Page last updated: 2024-08-16

pifithrin and toluene

pifithrin has been researched along with toluene in 359 studies

Research

Studies (359)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	3 (0.84)	18.2507
2000's	152 (42.34)	29.6817
2010's	184 (51.25)	24.3611
2020's	20 (5.57)	2.80

Authors

Authors	Studies
Chernov, MV; Christov-Tselkov, K; Coon, JS; Gudkov, AV; Komarov, PG; Komarova, EA; Kondratov, RV	1
Ferber, D	1
Jacquemin-Sablon, A	1
Grosu, AL; Molls, M; Stadler, P	1
Gudkov, AV; Komarova, EA	3
Howell, SB	1
Camandola, S; Chan, SL; Culmsee, C; Greig, NH; Guo, Z; Mattson, MP; Yu, QS; Zhu, X	1
Dubinsky, JM; Lakkaraju, A; Low, WC; Rahman, YE	1
Mahyar-Roemer, M; Roemer, K	1
Hernández, G; López-Rivas, A; Lorenzo, E; Quesada, AJ; Redondo, JM; Rodríguez, A; Ruiz-Ruiz, C	1
Chopin, V; Jouy, N; Le Bourhis, X; Toillon, RA	1
Akin, D; Cohen, RJ; Feldherr, CM	1
Bassi, L; Carloni, M; Fonti, E; Meschini, R; Palitti, F; Palma de la Peña, N	1
Horal, M; Loeken, MR; Pani, L	1
Begum, RA; Farah, IO; Ishaque, AB	2
Arai, M; Fujiwara, K; Ikeda, H; Inoue, Y; Kimura, S; Ogata, I; Omata, M; Tejima, K; Tomiya, T; Yanase, M	1
Bruch, HP; El-Gibaly, AM; Menger, MD; Scheuer, C; Strik, MW; Vollmar, B	1
Dabrowska-Iwanicka, A; Giermasz, A; Golab, J; Grzela, T; Hoser, G; Jakóbisiak, M; Jalili, A; Makowski, M; Marczak, M; Olszewska, D	1
Cadet, JL; Cutler, RG; Duan, W; Greig, NH; Guo, Z; Ladenheim, B; Mattson, MP; Oyler, J; Yu, QS; Zhu, X	1
Gong, Q; Hollmann, AC; Owens, T	1
Dagher, PC; Kelly, KJ; Plotkin, Z; Vulgamott, SL	1
Lin, Y; Waldman, AS; Waldman, BC	1
Bartholomew, J; Char, D; Cleaver, JE; Crowley, E; Feeney, L; Limoli, CL	1
Alves da Costa, C; Ancolio, K; Checler, F; Mattson, MP	1
Chernov, MV; Gudkov, AV; Komarov, PG; Komarova, EA; Neznanov, N; Wang, K	1
Menger, MD; Roemer, K; Schäfer, T; Scheuer, C; Vollmar, B	1
Campana, AL; Falempin, M; Lohof, AM; Mariani, J; Picquet, F; Rondi-Reig, L; Tobin, C; Weitzman, JB	1
Bardini, P; Danni, O; Guglielmotto, M; Marra, L; Parola, M; Santoro, G; Tabaton, M; Tamagno, E	1
Chan, SL; Gilman, CP; Greig, N; Guo, Z; Mattson, MP; Zhu, X	1
Ding, D; Liu, W; Salvi, R; Zhang, M	1
Akimitsu, N; Hamamoto, H; Kamura, K; Kikuchi, A; Sakaguchi, A; Sekimizu, K; Toné, S	1
Bode, AM; Dong, Z; Kaji, A; Ma, WY; Nomura, M; She, QB; Zhang, Y	1
Balajee, AS; Lorenti Garcia, C; Palitti, F; Pepe, G; Proietti De Santis, L; Worboys, AM	1
Bet, A; Carli, M; Dalla Vecchia, F; Diaspro, A; Gatto, B; Palù, G; Palumbo, M; Pecere, T; Salata, C; Sarinella, F	1
Campbell, KJ; Perkins, ND; Rocha, S; Roche, KC	1
Behnke, H; Camandola, S; Culmsee, C; El-Metainy, S; Junker, V; Krieglstein, J; Mattson, MP; Retiounskaia, M; Schwarz, S; Siewe, J	1
Mocanu, MM; Yellon, DM	1
Bonini, P; Cardinale, A; Cicconi, S; Ciotti, MT; Marlier, LN; Serafino, AL; Vitale, C	1
Nakashima, K; Nakaso, K; Takeshima, T; Yano, H; Yoshimoto, Y	1
Chen, Z; Chua, BH; Chua, CC; Gao, J; Hamdy, R; Landy, CL; Liu, X	1
Dimanche-Boitrel, MT; Fardel, O; Gardyn, C; Gilot, D; Guillouzo, A; Huc, L; Lagadic-Gossmann, D; Rissel, M	1
Christov, K; Goldblum, JR; Golovkina, TV; Gudkov, AV; Komarova, EA; Kondratov, RV; Wang, K	1
Aharonowiz, M; Greig, NH; Leker, RR; Ovadia, H	1
Galigniana, MD; Harrell, JM; Kwok, RP; Ljungman, M; Morishima, Y; Murphy, PJ; Pratt, WB	1
El-Gibaly, AM; Menger, MD; Scheuer, C; Vollmar, B	1
Hu, H; Jiang, C; Lü, J; Malewicz, B; Wang, Z	1
Dong, Z; Hsu, S; Jiang, M; Wang, CY; Yi, X	1
Golovko, O; Lou, YR; Nazarova, N; Qiao, S; Tuohimaa, P	1
Chao, JI; Kuo, PC; Liu, HF	1
Daida, H; Kashiwakura, Y; Kumon, H; Kusumi, N; Nasu, Y; Sawamura, T; Sumiyoshi, K; Takei, K; Watanabe, M; Yamada, H	1
Boltze, C; Diab-Assef, M; Foltzer-Jourdainne, C; Gali-Muhtasib, H; Hartig, R; Roessner, A; Rohrbeck, A; Schneider-Stock, R; Schönfeld, P	1
Kozubík, A; Machala, M; Plísková, M; Vojtesek, B; Vondrácek, J	1
Csapo, Z; Keszler, G; Sasvari-Szekely, M; Spasokoukotskaja, T; Staub, M; Virga, S	2
Engelstein, R; Gabizon, R; Greig, NH; Grigoriadis, N; Ovadia, H	1
Colohan, AR; Yamaguchi, M; Zhang, JH; Zhou, C	1
Burlet, S; Dono, R; Garino, C; Kraus, JL; Laras, Y; Maina, F; Moumen, A; Pietrancosta, N; Quéléver, G	1
Barchéchath, SD; Carson, DA; Corr, M; Cottam, HB; Tawatao, RI	2
Benbrook, DM; Gould, NS; Guruswamy, S; Kamelle, SA; Rutledge, TL; Tillmanns, TD	1
Cairncross, JG; Mymryk, JS; Xu, GW	1
Hoagland, EM; Hoagland, MS; Swanson, HI	1
Kaushal, GP; Kaushal, V; Seth, R; Shah, SV; Yang, C	1
He, J; Huang, C; Li, J; Ma, Q; Ouyang, W; Tong, Q; Wang, J; Wei, L; Zhang, Z	1
Bordel, R; Eipel, C; Glawe, C; Menger, MD; Schuett, H; Vollmar, B	1
Hardcastle, IR; Mirza, AR; Walton, MI; Wilson, SC; Workman, P	1
Banasik, M; Jesko, H; Strosznajder, RP; Tanaka, S	1
Chechlacz, M; Gilliams-Francis, K; Lamonica, K; Lin, SL; Liu, J; Naegele, JR; Navarro-Quiroga, I; Neema, M	1
Aninat, C; Fardel, O; Le Vee, M; Sparfel, L; Van Grevenynghe, J	1
Chan, SL; Chan, SS; Fiscus, RR; Fraser, M; Tsang, BK	1
Chandel, N; Kamp, DW; Panduri, V; Soberanes, S; Surapureddi, S; Weitzman, SA	1
Jimenez Del Rio, M; Velez-Pardo, C	1
Bowen, JM; Cummins, AG; Gibson, RJ; Keefe, DM	1
Chie, EK; Ha, SW; Kao, GD; Kim, IA; Kim, IH; Kim, JH; Kim, JS; Park, CI; Shin, JH; Wu, HG	1
Charlot, JF; Mougin, C; Nicolier, M; Prétet, JL	1
Cheng, XY; Ji, L; Luan, B; Qiu, L; Wang, XY; Xu, FL; Zhu, CL	1
Fu, T; He, YJ; Liu, BH; Luo, DL; Tong, WD; Zhang, AP; Zhang, LY	1
Nedelcu, AM	1
Chua, BH; Chua, CC; Gao, J; Hamdy, RC; Liu, X	1
Cahill, J; Calvert, JW; Solaroglu, I; Zhang, JH	1
Bähr, M; Dono, R; Kraus, JL; Lamballe, F; Lingor, P; Maina, F; Moumen, A; Pietrancosta, N; Planchamp, V	1
Agarwal, C; Agarwal, R; Singh, RP; Tyagi, A	1
Maki, K; Mitani, K; Waga, K; Yamagata, T	1
Arai, N; Fujishita, T; Fujita, T; Hayashi, R; Kawagishi, Y; Kobayashi, M; Maruyama, M; Matsui, S; Miwa, T; Miyabayashi, K; Shinoda, C; Sugiyama, E; Yamada, T	1
Bosykh, DA; Burdelya, LG; Chernova, OB; Gudkov, AV; Komarov, PG; Komarova, EA; Macklis, RM; Pavlovska, I; Sathe, S; Shyshynova, I; Skaliter, R; Strom, E	1
Francis, RJ; Lo, CW	1
Côté, CH; Frenette, J; Marsolais, D	1
Bundinger, GR; Ghio, A; Kamp, DW; Mutlu, GM; Panduri, V; Soberanes, S	1
Heininger, D; Hochegger, K; Huber, JM; Koppelstaetter, C; Mayer, G; Rosenkranz, AR; Tagwerker, A	1
Henson, R; Lang, M; Meng, F; Patel, T; Wehbe, H	1
Browder, T; Burdelya, LG; DiCorleto, PE; Folkman, J; Gudkov, AV; Hill, JE; Komarova, EA; Mavrakis, L; Tararova, ND	1
Cavalieri, TA; Hock, CE; Liu, P; Xu, B	2
Kersten, JR; Krolikowski, JG; Pagel, PS; Pratt, PF; Venkatapuram, S; Wang, C; Warltier, DC; Weihrauch, D	1
Bowen, JM; Chan, TW; Cummins, AG; Gibson, RJ; Keefe, DM; Prabowo, AS; Stringer, AM	1
Bundgaard, B; Höllsberg, P; Kaspersen, MD; Kofod-Olsen, E; Øster, B	1
Del Rio, MJ; Morales, AT; Olivera-Angel, M; Velez-Pardo, C	1
Bennett, MC; Chase, TN; Han, R; Li, YL; Liang, ZQ; Qin, ZH; Wang, XX; Wang, Y; Zhao, XL	1
Duffy, KT; Wickstrom, E	1
Citron, BA; Dennis, JS; Eve, DJ	1
Jourd'Heuil, D; Jourd'Heuil, FL; Lu, Q	1
Ardeshiri, A; Culmsee, C; Engel, D; Hoffmann, F; Landshamer, S; Plesnila, N; Retiounskaia, M; von Baumgarten, L; Wagner, E; Zimmermann, R	1
Dong, G; Dong, Z; Megyesi, J; Price, PM; Wei, Q; Yang, T	1
Ng, LT; Wu, SJ	1
Egashira, N; Itoh, Y; Kawashiri, T; Matsuo, M; Oishi, R; Yano, T	1
Chen, WR; Wang, X; Wu, Y; Xing, D	1
Freer, M; Mei, Y; Shaltouki, A; Weyman, CM	1
Allen, J; Avery-Kiejda, KA; Hersey, P; Mhaidat, NM; Scott, RJ; Zhang, XD	1
Carlisi, D; D'Anneo, A; Di Fazio, P; Di Leonardo, E; Emanuele, S; Lauricella, M; Tesoriere, G; Vassallo, B; Vento, R	1
Dunsmore, K; Ilangovan, G; Roy, S; Sen, CK; Venkatakrishnan, CD; Wani, A; Wong, H; Zweier, JL	1
Gupta, S; Shukla, S	1
Chen, CH; Hu, Q; Luan, LJ; Qin, LH; Shi, XZ; Yan, JH; Yang, L; Yang, XM; Zhao, J; Zhou, CM	1
Davidson, W; Dicker, AP; Kari, G; Kashi, O; Ren, Q; Rodeck, U	1
Bundgaard, B; Höllsberg, P; Kofod-Olsen, E; Øster, B	1
Banerjee, S; Bhattacharyya, A; Bhattacharyya, S; Chakraborty, J; Chattopadhyay, S; Choudhuri, T; Das, T; Lahiry, L; Mandal, D; Sa, G; Saha, B	1
Dong, Z; Jiang, M; Periyasamy-Thandavan, S; Smith, R; Wei, Q; Yin, XM	1
Zuco, V; Zunino, F	1
Casaccia-Bonnefil, P; DeVellis, J; Ghiani, CA; Kim, JY; Li, J; Liu, A; Sandoval, J	1
Cho, KH; Chung, JH; Kim, S; Kim, Y; Lee, DH; Lee, Y	1
Clair, DK; García-Cazarín, ML; Piascik, MT; Smith, JL	1
Aebersold, DM; Berthou, S; Blank-Liss, W; Ganapathipillai, SS; Greiner, RH; Manley, PW; Medová, M; Rothen-Rutishauser, B; Streit, B; Zimmer, Y	1
Bischof, P; Cohen, M; Irion, O; Wuillemin, C	1
Gao, B; Liu, L; Wu, Y; Xing, D	1
Erwin, KN; Gefroh, HA; Grimes, AC; Hunter, GL; Kirby, ML; Stadt, HA; Tsai, HJ	1
Cwynarski, K; Duke, VM; Hart, SM; Hoffbrand, AV; Howard-Reeves, JD; Kottaridis, PD; Nacheva, EP; Prentice, AG; Steele, AJ; Vassilev, LT; Wickremasinghe, RG; Yogashangary, BC	1
Amour, J; Krolikowski, JG; Pagel, PS; Pratt, PF; Shim, YH; Warltier, DC; Weihrauch, D	1
Ding, B; Liang, CS; Liu, J; Mao, W	1
Dagher, PC; Hosein, M; Knipe, NL; Mang, HE; Plotkin, Z; Sutton, TA; Wilkinson, J; Wittenborn, J; Zak, K	1
Ahn, EK; Lee, JY; Lee, KH; Lim, Y; Yoon, HK; Yun, YP	1
Joshi, SD; Karunakaran, S; Meka, DP; Mishra, M; Ravindranath, V; Saeed, U; Seth, P; Valli, RK	1
Campbell, VA; Fogarty, MP; Gowran, A; McCormack, RM; Murphy, D; Noonan, J	1
Berger, MS; Dinca, EB; Haas-Kogan, DA; James, CD; Lu, KV; Pieper, RO; Prados, MD; Sarkaria, JN; Vandenberg, SR	1
Bakalska, M; Coffigny, H; Duquenne, C; Frydman, R; Guerquin, MJ; Habert, R; Lambrot, R; Livera, G; Rouiller-Fabre, V	1
Chan, PH; Endo, H; Myer, DJ; Niizuma, K; Nito, C	1
Castranio, T; Mishina, Y	1
Amano, Y; Hachiya, A; Kitahara, T; Murase, D; Ohuchi, A; Takema, Y	1
Essmann, F; Graupner, V; Jänicke, RU; Neise, D; Schulze-Osthoff, K; Sohn, D	1
Konoplyannikov, AG; Konoplyannikova, OA; Proskuryakov, SY; Shevchenko, LI; Tsyb, AF; Verkhovskii, YG	1
Fukunaga, K; Gu, ZL; Han, F; Han, R; Liang, ZQ; Qin, ZH; Wang, Y; Wu, JC; Zhang, X; Zhang, XD	1
Arora, R; Jain, SK; Kumar, R; Sharma, A; Sharma, RK; Singh, PK	1
Marchenko, ND; Moll, UM; Vaseva, AV	1
Katano, M; Kato, H; Maruyama, M; Masui, S; Mizuno, Y; Nishimoto, M; Nomura, J; Okazaki, Y; Okuda, A; Zhang, J	1
Liu, L; Xing, D; Zhang, Y	1
Chou, J; Greig, NH; Hoffer, BJ; Kuo, CC; Luo, Y; Shen, H; Wang, Y	1
Cervinka, M; Rudolf, E; Rudolf, K	1
Chen, GS; Gu, Y; Li, FF; Li, H; Li, Q; Liu, F; Ye, J; Zhang, F; Zhang, LY	1
Abid-Essefi, S; Bacha, H; Bouaziz, C; Brenner, C; Lemaire, C; Martel, C; Sharaf el dein, O	1
Fujishiro, T; Hashimoto, S; Hayashi, S; Kanzaki, N; Kuroda, R; Kurosaka, M; Nishiyama, T; Takebe, K	1
Ikejima, T; Onodera, S; Tashiro, S; Wu, D; Wu, Y; Zhang, Y	1
Asare, N; Brunborg, G; Holme, JA; Låg, M; Lagadic-Gossmann, D; Landvik, N; Lecureur, V; Podechard, N; Rissel, M; Solhaug, A; Tekpli, X	1
Gao, Q; Kang, KB; Wong, MC; Yong, SK; Zhu, C	1
Aloi, C; Altieri, P; Barisione, C; Barsotti, A; Brunelli, C; Fugazza, G; Garibaldi, S; Ghigliotti, G; Spallarossa, P	1
Grounds, MD; McIldowie, MJ; Piggott, MJ; Shavlakadze, T; Waters, FJ	1
Concannon, CG; Engel, T; Hatazaki, S; Henshall, DC; Jimenez-Mateos, EM; Murphy, BM; Prehn, JH; Woods, I	1
Fu, P; Huang, XR; Lai, KN; Lan, HY; Liu, F; Zhou, L	1
Davenport, CM; Hooper, C; Pocock, JM; Sevastou, IG	1
Misra, UK; Pizzo, SV	1
Blazar, BR; Goren, EM; Gudkov, AV; Holländer, GA; Kelly, RM; Komarova, EA; Mueller, SN; Osborn, MJ; Scott, HS; Stefanski, HE; Taylor, PA	1
Das, HK; Lee, S	1
Aoki, S; Enomoto, A; Funatsu, O; Hosoi, Y; Ikekita, M; Ito, A; Matsumoto, Y; Morita, A; Nanao, T; Ohya, S; Suzuki, N; Tanaka, K; Wang, B; Yamamoto, S; Yoshino, M; Zhu, J	1
Cao, Y; Dong, XX; Gu, ZL; Han, R; Liang, ZQ; Qin, ZH; Wang, Y; Wu, JC	1
Babu, D; Kim, JA; Kim, JM; Kwak, MK; Kwon, TK; Lee, YR; Park, MA; Thapa, D	1
Berni, A; Mancinelli, P; Meschini, R; Ortenzi, V; Palitti, F	2
Antoch, MP; Gudkov, AV; Komarov, PG; Komarova, EA; Leonova, KI; Novototskaya, LR; Shneyder, J; Toshkov, IA	1
Akenaga, H; Ando, S; Aoyama, K; Arizono, K; Furukawa, T; Ikeda, R; Komatsu, M; Maeda, Y; Sumizawa, T; Takeuchi, T; Takumi, S	1
Beckman, BS; Patel, B; Struckhoff, AP	1
Chang, H; Jiang, H; Saha, MN	1
Lei, KY; Schoene, NW; Shih, RS; Wong, SH; Zhang, JJ	1
Budach, V; Freyer, D; Konschak, R; Schroeder, G; Schulze, J; Sinn, B; Tinhofer, I	1
Adijiang, A; Bolati, D; Dateki, M; Enomoto, A; Nishijima, F; Niwa, T; Shimizu, H	1
Chen, B; Longtine, MS; Nelson, DM; Sadovsky, Y	1
Abayasekara, N; Berliner, N; Currie, T; Dutt, S; Ebert, BL; Khanna-Gupta, A; Kutok, JL; Lin, K; Megerdichian, C; Mullally, A; Narla, A; Wilson, FH	1
Bae, SY; Cho, DH; Choi, MY; Han, J; Hur, SM; Kim, S; Koo, M; Lee, JE; Lee, SK; Nam, SJ; Shin, I; Yang, JH	1
Braun, T; Buerke, M; Ebelt, H; Köhler, K; Lu, D; Müller-Werdan, U; Schlitt, A; Werdan, K; Xu, J; Zhang, Y	1
Liu, L; Nagase, H; Park, AM; Suzuki, YJ; Szwergold, N; Vinod Kumar, S; Wong, CM	1
Averill-Bates, DA; Pallepati, P	1
Bouçada Inácio Peixoto, E; Butori Lopes de Faria, J; Homsi, E; Janino, P; Machado de Brito, S; Mota da Silva, S	1
Di, SM; Meng, R; Qian, AR; Shang, P; Shi, DY; Wang, JF; Xu, HY	1
Fan, XQ; Lin, F; Qin, ZH; Xing, CG; Zhao, K; Zhu, BS	1
Li, Y; Liu, X; Rong, F	1
Chou, J; Greig, NH; Hoffer, BJ; Reiner, D; Wang, Y	1
Christodoulou, MS; Colombo, F; De Cesare, M; Ieronimo, G; Passarella, D; Zuco, V; Zunino, F	1
Côrte-Real, M; Coutinho, I; Gonçalves, J; Pereira, C; Pereira, G; Saraiva, L	1
Alonso, M; Fernández-Cruz, ML; Herradón, B; Mann, E; Navas, JM; Valdehita, A	1
Hou, J; Huang, W; Li, Y; Liu, B; Lv, A; Xing, Y; Yan, X	1
Hu, J; Peng, Q; Qiu, J; Wang, G; Zheng, Y	1
Chen, C; Dong, D; Li, Z; Lin, H; Lu, Y; Luo, X; Wang, Z; Xiao, J; Yang, B	1
Culmsee, C; Hagberg, H; Heijnen, CJ; Kavelaars, A; Nijboer, CH; van Bel, F; van der Kooij, MA; van Velthoven, CT; Zijlstra, J	1
Adijiang, A; Bolati, D; Dateki, M; Enomoto, A; Muteliefu, G; Nishijima, F; Niwa, T; Shimizu, H	1
Choi, HR; Kang, HT; Kim, SY; Lee, KB; Park, SC	1
Asami, O; Hirano, M; Tanaka, S	1
Lei, H; Liu, Q; Ma, KH; Xia, Y; Yuan, XM	1
Kanouchi, H; Nakari, M; Oka, T	1
Anderson, MD; Dagher, PC; Hato, T; Karozos, SC; Knipe, NL; Lee, SY; Mai, EM; Mang, HE; Plotkin, Z; Sutton, TA	1
Chou, YP; Ho, CJ; Huang, CC; Lu, PJ; Tu, YF	1
Ahn, CW; Cha, BS; Han, SJ; Kim, SH; Lee, BW; Lee, EY; Lee, HC; Wang, HJ	1
Ghavami, S; Halayko, AJ; Klonisch, T; Mutawe, MM; Schaafsma, D; Unruh, H; Yeganeh, B	1
Chen, M; Eibl, G; Go, VL; Hines, OJ; King, JC; Li, G; Lu, QY; Moro, A; Reber, HA; Takahashi, H	1
Hao, Z; Huang, Y; Li, S; Lv, Y; Purbey, BK; Radha, G	1
Guo, JG; Guo, ZH; Xie, SQ; Zhang, YH	1
Fan, S; Ikejima, T; Li, L; Onodera, S; Qi, M; Tashiro, S; Yao, G; Yu, Y	1
Campbell, JM; Lane, M; Mitchell, M; Nottle, MB; Vassiliev, I	1
Hu, C; Lu, D; Tang, Q; Tang, S; Tian, L; Wang, H; Zeng, Q	1
Constance, JE; Lim, CS; Matissek, KJ; Mossalam, M; Okal, A	1
Ding, H; Du, FT; Huang, Y; Xu, JJ; Zhang, JX	1
Chen, CH; Han, HB; Hu, Q; Khatibi, NH; Li, L; Yan, JH; Yang, XM; Zhou, CM	1
Chen, S; Deng, Y; Jiang, J; Lei, X; Li, X; Liu, Q; Liu, Z; Lu, F; Luo, C; Shi, D; Sun, H; Wang, C; Zhang, H	1
Henshall, DC; Jimenez-Mateos, EM; Matsushima, S; Reynolds, JP; Sano, T; Taki, W	1
Abdelalim, EM; Tooyama, I	1
Chen, CH; Lin, ML; Ong, PL; Yang, JT	1
Bag, J; Bhattacharjee, RB; Zannat, T	1
Anastasia, L; Bergante, S; Conforti, E; Creo, P; Doneda, L; Fania, C; Galli, R; Gelfi, C; Lamorte, G; Mazzoleni, S; Palazzolo, G; Papini, N; Piccoli, M; Roncoroni, L; Scaringi, R; Tettamanti, G; Tringali, C; Venerando, B	1
Abdel-Malek, Z; Chen, J; Chen, S; Cheng, T; Jameson, J; Kadakia, M; Kadekaro, AL; Swope, VB; Yang, J	1
Choi, JY; Ko, JH; Koch, WM; Moon, SJ; Roh, JL; Ryu, CH	1
Benedetti, V; Cincinelli, R; Corna, E; De Cesare, M; Gatti, L; Perego, P; Zaffaroni, N; Zunino, F	1
Feng, X; Guan, L; Hu, Q; Xiao, F; Zeng, M; Zhong, C	1
Cai, BH; Chao, CF; Chen, JY; Chiou, SH; Hsin, IL; Hsu, PC; Lin, HC; Lu, MH; Tao, PL	1
Aplan, PD; Bae, N; Deblasio, TR; Göhring, G; Menendez, S; Nimer, SD; Schlegelberger, B; Xu, H	1
Chen, SL; Chou, MY; Chou, SS; Liao, PH; Pan, YF; Yang, SH	1
Qu, X; Wang, H; Yang, G; Zhang, J; Zhao, W	1
Fujiwara, T; Morimoto, K	1
Hao, Y; Wu, X; Xiao, P; Zhu, X	1
Al-Attas, OS; De Rosas, ET; Ding, S; He, J; He, Q; Hussain, T; Ji, L; Liu, J; Qi, Z; Su, Y; Yu, L	1
Morris, K; Ponville, J; Robbins, D; Zhao, Y	1
Ahn, GO; Ali, ZA; Anderson, DR; Berzin, E; Cheng, H; Cheng, K; Dalman, RL; de Almeida, PE; Downing, KP; Kojima, Y; Kortekaas, KE; Kundu, RK; Kundu, S; Leeper, NJ; Maegdefessel, L; Miller, CL; Owens, GK; Quertermous, M; Quertermous, T; Raiesdana, A; Roberts, SC; Schadt, EE; Spin, JM; Toh, R; Tsao, PS; Wu, JC; Xu, B	1
Derdak, Z; Harb, R; Sousa, A; Villegas, KA; Wands, JR; Wu, AM	1
Aranda, E; Cañas, A; De La Haba-Rodríguez, JR; Fuentes, E; Hernández, V; López-Pedrera, C; López-Sánchez, LM; Muñoz-Castañeda, JR; Rodríguez-Ariza, A; Valverde-Estepa, A	1
Anderson, M; Chan, RJ; Dagher, PC; Hato, T; Kuehl, S; Mai, E; Mang, H; Plotkin, Z; Sutton, TA; Yoshimoto, M	1
Du, WZ; Hao, ZF; Jiang, CL; Lei, XH; Li, XF; Li, YL; Liu, C; Sun, X; Sun, Y; Xin, SY; Zhang, ZR; Zhao, D	1
Kim, HS; Lee, SY; Shin, SJ	1
Panshin, A; Pokroy, R; Tendler, Y; Weisinger, G	1
Nishijima, F; Niwa, T; Shimizu, H; Yisireyili, M	1
Koide, N; Kurokawa, T; Mendjargal, A; Nagata, H; Nonami, T; Odkhuu, E; Yokochi, T	1
Ajayi, A; Langel, Ü; Muñoz-Alarcón, A; Steinhof, A; Ström, AL; Webling, KE; Yu, X	1
Estévez-Calvar, N; Figueras, A; Novoa, B; Romero, A	1
Bian, Y; Chen, Z; Cheng, H; Cook, JD; Coupar, J; Hall, B; Herzog, A; Kulkarni, AB; Mitchell, JB; Sowers, AL; Van Waes, C; Vander Broek, R	1
Chen, P; Shi, D; Wang, Y; Xie, L; Yang, L; Yu, Y; Zhao, X	1
Gu, J; He, W; Kuang, Y; Liu, E; Xing, X	1
Cooley, C; Dobberfuhl, AD; Goldschmeding, R; Higgins, PJ; Meldrum, KK; Overstreet, JM; Patel, S; Samarakoon, R	1
Becanovic, K; Deng, Y; Ehrnhoefer, DE; Engemann, S; Hasholt, L; Hayden, MR; Huynh, KT; Ladha, S; Leavitt, BR; Nguyen, YT; Nielsen, SM; Qiu, X; Skotte, NH	1
Chen, R; Ge, J; Gong, H; Guan, A; Jia, J; Li, B; Qian, S; Sun, A; Yang, C; Ye, Y; Zhang, G; Zou, Y	1
Hsu, A; Tan, BK; Wong, FC; Woo, CC	1
Bu, HQ; Chen, L; Cui, JH; Huang, H; Li, Y; Liu, DL; Wei, WT	1
Greig, NH; Li, Y; Pick, CG; Rachmany, L; Rubovitch, V; Tweedie, D; Wang, JY; Yu, QS	1
Lu, JH; Shi, ZF; Xu, H	1
Guo, SW; Guo, XL; Hu, F; Li, R; Wei, LX; Wu, MC; Ye, F; Zhang, JW; Zhang, SS; Zhao, QD; Zong, C	1
Ariyoshi, M; Fukai, K; Hoshino, A; Ikeda, K; Iwai-Kanai, E; Kaimoto, S; Matoba, S; Ogata, T; Okawa, Y; Uchihashi, M; Ueyama, T	1
Kim, GT; Kim, JI; Kim, YM; Lee, SH	1
He, L; Long, Z; Shi, J; Xie, L; Xie, Y; Yang, Z	1
Rezáčová, M; Vávrová, J	1
Chung, KH; Kim, HR; Oh, SM; Park, CW; Park, YJ; Shin, DY	1
Jia, X; Li, Y; Liu, B; Ye, M; Zhang, X	1
Ciarimboli, G; Gibson, AA; Hermann, E; Janke, LJ; Kosloske, AM; Lancaster, CS; Li, L; Pabla, N; Schlatter, E; Sparreboom, A; Sprowl, JA; Zeeh, D	1
Cheraghpour, M; Ghorbani, A; Homayounfar, R; Jeddi-Tehrani, M; Zand, H	1
Antoniadi, G; Eleftheriadis, T; Liakopoulos, V; Pissas, G; Spanoulis, A; Stefanidis, I	1
Aydin, S; Hampp, S; Ireno, IC; Selivanova, G; Stahl, AI; Troester, MA; Wiehe, RS; Wiesmüller, L	1
Djuzenova, CS; Fiedler, V; Flentje, M; Hartmann, S; Katzer, A; Krohne, G; Memmel, S; Polat, B; Scholz, CJ; Sukhorukov, VL; Zimmermann, H	1
Baldini, A; Caprio, C	1
Hooper, C; Jebelli, J; Pocock, JM	1
Dong, Y; Endo, M; Funamoto, K; Iida, K; Ito, T; Kimura, Y; Sato, N; Sato, T; Velayo, C; Yaegashi, N	1
Culmsee, C; Diemert, S; Ganjam, GK; Neitemeier, S	1
Ben Safta, T; Chouaib, S; Favre, L; Gros, G; Lamendour, L; Mami-Chouaib, F; Martinvalet, D; Thiery, J; Ziani, L	1
Glazova, MV; Grigoreva, YS	1
Han, J; Jiang, J; Jiang, S; Ma, X; Nie, X; Shi, S; Wan, C; Wang, X; Xiao, J; Zhao, J	1
Ishikawa, M; Kanno, S; Kurauchi, K; Tomizawa, A; Yomogida, S	1
Chernigovskaya, EV; Dorofeeva, NA; Glazova, M; Nikitina, LS	1
An, HK; Baik, JS; Kim, CH; Kim, KS; Lee, JW; Lee, YC; Moon, HI; Park, MH; Park, SJ	1
Cho, SG; Gurunathan, S; Jeong, JK; Kang, MH; Kim, JH; Park, C; Park, JK	1
Allavena, G; Corti, A; Del Bello, B; Maellaro, E; Moretti, D; Signorini, C	1
Cao, X; Gu, S; Li, X; Ling, Y; Shen, C; Xie, R	1
Chhor, V; Fleiss, B; Gressens, P; Hagberg, H; Lebon, S; Rajudin, N; Thornton, C	1
Hayano, S; Komatsu, Y; Mishina, Y; Pan, H	1
Ahmed, F; Arai, MA; Fuentes, RG; Ishibashi, M; Sadhu, SK; Toume, K	1
Chu, YH; Greig, NH; Hoffer, BJ; Pick, CG; Tweedie, D; Wang, JY; Yang, LY; Yu, QS	1
Hromas, R; Jaiswal, AS; Jani, J; Law, BK; Narayan, S; Panda, H; Sharma, J	1
Agafonov, VI; Burmina, YV; Chaikovskii, AV; Danilets, MG; Dygai, AM; Minakova, MY; Miroshnichenko, LA; Sherstoboev, EY; Simanina, EV; Trofimova, ES; Udut, EV; Udut, VV; Zhdanov, VV; Zyuz'kov, GN	1
Eddahibi, S; Fadel, E; Humbert, M; Jacquin, S; Londoño-Vallejo, A; Mercier, O; Mignotte, B; Richard, S; Rincheval, V	1
He, W; Li, J; Liao, B; Yang, J	1
Chen, YW; Chou, KM; Harris, RA; Hatahet, Z	1
Bols, NC; Dixon, B; Duncker, BP; Sherry, JP; Yu, X; Zeng, F	1
Ahn, KC; Dunbar, GL; Hall, TC; Learman, CR; MacKenzie, EM; Song, MS; Weaver, CL	1
Chai, X; Dong, FX; Gao, DS; Liu, YP; Zhang, BL; Zhu, S	1
Chaikovskii, AV; Dygai, AM; Gridneva, TD; Minakova, MY; Miroshnichenko, LA; Polyakova, TY; Simanina, EV; Stavrova, LA; Trifonova, OY; Udut, EV; Udut, VV; Zhdanov, VV; Zyuz'kov, GN	1
Cha, BS; Kang, ES; Lee, BW; Lee, WK; Lee, YH; Song, YM	1
Hong, JR; Reshi, L; Wang, HV; Wu, HC; Wu, JL	1
Chang, CK; Chang, YA; Chen, RM; Lin, CJ; Lin, YL; Liu, SH	1
Bian, M; Chen, L; Chen, Q; Jin, H; Lian, N; Lu, C; Shao, J; Wu, L; Zhang, F; Zheng, S	1
Liang, L; Zhang, Z	1
Cai, X; Chen, Q; Du, J; Hou, J; Li, D; Li, Y; Pan, G; Shan, Y; Shen, Q; Shi, X; Wang, L; Wang, X; Zhang, H; Zhang, T; Zhou, T	1
Dong, Y; Guo, X; Li, C; Ni, C; Xie, Z; Zhang, Y	1
Bhatta, N; Chang, L; Jiang, C; Lei, X; Li, C; Liu, D; Sun, Y; Zhang, H; Zhang, P; Zhang, Z	1
Cui, D; Jia, X; Jiang, W; Shang, H; Zhang, X	1
Chen, X; Hughes, ML; Jiang, G; Li, J; Li, L; Li, R; Lu, Z; Qian, F; Sun, Y; Wang, J; Wang, R; Xia, C; Xie, D; Xu, W; Zhang, L	1
Greig, NH; Hoffer, BJ; Hsieh, TH; Huang, YN; Kao, YC; Luo, Y; Tweedie, D; Wang, JY; Yang, LY; Yu, QS	1
Averill-Bates, DA; Glory, A	1
Dong, Z; Hao, J; Li, L; Mei, C; Mei, S; Su, Y; Wei, Q	1
Arellano-Gaytán, M; Contreras-Ochoa, CO; Dimas-González, J; García-Villa, E; Gariglio, P; Lagunas-Martínez, A; López-Arellano, ME; Madrid-Marina, V	1
Chen, J; Li, H; Wang, J; Wang, S; Xiang, X; Zhang, D	1
Ki, SH; Park, EY; Seo, K; Shin, SM	1
Ali, I; Fang, NZ; Hu, DB; Li, ZS; Xu, LJ	1
Giri, RK; Sidhar, H	1
Aghajan, M; Aung Than, T; Hu, H; Huo, Y; Kaplowitz, N; Win, S; Yan, M; Yin, S	1
Feng, D; Hao, S; Jia, K; Liu, B; Lu, C; Xu, F; Yang, Y; Zhu, R	1
Fan, Y; He, J; Huang, Z; Kuang, X; Liu, H; Liu, L; Long, C; Ma, X; Ning, J; Shen, H; Tang, Y; Zhang, Q; Zhou, X	1
Greig, NH; Kim, PP; Lu, T; Luo, Y	1
Fan, J; Jin, F; Liu, E; Liu, Q; Wang, X; Wang, Y; Wu, Y; Zhu, Y	1
Chen, YX; Gao, YS; Guo, YP; Ke, QF; Zhang, CQ; Zhu, R	1
Li, Y; Wang, Y; Yang, L; Yin, D	1
Frick, T; Glas, M; Grandgirard, D; Haenggi, M; Jakob, SM; Leib, SL; Putzu, A; Springe, D; Takala, J; Zuercher, P	1
Ganeshan, L; Jin, XL; O'Neill, C	1
Baldari, S; Cirone, M; D'Orazi, G; Garufi, A; Pistritto, G; Toietta, G	1
Dai, X; Geng, F; Li, M	1
Chen, S; Du, W; Lin, W; Ni, Z; Zhao, Y; Zhao, Z	1
Geng, P; Li, G; Li, L; Liu, Y; Song, H; Yang, Y	1
Niu, Z; Wang, L; Wu, S; Zheng, M	1
Cai, L; Damodaran, C; Feng, A; Gu, J; Guo, H; Keller, BB; Liang, Y; Liu, Q; Tan, Y; Wang, S; Zhang, C; Zhang, Z	1
Acharya, A; Chaudhari, U; Hengstler, JG; Hescheler, J; Nemade, H; Papadopoulos, S; Sachinidis, A	1
Greig, NH; Huang, YN; Lai, CC; Wang, JY; Wang, YC; Yang, LY	1
Agarwal, SK; Choudhary, A; Rai, KM; Sable, A; Sawant, SV; Yadav, VK	1
Bin, BH; Cho, EG; Choi, SY; Kim, W; Lee, E; Lee, TR	1
Abe, K; Kuno, A; Miki, T; Miura, T; Steenbergen, C; Tanno, M; Yano, T	1
Barnett, A; Casey, A; Greig, NH; Jin, Y; Kim, P; Luo, Y; Scerba, M; Selman, W; Turcato, F	1
Jing, L; Xie, YL; Zhang, B	1
Dai, Y; Feng, X; Guan, Y; Guo, J; Jiang, W; Jin, F; Li, G; Li, W; Liu, G; Liu, J; Lu, Y; Shi, C; Xu, H; Zeng, L; Zhao, X; Zhou, W; Zhu, Y	1
