 1989 |
Chronic lithium treatment enhances inositol polyphosphate formation in mouse brain in vivo.
Topics: Animals; Brain Chemistry; Inositol Phosphates; Lithium; Male; Mice; Mice, Inbred C57BL; Pilocarpine | 1989 |
Status epilepticus is produced by administration of cholinergic agonists to lithium-treated rats: comparison with kainic acid.
Topics: Animals; Arecoline; Chlorides; Dose-Response Relationship, Drug; Drug Synergism; Electroencephalography; Kainic Acid; Lithium; Lithium Chloride; Male; Physostigmine; Pilocarpine; Rats; Rats, Inbred Strains; Status Epilepticus | 1987 |
Characteristics of limbic seizures evoked by peripheral injections of lithium and pilocarpine.
Topics: Animals; Anticonvulsants; Brain Mapping; Chlorides; Dose-Response Relationship, Drug; Drug Synergism; Electroencephalography; Evoked Potentials; Female; Limbic System; Lithium; Lithium Chloride; Male; Pilocarpine; Rats; Rats, Inbred Strains; Reaction Time; Receptors, Cholinergic; Seizures; Sex Factors; Stereotyped Behavior | 1988 |
Neurochemical consequences of status epilepticus induced in rats by coadministration of lithium and pilocarpine.
Topics: Acetylcholine; Animals; Brain; Choline; Cyclic GMP; Decerebrate State; Drug Combinations; Lithium; Male; Nervous System; Osmolar Concentration; Pilocarpine; Rats; Rats, Inbred Strains; Status Epilepticus; Tissue Distribution | 1986 |
Effects of lithium on phosphoinositide metabolism in vivo.
Topics: Animals; Bipolar Disorder; Brain; Cerebral Cortex; Guinea Pigs; Humans; In Vitro Techniques; Kinetics; Lithium; Mice; Phosphatidylinositols; Phosphoric Monoester Hydrolases; Pilocarpine; Rats; Type C Phospholipases | 1986 |
In vivo 31P NMR spectroscopy of agonist-stimulated phosphatidylinositol metabolism in cat brain.
Topics: Animals; Brain; Cats; Chlorides; Inositol Phosphates; Lithium; Lithium Chloride; Magnetic Resonance Spectroscopy; Male; Pilocarpine; Receptors, Muscarinic; Sugar Phosphates | 1987 |
Evidence that inositol 1-phosphate in brain of lithium-treated rats results mainly from phosphatidylinositol metabolism.
Topics: Animals; Cattle; Cerebral Cortex; Chlorides; Dose-Response Relationship, Drug; Hydrolysis; In Vitro Techniques; Inositol Phosphates; Kinetics; Lithium; Lithium Chloride; Phosphatidylinositols; Phosphoric Monoester Hydrolases; Pilocarpine; Sugar Phosphates | 1987 |
Response of status epilepticus induced by lithium and pilocarpine to treatment with diazepam.
Topics: Analysis of Variance; Animals; Diazepam; Electroencephalography; Lithium; Pilocarpine; Reaction Time; Status Epilepticus | 1988 |
Conditioned taste aversion is reduced in rats with a history of lithium/pilocarpine-induced limbic seizures.
Topics: Animals; Avoidance Learning; Conditioning, Classical; Limbic System; Lithium; Male; Pilocarpine; Rats; Rats, Inbred Strains; Seizures; Taste | 1988 |
The functional anatomy and pathology of lithium-pilocarpine and high-dose pilocarpine seizures.
Topics: Animals; Behavior, Animal; Brain; Deoxyglucose; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Injections, Subcutaneous; Lithium; Male; Pilocarpine; Rats; Rats, Inbred Strains; Seizures | 1987 |
Inositol bis-, tris-, and tetrakis(phosphate)s: analysis in tissues by HPLC.
Topics: Animals; Brain Chemistry; Chromatography, High Pressure Liquid; Inositol Phosphates; Lithium; Male; Pilocarpine; Rats; Salivary Glands; Sugar Phosphates; Time Factors; Tissue Distribution | 1986 |
Prevention of fluphenazine-induced changes in dopaminergic and muscarinic receptors by lithium.
Topics: Animals; Atropine Derivatives; Corpus Striatum; Fluphenazine; Hippocampus; Kinetics; Lithium; Male; Mice; Pilocarpine; Receptors, Dopamine; Receptors, Muscarinic | 1987 |
Effects of drugs on the initiation and maintenance of status epilepticus induced by administration of pilocarpine to lithium-pretreated rats.
Topics: Animals; Anticonvulsants; Atropine; Diazepam; Electroencephalography; Lithium; Male; Paraldehyde; Phenylisopropyladenosine; Pilocarpine; Rats; Rats, Inbred Strains; Status Epilepticus; Theophylline | 1987 |
Differential effects of pertussis toxin and lithium on muscarinic responses in the atria and ileum: evidence for receptor heterogeneity.
Topics: Adenylate Cyclase Toxin; Animals; Bethanechol Compounds; Carbachol; Guinea Pigs; Ileum; In Vitro Techniques; Lithium; Male; Muscle, Smooth; Myocardium; Pertussis Toxin; Pilocarpine; Receptors, Muscarinic; Virulence Factors, Bordetella | 1987 |
Acetylcholine content in rat brain is elevated by status epilepticus induced by lithium and pilocarpine.
Topics: Acetylcholine; Acetylcholinesterase; Animals; Atropine; Brain; Choline; Lithium; Male; Pilocarpine; Rats; Rats, Inbred Strains; Status Epilepticus | 1987 |
Studies on the role of brain cholinergic systems in the therapeutic mechanisms and adverse effects of ECT and lithium.
Topics: Animals; Behavior, Animal; Body Temperature Regulation; Brain; Electroconvulsive Therapy; Lithium; Lithium Carbonate; Male; Mental Recall; Motor Activity; Pilocarpine; Quinuclidinyl Benzilate; Rats; Rats, Inbred Strains; Receptors, Cholinergic; Receptors, Muscarinic; Scopolamine Derivatives | 1985 |
Characterization of lithium potentiation of pilocarpine-induced status epilepticus in rats.
Topics: Animals; Atropine; Diazepam; Drug Synergism; Electroencephalography; Hemicholinium 3; Lithium; Male; Pilocarpine; Rats; Rats, Inbred Strains; Status Epilepticus | 1986 |
Effect of chronic lithium on cholinergically mediated responses and [3H]QNB binding in rat brain.
Topics: Animals; Brain; Catalepsy; Cholinergic Fibers; Hypothermia, Induced; Lithium; Male; Pilocarpine; Quinuclidinyl Benzilate; Rats; Rats, Inbred Strains; Receptors, Muscarinic; Scopolamine | 1985 |
Effects of phenylephrine, butylsympatol, pilocarpine, and lithium on runout of 86Rb from isolated rabbit ciliary processes.
Topics: Acetazolamide; Animals; Biological Transport, Active; Calcium; Ciliary Body; Ethanolamines; Glucose; In Vitro Techniques; Lithium; Oxygen; Phenylephrine; Pilocarpine; Potassium; Rabbits; Radioisotopes; Rubidium; Sodium; Temperature | 1969 |
Systemic cholinergic agents induce seizures and brain damage in lithium-treated rats.
Topics: Animals; Atropine; Brain Chemistry; Chlorides; Drug Interactions; Humans; Inositol; Inositol Phosphates; Lithium; Lithium Chloride; Male; Parasympathomimetics; Physostigmine; Pilocarpine; Rats; Rats, Inbred Strains; Seizures; Substance-Related Disorders | 1983 |
[Effects of adrenaline, noradrenaline and pilocarpine on the oxygen uptake in rat submandibular gland (author's transl)].
Topics: Animals; Calcium; Choline; Dose-Response Relationship, Drug; Epinephrine; In Vitro Techniques; Lanthanum; Lithium; Male; Norepinephrine; Oxygen Consumption; Pilocarpine; Rats; Rats, Inbred Strains; Sodium; Submandibular Gland | 1981 |
Preferential neuronal loss in layer III of the medial entorhinal cortex in rat models of temporal lobe epilepsy.
Topics: Animals; Behavior, Animal; Cell Death; Electric Stimulation; Entorhinal Cortex; Epilepsy, Temporal Lobe; Kainic Acid; Lithium; Male; Neurons; Pilocarpine; Rats; Rats, Sprague-Dawley; Status Epilepticus | 1995 |
Modulation by inositol of cholinergic- and serotonergic-induced seizures in lithium-treated rats.
Topics: Amphetamines; Animals; Cholinergic Agents; Drug Synergism; Inositol; Lithium; Male; Pilocarpine; Rats; Rats, Sprague-Dawley; Seizures; Serotonin Receptor Agonists | 1995 |
Effects of lithium on rat parotid and submandibulary gland functions.
Topics: Animals; Calcium; Lithium; Male; Organ Size; Parotid Gland; Pilocarpine; Potassium; Rats; Rats, Sprague-Dawley; Salivary Proteins and Peptides; Salivation; Sodium; Submandibular Gland | 1995 |
Early genital stimulation of rats lowers limbic seizure latencies for females but increases latencies for males.
Topics: Animals; Animals, Newborn; Arousal; Electroencephalography; Female; Genitalia, Female; Genitalia, Male; Limbic System; Lithium; Male; Mechanoreceptors; Pilocarpine; Rats; Rats, Wistar; Reaction Time; Seizures; Sexual Maturation | 1995 |
Decreased latencies for limbic seizures induced in rats by lithium-pilocarpine occur when daily average geomagnetic activity exceeds 20 nanoTesla.
Topics: Animals; Differential Threshold; Earth, Planet; Limbic System; Lithium; Magnetics; Male; Pilocarpine; Rats; Rats, Wistar; Reaction Time; Seizures | 1995 |
Functional mapping of the early stages of status epilepticus: a 14C-2-deoxyglucose study in the lithium-pilocarpine model in rat.
Topics: Animals; Autoradiography; Brain; Carbon Radioisotopes; Deoxyglucose; Disease Models, Animal; Electroencephalography; Lithium; Male; Pilocarpine; Rats; Rats, Sprague-Dawley; Seizures; Status Epilepticus | 1995 |
Functional mapping of the late stages of status epilepticus in the lithium-pilocarpine model in rat: a 14C-2-deoxyglucose study.
Topics: Animals; Brain Mapping; Carbon Radioisotopes; Deoxyglucose; Electroencephalography; Lithium; Male; Pilocarpine; Rats; Rats, Sprague-Dawley; Status Epilepticus | 1995 |
High-dose peripheral inositol raises brain inositol levels and reverses behavioral effects of inositol depletion by lithium.
Topics: Animals; Behavior, Animal; Brain Chemistry; Cerebral Cortex; Chromatography, Gas; Glucose; Injections, Intraperitoneal; Injections, Intraventricular; Inositol; Lithium; Male; Pilocarpine; Rats; Rats, Sprague-Dawley; Seizures | 1994 |
Restoration of brain myo-inositol levels in rats increases latency to lithium-pilocarpine seizures.
Topics: Animals; Behavior, Animal; Brain Chemistry; Cerebral Cortex; Epilepsy, Tonic-Clonic; Injections, Intraventricular; Inositol; Lithium; Male; Pilocarpine; Rats; Rats, Sprague-Dawley; Seizures | 1993 |
The competitive NMDA receptor antagonist CGP 40116 protects against status epilepticus-induced neuronal damage.
Topics: 2-Amino-5-phosphonovalerate; Animals; Anticonvulsants; Behavior, Animal; Brain; Diazepam; Electroencephalography; Lithium; Male; Neurons; Phenobarbital; Pilocarpine; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Status Epilepticus | 1994 |
Concordance of quantitative damage within the diencephalon and telencephalon following systemic pilocarpine (380 mg/kg) or lithium (3 mEq/kg)/pilocarpine (30 mg/kg) induced seizures.
Topics: Acepromazine; Animals; Diencephalon; Lithium; Male; Muscarinic Agonists; Necrosis; Pilocarpine; Rats; Rats, Wistar; Seizures; Telencephalon; Tissue Fixation | 1994 |
Distinctive rat brain immediate early gene responses to seizures induced by lithium plus pilocarpine.
Topics: Animals; Cerebral Cortex; Diazepam; Dizocilpine Maleate; Hippocampus; Lithium; Male; Pilocarpine; Rats; Rats, Sprague-Dawley; Seizures; Transcription, Genetic | 1994 |
Maintained hypersexuality between male rats following chronically induced limbic seizures: implications for bisexuality in complex partial epileptic seizures.
Topics: Animals; Bisexuality; Hippocampus; Limbic System; Lithium; Male; Pilocarpine; Rats; Rats, Wistar; Seizures; Sexual Behavior, Animal | 1994 |
The effect of peripheral inositol injection on rat motor activity models of depression.
Topics: Amphetamine; Analysis of Variance; Animals; Apomorphine; Depression; Disease Models, Animal; Drug Synergism; Glucose; Inositol; Lithium; Male; Motor Activity; Pilocarpine; Rats; Rats, Sprague-Dawley; Seizures; Stereotyped Behavior | 1993 |
Deficits in working but not reference memory in adult rats in which limbic seizures had been induced before weaning: implications for early brain injuries.
Topics: Animals; Brain Injuries; Limbic System; Lithium; Male; Memory; Memory Disorders; Memory, Short-Term; Pilocarpine; Rats; Rats, Wistar; Seizures; Thalamus; Weaning | 1993 |
Extreme hypothermia induced by a synergism of acute limbic seizures, physical restraint, and acepromazine: implications for survival following brain injury.
Topics: Acepromazine; Animals; Body Temperature Regulation; Brain Injuries; Chlorides; Hypothermia; Limbic System; Lithium; Lithium Chloride; Male; Neurons; Pilocarpine; Rats; Restraint, Physical; Seizures; Status Epilepticus | 1993 |
GABA metabolism in the substantia nigra, cortex, and hippocampus during status epilepticus.
Topics: Amino Acids; Aminocaproates; Animals; Cerebral Cortex; gamma-Aminobutyric Acid; Hippocampus; Lithium; Male; Parietal Lobe; Pilocarpine; Rats; Rats, Sprague-Dawley; Status Epilepticus; Substantia Nigra; Vigabatrin | 1993 |
Effects of felbamate and other anticonvulsant drugs in two models of status epilepticus in the rat.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Epilepsy; Felbamate; Lithium; Male; Phenylcarbamates; Pilocarpine; Propylene Glycols; Rats; Rats, Sprague-Dawley; Seizures; Status Epilepticus | 1993 |
Behaviors of rats with insidious, multifocal brain damage induced by seizures following single peripheral injections of lithium and pilocarpine.
