pilocarpine has been researched along with glutamic acid in 76 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (2.63) | 18.7374 |
| 1990's | 14 (18.42) | 18.2507 |
| 2000's | 25 (32.89) | 29.6817 |
| 2010's | 32 (42.11) | 24.3611 |
| 2020's | 3 (3.95) | 2.80 |
| Authors | Studies |
|---|---|
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Isokawa, M; Mello, LE | 1 |
| Berger, ML; Hornykiewicz, O; Hörtnagl, H; Reither, H | 1 |
| Funk, GD; Sholomenko, GN; Steeves, JD | 1 |
| Gunawan, S; Treiman, DM; Walton, NY | 1 |
| Carpenter, DO; ffrench-Mullen, JM; Hori, N; Nakanishi, H; Slater, NT | 1 |
| de Freitas, JC; Mendes, EG | 1 |
| Starr, BS; Starr, MS | 1 |
| Chapman, AG; Meldrum, BS; Millan, MH | 1 |
| Matsumoto, K; Murakami, Y; Watanabe, H | 1 |
| Ebinger, G; Michotte, Y; Smolders, I; Van Belle, K | 1 |
| Bogaert, L; Ebinger, G; Michotte, Y; Smolders, I | 1 |
| Dürmüller, N; Graham, JL; Meldrum, BS; Sowinski, P | 1 |
| Holmes, GL; Hori, A; Liu, Z; Sarkisian, MR; Stafstrom, CE; Tandon, P; Yang, Y | 1 |
| Ebinger, G; Khan, GM; Manil, J; Michotte, Y; Smolders, I | 1 |
| Ebinger, G; Khan, GM; Lindekens, H; Manil, J; Marvin, CA; Michotte, Y; Prikken, S; Smolders, I | 1 |
| French, SJ; Horner, CH; Humby, T; Rattray, M; Sofroniew, MV | 1 |
| Claudio, OI; Ferchmin, P; Moshé, SL; Ortiz, JG; Sperber, EF; Velísek, L | 1 |
| Ebinger, G; Khan, GM; Michotte, Y; Smolders, I | 2 |
| Bialer, M; Ebinger, G; Khan, GM; Lindekens, H; Michotte, Y; Smolders, I | 1 |
| DeLorenzo, RJ; Pal, S; Rafiq, A; Raza, M | 1 |
| Borrelli, E; Bozzi, Y | 1 |
| Clusmann, H; Dietrich, D; Erdmann, E; Kral, T; Schramm, J; Sochivko, D | 1 |
| Fong, JC; Hong, SJ; Wang, HZ; Wu, KY | 1 |
| Cavalheiro, EA; Costa, MS; Naffah-Mazzacoratti, Mda G; Perosa, SR; Rocha, JB | 1 |
| Clinckers, R; Ebinger, G; Lindekens, H; Lodge, D; Meurs, A; Michotte, Y; O'Neill, MJ; Smolders, I | 1 |
| Clinckers, R; Ebinger, G; Gheuens, S; Meurs, A; Michotte, Y; Smolders, I | 1 |
| Kullmann, DM; Schorge, S; Scimemi, A; Walker, MC | 1 |
| Jones, RS; Woodhall, GL; Yang, J | 1 |
| Clinckers, R; De Bundel, D; Ebinger, G; Meurs, A; Michotte, Y; Sarre, S; Smolders, I; Stragier, B | 1 |
| Becker, AJ; Flor, PJ; Gueler, N; Pitsch, J; Schoch, S; van der Putten, H | 1 |
| Assis, MA; Fonteles, MM; Freitas, RL; Freitas, RM; Pereira, MB; Silva, RF; Takahashi, RN | 1 |
| Carolino, RO; Coutinho-Netto, J; Cunha, AO; Dos Santos, WF; Mortari, MR | 1 |
| Clinckers, R; Ebinger, G; Meurs, A; Michotte, Y; Smolders, I | 1 |
| Khan, R; Krishnakumar, A; Paulose, CS | 1 |
| Bauer, B; Hartz, AM; Miller, DS; Pekcec, A; Potschka, H; Toellner, K | 1 |
| Chen, HZ; Cui, YY; Qi, H; Ren, QS; Wang, H; Zhou, W; Zhu, L; Zhu, X | 1 |
| Jesse, CR; Nogueira, CW; Rocha, JB; Savegnago, L | 1 |
| Bankstahl, JP; Bethmann, K; Hoffmann, K; Löscher, W | 1 |
| Aziz, MA; El Hay Ahmed, NA; Ibrahim, KM; Khadrawy, YA; Khedr, ME; Radwan, NM | 1 |
| Chen, GS; Huang, LT; Huang, YN; Lin, TC; Wang, JY | 1 |
| Bhaskaran, MD; Smith, BN | 1 |
| de Freitas, RM; de Oliveira Silva, F; Jordán, J; Saldanha, GB | 1 |
| Bavaresco, C; de Oliveira, DL; Fischer, A; Mussulini, BH; Souza, DO; Wofchuk, S; Wyse, AT | 1 |
| Campêlo, LM; Feitosa, CM; Freitas, RL; Freitas, RM; Saldanha, GB; Santos, PS | 1 |
| Raffa, RB; Rawls, SM; Song, K; Tallarida, C | 1 |
| Houser, CR; Wyeth, MS; Zhang, N | 1 |
| Balasubramaniam, A; Clinckers, R; Meurs, A; Michotte, Y; Portelli, J; Smolders, I | 1 |
| Bortolatto, CF; Gai, BM; Nogueira, CW; Roehrs, JA; Souza, AC; Wilhelm, EA | 1 |
| Coimbra, Rde C; Fernandes, MJ; Massironi, SG; Mazzacoratti, Mda G; Nehlig, A; Neto, EF; Persike, DS; Silva, IR; Vignoli, T | 1 |
| Ehlers, MD; Kunz, PA; Kwon, H; Mabb, AM; Peixoto, RT; Philpot, BD; Sabatini, BL | 1 |
| Hsuchou, H; Jayaram, B; Kastin, AJ; Khan, RS; Pan, W; Wu, X | 1 |
| Carobrez, AP; De Lima, TC; Duarte, FS; Duzzioni, M; Ern, AL; Gavioli, EC; Hoeller, AA; Lemos, T; Piermartiri, TC; Silva, NM; Tasca, CI | 1 |
| Loyens, E; Massie, A; Michotte, Y; Schallier, A; Smolders, I; Van Liefferinge, J; Vermoesen, K | 1 |