Fu, W; Liu, Y; Sun, C; Yin, H	1
Chabasse, C; Hoofnagle, M; Mukhopadhyay, S; Pfaff, MJ; Sarkar, R	1
Sui, S; Yin, X; Zhang, B	1
Dong, N; Ren, C; Wu, TT; Xu, CF; Yao, YM; Zhang, H	1
Bao, Y; Guo, J; Pu, Z; Sun, W; Tang, Q; Wang, J; Wang, Q	1
Johnson, ACM; Zager, RA	1
Huang, W; Jia, Y; Jiang, Z; Liang, W; Ma, F; Tian, Y; Wu, H; Wu, J	1
Li, Q; Wang, L; Xu, X; Xu, Y; Yang, F; Yin, Z; Zhang, Q	1
Bae, E; Chen, H; Chen, YH; Greig, NH; Harvey, BK; Wang, Y; Yu, SJ	1
Fang, W; Guan, B; Lin, J; Liu, F; Liu, L; Luo, Z; Yang, A; Zuo, W	1
Makino, K; Nii, T; Tabata, Y	1
Ahmed, A; Bezzerides, VJ; Cho, A; Escalante, GO; Garbern, JC; Helman, A; Kim, SL; Lee, RT; MacQueen, L; Melton, DA; Ogurlu, R; Parker, KK; Sarikhani, M; Sereda, R; Zimmerman, JF	1
Chang, KH; Chiang, YH; Greig, NH; Hoffer, BJ; Jung, YJ; Miller, JP; Tweedie, D; Wang, JY; Yang, LY	1
Chen, Y; Huang, H; Li, H; Liu, B; Lu, C; Qi, W; Yang, Z; Zhang, L; Zhang, W	1
Aytatli, A; Barlak, N; Capik, O; Karatas, OF; Kilic, A; Sanli, F	1
Peuget, S; Selivanova, G; Singh, M; Zhu, J	1
Cheng, H; He, W; He, Y; Jie, Q; Li, L; Shen, W; Sun, D; Tan, J; Tao, W; Yang, Y; Zhang, F; Zhu, W	1
Cheng, J; Li, Q; Liang, H; Lin, Z; Lu, Y; Wang, W; Xie, X; Zhang, T	1
Desaphy, JF; Lentini, G; Majoral, JP; Mignani, S	1
Chai, R; Chen, P; Cheng, C; Duan, X; Gao, Y; Liu, D; Pang, X; Qian, F; Sun, C; Sun, F; Wei, G; Wu, H; Yang, T; Zhang, L; Zhang, R	1
Huang, C; Lam, KT; Lau, YL; Liu, M; Liu, Y; Ni, K; Peiris, M; Perlman, S; Teng, O; Tu, W; Wen, L; Wu, WF; Yang, J; Yen, HL; Zheng, J	1
Atali, S; Dorandish, S; Evans, HG; Guthrie, J; Heyl, D; Price, D; Sendo, S; Thompson, C; Williams, A	1
Liu, Y; Luo, H; Sang, M; Sun, X; Xu, H; Xu, M; Xu, Y; Zeng, L; Zhang, F; Zhang, Z	1
Xia, S	1
Agafonov, VI; Chaikovskii, AV; Danilets, MG; Miroshnichenko, LA; Polyakova, TY; Simanina, EV; Stavrova, LA; Zhdanov, VV; Zyuz'kov, GN	1
Cook, JK; Lee, KY; Liu, DC; Lizarazo, S; Tsai, NP	1
Allison, TF; Buth, JE; Ferando, I; Fotion, NN; Gandal, MJ; Golshani, P; Kurdian, A; Lowry, WE; Miranda, OA; Mitchell, S; Mody, I; Novitch, BG; Parent, JM; Plath, K; Samarasinghe, RA; Watanabe, M	1
Li, J; Meng, Y; Sun, Y; Wu, X; Yan, R; Zou, H	1
Jiejun, W; Lisha, Z; Niansong, W; Qin, X; Yuqiang, C	1
Chen, Z; Cui, L; Li, H; Li, X; Liang, Y; Liu, S; Liu, Z; Wang, Z; Xu, L; Zhang, Y	1
Al-Sudani, BT; Jalil, HA; Jasim, GA	1

Reviews

7 review(s) available for pifithrin and toluene

Article	Year
Suppression of p53: a new approach to overcome side effects of antitumor therapy. Biochemistry. Biokhimiia, 2000, Volume: 65, Issue:1 Topics: Animals; Antineoplastic Agents; Apoptosis; Benzothiazoles; Gene Expression Regulation, Neoplastic; Genes, Tumor Suppressor; Humans; Mice; Mice, Transgenic; Neoplasms; Thiazoles; Toluene; Tumor Cells, Cultured; Tumor Suppressor Protein p53	2000
Resistance to apoptosis in prostate cancer cells. Molecular urology, 2000,Fall, Volume: 4, Issue:3 Topics: Androgen Antagonists; Androgens; Apoptosis; Benzothiazoles; Caspases; DNA Repair; Drug Resistance, Neoplasm; Enzyme Activation; Humans; Male; Micrococcus; Prostatic Neoplasms; Thiazoles; Toluene; Tumor Suppressor Protein p53	2000
Prospective therapeutic applications of p53 inhibitors. Biochemical and biophysical research communications, 2005, Jun-10, Volume: 331, Issue:3 Topics: Animals; Antineoplastic Agents; Apoptosis; Benzothiazoles; Drug Synergism; Humans; Neurodegenerative Diseases; Neuroprotective Agents; Radiation-Protective Agents; Thiazoles; Toluene; Tumor Suppressor Protein p53	2005
Intestinal mucositis: the role of the Bcl-2 family, p53 and caspases in chemotherapy-induced damage. Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2006, Volume: 14, Issue:7 Topics: Animals; Antineoplastic Agents; Apoptosis; Benzothiazoles; Caspases; Cell Proliferation; Humans; Intestinal Mucosa; Mucositis; Proto-Oncogene Proteins c-bcl-2; Radiation-Protective Agents; Stem Cells; Toluene; Tumor Suppressor Protein p53	2006
Dangerous habits of a security guard: the two faces of p53 as a drug target. Human molecular genetics, 2007, Apr-15, Volume: 16 Spec No 1 Topics: Animals; Apoptosis; Benzothiazoles; Gene Expression Regulation; Genes, p53; Humans; Neoplasms; Toluene; Tumor Suppressor Protein p53	2007
Importance of proapoptotic protein PUMA in cell radioresistance. Folia biologica, 2014, Volume: 60, Issue:2 Topics: Animals; Apoptosis; Apoptosis Regulatory Proteins; Benzothiazoles; Cell Cycle Checkpoints; Mice; Proto-Oncogene Proteins; Toluene; Tumor Suppressor Proteins	2014
From Riluzole to Dexpramipexole via Substituted-Benzothiazole Derivatives for Amyotrophic Lateral Sclerosis Disease Treatment: Case Studies. Molecules (Basel, Switzerland), 2020, Jul-22, Volume: 25, Issue:15 Topics: Amyotrophic Lateral Sclerosis; Animals; Benzothiazoles; Clinical Trials as Topic; Drug Approval; Drug Evaluation, Preclinical; Humans; Neuroprotective Agents; Pramipexole; Riluzole; Small Molecule Libraries; Toluene; Treatment Outcome	2020

Other Studies

352 other study(ies) available for pifithrin and toluene

Article	Year
A chemical inhibitor of p53 that protects mice from the side effects of cancer therapy. Science (New York, N.Y.), 1999, Sep-10, Volume: 285, Issue:5434 Topics: Animals; Antineoplastic Agents; Apoptosis; Benzothiazoles; Cell Division; Cell Line; Cell Nucleus; Cytoplasm; DNA; DNA Damage; G2 Phase; Gamma Rays; Humans; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Nude; Neoplasms; Radiation Tolerance; Thiazoles; Time Factors; Toluene; Tumor Cells, Cultured; Tumor Suppressor Protein p53; Ultraviolet Rays	1999
Cancer research. A new way to combat therapy side effects. Science (New York, N.Y.), 1999, Sep-10, Volume: 285, Issue:5434 Topics: Animals; Antineoplastic Agents; Apoptosis; Benzothiazoles; Cell Division; Cells, Cultured; Drug Evaluation, Preclinical; Gamma Rays; Humans; Mice; Neoplasms; Radiation Dosage; Radiation Tolerance; Thiazoles; Toluene; Tumor Suppressor Protein p53	1999
[PFTalpha, guardian of the sick?]. Bulletin du cancer, 1999, Volume: 86, Issue:11 Topics: Animals; Antineoplastic Agents; Apoptosis; Benzothiazoles; Cell Cycle; DNA Damage; DNA Repair; DNA, Neoplasm; Mice; Mutation; Thiazoles; Toluene; Tumor Suppressor Protein p53	1999
[A chemical inhibitor of p53 that protects mice from the side effects of cancer treatment]. Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al], 2000, Volume: 176, Issue:2 Topics: Animals; Antineoplastic Agents; Benzothiazoles; Combined Modality Therapy; Drug Evaluation, Preclinical; Mice; Neoplasms, Experimental; Radiotherapy; Thiazoles; Toluene; Tumor Cells, Cultured; Tumor Suppressor Protein p53	2000
A synthetic inhibitor of p53 protects neurons against death induced by ischemic and excitotoxic insults, and amyloid beta-peptide. Journal of neurochemistry, 2001, Volume: 77, Issue:1 Topics: Amyloid beta-Peptides; Animals; Antineoplastic Agents; Benzothiazoles; Brain Ischemia; Caspase 3; Caspases; Cell Death; Cell Survival; Cells, Cultured; Disease Models, Animal; DNA; Dose-Response Relationship, Drug; Glutamic Acid; Kainic Acid; Mice; Mice, Inbred C57BL; Mitochondria; Neurons; Prodrugs; Rats; Rats, Sprague-Dawley; Seizures; Thiazoles; Toluene; Tumor Suppressor Protein p53	2001
Neurons are protected from excitotoxic death by p53 antisense oligonucleotides delivered in anionic liposomes. The Journal of biological chemistry, 2001, Aug-24, Volume: 276, Issue:34 Topics: Animals; Anions; Base Sequence; Benzothiazoles; Cell Death; Cell Line; Cricetinae; DNA Primers; Drug Carriers; Excitatory Amino Acid Antagonists; Glutamic Acid; Humans; Liposomes; Neurons; Neuroprotective Agents; Oligonucleotides, Antisense; Osmolar Concentration; Rats; Thiazoles; Toluene; Tumor Suppressor Protein p53	2001
p21 Waf1/Cip1 can protect human colon carcinoma cells against p53-dependent and p53-independent apoptosis induced by natural chemopreventive and therapeutic agents. Oncogene, 2001, Jun-07, Volume: 20, Issue:26 Topics: Adenocarcinoma; Alleles; Amino Acid Chloromethyl Ketones; Anticarcinogenic Agents; Antineoplastic Agents; Apoptosis; Benzothiazoles; Butyrates; Cisplatin; Colonic Neoplasms; Cyclin-Dependent Kinase Inhibitor p21; Cyclins; Cysteine Proteinase Inhibitors; Demecolcine; Doxorubicin; Drug Resistance, Neoplasm; Etoposide; Fluorouracil; Gene Expression Regulation, Neoplastic; Genes, p53; Humans; Intracellular Membranes; Membrane Potentials; Mitochondria; Neoplasm Proteins; Recombination, Genetic; Resveratrol; Stilbenes; Thiazoles; Toluene; Tumor Cells, Cultured; Tumor Suppressor Protein p53	2001
Doxorubicin induces apoptosis and CD95 gene expression in human primary endothelial cells through a p53-dependent mechanism. The Journal of biological chemistry, 2002, Mar-29, Volume: 277, Issue:13 Topics: Apoptosis; Base Sequence; Benzothiazoles; Cell Division; Cells, Cultured; DNA Primers; Doxorubicin; Endothelium, Vascular; fas Receptor; Fluorescent Antibody Technique; Gene Expression Regulation; Humans; Promoter Regions, Genetic; Thiazoles; Toluene; Tumor Suppressor Protein p53	2002
Sodium butyrate induces P53-independent, Fas-mediated apoptosis in MCF-7 human breast cancer cells. British journal of pharmacology, 2002, Volume: 135, Issue:1 Topics: Apoptosis; bcl-2-Associated X Protein; Benzothiazoles; Blotting, Western; Breast Neoplasms; Butyrates; Caspase Inhibitors; Cell Cycle; Cell Division; Fas Ligand Protein; fas Receptor; Humans; Membrane Glycoproteins; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Signal Transduction; Thiazoles; Toluene; Tumor Cells, Cultured; Tumor Suppressor Protein p53	2002
Regulation of functional nuclear pore size in fibroblasts. Journal of cell science, 2001, Volume: 114, Issue:Pt 24 Topics: 3T3 Cells; Active Transport, Cell Nucleus; Animals; Benzothiazoles; Cycloheximide; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Diffusion; Fibroblasts; Gold Colloid; Leupeptins; Mice; Multienzyme Complexes; Nuclear Localization Signals; Nuclear Pore; Proteasome Endopeptidase Complex; Thiazoles; Toluene; Tumor Suppressor Protein p53	2001
Pifithrin-alpha, an inhibitor of p53, enhances the genetic instability induced by etoposide (VP16) in human lymphoblastoid cells treated in vitro. Mutation research, 2002, Feb-20, Volume: 499, Issue:2 Topics: Antineoplastic Agents, Phytogenic; Benzothiazoles; Cell Cycle; Cell Survival; Chromosome Aberrations; DNA Fragmentation; Dose-Response Relationship, Drug; Drug Synergism; Etoposide; Flow Cytometry; Humans; In Vitro Techniques; Karyotyping; Lymphocytes; Thiazoles; Time Factors; Toluene; Tumor Cells, Cultured; Tumor Suppressor Protein p53	2002
Rescue of neural tube defects in Pax-3-deficient embryos by p53 loss of function: implications for Pax-3- dependent development and tumorigenesis. Genes & development, 2002, Mar-15, Volume: 16, Issue:6 Topics: Animals; Apoptosis; Benzothiazoles; Blotting, Western; DNA-Binding Proteins; Down-Regulation; Genes, p53; Genotype; Heterozygote; In Situ Nick-End Labeling; Mice; Mice, Inbred C57BL; Neural Crest; Neural Tube Defects; Paired Box Transcription Factors; PAX3 Transcription Factor; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Thiazoles; Time Factors; Toluene; Transcription Factors; Transcription, Genetic; Tumor Suppressor Protein p53	2002
Pifithrin-alpha (PFT-alpha) caused differential protection of rat liver cells and HepG2 cell line in response to the selective cytotoxicity of arsenic and cadmium. Biomedical sciences instrumentation, 2002, Volume: 38 Topics: Animals; Arsenic Trioxide; Arsenicals; Benzothiazoles; Cadmium Chloride; Cell Line; Cytoprotection; Dose-Response Relationship, Drug; Liver; Oxides; Rats; Rats, Wistar; Regression Analysis; Thiazoles; Toluene	2002
p53 May positively regulate hepatocyte proliferation in rats. Hepatology (Baltimore, Md.), 2002, Volume: 36, Issue:2 Topics: Animals; Antimetabolites; Benzothiazoles; Bromodeoxyuridine; Cell Division; Cells, Cultured; Hepatectomy; Hepatocyte Growth Factor; Hepatocytes; Male; Oligonucleotides, Antisense; Rats; Rats, Sprague-Dawley; Thiazoles; Toluene; Transforming Growth Factor alpha; Tumor Suppressor Protein p53	2002
Acceleration of cutaneous wound healing by transient p53 inhibition. Laboratory investigation; a journal of technical methods and pathology, 2002, Volume: 82, Issue:8 Topics: Animals; Benzothiazoles; Cell Division; Female; Male; Mice; Skin; Thiazoles; Toluene; Tumor Suppressor Protein p53; Wound Healing	2002
Augmented antitumour effects of combination therapy with TNP-470 and chemoimmunotherapy in mice. Journal of cancer research and clinical oncology, 2002, Volume: 128, Issue:8 Topics: Angiogenesis Inhibitors; Animals; Antineoplastic Agents; Benzothiazoles; Blotting, Western; Cell Division; Cisplatin; Colonic Neoplasms; Cyclin-Dependent Kinase Inhibitor p21; Cyclins; Cyclohexanes; Drug Synergism; Drug Therapy, Combination; Flow Cytometry; Immunotherapy; Interferon-gamma; Interleukin-12; Melanoma, Experimental; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Inbred DBA; Neovascularization, Pathologic; O-(Chloroacetylcarbamoyl)fumagillol; Sesquiterpenes; Tetrazolium Salts; Thiazoles; Toluene; Tumor Suppressor Protein p53	2002
p53 inhibitors preserve dopamine neurons and motor function in experimental parkinsonism. Annals of neurology, 2002, Volume: 52, Issue:5 Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Apoptosis; bcl-2-Associated X Protein; Behavior, Animal; Benzothiazoles; Dopamine; Dopamine Agents; Male; Mice; Mice, Inbred C57BL; Motor Activity; Neurons; Neuroprotective Agents; Parkinsonian Disorders; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Thiazoles; Toluene; Tumor Suppressor Protein p53	2002
CD40-mediated apoptosis in murine B-lymphoma lines containing mutated p53. Experimental cell research, 2002, Nov-01, Volume: 280, Issue:2 Topics: Animals; Apoptosis; B-Lymphocytes; Benzothiazoles; CD40 Antigens; DNA-Binding Proteins; Fas Ligand Protein; fas Receptor; Flow Cytometry; Genes, Reporter; I-kappa B Proteins; Lymphoma, B-Cell; Membrane Glycoproteins; Mice; NF-kappa B; NF-KappaB Inhibitor alpha; Point Mutation; Thiazoles; Toluene; Tumor Cells, Cultured; Tumor Suppressor Protein p53	2002
P53 mediates the apoptotic response to GTP depletion after renal ischemia-reperfusion: protective role of a p53 inhibitor. Journal of the American Society of Nephrology : JASN, 2003, Volume: 14, Issue:1 Topics: Animals; Apoptosis; bcl-2-Associated X Protein; Benzothiazoles; Cyclin-Dependent Kinase Inhibitor p21; Cyclins; Guanosine; Guanosine Triphosphate; Kidney; Kidney Cortex; Kidney Medulla; LLC-PK1 Cells; Male; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Rats; Rats, Sprague-Dawley; Renal Circulation; Reperfusion Injury; Swine; Thiazoles; Tissue Distribution; Toluene; Tumor Suppressor Protein p53	2003
Suppression of high-fidelity double-strand break repair in mammalian chromosomes by pifithrin-alpha, a chemical inhibitor of p53. DNA repair, 2003, Jan-02, Volume: 2, Issue:1 Topics: Animals; Benzothiazoles; Cell Line; DNA Repair; Fibroblasts; In Vitro Techniques; Mice; Thiazoles; Toluene; Tumor Suppressor Protein p53	2003
Polymerase eta and p53 jointly regulate cell survival, apoptosis and Mre11 recombination during S phase checkpoint arrest after UV irradiation. DNA repair, 2002, Jan-22, Volume: 1, Issue:1 Topics: Acid Anhydride Hydrolases; Apoptosis; Benzothiazoles; beta-Galactosidase; Blotting, Western; Cell Cycle Proteins; Cell Line, Transformed; Cell Survival; DNA Repair Enzymes; DNA Replication; DNA-Binding Proteins; DNA-Directed DNA Polymerase; Fibroblasts; Humans; MRE11 Homologue Protein; Nuclear Proteins; Oncogene Proteins, Viral; Recombination, Genetic; S Phase; Simian virus 40; Thiazoles; Toluene; Tumor Suppressor Protein p53; Ultraviolet Rays	2002
The C-terminal fragment of presenilin 2 triggers p53-mediated staurosporine-induced apoptosis, a function independent of the presenilinase-derived N-terminal counterpart. The Journal of biological chemistry, 2003, Apr-04, Volume: 278, Issue:14 Topics: Animals; Apoptosis; Benzothiazoles; Caspase 3; Caspases; Cells, Cultured; Dimerization; Enzyme Inhibitors; Fibroblasts; Gene Expression; Humans; Kidney; Membrane Proteins; Mice; Peptide Fragments; Phenotype; Presenilin-2; Protein Structure, Tertiary; Staurosporine; Thiazoles; Toluene; Tumor Suppressor Protein p53	2003
p53 inhibitor pifithrin alpha can suppress heat shock and glucocorticoid signaling pathways. The Journal of biological chemistry, 2003, May-02, Volume: 278, Issue:18 Topics: Animals; Benzothiazoles; DNA-Binding Proteins; Glucocorticoids; Heat Shock Transcription Factors; Heat-Shock Response; Mice; NF-kappa B; Receptors, Glucocorticoid; Signal Transduction; Thiazoles; Toluene; Transcription Factors; Tumor Suppressor Protein p53	2003
Inhibition of p53 protects liver tissue against endotoxin-induced apoptotic and necrotic cell death. FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2003, Volume: 17, Issue:6 Topics: Animals; Apoptosis; Benzothiazoles; Blotting, Western; Caspase 3; Caspases; Cell Nucleus; Cytoplasm; Female; Immunohistochemistry; Lipopolysaccharides; Liver; Male; Microscopy, Fluorescence; Necrosis; NF-kappa B; Rats; Rats, Sprague-Dawley; Thiazoles; Toluene; Transaminases; Tumor Suppressor Protein p53	2003
p53 inactivation leads to impaired motor synchronization in mice. The European journal of neuroscience, 2003, Volume: 17, Issue:10 Topics: Animals; Benzothiazoles; Cerebellum; Lameness, Animal; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Motor Activity; Motor Neurons; Muscle Fibers, Fast-Twitch; Muscle, Skeletal; Neuromuscular Junction; Olivary Nucleus; Organ Culture Techniques; Thiazoles; Toluene; Tumor Suppressor Protein p53; Walking	2003
Multiple signaling events in amyloid beta-induced, oxidative stress-dependent neuronal apoptosis. Free radical biology & medicine, 2003, Jul-01, Volume: 35, Issue:1 Topics: Acetylcysteine; alpha-Tocopherol; Amyloid beta-Peptides; Apoptosis; bcl-2-Associated X Protein; Benzothiazoles; Caspase 3; Caspases; Cell Differentiation; Cytochromes c; Enzyme Activation; Enzyme Inhibitors; Humans; Hydrogen Peroxide; JNK Mitogen-Activated Protein Kinases; MAP Kinase Kinase 4; Mitochondria; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Neuroblastoma; Oxidative Stress; p38 Mitogen-Activated Protein Kinases; Peptide Fragments; Poly(ADP-ribose) Polymerases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Thiazoles; Toluene; Tumor Cells, Cultured; Tumor Suppressor Protein p53	2003
p53 is present in synapses where it mediates mitochondrial dysfunction and synaptic degeneration in response to DNA damage, and oxidative and excitotoxic insults. Neuromolecular medicine, 2003, Volume: 3, Issue:3 Topics: Animals; Benzothiazoles; Brain; Cells, Cultured; DNA Damage; Etoposide; Membrane Potentials; Mice; Mitochondria; Neurodegenerative Diseases; Neuroprotective Agents; Neurotoxins; Nucleic Acid Synthesis Inhibitors; Oxidative Stress; Phosphorylation; Presynaptic Terminals; Reactive Oxygen Species; Synapsins; Synaptosomes; Thiazoles; Toluene; Tumor Suppressor Protein p53	2003
Pifithrin-alpha suppresses p53 and protects cochlear and vestibular hair cells from cisplatin-induced apoptosis. Neuroscience, 2003, Volume: 120, Issue:1 Topics: Animals; Apoptosis; Benzothiazoles; Cisplatin; Cochlea; Dose-Response Relationship, Drug; Hair Cells, Vestibular; Organ Culture Techniques; Rats; Rats, Inbred F344; Thiazoles; Toluene; Tumor Suppressor Protein p53	2003
Induction of apoptosis by depletion of DNA topoisomerase IIalpha in mammalian cells. Biochemical and biophysical research communications, 2003, Jul-25, Volume: 307, Issue:2 Topics: Animals; Antigens, Neoplasm; Antineoplastic Agents; Apoptosis; Benzothiazoles; Caspases; Cell Nucleus; Diketopiperazines; DNA Topoisomerases, Type II; DNA-Binding Proteins; Embryo, Mammalian; Enzyme Activation; Fluorescent Dyes; HeLa Cells; Humans; In Situ Nick-End Labeling; Mice; Mice, Knockout; Nocodazole; Piperazines; RNA, Small Interfering; Thiazoles; Toluene; Topoisomerase II Inhibitors	2003
Pifithrin-alpha promotes p53-mediated apoptosis in JB6 cells. Molecular carcinogenesis, 2003, Volume: 37, Issue:3 Topics: Animals; Antineoplastic Agents; Apoptosis; Benzothiazoles; Blotting, Western; Cells, Cultured; Doxorubicin; Gene Expression Regulation; Genes, Dominant; JNK Mitogen-Activated Protein Kinases; Mice; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Precipitin Tests; Signal Transduction; Skin; Thiazoles; Toluene; Transcriptional Activation; Tumor Suppressor Protein p53; Ultraviolet Rays	2003
Inhibition of p53, p21 and Bax by pifithrin-alpha does not affect UV induced apoptotic response in CS-B cells. DNA repair, 2003, Aug-12, Volume: 2, Issue:8 Topics: Apoptosis; bcl-2-Associated X Protein; Benzothiazoles; Cells, Cultured; Cockayne Syndrome; Electrophoresis, Polyacrylamide Gel; Fluorescent Antibody Technique; Humans; Immunoblotting; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; rho GTP-Binding Proteins; Thiazoles; Toluene; Transcriptional Activation; Tumor Suppressor Protein p53; Ultraviolet Rays	2003
Involvement of p53 in specific anti-neuroectodermal tumor activity of aloe-emodin. International journal of cancer, 2003, Oct-10, Volume: 106, Issue:6 Topics: Anthraquinones; Apoptosis; Benzothiazoles; Blotting, Western; Caspases; Cell Cycle; Child, Preschool; Cytochromes c; DNA Primers; DNA Topoisomerases, Type II; DNA, Neoplasm; Emodin; Enzyme Inhibitors; Gene Expression Regulation, Neoplastic; Genes, bcl-2; Humans; Male; Microscopy, Immunoelectron; Mitochondria; Mutation; Neuroectodermal Tumors; Poly(ADP-ribose) Polymerases; Protein Transport; Reverse Transcriptase Polymerase Chain Reaction; Thiazoles; Toluene; Tumor Cells, Cultured; Tumor Suppressor Protein p53	2003
The p53-inhibitor pifithrin-alpha inhibits firefly luciferase activity in vivo and in vitro. BMC molecular biology, 2003, Sep-11, Volume: 4 Topics: Animals; Benzothiazoles; Cell Line; Cells, Cultured; Chloramphenicol O-Acetyltransferase; Coleoptera; Genes, Reporter; Humans; Luciferases; Plasmids; Thiazoles; Toluene; Transcription, Genetic; Tumor Suppressor Protein p53	2003
Reciprocal inhibition of p53 and nuclear factor-kappaB transcriptional activities determines cell survival or death in neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2003, Sep-17, Volume: 23, Issue:24 Topics: Acetyltransferases; Animals; Benzothiazoles; Brain Ischemia; Cell Cycle Proteins; Cell Death; Cell Hypoxia; Cell Survival; Cells, Cultured; Dose-Response Relationship, Drug; Female; Genes, Reporter; Glucose; Histone Acetyltransferases; Homocysteine; Male; Mice; Mice, Transgenic; Neurons; Neuroprotective Agents; NF-kappa B; p300-CBP Transcription Factors; Rats; Rats, Sprague-Dawley; Rats, Wistar; Signal Transduction; Stress, Physiological; Thiazoles; Toluene; Transcription Factors; Transcription, Genetic; Tumor Suppressor Protein p53	2003
p53 down-regulation: a new molecular mechanism involved in ischaemic preconditioning. FEBS letters, 2003, Dec-04, Volume: 555, Issue:2 Topics: Androstadienes; Animals; Benzothiazoles; Blotting, Northern; Down-Regulation; Enzyme Inhibitors; Ischemic Preconditioning, Myocardial; Male; Myocardial Infarction; Myocardial Ischemia; Myocardial Reperfusion; Nuclear Proteins; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Precipitin Tests; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-mdm2; Rats; Rats, Sprague-Dawley; Thiazoles; Toluene; Tumor Suppressor Protein p53; Wortmannin	2003