Topics: Acetylcholine; Aggression; Animals; Association Learning; Avoidance Learning; Brain; Brain Damage, Chronic; Calcium; Conditioning, Classical; Discrimination Learning; Drug Synergism; Electroencephalography; Female; Glycosaminoglycans; Limbic System; Lithium; Male; Mental Recall; Necrosis; Nerve Degeneration; Orientation; Pain Threshold; Pilocarpine; Rats; Rats, Wistar; Reaction Time; Seizures; Taste | 1993 |
Inhibition of NFkB DNA binding activity by glucocorticoids in rat brain.
Topics: Adrenalectomy; Animals; Base Sequence; Brain Chemistry; Cerebral Cortex; DNA; Excitatory Amino Acid Agonists; Glucocorticoids; Hippocampus; Kainic Acid; Lithium; Male; Molecular Sequence Data; Muscarinic Agonists; NF-kappa B; Oxidative Stress; Pilocarpine; Rats; Rats, Sprague-Dawley; Transcription Factor AP-1 | 1995 |
Association between intermale social aggression and cellular density within the central amygdaloid nucleus in rats with lithium/pilocarpine-induced seizures.
Topics: Aggression; Amygdala; Animals; Behavior, Animal; Lithium; Male; Muscarinic Agonists; Neuroglia; Neurons; Pilocarpine; Rats; Seizures; Social Behavior; Tranquilizing Agents | 1995 |
Demands during maze. learning in limbic epileptic rats: selective damage in the thalamus?
Topics: Animals; Attention; Brain Mapping; Cell Count; Epilepsy; Limbic System; Lithium; Male; Maze Learning; Mental Recall; Nerve Degeneration; Neuroglia; Neuronal Plasticity; Neurons; Pilocarpine; Rats; Rats, Wistar; Thalamic Nuclei | 1996 |
Long-term consequences of subtle stimuli during the first twenty-four hours of seizure-induced brain injury.
Topics: Acetates; Amines; Animals; Anticonvulsants; Appetitive Behavior; Brain Damage, Chronic; Cholinergic Fibers; Cyclohexanecarboxylic Acids; Dominance, Cerebral; Electromagnetic Fields; Gabapentin; gamma-Aminobutyric Acid; Limbic System; Lithium; Male; Maze Learning; Mental Recall; Pilocarpine; Prednisolone; Rats; Seizures | 1996 |
Induction of astroglial gene expression by experimental seizures in the rat: spatio-temporal patterns of the early stages.
Topics: Animals; Astrocytes; Behavior, Animal; Brain; Brain Chemistry; Convulsants; Excitatory Amino Acid Agonists; Gene Expression; Glial Fibrillary Acidic Protein; In Situ Hybridization; Injections, Intraventricular; Kainic Acid; Lithium; Male; Pilocarpine; Rats; Rats, Wistar; RNA, Messenger; Status Epilepticus; Time Factors | 1996 |
GABA metabolism during status epilepticus in the developing rat brain.
Topics: Age Factors; Animals; gamma-Aminobutyric Acid; Hippocampus; Lithium; Muscarinic Agonists; Parietal Lobe; Pilocarpine; Rats; Rats, Wistar; Status Epilepticus | 1997 |
Induction of brain derived neurotrophic factor mRNA by seizures in neonatal and juvenile rat brain.
Topics: Animals; Animals, Newborn; Brain; Brain-Derived Neurotrophic Factor; Kainic Acid; Lithium; Pilocarpine; Rats; Rats, Wistar; RNA, Messenger; Seizures | 1997 |
Basal and stimulated C-fos mRNA expression in the rat brain: effect of chronic dietary lithium.
Topics: Amino Acid Isomerases; Animals; Blotting, Northern; Brain Chemistry; Carrier Proteins; Cholinergic Agonists; Diet; Dopamine Antagonists; Haloperidol; Lithium; Male; Peptidylprolyl Isomerase; Pilocarpine; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; RNA, Messenger; Stress, Psychological; Substance Withdrawal Syndrome | 1997 |
Emergent properties following brain injury: the claustrum as a major component of a pathway that influences nociceptive thresholds to foot shock in rats.
Topics: Animals; Basal Ganglia; Behavior, Animal; Brain; Brain Injuries; Disease Models, Animal; Electroshock; Foot; Lithium; Neural Pathways; Nociceptors; Pain Threshold; Pilocarpine; Rats; Seizures | 1997 |
Reduced cortical ecto-ATPase activity in rat brains during prolonged status epilepticus induced by sequential administration of lithium and pilocarpine.
Topics: Adenosine Triphosphatases; Analysis of Variance; Animals; Cerebral Cortex; Chronic Disease; Drug Administration Schedule; Lithium; Male; Pilocarpine; Rats; Rats, Sprague-Dawley; Status Epilepticus; Synaptosomes | 1997 |
Modulation of lithium-pilocarpine-induced status epilepticus by adenosinergic agents.
Topics: 2-Chloroadenosine; Adenosine; Animals; Anticonvulsants; Carbamazepine; Dipyridamole; Disease Models, Animal; Dose-Response Relationship, Drug; Lithium; Male; Pilocarpine; Rats; Rats, Wistar; Status Epilepticus; Theophylline; Vasodilator Agents | 1997 |
Inhibitory action of a calcium channel blocker (nimodipine) on seizures and brain damage induced by pilocarpine and lithium-pilocarpine in rats.
Topics: Animals; Atropine; Brain Diseases; Lithium; Male; Nimodipine; Pilocarpine; Rats; Rats, Wistar; Seizures; Status Epilepticus | 1997 |
Dopaminergic modulation of lithium/pilocarpine-induced status epilepticus in rats.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Azepines; Benzazepines; Disease Models, Animal; Dopamine Agonists; Dopamine Antagonists; Haloperidol; Lipid Peroxidation; Lithium; Male; Muscarinic Agonists; Pilocarpine; Rats; Rats, Wistar; Status Epilepticus; Sulpiride | 1997 |
Augmentation of lithium's behavioral effect by inositol uptake inhibitors.
Topics: Animals; Depsipeptides; Drug Synergism; Fucose; Injections, Intraventricular; Inositol; Lithium; Male; Peptides, Cyclic; Pilocarpine; Rats; Rats, Sprague-Dawley; Seizures | 1998 |
Xanomeline compared to other muscarinic agents on stimulation of phosphoinositide hydrolysis in vivo and other cholinomimetic effects.
Topics: Animals; Binding, Competitive; Brain Chemistry; Bridged Bicyclo Compounds, Heterocyclic; Cholinergic Agents; Cholinesterase Inhibitors; Dihydropyridines; Dose-Response Relationship, Drug; Hydrolysis; Hypothermia; Imines; Lithium; Male; Mice; Mice, Inbred Strains; Muscarinic Agonists; Oximes; Parasympathomimetics; Phosphatidylinositols; Physostigmine; Pilocarpine; Pyridines; Quinuclidines; Radioligand Assay; Salivation; Tacrine; Tetrazoles; Thiadiazoles; Tremor | 1998 |
Ventricular dilation over several weeks following induction of excitotoxic (systemic lithium/pilocarpine) lesions: potential role of damage to the substantia nigra reticulata.
Topics: Animals; Atrophy; Brain; Cerebral Ventricles; Lithium; Male; Nerve Degeneration; Neurotoxins; Pilocarpine; Rats; Rats, Wistar; Seizures; Substantia Nigra; Thalamus; Time Factors | 1998 |
Spatial and temporal evolution of neuronal activation, stress and injury in lithium-pilocarpine seizures in adult rats.
Topics: Animals; Behavior, Animal; Brain Injuries; Electroencephalography; Lithium; Male; Neurons; Pilocarpine; Rats; Rats, Sprague-Dawley; Seizures; Status Epilepticus; Stress, Physiological; Time Factors | 1998 |
Persistent elevation of nocturnal activity in rodents following apparent recovery from lithium/pilocarpine-induced limbic seizures.
Topics: Animals; Behavior, Animal; Brain; Circadian Rhythm; Epilepsy; Limbic System; Lithium; Male; Melatonin; Pilocarpine; Rats; Rats, Wistar | 1998 |
"Subclinical" dosages of lithium and pilocarpine that do not evoke overt seizures affect long-term spatial memory but not learning in rats.
Topics: Animals; Behavior, Animal; Conditioning, Operant; Dose-Response Relationship, Drug; Injections, Subcutaneous; Lithium; Male; Maze Learning; Memory; Pilocarpine; Rats; Rats, Wistar; Seizures; Sodium Chloride | 1998 |
Geophysical variables and behavior: LXXXIV. Quantitative increases in group aggression in male epileptic rats during increases in geomagnetic activity.
Topics: Aggression; Animals; Behavior, Animal; Epilepsy; Geography; Limbic System; Lithium; Magnetics; Male; Periodicity; Pilocarpine; Rats | 1998 |
Development of self-sustaining limbic status epilepticus by continuous ventral hippocampal stimulation followed by low dose pilocarpine in rats.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Dizocilpine Maleate; Electroencephalography; Hippocampus; Limbic System; Lithium; Male; Neuroprotective Agents; Phenobarbital; Pilocarpine; Rats; Rats, Wistar; Seizures; Status Epilepticus; Stereotyped Behavior | 1998 |
Patterns of status epilepticus-induced neuronal injury during development and long-term consequences.
Topics: Age Factors; Animals; Apoptosis; Behavior, Animal; DNA; Electroencephalography; Female; In Situ Nick-End Labeling; Lithium; Male; Microscopy, Electron; Mossy Fibers, Hippocampal; Muscarinic Agonists; Neuronal Plasticity; Neurons; Pilocarpine; Rats; Rats, Wistar; Status Epilepticus; Synapses | 1998 |
C-Fos, Jun D and HSP72 immunoreactivity, and neuronal injury following lithium-pilocarpine induced status epilepticus in immature and adult rats.
Topics: Age Factors; Animals; Brain Stem; Cerebral Cortex; Female; Heat-Shock Proteins; Hippocampus; HSP72 Heat-Shock Proteins; Lithium; Male; Mesencephalon; Muscarinic Agonists; Nerve Degeneration; Neurons; Pilocarpine; Pregnancy; Prosencephalon; Proto-Oncogene Proteins c-fos; Proto-Oncogene Proteins c-jun; Rats; Rats, Sprague-Dawley; Silver Staining; Status Epilepticus; Thalamus | 1998 |
Effects of lithium, alone or associated with pilocarpine, on muscarinic and dopaminergic receptors and on phosphoinositide metabolism in rat hippocampus and striatum.
Topics: Animals; Atropine; Brain; Corpus Striatum; Drug Synergism; Hippocampus; Lithium; Male; Muscarinic Agonists; Muscarinic Antagonists; Phosphatidylinositols; Pilocarpine; Rats; Rats, Wistar; Receptors, Dopamine; Receptors, Muscarinic | 1998 |
Correlation between hypermetabolism and neuronal damage during status epilepticus induced by lithium and pilocarpine in immature and adult rats.
Topics: Aging; Animals; Animals, Newborn; Behavior, Animal; Brain; Glucose; Lactic Acid; Lithium; Male; Nerve Degeneration; Neurons; Pilocarpine; Rats; Rats, Sprague-Dawley; Status Epilepticus | 1999 |
Pilocarpine toxicity in retinal ganglion cells.
Topics: Animals; Cell Survival; Cells, Cultured; Dose-Response Relationship, Drug; Drug Synergism; Inositol; Lithium; Pilocarpine; Rats; Rats, Long-Evans; Retinal Ganglion Cells | 1999 |
Lithium-pilocarpine-induced status epilepticus produces necrotic neurons with internucleosomal DNA fragmentation in adult rats.
Topics: Age Factors; Animals; Apoptosis; Cell Nucleolus; Dentate Gyrus; DNA Fragmentation; In Situ Nick-End Labeling; Lithium; Male; Muscarinic Agonists; Necrosis; Neurons; Pilocarpine; Rats; Rats, Wistar; Status Epilepticus | 1999 |
Altered residual ATP content in rat brain cortex subcellular fractions following status epilepticus induced by lithium and pilocarpine.
Topics: Adenosine Triphosphate; Animals; Cell Fractionation; Cell Membrane; Cerebral Cortex; Cytosol; Hydrolysis; Lithium; Male; Matched-Pair Analysis; Mitochondria; Phosphates; Pilocarpine; Proton-Translocating ATPases; Rats; Rats, Sprague-Dawley; Status Epilepticus; Synaptosomes; Time Factors | 1998 |
Ventricular enlargement and the lithium/pilocarpine seizure model: possible explanation for agonistic behaviour.
Topics: Acepromazine; Agonistic Behavior; Animals; Anticonvulsants; Ketamine; Lateral Ventricles; Lithium; Male; Pilocarpine; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Seizures | 2000 |
Infiltration of lymphocytes in the limbic brain following stimulation of subclinical cellular immunity and low dosages of lithium and a cholinergic agent.
Topics: Animals; Cholinergic Agents; Female; Immunity, Cellular; Limbic System; Lithium; Lymphocytes; Male; Neurons; Parasympathomimetics; Pilocarpine; Rats; Rats, Inbred Lew; Seizures | 1999 |
Behavioral and neurochemical alterations after lithium-pilocarpine administration in young and adult rats: a comparative study.
Topics: Age Factors; Animals; Atropine; Behavior, Animal; Brain; Lithium; Male; N-Methylscopolamine; Pilocarpine; Rats; Rats, Wistar; Receptors, Dopamine; Receptors, Muscarinic; Spiperone | 2000 |
Lithium plus pilocarpine induced status epilepticus--biochemical changes.
Topics: Animals; Brain; Female; Lithium; Pilocarpine; Rats; Rats, Wistar; Status Epilepticus | 2000 |
Progressive metabolic changes underlying the chronic reorganization of brain circuits during the silent phase of the lithium-pilocarpine model of epilepsy in the immature and adult Rat.
Topics: Age Factors; Animals; Behavior, Animal; Benzoxazines; Brain Stem; Carbon Radioisotopes; Cell Death; Cerebral Cortex; Coloring Agents; Deoxyglucose; Disease Models, Animal; Epilepsy, Temporal Lobe; Female; Glucose; Lithium; Male; Muscarinic Agonists; Nerve Degeneration; Neural Pathways; Oxazines; Pilocarpine; Pregnancy; Rats; Rats, Sprague-Dawley; Silver Staining; Synapses; Time Factors | 2000 |
Blockade of pilocarpine-induced cerebellar phosphoinositide hydrolysis with metabotropic glutamate antagonists: evidence for an indirect control of granule cell glutamate release by muscarinic agonists.
