pilocarpic acid has been researched along with pilocarpine in 25 studies
| Studies (pilocarpic acid) | Trials (pilocarpic acid) | Recent Studies (post-2010) (pilocarpic acid) | Studies (pilocarpine) | Trials (pilocarpine) | Recent Studies (post-2010) (pilocarpine) |
|---|---|---|---|---|---|
| 26 | 2 | 4 | 7,334 | 340 | 1,528 |
| Protein | Taxonomy | pilocarpic acid (IC50) | pilocarpine (IC50) |
|---|---|---|---|
| Muscarinic acetylcholine receptor M1 | Rattus norvegicus (Norway rat) | 3.0267 | |
| Muscarinic acetylcholine receptor M3 | Rattus norvegicus (Norway rat) | 3.84 | |
| Muscarinic acetylcholine receptor M4 | Rattus norvegicus (Norway rat) | 3.84 | |
| Muscarinic acetylcholine receptor M5 | Rattus norvegicus (Norway rat) | 3.84 | |
| Muscarinic acetylcholine receptor M2 | Rattus norvegicus (Norway rat) | 3.84 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (24.00) | 18.7374 |
| 1990's | 8 (32.00) | 18.2507 |
| 2000's | 7 (28.00) | 29.6817 |
| 2010's | 4 (16.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Dunn, DL; Fan, TY; Sternitzke, KD | 1 |
| Auriola, S; Järvinen, T; Peura, P; Suhonen, P; Urtti, A; Vepsäläinen, J | 1 |
| Järvinen, T; Naumanen, H; Peura, P; Suhonen, P; Urtti, A | 1 |
| Goldhoorn, PB; Kuks, PF; Weekers, LE | 1 |
| Costa-Segarra, J; Gomez-Gomar, A; Gonzalez-Aubert, M | 1 |
| Durif, C; Kister, G; Puech, A; Ribes, M | 1 |
| Bundgaard, H; Falch, E; Larsen, C; Mikkelson, TJ | 1 |
| Ellis, PP; Gal, J; Rendi, MA | 1 |
| Beyerman, HC; Maat, L; Noordam, A | 1 |
| Kennedy, JM; McNamara, PE | 1 |
| Kuwano, M; Matsuura, K; Takashina, H | 1 |
| Aström, O; Persson, K | 1 |
| Bohle, JF; Jonkman, JH; Oosterhuis, B; Tinke, AP; van de Merbel, NC | 1 |
| Bayne, WF; Birk, KL; Cairns, AM; Demetriades, JL; Dru, JD; Hsieh, JY; Matuszewski, BK; Musson, DG; Rogers, JD; Woolf, EJ | 1 |
| Arizzi, MN; Correa, M; Ishiwari, K; Salamone, JD; Wisniecki, A | 1 |
| Becker, AJ; Blümcke, I; Chen, J; Elger, CE; Normann, S; Schramm, J; Sochivko, D; Wiestler, OD; Zien, A | 1 |
| Brooks-Kayal, AR; Coulter, DA; Hsu, FC; Raol, YH; Zhang, G | 1 |
| Fahnestock, M; McIntyre, DC; Racine, RJ; Xu, B | 1 |
| Bonan, CD; Bruno, AN; de Paula Cognato, G; Sarkis, JJ; Vuaden, FC | 1 |
| Endo, T; Fukami, T; Hara, Y; Hasunuma, T; Momose, Y; Nakajima, M; Yokoi, T | 1 |
| Argüelles, D; Carmona, JU; Deulofeu, R; Martínez-Puig, D; Prades, M | 1 |
| Fukami, T; Hioki, T; Nakajima, M; Yokoi, T | 1 |
| Olson, JB; Shirey, TB; Thacker, RW | 1 |
| Bronson, E; Cox, SK; Kilburn, JJ; Kottyan, J; Wack, AN | 1 |
| Branstetter, D; Dougall, WC; Giner, G; Huang, LY; Lindeman, GJ; Lok, SW; Mann, GB; Nolan, E; Pal, B; Rohrbach, K; Smyth, GK; Soriano, R; Vaillant, F; Visvader, JE; Whitehead, L | 1 |
2 trial(s) available for pilocarpic acid and pilocarpine
| Article | Year |
|---|---|
Determination of pilocarpic acid in human plasma by capillary gas chromatography with mass-selective detection.