Oxidative stress induces p53-mediated apoptosis in glia: p53 transcription-independent way to die. Journal of neuroscience research, 2004, Jan-01, Volume: 75, Issue:1 Topics: Amino Acid Chloromethyl Ketones; Animals; Apoptosis; Astrocytes; Benzothiazoles; Blotting, Northern; Cell Survival; Cells, Cultured; Cytochromes c; Embryo, Mammalian; Fluorescent Antibody Technique; Genes, bcl-2; Hydrogen Peroxide; Microscopy, Confocal; Mitochondria; Models, Biological; Neuroprotective Agents; Nuclear Proteins; Nucleosomes; Oxidants; Oxidative Stress; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-mdm2; Rats; Recovery of Function; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Thiazoles; Time Factors; Toluene; Tumor Suppressor Protein p53	2004
p53-mediated mitochondrial dysfunction by proteasome inhibition in dopaminergic SH-SY5Y cells. Neuroscience letters, 2004, Jan-16, Volume: 354, Issue:3 Topics: bcl-2-Associated X Protein; Benzimidazoles; Benzothiazoles; Blotting, Western; Carbocyanines; Cell Death; Cell Line, Tumor; Cell Survival; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Dopamine; Dose-Response Relationship, Drug; Drug Interactions; Fluorescent Antibody Technique; Humans; Leupeptins; Membrane Potentials; Mitochondria; Multienzyme Complexes; Neuroblastoma; Proteasome Endopeptidase Complex; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Thiazoles; Time Factors; Toluene; Tumor Suppressor Protein p53	2004
Pifithrin-alpha protects against doxorubicin-induced apoptosis and acute cardiotoxicity in mice. American journal of physiology. Heart and circulatory physiology, 2004, Volume: 286, Issue:3 Topics: Acute Disease; Animals; Antibiotics, Antineoplastic; Apoptosis; Benzothiazoles; Cell Line, Tumor; Creatine Kinase; Doxorubicin; Gene Expression; Heart; Heart Diseases; Mice; Mice, Inbred ICR; Myocardium; Thiazoles; Toluene; Tumor Suppressor Protein p53	2004
Apoptotic mitochondrial dysfunction induced by benzo(a)pyrene in liver epithelial cells: role of p53 and pHi changes. Annals of the New York Academy of Sciences, 2003, Volume: 1010 Topics: Animals; Apoptosis; Benzo(a)pyrene; Benzothiazoles; Bongkrekic Acid; Cell Line; Epithelial Cells; Guanidines; Hydrogen-Ion Concentration; Liver; Mitochondria; Rats; Sulfones; Thiazoles; Toluene; Tumor Suppressor Protein p53	2003
Dual effect of p53 on radiation sensitivity in vivo: p53 promotes hematopoietic injury, but protects from gastro-intestinal syndrome in mice. Oncogene, 2004, Apr-22, Volume: 23, Issue:19 Topics: Animals; Apoptosis; Benzothiazoles; Digestive System; Hematopoiesis; Mice; Mice, Inbred C57BL; Radiation Tolerance; Thiazoles; Toluene; Tumor Suppressor Protein p53	2004
The role of p53-induced apoptosis in cerebral ischemia: effects of the p53 inhibitor pifithrin alpha. Experimental neurology, 2004, Volume: 187, Issue:2 Topics: Animals; Apoptosis; Benzothiazoles; Blotting, Western; Brain; Brain Ischemia; Cell Count; Disability Evaluation; Disease Models, Animal; Dose-Response Relationship, Drug; Immunohistochemistry; Male; Motor Activity; Neuroprotective Agents; Rats; Rats, Sprague-Dawley; Thiazoles; Time Factors; Toluene; Tumor Suppressor Protein p53	2004
Pifithrin-alpha inhibits p53 signaling after interaction of the tumor suppressor protein with hsp90 and its nuclear translocation. The Journal of biological chemistry, 2004, Jul-16, Volume: 279, Issue:29 Topics: Active Transport, Cell Nucleus; Animals; Benzothiazoles; Cell Line; Cell Nucleus; Chloramphenicol O-Acetyltransferase; Cyclin-Dependent Kinase Inhibitor p21; Cyclins; Dexamethasone; Dose-Response Relationship, Drug; HeLa Cells; HSP70 Heat-Shock Proteins; HSP90 Heat-Shock Proteins; Humans; Immunophilins; Mice; Protein Binding; Signal Transduction; Thiazoles; Time Factors; Toluene; Transcription, Genetic; Tumor Suppressor Protein p53; Tumor Suppressor Proteins	2004
Improvement of rat liver graft quality by pifithrin-alpha-mediated inhibition of hepatocyte necrapoptosis. Hepatology (Baltimore, Md.), 2004, Volume: 39, Issue:6 Topics: Animals; Apoptosis; Benzothiazoles; Caspase 3; Caspases; Female; Hepatocytes; Immunohistochemistry; Liver; Liver Transplantation; Male; Necrosis; Rats; Rats, Sprague-Dawley; Thiazoles; Toluene	2004
Selenite-induced p53 Ser-15 phosphorylation and caspase-mediated apoptosis in LNCaP human prostate cancer cells. Molecular cancer therapeutics, 2004, Volume: 3, Issue:7 Topics: Amino Acid Chloromethyl Ketones; Apoptosis; Benzothiazoles; Caspase Inhibitors; Caspases; Cell Line, Tumor; Enzyme Activation; Humans; Male; Phosphorylation; Poly(ADP-ribose) Polymerases; Prostatic Neoplasms; Serine; Sodium Selenite; Thiazoles; Toluene; Tumor Suppressor Protein p53	2004
Role of p53 in cisplatin-induced tubular cell apoptosis: dependence on p53 transcriptional activity. American journal of physiology. Renal physiology, 2004, Volume: 287, Issue:6 Topics: Amino Acid Chloromethyl Ketones; Animals; Apoptosis; Benzothiazoles; Caspase Inhibitors; Caspases; Cell Line; Cisplatin; Enzyme Inhibitors; Genes, p53; Kidney Tubules, Proximal; Mutation; Phosphorylation; Proto-Oncogene Proteins c-bcl-2; Rats; Thiazoles; Toluene; Transcription, Genetic; Transfection; Tumor Suppressor Protein p53	2004
Calcitriol-induced prostate-derived factor: autocrine control of prostate cancer cell growth. International journal of cancer, 2004, Dec-20, Volume: 112, Issue:6 Topics: Antineoplastic Agents; Benzothiazoles; Bone Morphogenetic Proteins; Calcitriol; Calcium Channel Agonists; Cell Line, Tumor; Cell Proliferation; Dactinomycin; Dihydrotestosterone; DNA, Complementary; DNA, Neoplasm; Dose-Response Relationship, Drug; Gene Expression Regulation, Neoplastic; Growth Differentiation Factor 15; Humans; Male; Membrane Proteins; Prostatic Neoplasms; Recombinant Proteins; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; RNA, Neoplasm; Thiazoles; Toluene; Vanadates	2004
Survivin and p53 modulate quercetin-induced cell growth inhibition and apoptosis in human lung carcinoma cells. The Journal of biological chemistry, 2004, Dec-31, Volume: 279, Issue:53 Topics: Apoptosis; Benzothiazoles; Blotting, Western; Carcinoma; Cell Cycle; Cell Cycle Proteins; Cell Line, Tumor; Cell Proliferation; Cyclin B; Cyclin B1; Cyclin-Dependent Kinase Inhibitor p21; DNA; Fluorescent Antibody Technique, Indirect; G2 Phase; Humans; Inhibitor of Apoptosis Proteins; Lung Neoplasms; Male; Microscopy, Phase-Contrast; Microtubule-Associated Proteins; Middle Aged; Mitosis; Models, Biological; Neoplasm Proteins; Oligonucleotides, Antisense; Phosphorylation; Protein Transport; Quercetin; RNA, Small Interfering; Survivin; Thiazoles; Threonine; Time Factors; Toluene; Transfection; Tumor Suppressor Protein p53	2004
Dynamin-2 regulates oxidized low-density lipoprotein-induced apoptosis of vascular smooth muscle cell. Circulation, 2004, Nov-23, Volume: 110, Issue:21 Topics: Animals; Apolipoproteins E; Apoptosis; Benzothiazoles; Coronary Vessels; Dynamin II; Endocytosis; Humans; Hyperlipoproteinemia Type II; Lipoproteins, LDL; Mice; Mice, Inbred C57BL; Mice, Knockout; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Receptors, LDL; Receptors, Oxidized LDL; Scavenger Receptors, Class E; Signal Transduction; Thiazoles; Toluene; Transfection; Tumor Suppressor Protein p53	2004
5-Aza-cytidine is a potent inhibitor of DNA methyltransferase 3a and induces apoptosis in HCT-116 colon cancer cells via Gadd45- and p53-dependent mechanisms. The Journal of pharmacology and experimental therapeutics, 2005, Volume: 312, Issue:2 Topics: Annexin A5; Apoptosis; Azacitidine; Benzothiazoles; Blotting, Western; Cell Cycle Proteins; Cell Line, Tumor; Cell Proliferation; Cyclin-Dependent Kinase Inhibitor p21; DNA (Cytosine-5-)-Methyltransferases; DNA Methyltransferase 3A; DNA, Complementary; DNA, Neoplasm; Down-Regulation; Enzyme Inhibitors; Flow Cytometry; G2 Phase; GADD45 Proteins; Humans; In Situ Nick-End Labeling; Intracellular Signaling Peptides and Proteins; Methylation; Proteins; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Thiazoles; Toluene; Tumor Suppressor Protein p53	2005
Deregulation of cell proliferation by polycyclic aromatic hydrocarbons in human breast carcinoma MCF-7 cells reflects both genotoxic and nongenotoxic events. Toxicological sciences : an official journal of the Society of Toxicology, 2005, Volume: 83, Issue:2 Topics: Benz(a)Anthracenes; Benzo(a)pyrene; Benzothiazoles; Breast Neoplasms; Bromodeoxyuridine; Carcinogens; Carcinoma; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Cell Survival; DNA Replication; Dose-Response Relationship, Drug; Drug Interactions; Epigenesis, Genetic; Estradiol; Estrogen Antagonists; Female; Fulvestrant; Humans; Receptors, Estrogen; Thiazoles; Toluene; Tumor Suppressor Protein p53	2005
Selective increase of dATP pools upon activation of deoxycytidine kinase in lymphocytes: implications in apoptosis. Nucleosides, nucleotides & nucleic acids, 2004, Volume: 23, Issue:8-9 Topics: Adenosine Triphosphate; Antineoplastic Agents; Apoptosis; Benzothiazoles; Cells, Cultured; Cladribine; Cytochromes c; Deoxycytidine Kinase; DNA Repair; Dose-Response Relationship, Drug; Enzyme Activation; Humans; Lymphocytes; Models, Biological; Palatine Tonsil; Phosphotransferases (Alcohol Group Acceptor); Thiazoles; Toluene; Tumor Suppressor Protein p53	2004
Inhibition of P53-related apoptosis had no effect on PrP(Sc) accumulation and prion disease incubation time. Neurobiology of disease, 2005, Volume: 18, Issue:2 Topics: Animals; Apoptosis; Benzothiazoles; Brain; Caspase 3; Caspases; Cell Line; Cricetinae; Disease Models, Animal; Disease Progression; Mesocricetus; Mice; Neurons; PrPSc Proteins; Scrapie; Thiazoles; Toluene; Treatment Outcome; Tumor Suppressor Protein p53	2005
Role of p53 and apoptosis in cerebral vasospasm after experimental subarachnoid hemorrhage. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2005, Volume: 25, Issue:5 Topics: Animals; Apoptosis; Basilar Artery; Benzothiazoles; Blotting, Western; Brain; Cerebral Angiography; Disease Models, Animal; Dogs; Endothelial Cells; Female; Immunohistochemistry; In Situ Nick-End Labeling; Male; Myocytes, Smooth Muscle; Subarachnoid Hemorrhage; Thiazoles; Toluene; Tumor Suppressor Protein p53; Vasospasm, Intracranial	2005
Novel cyclized Pifithrin-alpha p53 inactivators: synthesis and biological studies. Bioorganic & medicinal chemistry letters, 2005, Mar-15, Volume: 15, Issue:6 Topics: Animals; Benzothiazoles; Cerebral Cortex; Drug Stability; Etoposide; Mice; Models, Chemical; Molecular Structure; Neurons; Structure-Activity Relationship; Thiazoles; Toluene; Tumor Suppressor Protein p53	2005
Quinolinium salt as a potent inhibitor of lymphocyte apoptosis. Bioorganic & medicinal chemistry letters, 2005, Apr-01, Volume: 15, Issue:7 Topics: Antineoplastic Agents; Apoptosis; Benzothiazoles; Glucocorticoids; Humans; Lymphocytes; Quinolinium Compounds; Salts; Structure-Activity Relationship; Thiazoles; Toluene; Tumor Cells, Cultured	2005
Sensitization of cervical cancer cell lines to low-dose radiation by retinoic acid does not require functional p53. Gynecologic oncology, 2005, Volume: 97, Issue:1 Topics: Alitretinoin; Benzothiazoles; Cell Differentiation; Cell Line, Tumor; Cell Proliferation; Combined Modality Therapy; DNA Damage; Dose-Response Relationship, Radiation; Female; Genes, fos; Humans; Radiation-Sensitizing Agents; Thiazoles; Toluene; Transfection; Tretinoin; Tumor Suppressor Protein p53; Uterine Cervical Neoplasms	2005
Pharmaceutical-mediated inactivation of p53 sensitizes U87MG glioma cells to BCNU and temozolomide. International journal of cancer, 2005, Aug-20, Volume: 116, Issue:2 Topics: Antineoplastic Agents, Alkylating; Benzothiazoles; Brain Neoplasms; Carmustine; Dacarbazine; DNA Damage; Drug Interactions; Glioma; Humans; Temozolomide; Thiazoles; Toluene; Tumor Cells, Cultured; Tumor Suppressor Protein p53	2005
The p53 inhibitor pifithrin-alpha is a potent agonist of the aryl hydrocarbon receptor. The Journal of pharmacology and experimental therapeutics, 2005, Volume: 314, Issue:2 Topics: Apoptosis; Benzothiazoles; Blotting, Western; Cells, Cultured; Cytochrome P-450 CYP1A1; DNA; Electrophoretic Mobility Shift Assay; Humans; Ligands; Oligonucleotides; Plasmids; Polychlorinated Dibenzodioxins; Promoter Regions, Genetic; Receptors, Aryl Hydrocarbon; Reverse Transcriptase Polymerase Chain Reaction; Thiazoles; Toluene; Transfection; Tumor Suppressor Protein p53	2005
p53-dependent caspase-2 activation in mitochondrial release of apoptosis-inducing factor and its role in renal tubular epithelial cell injury. The Journal of biological chemistry, 2005, Sep-02, Volume: 280, Issue:35 Topics: Amino Acid Chloromethyl Ketones; Animals; Antineoplastic Agents; Apoptosis Inducing Factor; Benzothiazoles; Carrier Proteins; Caspase 2; Caspase 3; Caspase Inhibitors; Caspases; Cell Nucleus; Cisplatin; Cysteine Proteinase Inhibitors; Death Domain Receptor Signaling Adaptor Proteins; Enzyme Activation; Epithelial Cells; Flavoproteins; Kidney Tubules; Membrane Proteins; Mice; Mice, Knockout; Mitochondria; RNA, Small Interfering; Thiazoles; Toluene; Tumor Suppressor Protein p53	2005
Loss of tumor suppressor p53 decreases PTEN expression and enhances signaling pathways leading to activation of activator protein 1 and nuclear factor kappaB induced by UV radiation. Cancer research, 2005, Aug-01, Volume: 65, Issue:15 Topics: Animals; Benzothiazoles; Cell Line; Down-Regulation; Epidermis; JNK Mitogen-Activated Protein Kinases; MAP Kinase Signaling System; Mice; NF-kappa B; p38 Mitogen-Activated Protein Kinases; Phosphoric Monoester Hydrolases; Phosphorylation; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; PTEN Phosphohydrolase; Ribosomal Protein S6 Kinases, 70-kDa; RNA, Small Interfering; Thiazoles; Toluene; Transcription Factor AP-1; Transfection; Tumor Suppressor Protein p53; Tumor Suppressor Proteins; Ultraviolet Rays	2005
Pifithrin-alpha induced p53 inhibition does not affect liver regeneration after partial hepatectomy in mice. Journal of hepatology, 2005, Volume: 43, Issue:5 Topics: Animals; Apoptosis; Benzothiazoles; Cyclin-Dependent Kinase Inhibitor p21; Hepatectomy; Hepatocytes; In Situ Nick-End Labeling; Liver Regeneration; Male; Mice; Mice, Inbred C57BL; Organ Size; Proliferating Cell Nuclear Antigen; Thiazoles; Toluene; Tumor Suppressor Protein p53	2005
An evaluation of the ability of pifithrin-alpha and -beta to inhibit p53 function in two wild-type p53 human tumor cell lines. Molecular cancer therapeutics, 2005, Volume: 4, Issue:9 Topics: Animals; Benzothiazoles; Cell Cycle; Cell Line, Tumor; Cells, Cultured; Colonic Neoplasms; Female; Fibroblasts; Humans; Mice; Mitogen-Activated Protein Kinases; NIH 3T3 Cells; Ovarian Neoplasms; Phosphorylation; Radiation Tolerance; Radiation, Ionizing; Thiazoles; Toluene; Tumor Suppressor Protein p53	2005
Inhibitors of apoptosis in lymphocytes: synthesis and biological evaluation of compounds related to pifithrin-alpha. Journal of medicinal chemistry, 2005, Oct-06, Volume: 48, Issue:20 Topics: Animals; Apoptosis; Benzimidazoles; Benzothiazoles; Dexamethasone; Gamma Rays; Imidazoles; In Vitro Techniques; Lymphocytes; Mice; Mice, Inbred C57BL; Pyrrolidines; Structure-Activity Relationship; Thiazoles; Thymus Gland; Toluene; Tumor Suppressor Protein p53	2005
Effects of p53 inhibitor on survival and death of cells subjected to oxidative stress. Journal of physiology and pharmacology : an official journal of the Polish Physiological Society, 2005, Volume: 56 Suppl 4 Topics: Amyloid beta-Peptides; Animals; Apoptosis; Benzothiazoles; Brain Ischemia; Cell Death; Cell Shape; Cell Survival; Disease Models, Animal; Dose-Response Relationship, Drug; Gerbillinae; Male; Neurons; Neuroprotective Agents; Oxidative Stress; PC12 Cells; Peptide Fragments; Rats; Rats, Wistar; Reperfusion Injury; Toluene; Tumor Suppressor Protein p53	2005
DNA damage and nonhomologous end joining in excitotoxicity: neuroprotective role of DNA-PKcs in kainic acid-induced seizures. Hippocampus, 2005, Volume: 15, Issue:8 Topics: Animals; Benzothiazoles; Cell Death; Cells, Cultured; DNA Damage; DNA Repair; DNA-Activated Protein Kinase; DNA-Binding Proteins; Entorhinal Cortex; Excitatory Amino Acid Agonists; Heterozygote; Hippocampus; Immunohistochemistry; In Situ Nick-End Labeling; Kainic Acid; Membrane Potentials; Mice; Mice, Inbred C57BL; Mice, Neurologic Mutants; Mitochondria; Nerve Degeneration; Neurons; Nuclear Proteins; Seizures; Thiazoles; Toluene; Tumor Suppressor Protein p53	2005
Potent inhibition of carcinogen-bioactivating cytochrome P450 1B1 by the p53 inhibitor pifithrin alpha. Carcinogenesis, 2006, Volume: 27, Issue:3 Topics: Apoptosis; Aryl Hydrocarbon Hydroxylases; Benzo(a)pyrene; Benzothiazoles; Breast Neoplasms; Carcinogens; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP1B1; Humans; Leukemia; Macrophages; Microsomes, Liver; Protein Isoforms; Thiazoles; Toluene; Tumor Cells, Cultured; Tumor Suppressor Protein p53	2006
Regulation of p53 and suppression of apoptosis by the soluble guanylyl cyclase/cGMP pathway in human ovarian cancer cells. Oncogene, 2006, Apr-06, Volume: 25, Issue:15 Topics: Adenoviridae; Apoptosis; Atrial Natriuretic Factor; bcl-2-Associated X Protein; Benzothiazoles; Caspase 3; Caspases; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Cyclin-Dependent Kinase Inhibitor p21; Enzyme Activation; Enzyme Inhibitors; Female; Gene Expression Regulation, Neoplastic; Guanylate Cyclase; Half-Life; Humans; Mutation; Ovarian Neoplasms; Oxadiazoles; Phosphorylation; Proto-Oncogene Proteins c-mdm2; Quinoxalines; RNA, Small Interfering; Serine; Signal Transduction; Thiazoles; Toluene; Tumor Cells, Cultured; Tumor Suppressor Protein p53; X-Linked Inhibitor of Apoptosis Protein	2006
P53 mediates amosite asbestos-induced alveolar epithelial cell mitochondria-regulated apoptosis. American journal of respiratory cell and molecular biology, 2006, Volume: 34, Issue:4 Topics: Animals; Apoptosis; Asbestos, Amosite; Asbestosis; bcl-2-Associated X Protein; Benzothiazoles; Caspase 9; Caspases; Cell Line; Enzyme Activation; Epithelial Cells; Free Radical Scavengers; Humans; Iron Chelating Agents; Lung; Membrane Potentials; Mitochondrial Membranes; Oncogene Proteins, Viral; Phytic Acid; Promoter Regions, Genetic; Protein Transport; Pulmonary Alveoli; Rats; Reactive Oxygen Species; Repressor Proteins; Thiazoles; Toluene; Tumor Suppressor Protein p53	2006
Insulin-like growth factor-1 prevents Abeta[25-35]/(H2O2)- induced apoptosis in lymphocytes by reciprocal NF-kappaB activation and p53 inhibition via PI3K-dependent pathway. Growth factors (Chur, Switzerland), 2006, Volume: 24, Issue:1 Topics: Adult; Amyloid beta-Peptides; Apoptosis; Benzothiazoles; Chromones; Humans; Hydrogen Peroxide; In Vitro Techniques; Insulin-Like Growth Factor I; Lymphocytes; Male; Mitochondrial Membranes; Morpholines; NF-kappa B; Peptide Fragments; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Proline; Thiazoles; Thiocarbamates; Toluene; Tumor Suppressor Protein p53; Up-Regulation	2006
Histone deacetylase inhibitor-mediated radiosensitization of human cancer cells: class differences and the potential influence of p53. Clinical cancer research : an official journal of the American Association for Cancer Research, 2006, Feb-01, Volume: 12, Issue:3 Pt 1 Topics: Amides; Benzothiazoles; Biphenyl Compounds; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Dose-Response Relationship, Radiation; Enzyme Inhibitors; Fatty Acids, Unsaturated; Gene Expression Regulation; HeLa Cells; Histone Deacetylase Inhibitors; Histone Deacetylases; Humans; Hydroxamic Acids; Naphthalenes; Pyrones; Radiation-Sensitizing Agents; Thiazoles; Toluene; Tumor Cells, Cultured; Tumor Suppressor Protein p53	2006
Modulation of p53 transcriptional activity by PRIMA-1 and Pifithrin-alpha on staurosporine-induced apoptosis of wild-type and mutated p53 epithelial cells. Apoptosis : an international journal on programmed cell death, 2006, Volume: 11, Issue:5 Topics: Apoptosis; bcl-2-Associated X Protein; Benzothiazoles; Cell Culture Techniques; Cell Line, Transformed; Cell Line, Tumor; Cell Transformation, Viral; DNA, Neoplasm; Drug Combinations; Enzyme Inhibitors; Epithelial Cells; Female; HeLa Cells; Humans; Membrane Potentials; Membrane Proteins; Mitochondria; Mutation; Nerve Tissue Proteins; Papillomaviridae; Staurosporine; Thiazoles; Toluene; Transcription, Genetic; Tumor Suppressor Protein p53	2006
[Expression of p53 in neonatal mice following hypoxia-ischemia and effects of its inhibitor on neonatal brain injury]. Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics, 2006, Volume: 8, Issue:2 Topics: Animals; Animals, Newborn; Benzothiazoles; Brain; Dose-Response Relationship, Drug; Female; Hypoxia-Ischemia, Brain; Immunohistochemistry; Male; Mice; Mice, Inbred C57BL; Thiazoles; Toluene; Tumor Suppressor Protein p53	2006
[Effects of p53 inhibitor-alpha on the proliferation and apoptosis in large intestinal epithelial cells damaged by hyperthermic chemotherapy]. Zhonghua yi xue za zhi, 2006, Jan-10, Volume: 86, Issue:2 Topics: Apoptosis; Benzothiazoles; Blotting, Western; CDC2 Protein Kinase; Cell Proliferation; Cells, Cultured; Colon; Cyclin B; Cyclin B1; Epithelial Cells; Flow Cytometry; Humans; Hyperthermia, Induced; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Toluene; Tumor Suppressor Protein p53	2006
Evidence for p53-like-mediated stress responses in green algae. FEBS letters, 2006, May-29, Volume: 580, Issue:13 Topics: Amino Acid Sequence; Animals; Benzothiazoles; Chlamydomonas reinhardtii; Genes, p53; Molecular Sequence Data; Thiazoles; Toluene; Tumor Suppressor Protein p53; Volvox	2006
Multiple actions of pifithrin-alpha on doxorubicin-induced apoptosis in rat myoblastic H9c2 cells. American journal of physiology. Heart and circulatory physiology, 2006, Volume: 290, Issue:6 Topics: Animals; Antibiotics, Antineoplastic; Apoptosis; Benzothiazoles; Blotting, Western; Caspases; Cell Line, Tumor; Cytochromes c; Doxorubicin; Electrophoretic Mobility Shift Assay; Energy Metabolism; Enzyme Activation; Enzyme-Linked Immunosorbent Assay; fas Receptor; Genes, p53; Mitogen-Activated Protein Kinases; Myocardium; Neoplasms, Muscle Tissue; Oxidative Stress; Phosphorylation; Poly(ADP-ribose) Polymerases; Rats; Thiazoles; Toluene	2006
Vasospasm and p53-induced apoptosis in an experimental model of subarachnoid hemorrhage. Stroke, 2006, Volume: 37, Issue:7 Topics: Animals; Apoptosis Regulatory Proteins; Basilar Artery; Benzothiazoles; Blood-Brain Barrier; Blotting, Western; Body Water; Brain; Brain Chemistry; Cerebrovascular Circulation; Male; Models, Animal; Nerve Tissue Proteins; Permeability; Random Allocation; Rats; Rats, Sprague-Dawley; Single-Blind Method; Subarachnoid Hemorrhage; Thiazoles; Toluene; Tumor Suppressor Protein p53; Vasospasm, Intracranial	2006
Imino-tetrahydro-benzothiazole derivatives as p53 inhibitors: discovery of a highly potent in vivo inhibitor and its action mechanism. Journal of medicinal chemistry, 2006, Jun-15, Volume: 49, Issue:12 Topics: Administration, Topical; Animals; Antineoplastic Agents; Apoptosis; Axotomy; Benzothiazoles; Cells, Cultured; Cyclin-Dependent Kinase Inhibitor p21; Drug Design; Drug Stability; Etoposide; Imines; Male; Mice; Neocortex; Neuroprotective Agents; Optic Nerve; Phosphorylation; Prodrugs; Rats; Rats, Wistar; Retinal Ganglion Cells; Thiazoles; Toluene; Tumor Suppressor Protein p53; Vitreous Body	2006
Silibinin activates p53-caspase 2 pathway and causes caspase-mediated cleavage of Cip1/p21 in apoptosis induction in bladder transitional-cell papilloma RT4 cells: evidence for a regulatory loop between p53 and caspase 2. Carcinogenesis, 2006, Volume: 27, Issue:11 Topics: Apoptosis; Benzothiazoles; Caspase 2; Cell Line, Tumor; Cyclin-Dependent Kinase Inhibitor p21; Cytochromes c; Enzyme Inhibitors; Gene Expression Regulation, Neoplastic; Humans; Mitochondria; Models, Biological; Silybin; Silymarin; Toluene; Tumor Suppressor Protein p53; Urinary Bladder Neoplasms	2006