Topics: Amino Acids; Animals; Cerebellum; Corpus Striatum; Frontal Lobe; Hippocampus; Hydrolysis; Lithium; Male; Muscarinic Agonists; Phosphatidylinositols; Pilocarpine; Rats; Rats, Sprague-Dawley; Receptor, Muscarinic M2; Receptors, Metabotropic Glutamate; Receptors, Muscarinic; Scopolamine; Xanthenes | 2000 |
Anticonvulsive activity of Albizzia lebbeck, Hibiscus rosa sinesis and Butea monosperma in experimental animals.
Topics: Amphetamine; Animals; Anticonvulsants; Behavior, Animal; Brain Chemistry; Central Nervous System Stimulants; Convulsants; Electroshock; Epilepsy; gamma-Aminobutyric Acid; Hypnotics and Sedatives; Lithium; Male; Mice; Muscarinic Agonists; Pentobarbital; Pentylenetetrazole; Pilocarpine; Plant Extracts; Plant Leaves; Plants, Medicinal; Rats; Rats, Sprague-Dawley; Serotonin; Sleep | 2000 |
Electroshocks delay seizures and subsequent epileptogenesis but do not prevent neuronal damage in the lithium-pilocarpine model of epilepsy.
Topics: Animals; Anticonvulsants; Brain; Diazepam; Down-Regulation; Electrophysiology; Electroshock; Immunohistochemistry; Lithium; Male; Mossy Fibers, Hippocampal; Muscarinic Agonists; Neurons; Pilocarpine; Proto-Oncogene Proteins c-fos; Rats; Rats, Wistar; Seizures; Status Epilepticus | 2000 |
Seizure-induced neuronal necrosis: implications for programmed cell death mechanisms.
Topics: Animals; Apoptosis; Brain; Cell Nucleolus; Coloring Agents; DNA Damage; In Situ Nick-End Labeling; Kainic Acid; Lithium; Male; Necrosis; Neurons; Pilocarpine; Rats; Rats, Wistar; Status Epilepticus | 2000 |
A metabolic and neuropathological approach to the understanding of plastic changes that occur in the immature and adult rat brain during lithium-pilocarpine-induced epileptogenesis.
Topics: Age Factors; Animals; Brain; Female; Glucose; Lithium; Male; Nerve Degeneration; Neuronal Plasticity; Neurons; Pilocarpine; Rats; Rats, Sprague-Dawley; Status Epilepticus | 2000 |
Granule cell neurogenesis after status epilepticus in the immature rat brain.
Topics: Animals; Brain; Cell Division; Dentate Gyrus; Electric Stimulation; Hippocampus; Injections, Intraperitoneal; Lithium; Mossy Fibers, Hippocampal; Neuronal Plasticity; Perforant Pathway; Pilocarpine; Rats; Rats, Wistar; Status Epilepticus | 2000 |
The lesional and epileptogenic consequences of lithium-pilocarpine-induced status epilepticus are affected by previous exposure to isolated seizures: effects of amygdala kindling and maximal electroshocks.
Topics: Amygdala; Animals; Disease Models, Animal; Electroencephalography; Electroshock; Kindling, Neurologic; Lithium; Male; Muscarinic Agonists; Nerve Degeneration; Pilocarpine; Rats; Rats, Wistar; Seizures; Status Epilepticus | 2000 |
Temporal changes in neuronal dropout following inductions of lithium/pilocarpine seizures in the rat.
Topics: Animals; Brain; Cell Survival; Lithium; Male; Muscarinic Agonists; Neurons; Pilocarpine; Rats; Rats, Wistar; Seizures; Status Epilepticus | 2000 |
Effects of L-arginine on prevention and treatment of lithium-pilocarpine-induced status epilepticus.
Topics: Animals; Arginine; Cerebral Cortex; Disease Models, Animal; Dose-Response Relationship, Drug; Electroencephalography; Epilepsy, Temporal Lobe; Lithium; Male; Muscarinic Agonists; Nitric Oxide; Pilocarpine; Rats; Rats, Wistar; Seizures; Status Epilepticus; Survival Rate | 2000 |
Nonconvulsive status epilepticus in rats: impaired responsiveness to exteroceptive stimuli.
Topics: Animals; Behavior, Animal; Brain; Disease Models, Animal; Electroencephalography; Epilepsia Partialis Continua; Epilepsy, Complex Partial; Lithium; Male; Maze Learning; Motor Cortex; Muscarinic Agonists; Pilocarpine; Postural Balance; Random Allocation; Rats; Rats, Wistar; Social Behavior; Status Epilepticus | 2000 |
Relationship between neuronal loss and interictal glucose metabolism during the chronic phase of the lithium-pilocarpine model of epilepsy in the immature and adult rat.
Topics: Action Potentials; Age Factors; Animals; Behavior, Animal; Cell Count; Chronic Disease; Dentate Gyrus; Disease Models, Animal; Electroencephalography; Entorhinal Cortex; Epilepsy, Temporal Lobe; Glucose; Lithium; Male; Neurons; Pilocarpine; Prosencephalon; Rats; Rats, Sprague-Dawley; Seizures; Status Epilepticus; Thalamus | 2001 |
Lithium does not synergize the peripheral action of cholinomimetics as seen in the central nervous system.
Topics: Acetylcholine; Animals; Blood Pressure; Brain; Cholinergic Agents; Dose-Response Relationship, Drug; Drug Synergism; Female; Guinea Pigs; Ileum; Lithium; Male; Muscle Contraction; Muscle, Smooth; Peripheral Nerves; Pilocarpine; Rats; Rats, Wistar; Status Epilepticus | 2001 |
Repeated low-dose treatment of rats with pilocarpine: low mortality but high proportion of rats developing epilepsy.
Topics: Animals; Behavior, Animal; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Synergism; Epilepsy, Temporal Lobe; Female; Lithium; Muscarinic Agonists; Pilocarpine; Rats; Rats, Wistar; Status Epilepticus | 2001 |
Alterations of hippocampal GAbaergic system contribute to development of spontaneous recurrent seizures in the rat lithium-pilocarpine model of temporal lobe epilepsy.
Topics: Animals; Epilepsy, Temporal Lobe; gamma-Aminobutyric Acid; Hippocampus; Interneurons; Lithium; Neurons; Pilocarpine; Rats; Rats, Sprague-Dawley; Recurrence | 2001 |
Caspase inhibitors increase short-term survival of progenitor-cell progeny in the adult rat dentate gyrus following status epilepticus.
Topics: Animals; Antimetabolites; Bromodeoxyuridine; Caspase Inhibitors; Cell Count; Cell Survival; Convulsants; Dentate Gyrus; Enzyme Inhibitors; Glial Fibrillary Acidic Protein; Immunohistochemistry; In Situ Nick-End Labeling; Injections, Intraventricular; Lithium; Male; Pilocarpine; Rats; Rats, Sprague-Dawley; Status Epilepticus; Stem Cells; Tissue Fixation | 2001 |
Lithium-pilocarpine-induced status epilepticus in immature rats result in long-term deficits in spatial learning and hippocampal cell loss.
Topics: Aging; Animals; Disease Models, Animal; Epilepsy, Temporal Lobe; Female; Hippocampus; Lithium; Male; Maze Learning; Memory Disorders; Motor Activity; Movement Disorders; Muscarinic Agonists; Nerve Degeneration; Neurons; Pilocarpine; Rats; Rats, Sprague-Dawley; Status Epilepticus | 2001 |
Receptor reserve of phosphoinositide-coupled muscarinic receptors in mouse hippocampus in vivo.
Topics: Acetylcholine; Alzheimer Disease; Animals; Cholinergic Fibers; Dioxolanes; Dose-Response Relationship, Drug; Drug Interactions; Hippocampus; Hydrolysis; Lithium; Male; Mice; Muscarinic Agonists; Muscarinic Antagonists; Oxotremorine; Phosphatidylinositols; Pilocarpine; Pirenzepine; Receptors, Muscarinic; Synaptic Transmission | 2001 |
Weight gain in post-seized rats is facilitated by adding aspirin, glucose, or glucose-taurine-acetaminophen to food mush.
Topics: Acepromazine; Acetaminophen; Animals; Aspirin; Glucose; Hypothalamic Area, Lateral; Injections, Subcutaneous; Lithium; Male; Pilocarpine; Rats; Rats, Wistar; Status Epilepticus; Taurine; Weight Gain | 2001 |
Local cerebral blood flow during lithium-pilocarpine seizures in the developing and adult rat: role of coupling between blood flow and metabolism in the genesis of neuronal damage.
Topics: Aging; Animals; Animals, Newborn; Behavior, Animal; Brain; Cerebrovascular Circulation; Drug Synergism; Female; Glucose; Lithium; Male; Neurons; Pilocarpine; Rats; Rats, Sprague-Dawley; Seizures; Status Epilepticus | 2002 |
Immunohistochemical study of p53-associated proteins in rat brain following lithium-pilocarpine status epilepticus.
Topics: Animals; Ataxia Telangiectasia Mutated Proteins; bcl-2-Associated X Protein; Carbon-Oxygen Lyases; Cell Cycle Proteins; Cell Death; DNA-(Apurinic or Apyrimidinic Site) Lyase; DNA-Binding Proteins; fas Receptor; Immunohistochemistry; Lithium; Muscarinic Agonists; Nerve Degeneration; Neurons; Nuclear Proteins; Pilocarpine; Prosencephalon; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Proto-Oncogene Proteins c-mdm2; Rats; Rats, Wistar; Signal Transduction; Status Epilepticus; Tumor Suppressor Protein p53; Tumor Suppressor Proteins; Ubiquitin | 2002 |
Magnetic resonance imaging in the study of the lithium-pilocarpine model of temporal lobe epilepsy in adult rats.
Topics: Animals; Behavior, Animal; Brain; Cell Count; Epilepsy, Temporal Lobe; Glial Fibrillary Acidic Protein; Immunohistochemistry; Lithium; Magnetic Resonance Imaging; Male; Microtubule-Associated Proteins; Muscarinic Agonists; Neurons; Pilocarpine; Rats; Rats, Sprague-Dawley | 2002 |
Anticonvulsive activity of Butea monosperma flowers in laboratory animals.
Topics: Animals; Anticonvulsants; Behavior, Animal; Butea; Convulsants; Dyskinesia, Drug-Induced; Electroshock; Flowers; Lithium; Male; Pentylenetetrazole; Picrotoxin; Pilocarpine; Postural Balance; Rats; Rats, Sprague-Dawley; Seizures; Strychnine | 2002 |
Hydroethidine detection of superoxide production during the lithium-pilocarpine model of status epilepticus.
Topics: Animals; Brain; Ethidium; Lithium; Male; Phenanthridines; Pilocarpine; Rats; Rats, Wistar; Reactive Oxygen Species; Status Epilepticus; Superoxides | 2002 |
Epileptogenesis during development: injury, circuit recruitment, and plasticity.
Topics: Aging; Animals; Animals, Newborn; Convulsants; Dentate Gyrus; Electric Stimulation; Hippocampus; Immunohistochemistry; Lithium; Mossy Fibers, Hippocampal; Neural Inhibition; Neural Pathways; Neuronal Plasticity; Perforant Pathway; Phosphopyruvate Hydratase; Pilocarpine; Proto-Oncogene Proteins c-jun; Rats; Rats, Wistar; Recruitment, Neurophysiological; Status Epilepticus; Substance P | 2002 |
Status epilepticus induced by lithium-pilocarpine in the immature rat does not change the long-term susceptibility to seizures.
Topics: Aging; Animals; Animals, Newborn; Cerebellar Cortex; Disease Models, Animal; Disease Susceptibility; Dose-Response Relationship, Drug; Electroencephalography; Excitatory Amino Acid Agonists; Female; GABA Antagonists; GABA-A Receptor Antagonists; Kainic Acid; Lithium; Male; Muscarinic Agonists; Pentylenetetrazole; Picrotoxin; Pilocarpine; Rats; Rats, Sprague-Dawley; Reaction Time; Status Epilepticus | 2002 |
Effect of topiramate following recurrent and prolonged seizures during early development.
Topics: Animals; Animals, Newborn; Anticonvulsants; Body Weight; Cell Death; Cognition; Convulsants; Disease Models, Animal; Epilepsy; Flurothyl; Fructose; Hippocampus; Lithium; Maze Learning; Mossy Fibers, Hippocampal; Muscarinic Agonists; Nerve Degeneration; Pilocarpine; Rats; Rats, Sprague-Dawley; Reaction Time; Recurrence; Research Design; Topiramate | 2002 |
The brain matrix and multifocal brain damage following a single injection of ketamine in young adult rats: conspicuous changes in old age.
Topics: Acepromazine; Age Factors; Animals; Brain; Brain Damage, Chronic; Disease Models, Animal; Ketamine; Lithium; Male; Neurons; Pilocarpine; Rats; Rats, Wistar; Seizures | 2002 |
Detection of late epilepsy by the texture analysis of MR brain images in the lithium-pilocarpine rat model.
Topics: Animals; Cerebral Cortex; Entorhinal Cortex; Epilepsy; Image Processing, Computer-Assisted; Lithium; Magnetic Resonance Imaging; Male; Pilocarpine; Rats; Rats, Sprague-Dawley; Status Epilepticus | 2002 |
Epilepsy after early-life seizures can be independent of hippocampal injury.
Topics: Age Factors; Animals; Electroencephalography; Hippocampus; Lithium; Mossy Fibers, Hippocampal; Muscarinic Agonists; Pilocarpine; Rats; Rats, Sprague-Dawley; Status Epilepticus | 2003 |
Lithium/pilocarpine status epilepticus-induced neuropathology of piriform cortex and adjoining structures in rats is age-dependent.
Topics: Aging; Animals; Brain; Cerebral Cortex; Disease Susceptibility; Lithium; Pilocarpine; Rats; Status Epilepticus | 2003 |
Role of specific muscarinic receptor subtypes in cholinergic parasympathomimetic responses, in vivo phosphoinositide hydrolysis, and pilocarpine-induced seizure activity.
Topics: Animals; Apomorphine; Body Temperature; Cerebral Cortex; Dopamine Agonists; Dose-Response Relationship, Drug; Drug Interactions; Genotype; Hippocampus; Hydrolysis; Hypothermia; Lithium; Mice; Mice, Knockout; Muscarinic Agonists; Oxotremorine; Parasympathetic Nervous System; Phosphatidylinositols; Pilocarpine; Pupil; Receptors, Muscarinic; Salivation; Seizures | 2003 |
Estradiol reduces seizure-induced hippocampal injury in ovariectomized female but not in male rats.
Topics: Animals; Epilepsy; Estradiol; Female; Hippocampus; Lithium; Male; Muscarinic Agonists; Neurons; Neuroprotective Agents; Ovariectomy; Pilocarpine; Rats; Sex Characteristics | 2003 |
Chronic lithium treatment inhibits pilocarpine-induced mossy fiber sprouting in rat hippocampus.