| Anju, TR; Antony, S; Jayanarayanan, S; Paulose, CS; Soman, S | 1 |
| Borges, K; Hadera, MG; McDonald, TS; Smeland, OB; Sonnewald, U | 1 |
| Angelo, MF; Lukin, J; Ramos, AJ; Rossi, AR; Villarreal, A | 1 |
| Chen, HZ; Cui, YY; Feng, XM; Li, H; Qiu, Y; Tan, PP; Yuan, HH; Zhou, W; Zhu, X | 1 |
| DeFranco, DB; Di Maio, R; Kanuparthi, PS; Samarasinghe, RA; Timothy Greenamyre, J | 1 |
| Orozco-Suárez, SA; Rocha, L; Santana-Gómez, CE; Valle-Dorado, MG | 1 |
| Amaral-Martins, F; Campos, AC; de Oliveira, AC; Fiebich, BL; Lima, IV; Miranda, AS; Moraes, MF; Santos, RP; Sousa, LP; Teixeira, AL; Teixeira, MM; Vago, JP; Vieira, ÉL; Vieira, LB | 1 |
| Alcántara-González, D; Bañuelos-Cabrera, I; Besio, W; Fernández-Mas, R; Luna-Munguía, H; Magdaleno-Madrigal, V; Rocha, L; Santana-Gómez, CE | 1 |
| Binaschi, A; Falcicchia, C; Palma, E; Roncon, P; Simonato, M; Soukupova, M; Zucchini, S | 1 |
| Guidine, PA; Medeiros, Dde C; Mello, LE; Moraes, MF; Moraes-Santos, T; Rezende, GH | 1 |
| Alcantara-Gonzalez, D; Banuelos-Cabrera, I; Besio, WG; Luna-Munguia, H; Magdaleno-Madrigal, V; Rocha, LL; Santana-Gomez, CE; Tamayo, M | 1 |
| Aseervatham, GS; Bose, PC; Sivasudha, T; Sundaram, S; Suryakala, U | 1 |
| Bruno-Blanch, L; Fernández-Mas, R; Magdaleno-Madrigal, VM; Orozco-Suárez, SA; Rocha, L; Santana-Gómez, CE; Talevi, A | 1 |
| Aarão, MC; Antonio, BB; Barros, V; Bittencourt, S; de Almeida, AG; Ferrazoli, E; Janisset, NRLL; Longo, BM; Macedo, CE; Mello, LE; Miranda, MF; Mundim, M; Porcionatto, M; Rodrigues, AM; Romariz, S; Valente, MF | 1 |
| Anas, ARJ; Eguchi, M; Oishi, K; Ono, K; Oya, M; Sawada, M; Suzuki, H; Yamaguchi, S | 1 |
| Fighera, MR; Freitas, ML; Funck, VR; Furian, AF; Larrick, JW; Mello, FK; Oliveira, CV; Oliveira, MS; Royes, LFF | 1 |
| Brandt, C; Klein, J; Löscher, W; Meller, S; Theilmann, W | 1 |
| Guo, F; Li, X; Liu, N; Ma, L; Sun, T; Yu, J; Zhang, X; Zheng, P; Zhou, R | 1 |
| Chen, Q; Chen, Y; Feng, Z; Huang, H; Peng, Y; Wang, J; Xu, Z; Zeng, J; Zhang, H; Zhang, J; Zhou, X | 1 |
| Acewicz, A; Albrecht, J; Czarnecka, AM; Czuczwar, SJ; Kołodziej, M; Obara-Michlewska, M; Pawlik, MJ; Popek, MP; Wierzba-Bobrowicz, T; Łuszczki, J | 1 |
| Albrecht, J; Aldana, BI; Belfiori-Carrasco, LF; Czarnecka, AM; Obara-Michlewska, M; Pawlik, MJ; Popek, MP | 1 |
76 other study(ies) available for pilocarpine and glutamic acid
| Article | Year |
|---|---|
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
NMDA receptor-mediated excitability in dendritically deformed dentate granule cells in pilocarpine-treated rats.
Topics: 2-Amino-5-phosphonovalerate; Animals; Dendrites; Epilepsy; Glutamates; Glutamic Acid; Hippocampus; In Vitro Techniques; Male; Membrane Potentials; Pilocarpine; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Synaptic Transmission | 1991 |
Cholinergic deficit induced by ethylcholine aziridinium (AF64A) in rat hippocampus: effect on glutamatergic systems.
Topics: Animals; Aziridines; Choline; Choline O-Acetyltransferase; Dizocilpine Maleate; Glutamates; Glutamic Acid; Hippocampus; Male; Neuromuscular Blocking Agents; Parasympathetic Nervous System; Pilocarpine; Rats; Rats, Inbred Strains; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Toxins, Biological | 1991 |
Avian locomotion activated by brainstem infusion of neurotransmitter agonists and antagonists. I. Acetylcholine excitatory amino acids and substance P.
Topics: Acetylcholine; Animals; Brain Stem; Carbachol; Choline O-Acetyltransferase; Diffusion; Ducks; Electric Stimulation; Geese; Glutamates; Glutamic Acid; Motor Activity; N-Methylaspartate; Pilocarpine; Reticular Formation; Substance P | 1991 |
Brain amino acid concentration changes during status epilepticus induced by lithium and pilocarpine.
Topics: Amino Acids; Animals; Aspartic Acid; Brain; Electroencephalography; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Glutamine; Lithium; Male; Pilocarpine; Rats; Rats, Inbred Strains; Status Epilepticus; Tissue Distribution | 1990 |
Asymmetric distribution of acetylcholine receptors and M channels on prepyriform neurons.