TEL/ETV6 induces apoptosis in 32D cells through p53-dependent pathways. Biochemical and biophysical research communications, 2006, Aug-25, Volume: 347, Issue:2 Topics: Animals; Apoptosis; Benzothiazoles; Blotting, Northern; Blotting, Western; Cell Line; Cell Proliferation; ETS Translocation Variant 6 Protein; Granulocyte Colony-Stimulating Factor; Humans; Interleukin-3; Membrane Potentials; Mitochondrial Membranes; Mutation; Proto-Oncogene Proteins c-bcl-2; Proto-Oncogene Proteins c-ets; Repressor Proteins; RNA, Messenger; Signal Transduction; Thiazoles; Toluene; Transcription, Genetic; Transfection; Tumor Suppressor Protein p53	2006
Ionizing radiation suppresses FAP-1 mRNA level in A549 cells via p53 activation. FEBS letters, 2006, Aug-07, Volume: 580, Issue:18 Topics: Benzothiazoles; Cell Line, Tumor; Down-Regulation; fas Receptor; Humans; Protein Phosphatase 1; Protein Tyrosine Phosphatase, Non-Receptor Type 13; Protein Tyrosine Phosphatases; Radiation, Ionizing; RNA, Messenger; Thiazoles; Toluene; Transcription, Genetic; Tumor Suppressor Protein p53	2006
Small-molecule inhibitor of p53 binding to mitochondria protects mice from gamma radiation. Nature chemical biology, 2006, Volume: 2, Issue:9 Topics: Animals; Apoptosis; Apoptosis Regulatory Proteins; Benzothiazoles; Cell Line; Dexamethasone; Gamma Rays; Humans; Male; Mice; Mice, Inbred C57BL; Mitochondria; Protein Binding; Protein Transport; Radiation Injuries, Experimental; Radiation-Protective Agents; Thiazoles; Thymus Gland; Toluene; Transcriptional Activation; Tumor Suppressor Protein p53; Ultraviolet Rays	2006
Primordial germ cell deficiency in the connexin 43 knockout mouse arises from apoptosis associated with abnormal p53 activation. Development (Cambridge, England), 2006, Volume: 133, Issue:17 Topics: Allantois; Animals; Apoptosis; Benzothiazoles; Cell Adhesion; Cell Movement; Connexin 43; Female; Genes, p53; Genes, Reporter; Genotype; Germ Cells; Mice; Mice, Knockout; Toluene; Transgenes	2006
Pifithrin-alpha, an inhibitor of p53 transactivation, alters the inflammatory process and delays tendon healing following acute injury. American journal of physiology. Regulatory, integrative and comparative physiology, 2007, Volume: 292, Issue:1 Topics: Achilles Tendon; Animals; Apoptosis; Benzothiazoles; Biomechanical Phenomena; Caspase 3; Collagen; Collagenases; Female; Gelatin; Genes, p53; Homeostasis; Hydroxyproline; Inflammation; Leukocytes; Rats; Rats, Wistar; Tendon Injuries; Toluene; Transcriptional Activation; Wound Healing	2007
p53 mediates particulate matter-induced alveolar epithelial cell mitochondria-regulated apoptosis. American journal of respiratory and critical care medicine, 2006, Dec-01, Volume: 174, Issue:11 Topics: Animals; Apoptosis; Benzothiazoles; Cells, Cultured; DNA Fragmentation; Genes, p53; Humans; Immunohistochemistry; In Situ Nick-End Labeling; Mitochondria; Particulate Matter; Pulmonary Alveoli; Rats; Reactive Oxygen Species; Toluene; Transcription, Genetic; Translocation, Genetic	2006
p21 and mTERT are novel markers for determining different ischemic time periods in renal ischemia-reperfusion injury. American journal of physiology. Renal physiology, 2007, Volume: 292, Issue:2 Topics: Animals; Benzothiazoles; Biomarkers; Cyclin-Dependent Kinase Inhibitor p16; Cyclin-Dependent Kinase Inhibitor p21; Ischemia; Kidney Diseases; Male; Mice; Mice, Inbred C57BL; Reperfusion Injury; Telomerase; Time; Toluene	2007
Pifithrin-alpha enhances chemosensitivity by a p38 mitogen-activated protein kinase-dependent modulation of the eukaryotic initiation factor 4E in malignant cholangiocytes. The Journal of pharmacology and experimental therapeutics, 2006, Volume: 319, Issue:3 Topics: Antimetabolites, Antineoplastic; Antineoplastic Agents; Benzothiazoles; Bile Duct Neoplasms; Cell Count; Cell Cycle; Cell Division; Cell Line, Tumor; Cholangiocarcinoma; Deoxycytidine; DNA, Neoplasm; Drug Synergism; Eukaryotic Initiation Factor-4E; Gemcitabine; Humans; Immunoblotting; Oligonucleotide Array Sequence Analysis; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Receptors, Aryl Hydrocarbon; Reverse Transcriptase Polymerase Chain Reaction; RNA Interference; Toluene	2006
Inhibition of p53 response in tumor stroma improves efficacy of anticancer treatment by increasing antiangiogenic effects of chemotherapy and radiotherapy in mice. Cancer research, 2006, Oct-01, Volume: 66, Issue:19 Topics: Angiogenesis Inhibitors; Animals; Antineoplastic Agents, Alkylating; Benzothiazoles; Carcinoma, Lewis Lung; Cell Line, Transformed; Cyclophosphamide; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Endothelial Cells; Fibroblasts; Imidazoles; Mice; Mice, Inbred C57BL; NIH 3T3 Cells; Protein Conformation; Radiation-Sensitizing Agents; Rats; Stromal Cells; Thiazoles; Toluene; Transduction, Genetic; Tumor Suppressor Protein p53	2006
Effects of intracellular calcium chelation and pifithrin-alpha on deoxynucleotide metabolism in human lymphocytes. Nucleosides, nucleotides & nucleic acids, 2006, Volume: 25, Issue:9-11 Topics: Benzothiazoles; Calcium; Cells, Cultured; Chelating Agents; Deoxycytidine Kinase; Egtazic Acid; Enzyme Activation; Gene Expression Regulation; Humans; Lymphocytes; Nucleotides; Toluene	2006
Pifithrin-alpha attenuates p53-mediated apoptosis and improves cardiac function in response to myocardial ischemia/reperfusion in aged rats. Shock (Augusta, Ga.), 2006, Volume: 26, Issue:6 Topics: Animals; Apoptosis; bcl-2-Associated X Protein; Benzothiazoles; DNA Fragmentation; Electrocardiography; Evans Blue; Heart; Myocardial Ischemia; Myocytes, Cardiac; Proto-Oncogene Proteins c-bcl-2; Rats; Rats, Inbred F344; Reperfusion Injury; Toluene; Tumor Suppressor Protein p53	2006
Inhibition of apoptotic protein p53 lowers the threshold of isoflurane-induced cardioprotection during early reperfusion in rabbits. Anesthesia and analgesia, 2006, Volume: 103, Issue:6 Topics: Animals; Benzothiazoles; Glycogen Synthase Kinases; Ischemic Preconditioning, Myocardial; Isoflurane; Male; Mitochondrial Membrane Transport Proteins; Mitochondrial Permeability Transition Pore; Myocardial Infarction; Myocardial Reperfusion Injury; Phosphatidylinositol 3-Kinases; Phosphorylation; Rabbits; Toluene; Tumor Suppressor Protein p53	2006
Role of p53 in irinotecan-induced intestinal cell death and mucosal damage. Anti-cancer drugs, 2007, Volume: 18, Issue:2 Topics: Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Benzothiazoles; Blotting, Western; Camptothecin; Cell Adhesion; Cell Count; Cell Death; Cell Line; Cell Line, Tumor; Cell Survival; Colon; Cyclin-Dependent Kinase Inhibitor p21; Epithelial Cells; Female; Gene Expression Regulation, Neoplastic; Genes, bcl-2; Immunohistochemistry; Intestinal Mucosa; Irinotecan; Proliferating Cell Nuclear Antigen; Rats; Toluene; Tumor Suppressor Protein p53	2007
Human herpesvirus 6B inhibits cell proliferation by a p53-independent pathway. Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology, 2006, Volume: 37 Suppl 1 Topics: Benzothiazoles; Cell Cycle; Cell Line; Cell Proliferation; Cyclin-Dependent Kinase Inhibitor p21; DNA-Binding Proteins; Herpesvirus 6, Human; Humans; Toluene; Tumor Suppressor Protein p53; Viral Proteins; Virus Replication	2006
Endogenously generated hydrogen peroxide induces apoptosis via mitochondrial damage independent of NF-kappaB and p53 activation in bovine embryos. Theriogenology, 2007, Apr-15, Volume: 67, Issue:7 Topics: Animals; Apoptosis; Benzothiazoles; Caspase 3; Caspase Inhibitors; Cattle; Embryonic Development; Female; Hydrogen Peroxide; Membrane Potential, Mitochondrial; Microscopy, Fluorescence; NF-kappa B; Oligopeptides; Oocytes; Proline; Thiocarbamates; Toluene; Tumor Suppressor Protein p53	2007
NF-kappaB contributes to 6-hydroxydopamine-induced apoptosis of nigral dopaminergic neurons through p53. Brain research, 2007, May-11, Volume: 1145 Topics: Active Transport, Cell Nucleus; Animals; Apoptosis; Benzothiazoles; DNA Fragmentation; Dopamine; Male; Nerve Degeneration; Neurons; Neurotoxins; NF-kappa B; Oxidative Stress; Oxidopamine; Parkinsonian Disorders; Peptides; Rats; Rats, Sprague-Dawley; Signal Transduction; Substantia Nigra; Sympatholytics; Toluene; Tumor Suppressor Protein p53; Tyrosine 3-Monooxygenase	2007
Zebrafish tp53 knockdown extends the survival of irradiated zebrafish embryos more effectively than the p53 inhibitor pifithrin-alpha. Cancer biology & therapy, 2007, Volume: 6, Issue:5 Topics: Animals; Benzothiazoles; Dose-Response Relationship, Radiation; Embryo, Nonmammalian; Models, Animal; Oligodeoxyribonucleotides; Phenotype; Radiation-Sensitizing Agents; Survival Rate; Toluene; Tumor Suppressor Protein p53; Zebrafish	2007
Transcription factor p53 in degenerating spinal cords. Brain research, 2007, May-30, Volume: 1150 Topics: Age Factors; Amyotrophic Lateral Sclerosis; Animals; Behavior, Animal; Benzothiazoles; Case-Control Studies; Caspase 3; Cell Survival; Disease Models, Animal; Enzyme Inhibitors; Gene Expression Regulation; Humans; Mice; Mice, Mutant Strains; Microarray Analysis; Motor Neurons; Nerve Degeneration; Organ Culture Techniques; RNA, Messenger; Spinal Cord; Toluene; Tumor Suppressor Protein p53	2007
Redox control of G(1)/S cell cycle regulators during nitric oxide-mediated cell cycle arrest. Journal of cellular physiology, 2007, Volume: 212, Issue:3 Topics: Animals; Benzothiazoles; Buthionine Sulfoximine; Cell Cycle Proteins; Cell Proliferation; Cyclin D; Cyclin-Dependent Kinase Inhibitor p21; Cyclins; DNA Damage; Dose-Response Relationship, Drug; Enzyme Inhibitors; Fibroblasts; G1 Phase; Glutamate-Cysteine Ligase; Glutathione; Mice; NIH 3T3 Cells; Nitric Oxide; Nitric Oxide Donors; Oxidation-Reduction; Phosphorylation; Retinoblastoma Protein; S Phase; Toluene; Transfection; Triazenes; Tumor Suppressor Protein p53	2007
Delayed neuronal death after brain trauma involves p53-dependent inhibition of NF-kappaB transcriptional activity. Cell death and differentiation, 2007, Volume: 14, Issue:8 Topics: Animals; Apoptosis; Benzothiazoles; Brain Injuries; Disease Models, Animal; Female; Humans; Male; Mice; Mice, Inbred C57BL; Nerve Degeneration; NF-kappa B; Pregnancy; Rats; Rats, Sprague-Dawley; Toluene; Transcription, Genetic; Tumor Suppressor Protein p53; X-Linked Inhibitor of Apoptosis Protein	2007
Differential protection and transactivation of P53, P21, Bcl2, PCNA, cyclin G, and MDM2 genes in rat liver and the HepG2 cell line upon exposure to pifithrin. Biomedical sciences instrumentation, 2007, Volume: 43 Topics: Animals; Arsenic; Benzothiazoles; Cadmium; Cell Line, Tumor; Cells, Cultured; Cytoprotection; DNA Damage; DNA Repair; Dose-Response Relationship, Drug; Drug Combinations; Gene Expression Regulation; Hepatoblastoma; Hepatocytes; Humans; Lethal Dose 50; Liver Neoplasms; Male; Neoplasm Proteins; Rats; Rats, Wistar; Toluene; Tumor Suppressor Protein p53	2007
Activation and involvement of p53 in cisplatin-induced nephrotoxicity. American journal of physiology. Renal physiology, 2007, Volume: 293, Issue:4 Topics: Acute Kidney Injury; Animals; Antineoplastic Agents; Apoptosis; Benzothiazoles; Cisplatin; Disease Models, Animal; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Nephrons; Phosphorylation; Toluene; Tumor Suppressor Protein p53	2007
MAPK inhibitors and pifithrin-alpha block cinnamaldehyde-induced apoptosis in human PLC/PRF/5 cells. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 2007, Volume: 45, Issue:12 Topics: Anthracenes; Antineoplastic Agents, Phytogenic; Apoptosis; Benzothiazoles; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line, Tumor; Cinnamomum aromaticum; Enzyme Inhibitors; Flavonoids; Humans; JNK Mitogen-Activated Protein Kinases; Phytotherapy; Plant Extracts; Toluene	2007
Involvement of both tumor necrosis factor-alpha-induced necrosis and p53-mediated caspase-dependent apoptosis in nephrotoxicity of cisplatin. Apoptosis : an international journal on programmed cell death, 2007, Volume: 12, Issue:10 Topics: Acetylcysteine; Animals; Antineoplastic Agents; Apoptosis; Benzothiazoles; Caspase Inhibitors; Caspases; Cell Line; Cisplatin; Cysteine Proteinase Inhibitors; Enzyme Activation; Free Radical Scavengers; Kidney Tubules; Necrosis; Oligopeptides; p38 Mitogen-Activated Protein Kinases; Rats; Reactive Oxygen Species; Swine; Toluene; Tumor Necrosis Factor-alpha; Tumor Suppressor Protein p53	2007
Bid is not required for Bax translocation during UV-induced apoptosis. Cellular signalling, 2007, Volume: 19, Issue:12 Topics: Adenocarcinoma; Animals; Apoptosis; bcl-2-Associated X Protein; bcl-X Protein; Benzothiazoles; BH3 Interacting Domain Death Agonist Protein; Caspase 3; Caspase 8; Caspase Inhibitors; Cell Line, Tumor; Chlorocebus aethiops; COS Cells; Cysteine Proteinase Inhibitors; Enzyme Activation; Fluorescence Resonance Energy Transfer; Humans; Lung Neoplasms; Oligopeptides; Protein Transport; Recombinant Fusion Proteins; RNA Interference; RNA, Small Interfering; Time Factors; Toluene; Transfection; Tumor Suppressor Protein p53; Ultraviolet Rays	2007
Increased expression of the pro-apoptotic Bcl2 family member PUMA is required for mitochondrial release of cytochrome C and the apoptosis associated with skeletal myoblast differentiation. Apoptosis : an international journal on programmed cell death, 2007, Volume: 12, Issue:12 Topics: Animals; Apoptosis; Apoptosis Regulatory Proteins; Benzothiazoles; Caspase 3; Caspase 9; Cell Differentiation; Culture Media; Cytochromes c; DNA Fragmentation; Enzyme Activation; Mice; Mitochondria; Myoblasts, Skeletal; Protein Biosynthesis; Proto-Oncogene Proteins c-bcl-2; Toluene; Tumor Suppressor Protein p53; Tumor Suppressor Proteins	2007
Temozolomide induces senescence but not apoptosis in human melanoma cells. British journal of cancer, 2007, Nov-05, Volume: 97, Issue:9 Topics: Antineoplastic Agents, Alkylating; Apoptosis; Benzothiazoles; Cell Division; Cellular Senescence; Dacarbazine; G2 Phase; Humans; Lymphoma; Melanoma; O(6)-Methylguanine-DNA Methyltransferase; Temozolomide; Toluene; Tumor Cells, Cultured; Tumor Suppressor Protein p53	2007
Histone deacetylase inhibitors induce in human hepatoma HepG2 cells acetylation of p53 and histones in correlation with apoptotic effects. International journal of oncology, 2008, Volume: 32, Issue:1 Topics: Acetylation; Antineoplastic Agents; Apoptosis; Benzothiazoles; Carcinoma, Hepatocellular; Cell Line, Tumor; DNA Damage; Enzyme Inhibitors; Histone Deacetylase Inhibitors; Histones; Humans; Hydroxamic Acids; Liver Neoplasms; Proto-Oncogene Proteins c-mdm2; RNA, Small Interfering; Toluene; Tumor Suppressor Protein p53; Vorinostat	2008
HSP27 regulates p53 transcriptional activity in doxorubicin-treated fibroblasts and cardiac H9c2 cells: p21 upregulation and G2/M phase cell cycle arrest. American journal of physiology. Heart and circulatory physiology, 2008, Volume: 294, Issue:4 Topics: Amino Acid Sequence; Animals; Antibiotics, Antineoplastic; Benzothiazoles; Blotting, Western; Cell Cycle; Cell Division; Cell Line; Cyclin-Dependent Kinase Inhibitor p21; DNA-Binding Proteins; Dose-Response Relationship, Drug; Doxorubicin; Fibroblasts; Flow Cytometry; G2 Phase; Heat Shock Transcription Factors; Heat-Shock Proteins; HSP27 Heat-Shock Proteins; Immunoprecipitation; Mice; Mice, Knockout; Molecular Sequence Data; Myocytes, Cardiac; Neoplasm Proteins; Protein Binding; Rats; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Toluene; Transcription Factors; Transcription, Genetic; Transcriptional Activation; Tumor Suppressor Protein p53; Up-Regulation	2008
Inhibition of p53 by pifithrin-alpha reduces myocyte apoptosis and leukocyte transmigration in aged rat hearts following 24 hours of reperfusion. Shock (Augusta, Ga.), 2008, Volume: 30, Issue:5 Topics: Animals; Apoptosis; Benzothiazoles; Cell Movement; Enzyme-Linked Immunosorbent Assay; Immunohistochemistry; Leukocytes; Male; Muscle Cells; Myocardial Reperfusion Injury; Rats; Toluene; Tumor Suppressor Protein p53	2008
Apigenin-induced prostate cancer cell death is initiated by reactive oxygen species and p53 activation. Free radical biology & medicine, 2008, May-15, Volume: 44, Issue:10 Topics: Acetylcysteine; Antineoplastic Agents, Phytogenic; Antioxidants; Apigenin; Apoptosis; Benzothiazoles; Cell Death; Cell Line, Tumor; Cyclin-Dependent Kinase Inhibitor p21; Humans; Male; Membrane Potential, Mitochondrial; Phosphorylation; Prostatic Neoplasms; Proto-Oncogene Proteins c-mdm2; Reactive Oxygen Species; Signal Transduction; Toluene; Transcription Factor RelA; Tumor Suppressor Protein p14ARF; Tumor Suppressor Protein p53	2008
Pifithrin-alpha reduces cerebral vasospasm by attenuating apoptosis of endothelial cells in a subarachnoid haemorrhage model of rat. Chinese medical journal, 2008, Mar-05, Volume: 121, Issue:5 Topics: Animals; Apoptosis; Benzothiazoles; Blotting, Western; Disease Models, Animal; Endothelial Cells; Male; Rats; Rats, Sprague-Dawley; Subarachnoid Hemorrhage; Toluene; Tumor Suppressor Protein p53; Vasospasm, Intracranial	2008
Inhibition of p73 function by Pifithrin-alpha as revealed by studies in zebrafish embryos. Cell cycle (Georgetown, Tex.), 2008, May-01, Volume: 7, Issue:9 Topics: Animals; Apoptosis; Benzothiazoles; Cell Survival; Chromosome Aberrations; DNA Damage; Down-Regulation; Embryo, Nonmammalian; Enzyme Inhibitors; Gene Expression Regulation, Developmental; Genes, Reporter; Oligodeoxyribonucleotides, Antisense; Radiation, Ionizing; Toluene; Transcription Factors; Transcriptional Activation; Tumor Suppressor Protein p53; Zebrafish; Zebrafish Proteins	2008
Restriction of human herpesvirus 6B replication by p53. The Journal of general virology, 2008, Volume: 89, Issue:Pt 5 Topics: Benzothiazoles; Cell Line; Cytopathogenic Effect, Viral; Enzyme Inhibitors; Epithelial Cells; Herpesvirus 6, Human; Humans; Toluene; Tumor Suppressor Protein p53; Virus Replication	2008
Contribution of p53-mediated Bax transactivation in theaflavin-induced mammary epithelial carcinoma cell apoptosis. Apoptosis : an international journal on programmed cell death, 2008, Volume: 13, Issue:6 Topics: Apoptosis; bcl-2-Associated X Protein; Benzothiazoles; Biflavonoids; Breast Neoplasms; Caspases; Catechin; Cyclosporine; Humans; Membrane Potential, Mitochondrial; Mitochondria; Toluene; Transcriptional Activation; Tumor Suppressor Protein p53; Up-Regulation	2008
Autophagy is cytoprotective during cisplatin injury of renal proximal tubular cells. Kidney international, 2008, Volume: 74, Issue:5 Topics: Adenine; Animals; Apoptosis; Apoptosis Regulatory Proteins; Autophagy; Beclin-1; Benzothiazoles; Cell Line; Cisplatin; Genes, bcl-2; Humans; Kidney Tubules, Proximal; Male; Mice; Mice, Inbred C57BL; Microscopy, Electron, Transmission; Proteins; Rats; RNA, Small Interfering; Toluene; Transfection; Tumor Suppressor Protein p53	2008
Cyclic pifithrin-alpha sensitizes wild type p53 tumor cells to antimicrotubule agent-induced apoptosis. Neoplasia (New York, N.Y.), 2008, Volume: 10, Issue:6 Topics: Apoptosis; Benzothiazoles; Cell Line, Tumor; Dose-Response Relationship, Drug; Female; Fibroblasts; Gene Expression Regulation, Neoplastic; Genes, p53; Humans; Microtubules; Ovarian Neoplasms; Phosphorylation; Spindle Apparatus; Toluene; Tubulin Modulators; Tumor Suppressor Protein p53	2008
Inhibition of p53 transcriptional activity: a potential target for future development of therapeutic strategies for primary demyelination. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2008, Jun-11, Volume: 28, Issue:24 Topics: Animals; Benzothiazoles; Cells, Cultured; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Enzyme Inhibitors; Lateral Ventricles; Mice; Mice, Inbred C57BL; Mice, Knockout; Microglia; Oligodendroglia; Oligonucleotide Array Sequence Analysis; Toluene; Transcription, Genetic; Tumor Suppressor Protein p53	2008
Basal and UV-induced MMP-1 expression are inhibited by p53 in human dermal fibroblasts. Experimental dermatology, 2008, Volume: 17, Issue:11 Topics: Adenoviridae; Benzothiazoles; Blotting, Western; Cells, Cultured; Dermis; Etoposide; Fibroblasts; Humans; Matrix Metalloproteinase 1; Phosphorylation; Proto-Oncogene Proteins c-fos; Proto-Oncogene Proteins c-jun; Toluene; Transduction, Genetic; Tumor Suppressor Protein p53; Ultraviolet Rays; Young Adult	2008
The alpha1D-adrenergic receptor induces vascular smooth muscle apoptosis via a p53-dependent mechanism. Molecular pharmacology, 2008, Volume: 74, Issue:4 Topics: Acetophenones; Adrenergic alpha-1 Receptor Antagonists; Anthracenes; Aorta; Apoptosis; Benzothiazoles; Cells, Cultured; Culture Media, Serum-Free; Dioxanes; Dose-Response Relationship, Drug; Enzyme Inhibitors; Flavonoids; Humans; Imidazoles; Mitochondria; Muscle, Smooth, Vascular; Phenylephrine; Piperazines; Prazosin; Pyridines; Reactive Oxygen Species; Receptors, Adrenergic, alpha-1; Time Factors; Toluene; Tumor Suppressor Protein p53	2008
Coupling of mutated Met variants to DNA repair via Abl and Rad51. Cancer research, 2008, Jul-15, Volume: 68, Issue:14 Topics: Active Transport, Cell Nucleus; Animals; Benzothiazoles; DNA Damage; DNA Repair; Genes, abl; Genetic Variation; Indoles; Mice; Mutation; NIH 3T3 Cells; Phosphorylation; Piperazines; Rad51 Recombinase; Radiation-Sensitizing Agents; Sulfonamides; Toluene; Tyrosine	2008
Regulation of MMP-9 by p53 in first trimester cytotrophoblastic cells. Human reproduction (Oxford, England), 2008, Volume: 23, Issue:10 Topics: Benzothiazoles; Blotting, Western; Etoposide; Female; Gene Expression Regulation, Developmental; Humans; Matrix Metalloproteinase 9; Mutation; Pregnancy; Pregnancy Trimester, First; Promoter Regions, Genetic; Toluene; Trophoblasts; Tumor Suppressor Protein p53	2008
Regulation of Bax activation and apoptotic response to UV irradiation by p53 transcription-dependent and -independent pathways. Cancer letters, 2008, Nov-28, Volume: 271, Issue:2 Topics: Apoptosis; bcl-2-Associated X Protein; Benzothiazoles; Cell Line, Tumor; Cycloheximide; DNA Primers; Humans; Microscopy, Confocal; Microscopy, Fluorescence; Protein Transport; Reverse Transcriptase Polymerase Chain Reaction; Toluene; Transcription, Genetic; Tumor Suppressor Protein p53; Ultraviolet Rays	2008
PCB126 exposure disrupts zebrafish ventricular and branchial but not early neural crest development. Toxicological sciences : an official journal of the Society of Toxicology, 2008, Volume: 106, Issue:1 Topics: Abnormalities, Multiple; Animals; Animals, Genetically Modified; Benzothiazoles; Body Patterning; Branchial Region; Cell Death; Cell Differentiation; Cell Movement; Cell Proliferation; Environmental Pollutants; Heart Defects, Congenital; Heart Ventricles; Jaw Abnormalities; Morpholines; Neural Crest; Oligonucleotides; Phenotype; Polychlorinated Biphenyls; Time Factors; Toluene; Troponin T; Tumor Suppressor Protein p53; Zebrafish	2008
p53-mediated apoptosis of CLL cells: evidence for a transcription-independent mechanism. Blood, 2008, Nov-01, Volume: 112, Issue:9 Topics: Adult; Aged; Aged, 80 and over; Apoptosis; Apoptosis Regulatory Proteins; Benzothiazoles; Chlorambucil; Female; Humans; In Vitro Techniques; Leukemia, Lymphocytic, Chronic, B-Cell; Male; Middle Aged; Mitochondria; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Toluene; Transcription, Genetic; Tumor Suppressor Protein p53; Vidarabine	2008