Topics: Animals; Cell Count; Lithium; Male; Mossy Fibers, Hippocampal; Neural Inhibition; Pilocarpine; Rats; Rats, Wistar | 2003 |
Development of temporal lobe epilepsy in 21-day-old rats.
Topics: Age Factors; Animals; Brain; Disease Models, Animal; Epilepsy, Temporal Lobe; Lithium; Magnetic Resonance Imaging; Pilocarpine; Rats; Status Epilepticus | 2003 |
Long-term pregabalin treatment protects basal cortices and delays the occurrence of spontaneous seizures in the lithium-pilocarpine model in the rat.
Topics: Animals; Anticonvulsants; Astrocytes; Brain; Cell Death; Cerebral Cortex; Convulsants; Electroencephalography; Entorhinal Cortex; Epilepsy, Temporal Lobe; gamma-Aminobutyric Acid; Glial Fibrillary Acidic Protein; Hippocampus; Immunoenzyme Techniques; Lithium; Neuroprotective Agents; Parahippocampal Gyrus; Pilocarpine; Pregabalin; Rats; Rats, Sprague-Dawley; Status Epilepticus | 2003 |
Diazepam terminates brief but not prolonged seizures in young, naïve rats.
Topics: Age Factors; Animals; Anticonvulsants; Cerebral Cortex; Diazepam; Dose-Response Relationship, Drug; Drug Administration Schedule; Electroencephalography; Epilepsy, Generalized; Lithium; Male; Pilocarpine; Rats; Receptors, GABA-A; Status Epilepticus; Treatment Outcome | 2003 |
In the lithium-pilocarpine model of epilepsy, brain lesions are not linked to changes in blood-brain barrier permeability: an autoradiographic study in adult and developing rats.
Topics: Age Factors; Animals; Autoradiography; Behavior, Animal; Blood Volume; Blood-Brain Barrier; Brain; Disease Models, Animal; Epilepsy; Lithium; Male; Neurons; Permeability; Pilocarpine; Rats; Rats, Sprague-Dawley | 2003 |
Effect of the postictal state on visual-spatial memory in immature rats.
Topics: Animals; Animals, Newborn; Behavior, Animal; Caffeine; Central Nervous System Stimulants; Convulsants; Electroencephalography; Flurothyl; Hippocampus; Lithium; Male; Maze Learning; Memory; Memory Disorders; Muscarinic Agonists; Pilocarpine; Rats; Rats, Sprague-Dawley; Space Perception; Staining and Labeling; Status Epilepticus; Time Factors | 2003 |
Neuroprotective properties of topiramate in the lithium-pilocarpine model of epilepsy.
Topics: Animals; Blood Gas Analysis; Cell Death; Cerebral Cortex; Electroencephalography; Fructose; Hippocampus; Hydrogen-Ion Concentration; Lithium; Male; Neurons; Neuroprotective Agents; Pilocarpine; Rats; Rats, Sprague-Dawley; Status Epilepticus; Topiramate | 2004 |
Long-term effects of early-life malnutrition and status epilepticus: assessment by spatial navigation and CREB(Serine-133) phosphorylation.
Topics: Animals; Animals, Newborn; Cell Death; Cyclic AMP Response Element-Binding Protein; Down-Regulation; Epilepsy; Hippocampus; Humans; Infant Nutrition Disorders; Infant, Newborn; Lithium; Male; Maze Learning; Memory Disorders; Mortality; Neurons; Orientation; Phosphorylation; Pilocarpine; Rats; Rats, Sprague-Dawley; Signal Transduction; Space Perception; Status Epilepticus; Time | 2003 |
Detrimental effects of the ketogenic diet on cognitive function in rats.
Topics: Animals; Brain; Cognition; Diet; Lithium; Male; Maze Learning; Memory; Pilocarpine; Rats; Rats, Sprague-Dawley; Seizures | 2004 |
Pharmacological plasticity of GABA(A) receptors at dentate gyrus synapses in a rat model of temporal lobe epilepsy.
Topics: Animals; Anticonvulsants; Dentate Gyrus; Diazepam; Disease Models, Animal; Electric Conductivity; Epilepsy, Temporal Lobe; Flumazenil; GABA Modulators; Lithium; Male; Neural Inhibition; Patch-Clamp Techniques; Pilocarpine; Pregnanolone; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Status Epilepticus; Synapses | 2004 |
Emergence of spontaneous seizures during the year following lithium/pilocarpine-induced epilepsy and neuronal loss within the right temporal cortices.
Topics: Animals; Cell Survival; Epilepsy; Functional Laterality; Lithium; Male; Nerve Degeneration; Neurons; Pilocarpine; Rats; Rats, Wistar; Seizures; Temporal Lobe; Time Factors | 2004 |
Spontaneous recurrent seizure following status epilepticus enhances dentate gyrus neurogenesis.
Topics: Animals; Bromodeoxyuridine; Cell Differentiation; Cell Division; Dentate Gyrus; Disease Models, Animal; Lithium; Neuronal Plasticity; Neurons; Pilocarpine; Rats; Rats, Sprague-Dawley; Recurrence; Seizures; Status Epilepticus; Stem Cells | 2004 |
Differential neuroprotective effects of the NMDA receptor-associated glycine site partial agonists 1-aminocyclopropanecarboxylic acid (ACPC) and D-cycloserine in lithium-pilocarpine status epilepticus.
Topics: Amino Acids, Cyclic; Animals; Antimetabolites; Brain; Cycloserine; Electrodes, Implanted; Electroencephalography; Image Processing, Computer-Assisted; Lithium; Male; Motor Activity; Muscarinic Agonists; Neuroprotective Agents; Parasympathetic Nervous System; Pilocarpine; Rats; Rats, Sprague-Dawley; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate; Status Epilepticus | 2004 |
Postnatal maturation of cytochrome oxidase and lactate dehydrogenase activity and age-dependent consequences of lithium-pilocarpine status epilepticus in the rat: a regional histoenzymology study.
Topics: Age Factors; Animals; Animals, Newborn; Brain; Electron Transport Complex IV; Female; Glucose; L-Lactate Dehydrogenase; Lithium; Male; Muscarinic Agonists; Pilocarpine; Pregnancy; Rats; Rats, Sprague-Dawley; Status Epilepticus | 2004 |
Herbal treatment following post-seizure induction in rat by lithium pilocarpine: Scutellaria lateriflora (Skullcap), Gelsemium sempervirens (Gelsemium) and Datura stramonium (Jimson Weed) may prevent development of spontaneous seizures.
Topics: Administration, Oral; Animals; Anticonvulsants; Datura stramonium; Gelsemium; Lithium; Phytotherapy; Pilocarpine; Plant Extracts; Plants, Medicinal; Random Allocation; Rats; Rats, Wistar; Scutellaria; Seizures | 2004 |
Alpha2-adrenergic inhibition prevents the accompanied anticonvulsant effect of swim stress on behavioral convulsions induced by lithium and pilocarpine.
Topics: Adrenergic alpha-Antagonists; Animals; Anticonvulsants; Lithium; Male; Mifepristone; Naloxone; Pilocarpine; Rats; Rats, Wistar; Seizures; Stress, Physiological; Swimming; Yohimbine | 2004 |
Lipopolysaccharide-induced febrile convulsions in the rat: short-term sequelae.
Topics: Animals; Animals, Newborn; Body Temperature; Brain; Cell Death; Disease Models, Animal; Female; Fever; Humans; Immunohistochemistry; Kainic Acid; Lipopolysaccharides; Lithium; Pentylenetetrazole; Pilocarpine; Proto-Oncogene Proteins c-fos; Random Allocation; Rats; Rats, Sprague-Dawley; Seizures, Febrile | 2004 |
Lithium ion "cyclotron resonance" magnetic fields decrease seizure onset times in lithium-pilocarpine seized rats.
Topics: Analysis of Variance; Animals; Cyclotrons; Disease Models, Animal; Dose-Response Relationship, Drug; Dose-Response Relationship, Radiation; Electromagnetic Fields; Lithium; Lithium Chloride; Magnetic Resonance Spectroscopy; Male; Pilocarpine; Rats; Rats, Wistar; Seizures; Time Factors | 2004 |
In vivo 1H magnetic resonance spectroscopy, T2-weighted and diffusion-weighted MRI during lithium-pilocarpine-induced status epilepticus in the rat.
Topics: Animals; Brain; Diffusion Magnetic Resonance Imaging; Disease Models, Animal; Lithium; Male; Muscarinic Agonists; Pilocarpine; Rats; Rats, Wistar; Status Epilepticus | 2004 |
Temporal patterns of the cerebral inflammatory response in the rat lithium-pilocarpine model of temporal lobe epilepsy.
Topics: Animals; Cyclooxygenase 2; Disease Models, Animal; Epilepsy, Temporal Lobe; Inflammation; Interleukin-1; Kinetics; Lithium; NF-kappa B; Pilocarpine; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Sprague-Dawley; Status Epilepticus | 2004 |
Changes in phosphorylation of the NMDA receptor in the rat hippocampus induced by status epilepticus.
Topics: Animals; Cyclic AMP-Dependent Protein Kinases; Disease Models, Animal; Drug Synergism; Epilepsy; Focal Adhesion Kinase 2; Hippocampus; Lithium; Male; Muscarinic Agonists; Neurons; Phosphorylation; Pilocarpine; Protein Kinase C; Protein-Tyrosine Kinases; Rats; Rats, Long-Evans; Receptors, N-Methyl-D-Aspartate; Serine; src-Family Kinases; Status Epilepticus; Tyrosine | 2005 |
A 5-month period of epilepsy impairs spatial memory, decreases anxiety, but spares object recognition in the lithium-pilocarpine model in adult rats.
Topics: Animals; Anxiety; Behavior, Animal; Cell Count; Disease Models, Animal; Entorhinal Cortex; Epilepsy, Temporal Lobe; Exploratory Behavior; Hippocampus; Lithium; Maze Learning; Memory Disorders; Neurons; Parahippocampal Gyrus; Pilocarpine; Rats; Rats, Sprague-Dawley; Seizures; Spatial Behavior | 2005 |
Comparison of neuroprotective effects induced by alpha-phenyl-N-tert-butyl nitrone (PBN) and N-tert-butyl-alpha-(2 sulfophenyl) nitrone (S-PBN) in lithium-pilocarpine status epilepticus.
Topics: Animals; Benzenesulfonates; Brain; Cyclic N-Oxides; Disease Models, Animal; Electroencephalography; Free Radical Scavengers; Lithium; Male; Neuroprotective Agents; Nitrogen Oxides; Pilocarpine; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Status Epilepticus | 2005 |
Sucrose ingestion decreases seizure onset time in female rats treated with lithium and pilocarpine.
Topics: Animals; Disease Models, Animal; Female; Lithium; Male; Muscarinic Agonists; Pilocarpine; Rats; Seizures; Sex Factors; Sucrose; Sweetening Agents; Time Factors | 2005 |
Extreme obesity in female rats following prepuberal induction of lithium-pilocarpine seizures and a single injection of acepromazine.
Topics: Acepromazine; Animals; Body Weight; Chlorpromazine; Convulsants; Dopamine Antagonists; Female; Lithium; Male; Obesity; Organ Size; Pilocarpine; Rats; Seizures; Sex Characteristics; Sexual Maturation; Weight Gain | 2005 |
Effect of neonatal isolation on outcome following neonatal seizures in rats--the role of corticosterone.
Topics: Animals; Animals, Newborn; Behavior, Animal; Convulsants; Corticosterone; Cyclic AMP Response Element-Binding Protein; Enzyme Inhibitors; Hippocampus; Hypothalamo-Hypophyseal System; Kindling, Neurologic; Lithium; Male; Maternal Deprivation; Maze Learning; Metyrapone; Phosphorylation; Pilocarpine; Pituitary-Adrenal System; Random Allocation; Rats; Rats, Sprague-Dawley; Social Isolation; Spatial Behavior; Status Epilepticus | 2006 |
Increase in tyrosine phosphorylation of the NMDA receptor following the induction of status epilepticus.
Topics: Animals; Blotting, Western; Disease Models, Animal; Enzyme Activation; Focal Adhesion Kinase 2; Guanine Nucleotide Exchange Factors; Hippocampus; Lithium; Male; Phosphorylation; Pilocarpine; Rats; Rats, Long-Evans; Receptors, N-Methyl-D-Aspartate; src-Family Kinases; Status Epilepticus; Time Factors; Tyrosine | 2006 |
Effects of uridine in models of epileptogenesis and seizures.
Topics: Animals; Anticonvulsants; Behavior, Animal; Disease Models, Animal; Electroencephalography; Hippocampus; Kindling, Neurologic; Lithium; Male; Maze Learning; Pilocarpine; Rats; Rats, Sprague-Dawley; Status Epilepticus; Uridine; Water | 2006 |
Status epilepticus differentially alters AMPA and kainate receptor subunit expression in mature and immature dentate granule neurons.
Topics: Animals; Animals, Newborn; Blotting, Northern; Blotting, Western; Dentate Gyrus; Disease Models, Animal; Gene Expression Regulation, Developmental; Immunohistochemistry; Lithium; Neural Cell Adhesion Molecule L1; Neurons; Phosphopyruvate Hydratase; Pilocarpine; Protein Subunits; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, Kainic Acid; Reverse Transcriptase Polymerase Chain Reaction; Sialic Acids; Status Epilepticus | 2006 |
The combination of topiramate and diazepam is partially neuroprotective in the hippocampus but not antiepileptogenic in the lithium-pilocarpine model of temporal lobe epilepsy.
Topics: Animals; Anticonvulsants; Diazepam; Disease Models, Animal; Drug Therapy, Combination; Electroencephalography; Epilepsy, Temporal Lobe; Fructose; Hippocampus; Lithium; Magnetic Resonance Imaging; Male; Pilocarpine; Rats; Rats, Sprague-Dawley; Status Epilepticus; Topiramate | 2006 |
Increased GABA(A)-receptor alpha1-subunit expression in hippocampal dentate gyrus after early-life status epilepticus.
Topics: Animals; Animals, Newborn; Dentate Gyrus; Gene Expression; Hippocampus; Kainic Acid; Lithium; Nucleic Acid Amplification Techniques; Pilocarpine; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Status Epilepticus | 2006 |
Caspase-dependent programmed cell death pathways are not activated in generalized seizure-induced neuronal death.