Topics: Acetylcholine; Action Potentials; Animals; Aspartic Acid; Brain Mapping; Calcium; Cerebral Cortex; Glutamates; Glutamic Acid; Homocysteine; Pilocarpine; Rats; Receptors, Cholinergic; Receptors, Muscarinic | 1983 |
The responses of isolated preparations of Bunodosoma caissarum (Correa, 1964) (Cnidaria, Anthozoa) to drugs.
Topics: Acetylcholine; Animals; Choline; Cnidaria; Epinephrine; Glutamates; Glutamic Acid; Hexamethonium Compounds; In Vitro Techniques; Muscle Contraction; Muscle, Smooth; Muscles; Norepinephrine; Pilocarpine; Quaternary Ammonium Compounds; Sea Anemones; Time Factors | 1984 |
Glutamate-dopamine interactions in the production of pilocarpine motor seizures in the mouse.
Topics: 2-Amino-5-phosphonovalerate; 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Dizocilpine Maleate; Dopamine Agents; Excitatory Amino Acid Antagonists; Glutamic Acid; Male; Mice; Mice, Inbred Strains; Pilocarpine; Piperazines; Pyrrolidinones; Quinoxalines; Receptors, AMPA; Receptors, Dopamine D1; Receptors, N-Methyl-D-Aspartate; Seizures | 1993 |
Extracellular amino acid levels in hippocampus during pilocarpine-induced seizures.
Topics: Amino Acids; Animals; Behavior, Animal; Dialysis; Dicarboxylic Acids; Epilepsy; Glutamates; Glutamic Acid; Hippocampus; Male; Neurotransmitter Uptake Inhibitors; Pilocarpine; Proline; Pyrrolidines; Rats; Rats, Sprague-Dawley | 1993 |
Effect of pilocarpine on striatal acetylcholine release in dopamine-depleted rats.
Topics: Acetylcholine; Animals; Corpus Striatum; Dopamine; gamma-Aminobutyric Acid; Glutamic Acid; Male; Microdialysis; Muscarinic Agonists; Pilocarpine; Rats; Rats, Wistar | 1997 |
Hippocampal and cerebellar extracellular amino acids during pilocarpine-induced seizures in freely moving rats.
Topics: Amino Acids; Animals; Aspartic Acid; Carbamazepine; Cerebellum; gamma-Aminobutyric Acid; Glutamic Acid; Hippocampus; Male; Microdialysis; Phenobarbital; Pilocarpine; Rats; Rats, Wistar; Seizures | 1997 |
Muscarinic modulation of striatal dopamine, glutamate, and GABA release, as measured with in vivo microdialysis.
Topics: Animals; Cholinergic Agents; Corpus Striatum; Diamines; Dopamine; gamma-Aminobutyric Acid; Glutamic Acid; Male; Microdialysis; Parasympatholytics; Parasympathomimetics; Pilocarpine; Pirenzepine; Rats; Rats, Wistar; Substantia Nigra | 1997 |
The vital dye Evans blue mimics limbic seizures induced by kainate or pilocarpine.
Topics: Animals; Behavior, Animal; Brain; Coloring Agents; Electroencephalography; Evans Blue; Excitatory Amino Acid Agonists; Extracellular Space; Glutamic Acid; Injections, Intraventricular; Kainic Acid; Limbic System; Male; Microdialysis; Pilocarpine; Rats; Rats, Wistar; Seizures | 1997 |
Seizure-induced glutamate release in mature and immature animals: an in vivo microdialysis study.
Topics: Aging; Animals; Brain Chemistry; Electroencephalography; Excitatory Amino Acid Agonists; Extracellular Space; Glutamic Acid; Kainic Acid; Male; Microdialysis; Muscarinic Agonists; Pilocarpine; Rats; Rats, Sprague-Dawley; Seizures | 1997 |
NMDA receptor-mediated pilocarpine-induced seizures: characterization in freely moving rats by microdialysis.
Topics: Animals; Anticonvulsants; Atropine; Convulsants; Dopamine; gamma-Aminobutyric Acid; Glutamic Acid; Hippocampus; Lamotrigine; Male; Microdialysis; Pilocarpine; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Seizures; Triazines | 1997 |
Effectiveness of vigabatrin against focally evoked pilocarpine-induced seizures and concomitant changes in extracellular hippocampal and cerebellar glutamate, gamma-aminobutyric acid and dopamine levels, a microdialysis-electrocorticography study in freel
Topics: Animals; Anticonvulsants; Cerebellum; Dopamine; Electroencephalography; gamma-Aminobutyric Acid; Glutamic Acid; Hippocampus; Male; Microdialysis; Pilocarpine; Rats; Rats, Wistar; Substantia Nigra; Vigabatrin | 1997 |
Hippocampal neurotrophin and trk receptor mRNA levels are altered by local administration of nicotine, carbachol and pilocarpine.
Topics: Acetylcholine; Animals; Behavior, Animal; Brain Chemistry; Brain-Derived Neurotrophic Factor; Carbachol; Cell Death; Cholinergic Agonists; Cholinergic Fibers; Epilepsy; Gene Expression; Glutamic Acid; Hippocampus; In Situ Hybridization; Male; Muscarinic Agonists; Nerve Growth Factors; Neuroprotective Agents; Neurotrophin 3; Nicotine; Nicotinic Agonists; Pilocarpine; Proto-Oncogene Proteins; Rats; Rats, Sprague-Dawley; Receptor Protein-Tyrosine Kinases; Receptor, Ciliary Neurotrophic Factor; Receptor, Nerve Growth Factor; Receptor, trkA; Receptor, trkC; Receptors, Nerve Growth Factor; RNA, Messenger; Septal Nuclei; Synaptic Transmission | 1999 |
Plasticity of excitatory amino acid transporters in experimental epilepsy.