Inhibition of glycogen synthase kinase or the apoptotic protein p53 lowers the threshold of helium cardioprotection in vivo: the role of mitochondrial permeability transition. Anesthesia and analgesia, 2008, Volume: 107, Issue:3 Topics: Animals; Apoptosis; Atractyloside; Benzothiazoles; Cardiotonic Agents; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Glycogen Synthase Kinases; Helium; Indoles; Male; Maleimides; Mitochondria; Oxygen; Permeability; Rabbits; Toluene; Tumor Suppressor Protein p53	2008
ERKs/p53 signal transduction pathway is involved in doxorubicin-induced apoptosis in H9c2 cells and cardiomyocytes. American journal of physiology. Heart and circulatory physiology, 2008, Volume: 295, Issue:5 Topics: Active Transport, Cell Nucleus; Animals; Animals, Newborn; Antibiotics, Antineoplastic; Apoptosis; bcl-2-Associated X Protein; Benzothiazoles; Butadienes; Caspases; Cells, Cultured; Doxorubicin; Membrane Potential, Mitochondrial; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Myocytes, Cardiac; Nitriles; Phosphorylation; Poly(ADP-ribose) Polymerases; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-bcl-2; Rats; Rats, Sprague-Dawley; Signal Transduction; Time Factors; Toluene; Tumor Suppressor Protein p53	2008
p53 regulates renal expression of HIF-1{alpha} and pVHL under physiological conditions and after ischemia-reperfusion injury. American journal of physiology. Renal physiology, 2008, Volume: 295, Issue:6 Topics: Acute Kidney Injury; Animals; Benzothiazoles; Cell Line; Hypoxia-Inducible Factor 1, alpha Subunit; Kidney Cortex; Kidney Medulla; Kidney Tubules; Male; Microscopy, Confocal; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Toluene; Tumor Suppressor Protein p53; Up-Regulation; Von Hippel-Lindau Tumor Suppressor Protein	2008
Diesel exhaust particles induce apoptosis via p53 and Mdm2 in J774A.1 macrophage cell line. Toxicology in vitro : an international journal published in association with BIBRA, 2009, Volume: 23, Issue:1 Topics: Air Pollutants; Animals; Apoptosis; bcl-2-Associated X Protein; Benzothiazoles; Cell Line; Cell Survival; Dose-Response Relationship, Drug; Gene Expression Regulation; Macrophages; Mice; Mice, Inbred BALB C; Proto-Oncogene Proteins c-mdm2; RNA, Messenger; Toluene; Tumor Suppressor Protein p53; Vehicle Emissions	2009
Selective activation of p38 mitogen-activated protein kinase in dopaminergic neurons of substantia nigra leads to nuclear translocation of p53 in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated mice. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2008, Nov-19, Volume: 28, Issue:47 Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Analysis of Variance; Animals; Benzothiazoles; Brain; Cells, Cultured; Disease Models, Animal; Dopamine; Enzyme Activation; Enzyme Inhibitors; Fetus; Humans; Imidazoles; Male; MAP Kinase Kinase 4; Mice; Mice, Inbred C57BL; MPTP Poisoning; Neurons; p38 Mitogen-Activated Protein Kinases; Parkinson Disease; Protein Transport; Pyrimidines; Stem Cells; Substantia Nigra; Time Factors; Toluene; Tumor Suppressor Protein p53; Tyrosine 3-Monooxygenase; Up-Regulation	2008
A role for p53 in the beta-amyloid-mediated regulation of the lysosomal system. Neurobiology of aging, 2010, Volume: 31, Issue:10 Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Animals, Newborn; Apoptosis; bcl-2-Associated X Protein; Benzothiazoles; Cathepsin L; Cell Culture Techniques; Cerebral Cortex; Lysosomes; Male; Neurons; Phosphoproteins; Rats; Rats, Wistar; Toluene; Tumor Suppressor Protein p53	2010
p53 Small-molecule inhibitor enhances temozolomide cytotoxic activity against intracranial glioblastoma xenografts. Cancer research, 2008, Dec-15, Volume: 68, Issue:24 Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Benzothiazoles; Brain Neoplasms; Dacarbazine; Drug Synergism; Glioblastoma; Humans; Mice; Poly(ADP-ribose) Polymerases; Temozolomide; Toluene; Tumor Suppressor Protein p53; Xenograft Model Antitumor Assays	2008
Sex-specific differences in fetal germ cell apoptosis induced by ionizing radiation. Human reproduction (Oxford, England), 2009, Volume: 24, Issue:3 Topics: Animals; Apoptosis; Benzothiazoles; Dose-Response Relationship, Radiation; Female; Genes, p53; Germ Cells; Histones; Humans; Male; Mice; Mice, Transgenic; Organ Culture Techniques; Radiation, Ionizing; Sex Factors; Toluene	2009
Potential role of PUMA in delayed death of hippocampal CA1 neurons after transient global cerebral ischemia. Stroke, 2009, Volume: 40, Issue:2 Topics: Animals; Apoptosis Regulatory Proteins; bcl-2-Associated X Protein; bcl-X Protein; Benzothiazoles; Benzoxazines; Blotting, Western; Cell Death; Cytosol; Hippocampus; Immunohistochemistry; Immunoprecipitation; Ischemic Attack, Transient; Mitochondria; Neurons; Oxazines; Oxidative Stress; Rats; Rats, Transgenic; Superoxide Dismutase; Toluene; Up-Regulation	2009
Bmp2 is required for cephalic neural tube closure in the mouse. Developmental dynamics : an official publication of the American Association of Anatomists, 2009, Volume: 238, Issue:1 Topics: Animals; Apoptosis; Benzothiazoles; Body Patterning; Bone Morphogenetic Protein 2; Chimera; Female; In Situ Hybridization; Mice; Mice, Knockout; Neural Tube; Paired Box Transcription Factors; PAX3 Transcription Factor; Phenotype; Pregnancy; Signal Transduction; Toluene; Tumor Suppressor Protein p53	2009
The essential role of p53 in hyperpigmentation of the skin via regulation of paracrine melanogenic cytokine receptor signaling. The Journal of biological chemistry, 2009, Feb-13, Volume: 284, Issue:7 Topics: Aging; Animals; Benzothiazoles; Cytokines; Epidermal Cells; Epidermis; Female; Gene Expression Regulation; Humans; Inflammation; Keratinocytes; MAP Kinase Signaling System; Melanins; Melanocytes; Mice; Middle Aged; Paracrine Communication; Pro-Opiomelanocortin; Receptors, Cytokine; Skin Pigmentation; Toluene; Transcription, Genetic; Tumor Suppressor Protein p53; Ultraviolet Rays	2009
Pifithrin-alpha protects against DNA damage-induced apoptosis downstream of mitochondria independent of p53. Cell death and differentiation, 2009, Volume: 16, Issue:6 Topics: Apoptosis; Apoptosomes; Benzothiazoles; Caspase 3; Caspase 9; Cell Line; Cyclin D1; Cyclin-Dependent Kinases; DNA Damage; Humans; Mitochondria; Radiation, Ionizing; Retinoblastoma Protein; RNA, Small Interfering; Toluene; Tumor Suppressor Protein p53	2009
Possible involvement of NO in the stimulating effect of pifithrins on survival of hemopoietic clonogenic cells. Biochemistry. Biokhimiia, 2009, Volume: 74, Issue:2 Topics: Animals; Benzothiazoles; Cell Survival; Hematopoietic Stem Cells; Imidazoles; Male; Mice; Mice, Inbred C57BL; Mice, Inbred CBA; Nitric Oxide; Radiation-Protective Agents; Spleen; Structure-Activity Relationship; Toluene; Tumor Suppressor Protein p53	2009
p53 mediates mitochondria dysfunction-triggered autophagy activation and cell death in rat striatum. Autophagy, 2009, Volume: 5, Issue:3 Topics: Adenine; Animals; Apoptosis Regulatory Proteins; Autophagy; bcl-2-Associated X Protein; Benzothiazoles; Cell Death; Corpus Striatum; Enzyme Inhibitors; Humans; Macrolides; Membrane Proteins; Neurons; Neurotoxins; Nitro Compounds; Propionates; Proteins; Rats; Rats, Sprague-Dawley; Signal Transduction; Toluene; Tumor Suppressor Protein p53	2009
Pifithrin-alpha decreases the radioprotective efficacy of a Podophyllum hexandrum Himalayan mayapple fraction REC-2006 in HepG2 cells. Biotechnology and applied biochemistry, 2009, Jul-09, Volume: 54, Issue:1 Topics: Apoptosis; Apoptosis Regulatory Proteins; Benzothiazoles; Cell Cycle Proteins; Cell Line, Tumor; Cell Proliferation; DNA-Binding Proteins; DNA, Neoplasm; Drug Interactions; Heat Shock Transcription Factors; HSP70 Heat-Shock Proteins; Humans; Plant Extracts; Podophyllum; Proto-Oncogene Proteins c-bcl-2; Proto-Oncogene Proteins c-mdm2; Radiation-Protective Agents; ras GTPase-Activating Proteins; Toluene; Transcription Factors; Tumor Suppressor Protein p53	2009
The transcription-independent mitochondrial p53 program is a major contributor to nutlin-induced apoptosis in tumor cells. Cell cycle (Georgetown, Tex.), 2009, Jun-01, Volume: 8, Issue:11 Topics: Antineoplastic Agents; Apoptosis; Benzothiazoles; Cell Line, Tumor; Humans; Imidazoles; Mitochondria; Piperazines; Protein Binding; Proto-Oncogene Proteins c-mdm2; Toluene; Transcription, Genetic; Translocation, Genetic; Tumor Suppressor Protein p53; Ubiquitination	2009
Differential requirement for nucleostemin in embryonic stem cell and neural stem cell viability. Stem cells (Dayton, Ohio), 2009, Volume: 27, Issue:5 Topics: Animals; Apoptosis; Benzothiazoles; Biomarkers; Carrier Proteins; Caspase 3; Cell Proliferation; Cell Survival; Doxycycline; Embryonic Stem Cells; Enzyme Activation; Gene Expression Regulation, Developmental; GTP-Binding Proteins; Mice; Neurons; Nuclear Proteins; Phenotype; Pluripotent Stem Cells; RNA-Binding Proteins; Toluene; Tumor Suppressor Protein p53	2009
PUMA promotes Bax translocation by both directly interacting with Bax and by competitive binding to Bcl-X L during UV-induced apoptosis. Molecular biology of the cell, 2009, Volume: 20, Issue:13 Topics: Apoptosis; Apoptosis Regulatory Proteins; bcl-2-Associated X Protein; bcl-X Protein; Benzothiazoles; Binding, Competitive; Blotting, Western; Cell Line, Tumor; Cell Survival; Cycloheximide; Dose-Response Relationship, Radiation; Fluorescence Resonance Energy Transfer; Humans; Immunoprecipitation; Luminescent Proteins; Microscopy, Confocal; Protein Binding; Protein Transport; Proto-Oncogene Proteins; Recombinant Fusion Proteins; Time Factors; Toluene; Transfection; Ultraviolet Rays	2009
Delayed treatment with a p53 inhibitor enhances recovery in stroke brain. Annals of neurology, 2009, Volume: 65, Issue:5 Topics: Adult Stem Cells; Analysis of Variance; Animals; Benzothiazoles; Brain; Bromodeoxyuridine; Cell Differentiation; Cell Movement; Cells, Cultured; Cerebral Ventricles; Disease Models, Animal; Embryo, Mammalian; Glial Fibrillary Acidic Protein; In Situ Nick-End Labeling; Infarction, Middle Cerebral Artery; Male; Mice; Motor Activity; Neurogenesis; Proliferating Cell Nuclear Antigen; Rats; Rats, Sprague-Dawley; Recovery of Function; Time Factors; Toluene; Tumor Suppressor Protein p53; Up-Regulation	2009
Cytotoxicity and mitochondrial apoptosis induced by etoposide in melanoma cells. Cancer investigation, 2009, Volume: 27, Issue:7 Topics: Adenosine Triphosphate; Antineoplastic Agents, Phytogenic; Apoptosis; Ataxia Telangiectasia Mutated Proteins; bcl-2-Associated X Protein; Benzothiazoles; Caspase 2; Caspase 3; Caspase 9; Caspase Inhibitors; Cell Cycle Proteins; Cyclosporine; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; DNA Damage; DNA-Binding Proteins; Etoposide; Humans; Melanoma; Mitochondria; Neoplasm Proteins; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Superoxides; Toluene; Tumor Cells, Cultured; Tumor Suppressor Protein p53; Tumor Suppressor Proteins	2009
Axin induces cell death and reduces cell proliferation in astrocytoma by activating the p53 pathway. International journal of oncology, 2009, Volume: 35, Issue:1 Topics: Adolescent; Adult; Aged; Animals; Apoptosis; Astrocytoma; Axin Protein; Benzothiazoles; Brain Neoplasms; Cell Line, Tumor; Cell Proliferation; Child; Child, Preschool; Cyclin D1; Cyclin-Dependent Kinase Inhibitor p21; Female; Glioblastoma; Humans; Immunohistochemistry; Male; Middle Aged; Neoplasm Staging; Rats; Repressor Proteins; Reverse Transcriptase Polymerase Chain Reaction; RNA Interference; Time Factors; Toluene; Transfection; Tumor Suppressor Protein p53; Young Adult	2009
Fusarial toxin-induced toxicity in cultured cells and in isolated mitochondria involves PTPC-dependent activation of the mitochondrial pathway of apoptosis. Toxicological sciences : an official journal of the Society of Toxicology, 2009, Volume: 110, Issue:2 Topics: Animals; Apoptosis; bcl-2-Associated X Protein; bcl-X Protein; Benzothiazoles; Caspase 3; Cell Survival; Cytochromes c; Dose-Response Relationship, Drug; Female; Fusarium; HCT116 Cells; HeLa Cells; Humans; Membrane Potential, Mitochondrial; Mice; Mice, Inbred C57BL; Mitochondria; Mitochondria, Liver; Mitochondrial Membrane Transport Proteins; Mitochondrial Permeability Transition Pore; Proto-Oncogene Proteins c-bcl-2; Signal Transduction; Superoxides; T-2 Toxin; Time Factors; Toluene; Tumor Suppressor Protein p53; Zearalenone	2009
Role of p53 in human chondrocyte apoptosis in response to shear strain. Arthritis and rheumatism, 2009, Volume: 60, Issue:8 Topics: Apoptosis; Apoptosis Regulatory Proteins; Benzothiazoles; Cell Count; Cell Fractionation; Chondrocytes; Comet Assay; DNA Damage; DNA Fragmentation; Gene Expression; Gene Silencing; Humans; RNA, Small Interfering; Stress, Mechanical; Toluene; Transfection; Tumor Suppressor Protein p53; Up-Regulation	2009
NF-kappab facilitates oridonin-induced apoptosis and autophagy in HT1080 cells through a p53-mediated pathway. Archives of biochemistry and biophysics, 2009, Volume: 489, Issue:1-2 Topics: Antioxidants; Apoptosis; Apoptosis Regulatory Proteins; Autophagy; Beclin-1; Benzothiazoles; Cell Line, Tumor; Diterpenes, Kaurane; Humans; Membrane Proteins; Microtubule-Associated Proteins; NF-kappa B; Proline; Thiocarbamates; Time Factors; Toluene; Tumor Suppressor Protein p53	2009
Signalling pathways involved in 1-nitropyrene (1-NP)-induced and 3-nitrofluoranthene (3-NF)-induced cell death in Hepa1c1c7 cells. Mutagenesis, 2009, Volume: 24, Issue:6 Topics: Apoptosis; Apoptosis Inducing Factor; Ataxia Telangiectasia Mutated Proteins; Benzothiazoles; Cell Cycle Proteins; Cell Death; Cell Line, Tumor; Cell Nucleus; Checkpoint Kinase 1; Checkpoint Kinase 2; DNA Damage; DNA-Binding Proteins; Endodeoxyribonucleases; Fluorenes; Histones; Humans; Protein Kinases; Protein Serine-Threonine Kinases; Pyrenes; Toluene; Tumor Suppressor Protein p53; Tumor Suppressor Proteins	2009
Enhanced sensitivity of celecoxib in human glioblastoma cells: Induction of DNA damage leading to p53-dependent G1 cell cycle arrest and autophagy. Molecular cancer, 2009, Aug-25, Volume: 8 Topics: Analysis of Variance; Autophagy; Benzothiazoles; Blotting, Western; Celecoxib; Cell Line, Tumor; Cell Proliferation; Cell Survival; Comet Assay; Cyclin-Dependent Kinase Inhibitor p21; Cyclooxygenase Inhibitors; DNA Damage; Dose-Response Relationship, Drug; G1 Phase; Humans; Immunohistochemistry; Pyrazoles; Resting Phase, Cell Cycle; Reverse Transcriptase Polymerase Chain Reaction; Sulfonamides; Toluene; Tumor Suppressor Protein p53	2009
Doxorubicin induces senescence or apoptosis in rat neonatal cardiomyocytes by regulating the expression levels of the telomere binding factors 1 and 2. American journal of physiology. Heart and circulatory physiology, 2009, Volume: 297, Issue:6 Topics: Animals; Animals, Newborn; Anthracenes; Antibiotics, Antineoplastic; Apoptosis; bcl-2-Associated X Protein; Benzothiazoles; Cells, Cultured; Cellular Senescence; Checkpoint Kinase 2; Cytoskeleton; Dose-Response Relationship, Drug; Doxorubicin; Imidazoles; JNK Mitogen-Activated Protein Kinases; Mitosis; Myocytes, Cardiac; p38 Mitogen-Activated Protein Kinases; Phenotype; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins c-bcl-2; Pyridines; Rats; Rats, Sprague-Dawley; RNA Interference; Telomeric Repeat Binding Protein 1; Telomeric Repeat Binding Protein 2; Time Factors; Toluene; Tumor Suppressor Protein p53	2009
Use of pifithrin to inhibit p53-mediated signalling of TNF in dystrophic muscles of mdx mice. Molecular and cellular biochemistry, 2010, Volume: 337, Issue:1-2 Topics: Animals; Benzothiazoles; Cell Death; Cell Differentiation; Cell Nucleus; Cells, Cultured; Female; Mice; Mice, Inbred C57BL; Mice, Inbred mdx; Models, Biological; Muscular Dystrophy, Animal; Myoblasts, Skeletal; Signal Transduction; Toluene; Tumor Necrosis Factor-alpha; Tumor Suppressor Protein p53; Ultraviolet Rays	2010
Reduced hippocampal damage and epileptic seizures after status epilepticus in mice lacking proapoptotic Puma. FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2010, Volume: 24, Issue:3 Topics: Animals; Apoptosis Regulatory Proteins; Benzothiazoles; Blotting, Western; Epilepsy; Genotype; Hippocampus; Male; Mice; Mice, Inbred C57BL; Mice, Mutant Strains; Polymerase Chain Reaction; Signal Transduction; Status Epilepticus; Toluene; Tumor Suppressor Protein p53; Tumor Suppressor Proteins	2010
Activation of p53 promotes renal injury in acute aristolochic acid nephropathy. Journal of the American Society of Nephrology : JASN, 2010, Volume: 21, Issue:1 Topics: Animals; Apoptosis; Aristolochic Acids; Benzothiazoles; Cells, Cultured; Disease Models, Animal; Dose-Response Relationship, Drug; Epithelial Cells; Kidney Tubular Necrosis, Acute; Kidney Tubules; Mice; Mice, Inbred C57BL; Mice, Knockout; Phosphorylation; STAT3 Transcription Factor; Toluene; Tumor Suppressor Protein p53	2010
Inhibiting p53 pathways in microglia attenuates microglial-evoked neurotoxicity following exposure to Alzheimer peptides. Journal of neurochemistry, 2010, Volume: 112, Issue:2 Topics: Adjuvants, Immunologic; Amyloid beta-Peptides; Animals; Animals, Newborn; Apoptosis; Benzothiazoles; Cells, Cultured; Cerebellum; Chromogranin A; Drug Interactions; Enzyme-Linked Immunosorbent Assay; Lithium Chloride; Microglia; Neurons; Peptide Fragments; Polysaccharides; Rats; Rats, Wistar; Signal Transduction; Time Factors; Toluene; Transcription Factor CHOP; Tumor Necrosis Factor-alpha; Tumor Suppressor Protein p53	2010
PFT-alpha inhibits antibody-induced activation of p53 and pro-apoptotic signaling in 1-LN prostate cancer cells. Biochemical and biophysical research communications, 2010, Jan-01, Volume: 391, Issue:1 Topics: Antibodies, Neoplasm; Apoptosis; Apoptosis Regulatory Proteins; Autoantibodies; Benzothiazoles; Caspases; Cell Line, Tumor; Endoplasmic Reticulum Chaperone BiP; Heat-Shock Proteins; Humans; Male; Prostatic Neoplasms; Toluene; Tumor Suppressor Protein p53	2010
Short-term inhibition of p53 combined with keratinocyte growth factor improves thymic epithelial cell recovery and enhances T-cell reconstitution after murine bone marrow transplantation. Blood, 2010, Feb-04, Volume: 115, Issue:5 Topics: Adaptive Immunity; Animals; Apoptosis Regulatory Proteins; Bcl-2-Like Protein 11; Benzothiazoles; Bone Marrow Cells; Bone Marrow Transplantation; Chemokine CCL21; Epithelial Cells; Female; Fibroblast Growth Factor 7; Fluorescent Antibody Technique; Listeria monocytogenes; Liver; Male; Membrane Proteins; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Knockout; Proto-Oncogene Proteins; Spleen; T-Lymphocytes; Thymus Gland; Time Factors; Toluene; Tumor Suppressor Protein p53	2010
Transcriptional regulation of the presenilin-1 gene controls gamma-secretase activity. Frontiers in bioscience (Elite edition), 2010, 01-01, Volume: 2, Issue:1 Topics: Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Amyloid Precursor Protein Secretases; Analysis of Variance; Anthracenes; Benzothiazoles; Blotting, Western; Cell Line, Tumor; Chromatin Immunoprecipitation; DNA Primers; Enzyme-Linked Immunosorbent Assay; Gene Expression Regulation; Genetic Vectors; Humans; JNK Mitogen-Activated Protein Kinases; Peptide Fragments; Presenilin-1; Reverse Transcriptase Polymerase Chain Reaction; Toluene	2010
Sodium orthovanadate inhibits p53-mediated apoptosis. Cancer research, 2010, Jan-01, Volume: 70, Issue:1 Topics: Animals; Apoptosis; Benzothiazoles; Blotting, Western; Cell Line; Female; Flow Cytometry; Humans; Immunoprecipitation; Mice; Mice, Inbred ICR; Radiation-Protective Agents; Sulfonamides; Toluene; Transfection; Tumor Suppressor Protein p53; Vanadates	2010
p53 induction contributes to excitotoxic neuronal death in rat striatum through apoptotic and autophagic mechanisms. The European journal of neuroscience, 2009, Volume: 30, Issue:12 Topics: Adenine; Animals; Apoptosis; Autophagy; Benzothiazoles; Cell Death; Corpus Striatum; DNA Fragmentation; Genes, p53; Neurons; Neurotoxins; NF-kappa B; Peptides; Quinolinic Acid; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Toluene; Transcriptional Activation; Tumor Suppressor Protein p53	2009
Induction of p53-independent apoptosis by a novel synthetic hexahydrocannabinol analog is mediated via Sp1-dependent NSAID-activated gene-1 in colon cancer cells. Biochemical pharmacology, 2010, Jul-01, Volume: 80, Issue:1 Topics: Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents; Apoptosis; Benzothiazoles; Colonic Neoplasms; Dronabinol; Genes, p53; HCT116 Cells; HT29 Cells; Humans; Protein Kinases; Sulindac; Toluene; Tumor Suppressor Protein p53	2010
Relation between DNA repair, apoptosis and chromosomal aberrations in presence of pifithrin-alpha, an inhibitor of p53. Mutation research, 2010, Aug-14, Volume: 701, Issue:1 Topics: Alpha Particles; Apoptosis; Benzothiazoles; Chromosome Aberrations; DNA Repair; Humans; Linear Energy Transfer; Lymphocytes; Micronuclei, Chromosome-Defective; Neutrons; Resting Phase, Cell Cycle; Toluene; Tumor Suppressor Protein p53; X-Rays	2010
A small molecule inhibitor of p53 stimulates amplification of hematopoietic stem cells but does not promote tumor development in mice. Cell cycle (Georgetown, Tex.), 2010, Apr-01, Volume: 9, Issue:7 Topics: Animals; Benzothiazoles; Cell Proliferation; Cells, Cultured; Gamma Rays; Hematopoietic Stem Cells; Mice; Mice, Knockout; Neoplasms; Toluene; Tumor Suppressor Protein p53	2010
p53 Plays an important role in cell fate determination after exposure to microcystin-LR. Environmental health perspectives, 2010, Volume: 118, Issue:9 Topics: Apoptosis; Benzothiazoles; Cell Line; Cell Proliferation; Humans; Marine Toxins; Microcystins; Organic Anion Transporters, Sodium-Independent; Phosphorylation; Proto-Oncogene Proteins c-akt; Signal Transduction; Solute Carrier Organic Anion Transporter Family Member 1B3; Toluene; Tumor Suppressor Protein p53	2010
Inhibition of p53 sensitizes MCF-7 cells to ceramide treatment. International journal of oncology, 2010, Volume: 37, Issue:1 Topics: Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Benzothiazoles; Breast Neoplasms; Carcinoma; Cell Cycle; Cell Line, Tumor; Ceramides; Cyclin D; Cyclin E; Cyclin-Dependent Kinase Inhibitor p21; Drug Evaluation, Preclinical; Drug Synergism; Female; Gene Expression Regulation, Neoplastic; Humans; RNA, Small Interfering; Toluene; Tumor Suppressor Protein p53	2010
Molecular mechanisms of nutlin-induced apoptosis in multiple myeloma: evidence for p53-transcription-dependent and -independent pathways. Cancer biology & therapy, 2010, Sep-15, Volume: 10, Issue:6 Topics: Apoptosis; Apoptosis Regulatory Proteins; Benzothiazoles; Cell Line, Tumor; Cell Proliferation; Cell Survival; Cyclin-Dependent Kinase Inhibitor p21; Dose-Response Relationship, Drug; Flow Cytometry; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Humans; Imidazoles; Immunoblotting; Multiple Myeloma; Piperazines; Protein Binding; Protein Transport; Proto-Oncogene Proteins c-bcl-2; Proto-Oncogene Proteins c-mdm2; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Sulfonamides; Toluene; Transcription, Genetic; Tumor Suppressor Protein p53	2010
Enhanced Gadd45 expression and delayed G2/M progression are p53-dependent in zinc-supplemented human bronchial epithelial cells. Experimental biology and medicine (Maywood, N.J.), 2010, Volume: 235, Issue:8 Topics: Benzothiazoles; Bronchi; CDC2 Protein Kinase; Cells, Cultured; Cyclin B1; Dose-Response Relationship, Drug; Epithelial Cells; G2 Phase; GADD45 Proteins; Gene Expression Regulation; Humans; Intracellular Signaling Peptides and Proteins; Mitosis; RNA, Messenger; Toluene; Tumor Suppressor Protein p53; Zinc	2010