Topics: Analysis of Variance; Animals; Caspase 8; Caspase 9; Cell Count; Cell Death; Disease Models, Animal; Enzyme Activation; Immunohistochemistry; In Situ Nick-End Labeling; Lithium; Male; Neurons; Pilocarpine; Rats; Rats, Wistar; Seizures | 2007 |
Dissociation of the immunoreactivity of synaptophysin and GAP-43 during the acute and latent phases of the lithium-pilocarpine model in the immature and adult rat.
Topics: Age Factors; Animals; Animals, Newborn; Behavior, Animal; Brain; Disease Models, Animal; GAP-43 Protein; Gene Expression Regulation, Developmental; Immunohistochemistry; Lithium; Male; Pilocarpine; Rats; Rats, Sprague-Dawley; Status Epilepticus; Synaptophysin; Time Factors | 2007 |
Proteome changes associated with hippocampal MRI abnormalities in the lithium pilocarpine-induced model of convulsive status epilepticus.
Topics: Animals; Disease Models, Animal; Electrophoresis, Gel, Two-Dimensional; Hippocampus; Humans; Lithium; Magnetic Resonance Imaging; Male; Mass Spectrometry; Muscarinic Agonists; Pilocarpine; Proteome; Rats; Rats, Sprague-Dawley; Status Epilepticus | 2007 |
Analysis of the extracellular matrix protein SC1 during reactive gliosis in the rat lithium-pilocarpine seizure model.
Topics: Animals; Astrocytes; Brain; Calcium-Binding Proteins; Disease Models, Animal; Extracellular Matrix Proteins; Glial Fibrillary Acidic Protein; Gliosis; Lithium; Male; Neurons; Phosphopyruvate Hydratase; Pilocarpine; Proliferating Cell Nuclear Antigen; Rats; Rats, Wistar; Seizures; Time Factors | 2007 |
Enhanced mortality of rat pups following inductions of epileptic seizures after perinatal exposures to 5 nT, 7 Hz magnetic fields.
Topics: Animals; Convulsants; Death, Sudden; Electromagnetic Fields; Female; Hippocampus; Lithium; Nitric Oxide Synthase Type III; Pilocarpine; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Wistar; Seizures | 2007 |
Pentoxifylline ameliorates lithium-pilocarpine induced status epilepticus in young rats.
Topics: Animals; Animals, Newborn; Behavior, Animal; Disease Models, Animal; Dopamine; Dose-Response Relationship, Drug; Female; Functional Laterality; Glutathione; Hippocampus; Lithium; Male; Maze Learning; Motor Activity; Neurons; Pentoxifylline; Phosphodiesterase Inhibitors; Pilocarpine; Rats; Rats, Sprague-Dawley; Rotarod Performance Test; Serotonin; Status Epilepticus; Thiobarbituric Acid Reactive Substances | 2008 |
Alterations of GABA A-receptor function and allosteric modulation during development of status epilepticus.
Topics: Allosteric Regulation; Animals; Anticonvulsants; Benzodiazepines; Diazepam; Disease Models, Animal; Hippocampus; In Vitro Techniques; Inhibitory Postsynaptic Potentials; Lithium; Male; Neurons; Patch-Clamp Techniques; Pilocarpine; Rats; Rats, Sprague-Dawley; Receptors, GABA; Status Epilepticus; Zinc | 2008 |
Activation of cerebral peroxisome proliferator-activated receptors gamma exerts neuroprotection by inhibiting oxidative stress following pilocarpine-induced status epilepticus.
Topics: Animals; Benzamides; Cell Death; Convulsants; Disease Models, Animal; Glutathione; Heme Oxygenase (Decyclizing); Hippocampus; Lipid Peroxidation; Lithium; Male; Muscarinic Agonists; Nerve Degeneration; Neuroprotective Agents; Oxidative Stress; Pilocarpine; PPAR gamma; Pyridines; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Rosiglitazone; Status Epilepticus; Superoxide Dismutase; Superoxide Dismutase-1; Thiazolidinediones | 2008 |
Programmed cell death in the lithium pilocarpine model: evidence for NMDA receptor and ceramide-mediated mechanisms.
Topics: Animals; Cell Death; Ceramides; Disease Models, Animal; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Female; Humans; In Situ Nick-End Labeling; Kainic Acid; Lithium; Male; Pilocarpine; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Seizures | 2008 |
Mu-calpain mediates hippocampal neuron death in rats after lithium-pilocarpine-induced status epilepticus.
Topics: Animals; Antipsychotic Agents; Apoptosis Inducing Factor; BH3 Interacting Domain Death Agonist Protein; Calpain; Cell Death; Cysteine Proteinase Inhibitors; Cytochromes c; Dipeptides; Hippocampus; Humans; Lithium; Male; Muscarinic Agonists; Neurons; Pilocarpine; Random Allocation; Rats; Rats, Wistar; Spectrin; Status Epilepticus | 2008 |
The extracellular matrix protein SC1/hevin localizes to excitatory synapses following status epilepticus in the rat lithium-pilocarpine seizure model.
Topics: Animals; Blotting, Western; Brain; Calcium-Binding Proteins; Extracellular Matrix Proteins; Image Processing, Computer-Assisted; Immunohistochemistry; Lithium; Microscopy, Confocal; Microscopy, Immunoelectron; Muscarinic Agonists; Pilocarpine; Rats; Seizures; Status Epilepticus; Synapses | 2008 |
Diabetic hyperglycemia aggravates seizures and status epilepticus-induced hippocampal damage.
Topics: Adenosine Triphosphate; Analysis of Variance; Animals; Biophysics; Blood Glucose; Brain Injuries; Computer Simulation; Diabetes Mellitus, Experimental; Electric Stimulation; Hippocampus; In Situ Nick-End Labeling; In Vitro Techniques; Lithium; Long-Term Potentiation; Male; Maze Learning; Models, Biological; Neurons; Pilocarpine; Rats; Rats, Sprague-Dawley; Seizures; Status Epilepticus | 2009 |
Differential expression of activating transcription factor-2 and c-Jun in the immature and adult rat hippocampus following lithium-pilocarpine induced status epilepticus.
Topics: Activating Transcription Factor 2; Animals; Antimanic Agents; Blotting, Western; Hippocampus; Immunohistochemistry; Lithium; Miotics; Pilocarpine; Proto-Oncogene Proteins c-jun; Rats; Status Epilepticus | 2009 |
Neurobehavioral maturation of offspring from epileptic dams: study in the rat lithium-pilocarpine model.
Topics: Age Factors; Animals; Animals, Newborn; Antipsychotic Agents; Behavior, Animal; Body Weight; Chi-Square Distribution; Disease Models, Animal; Epilepsy; Exploratory Behavior; Eyelids; Female; Lithium; Locomotion; Male; Maternal Exposure; Maze Learning; Muscarinic Agonists; Pilocarpine; Pregnancy; Prenatal Exposure Delayed Effects; Psychomotor Performance; Random Allocation; Rats; Rats, Sprague-Dawley; Reflex; Social Behavior | 2009 |
Drug transporters are altered in brain, liver and kidney of rats with chronic epilepsy induced by lithium-pilocarpine.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Brain; Choroid Plexus; Chronic Disease; Endothelial Cells; Epilepsy; Female; Kidney; Lithium; Liver; Male; Organic Anion Transporters; Pilocarpine; Rats; Rats, Wistar; RNA, Messenger; Status Epilepticus | 2010 |
Seizures increase cell proliferation in the dentate gyrus by shortening progenitor cell-cycle length.
Topics: Animals; Animals, Newborn; Cell Cycle; Cell Proliferation; Dentate Gyrus; Hippocampus; Humans; Immunohistochemistry; Lithium; Neurons; Pilocarpine; Status Epilepticus; Stem Cells | 2009 |
Vulnerability of postnatal hippocampal neurons to seizures varies regionally with their maturational stage.
Topics: Aging; Animals; Animals, Newborn; Antimanic Agents; Apoptosis; Apoptosis Regulatory Proteins; Calbindins; Caspase Inhibitors; Caspases; Cell Differentiation; Convulsants; Disease Models, Animal; Doublecortin Domain Proteins; Doublecortin Protein; Enzyme Inhibitors; Epilepsy; Female; Hippocampus; Lithium; Male; Microtubule-Associated Proteins; Nerve Degeneration; Neurogenesis; Neurons; Neuropeptides; Neuroprotective Agents; Pilocarpine; Rats; Rats, Wistar; S100 Calcium Binding Protein G | 2010 |
Remarkable increase in 14C-acetate uptake in an epilepsy model rat brain induced by lithium-pilocarpine.
Topics: Acetates; Acute Disease; Animals; Brain; Carbon Radioisotopes; Deoxyglucose; Disease Models, Animal; Epilepsy; Glucose; Iofetamine; Lithium; Male; Neuroglia; Pilocarpine; Rats; Rats, Wistar; Seizures; Time Factors | 2010 |
Molecular basis of self-sustaining seizures and pharmacoresistance during status epilepticus: The receptor trafficking hypothesis revisited.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Drug Resistance; Epilepsy; Hippocampus; Humans; Immunohistochemistry; Lithium; Models, Neurological; Pilocarpine; Rats; Receptors, GABA-A; Receptors, N-Methyl-D-Aspartate; Status Epilepticus; Synapses | 2009 |
Quantitative MRI predicts status epilepticus-induced hippocampal injury in the lithium-pilocarpine rat model.
Topics: Analysis of Variance; Animals; Brain Mapping; Cell Count; Cell Death; Cerebrovascular Circulation; Hippocampus; Image Processing, Computer-Assisted; Lithium; Magnetic Resonance Imaging; Male; Organ Size; Parietal Lobe; Pilocarpine; Predictive Value of Tests; Rats; Rats, Sprague-Dawley; Status Epilepticus; Thalamus; Time Factors | 2010 |
Nuclear translocation of mitochondrial cytochrome c, lysosomal cathepsins B and D, and three other death-promoting proteins within the first 60 minutes of generalized seizures.
Topics: Analysis of Variance; Animals; Apoptosis Inducing Factor; Apoptosis Regulatory Proteins; Cathepsin D; Cytochromes c; Deoxyribonucleases; Disease Models, Animal; Electroencephalography; Epilepsy, Generalized; Epoxy Compounds; Glycoside Hydrolases; Lithium; Lysosomes; Male; Mitochondria; Neurons; Pilocarpine; Protein Transport; Rats; Rats, Wistar; Tyrosine | 2010 |
Prevention of seizures and reorganization of hippocampal functions by transplantation of bone marrow cells in the acute phase of experimental epilepsy.
Topics: Analysis of Variance; Animals; Antigens, CD; Bone Marrow Transplantation; Cell Movement; Disease Models, Animal; Electric Stimulation; Excitatory Postsynaptic Potentials; Flow Cytometry; Glial Fibrillary Acidic Protein; Green Fluorescent Proteins; Hippocampus; In Vitro Techniques; Lithium; Long-Term Potentiation; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Neurons; Patch-Clamp Techniques; Pilocarpine; Rats; Rats, Wistar; Seizures; Status Epilepticus; Time Factors | 2010 |
Oxidative stress mediates hippocampal neuron death in rats after lithium-pilocarpine-induced status epilepticus.
Topics: Animals; Blotting, Western; Caspase 3; Cell Death; Hippocampus; Immunohistochemistry; Immunosuppressive Agents; Lithium; Male; Malondialdehyde; Neurons; Nitric Oxide; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type II; Oxidative Stress; Pilocarpine; Rats; Rats, Wistar; Status Epilepticus; Tacrolimus | 2010 |
Time-dependent changes in learning ability and induction of long-term potentiation in the lithium-pilocarpine-induced epileptic mouse model.
Topics: Animals; Biophysics; Conditioning, Classical; Disease Models, Animal; Electric Stimulation; Excitatory Postsynaptic Potentials; Fear; GABA Antagonists; Hippocampus; In Vitro Techniques; Learning Disabilities; Lithium; Long-Term Potentiation; Male; Mice; Mice, Inbred C57BL; Patch-Clamp Techniques; Picrotoxin; Pilocarpine; Status Epilepticus; Time Factors | 2010 |
Granulocyte colony-stimulating factor treatment prevents cognitive impairment following status epilepticus in rats.
Topics: Animals; Apoptosis; bcl-2-Associated X Protein; Caspase 3; Cognition Disorders; Granulocyte Colony-Stimulating Factor; Hippocampus; Humans; In Situ Nick-End Labeling; Lithium; Male; Maze Learning; Neuroprotective Agents; Phosphorylation; Pilocarpine; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-bcl-2; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Status Epilepticus | 2010 |
Effect of ketogenic diet on nucleotide hydrolysis and hepatic enzymes in blood serum of rats in a lithium-pilocarpine-induced status epilepticus.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Alkaline Phosphatase; Animals; Aspartate Aminotransferases; Convulsants; Diet, Ketogenic; Disease Models, Animal; Enzymes; Female; Hydrolysis; Lithium; Liver; Nucleotides; Pilocarpine; Rats; Rats, Wistar; Status Epilepticus | 2010 |
[Expression of IL-1 mRNA in the dentate gyrus of adult rats following lithium-pilocarione-induced seizures].
Topics: Animals; Dentate Gyrus; Disease Models, Animal; Humans; Interleukin 1 Receptor Antagonist Protein; Interleukin-1beta; Lithium; Male; Pilocarpine; Rats; Rats, Sprague-Dawley; Receptors, Interleukin-1; Seizures | 2010 |
Expression profile of microRNAs in rat hippocampus following lithium-pilocarpine-induced status epilepticus.
Topics: Animals; Convulsants; Gene Expression Profiling; Hippocampus; Lithium; Male; MicroRNAs; Oligonucleotide Array Sequence Analysis; Pilocarpine; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; Status Epilepticus | 2011 |
[Astrocytic gap junction in the hippocampus of rats with lithium pilocarpine-induced epilepsy].
Topics: Animals; Astrocytes; Connexin 43; Epilepsy; Gap Junctions; Glial Fibrillary Acidic Protein; Hippocampus; Lithium; Male; Neurons; Pilocarpine; Rats; Rats, Sprague-Dawley | 2010 |
Persistent impairment of mitochondrial and tissue redox status during lithium-pilocarpine-induced epileptogenesis.
Topics: Animals; Brain; Brain Chemistry; Disease Models, Animal; DNA, Mitochondrial; Energy Metabolism; Epilepsy, Temporal Lobe; Genomic Instability; Lithium; Male; Mitochondria; Oxidation-Reduction; Oxidative Stress; Pilocarpine; Rats; Rats, Sprague-Dawley; Time | 2010 |
Neuroprotective effects of recombinant human erythropoietin in the developing brain of rat after lithium-pilocarpine induced status epilepticus.