Topics: Animals; Dicarboxylic Acids; Epilepsy; Female; Glutamic Acid; Hippocampus; Kainic Acid; Magnesium; Neuronal Plasticity; Neurotransmitter Uptake Inhibitors; Pilocarpine; Propionates; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Glutamate; Receptors, Metabotropic Glutamate; Up-Regulation; Veratridine | 2000 |
Flumazenil prevents diazepam-elicited anticonvulsant action and concomitant attenuation of glutamate overflow.
Topics: Animals; Anticonvulsants; Convulsants; Diazepam; Flumazenil; GABA Modulators; Glutamic Acid; Male; Pilocarpine; Rats; Rats, Wistar; Receptors, GABA-A; Seizures | 2000 |
In vivo study of the effect of valpromide and valnoctamide in the pilocarpine rat model of focal epilepsy.
Topics: Amides; Animals; Anti-Anxiety Agents; Anticonvulsants; Epilepsies, Partial; gamma-Aminobutyric Acid; Glutamic Acid; Hippocampus; Male; Microdialysis; Muscarinic Agonists; Pilocarpine; Rats; Rats, Wistar; Valproic Acid | 2000 |
2-chloro-N(6)-cyclopentyladenosine-elicited attenuation of evoked glutamate release is not sufficient to give complete protection against pilocarpine-induced seizures in rats.
Topics: Adenosine; Animals; Behavior, Animal; Dopamine; Electroencephalography; Electrophysiology; gamma-Aminobutyric Acid; Glutamic Acid; Hippocampus; Indicators and Reagents; Male; Neurotransmitter Agents; Pilocarpine; Rats; Rats, Wistar; Seizures; Xanthines | 2001 |
Long-term alteration of calcium homeostatic mechanisms in the pilocarpine model of temporal lobe epilepsy.
Topics: Animals; Calcium; Cell Survival; Disease Models, Animal; Epilepsy, Temporal Lobe; Fluorescent Dyes; Fura-2; Glutamic Acid; Hippocampus; Homeostasis; Male; Microscopy, Fluorescence; Muscarinic Agonists; Neuronal Plasticity; Pilocarpine; Rats; Status Epilepticus; Time Factors | 2001 |
Dopamine D2 receptor signaling controls neuronal cell death induced by muscarinic and glutamatergic drugs.
Topics: Acetylcholine; Animals; Behavior, Animal; Cell Death; Dose-Response Relationship, Drug; Epilepsy; Excitatory Amino Acid Agonists; Female; Genotype; Glutamic Acid; Kainic Acid; Limbic System; Male; Mice; Mice, Knockout; Molecular Sequence Data; Muscarinic Agonists; Nerve Degeneration; Pilocarpine; Receptors, Dopamine D2; Receptors, Muscarinic; RNA, Messenger; Signal Transduction; Synaptic Transmission | 2002 |
Down-regulation of mGluR8 in pilocarpine epileptic rats.
Topics: Animals; Down-Regulation; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Glutamic Acid; Hippocampus; Immunohistochemistry; Male; Muscarinic Agonists; Organ Culture Techniques; Perforant Pathway; Pilocarpine; Rats; Rats, Wistar; Receptors, Metabotropic Glutamate; Status Epilepticus; Synapses | 2003 |
Effects of commercial antiglaucoma drugs to glutamate-induced [Ca2+)]i increase in cultured neuroblastoma cells.
Topics: Animals; Antihypertensive Agents; Betaxolol; Brimonidine Tartrate; Calcium; Carteolol; Cell Death; Dose-Response Relationship, Drug; Epinephrine; Glaucoma; Glutamic Acid; Latanoprost; Mice; Neuroblastoma; Neurons; Neuroprotective Agents; Pilocarpine; Prostaglandins F, Synthetic; Quinoxalines; Sulfonamides; Thiazines; Thiophenes; Timolol; Tumor Cells, Cultured | 2003 |
Pilocarpine-induced status epilepticus increases glutamate release in rat hippocampal synaptosomes.
Topics: Animals; Glutamic Acid; Hippocampus; Male; Pilocarpine; Rats; Rats, Wistar; Status Epilepticus; Synaptosomes | 2004 |
In vivo modulation of extracellular hippocampal glutamate and GABA levels and limbic seizures by group I and II metabotropic glutamate receptor ligands.
Topics: Amino Acids; Animals; Anticonvulsants; Benzoates; Bridged Bicyclo Compounds, Heterocyclic; Cyclopropanes; Disease Models, Animal; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Extracellular Fluid; gamma-Aminobutyric Acid; Glutamic Acid; Glycine; Hippocampus; Ligands; Limbic System; Male; Microdialysis; Pilocarpine; Pyridines; Rats; Rats, Wistar; Receptors, Metabotropic Glutamate; Seizures | 2004 |
In vivo modulatory action of extracellular glutamate on the anticonvulsant effects of hippocampal dopamine and serotonin.
Topics: Animals; Anticonvulsants; Convulsants; Dopamine; Dopamine Antagonists; Epilepsy; Glutamic Acid; Hippocampus; Limbic System; Male; Microdialysis; Pilocarpine; Rats; Rats, Wistar; Receptors, Dopamine; Receptors, Serotonin; Serotonin | 2005 |
Epileptogenesis is associated with enhanced glutamatergic transmission in the perforant path.
Topics: Animals; Disease Models, Animal; Epilepsy, Temporal Lobe; Glutamic Acid; Hippocampus; Long-Term Potentiation; Male; Neuronal Plasticity; Neurons; Neurotransmitter Agents; Perforant Pathway; Pilocarpine; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Synaptic Transmission | 2006 |
Tonic facilitation of glutamate release by presynaptic NR2B-containing NMDA receptors is increased in the entorhinal cortex of chronically epileptic rats.