Pifithrin-α as a potential cytoprotective agent in radiotherapy: protection of normal tissue without decreasing therapeutic efficacy in glioma cells. Radiation research, 2010, Volume: 174, Issue:5 Topics: Animals; Astrocytes; Benzothiazoles; Cell Line, Tumor; Cytoprotection; Fibroblasts; G1 Phase; Gene Expression Regulation, Neoplastic; Glioma; Humans; Radiation Injuries; Radiation Tolerance; Rats; Toluene; Tumor Suppressor Protein p53	2010
Senescence and dysfunction of proximal tubular cells are associated with activated p53 expression by indoxyl sulfate. American journal of physiology. Cell physiology, 2010, Volume: 299, Issue:5 Topics: Acetylcysteine; Animals; Benzothiazoles; Cell Line; Cell Proliferation; Cellular Senescence; Fibrosis; Humans; Indican; Kidney Failure, Chronic; Kidney Tubules, Proximal; Male; Random Allocation; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Toluene; Tumor Suppressor Protein p53	2010
Hypoxia downregulates p53 but induces apoptosis and enhances expression of BAD in cultures of human syncytiotrophoblasts. American journal of physiology. Cell physiology, 2010, Volume: 299, Issue:5 Topics: Animals; Apoptosis; bcl-Associated Death Protein; Benzothiazoles; Cells, Cultured; Down-Regulation; Enzyme Inhibitors; Female; Gene Expression Regulation; Humans; Hypoxia; Imidazoles; Oxygen; Piperazines; Pregnancy; Staurosporine; Toluene; Trophoblasts; Tumor Suppressor Protein p53	2010
Haploinsufficiency for ribosomal protein genes causes selective activation of p53 in human erythroid progenitor cells. Blood, 2011, Mar-03, Volume: 117, Issue:9 Topics: Anemia, Diamond-Blackfan; Anemia, Macrocytic; Animals; Benzothiazoles; Cell Cycle; Cell Lineage; Cell Nucleolus; Chromosome Deletion; Chromosomes, Human, Pair 5; Cyclin-Dependent Kinase Inhibitor p21; Erythroid Precursor Cells; Haploinsufficiency; Hematopoiesis; Humans; Imidazoles; Mice; Mice, Inbred BALB C; Myelodysplastic Syndromes; Piperazines; Protein Binding; Proto-Oncogene Proteins c-mdm2; Ribosomal Proteins; RNA, Small Interfering; Toluene; Tumor Suppressor Protein p53	2011
Pifithrin-α, an inhibitor of p53 transactivation, up-regulates COX-2 expression through an MAPK-dependent pathway. Pharmacology, 2010, Volume: 86, Issue:5-6 Topics: Benzothiazoles; Breast Neoplasms; Cell Line, Tumor; Cells, Cultured; Cyclooxygenase 2; Dose-Response Relationship, Drug; Extracellular Signal-Regulated MAP Kinases; Female; Fibroblasts; Humans; MAP Kinase Kinase Kinases; Mitogen-Activated Protein Kinases; Phosphorylation; Toluene; Tumor Suppressor Protein p53; Up-Regulation	2010
Inhibition of p53 after acute myocardial infarction: reduction of apoptosis is counteracted by disturbed scar formation and cardiac rupture. Journal of molecular and cellular cardiology, 2011, Volume: 50, Issue:3 Topics: Animals; Apoptosis; Benzothiazoles; Cell Proliferation; Cells, Cultured; Collagen; Heart Rupture; Hydrogen Peroxide; Male; Matrix Metalloproteinase 2; Mice; Myocardial Infarction; Myocytes, Cardiac; Rats; Toluene; Transcriptional Activation; Tumor Suppressor Protein p53	2011
Mechanism of anthracycline-mediated down-regulation of GATA4 in the heart. Cardiovascular research, 2011, Apr-01, Volume: 90, Issue:1 Topics: Animals; Antibiotics, Antineoplastic; Base Sequence; Benzothiazoles; Binding Sites; CCAAT-Binding Factor; Cell Line; Daunorubicin; Down-Regulation; GATA4 Transcription Factor; Male; Mice; Mice, Inbred C57BL; Molecular Sequence Data; Myocytes, Cardiac; Perfusion; Promoter Regions, Genetic; Time Factors; Toluene; Transcription, Genetic; Transfection; Tumor Suppressor Protein p53	2011
Mild thermotolerance induced at 40°C protects HeLa cells against activation of death receptor-mediated apoptosis by hydrogen peroxide. Free radical biology & medicine, 2011, Mar-15, Volume: 50, Issue:6 Topics: Apoptosis; Benzothiazoles; BH3 Interacting Domain Death Agonist Protein; Caspases; Catalase; Cell Membrane; Chromatin; Fas Ligand Protein; fas Receptor; Fas-Associated Death Domain Protein; Flow Cytometry; Genes, p53; HeLa Cells; Humans; Hydrogen Peroxide; Mitochondria; Oxidative Stress; Polyethylene Glycols; Reactive Oxygen Species; Receptors, Death Domain; Temperature; Toluene	2011
p53-Mediated oxidative stress and tubular injury in rats with glycerol-induced acute kidney injury. American journal of nephrology, 2011, Volume: 33, Issue:1 Topics: Acute Kidney Injury; Animals; Apoptosis; Benzothiazoles; Caspase 3; Glycerol; In Situ Nick-End Labeling; Kidney; Kidney Tubules; Oxidative Stress; Rats; Rats, Wistar; Toluene; Transcription, Genetic; Tumor Suppressor Protein p53	2011
Human mesenchymal stem cells are sensitive to abnormal gravity and exhibit classic apoptotic features. Acta biochimica et biophysica Sinica, 2011, Volume: 43, Issue:2 Topics: Adult; Apoptosis; Benzothiazoles; Caspase 3; Caspase 7; Cell Survival; Cells, Cultured; Cytoskeleton; Electromagnetic Fields; Gravitation; Humans; Hypergravity; Hypogravity; Mesenchymal Stem Cells; Stress Fibers; Toluene; Tubulin; Tumor Suppressor Protein p53	2011
Blocking NF-κB nuclear translocation leads to p53-related autophagy activation and cell apoptosis. World journal of gastroenterology, 2011, Jan-28, Volume: 17, Issue:4 Topics: Active Transport, Cell Nucleus; Antineoplastic Agents; Apoptosis; Autophagy; Benzothiazoles; Cell Line, Tumor; Humans; NF-kappa B; Peptides; Stomach Neoplasms; Toluene; Tumor Suppressor Protein p53	2011
PUMA mediates the apoptotic signal of hypoxia/reoxygenation in cardiomyocytes through mitochondrial pathway. Shock (Augusta, Ga.), 2011, Volume: 35, Issue:6 Topics: Animals; Apoptosis; Apoptosis Regulatory Proteins; Benzothiazoles; Caspase 3; Caspase 8; Cells, Cultured; Cytochromes c; Hypoxia; Membrane Potential, Mitochondrial; Mitochondria, Heart; Muscle Proteins; Myocytes, Cardiac; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Toluene	2011
Enhanced survival of dopaminergic neuronal transplants in hemiparkinsonian rats by the p53 inactivator PFT-α. Cell transplantation, 2011, Volume: 20, Issue:9 Topics: Animals; Behavior, Animal; Benzothiazoles; Brain Tissue Transplantation; Cell Count; Cell Survival; Dopaminergic Neurons; In Situ Nick-End Labeling; Male; Parkinson Disease; Rats; Rats, Sprague-Dawley; Substantia Nigra; Toluene; Tumor Suppressor Protein p53; Tyrosine 3-Monooxygenase	2011
Synthesis and biological evaluation of imidazolo[2,1-b]benzothiazole derivatives, as potential p53 inhibitors. Bioorganic & medicinal chemistry, 2011, Mar-01, Volume: 19, Issue:5 Topics: Animals; Antineoplastic Agents; Benzothiazoles; Cell Line, Tumor; Disease Models, Animal; Female; Gene Expression Regulation; Humans; Inhibitory Concentration 50; Ovarian Neoplasms; Toluene; Transplantation, Heterologous; Tumor Suppressor Protein p53	2011
Distinct regulation of p53-mediated apoptosis by protein kinase Cα, δ, ε and ζ: Evidence in yeast for transcription-dependent and -independent p53 apoptotic mechanisms. Experimental cell research, 2011, May-01, Volume: 317, Issue:8 Topics: Animals; Apoptosis; Benzothiazoles; Cattle; Gene Expression Regulation, Fungal; Humans; Hydrogen Peroxide; Mice; Mitochondria; Oxidants; Protein Kinase C; Protein Kinase C-alpha; Protein Kinase C-delta; Protein Kinase C-epsilon; Rats; Reactive Oxygen Species; Saccharomyces cerevisiae; Toluene; Transcription, Genetic; Tumor Suppressor Protein p53	2011
Biological and chemical studies on aryl hydrocarbon receptor induction by the p53 inhibitor pifithrin-α and its condensation product pifithrin-β. Life sciences, 2011, Apr-25, Volume: 88, Issue:17-18 Topics: Animals; Benzothiazoles; Cell Line; Cytochrome P-450 CYP1A1; Dose-Response Relationship, Drug; Fibroblasts; Heterocyclic Compounds, 4 or More Rings; Oncorhynchus mykiss; Polymerase Chain Reaction; Rats; Receptors, Aryl Hydrocarbon; Toluene; Tumor Suppressor Protein p53	2011
Inhibition of p53-p21 pathway promotes the differentiation of rat bone marrow mesenchymal stem cells into cardiomyocytes. Molecular and cellular biochemistry, 2011, Volume: 354, Issue:1-2 Topics: Animals; Apoptosis; Azacitidine; Benzothiazoles; Bone Marrow Cells; Cell Proliferation; Cells, Cultured; Cyclin-Dependent Kinase Inhibitor p21; Decitabine; Down-Regulation; Leukocyte Common Antigens; Male; Mesenchymal Stem Cells; Myocytes, Cardiac; Rats; Rats, Sprague-Dawley; Toluene; Tumor Suppressor Protein p53	2011
Id1-induced inhibition of p53 facilitates endothelial cell migration and tube formation by regulating the expression of beta1-integrin. Molecular and cellular biochemistry, 2011, Volume: 357, Issue:1-2 Topics: Benzothiazoles; Cell Movement; Cytoskeleton; Endothelial Cells; Gene Expression Regulation; Gene Silencing; Human Umbilical Vein Endothelial Cells; Humans; Inhibitor of Differentiation Protein 1; Integrin beta1; Neovascularization, Physiologic; Phosphorylation; Signal Transduction; Toluene; Tumor Suppressor Protein p53	2011
Transcriptional and post-transcriptional mechanisms for oncogenic overexpression of ether à go-go K+ channel. PloS one, 2011, Volume: 6, Issue:5 Topics: Benzothiazoles; Blotting, Western; Cell Line, Tumor; Cell Proliferation; Chromatin Immunoprecipitation; E2F1 Transcription Factor; Electrophoretic Mobility Shift Assay; Ether-A-Go-Go Potassium Channels; Humans; Imidazoles; MicroRNAs; Oligodeoxyribonucleotides, Antisense; Piperazines; Reverse Transcriptase Polymerase Chain Reaction; Toluene; Tumor Suppressor Protein p53	2011
Targeting the p53 pathway to protect the neonatal ischemic brain. Annals of neurology, 2011, Volume: 70, Issue:2 Topics: Animals; Animals, Newborn; Apoptosis; Benzothiazoles; Biomarkers; Brain; Hypoxia-Ischemia, Brain; Mitochondria; Neuroprotective Agents; Oxidative Stress; Rats; Rats, Wistar; Toluene; Treatment Outcome; Tumor Suppressor Protein p53	2011
NF-κB plays an important role in indoxyl sulfate-induced cellular senescence, fibrotic gene expression, and inhibition of proliferation in proximal tubular cells. American journal of physiology. Cell physiology, 2011, Volume: 301, Issue:5 Topics: Actins; Acute Kidney Injury; Animals; Benzothiazoles; beta-Galactosidase; Cell Line; Cell Proliferation; Cellular Senescence; Cyclin-Dependent Kinase Inhibitor p21; Humans; Indican; Kidney Tubules, Proximal; Male; NF-kappa B; Promoter Regions, Genetic; Pyrrolidines; Rats; Rats, Sprague-Dawley; RNA, Small Interfering; Sesquiterpenes; Thiocarbamates; Toluene; Transforming Growth Factor beta1; Tumor Suppressor Protein p53	2011
Autophagy impairment induces premature senescence in primary human fibroblasts. PloS one, 2011, Volume: 6, Issue:8 Topics: Acetylcysteine; Adaptor Proteins, Signal Transducing; Autophagy; Autophagy-Related Protein 12; Autophagy-Related Protein 7; Benzothiazoles; beta-Galactosidase; Blotting, Western; Cell Cycle Proteins; Cells, Cultured; Cellular Senescence; Child; Fibroblasts; Humans; Lysosomal Membrane Proteins; Lysosomal-Associated Membrane Protein 2; Male; Microscopy, Electron; Phosphoproteins; Primary Cell Culture; Reactive Oxygen Species; Ribosomal Protein S6 Kinases, 70-kDa; RNA Interference; Sequestosome-1 Protein; Signal Transduction; Small Ubiquitin-Related Modifier Proteins; Time Factors; Toluene; TOR Serine-Threonine Kinases; Tumor Suppressor Protein p53; Ubiquitin-Activating Enzymes	2011
Classification of polycyclic aromatic hydrocarbons based on mutagenicity in lung tissue through DNA microarray. Environmental toxicology, 2013, Volume: 28, Issue:11 Topics: Aryl Hydrocarbon Hydroxylases; Benzoflavones; Benzothiazoles; Cell Line; DNA Damage; Environmental Pollutants; Gene Expression Profiling; Gene Expression Regulation; Gene Ontology; Genes, p53; Humans; Lung; Mutagenicity Tests; Oligonucleotide Array Sequence Analysis; Polycyclic Aromatic Hydrocarbons; Pulmonary Alveoli; Respiratory Mucosa; Toluene	2013
Study on X-ray-induced apoptosis and chromosomal damage in G2 human lymphocytes in the presence of pifithrin-α, an inhibitor of p53. Mutation research, 2011, Nov-27, Volume: 726, Issue:1 Topics: Apoptosis; Benzothiazoles; Cells, Cultured; Chromosome Aberrations; DNA Repair; G2 Phase; Humans; Lymphocytes; Toluene; Tumor Suppressor Protein p53; X-Rays	2011
[Effects of hot shock protein 70 inhibitor PFTµ on inflammatory response in lipopolysaccharide-stimulated RAW264.7 cells and mice underwent myocardial ischemia-reperfusion injury]. Zhonghua xin xue guan bing za zhi, 2011, Volume: 39, Issue:6 Topics: Animals; Benzothiazoles; Cell Line; HSP70 Heat-Shock Proteins; Inflammation; Lipopolysaccharides; Macrophages; Male; Mice; Mice, Inbred C57BL; Myocardial Reperfusion Injury; Myocardium; Nitric Oxide; Nitric Oxide Synthase Type II; Toluene	2011
High dose of pyridoxine induces IGFBP-3 mRNA expression in MCF-7 cells and its induction is inhibited by the p53-specific inhibitor pifithrin-α. Journal of nutritional science and vitaminology, 2011, Volume: 57, Issue:4 Topics: Acetonitriles; Antineoplastic Agents; Apoptosis; Benzothiazoles; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Dietary Supplements; Dose-Response Relationship, Drug; Female; Gene Expression; Humans; Imidazoles; Insulin-Like Growth Factor Binding Protein 3; Mitogen-Activated Protein Kinases; Oligonucleotide Array Sequence Analysis; Pyridoxine; Real-Time Polymerase Chain Reaction; RNA, Messenger; Toluene; Tumor Suppressor Protein p53; Vitamin B Complex	2011
The p53 inhibitor pifithrin-α can stimulate fibrosis in a rat model of ischemic acute kidney injury. American journal of physiology. Renal physiology, 2012, Jan-15, Volume: 302, Issue:2 Topics: Acute Kidney Injury; Animals; Benzothiazoles; Fibrosis; Ischemia; Kidney; Male; Rats; Rats, Sprague-Dawley; Toluene; Tumor Suppressor Protein p53	2012
Moderate dietary restriction reduces p53-mediated neurovascular damage and microglia activation after hypoxic ischemia in neonatal brain. Stroke, 2012, Volume: 43, Issue:2 Topics: Animals; Animals, Newborn; Apoptosis; Benzothiazoles; Blood-Brain Barrier; Blotting, Western; Body Weight; Brain; Brain Ischemia; Caloric Restriction; Cerebral Infarction; Fluorescent Antibody Technique; Hypoxia-Ischemia, Brain; Immunohistochemistry; In Situ Nick-End Labeling; Macrophage Activation; Maze Learning; Microglia; Rats; Rats, Sprague-Dawley; Toluene; Tumor Suppressor Protein p53	2012
Dual pathways of p53 mediated glucolipotoxicity-induced apoptosis of rat cardiomyoblast cell: activation of p53 proapoptosis and inhibition of Nrf2-NQO1 antiapoptosis. Metabolism: clinical and experimental, 2012, Volume: 61, Issue:4 Topics: Acetylcysteine; Animals; Apoptosis; Benzothiazoles; Cell Line; Free Radical Scavengers; Glucose; Myocytes, Cardiac; NAD(P)H Dehydrogenase (Quinone); NF-E2-Related Factor 2; Palmitic Acid; Rats; Reactive Oxygen Species; RNA, Small Interfering; Toluene; Tumor Suppressor Protein p53	2012
Geranylgeranyl transferase 1 modulates autophagy and apoptosis in human airway smooth muscle. American journal of physiology. Lung cellular and molecular physiology, 2012, Feb-15, Volume: 302, Issue:4 Topics: Alkyl and Aryl Transferases; Apoptosis; Autophagy; Benzamides; Benzothiazoles; Bronchi; Cell Survival; Cells, Cultured; Farnesyltranstransferase; Humans; Myocytes, Smooth Muscle; Primary Cell Culture; Signal Transduction; Toluene; Tumor Suppressor Protein p53	2012
Evidence for activation of mutated p53 by apigenin in human pancreatic cancer. Biochimica et biophysica acta, 2012, Volume: 1823, Issue:2 Topics: Animals; Apigenin; Apoptosis; Apoptosis Regulatory Proteins; bcl-X Protein; Benzothiazoles; Cell Line, Tumor; Dietary Supplements; Humans; Male; Mice; Mice, Nude; Mutation; Neoplasms, Experimental; Pancreatic Neoplasms; Proto-Oncogene Proteins; Toluene; Tumor Suppressor Protein p53	2012
Adenovirus-mediated expression of p33(ING1b) induces apoptosis and inhibits proliferation in gastric adenocarcinoma cells in vitro. Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association, 2012, Volume: 15, Issue:4 Topics: Adenocarcinoma; Adenoviridae; Apoptosis; Benzothiazoles; Cell Line, Tumor; Down-Regulation; Epithelial Cells; G1 Phase Cell Cycle Checkpoints; Gene Expression Regulation, Neoplastic; Humans; Inhibitor of Growth Protein 1; Intracellular Signaling Peptides and Proteins; Nuclear Proteins; Recombinant Proteins; Stomach Neoplasms; Toluene; Tumor Suppressor Proteins	2012
[Involvement of p38-p53 signal pathway in resveratrol-induced apoptosis in MCF-7 cells]. Yao xue xue bao = Acta pharmaceutica Sinica, 2011, Volume: 46, Issue:11 Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Benzothiazoles; Cell Proliferation; Dose-Response Relationship, Drug; Enzyme Inhibitors; Humans; Imidazoles; MCF-7 Cells; p38 Mitogen-Activated Protein Kinases; Pyridines; Resveratrol; Signal Transduction; Stilbenes; Toluene; Tumor Suppressor Protein p53	2011
P53 activation plays a crucial role in silibinin induced ROS generation via PUMA and JNK. Free radical research, 2012, Volume: 46, Issue:3 Topics: Anthracenes; Apoptosis; Apoptosis Regulatory Proteins; Benzothiazoles; Carcinoma, Squamous Cell; Cell Line, Tumor; Female; Gene Expression Regulation, Neoplastic; Genes, p53; HeLa Cells; Humans; JNK Mitogen-Activated Protein Kinases; MAP Kinase Signaling System; Membrane Potential, Mitochondrial; Oxidative Stress; Phosphorylation; Protein Processing, Post-Translational; Proto-Oncogene Proteins; Reactive Oxygen Species; Silybin; Silymarin; Toluene; Tumor Suppressor Protein p53; Vulvar Neoplasms	2012
Insulin increases epiblast cell number of in vitro cultured mouse embryos via the PI3K/GSK3/p53 pathway. Stem cells and development, 2012, Sep-01, Volume: 21, Issue:13 Topics: Animals; Benzothiazoles; Cell Count; Chromones; Culture Media; Embryo Culture Techniques; Embryo, Mammalian; Embryonic Development; Embryonic Stem Cells; Enzyme Activation; Female; Germ Layers; Glycogen Synthase Kinase 3; Homeodomain Proteins; Immunohistochemistry; Insulin; Isoquinolines; Male; Mice; Mice, Inbred C57BL; Morpholines; Nanog Homeobox Protein; Octamer Transcription Factor-3; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Pyridines; Pyrimidines; Receptor, Insulin; Signal Transduction; Sulfonamides; Toluene; Transcription, Genetic; Tumor Suppressor Protein p53	2012
Functional characterization of the p53 binding site in the human PYNOD promoter. Human immunology, 2012, Volume: 73, Issue:4 Topics: Adaptor Proteins, Signal Transducing; Apoptosis Regulatory Proteins; Base Sequence; Benzothiazoles; Binding Sites; Carrier Proteins; Cell Line; Gene Expression; Gene Order; Humans; Nucleotide Motifs; Promoter Regions, Genetic; Recombination, Genetic; RNA, Messenger; Sequence Deletion; Toluene; Tumor Suppressor Protein p53	2012
Direct induction of apoptosis using an optimal mitochondrially targeted p53. Molecular pharmaceutics, 2012, May-07, Volume: 9, Issue:5 Topics: Animals; Apoptosis; bcl-2-Associated X Protein; Benzothiazoles; Cell Line; In Situ Nick-End Labeling; Mice; Mitochondria; Plasmids; Sulfonamides; Toluene; Transfection; Tumor Suppressor Protein p53	2012
XPD could suppress growth of HepG2.2.15 and down-regulate the expression of hepatitis B virus x protein through P53 pathway. Biochemical and biophysical research communications, 2012, Mar-23, Volume: 419, Issue:4 Topics: bcl-2-Associated X Protein; Benzothiazoles; Carcinoma, Hepatocellular; Cell Proliferation; Cell Survival; Down-Regulation; Hep G2 Cells; Humans; Liver Neoplasms; Proto-Oncogene Proteins c-bcl-2; Proto-Oncogene Proteins p21(ras); Toluene; Trans-Activators; Tumor Suppressor Protein p53; Viral Regulatory and Accessory Proteins; Xeroderma Pigmentosum Group D Protein	2012
p53-induced uncoupling expression of aquaporin-4 and inwardly rectifying K+ 4.1 channels in cytotoxic edema after subarachnoid hemorrhage. CNS neuroscience & therapeutics, 2012, Volume: 18, Issue:4 Topics: Animals; Aquaporin 4; Benzothiazoles; Brain Edema; Gene Expression Regulation; Hippocampus; Male; Potassium Channels, Inwardly Rectifying; Rats; Rats, Sprague-Dawley; Subarachnoid Hemorrhage; Toluene; Tumor Suppressor Protein p53	2012
Generation of induced pluripotent stem cells from buffalo (Bubalus bubalis) fetal fibroblasts with buffalo defined factors. Stem cells and development, 2012, Sep-01, Volume: 21, Issue:13 Topics: Animals; Antigens, Polyomavirus Transforming; Benzothiazoles; Biomarkers; Blastocyst; Buffaloes; Cadherins; Cell Differentiation; Cell Proliferation; Cells, Cultured; DNA Methylation; Embryoid Bodies; Epigenesis, Genetic; Fetus; Fibroblasts; Genetic Vectors; Germ Layers; Induced Pluripotent Stem Cells; Kruppel-Like Factor 4; Kruppel-Like Transcription Factors; Mice; Mice, Inbred BALB C; Mice, Nude; Nuclear Transfer Techniques; Octamer Transcription Factor-3; Open Reading Frames; Promoter Regions, Genetic; Proto-Oncogene Proteins c-myc; Simian virus 40; SOXB1 Transcription Factors; Teratoma; Toluene; Tumor Suppressor Protein p53	2012
MicroRNA-34a upregulation during seizure-induced neuronal death. Cell death & disease, 2012, Mar-22, Volume: 3 Topics: Animals; Apoptosis; Argonaute Proteins; Benzothiazoles; Hippocampus; Immunoprecipitation; Kainic Acid; Male; Mice; Mice, Inbred C57BL; MicroRNAs; Protein Binding; Seizures; Toluene; Tumor Suppressor Protein p53; Up-Regulation	2012
The p53 inhibitor, pifithrin-α, suppresses self-renewal of embryonic stem cells. Biochemical and biophysical research communications, 2012, Apr-13, Volume: 420, Issue:3 Topics: Animals; Benzothiazoles; Cell Line; Cell Proliferation; Cell Survival; Cyclin D1; Embryonic Stem Cells; Homeodomain Proteins; Mice; Nanog Homeobox Protein; Toluene; Transcriptional Activation; Tumor Suppressor Protein p53	2012
Novel multiple apoptotic mechanism of shikonin in human glioma cells. Annals of surgical oncology, 2012, Volume: 19, Issue:9 Topics: Acetylcysteine; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; bcl-2-Associated X Protein; Benzothiazoles; Catalase; Cell Line, Tumor; Cyclosporine; G1 Phase Cell Cycle Checkpoints; Glioma; Glutathione; Humans; Membrane Potential, Mitochondrial; Mitochondria; Naphthoquinones; Oxidative Stress; Poly(ADP-ribose) Polymerases; Proto-Oncogene Proteins c-bcl-2; Reactive Oxygen Species; Superoxide Dismutase; Superoxide Dismutase-1; Toluene; Tumor Suppressor Protein p53	2012
Expression of the polyalanine expansion mutant of nuclear poly(A)-binding protein induces apoptosis via the p53 pathway. Cell biology international, 2012, Aug-01, Volume: 36, Issue:8 Topics: Apoptosis; Apoptosis Regulatory Proteins; bcl-2-Associated X Protein; Benzothiazoles; Caspase 3; Cytochromes c; HEK293 Cells; HeLa Cells; Humans; Mitochondria; Muscular Dystrophy, Oculopharyngeal; Mutation; Peptides; Poly(A)-Binding Protein II; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Toluene; Tumor Suppressor Protein p53; Up-Regulation	2012
The synthetic purine reversine selectively induces cell death of cancer cells. Journal of cellular biochemistry, 2012, Volume: 113, Issue:10 Topics: Antineoplastic Agents; Benzothiazoles; Blotting, Western; Caspases; Cell Cycle Checkpoints; Cell Death; Cell Dedifferentiation; Cell Proliferation; Cell Shape; Cell Survival; Endoreduplication; Enzyme Activation; Fibroblasts; Fibrosarcoma; Flow Cytometry; Gene Silencing; HeLa Cells; Humans; Morpholines; Purines; RNA, Small Interfering; Toluene; Tumor Suppressor Protein p53	2012