Topics: Animals; Apoptosis; Convulsants; Erythropoietin; Hippocampus; Humans; In Situ Nick-End Labeling; Lithium; Male; Neurons; Neuroprotective Agents; Pilocarpine; Rats; Rats, Wistar; Recombinant Proteins; Status Epilepticus | 2012 |
Bone marrow mononuclear cells reduce seizure frequency and improve cognitive outcome in chronic epileptic rats.
Topics: Animals; Bone Marrow Cells; Cell Transplantation; Chronic Disease; Cognition Disorders; Diazepam; Disease Models, Animal; Epilepsy; Lithium; Male; Maze Learning; Memory Disorders; Mice; Mice, Inbred C57BL; Monocytes; Pilocarpine; Rats; Rats, Wistar; Seizures; Swimming | 2011 |
An experimental study on dynamic morphological changes and expression pattern of GFAP and synapsin i in the hippocampus of MTLE models for immature rats.
Topics: Animals; Animals, Newborn; Cell Death; Disease Models, Animal; Epilepsy, Temporal Lobe; Gene Expression Regulation; Glial Fibrillary Acidic Protein; Hippocampus; Lithium; Neurons; Pilocarpine; Rats; Rats, Sprague-Dawley; Synapsins; Time Factors | 2011 |
Up-regulation of apelin in brain tissue of patients with epilepsy and an epileptic rat model.
Topics: Adolescent; Adult; Animals; Apelin; Blotting, Western; Brain; Case-Control Studies; Child; Disease Models, Animal; Epilepsy, Temporal Lobe; Female; Humans; Immunohistochemistry; Intercellular Signaling Peptides and Proteins; Lithium; Male; Neuroglia; Neurons; Pilocarpine; Rats; Rats, Sprague-Dawley; Up-Regulation; Young Adult | 2011 |
Change of presynaptic vesicle cycling in the hippocampus after status convulsion.
Topics: Age Factors; Animals; CA1 Region, Hippocampal; Female; Fluorescent Dyes; Humans; Lithium; Male; Neural Inhibition; Neuronal Plasticity; Pilocarpine; Pyridinium Compounds; Quaternary Ammonium Compounds; Rats; Rats, Wistar; Seizures; Synaptic Transmission; Synaptic Vesicles; Time Factors | 2012 |
Do proconvulsants modify or halt epileptogenesis? Pentylenetetrazole is ineffective in two rat models of temporal lobe epilepsy.
Topics: Animals; Convulsants; Disease Models, Animal; Epilepsy, Temporal Lobe; Female; GABA-A Receptor Agonists; Kainic Acid; Lithium; Pentylenetetrazole; Pilocarpine; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Seizures | 2012 |
Functional network changes in hippocampal CA1 after status epilepticus predict spatial memory deficits in rats.
Topics: Animals; CA1 Region, Hippocampal; Disease Models, Animal; Electrodes, Implanted; Entropy; Image Processing, Computer-Assisted; Lithium; Male; Maze Learning; Memory Disorders; Models, Neurological; Muscarinic Agonists; Nerve Net; Neurons; Pilocarpine; Predictive Value of Tests; Probability; Rats; Rats, Sprague-Dawley; Space Perception; Statistics as Topic; Statistics, Nonparametric; Status Epilepticus | 2012 |
TGFβ1 treatment reduces hippocampal damage, spontaneous recurrent seizures, and learning memory deficits in pilocarpine-treated rats.
Topics: Administration, Intranasal; Animals; Apoptosis; Hippocampus; Lithium; Male; Maze Learning; Memory Disorders; Pilocarpine; Rats; Rats, Sprague-Dawley; Status Epilepticus; Transforming Growth Factor beta1 | 2013 |
MicroRNA expression profile of the hippocampus in a rat model of temporal lobe epilepsy and miR-34a-targeted neuroprotection against hippocampal neurone cell apoptosis post-status epilepticus.
Topics: Analysis of Variance; Animals; Apoptosis; Caspase 3; Cell Death; Computational Biology; Disease Models, Animal; Epilepsy, Temporal Lobe; Hippocampus; In Situ Nick-End Labeling; Lithium; Male; Microarray Analysis; MicroRNAs; Neurons; Oligonucleotides; Pilocarpine; Rats; Rats, Sprague-Dawley; RNA, Messenger; Status Epilepticus; Up-Regulation | 2012 |
The inositol monophosphatase inhibitor L-690,330 affects pilocarpine-behavior and the forced swim test.
Topics: Animals; Antipsychotic Agents; Behavior, Animal; Diphosphonates; Injections, Intraventricular; Liposomes; Lithium; Male; Mice; Mice, Inbred ICR; Phosphoric Monoester Hydrolases; Pilocarpine; Seizures; Signal Transduction; Swimming | 2013 |
Post-seizure drug treatment in young rats determines clear incremental losses of frontal cortical and hippocampal neurons: the resultant damage is similar to very old brains.
Topics: Age Factors; Animals; Anticonvulsants; Case-Control Studies; Cell Count; Disease Models, Animal; Drug Administration Schedule; Female; Frontal Lobe; Hippocampus; Lithium; Neurons; Pilocarpine; Rats; Seizures | 2013 |
A comprehensive behavioral evaluation in the lithium-pilocarpine model in rats: effects of carisbamate administration during status epilepticus.
Topics: Animals; Anticonvulsants; Antipsychotic Agents; Behavior, Animal; Brain; Carbamates; Cell Count; Disease Models, Animal; Lithium; Male; Maze Learning; Memory; Mossy Fibers, Hippocampal; Muscarinic Agonists; Neurons; Phosphopyruvate Hydratase; Pilocarpine; Rats; Rats, Sprague-Dawley; Status Epilepticus; Visual Perception | 2013 |
Altered hippocampal myelinated fiber integrity in a lithium-pilocarpine model of temporal lobe epilepsy: a histopathological and stereological investigation.
Topics: Animals; Blotting, Western; Convulsants; Disease Models, Animal; Electroencephalography; Epilepsy, Temporal Lobe; Hippocampus; Immunohistochemistry; Lithium; Male; Microscopy, Electron, Transmission; Nerve Fibers, Myelinated; Pilocarpine; Rats; Rats, Sprague-Dawley | 2013 |
Neuronal degeneration is observed in multiple regions outside the hippocampus after lithium pilocarpine-induced status epilepticus in the immature rat.
Topics: Animals; Brain; Convulsants; Disease Models, Animal; Hippocampus; Lithium; Nerve Degeneration; Pilocarpine; Rats; Rats, Sprague-Dawley; Status Epilepticus | 2013 |
Pharmacological blockade of IL-1β/IL-1 receptor type 1 axis during epileptogenesis provides neuroprotection in two rat models of temporal lobe epilepsy.
Topics: Animals; Cell Death; Cerebral Cortex; Dipeptides; Disease Models, Animal; Electric Stimulation; Epilepsy, Temporal Lobe; Female; Glial Fibrillary Acidic Protein; Hippocampus; Humans; Interleukin 1 Receptor Antagonist Protein; Interleukin-1beta; Lithium; Male; para-Aminobenzoates; Pilocarpine; Rats; Rats, Sprague-Dawley; Receptors, Interleukin-1 Type I | 2013 |
Effect of lithium-pilocarpine-induced status epilepticus on ultrasonic vocalizations in the infant rat pup.
Topics: Age Factors; Animals; Animals, Newborn; Chi-Square Distribution; Convulsants; Disease Models, Animal; Female; Lithium; Male; Maternal Deprivation; Pilocarpine; Rats; Rats, Wistar; Status Epilepticus; Vocalization, Animal | 2014 |
Dexamethasone exacerbates cerebral edema and brain injury following lithium-pilocarpine induced status epilepticus.
Topics: Animals; Anti-Inflammatory Agents; Brain Edema; Brain Injuries; Cerebral Cortex; Dexamethasone; Disease Models, Animal; Image Processing, Computer-Assisted; Linear Models; Lithium; Magnetic Resonance Imaging; Male; Pilocarpine; Rats; Rats, Sprague-Dawley; Status Epilepticus; Time Factors | 2014 |
Melatonin protects testes against lithium-pilocarpine-induced temporal lobe epilepsy in rats: a time course study.
Topics: Animals; Apoptosis; Disease Models, Animal; Epilepsy, Temporal Lobe; Lithium; Male; Melatonin; Pilocarpine; Rats; Rats, Wistar; Sperm Motility; Spermatozoa; Testis | 2015 |
Dynamics of hippocampal acetylcholine release during lithium-pilocarpine-induced status epilepticus in rats.
Topics: Acetylcholine; Animals; Extracellular Fluid; Hippocampus; Lithium; Male; Pilocarpine; Rats; Rats, Sprague-Dawley; Status Epilepticus | 2014 |
Upregulated dynamin 1 in an acute seizure model and in epileptic patients.
Topics: Adolescent; Adult; Animals; Anticonvulsants; Brain Waves; Dynamin I; Epilepsy, Temporal Lobe; Female; Humans; Hydrazones; Lithium; Male; Pilocarpine; Rats; Rats, Sprague-Dawley; Reaction Time; Seizures; Up-Regulation | 2015 |
Persistent reduction of hippocampal glutamine synthetase expression after status epilepticus in immature rats.
Topics: Animals; Disease Models, Animal; gamma-Aminobutyric Acid; Glial Fibrillary Acidic Protein; Glutamate-Ammonia Ligase; Hippocampus; Immunohistochemistry; Lithium; Male; Neurons; Parvalbumins; Pilocarpine; Rats, Wistar; Seizures; Status Epilepticus; Vesicular Glutamate Transport Protein 1 | 2014 |
Ameliorating effects of proglumide on neurobehavioral and biochemical deficits in animal model of status epilepticus.
Topics: Animals; Cognition; Disease Models, Animal; Glutathione; Lithium; Male; Motor Activity; Oxidative Stress; Pilocarpine; Proglumide; Rats; Rats, Sprague-Dawley; Status Epilepticus | 2014 |
Bumetanide is not capable of terminating status epilepticus but enhances phenobarbital efficacy in different rat models.
Topics: Animals; Anticonvulsants; Basolateral Nuclear Complex; Bumetanide; Disease Models, Animal; Drug Synergism; Electric Stimulation; Kainic Acid; Lithium; Male; Phenobarbital; Pilocarpine; Rats; Rats, Sprague-Dawley; Status Epilepticus | 2015 |
Deep hypothermia for the treatment of refractory status epilepticus.
Topics: Animals; Convulsants; Drug Resistant Epilepsy; Electroencephalography; Hypothermia, Induced; Lithium; Male; Midazolam; Pilocarpine; Rats; Rats, Wistar; Status Epilepticus | 2015 |
Serotonin Depletion Does not Modify the Short-Term Brain Hypometabolism and Hippocampal Neurodegeneration Induced by the Lithium-Pilocarpine Model of Status Epilepticus in Rats.
Topics: Animals; Disease Models, Animal; Fenclonine; Gliosis; Hippocampus; Lithium; Magnetic Resonance Imaging; Male; Nerve Degeneration; Pilocarpine; Positron-Emission Tomography; Rats, Sprague-Dawley; Serotonin; Status Epilepticus; Time Factors | 2016 |
Bimodal Imaging of Inflammation with SPECT/CT and MRI Using Iodine-125 Labeled VCAM-1 Targeting Microparticle Conjugates.
Topics: Animals; Antibodies, Monoclonal; Brain; Contrast Media; Ferric Compounds; Image Processing, Computer-Assisted; Inflammation; Iodine Radioisotopes; Lithium; Magnetic Resonance Imaging; Male; Microspheres; Multimodal Imaging; Muscarinic Agonists; Pilocarpine; Radiopharmaceuticals; Rats; Rats, Sprague-Dawley; Status Epilepticus; Tissue Distribution; Tomography, Emission-Computed, Single-Photon; Tomography, X-Ray Computed; Vascular Cell Adhesion Molecule-1 | 2015 |
[Changes in CD40 expression in the pallium and hippocampus in epileptic rats].
Topics: Animals; CD40 Antigens; Epilepsy; Hippocampus; Immunohistochemistry; Lithium; Microglia; Pilocarpine; Rats; Rats, Sprague-Dawley; Status Epilepticus | 2015 |
Dock3 Participate in Epileptogenesis Through rac1 Pathway in Animal Models.
Topics: Action Potentials; Adolescent; Adult; Animals; Blotting, Western; Disease Models, Animal; Down-Regulation; Epilepsy; Excitatory Postsynaptic Potentials; Female; Green Fluorescent Proteins; Guanine Nucleotide Exchange Factors; Guanosine Triphosphate; Humans; Immunohistochemistry; Lithium; Male; Mice, Inbred C57BL; Mossy Fibers, Hippocampal; Nerve Tissue Proteins; Neurons; Pilocarpine; rac1 GTP-Binding Protein; Rats, Sprague-Dawley; RNA, Small Interfering; Signal Transduction; Young Adult | 2016 |
Early metabolic responses to lithium/pilocarpine-induced status epilepticus in rat brain.
Topics: Animals; Brain; Choline; Convulsants; Disease Models, Animal; Electrochemistry; Electron Transport Chain Complex Proteins; Glucose; Lactic Acid; Lithium; Male; Microdialysis; Oxidative Stress; Pilocarpine; Rats; Rats, Sprague-Dawley; Status Epilepticus | 2015 |
Novel combinations of phenotypic biomarkers predict development of epilepsy in the lithium-pilocarpine model of temporal lobe epilepsy in rats.
Topics: Animals; Biomarkers; Brain; Electroencephalography; Epilepsy, Temporal Lobe; Female; Lithium; Male; Pentylenetetrazole; Pilocarpine; Prospective Studies; Rats; Reaction Time; ROC Curve; Seizures; Status Epilepticus | 2015 |
The frequency of spontaneous seizures in rats correlates with alterations in sensorimotor gating, spatial working memory, and parvalbumin expression throughout limbic regions.
Topics: Animals; Behavior, Animal; Disease Models, Animal; Epilepsy, Temporal Lobe; Limbic System; Lithium; Male; Memory, Short-Term; Muscarinic Agonists; Parvalbumins; Pilocarpine; Prefrontal Cortex; Rats; Rats, Wistar; Seizures; Sensory Gating; Spatial Memory | 2016 |
Status epilepticus triggers early mitochondrial fusion in the rat hippocampus in a lithium-pilocarpine model.