Topics: Age Factors; Animals; Autoreceptors; Chronic Disease; Entorhinal Cortex; Epilepsy, Generalized; Excitatory Amino Acid Antagonists; Glutamic Acid; Male; Membrane Potentials; Neurons; Patch-Clamp Techniques; Phenols; Pilocarpine; Piperidines; Quinoxalines; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Status Epilepticus | 2006 |
Involvement of the somatostatin-2 receptor in the anti-convulsant effect of angiotensin IV against pilocarpine-induced limbic seizures in rats.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Anticonvulsants; Benzimidazoles; Biphenyl Compounds; Dopamine; Glutamic Acid; Hippocampus; Injections, Intraventricular; Limbic System; Male; Microdialysis; Oligopeptides; Pilocarpine; Rats; Rats, Wistar; Receptors, Somatostatin; Seizures; Serotonin; Somatostatin; Tetrazoles | 2006 |
Functional role of mGluR1 and mGluR4 in pilocarpine-induced temporal lobe epilepsy.
Topics: Animals; Convulsants; Disease Models, Animal; Down-Regulation; Epilepsy; Epilepsy, Temporal Lobe; Gene Expression Regulation; Genetic Predisposition to Disease; Glutamic Acid; Green Fluorescent Proteins; Hippocampus; Mice; Mice, Knockout; Mice, Transgenic; Nerve Degeneration; Neurons; Pilocarpine; Receptors, Metabotropic Glutamate; Recombinant Fusion Proteins; Up-Regulation | 2007 |
Study pharmacologic of the GABAergic and glutamatergic drugs on seizures and status epilepticus induced by pilocarpine in adult Wistar rats.
Topics: Amines; Animals; Anticonvulsants; Cyclohexanecarboxylic Acids; Excitatory Amino Acid Antagonists; Gabapentin; gamma-Aminobutyric Acid; Glutamic Acid; Glutamine; Ketamine; Male; Muscarinic Agonists; N-Methylaspartate; Phenobarbital; Pilocarpine; Rats; Rats, Wistar; Receptors, GABA; Receptors, Neurotransmitter; Seizures; Status Epilepticus; Vigabatrin | 2007 |
Glutamate binding is altered in hippocampus and cortex of Wistar rats after pilocarpine-induced Status Epilepticus.
Topics: Animals; Binding Sites; Cerebral Cortex; Convulsants; Epilepsy; Glutamic Acid; Hippocampus; Ligands; Male; Neuronal Plasticity; Pilocarpine; Rats; Rats, Wistar; Receptors, Glutamate; Status Epilepticus; Synaptic Transmission | 2007 |
Seizure activity and changes in hippocampal extracellular glutamate, GABA, dopamine and serotonin.
Topics: Analysis of Variance; Animals; Behavior, Animal; Chromatography, Liquid; Disease Models, Animal; Dopamine; Electroencephalography; Extracellular Fluid; gamma-Aminobutyric Acid; Glutamic Acid; Hippocampus; Male; Methoxyhydroxyphenylglycol; Microdialysis; Picrotoxin; Pilocarpine; Rats; Rats, Wistar; Seizures; Serotonin; Statistics, Nonparametric; Time Factors | 2008 |
Decreased glutamate receptor binding and NMDA R1 gene expression in hippocampus of pilocarpine-induced epileptic rats: neuroprotective role of Bacopa monnieri extract.
Topics: Analysis of Variance; Animals; Bacopa; Behavior, Animal; Disease Models, Animal; Dose-Response Relationship, Drug; Epilepsy; Gene Expression Regulation; Glutamate Dehydrogenase; Glutamic Acid; Hippocampus; Male; Maze Learning; Phytotherapy; Pilocarpine; Plant Preparations; Protein Binding; Rats; Rats, Wistar; Reaction Time; Receptors, N-Methyl-D-Aspartate | 2008 |
Seizure-induced up-regulation of P-glycoprotein at the blood-brain barrier through glutamate and cyclooxygenase-2 signaling.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Blood-Brain Barrier; Capillaries; Cyclooxygenase 2; Female; Glutamic Acid; Hippocampus; Indomethacin; Male; Mice; Mice, Inbred C57BL; Pilocarpine; Protein Biosynthesis; Rats; Rats, Sprague-Dawley; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Seizures; Signal Transduction; Transcription, Genetic; Up-Regulation | 2008 |
Neuroprotection of muscarinic receptor agonist pilocarpine against glutamate-induced apoptosis in retinal neurons.
Topics: Animals; Apoptosis; Calcium; Caspase 3; Cell Survival; Cells, Cultured; Gene Expression; Glaucoma; Glutamic Acid; Homeostasis; Membrane Potential, Mitochondrial; Muscarinic Agonists; Neuroprotective Agents; Pilocarpine; Proto-Oncogene Proteins c-bcl-2; Rats; Rats, Sprague-Dawley; Retinal Ganglion Cells | 2008 |
Neuroprotective effect caused by MPEP, an antagonist of metabotropic glutamate receptor mGluR5, on seizures induced by pilocarpine in 21-day-old rats.
Topics: Acetylcholinesterase; Animals; Brain; Convulsants; Cytoprotection; Disease Models, Animal; Dose-Response Relationship, Drug; Epilepsy; Excitatory Amino Acid Antagonists; Glutamic Acid; Male; Muscarinic Agonists; Nerve Degeneration; Neuroprotective Agents; Oxidative Stress; Pilocarpine; Pyridines; Rats; Rats, Wistar; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate; Synaptic Transmission; Treatment Outcome | 2008 |
Glutamate is critically involved in seizure-induced overexpression of P-glycoprotein in the brain.
Topics: Animals; Apoptosis; ATP Binding Cassette Transporter, Subfamily B, Member 1; Brain Chemistry; Capillaries; Dizocilpine Maleate; Epilepsy, Temporal Lobe; Excitatory Amino Acid Antagonists; Female; Glutamic Acid; Image Processing, Computer-Assisted; Immunohistochemistry; Muscarinic Agonists; Nerve Degeneration; Pilocarpine; Quinolines; Rats; Rats, Wistar; Seizures; Status Epilepticus | 2008 |
Effect of infrared laser irradiation on amino acid neurotransmitters in an epileptic animal model induced by pilocarpine.