Alpha-melanocyte-stimulating hormone suppresses oxidative stress through a p53-mediated signaling pathway in human melanocytes. Molecular cancer research : MCR, 2012, Volume: 10, Issue:6 Topics: alpha-MSH; Benzothiazoles; Blotting, Western; Cells, Cultured; Cyclic AMP-Dependent Protein Kinases; DNA Damage; DNA Glycosylases; DNA Repair; DNA-(Apurinic or Apyrimidinic Site) Lyase; DNA-Activated Protein Kinase; Histones; Humans; Hydrogen Peroxide; Imidazoles; Melanocytes; Oxidants; Oxidative Stress; Phosphatidylinositol 3-Kinases; Phosphorylation; Piperazines; Receptor, Melanocortin, Type 1; RNA Interference; Signal Transduction; Toluene; Tumor Suppressor Protein p53; Ultraviolet Rays	2012
The p53-reactivating small-molecule RITA enhances cisplatin-induced cytotoxicity and apoptosis in head and neck cancer. Cancer letters, 2012, Dec-01, Volume: 325, Issue:1 Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; bcl-2-Associated X Protein; Benzothiazoles; Caspase 3; Cell Cycle Checkpoints; Cell Line, Tumor; Cisplatin; Cyclin-Dependent Kinase Inhibitor p21; Drug Synergism; Furans; G2 Phase; Head and Neck Neoplasms; Humans; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Proto-Oncogene Proteins c-mdm2; Toluene; Tumor Suppressor Protein p53; Xenograft Model Antitumor Assays	2012
Synergistic interaction between the novel histone deacetylase inhibitor ST2782 and the proteasome inhibitor bortezomib in platinum-sensitive and resistant ovarian carcinoma cells. Journal of inorganic biochemistry, 2012, Volume: 113 Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; bcl-2-Associated X Protein; Benzothiazoles; Boronic Acids; Bortezomib; Carcinoma; Caspase 3; Caspase Inhibitors; Cell Line, Tumor; Cisplatin; Drug Resistance, Neoplasm; Drug Synergism; Female; Gene Expression Regulation, Neoplastic; Histone Deacetylase Inhibitors; Histone Deacetylases; Humans; Neoplasm Proteins; Ovarian Neoplasms; Poly(ADP-ribose) Polymerase Inhibitors; Poly(ADP-ribose) Polymerases; Protease Inhibitors; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Pyrazines; Toluene; Tumor Suppressor Protein p53	2012
Hexavalent chromium induces energy metabolism disturbance and p53-dependent cell cycle arrest via reactive oxygen species in L-02 hepatocytes. Molecular and cellular biochemistry, 2012, Volume: 371, Issue:1-2 Topics: Acetylcysteine; Benzothiazoles; Carcinogens, Environmental; Cell Cycle Checkpoints; Chromium; Cyclin-Dependent Kinase 2; Dose-Response Relationship, Drug; Energy Metabolism; Environmental Pollutants; Hepatocytes; Humans; Reactive Oxygen Species; Signal Transduction; Toluene; Tumor Suppressor Protein p53	2012
p53 acts as a co-repressor to regulate keratin 14 expression during epidermal cell differentiation. PloS one, 2012, Volume: 7, Issue:7 Topics: Base Pairing; Base Sequence; Benzothiazoles; Cell Differentiation; Cells, Cultured; Co-Repressor Proteins; Epidermal Cells; Foreskin; Gene Expression Regulation; Genes, Dominant; Humans; Keratin-14; Keratinocytes; Male; Models, Biological; Molecular Sequence Data; Mutant Proteins; Phosphorylation; Promoter Regions, Genetic; Protein Binding; Sp1 Transcription Factor; Tetradecanoylphorbol Acetate; Toluene; Tumor Suppressor Protein p53; Up-Regulation	2012
Loss of p53 accelerates the complications of myelodysplastic syndrome in a NUP98-HOXD13-driven mouse model. Blood, 2012, Oct-11, Volume: 120, Issue:15 Topics: Animals; Benzothiazoles; Cell Transformation, Neoplastic; Disease Models, Animal; Female; Flow Cytometry; Haploinsufficiency; Hematopoietic Stem Cells; Humans; Leukemia, Myeloid, Acute; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Mice, Transgenic; Myelodysplastic Syndromes; Oncogene Proteins, Fusion; Survival Rate; Toluene; Tumor Suppressor Protein p53	2012
The novel p53-dependent metastatic and apoptotic pathway induced by vitexin in human oral cancer OC2 cells. Phytotherapy research : PTR, 2013, Volume: 27, Issue:8 Topics: Antineoplastic Agents, Phytogenic; Apigenin; Apoptosis; bcl-2-Associated X Protein; Benzothiazoles; Cell Line, Tumor; Cell Survival; Cyclin-Dependent Kinase Inhibitor p21; Flavonoids; Humans; Matrix Metalloproteinase 2; Mouth Neoplasms; Plasminogen Activator Inhibitor 1; PPAR gamma; Signal Transduction; Toluene; Tumor Suppressor Protein p53; Up-Regulation	2013
Sema3F downregulates p53 expression leading to axonal growth cone collapse in primary hippocampal neurons. International journal of clinical and experimental pathology, 2012, Volume: 5, Issue:7 Topics: Animals; Benzothiazoles; Cell Shape; Cells, Cultured; Dose-Response Relationship, Drug; Down-Regulation; Gene Silencing; Growth Cones; Hippocampus; Intracellular Signaling Peptides and Proteins; Nerve Tissue Proteins; Rats; Receptor Cross-Talk; RNA, Small Interfering; Toluene; Tumor Suppressor Protein p53	2012
Inhibition of p53 transactivation functionally interacts with microtubule stabilization to suppress excitotoxicity-induced axon degeneration. Biochemical and biophysical research communications, 2012, Oct-12, Volume: 427, Issue:1 Topics: Animals; Axons; Benzothiazoles; Cells, Cultured; Dynactin Complex; Glutamic Acid; Hippocampus; Microtubule-Associated Proteins; Microtubules; Mitochondria; Mitochondrial Diseases; Nerve Degeneration; Neurotoxins; Paclitaxel; Rats; Rats, Wistar; Toluene; Transcriptional Activation; Tumor Suppressor Protein p53	2012
p53 contributes to quercetin-induced apoptosis in human rheumatoid arthritis fibroblast-like synoviocytes. Inflammation, 2013, Volume: 36, Issue:2 Topics: Antioxidants; Apoptosis; Arthritis, Rheumatoid; bcl-2-Associated X Protein; Benzothiazoles; Caspase 3; Caspase 9; Cells, Cultured; Cytochromes c; DNA Fragmentation; Enzyme Activation; Fibroblasts; Humans; Membrane Potential, Mitochondrial; Phosphorylation; Proto-Oncogene Proteins c-bcl-2; Quercetin; RNA Interference; RNA, Small Interfering; Synovial Membrane; Toluene; Tumor Suppressor Protein p53	2013
Pifithrin-μ increases mitochondrial COX biogenesis and MnSOD activity in skeletal muscle of middle-aged mice. Mitochondrion, 2012, Volume: 12, Issue:6 Topics: Animals; Benzothiazoles; DNA, Mitochondrial; Electron Transport Complex IV; Mice; Muscle, Skeletal; Protein Transport; Sulfonamides; Superoxide Dismutase; Toluene; Tumor Suppressor Protein p53	2012
Involvement of PTEN in TPA-mediated p53-activation in mouse skin epidermal JB6 cells. FEBS letters, 2012, Nov-30, Volume: 586, Issue:23 Topics: Animals; bcl-2-Associated X Protein; Benzothiazoles; Mice; Protein Binding; PTEN Phosphohydrolase; Pyridines; RNA, Small Interfering; Skin; Toluene; Tumor Suppressor Protein p53	2012
Loss of CDKN2B promotes p53-dependent smooth muscle cell apoptosis and aneurysm formation. Arteriosclerosis, thrombosis, and vascular biology, 2013, Volume: 33, Issue:1 Topics: Adolescent; Adult; Aged; Animals; Aorta, Abdominal; Aortic Aneurysm, Abdominal; Apoptosis; Benzothiazoles; Bone Marrow Transplantation; Carotid Arteries; Carotid Artery Diseases; Case-Control Studies; Cell Movement; Cell Proliferation; Cells, Cultured; Child; Child, Preschool; Cyclin-Dependent Kinase Inhibitor p15; Disease Models, Animal; Gene Expression Regulation; Genotype; Humans; Infant; Infant, Newborn; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Middle Aged; Muscle, Smooth, Vascular; Neointima; Pancreatic Elastase; Phenotype; Proto-Oncogene Proteins c-mdm2; RNA Interference; Signal Transduction; Time Factors; Toluene; Transfection; Tumor Suppressor Protein p53; Young Adult	2013
Inhibition of p53 attenuates steatosis and liver injury in a mouse model of non-alcoholic fatty liver disease. Journal of hepatology, 2013, Volume: 58, Issue:4 Topics: Alanine Transaminase; Animals; Apoptosis; Benzothiazoles; Cell Line; Diet, High-Fat; Disease Models, Animal; Fatty Acids; Fatty Liver; Humans; Liver; Male; Malonyl Coenzyme A; Mice; Mice, Inbred C57BL; MicroRNAs; Models, Biological; Non-alcoholic Fatty Liver Disease; Oxidative Stress; Toluene; Triglycerides; Tumor Suppressor Protein p53; Weight Gain	2013
Maintenance of S-nitrosothiol homeostasis plays an important role in growth suppression of estrogen receptor-positive breast tumors. Breast cancer research : BCR, 2012, Dec-05, Volume: 14, Issue:6 Topics: Antineoplastic Agents, Hormonal; Antirheumatic Agents; Auranofin; Benzothiazoles; Breast Neoplasms; CD24 Antigen; Cell Proliferation; Cell Survival; Cyclin D1; Cysteine; Estradiol; Estrogen Receptor alpha; Extracellular Signal-Regulated MAP Kinases; Female; Fulvestrant; Homeostasis; Humans; Hyaluronan Receptors; MCF-7 Cells; Phosphorylation; Proto-Oncogene Proteins c-akt; RNA Interference; RNA, Messenger; RNA, Small Interfering; S-Nitrosothiols; Spheroids, Cellular; Thioredoxin-Disulfide Reductase; Toluene; Tumor Cells, Cultured; Tumor Suppressor Protein p53	2012
p53 is renoprotective after ischemic kidney injury by reducing inflammation. Journal of the American Society of Nephrology : JASN, 2013, Volume: 24, Issue:1 Topics: Acute Kidney Injury; Animals; Apoptosis; Benzothiazoles; Bone Marrow Transplantation; Chimera; Cytokines; Disease Models, Animal; Inflammation; Kidney; Kruppel-Like Factor 4; Kruppel-Like Transcription Factors; Leukocytes; Macrophages; Male; Mice; Peritonitis; Phenotype; Reperfusion Injury; Toluene; Tumor Suppressor Protein p53	2013
Pifithrin-α enhances the survival of transplanted neural stem cells in stroke rats by inhibiting p53 nuclear translocation. CNS neuroscience & therapeutics, 2013, Volume: 19, Issue:2 Topics: Animals; Benzothiazoles; Cell Nucleus; Cell Survival; Cells, Cultured; Combined Modality Therapy; Male; Neural Stem Cells; Random Allocation; Rats; Rats, Sprague-Dawley; Recovery of Function; Stem Cell Transplantation; Stroke; Toluene; Tumor Suppressor Protein p53; Up-Regulation	2013
ERK1/2 activation mediated by the nutlin‑3‑induced mitochondrial translocation of p53. International journal of oncology, 2013, Volume: 42, Issue:3 Topics: Antioxidants; Apoptosis; Benzothiazoles; Butadienes; Cell Line, Tumor; Cyclic N-Oxides; Enzyme Activation; Enzyme Inhibitors; ErbB Receptors; Humans; Imidazoles; MAP Kinase Kinase 1; MAP Kinase Kinase 2; Mitochondria; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Nitriles; Osteosarcoma; Phosphorylation; Piperazines; Protein Transport; Quinazolines; Reactive Oxygen Species; RNA Interference; RNA, Small Interfering; Toluene; Tumor Suppressor Protein p53; Tyrphostins	2013
p53 protein subcellular localization and apoptosis in rodent corneal epithelium cell culture following ultraviolet irradiation. International journal of molecular medicine, 2013, Volume: 31, Issue:3 Topics: Animals; Antibodies, Monoclonal; Apoptosis; Benzothiazoles; Cells, Cultured; Epithelium, Corneal; Immunohistochemistry; Mice; Mice, Inbred C57BL; RNA, Messenger; Toluene; Transcription, Genetic; Tumor Suppressor Protein p53; Ultraviolet Rays	2013
Indoxyl sulfate enhances p53-TGF-β1-Smad3 pathway in proximal tubular cells. American journal of nephrology, 2013, Volume: 37, Issue:2 Topics: Actins; Analysis of Variance; Animals; Benzothiazoles; Cells, Cultured; Extracellular Signal-Regulated MAP Kinases; Humans; Imidazoles; Indican; Kidney Tubules, Proximal; Male; Phosphorylation; Piperazines; Rats; Rats, Inbred Dahl; RNA, Messenger; Signal Transduction; Smad3 Protein; Toluene; Transforming Growth Factor beta1; Tumor Suppressor Protein p53; Up-Regulation	2013
Pifithrin-α, a pharmacological inhibitor of p53, downregulates lipopolysaccharide-induced nitric oxide production via impairment of the MyD88-independent pathway. International immunopharmacology, 2013, Volume: 15, Issue:4 Topics: Animals; Benzothiazoles; Cell Culture Techniques; Cell Line; Cell Survival; Chemical and Drug Induced Liver Injury; Gene Silencing; Interferon-beta; Lipopolysaccharides; Macrophages, Peritoneal; Male; Mice; Mice, Inbred C57BL; Myeloid Differentiation Factor 88; Nitric Oxide; Nitric Oxide Synthase Type II; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; RNA, Small Interfering; Toluene; Tumor Necrosis Factor-alpha; Tumor Suppressor Protein p53	2013
Inhibition of autophagy via p53-mediated disruption of ULK1 in a SCA7 polyglutamine disease model. Journal of molecular neuroscience : MN, 2013, Volume: 50, Issue:3 Topics: Animals; Ataxin-7; Autophagy; Autophagy-Related Protein-1 Homolog; Benzothiazoles; HEK293 Cells; Humans; Intracellular Signaling Peptides and Proteins; Mutation; Nerve Tissue Proteins; Oligopeptides; PC12 Cells; Peptides; Polymerization; Protein Serine-Threonine Kinases; Rats; Spinocerebellar Ataxias; Toluene; Tumor Suppressor Protein p53	2013
Genes of the mitochondrial apoptotic pathway in Mytilus galloprovincialis. PloS one, 2013, Volume: 8, Issue:4 Topics: Adaptation, Physiological; Amino Acid Sequence; Animals; Apoptosis; Apoptosis Regulatory Proteins; Benzothiazoles; DNA Fragmentation; Ecosystem; Gene Expression Profiling; Gene Expression Regulation; Mitochondria; Mitochondrial Proteins; Molecular Sequence Data; Mytilus; Sequence Alignment; Stress, Physiological; Toluene; Ultraviolet Rays	2013
PI3K/mTOR inhibitor PF-04691502 antitumor activity is enhanced with induction of wild-type TP53 in human xenograft and murine knockout models of head and neck cancer. Clinical cancer research : an official journal of the American Association for Cancer Research, 2013, Jul-15, Volume: 19, Issue:14 Topics: Animals; Antineoplastic Agents; Benzothiazoles; Carcinoma, Squamous Cell; Cell Line, Tumor; Cell Proliferation; Cell Survival; Combined Modality Therapy; Female; Head and Neck Neoplasms; Humans; Mice; Mice, Inbred BALB C; Mice, Knockout; Mice, Nude; Mice, SCID; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Pyridones; Pyrimidines; Signal Transduction; Toluene; TOR Serine-Threonine Kinases; Transcriptional Activation; Tumor Burden; Tumor Suppressor Protein p53; Xenograft Model Antitumor Assays	2013
Overexpression of SIRT1 promotes high glucose-attenuated corneal epithelial wound healing via p53 regulation of the IGFBP3/IGF-1R/AKT pathway. Investigative ophthalmology & visual science, 2013, May-31, Volume: 54, Issue:5 Topics: Animals; Benzothiazoles; Blotting, Western; Cells, Cultured; Down-Regulation; Epithelium, Corneal; Gene Expression Regulation; Glucose; Humans; Insulin-Like Growth Factor Binding Protein 3; Male; Mice; Mice, Inbred C57BL; Microscopy, Confocal; Protein Kinases; Proto-Oncogene Proteins c-akt; Real-Time Polymerase Chain Reaction; Receptor, IGF Type 1; Sirtuin 1; Toluene; Tumor Suppressor Protein p53; Wound Healing	2013
Casticin induces human glioma cell death through apoptosis and mitotic arrest. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 2013, Volume: 31, Issue:6 Topics: Amino Acid Chloromethyl Ketones; Apoptosis; bcl-2-Associated X Protein; Benzothiazoles; Caspase 3; Cell Cycle Checkpoints; Cell Line, Tumor; Flavonoids; G2 Phase Cell Cycle Checkpoints; Glioma; Humans; M Phase Cell Cycle Checkpoints; Toluene; Tubulin; Tumor Suppressor Protein p53; Up-Regulation	2013
Induction of renal fibrotic genes by TGF-β1 requires EGFR activation, p53 and reactive oxygen species. Cellular signalling, 2013, Volume: 25, Issue:11 Topics: Animals; Benzothiazoles; Connective Tissue Growth Factor; Endothelium, Vascular; ErbB Receptors; Fibroblasts; Fibrosis; Gene Expression Regulation; Isoquinolines; Mice; Mink; Myocytes, Smooth Muscle; Pyridines; Pyrroles; Quinazolines; Rats; Reactive Oxygen Species; Renal Insufficiency, Chronic; Serpin E2; Signal Transduction; Smad2 Protein; Smad3 Protein; Toluene; Transforming Growth Factor beta1; Tumor Suppressor Protein p53; Tyrphostins	2013
p53 increases caspase-6 expression and activation in muscle tissue expressing mutant huntingtin. Human molecular genetics, 2014, Feb-01, Volume: 23, Issue:3 Topics: Animals; Benzothiazoles; Caspase 6; Cells, Cultured; Disease Models, Animal; Female; Fibroblasts; Humans; Huntingtin Protein; Huntington Disease; Lamin Type A; Male; Mice; Mice, Transgenic; Muscle, Skeletal; Mutation; Nerve Tissue Proteins; Neurons; Toluene; Tumor Suppressor Protein p53	2014
Regulation of p53 by jagged1 contributes to angiotensin II-induced impairment of myocardial angiogenesis. PloS one, 2013, Volume: 8, Issue:10 Topics: Angiotensin II; Animals; Benzothiazoles; Calcium-Binding Proteins; Cell Nucleus; Collagen; Drug Combinations; Endothelial Cells; Endothelium, Vascular; Gene Expression Regulation; Hypoxia-Inducible Factor 1, alpha Subunit; Infusion Pumps, Implantable; Intercellular Signaling Peptides and Proteins; Jagged-1 Protein; Laminin; Male; Membrane Proteins; Mice; Mice, Inbred C57BL; Myocardium; Neovascularization, Physiologic; Primary Cell Culture; Proteoglycans; Rats; Rats, Wistar; Receptor, Notch1; Serrate-Jagged Proteins; Signal Transduction; Toluene; Tumor Suppressor Protein p53	2013
The anti-cancer activities of Vernonia amygdalina extract in human breast cancer cell lines are mediated through caspase-dependent and p53-independent pathways. PloS one, 2013, Volume: 8, Issue:10 Topics: Antineoplastic Agents; Apoptosis; Benzothiazoles; Breast Neoplasms; Caspases; Cell Cycle; Humans; MCF-7 Cells; Plant Extracts; Toluene; Tumor Suppressor Protein p53; Vernonia	2013
Oridonin induces apoptosis in SW1990 pancreatic cancer cells via p53- and caspase-dependent induction of p38 MAPK. Oncology reports, 2014, Volume: 31, Issue:2 Topics: Anthracenes; Apoptosis; Benzothiazoles; Caspase 3; Caspase 9; Cell Line, Tumor; Cyclin-Dependent Kinase Inhibitor p21; Diterpenes, Kaurane; Enzyme Activation; Extracellular Signal-Regulated MAP Kinases; Flavonoids; G1 Phase Cell Cycle Checkpoints; Humans; Imidazoles; Isodon; JNK Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Pancreatic Neoplasms; Phosphorylation; Plant Preparations; Pyridines; RNA, Messenger; Toluene; Tumor Suppressor Protein p53	2014
Cognitive impairments accompanying rodent mild traumatic brain injury involve p53-dependent neuronal cell death and are ameliorated by the tetrahydrobenzothiazole PFT-α. PloS one, 2013, Volume: 8, Issue:11 Topics: Animals; Benzothiazoles; Brain Injuries; Cell Death; Cell Line; Cell Survival; Cognitive Dysfunction; Dentate Gyrus; Glutamic Acid; Humans; Male; Maze Learning; Mice; Neurons; Oxidative Stress; Primary Cell Culture; Rats; Toluene; Tumor Suppressor Protein p53	2013
The mitochondrial cyclophilin D/p53 complexation mediates doxorubicin-induced non-apoptotic death of A549 lung cancer cells. Molecular and cellular biochemistry, 2014, Volume: 389, Issue:1-2 Topics: Animals; Apoptosis; Benzothiazoles; Cell Death; Cell Line; Cell Line, Tumor; Cyclophilins; Cyclosporine; Doxorubicin; HEK293 Cells; Humans; Lung Neoplasms; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Mitochondria; Peptidyl-Prolyl Isomerase F; Toluene; Tumor Suppressor Protein p53	2014
Inhibition of p53 increases chemosensitivity to 5-FU in nutrient-deprived hepatocarcinoma cells by suppressing autophagy. Cancer letters, 2014, May-01, Volume: 346, Issue:2 Topics: Antimetabolites, Antineoplastic; Apoptosis; Autophagy; Benzothiazoles; Carcinoma, Hepatocellular; Cell Line, Tumor; Drug Synergism; Fluorouracil; Hep G2 Cells; Humans; Liver Neoplasms; Mitochondria, Liver; Reactive Oxygen Species; Toluene; Tumor Suppressor Protein p53	2014
Inhibition of p53 preserves Parkin-mediated mitophagy and pancreatic β-cell function in diabetes. Proceedings of the National Academy of Sciences of the United States of America, 2014, Feb-25, Volume: 111, Issue:8 Topics: Animals; Benzothiazoles; Cell Line; Diabetes Mellitus; Endoplasmic Reticulum Stress; Flow Cytometry; Fluorescent Antibody Technique; Immunoblotting; Immunohistochemistry; Immunoprecipitation; Insulin; Insulin Secretion; Insulin-Secreting Cells; Mice; Mice, Knockout; Microscopy, Electron; Mitophagy; Oxidative Stress; RNA Interference; Toluene; Tumor Suppressor Protein p53; Ubiquitin-Protein Ligases	2014
Quercetin regulates the sestrin 2-AMPK-p38 MAPK signaling pathway and induces apoptosis by increasing the generation of intracellular ROS in a p53-independent manner. International journal of molecular medicine, 2014, Volume: 33, Issue:4 Topics: Acetylcysteine; AMP-Activated Protein Kinases; Apoptosis; bcl-2-Associated X Protein; Benzothiazoles; Cell Line, Tumor; Cell Proliferation; Cell Survival; Enzyme Activation; Humans; Imidazoles; Intracellular Space; MAP Kinase Signaling System; Nuclear Proteins; p38 Mitogen-Activated Protein Kinases; Pyridines; Quercetin; Reactive Oxygen Species; RNA, Small Interfering; Toluene; Transfection; Tumor Suppressor Protein p53	2014
[Effect of PFT-α on apoptosis of spermatogenic cells caused by enorchia]. Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences, 2014, Volume: 39, Issue:3 Topics: Animals; Apoptosis; Benzothiazoles; Cryptorchidism; Disease Models, Animal; Humans; Male; Rats; Rats, Sprague-Dawley; Spermatogonia; Toluene	2014
Silver nanoparticles induce p53-mediated apoptosis in human bronchial epithelial (BEAS-2B) cells. The Journal of toxicological sciences, 2014, Volume: 39, Issue:3 Topics: Apoptosis; bcl-2-Associated X Protein; Benzothiazoles; Bronchi; Caspase 3; Cells, Cultured; DNA Fragmentation; Dose-Response Relationship, Drug; Epithelial Cells; Humans; Lung Diseases; Metal Nanoparticles; Oxidative Stress; Proto-Oncogene Proteins c-bcl-2; RNA, Small Interfering; Silver; Toluene; Tumor Suppressor Protein p53	2014
[Roles of p53 in the interaction of p21 and cell cycle proteins induced by benzo [a] pyrene]. Wei sheng yan jiu = Journal of hygiene research, 2014, Volume: 43, Issue:2 Topics: Benzo(a)pyrene; Benzothiazoles; Cell Cycle; Cell Cycle Proteins; Cyclin D1; Cyclin-Dependent Kinase 4; Cyclin-Dependent Kinase Inhibitor p21; Fibroblasts; Humans; Lung; RNA, Small Interfering; Toluene; Transfection; Tumor Suppressor Protein p53	2014
Cisplatin-induced renal injury is independently mediated by OCT2 and p53. Clinical cancer research : an official journal of the American Association for Cancer Research, 2014, Aug-01, Volume: 20, Issue:15 Topics: Animals; Antineoplastic Agents; Benzothiazoles; Biomarkers; Cisplatin; Female; Gene Expression Profiling; Homeodomain Proteins; Kidney Diseases; Male; Mice; Mice, Knockout; Octamer Transcription Factor-1; Oligonucleotide Array Sequence Analysis; Organic Cation Transport Proteins; Organic Cation Transporter 2; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Toluene; Tumor Suppressor Protein p53	2014
Relationship of p53 accumulation in peripheral tissues of high-fat diet-induced obese rats with decrease in metabolic and oncogenic signaling of insulin. General and comparative endocrinology, 2015, Apr-01, Volume: 214 Topics: Adipose Tissue; Adiposity; Animals; Benzothiazoles; Body Weight; Diet, High-Fat; Fluorescent Antibody Technique; Hypoglycemic Agents; Immunoblotting; Insulin; Insulin Resistance; Male; Obesity; Phosphorylation; Proto-Oncogene Proteins c-akt; PTEN Phosphohydrolase; Rats; Rats, Wistar; Signal Transduction; Toluene; Tumor Suppressor Protein p53	2015
Indoleamine 2,3-dioxygenase increases p53 levels in alloreactive human T cells, and both indoleamine 2,3-dioxygenase and p53 suppress glucose uptake, glycolysis and proliferation. International immunology, 2014, Volume: 26, Issue:12 Topics: Adult; Apoptosis Regulatory Proteins; Benzothiazoles; Carrier Proteins; Cell Proliferation; Cells, Cultured; Enzyme Activation; Female; Glucose; Glucose Transporter Type 1; Glucosephosphate Dehydrogenase; Glycolysis; Healthy Volunteers; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Intracellular Signaling Peptides and Proteins; Isoenzymes; L-Lactate Dehydrogenase; Lactate Dehydrogenase 5; Lactic Acid; Leukocytes, Mononuclear; Lymphocyte Activation; Lymphocyte Culture Test, Mixed; Male; Mechanistic Target of Rapamycin Complex 1; Middle Aged; Mitochondrial Proteins; Molecular Chaperones; Multiprotein Complexes; Phosphoric Monoester Hydrolases; T-Lymphocytes; Toluene; TOR Serine-Threonine Kinases; Tryptophan; Tumor Suppressor Protein p53	2014