Topics: Gas Chromatography-Mass Spectrometry; Humans; Hydrolysis; Pilocarpine; Reproducibility of Results; Sensitivity and Specificity | 1998 |
Effect of the administration of an oral hyaluronan formulation on clinical and biochemical parameters in young horses with osteochondrosis.
Topics: Animals; Dinoprostone; Double-Blind Method; Horse Diseases; Horses; Hyaluronic Acid; Osteochondrosis; Pilocarpine; Synovial Fluid | 2009 |
23 other study(ies) available for pilocarpic acid and pilocarpine
| Article | Year |
|---|---|
High-performance liquid chromatographic determination of pilocarpine hydrochloride and its degradation products using a beta-cyclodextrin column.
Topics: beta-Cyclodextrins; Chromatography, High Pressure Liquid; Cyclodextrins; Pilocarpine | 1992 |
Synthesis and identification of pilocarpic acid diesters, prodrugs of pilocarpine.
Topics: Chromatography, Liquid; Esters; Magnetic Resonance Spectroscopy; Mass Spectrometry; Pilocarpine; Prodrugs | 1991 |
Determination of physicochemical properties, stability in aqueous solutions and serum hydrolysis of pilocarpic acid diesters.
Topics: Chromatography, High Pressure Liquid; Esters; Humans; Hydrolysis; Kinetics; Pilocarpine; Structure-Activity Relationship | 1991 |
Decomposition of pilocarpine eye drops assessed by a highly efficient high pressure liquid chromatographic method.
Topics: Chromatography, High Pressure Liquid; Drug Stability; Indicators and Reagents; Ophthalmic Solutions; Pilocarpine | 1990 |
HPLC method for the simultaneous determination of pilocarpine, isopilocarpine, pilocarpic acid and isopilocarpic acid.
Topics: Chromatography, High Pressure Liquid; Indicators and Reagents; Pilocarpine; Solutions; Spectrophotometry, Ultraviolet; Tetraethylammonium Compounds | 1989 |
[Rapid semiquantitative evaluation by thin-layer chromatography of pilo- and isopilocarpic acids in eyedrops with a pilocarpine base].
Topics: Chromatography, Thin Layer; Ophthalmic Solutions; Pilocarpine | 1986 |
Pilocarpine prodrugs I. Synthesis, physicochemical properties and kinetics of lactonization of pilocarpic acid esters.
Topics: Chemical Phenomena; Chemistry, Physical; Chromatography, High Pressure Liquid; Drug Stability; Enzymes; Kinetics; Lactones; Pilocarpine; Solubility; Spectrophotometry, Ultraviolet | 1986 |
High-performance liquid chromatographic assay for pilocarpine in aqueous humor.
Topics: Animals; Aqueous Humor; Chromatography, High Pressure Liquid; Isomerism; Male; Pilocarpine; Rabbits | 1984 |
Quantitative determination of pilocarpine, isopilocarpine, pilocarpic acid, and isopilocarpic acid in clinical ophthalmic pilocarpine formulations by reversed-phase liquid chromatography.
Topics: Chromatography, High Pressure Liquid; Isomerism; Ophthalmic Solutions; Pilocarpine | 1981 |
High-performance liquid chromatographic analysis of pilocarpine hydrochloride, isopilocarpine, pilocarpic acid and isopilocarpic acid in eye-drop preparations.
Topics: Australia; Chromatography, High Pressure Liquid; Ophthalmic Solutions; Pilocarpine; United States | 1981 |
Determination of pilocarpine in aqueous humour by liquid chromatography-atmospheric pressure chemical ionization mass spectrometry.
Topics: Animals; Aqueous Humor; Atmospheric Pressure; Chromatography, Liquid; Kinetics; Male; Mass Spectrometry; Pilocarpine; Rabbits | 1993 |
Fractional factorial design optimization of the separation of pilocarpine and its degradation products by capillary electrophoresis.
Topics: Electrophoresis, Capillary; Hydrolysis; Miotics; Multivariate Analysis; Pilocarpine; Stereoisomerism | 1997 |
Determination of pilocarpine, isopilocarpine, pilocarpic acid and isopilocarpic acid in human plasma and urine by high-performance liquid chromatography with tandem mass spectrometric detection.
Topics: Chromatography, High Pressure Liquid; Evaluation Studies as Topic; Humans; Mass Spectrometry; Pilocarpine; Ultrafiltration | 1998 |
Motor effects of GABA(A) antagonism in globus pallidus: studies of locomotion and tremulous jaw movements in rats.