Topics: Alanine Transaminase; Amino Acids; Analysis of Variance; Animals; Aspartate Aminotransferases; Aspartic Acid; Cerebral Cortex; Chromatography, High Pressure Liquid; Epilepsy; gamma-Aminobutyric Acid; Glutamic Acid; Glycine; Hippocampus; Lasers, Semiconductor; Male; Models, Animal; Neurotransmitter Agents; Pilocarpine; Rats; Taurine | 2009 |
Neonatal status epilepticus alters prefrontal-striatal circuitry and enhances methamphetamine-induced behavioral sensitization in adolescence.
Topics: Age Factors; Animals; Animals, Newborn; Behavior, Animal; Corpus Striatum; Disease Models, Animal; Dopamine; Dopamine Agents; Female; Gene Expression Regulation, Developmental; Glutamic Acid; Lithium Compounds; Male; Methamphetamine; Motor Activity; Neural Pathways; Pilocarpine; Prefrontal Cortex; Pregnancy; Rats; Rats, Sprague-Dawley; RGS Proteins; Status Epilepticus | 2009 |
Cannabinoid-mediated inhibition of recurrent excitatory circuitry in the dentate gyrus in a mouse model of temporal lobe epilepsy.
Topics: Action Potentials; Animals; Arachidonic Acids; Blotting, Western; Cannabinoids; Dentate Gyrus; Disease Models, Animal; Endocannabinoids; Epilepsy, Temporal Lobe; Excitatory Postsynaptic Potentials; Glutamic Acid; Male; Mice; Mossy Fibers, Hippocampal; Photolysis; Pilocarpine; Polyunsaturated Alkamides; Receptor, Cannabinoid, CB1; Status Epilepticus; Synapses | 2010 |
Lipoic acid alters amino acid neurotransmitters content in rat hippocampus after pilocarpine-induced seizures.
Topics: Animals; Anticonvulsants; Aspartic Acid; Dialysis; Excitatory Amino Acids; gamma-Aminobutyric Acid; Glutamic Acid; Glycine; Hippocampus; Male; Pilocarpine; Rats; Rats, Wistar; Seizures; Status Epilepticus; Survival Analysis; Thioctic Acid | 2011 |
Early life LiCl-pilocarpine-induced status epilepticus reduces acutely hippocampal glutamate uptake and Na+/K+ ATPase activity.
Topics: Animals; Convulsants; Enzyme Activation; Glutamic Acid; Hippocampus; Lithium Chloride; Male; Nerve Degeneration; Pilocarpine; Rats; Rats, Wistar; Sodium-Potassium-Exchanging ATPase; Status Epilepticus | 2011 |
Lipoic acid effects on glutamate and taurine concentrations in rat hippocampus after pilocarpine-induced seizures.
Topics: Animals; Antioxidants; Chromatography, High Pressure Liquid; Glutamic Acid; Hippocampus; Male; Pilocarpine; Rats; Rats, Wistar; Seizures; Taurine; Thioctic Acid | 2011 |
Glutamate carboxypeptidase II (GCPII) inhibitor displays anti-glutamate and anti-cocaine effects in an invertebrate assay.
Topics: Animals; Cocaine; Glutamate Carboxypeptidase II; Glutamic Acid; Models, Animal; N-Methylaspartate; Organophosphorus Compounds; Pilocarpine; Planarians; Stereotyped Behavior | 2012 |
Increased cholecystokinin labeling in the hippocampus of a mouse model of epilepsy maps to spines and glutamatergic terminals.
Topics: Animals; CA1 Region, Hippocampal; Cholecystokinin; Dendritic Spines; Epilepsy; Excitatory Postsynaptic Potentials; Fluorescent Antibody Technique; Glutamic Acid; Hippocampus; Immunoenzyme Techniques; Immunohistochemistry; Mice; Mice, Inbred C57BL; Microscopy, Confocal; Microscopy, Electron; Pilocarpine; Presynaptic Terminals; Receptor, Cannabinoid, CB1; Scopolamine | 2012 |
Neuropeptide Y increases in vivo hippocampal extracellular glutamate levels through Y1 receptor activation.
Topics: Animals; Anticonvulsants; Glutamic Acid; Hippocampus; Male; Microdialysis; Neuropeptide Y; Pilocarpine; Rats; Rats, Wistar; Receptors, Neuropeptide Y; Seizures | 2012 |
Involvement of GABAergic and glutamatergic systems in the anticonvulsant activity of 3-alkynyl selenophene in 21 day-old rats.
Topics: Animals; Anticonvulsants; Cerebral Cortex; Excitatory Amino Acid Agonists; GABAergic Neurons; gamma-Aminobutyric Acid; Glutamic Acid; Hippocampus; In Vitro Techniques; Male; Organoselenium Compounds; Pilocarpine; Rats; Rats, Wistar; Seizures | 2012 |
Consequences of pilocarpine-induced status epilepticus in immunodeficient mice.
Topics: Animals; Brain; Cell Count; Cell Death; Glutamic Acid; Mice; Mice, Nude; Neurons; Pilocarpine; Proto-Oncogene Proteins c-fos; Seizures; Status Epilepticus | 2012 |
Transsynaptic signaling by activity-dependent cleavage of neuroligin-1.
Topics: Animals; Animals, Newborn; Biotinylation; Calcium-Binding Proteins; Cell Adhesion Molecules, Neuronal; Cells, Cultured; Cerebral Cortex; Chlorocebus aethiops; Dark Adaptation; Dendrites; Disease Models, Animal; Electric Stimulation; Electroporation; Enzyme Inhibitors; Excitatory Amino Acid Agents; Excitatory Postsynaptic Potentials; Female; Glutamic Acid; Green Fluorescent Proteins; Hippocampus; Luminescent Proteins; Matrix Metalloproteinase 9; Mice; Mice, Inbred C57BL; Mice, Transgenic; Microscopy, Confocal; Muscarinic Agonists; Mutation; Neural Cell Adhesion Molecules; Neurons; Organ Culture Techniques; Patch-Clamp Techniques; Photons; Pilocarpine; Plant Lectins; Potassium Chloride; Pregnancy; Pyridinium Compounds; Quaternary Ammonium Compounds; Red Fluorescent Protein; Signal Transduction; Status Epilepticus; Synaptic Transmission; Threonine; Transfection; Vesicular Glutamate Transport Protein 1 | 2012 |
Protective role of astrocytic leptin signaling against excitotoxicity.