Topics: Animals; Blotting, Western; Dynamins; GTP Phosphohydrolases; Hippocampus; Injections, Intraperitoneal; Lithium; Male; Membrane Proteins; Microscopy, Electron, Transmission; Mitochondria; Mitochondrial Dynamics; Mitochondrial Proteins; Models, Animal; Pilocarpine; Rats; Rats, Wistar; RNA, Messenger; Status Epilepticus; Time Factors | 2016 |
Pluronic P85-coated poly(butylcyanoacrylate) nanoparticles overcome phenytoin resistance in P-glycoprotein overexpressing rats with lithium-pilocarpine-induced chronic temporal lobe epilepsy.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Chronic Disease; Disease Models, Animal; Drug Resistance; Enbucrilate; Epilepsy, Temporal Lobe; Female; Hippocampus; Lithium; Nanoparticles; Phenytoin; Pilocarpine; Poloxalene; Rats, Sprague-Dawley; Reproducibility of Results; Seizures; Tissue Distribution | 2016 |
Hippocampal distribution of IL-1β and IL-1RI following lithium-pilocarpine-induced status epilepticus in the developing rat.
Topics: Animals; Convulsants; Disease Models, Animal; Hippocampus; Interleukin-1beta; Lithium; Pilocarpine; Rats; Receptors, Interleukin-1; RNA, Messenger; Status Epilepticus | 2016 |
Immediate and delayed treatment with gabapentin, carbamazepine and CNQX have almost similar impact on cognitive functions and behavior in the lithium-pilocarpine model in rats.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Amines; Animals; Behavior, Animal; Carbamazepine; Cognition; Cyclohexanecarboxylic Acids; Disease Models, Animal; Gabapentin; gamma-Aminobutyric Acid; Lithium; Male; Maze Learning; Motor Activity; Pilocarpine; Rats; Rats, Wistar; Status Epilepticus | 2016 |
Status epilepticus alters hippocampal long-term synaptic potentiation in a rat lithium-pilocarpine model.
Topics: 2-Amino-5-phosphonovalerate; Animals; Anticonvulsants; Convulsants; Disease Models, Animal; Hippocampus; In Vitro Techniques; Lithium; Long-Term Potentiation; Patch-Clamp Techniques; Pilocarpine; Rats; Rats, Wistar; Status Epilepticus; Time Factors | 2016 |
The effect of some immunomodulatory and anti-inflammatory drugs on Li-pilocarpine-induced epileptic disorders in Wistar rats.
Topics: Animals; Anti-Inflammatory Agents; Dinoprostone; Electroencephalography; Encephalitis; HSP72 Heat-Shock Proteins; Immunomodulation; Interleukin-1beta; Interleukin-6; Lithium; Male; Pilocarpine; Rats; Rats, Wistar; Status Epilepticus | 2016 |
Memantine attenuates cognitive impairments after status epilepticus induced in a lithium-pilocarpine model.
Topics: Animals; Cognition; Cognitive Dysfunction; Exploratory Behavior; Extinction, Psychological; Lithium; Male; Memantine; Orientation; Pilocarpine; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Spatial Memory; Status Epilepticus; Treatment Outcome | 2016 |
Intranasal Delivery of miR-146a Mimics Delayed Seizure Onset in the Lithium-Pilocarpine Mouse Model.
Topics: Administration, Intranasal; Animals; Behavior, Animal; Disease Models, Animal; Epilepsy, Temporal Lobe; Hippocampus; Inflammation; Lithium; Mice; Mice, Inbred C57BL; MicroRNAs; Pilocarpine; Seizures; Time Factors | 2017 |
Early morphological and functional changes in the GABAergic system of hippocampus in the rat lithium-pilocarpine model of epilepsy.
Topics: Animals; CA1 Region, Hippocampal; Disease Models, Animal; Epilepsy; GABA Plasma Membrane Transport Proteins; Glutamate Decarboxylase; Lithium; Male; Pilocarpine; Rats; Rats, Wistar | 2017 |
Phase-Dependent Astroglial Alterations in Li-Pilocarpine-Induced Status Epilepticus in Young Rats.
Topics: Animals; Astrocytes; Disease Models, Animal; Epilepsy, Temporal Lobe; Hippocampus; Lithium; Nerve Degeneration; Neurons; Pilocarpine; Rats, Wistar; Status Epilepticus | 2017 |
4,4'-Diisothiocyanatostilbene-2,2'-disulfonic acid attenuates spontaneous recurrent seizures and vasogenic edema following lithium-pilocarpine induced status epilepticus.
Topics: 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; Animals; Anticonvulsants; Apoptosis; Blood-Brain Barrier; Brain Edema; Disease Models, Animal; Epilepsy, Temporal Lobe; Lithium; Male; Pilocarpine; Rats, Sprague-Dawley; Status Epilepticus | 2017 |
Disease Modifying Effects of the Spider Toxin Parawixin2 in the Experimental Epilepsy Model.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Epilepsy, Temporal Lobe; Hippocampus; Lithium; Male; Neurons; Neuroprotective Agents; Neurotransmitter Uptake Inhibitors; Nipecotic Acids; Pilocarpine; Rats, Wistar; Spider Venoms; Tiagabine; Urea | 2017 |
The role of necroptosis in status epilepticus-induced brain injury in juvenile rats.
Topics: Amygdala; Animals; Biomarkers; Brain Injuries; Cognitive Dysfunction; Lithium; Male; Necrosis; Neurons; Pilocarpine; Piriform Cortex; Random Allocation; Rats; Rats, Sprague-Dawley; Status Epilepticus | 2017 |
Involvement of nitrergic system in anticonvulsant effect of zolpidem in lithium-pilocarpine induced status epilepticus: Evaluation of iNOS and COX-2 genes expression.
Topics: Animals; Anticonvulsants; Arginine; Cyclooxygenase 2; Dose-Response Relationship, Drug; Drug Interactions; Gene Expression Regulation, Enzymologic; Lithium; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase Type II; Pilocarpine; Pyridines; Rats; Rats, Wistar; Status Epilepticus; Zolpidem | 2017 |
Antagonist targeting microRNA-146a protects against lithium-pilocarpine-induced status epilepticus in rats by nuclear factor-κB pathway.
Topics: Animals; Biomarkers; Cytokines; Gene Expression; Hippocampus; Inflammation Mediators; Lithium; Male; MicroRNAs; NF-kappa B; Pilocarpine; Rats; Signal Transduction; Status Epilepticus | 2018 |
Intravenous infusion of mesenchymal stem cells reduces epileptogenesis in a rat model of status epilepticus.
Topics: Animals; Disease Models, Animal; Glutamate Decarboxylase; Green Fluorescent Proteins; Hippocampus; Infusions, Intravenous; Lithium; Magnetic Resonance Imaging; Male; Maze Learning; Mesenchymal Stem Cell Transplantation; Mesenchymal Stem Cells; Muscarinic Agonists; Neurons; Phosphopyruvate Hydratase; Pilocarpine; Rats; Rats, Sprague-Dawley; Rats, Transgenic; Status Epilepticus; Time Factors | 2018 |
Effects of dexamethasone on the Li-pilocarpine model of epilepsy: protection against hippocampal inflammation and astrogliosis.
Topics: Analysis of Variance; Animals; Anticonvulsants; Cytokines; Dexamethasone; Dinoprostone; Disease Models, Animal; Encephalitis; Epilepsy; Glial Fibrillary Acidic Protein; Gliosis; Glutamate-Ammonia Ligase; Glutathione; Hippocampus; In Vitro Techniques; L-Lactate Dehydrogenase; Lithium; Male; Pilocarpine; Rats; Rats, Wistar; S100 Calcium Binding Protein beta Subunit | 2018 |
Post-treatment with the GLP-1 analogue liraglutide alleviate chronic inflammation and mitochondrial stress induced by Status epilepticus.
Topics: Animals; Anti-Inflammatory Agents; bcl-2-Associated X Protein; Blood Glucose; Convulsants; Cytokines; Disease Models, Animal; Gene Expression Regulation; Hippocampus; Inflammation; Liraglutide; Lithium; Male; Mitochondria; Nerve Tissue Proteins; Pilocarpine; Proto-Oncogene Proteins c-bcl-2; Rats; Rats, Sprague-Dawley; Status Epilepticus; Time Factors | 2018 |
Folate homeostasis in epileptic rats.
Topics: Animals; Brain; CD11b Antigen; Convulsants; Disease Models, Animal; Folate Receptor 1; Folic Acid; Glial Fibrillary Acidic Protein; Hippocampus; Homeostasis; Lithium; Male; Phosphopyruvate Hydratase; Pilocarpine; Proton-Coupled Folate Transporter; Rats; Rats, Wistar; Reduced Folate Carrier Protein; RNA, Messenger; Statistics, Nonparametric; Status Epilepticus | 2018 |
Alterations in the Neurobehavioral Phenotype and ZnT3/CB-D28k Expression in the Cerebral Cortex Following Lithium-Pilocarpine-Induced Status Epilepticus: the Ameliorative Effect of Leptin.
Topics: Animals; Behavior, Animal; Cation Transport Proteins; Cerebral Cortex; Disease Models, Animal; Female; Gene Expression Regulation; Lithium; Male; Phenotype; Pilocarpine; Rats; Rats, Sprague-Dawley; Status Epilepticus | 2019 |
Immunotherapy by targeting of VGKC complex for seizure control and prevention of cognitive impairment in a mouse model of epilepsy.
Topics: Animals; Antibodies; Cognitive Dysfunction; Disease Models, Animal; Humans; Immunotherapy; Lithium; Mice; Pilocarpine; Potassium Channels, Voltage-Gated; Seizures | 2018 |
Inhibition of MyD88 Signaling Skews Microglia/Macrophage Polarization and Attenuates Neuronal Apoptosis in the Hippocampus After Status Epilepticus in Mice.
Topics: Animals; Apoptosis; Cell Polarity; Cytokines; Disease Models, Animal; Female; Gene Expression Regulation, Archaeal; Hippocampus; In Situ Nick-End Labeling; Lithium; Macrophages; Mice; Mice, Inbred C57BL; Mice, Transgenic; Microglia; Myeloid Differentiation Factor 88; Neurons; Peptides; Pilocarpine; Signal Transduction; Status Epilepticus; Toll-Like Receptor 4 | 2018 |
[CHANGES IN BRAIN ELECTRICAL ACTIVITY PATTERNS IN RATS WITH DIFFERENT SUSCEPTIBILITY TO SEIZURES IN LITHIUM-PILOCARPINE MODEL OF STATUS EPILEPTICUS].
Topics: Animals; Brain; Electroencephalography; Lithium; Male; Pilocarpine; Rats; Rats, Wistar; Status Epilepticus | 2016 |
Neuroprotective effects of levetiracetam, both alone and combined with propylparaben, in the long-term consequences induced by lithium-pilocarpine status epilepticus.
Topics: Animals; Anticonvulsants; Behavior, Animal; Disease Models, Animal; Hippocampus; Levetiracetam; Lithium; Male; Neurons; Neuroprotective Agents; Parabens; Pilocarpine; Rats, Wistar; Seizures; Status Epilepticus; Time | 2018 |
Inhibition of protease-activated receptor 1 ameliorates behavioral deficits and restores hippocampal synaptic plasticity in a rat model of status epilepticus.
Topics: Animals; Behavior, Animal; CA1 Region, Hippocampal; Disease Models, Animal; Epilepsy, Temporal Lobe; Lithium; Long-Term Potentiation; Male; Pilocarpine; Pyrroles; Quinazolines; Rats, Wistar; Receptor, PAR-1; Status Epilepticus | 2019 |
Glycyrrhizin, an HMGB1 inhibitor, exhibits neuroprotective effects in rats after lithium-pilocarpine-induced status epilepticus.
Topics: Animals; Apoptosis; Blood-Brain Barrier; Disease Models, Animal; Glycyrrhizic Acid; Hippocampus; HMGB1 Protein; Lithium; Male; Neurons; Neuroprotective Agents; Pilocarpine; Rats; Rats, Sprague-Dawley; Status Epilepticus | 2019 |
Intravenously Administered Ganaxolone Blocks Diazepam-Resistant Lithium-Pilocarpine-Induced Status Epilepticus in Rats: Comparison with Allopregnanolone.
Topics: Administration, Intravenous; Anesthetics; Animals; Anticonvulsants; Diazepam; Drug Resistant Epilepsy; Electroencephalography; Lithium; Male; Muscarinic Agonists; Pilocarpine; Pregnanolone; Rats; Rats, Sprague-Dawley; Status Epilepticus | 2019 |
The Effects of Minocycline on the Hippocampus in Lithium- Pilocarpine Induced Status Epilepticus in Rat: Relations with Microglial/Astrocytic Activation and Serum S100B Level.
Topics: Animals; Anti-Inflammatory Agents; Astrocytes; Biomarkers; Convulsants; Disease Models, Animal; Hippocampus; Lithium; Male; Microglia; Minocycline; Pilocarpine; Rats; Rats, Sprague-Dawley; S100 Calcium Binding Protein beta Subunit; Status Epilepticus | 2019 |
Aucubin Alleviates Seizures Activity in Li-Pilocarpine-Induced Epileptic Mice: Involvement of Inhibition of Neuroinflammation and Regulation of Neurotransmission.
Topics: Animals; Astrocytes; Disease Models, Animal; Epilepsy; Hippocampus; Iridoid Glucosides; Lithium; Male; Mice; Microglia; Pilocarpine; Seizures; Synaptic Transmission | 2019 |
The effects of lamotrigine and ethosuximide on seizure frequency, neuronal loss, and astrogliosis in a model of temporal-lobe epilepsy.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Electroencephalography; Epilepsy, Temporal Lobe; Ethosuximide; Female; Gliosis; Hippocampus; Lamotrigine; Lithium; Neurons; Neuroprotective Agents; Pilocarpine; Rats; Rats, Sprague-Dawley; Seizures; Status Epilepticus | 2019 |
(-)-Epigallocatechin-3-Gallate Protects Against Lithium-Pilocarpine-Induced Epilepsy by Inhibiting the Toll-Like Receptor 4 (TLR4)/Nuclear Factor-κB (NF-κB) Signaling Pathway.
Topics: Animals; Catechin; Disease Models, Animal; Epilepsy; Epilepsy, Temporal Lobe; Hippocampus; Lithium; Long-Term Potentiation; Male; Neurons; Neuroprotective Agents; NF-kappa B; Pilocarpine; Rats; Rats, Sprague-Dawley; Seizures; Signal Transduction; Toll-Like Receptor 4 | 2019 |
Intranasal Delivery of Botulinum Neurotoxin A Protects against Hippocampal Neuron Death in the Lithium-Pilocarpine Rat Model.
Topics: Administration, Intranasal; Animals; Botulinum Toxins, Type A; Cell Death; Hippocampus; Lithium; Male; Neurons; Neuroprotective Agents; Pilocarpine; Rats, Sprague-Dawley; Seizures | 2019 |
Hydrogen Alleviates Necroptosis and Cognitive Deficits in Lithium-Pilocarpine Model of Status Epilepticus.