Topics: Animals; Behavior, Animal; Bicuculline; Depression, Chemical; Dose-Response Relationship, Drug; Drug Interactions; GABA Antagonists; Globus Pallidus; Haloperidol; Jaw; Locomotion; Male; Movement; Pilocarpine; Rats; Rats, Sprague-Dawley; Tremor | 2003 |
Correlated stage- and subfield-associated hippocampal gene expression patterns in experimental and human temporal lobe epilepsy.
Topics: Animals; Cluster Analysis; Disease Models, Animal; Epilepsy, Temporal Lobe; Gene Expression; Hippocampus; Humans; Male; Oligonucleotide Array Sequence Analysis; Pilocarpine; Rats; Rats, Wistar; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Time Factors | 2003 |
Effects of status epilepticus on hippocampal GABAA receptors are age-dependent.
Topics: Age Factors; Animals; Animals, Newborn; Blotting, Northern; Cell Survival; Cerebral Cortex; Dose-Response Relationship, Drug; Drug Interactions; Electroencephalography; GABA Agonists; Gene Expression Regulation; Hippocampus; In Vitro Techniques; Lithium Chloride; Patch-Clamp Techniques; Pilocarpine; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Status Epilepticus; Video Recording; Zolpidem | 2004 |
Strain differences affect the induction of status epilepticus and seizure-induced morphological changes.
Topics: Animals; Cell Count; Hippocampus; Male; Mossy Fibers, Hippocampal; Neurons; Pilocarpine; Rats; Rats, Long-Evans; Rats, Wistar; Reaction Time; Seizures; Species Specificity; Status Epilepticus; Time Factors | 2004 |
Ontogenetic profile of ectonucleotidase activities from brain synaptosomes of pilocarpine-treated rats.
Topics: 5'-Nucleotidase; Adenine Nucleotides; Adenosine Triphosphatases; Age Factors; Analysis of Variance; Animals; Animals, Newborn; Cerebral Cortex; Disease Models, Animal; Epilepsy; Female; Hippocampus; Male; Pilocarpine; Rats; Sex Factors; Synaptosomes | 2005 |
Genetic polymorphisms of CYP2A6 affect the in-vivo pharmacokinetics of pilocarpine.
Topics: Administration, Oral; Adult; Aged; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP2A6; Humans; Male; Middle Aged; Muscarinic Agonists; Pilocarpine; Polymorphism, Genetic | 2008 |
Human paraoxonase 1 is the enzyme responsible for pilocarpine hydrolysis.
Topics: Adult; Animals; Aryl Hydrocarbon Hydroxylases; Aryldialkylphosphatase; Calcium Chloride; Cell Line; Cytochrome P-450 CYP2A6; Electrophoresis, Polyacrylamide Gel; Female; Humans; Hydrolysis; Immunoblotting; Insecta; Kinetics; Male; Microsomes, Liver; Middle Aged; Pilocarpine; Polymorphism, Restriction Fragment Length; Substrate Specificity; Transfection; Young Adult | 2011 |
Composition and stability of bacterial communities associated with granular activated carbon and anthracite filters in a pilot scale municipal drinking water treatment facility.
Topics: Bacteria; Carbon; Cities; Coal; Filtration; Pilocarpine; Water Microbiology; Water Purification | 2012 |
Pharmacokinetics of tramadol and its primary metabolite O-desmethyltramadol in African penguins (Spheniscus demersus).
Topics: Analgesics, Opioid; Animals; Pilocarpine; Spheniscidae; Tramadol | 2014 |
RANK ligand as a potential target for breast cancer prevention in BRCA1-mutation carriers.
Topics: Animals; Bone Density Conservation Agents; BRCA1 Protein; Breast; Breast Neoplasms; Carcinogenesis; Cell Proliferation; Denosumab; Disease Models, Animal; DNA Repair; Female; Flow Cytometry; Heterozygote; Humans; Immunohistochemistry; Mice; Molecular Targeted Therapy; Mutation; Neoplasm Transplantation; Organoids; Pilocarpine; Prophylactic Mastectomy; RANK Ligand; Receptor Activator of Nuclear Factor-kappa B; Reverse Transcriptase Polymerase Chain Reaction; Stem Cells; Tumor Suppressor Proteins; Xenograft Model Antitumor Assays | 2016 |