Topics: Animals; Astrocytes; Astrocytoma; Cell Line, Tumor; Convulsants; Epilepsy; Female; Gene Expression Regulation; Glial Fibrillary Acidic Protein; Gliosis; Glutamic Acid; Hippocampus; Leptin; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Nerve Tissue Proteins; Neurotoxins; Pilocarpine; Receptors, Leptin; Recurrence; Signal Transduction; Up-Regulation | 2013 |
Anxiogenic-like profile of Wistar adult rats based on the pilocarpine model: an animal model for trait anxiety?
Topics: Animals; Anxiety; Avoidance Learning; Behavior, Animal; Cell Death; Disease Models, Animal; Dose-Response Relationship, Drug; Electroencephalography; Epilepsy, Temporal Lobe; Glutamic Acid; Hippocampus; Injections, Intraperitoneal; Male; Maze Learning; Neurons; Pilocarpine; Rats; Rats, Wistar; Time Factors | 2013 |
L-Theanine intake increases threshold for limbic seizures but decreases threshold for generalized seizures.
Topics: Animals; Disease Models, Animal; GABA Agents; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Hippocampus; Male; Mice; Mice, Inbred Strains; Microdialysis; Pentylenetetrazole; Pilocarpine; Seizures; Tea | 2013 |
Impaired motor learning attributed to altered AMPA receptor function in the cerebellum of rats with temporal lobe epilepsy: ameliorating effects of Withania somnifera and withanolide A.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anticonvulsants; Carbamazepine; Cerebellum; Disease Models, Animal; Epilepsy, Temporal Lobe; Excitatory Amino Acid Transporter 1; Gene Expression Regulation; Glutamate Decarboxylase; Glutamic Acid; Inositol 1,4,5-Trisphosphate; Learning Disabilities; Linear Models; Locomotion; Male; Motor Activity; Phytotherapy; Pilocarpine; Protein Binding; Psychomotor Performance; Rats; Rats, Wistar; Receptors, AMPA; RNA, Messenger; Time Factors; Tritium; Withania; Withanolides | 2013 |
Brain mitochondrial metabolic dysfunction and glutamate level reduction in the pilocarpine model of temporal lobe epilepsy in mice.
Topics: Amino Acids; Animals; Brain; Chromatography, High Pressure Liquid; Disease Models, Animal; Epilepsy, Temporal Lobe; Gas Chromatography-Mass Spectrometry; Glucose; Glutamic Acid; Magnetic Resonance Spectroscopy; Male; Mice; Mice, Inbred Strains; Mitochondria; Neurotransmitter Agents; Pilocarpine | 2013 |
Gabapentin administration reduces reactive gliosis and neurodegeneration after pilocarpine-induced status epilepticus.
Topics: Amines; Animals; Astrocytes; Cyclohexanecarboxylic Acids; Electroencephalography; Gabapentin; gamma-Aminobutyric Acid; Gliosis; Glutamic Acid; Hippocampus; Humans; Male; Nestin; Neuroglia; Neurons; Pilocarpine; Rats; Seizures; Status Epilepticus | 2013 |
Activation of muscarinic receptors protects against retinal neurons damage and optic nerve degeneration in vitro and in vivo models.
Topics: Animals; Animals, Newborn; Caspase 3; Cells, Cultured; Choline O-Acetyltransferase; Disease Models, Animal; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Glutamic Acid; Male; Muscarinic Agonists; Nerve Degeneration; Neurons; Optic Nerve; Pilocarpine; Rats; Rats, Sprague-Dawley; Receptors, Muscarinic; Reperfusion Injury; Retina | 2014 |
Transient muscarinic and glutamatergic stimulation of neural stem cells triggers acute and persistent changes in differentiation.
Topics: Animals; Chronic Disease; Disease Models, Animal; Epilepsy; GABAergic Neurons; Gap Junctions; Glutamic Acid; Hippocampus; Humans; Induced Pluripotent Stem Cells; Male; Mice; Muscarinic Agonists; Neural Stem Cells; Neurogenesis; Pilocarpine; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Receptors, Muscarinic | 2014 |
The mast cell stabilizer sodium cromoglycate reduces histamine release and status epilepticus-induced neuronal damage in the rat hippocampus.
Topics: Analysis of Variance; Animals; Anti-Asthmatic Agents; Anticonvulsants; Cell Count; Chromatography, High Pressure Liquid; Cromolyn Sodium; Disease Models, Animal; Electroencephalography; Fluoresceins; gamma-Aminobutyric Acid; Glutamic Acid; Hippocampus; Histamine; Male; Pilocarpine; Rats; Rats, Wistar; Status Epilepticus | 2015 |
PI3Kγ deficiency enhances seizures severity and associated outcomes in a mouse model of convulsions induced by intrahippocampal injection of pilocarpine.
Topics: Animals; Calcium; Calcium-Binding Proteins; Class Ib Phosphatidylinositol 3-Kinase; Cytokines; Disease Models, Animal; Doublecortin Domain Proteins; Enzyme Inhibitors; Glutamic Acid; Hippocampus; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Microfilament Proteins; Microtubule-Associated Proteins; Muscarinic Agonists; Neuropeptides; Pilocarpine; Prefrontal Cortex; Quinoxalines; Reaction Time; Seizures; Synaptosomes; Thiazolidinediones; Time Factors | 2015 |
Transcranial focal electrical stimulation reduces the convulsive expression and amino acid release in the hippocampus during pilocarpine-induced status epilepticus in rats.
Topics: Animals; Disease Models, Animal; gamma-Aminobutyric Acid; Glutamic Acid; Hippocampus; Male; Pilocarpine; Rats; Status Epilepticus; Transcranial Direct Current Stimulation | 2015 |
Increased extracellular levels of glutamate in the hippocampus of chronically epileptic rats.