Topics: Animals; Apoptosis; CA1 Region, Hippocampal; Cognition Disorders; Disease Models, Animal; Hydrogen; Inflammation; Lithium; Male; Memory; Necrosis; Neurons; Neuroprotective Agents; Pilocarpine; Rats, Sprague-Dawley; Spatial Learning; Status Epilepticus | 2019 |
Impairments in cognitive functions and emotional and social behaviors in a rat lithium-pilocarpine model of temporal lobe epilepsy.
Topics: Animals; Anxiety; Behavior, Animal; Cognition; Emotions; Epilepsy; Epilepsy, Temporal Lobe; Exploratory Behavior; Fear; Lithium; Male; Memory Disorders; Motor Activity; Pilocarpine; Rats; Rats, Wistar; Social Behavior; Spatial Memory; Status Epilepticus | 2019 |
Astrocytic BDNF and TrkB regulate severity and neuronal activity in mouse models of temporal lobe epilepsy.
Topics: Animals; Astrocytes; Brain-Derived Neurotrophic Factor; Disease Models, Animal; Epilepsy, Temporal Lobe; Gene Deletion; Hippocampus; Kainic Acid; Lithium; Locomotion; Mice, Inbred C57BL; Neurons; Neuroprotection; Phenotype; Pilocarpine; Receptor, trkB; Severity of Illness Index; Spatial Learning | 2020 |
The P2X7 receptor in activated microglia promotes depression- and anxiety-like behaviors in lithium -pilocarpine induced epileptic rats.
Topics: Animals; Anxiety; Depression; Lithium; Male; Microglia; Pilocarpine; Purinergic P2X Receptor Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Purinergic P2X7; Status Epilepticus | 2020 |
Rosiglitazone Prevents Autophagy by Regulating Nrf2-Antioxidant Response Element in a Rat Model of Lithium-pilocarpine-induced Status Epilepticus.
Topics: Animals; Antioxidant Response Elements; Autophagy; Lithium; Male; NF-E2-Related Factor 2; Oxidative Stress; Pilocarpine; Rats; Rats, Sprague-Dawley; Rosiglitazone; Status Epilepticus | 2021 |
Gastrodin alleviates seizure severity and neuronal excitotoxicities in the rat lithium-pilocarpine model of temporal lobe epilepsy via enhancing GABAergic transmission.
Topics: Animals; Anticonvulsants; Benzyl Alcohols; Disease Models, Animal; Electroencephalography; Epilepsy, Temporal Lobe; Gastrodia; Glucosides; Hippocampus; Lithium; Male; Medicine, Chinese Traditional; Neurons; Neuroprotective Agents; Pilocarpine; Rats, Sprague-Dawley; Receptors, GABA-A; Rhizome; Seizures; Status Epilepticus | 2021 |
Enriched environment ameliorates chronic temporal lobe epilepsy-induced behavioral hyperexcitability and restores synaptic plasticity in CA3-CA1 synapses in male Wistar rats.
Topics: Animals; CA1 Region, Hippocampal; CA3 Region, Hippocampal; Calbindins; Environment; Epilepsy, Temporal Lobe; Hyperkinesis; Lithium; Male; Neuronal Plasticity; Pilocarpine; Rats; Rats, Wistar; Status Epilepticus; Synapses; Synaptic Transmission; Synaptophysin | 2021 |
Citral Effects on the Expression Profile of
Topics: Acyclic Monoterpenes; Animals; Brain-Derived Neurotrophic Factor; Cytokines; Disease Models, Animal; Hippocampus; Lithium; Pilocarpine; Rats; Rats, Sprague-Dawley; Status Epilepticus | 2021 |
Cognitive Impairment and Mossy Fiber Sprouting in a Rat Model of Drug-resistant Epilepsy Induced by Lithium-pilocarpine.
Topics: Animals; Cognitive Dysfunction; Epilepsy; Humans; Lithium; Mossy Fibers, Hippocampal; Pilocarpine; Rats | 2021 |
Klotho ameliorated cognitive deficits in a temporal lobe epilepsy rat model by inhibiting ferroptosis.
Topics: Animals; Antioxidants; Cognitive Dysfunction; Convulsants; Epilepsy, Temporal Lobe; Ferroptosis; Genetic Therapy; Hippocampus; Iron Overload; Klotho Proteins; Lithium; Male; Neuroprotection; Pilocarpine; Rats; Rats, Sprague-Dawley | 2021 |
Inhibition of Glutamate Release, but Not of Glutamine Recycling to Glutamate, Is Involved in Delaying the Onset of Initial Lithium-Pilocarpine-Induced Seizures in Young Rats by a Non-Convulsive MSO Dose.
Topics: Animals; Brain; Disease Progression; Dose-Response Relationship, Drug; Glutamic Acid; Glutamine; Lithium; Male; Methionine Sulfoximine; Pilocarpine; Rats; Rats, Sprague-Dawley; Secretory Pathway; Seizures | 2021 |
Predicting signaling pathways regulating demyelination in a rat model of lithium-pilocarpine-induced acute epilepsy: A proteomics study.
Topics: Animals; Cell Differentiation; Demyelinating Diseases; Disease Models, Animal; Epilepsy; Hippocampus; Lithium; Male; MAP Kinase Signaling System; Myelin Sheath; p38 Mitogen-Activated Protein Kinases; Pilocarpine; Proteomics; Rats; Rats, Sprague-Dawley; Signal Transduction; Thymosin | 2021 |
Impairments of Long-Term Synaptic Plasticity in the Hippocampus of Young Rats during the Latent Phase of the Lithium-Pilocarpine Model of Temporal Lobe Epilepsy.
Topics: Animals; Disease Models, Animal; Epilepsy, Temporal Lobe; Hippocampus; Lithium; Long-Term Potentiation; Male; Pilocarpine; Rats; Rats, Wistar | 2021 |
MTEP, a Selective mGluR5 Antagonist, Had a Neuroprotective Effect but Did Not Prevent the Development of Spontaneous Recurrent Seizures and Behavioral Comorbidities in the Rat Lithium-Pilocarpine Model of Epilepsy.
Topics: Animals; Behavior, Animal; Disease Models, Animal; Epilepsy; Hippocampus; Lithium; Male; Neurons; Neuroprotective Agents; Pilocarpine; Pyridines; Rats; Rats, Wistar; Receptor, Metabotropic Glutamate 5; Seizures; Thiazoles | 2022 |
Changes in Metabotropic Glutamate Receptor Gene Expression in Rat Brain in a Lithium-Pilocarpine Model of Temporal Lobe Epilepsy.
Topics: Animals; Brain; Epilepsy; Epilepsy, Temporal Lobe; Gene Expression; Hippocampus; Humans; Lithium; Pilocarpine; Rats; RNA, Messenger | 2022 |
Modafinil exerts anticonvulsive effects against lithium-pilocarpine-induced status epilepticus in rats: A role for tumor necrosis factor-α and nitric oxide signaling.
Topics: Animals; Humans; Lithium; Modafinil; NG-Nitroarginine Methyl Ester; Nitric Oxide; Pilocarpine; Rats; Status Epilepticus; Tumor Necrosis Factor-alpha | 2022 |
Expression of matrix metalloproteinases and tissue inhibitors of metalloproteinases in the hippocampus of lithium-pilocarpine-induced acute epileptic rats.
Topics: Animals; Epilepsy; Hippocampus; Lithium; Matrix Metalloproteinases; Pilocarpine; Rats; Seizures; Tissue Inhibitor of Metalloproteinases | 2022 |
Pentylenetetrazole preconditioning attenuates severity of status epilepticus induced by lithium-pilocarpine in male rats: evaluation of opioid/NMDA receptors and nitric oxide pathway.
Topics: Analgesics, Opioid; Animals; Anticonvulsants; Enzyme Inhibitors; Lithium; Male; N-Methylaspartate; Nitric Oxide; Pentylenetetrazole; Pilocarpine; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Receptors, Opioid; Signal Transduction; Status Epilepticus | 2022 |
Spatio-Temporal Alterations in Synaptic Density During Epileptogenesis in the Rat Brain.
Topics: Animals; Brain; Epilepsy; Female; Hippocampus; Lithium; Membrane Glycoproteins; Nerve Tissue Proteins; Pilocarpine; Rats; Status Epilepticus | 2022 |
Multi-omic Analysis of the Gut Microbiome in Rats with Lithium-Pilocarpine-Induced Temporal Lobe Epilepsy.
Topics: Animals; Epilepsy; Epilepsy, Temporal Lobe; Gastrointestinal Microbiome; Lithium; Pilocarpine; Rats | 2022 |
Effect of morphine administration after status epilepticus on epileptogenesis in rats.
Topics: Animals; Disease Models, Animal; Epilepsy; Lithium; Morphine; Naloxone; Pilocarpine; Rats; Seizures; Status Epilepticus | 2022 |
Design and evaluation of chrysin-loaded nanoemulsion against lithium/pilocarpine-induced status epilepticus in rats; emphasis on formulation, neuronal excitotoxicity, oxidative stress, microglia polarization, and AMPK/SIRT-1/PGC-1α pathway.
Topics: AMP-Activated Protein Kinases; Animals; Epilepsy; Lithium; Microglia; Oxidative Stress; Pilocarpine; Rats; Status Epilepticus | 2023 |
PGC-1α Affects Epileptic Seizures by Regulating Mitochondrial Fusion in Epileptic Rats.
Topics: AMP-Activated Protein Kinases; Animals; Dimethyl Sulfoxide; Epilepsy; Lithium; Male; Mitochondrial Dynamics; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; Pilocarpine; Rats; Rats, Sprague-Dawley; Saline Solution; Seizures | 2023 |
The vasodilator naftidrofuryl attenuates short-term brain glucose hypometabolism in the lithium-pilocarpine rat model of status epilepticus without providing neuroprotection.
Topics: Animals; Brain; Disease Models, Animal; Glucose; Hippocampus; Humans; Lithium; Nafronyl; Neuroprotection; Pilocarpine; Rats; Seizures; Status Epilepticus; Vasodilator Agents | 2023 |
Protective effect of Nardostachys jatamansi extract against lithium-pilocarpine-induced spontaneous recurrent seizures and associated cardiac irregularities in a rat model.
Topics: Animals; Epilepsy; Lithium; Molecular Docking Simulation; Nardostachys; Pilocarpine; Rats; Seizures; Tandem Mass Spectrometry; TOR Serine-Threonine Kinases | 2023 |
Interictal aggression in rats with chronic seizures after an early life episode of status epilepticus.
Topics: Aggression; Animals; Epilepsy; Lithium; Male; Pilocarpine; Rats; Rats, Wistar; Seizures; Status Epilepticus | 2023 |
Thalidomide Attenuates Epileptogenesis and Seizures by Decreasing Brain Inflammation in Lithium Pilocarpine Rat Model.
Topics: Animals; Disease Models, Animal; Encephalitis; Epilepsy, Temporal Lobe; Hippocampus; Lithium; Male; Pilocarpine; Rats; Rats, Sprague-Dawley; Seizures; Status Epilepticus; Thalidomide; Tumor Necrosis Factor-alpha | 2023 |
Expression of Cytokines and Neurodegeneration in the Rat Hippocampus and Cortex in the Lithium-Pilocarpine Model of Status Epilepticus and the Role of Modulation of Endocannabinoid System.
Topics: Animals; Cytokines; Disease Models, Animal; Endocannabinoids; Hippocampus; Interleukin-6; Lithium; Neocortex; Neuroinflammatory Diseases; Pilocarpine; Rats; Status Epilepticus | 2023 |
Alterations in the Properties of the Rat Hippocampus Glutamatergic System in the Lithium-Pilocarpine Model of Temporal Lobe Epilepsy.
Topics: Animals; Disease Models, Animal; Epilepsy; Epilepsy, Temporal Lobe; Hippocampus; Lithium; Pilocarpine; Rats; Receptors, AMPA; Status Epilepticus | 2023 |
Phosphoglycerate kinase (PGK) 1 succinylation modulates epileptic seizures and the blood-brain barrier.
Topics: Adenosine Triphosphate; Angiostatins; Animals; Blood-Brain Barrier; Epilepsy; Lithium; Phosphoglycerate Kinase; Pilocarpine; Rats; Seizures; Vascular Endothelial Growth Factor A | 2023 |
A Single High Dose of Flufenamic Acid in Rats does not Reduce the Damage Associated with the Rat Lithium-Pilocarpine Model of Status Epilepticus but Leads to Deleterious Outcomes.
Topics: Animals; Anti-Inflammatory Agents; Disease Models, Animal; Epilepsy; Epilepsy, Temporal Lobe; Flufenamic Acid; Fluorodeoxyglucose F18; Gliosis; Glucose; Hippocampus; Lithium; Male; Neuroinflammatory Diseases; Pilocarpine; Rats; Rats, Sprague-Dawley; Status Epilepticus | 2023 |
Refinement of the Barnes and Morris water maze protocols improves characterization of spatial cognitive deficits in the lithium-pilocarpine rat model of epilepsy.
Topics: Animals; Cognition; Cognitive Dysfunction; Disease Models, Animal; Epilepsy; Epilepsy, Temporal Lobe; Lithium; Maze Learning; Morris Water Maze Test; Pilocarpine; Rats; Rats, Wistar; Spatial Learning | 2023 |
Dendritic reorganization in the hippocampus, anterior temporal lobe, and frontal neocortex of lithium-pilocarpine induced Status Epilepticus (SE).
Topics: Animals; Disease Models, Animal; Hippocampus; Lithium; Neocortex; Pilocarpine; Rats; Status Epilepticus; Temporal Lobe | 2023 |
Effect of U50488, a selective kappa opioid receptor agonist and levetiracetam against lithium-pilocarpine-induced status epilepticus, spontaneous convulsive seizures and related cognitive impairment.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Anticonvulsants; Disease Models, Animal; Levetiracetam; Lithium; Male; Pilocarpine; Rats; Rats, Wistar; Receptors, Opioid, kappa; Seizures; Status Epilepticus | 2023 |
The standardized extract of Centella asiatica L. Urb attenuates the convulsant effect induced by lithium/pilocarpine without affecting biochemical and haematological parameters in rats.
Topics: Animals; Anticonvulsants; Antioxidants; Centella; Chemical and Drug Induced Liver Injury; Convulsants; Lithium; Pilocarpine; Rats; Rats, Wistar; Seizures | 2023 |
Antiepileptogenic Effects of Anakinra, Lamotrigine and Their Combination in a Lithium-Pilocarpine Model of Temporal Lobe Epilepsy in Rats.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Epilepsy, Temporal Lobe; Hippocampus; Interleukin 1 Receptor Antagonist Protein; Lamotrigine; Lithium; Pilocarpine; Rats; Seizures | 2023 |