Topics: Animals; Chromatography, High Pressure Liquid; Chronic Disease; Disease Models, Animal; Electroencephalography; Epilepsy; Extracellular Fluid; gamma-Aminobutyric Acid; Glutamic Acid; Hippocampus; Male; Microdialysis; Muscarinic Agonists; Pilocarpine; Rats; Rats, Sprague-Dawley; Scopolamine; Signal Transduction | 2015 |
Protein-caloric dietary restriction inhibits mossy fiber sprouting in the pilocarpine model of TLE without significantly altering seizure phenotype.
Topics: Animals; Caloric Restriction; Diet, Protein-Restricted; Disease Models, Animal; Electroencephalography; Epilepsy, Temporal Lobe; Glutamic Acid; Hippocampus; Male; Mossy Fibers, Hippocampal; Phenotype; Pilocarpine; Rats; Rats, Wistar; Seizures; Status Epilepticus | 2015 |
Transcranial focal electrical stimulation reduces seizure activity and hippocampal glutamate release during status epilepticus.
Topics: Animals; gamma-Aminobutyric Acid; Glutamic Acid; Hippocampus; Pilocarpine; Rats; Status Epilepticus; Transcranial Direct Current Stimulation | 2015 |
Expression pattern of NMDA receptors reveals antiepileptic potential of apigenin 8-C-glucoside and chlorogenic acid in pilocarpine induced epileptic mice.
Topics: Animals; Anticonvulsants; Antioxidants; Apigenin; Behavior, Animal; Chlorogenic Acid; Epilepsy; gamma-Aminobutyric Acid; Gene Expression Regulation; Glutamic Acid; Glutathione; Hippocampus; Male; Mice; Neuroprotective Agents; Nitric Oxide; Pilocarpine; Receptors, N-Methyl-D-Aspartate; Thiobarbituric Acid Reactive Substances | 2016 |
Propylparaben applied after pilocarpine-induced status epilepticus modifies hippocampal excitability and glutamate release in rats.
Topics: Action Potentials; Animals; Anticonvulsants; Cell Count; Diazepam; Disease Models, Animal; Electric Stimulation; Fluoresceins; Glial Fibrillary Acidic Protein; Glutamic Acid; Hippocampus; Male; Muscarinic Agonists; Parabens; Phosphopyruvate Hydratase; Pilocarpine; Rats; Rats, Wistar; Status Epilepticus | 2017 |
Modification of the natural progression of epileptogenesis by means of biperiden in the pilocarpine model of epilepsy.
Topics: Action Potentials; Animals; Autonomic Nervous System; Biperiden; Chronic Disease; Cytokines; Disease Models, Animal; Disease Progression; Epilepsy; Exploratory Behavior; gamma-Aminobutyric Acid; Glutamic Acid; Hippocampus; Male; Maze Learning; Muscarinic Agonists; Muscarinic Antagonists; Pilocarpine; Rats; Rats, Wistar | 2017 |
LC-MS/MS imaging with thermal film-based laser microdissection.
Topics: Acetylcholine; Animals; Choline; Chromatography, Liquid; Epilepsy; Female; gamma-Aminobutyric Acid; Glutamic Acid; Hippocampus; Laser Capture Microdissection; Mice, Inbred C57BL; Neurotransmitter Agents; Pilocarpine; Tandem Mass Spectrometry | 2018 |
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Topics: Animals; Antibodies; Anticonvulsants; Caspase 3; Disease Models, Animal; Drug Evaluation, Preclinical; Epilepsy; Glucose; Glutamic Acid; Hippocampus; Male; Mice, Inbred C57BL; Oxidation-Reduction; Pilocarpine; Sodium-Potassium-Exchanging ATPase; Tissue Culture Techniques | 2018 |
Commonalities and differences in extracellular levels of hippocampal acetylcholine and amino acid neurotransmitters during status epilepticus and subsequent epileptogenesis in two rat models of temporal lobe epilepsy.
Topics: Acetylcholine; Amino Acids; Animals; Aspartic Acid; Disease Models, Animal; Electroencephalography; Epilepsy; Epilepsy, Temporal Lobe; Female; Glutamic Acid; Hippocampus; Lysine; Microdialysis; Neurotransmitter Agents; Pilocarpine; Rats; Scopolamine; Seizures; Status Epilepticus; Temporal Lobe | 2019 |
The Anticonvulsant Effects of Baldrinal on Pilocarpine-Induced convulsion in Adult Male Mice.
Topics: Animals; Anticonvulsants; Brain; Disease Models, Animal; Epilepsy; gamma-Aminobutyric Acid; Glutamic Acid; Humans; Iridoids; Mice; Pilocarpine; Seizures | 2019 |
Inhibition of p38 MAPK regulates epileptic severity by decreasing expression levels of A1R and ENT1.
Topics: Animals; Anticonvulsants; Brain; Epilepsy; Equilibrative Nucleoside Transporter 1; Glutamic Acid; Hippocampus; Imidazoles; Male; Neurons; p38 Mitogen-Activated Protein Kinases; Pilocarpine; Pyridines; Rats; Rats, Sprague-Dawley; Receptor, Adenosine A1; Seizures; Signal Transduction; Status Epilepticus | 2020 |
Pretreatment with a glutamine synthetase inhibitor MSO delays the onset of initial seizures induced by pilocarpine in juvenile rats.
Topics: Animals; Brain; Disease Models, Animal; Glutamate-Ammonia Ligase; Glutamic Acid; Glutamine; Male; Methionine Sulfoximine; Pilocarpine; Rats, Sprague-Dawley; Seizures | 2021 |
Inhibition of Glutamate Release, but Not of Glutamine Recycling to Glutamate, Is Involved in Delaying the Onset of Initial Lithium-Pilocarpine-Induced Seizures in Young Rats by a Non-Convulsive MSO Dose.
Topics: Animals; Brain; Disease Progression; Dose-Response Relationship, Drug; Glutamic Acid; Glutamine; Lithium; Male; Methionine Sulfoximine; Pilocarpine; Rats; Rats, Sprague-Dawley; Secretory Pathway; Seizures | 2021 |