Modulation of the poly (ADP-ribose) polymerase inhibitor response and DNA recombination in breast cancer cells by drugs affecting endogenous wild-type p53. Carcinogenesis, 2014, Volume: 35, Issue:10 Topics: Benzothiazoles; Breast Neoplasms; Cell Line, Tumor; Enzyme Inhibitors; Female; Gene Knockdown Techniques; Genes, p53; Humans; Imidazoles; Isoquinolines; Molecular Weight; Piperazines; Poly(ADP-ribose) Polymerase Inhibitors; Poly(ADP-ribose) Polymerases; Recombinational DNA Repair; RNA, Small Interfering; Toluene	2014
Actin cytoskeleton organization, cell surface modification and invasion rate of 5 glioblastoma cell lines differing in PTEN and p53 status. Experimental cell research, 2015, Jan-15, Volume: 330, Issue:2 Topics: Actin Cytoskeleton; Actins; Benzothiazoles; Brain Neoplasms; Cell Adhesion; Cell Line, Tumor; Cell Movement; Glioblastoma; Humans; MAP Kinase Signaling System; Neoplasm Invasiveness; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; PTEN Phosphohydrolase; RNA Interference; RNA, Small Interfering; Toluene; TOR Serine-Threonine Kinases; Tumor Suppressor Protein p53	2015
p53 Suppression partially rescues the mutant phenotype in mouse models of DiGeorge syndrome. Proceedings of the National Academy of Sciences of the United States of America, 2014, Sep-16, Volume: 111, Issue:37 Topics: Animals; Arteries; Benzothiazoles; Branchial Region; Chromatin; Crosses, Genetic; DiGeorge Syndrome; Disease Models, Animal; Down-Regulation; Embryo, Mammalian; Epistasis, Genetic; Female; Gene Deletion; Gene Expression Regulation, Developmental; Homeodomain Proteins; Male; Mice; Mice, Mutant Strains; Mutation; Phenotype; Protein Binding; T-Box Domain Proteins; Toluene; Tumor Suppressor Protein p53	2014
Microglial p53 activation is detrimental to neuronal synapses during activation-induced inflammation: Implications for neurodegeneration. Neuroscience letters, 2014, Nov-07, Volume: 583 Topics: Animals; Apoptosis; Benzothiazoles; Brain; Cells, Cultured; Inflammation; Lipopolysaccharides; Microglia; Neurons; Rats, Sprague-Dawley; Sulfonamides; Synapses; Toluene; Transcription, Genetic; Tumor Suppressor Protein p53	2014
Intrauterine ischemic reperfusion switches the fetal transcriptional pattern from HIF-1α- to P53-dependent regulation in the murine brain. PloS one, 2014, Volume: 9, Issue:10 Topics: Animals; Benzothiazoles; Brain Injuries; Female; Fetus; Gene Expression Regulation; Hypoxia-Inducible Factor 1, alpha Subunit; Mice; Pregnancy; Reperfusion; Signal Transduction; Toluene; TOR Serine-Threonine Kinases; Tumor Suppressor Protein p53; Uterus	2014
Pifithrin-α provides neuroprotective effects at the level of mitochondria independently of p53 inhibition. Apoptosis : an international journal on programmed cell death, 2014, Volume: 19, Issue:12 Topics: Apoptosis; Apoptosis Regulatory Proteins; Benzothiazoles; Cell Line, Tumor; Cell Membrane; Gene Knockout Techniques; Glutamic Acid; Hippocampus; Humans; Lipid Peroxidation; Mitochondria; Neurons; Neuroprotective Agents; Oxidative Stress; RNA, Small Interfering; Toluene; Tumor Suppressor Protein p53	2014
Granzyme B-activated p53 interacts with Bcl-2 to promote cytotoxic lymphocyte-mediated apoptosis. Journal of immunology (Baltimore, Md. : 1950), 2015, Jan-01, Volume: 194, Issue:1 Topics: Apoptosis; bcl-2-Associated X Protein; Benzothiazoles; BH3 Interacting Domain Death Agonist Protein; Caspase 3; Cell Line, Tumor; Cytochromes c; Enzyme Activation; Granzymes; Humans; Killer Cells, Natural; MCF-7 Cells; Mitochondria; Mitochondrial Membranes; RNA Interference; RNA, Small Interfering; T-Lymphocytes, Cytotoxic; Toluene; Tumor Suppressor Protein p53	2015
[The role of p53 in the regulation of proliferation and differentiation of the neural progenitors in mouse hippocampal organotypic culture]. Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova, 2013, Volume: 99, Issue:10 Topics: Acetanilides; Animals; Antineoplastic Agents; Benzothiazoles; Cell Proliferation; Cells, Cultured; Hippocampus; Intercellular Signaling Peptides and Proteins; Mice; Nerve Tissue Proteins; Neural Stem Cells; Neurogenesis; Prohibitins; Proto-Oncogene Proteins c-pim-1; Repressor Proteins; Thiourea; Toluene; Tumor Suppressor Protein p53	2013
Pivotal roles of p53 transcription-dependent and -independent pathways in manganese-induced mitochondrial dysfunction and neuronal apoptosis. Toxicology and applied pharmacology, 2014, Dec-15, Volume: 281, Issue:3 Topics: Animals; Antidotes; Apoptosis; Benzothiazoles; Cell Nucleus; Corpus Striatum; Cytoplasm; Male; Manganese; Manganese Poisoning; Membrane Potential, Mitochondrial; Mitochondria; Nerve Tissue Proteins; Neurons; PC12 Cells; Protein Transport; Random Allocation; Rats; Rats, Sprague-Dawley; Sulfonamides; Toluene; Tumor Suppressor Protein p53; Up-Regulation	2014
Pifithrin-alpha has a p53-independent cytoprotective effect on docosahexaenoic acid-induced cytotoxicity in human hepatocellular carcinoma HepG2 cells. Toxicology letters, 2015, Jan-22, Volume: 232, Issue:2 Topics: Antioxidants; Autophagy; Benzothiazoles; Cell Line, Tumor; Cell Survival; Docosahexaenoic Acids; Gene Knockdown Techniques; Genes, p53; Humans; Membrane Potential, Mitochondrial; Oxidative Stress; RNA, Small Interfering; Toluene	2015
Effect of p53 inhibition by pifithrin-alpha on functional activity of vasopressin neurones in rat hypothalamus. Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova, 2013, Volume: 99, Issue:8 Topics: Animals; Benzothiazoles; Hypothalamo-Hypophyseal System; Hypothalamus; Male; MAP Kinase Signaling System; Neurons; Rats; Supraoptic Nucleus; Toluene; Tumor Suppressor Protein p53; Vasopressins	2013
Mimulone-induced autophagy through p53-mediated AMPK/mTOR pathway increases caspase-mediated apoptotic cell death in A549 human lung cancer cells. PloS one, 2014, Volume: 9, Issue:12 Topics: Adenocarcinoma; Adenocarcinoma of Lung; AMP-Activated Protein Kinases; Antineoplastic Agents, Phytogenic; Apoptosis; Autophagy; Benzothiazoles; Cell Line, Tumor; Cell Survival; Flavanones; Gene Knockdown Techniques; HCT116 Cells; Humans; Lamiales; Lung Neoplasms; MCF-7 Cells; Toluene; TOR Serine-Threonine Kinases; Tumor Suppressor Protein p53	2014
Pifithrin-α ameliorates resveratrol-induced two-cell block in mouse preimplantation embryos in vitro. Theriogenology, 2015, Mar-15, Volume: 83, Issue:5 Topics: Animals; Benzothiazoles; Blastocyst; Cytoprotection; Embryo, Mammalian; Enzyme Inhibitors; Gene Expression Regulation, Developmental; Mice; Resveratrol; Stilbenes; Toluene; Tumor Suppressor Protein p53	2015
Calpain-3 impairs cell proliferation and stimulates oxidative stress-mediated cell death in melanoma cells. PloS one, 2015, Volume: 10, Issue:2 Topics: Benzothiazoles; Calpain; Cell Death; Cell Line, Tumor; Cell Proliferation; Humans; Melanoma; Muscle Proteins; Mutation; Oxidation-Reduction; Oxidative Stress; Reactive Oxygen Species; Toluene; Tumor Suppressor Protein p53; Up-Regulation	2015
p53 inhibition provides a pivotal protective effect against ischemia-reperfusion injury in vitro via mTOR signaling. Brain research, 2015, Apr-24, Volume: 1605 Topics: Animals; Benzothiazoles; Cells, Cultured; Female; Mice; Mice, Inbred C57BL; Neurons; Neuroprotective Agents; Pregnancy; Reperfusion Injury; Signal Transduction; Sirolimus; Toluene; TOR Serine-Threonine Kinases; Tumor Suppressor Protein p53	2015
The Anti-Inflammatory Effects of the Small Molecule Pifithrin-µ on BV2 Microglia. Developmental neuroscience, 2015, Volume: 37, Issue:4-5 Topics: Animals; Benzothiazoles; Cell Line; Gene Expression; Inflammation; Mice; Microglia; Mitochondria; Neuroprotective Agents; Toluene; Tumor Suppressor Protein p53	2015
Augmented BMP signaling in the neural crest inhibits nasal cartilage morphogenesis by inducing p53-mediated apoptosis. Development (Cambridge, England), 2015, Apr-01, Volume: 142, Issue:7 Topics: Animals; Animals, Newborn; Apoptosis; Benzothiazoles; Bone Morphogenetic Protein Receptors, Type I; Bone Morphogenetic Proteins; Cell Nucleus; Cell Survival; Chondrogenesis; Embryo Loss; Embryo, Mammalian; Fibroblast Growth Factors; Integrases; Mesoderm; Mice; Morphogenesis; Mutation; Nasal Cartilages; Nasal Mucosa; Neural Crest; Nose; Protein Binding; Proteolysis; Proto-Oncogene Proteins c-mdm2; Signal Transduction; Smad Proteins; Toluene; Tumor Suppressor Protein p53	2015
Scopadulciol, Isolated from Scoparia dulcis, Induces β-Catenin Degradation and Overcomes Tumor Necrosis Factor-Related Apoptosis Ligand Resistance in AGS Human Gastric Adenocarcinoma Cells. Journal of natural products, 2015, Apr-24, Volume: 78, Issue:4 Topics: Abietanes; Adenocarcinoma; Apoptosis; Benzothiazoles; beta Catenin; Down-Regulation; Humans; Leupeptins; Molecular Structure; Receptors, TNF-Related Apoptosis-Inducing Ligand; Scoparia; Stomach Neoplasms; TNF-Related Apoptosis-Inducing Ligand; Toluene; Tumor Necrosis Factor-alpha	2015
Post-trauma administration of the pifithrin-α oxygen analog improves histological and functional outcomes after experimental traumatic brain injury. Experimental neurology, 2015, Volume: 269 Topics: Animals; Apoptosis; Benzothiazoles; Brain Injuries; Cell Survival; Disease Models, Animal; Male; Neurons; Neuroprotective Agents; Oxygen; Rats, Sprague-Dawley; Recovery of Function; Toluene; Treatment Outcome; Tumor Suppressor Protein p53	2015
NSC666715 and Its Analogs Inhibit Strand-Displacement Activity of DNA Polymerase β and Potentiate Temozolomide-Induced DNA Damage, Senescence and Apoptosis in Colorectal Cancer Cells. PloS one, 2015, Volume: 10, Issue:5 Topics: Apoptosis; Benzothiazoles; Cell Cycle; Cell Cycle Checkpoints; Cellular Senescence; Colorectal Neoplasms; Cyclin-Dependent Kinase Inhibitor p21; Dacarbazine; DNA Damage; DNA Polymerase beta; DNA Repair; Enzyme Inhibitors; HCT116 Cells; Humans; Small Molecule Libraries; Sulfhydryl Compounds; Sulfonamides; Temozolomide; Toluene; Triazoles; Tumor Suppressor Protein p53	2015
Role of JNK and Contribution of p53 into Growth Potential of Mesenchymal Progenitor Cells In Vitro. Bulletin of experimental biology and medicine, 2015, Volume: 159, Issue:2 Topics: Animals; Benzothiazoles; Cell Proliferation; Hydroxyurea; In Vitro Techniques; Male; MAP Kinase Kinase 4; Mesenchymal Stem Cells; Mice; Mice, Inbred CBA; Protein Kinase Inhibitors; Signal Transduction; Statistics, Nonparametric; Toluene; Tumor Suppressor Protein p53	2015
Inactivation of p53 Is Sufficient to Induce Development of Pulmonary Hypertension in Rats. PloS one, 2015, Volume: 10, Issue:6 Topics: Animals; Apoptosis; Benzothiazoles; Cell Proliferation; Humans; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Male; Monocrotaline; Rats; Rats, Wistar; Toluene; Tumor Suppressor Protein p53	2015
FFA-ROS-P53-mediated mitochondrial apoptosis contributes to reduction of osteoblastogenesis and bone mass in type 2 diabetes mellitus. Scientific reports, 2015, Jul-31, Volume: 5 Topics: Adult; Animals; Apoptosis; Benzothiazoles; Bone Density; Cross-Sectional Studies; Diabetes Mellitus, Type 2; DNA, Mitochondrial; Epoxy Compounds; Fatty Acids, Nonesterified; Humans; Lipid Peroxidation; Male; Mice, Inbred C57BL; Middle Aged; Mitochondria; Organophosphorus Compounds; Osteoblasts; Osteogenesis; Reactive Oxygen Species; Toluene; Tumor Suppressor Protein p53; Ubiquinone	2015
Ablation of XP-V gene causes adipose tissue senescence and metabolic abnormalities. Proceedings of the National Academy of Sciences of the United States of America, 2015, Aug-18, Volume: 112, Issue:33 Topics: 3T3-L1 Cells; Adipocytes; Adipose Tissue; Animals; Benzothiazoles; Blood Glucose; Cellular Senescence; Comet Assay; DNA Damage; DNA-Directed DNA Polymerase; Gene Expression Regulation, Neoplastic; Genotype; Immunohistochemistry; Insulin Resistance; Macrophages; Male; Metabolic Syndrome; Mice; Mice, Knockout; Neoplasm Transplantation; Reactive Oxygen Species; Toluene	2015
The p53 inhibitor, pifithrin-α, disrupts microtubule organization, arrests growth, and induces polyploidy in the rainbow trout gill cell line, RTgill-W1. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP, 2016, Volume: 179 Topics: Animals; Benzothiazoles; Cell Line; Cell Survival; Dose-Response Relationship, Drug; Epithelial Cells; Genes, p53; Gills; Growth Inhibitors; Microtubules; Oncorhynchus mykiss; Polyploidy; Toluene	2016
Inhibition of p53 attenuates ischemic stress-induced activation of astrocytes. Neuroreport, 2015, Sep-30, Volume: 26, Issue:14 Topics: Animals; Astrocytes; Benzothiazoles; Brain Ischemia; Cell Hypoxia; Cells, Cultured; Central Nervous System Agents; Glucose; Glutamic Acid; Infarction, Middle Cerebral Artery; Male; Neurons; Rats, Sprague-Dawley; RNA Interference; Stress, Physiological; Toluene; Tumor Suppressor Protein p53	2015
Role of Autophagy in Capsaicin-Induced Apoptosis in U251 Glioma Cells. Cellular and molecular neurobiology, 2016, Volume: 36, Issue:5 Topics: Apoptosis; Autophagy; Benzothiazoles; Capsaicin; Caspase 3; Cell Line, Tumor; Cell Survival; Glioma; Humans; Signal Transduction; Toluene	2016
Role of JNK and Involvement of p53 in Stimulation of Growth Potential Realization of Mesenchymal Precursor Cells by Alkaloid Songorine. Bulletin of experimental biology and medicine, 2015, Volume: 160, Issue:1 Topics: Alkaloids; Animals; Apoptosis; Benzothiazoles; Cells, Cultured; Colony-Forming Units Assay; JNK Mitogen-Activated Protein Kinases; Male; MAP Kinase Signaling System; Mesenchymal Stem Cells; Mice; Mice, Inbred CBA; Protein Kinase Inhibitors; Toluene; Tumor Suppressor Protein p53	2015
Metformin Restores Parkin-Mediated Mitophagy, Suppressed by Cytosolic p53. International journal of molecular sciences, 2016, Jan-16, Volume: 17, Issue:1 Topics: Animals; Benzothiazoles; Caloric Restriction; Cell Survival; Diet; Endoplasmic Reticulum Stress; Fatty Liver; Gene Expression Regulation; Glucose; Hep G2 Cells; Humans; Hypoglycemic Agents; Metformin; Mice; Mice, Obese; Mitochondria; Mitophagy; Palmitic Acid; Signal Transduction; Sirtuin 1; Toluene; Tumor Suppressor Protein p53; Ubiquitin-Protein Ligases	2016
GSIV serine/threonine kinase can induce apoptotic cell death via p53 and pro-apoptotic gene Bax upregulation in fish cells. Apoptosis : an international journal on programmed cell death, 2016, Volume: 21, Issue:4 Topics: Animals; Apoptosis; Bass; bcl-2-Associated X Protein; Benzothiazoles; Caspase 3; Caspase 9; Cell Line; Enzyme Activation; In Situ Nick-End Labeling; Iridovirus; Membrane Potential, Mitochondrial; Mitochondria; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins c-bcl-2; Toluene; Tumor Suppressor Protein p53	2016
Preclinical effects of honokiol on treating glioblastoma multiforme via G1 phase arrest and cell apoptosis. Phytomedicine : international journal of phytotherapy and phytopharmacology, 2016, May-15, Volume: 23, Issue:5 Topics: Animals; Apoptosis; Benzothiazoles; Biphenyl Compounds; Caspases; Cell Cycle Checkpoints; Cell Cycle Proteins; Cell Line, Tumor; Down-Regulation; Drug Evaluation, Preclinical; Female; G1 Phase; Glioblastoma; Humans; Lignans; Mice; Mice, Inbred BALB C; Mice, Nude; Toluene; Tumor Suppressor Protein p53	2016
Activation of PPARγ/P53 signaling is required for curcumin to induce hepatic stellate cell senescence. Cell death & disease, 2016, Apr-14, Volume: 7 Topics: Animals; Benzothiazoles; Cell Cycle Checkpoints; Cell Proliferation; Cellular Senescence; Curcumin; Cyclin-Dependent Kinase Inhibitor p16; Cyclin-Dependent Kinase Inhibitor p21; Enzyme Inhibitors; Hepatic Stellate Cells; HMGA1a Protein; Liver; Liver Cirrhosis; Male; Mice; Mice, Inbred ICR; PPAR gamma; Rats; Rats, Sprague-Dawley; RNA Interference; Signal Transduction; Toluene; Tumor Suppressor Protein p53	2016
Gambogic Acid Inhibits Malignant Melanoma Cell Proliferation Through Mitochondrial p66shc/ROS-p53/Bax-Mediated Apoptosis. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 2016, Volume: 38, Issue:4 Topics: Acetylcysteine; Animals; Antineoplastic Agents; Apoptosis; bcl-2-Associated X Protein; Benzothiazoles; Cell Line, Tumor; Cell Proliferation; Humans; Male; Melanoma; Membrane Potential, Mitochondrial; Mice; Mice, Nude; Mitochondria; Reactive Oxygen Species; RNA, Small Interfering; Src Homology 2 Domain-Containing, Transforming Protein 1; Toluene; Transplantation, Heterologous; Tumor Suppressor Protein p53; Xanthones	2016
Optimized Approaches for Generation of Integration-free iPSCs from Human Urine-Derived Cells with Small Molecules and Autologous Feeder. Stem cell reports, 2016, 05-10, Volume: 6, Issue:5 Topics: Benzamides; Benzothiazoles; Cell Differentiation; Cell Proliferation; Cellular Reprogramming; Diphenylamine; Humans; Induced Pluripotent Stem Cells; Pyrazoles; Pyridines; Pyrimidines; Thiazoles; Thiosemicarbazones; Toluene; Urine	2016
Anesthetic Isoflurane Induces DNA Damage Through Oxidative Stress and p53 Pathway. Molecular neurobiology, 2017, Volume: 54, Issue:5 Topics: Acetylcysteine; Anesthetics, Inhalation; Animals; Benzothiazoles; Brain; Caspase 3; Cell Line, Tumor; Cytosol; Dactinomycin; Deoxyribonucleases; DNA Damage; Enzyme Activation; Histones; Humans; Isoflurane; Mice; Models, Biological; Oligopeptides; Oxidative Stress; Signal Transduction; Toluene; Tumor Suppressor Protein p53	2017
Regenerative repair of Pifithrin-α in cerebral ischemia via VEGF dependent manner. Scientific reports, 2016, 05-23, Volume: 6 Topics: Animals; Benzothiazoles; Brain Ischemia; Cell Proliferation; Disease Models, Animal; In Vitro Techniques; Male; Neovascularization, Physiologic; Neural Stem Cells; Neurogenesis; Neuroprotective Agents; Rats; Rats, Sprague-Dawley; Regeneration; Signal Transduction; Stroke; Toluene; Tumor Suppressor Protein p53; Vascular Endothelial Growth Factor A	2016
Cardiac arrest triggers hippocampal neuronal death through autophagic and apoptotic pathways. Scientific reports, 2016, 06-08, Volume: 6 Topics: Animals; Apoptosis; Autophagy; Benzothiazoles; Biomarkers; Blood Gas Analysis; Cell Death; Disease Models, Animal; Gene Expression; Heart Arrest; Hippocampus; Male; Microtubule-Associated Proteins; Pyramidal Cells; Rats; Toluene; Tumor Suppressor Protein p53	2016
p53 Mediates Colistin-Induced Autophagy and Apoptosis in PC-12 Cells. Antimicrobial agents and chemotherapy, 2016, Volume: 60, Issue:9 Topics: AMP-Activated Protein Kinases; Animals; Anti-Bacterial Agents; Apoptosis; Apoptosis Regulatory Proteins; Autophagy; bcl-2-Associated X Protein; Benzothiazoles; Caspase 3; Cell Differentiation; Colistin; Gene Expression Regulation; Membrane Proteins; Microtubule-Associated Proteins; Neurons; PC12 Cells; Rats; Signal Transduction; Toluene; TOR Serine-Threonine Kinases; Tumor Suppressor Protein p53	2016
Post-traumatic administration of the p53 inactivator pifithrin-α oxygen analogue reduces hippocampal neuronal loss and improves cognitive deficits after experimental traumatic brain injury. Neurobiology of disease, 2016, Volume: 96 Topics: Aldehydes; Animals; Annexin A5; Apoptosis Regulatory Proteins; Benzothiazoles; Brain; Brain Injuries, Traumatic; Cognition Disorders; Disease Models, Animal; Electron Transport Complex IV; Exploratory Behavior; Fluoresceins; Magnetic Resonance Imaging; Male; Oxygen; Rats; Rats, Sprague-Dawley; Recognition, Psychology; RNA, Messenger; Time Factors; Toluene; Tumor Suppressor Protein p53	2016
The antioxidant transcription factor Nrf2 contributes to the protective effect of mild thermotolerance (40°C) against heat shock-induced apoptosis. Free radical biology & medicine, 2016, Volume: 99 Topics: Apoptosis; Benzothiazoles; Catalase; Gene Expression Regulation; Glutamate-Cysteine Ligase; HeLa Cells; Heme Oxygenase-1; Hot Temperature; HSP70 Heat-Shock Proteins; Humans; NF-E2-Related Factor 2; Polyethylene Glycols; Pyrazines; RNA, Small Interfering; Signal Transduction; Stress, Physiological; Superoxide Dismutase; Thermotolerance; Thiones; Thiophenes; Toluene; Tumor Suppressor Protein p53	2016
Induction of microRNA-17-5p by p53 protects against renal ischemia-reperfusion injury by targeting death receptor 6. Kidney international, 2017, Volume: 91, Issue:1 Topics: Acute Kidney Injury; Animals; Apoptosis; Benzothiazoles; Caspases; Cell Line; Disease Models, Animal; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Kidney Tubules; Mice; Mice, Inbred C57BL; Mice, Knockout; MicroRNAs; Mutation; Receptors, Tumor Necrosis Factor; Reperfusion Injury; Signal Transduction; Toluene; Tumor Suppressor Protein p53; Up-Regulation	2017
MG132 plus apoptosis antigen-1 (APO-1) antibody cooperate to restore p53 activity inducing autophagy and p53-dependent apoptosis in HPV16 E6-expressing keratinocytes. Apoptosis : an international journal on programmed cell death, 2017, Volume: 22, Issue:1 Topics: Antibodies; Apoptosis; Autophagy; bcl-2-Associated X Protein; Benzothiazoles; Carrier Proteins; Cyclin-Dependent Kinase Inhibitor p21; fas Receptor; Female; Heat-Shock Proteins; Humans; Keratinocytes; Leupeptins; Oncogene Proteins, Viral; Proteasome Endopeptidase Complex; Proteolysis; Repressor Proteins; Toluene; Tumor Suppressor Protein p53; Uterine Cervical Neoplasms	2017
p53 activates miR-192-5p to mediate vancomycin induced AKI. Scientific reports, 2016, 12-12, Volume: 6 Topics: Acute Kidney Injury; Animals; Apoptosis; Benzothiazoles; Blood Urea Nitrogen; Cell Cycle; Cell Line; Epithelial Cells; Genes, p53; Kidney Tubules; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; MicroRNAs; Toluene; Tumor Suppressor Protein p53; Vancomycin	2016
5-Fluorouracil inhibits cell migration by induction of Sestrin2 in colon cancer cells. Archives of pharmacal research, 2017, Volume: 40, Issue:2 Topics: Antimetabolites, Antineoplastic; Antioxidants; Benzothiazoles; Cell Movement; Colorectal Neoplasms; Fluorouracil; Gene Knockdown Techniques; HCT116 Cells; Heat-Shock Proteins; HT29 Cells; Humans; NF-E2-Related Factor 2; Nuclear Proteins; Phosphorylation; Reactive Oxygen Species; RNA Interference; RNA, Small Interfering; Signal Transduction; Toluene; Transcriptional Activation; Tumor Suppressor Protein p53; Up-Regulation	2017
Effect of potential role of p53 on embryo development arrest induced by H In vitro cellular & developmental biology. Animal, 2017, Volume: 53, Issue:4 Topics: Acetylcysteine; Animals; Benzothiazoles; Cell Cycle; Cell Cycle Checkpoints; Embryo, Mammalian; Embryonic Development; Female; Hydrogen Peroxide; Intracellular Space; Male; Mice; Oxidative Stress; Phosphorylation; Serine; Toluene; Tumor Suppressor Protein p53; Zygote	2017
Induction of Bex genes by curcumin is associated with apoptosis and activation of p53 in N2a neuroblastoma cells. Scientific reports, 2017, 02-01, Volume: 7 Topics: Androstadienes; Animals; Anthracenes; Apoptosis; Benzothiazoles; Cell Line, Tumor; Curcumin; Enzyme Activation; Extracellular Signal-Regulated MAP Kinases; Gene Expression Regulation, Neoplastic; JNK Mitogen-Activated Protein Kinases; Mice; Models, Biological; Nerve Tissue Proteins; Neuroblastoma; Phosphatidylinositol 3-Kinases; Phosphorylation; Promoter Regions, Genetic; Signal Transduction; Time Factors; Toluene; Tumor Suppressor Protein p53; Wortmannin	2017
Protective role of p53 in acetaminophen hepatotoxicity. Free radical biology & medicine, 2017, Volume: 106 Topics: Acetaminophen; Animals; Benzothiazoles; Chemical and Drug Induced Liver Injury; Gene Knockdown Techniques; Gene Knockout Techniques; Hepatocytes; Humans; Imidazoles; Liver; MAP Kinase Kinase 4; Mice; Oligonucleotides, Antisense; Piperazines; Signal Transduction; Toluene; Tumor Suppressor Protein p53	2017
Diosmetin Induces Cell Apoptosis by Regulating CYP1A1/CYP1A2 Due to p53 Activation in HepG2 Cells. Protein and peptide letters, 2017, May-10, Volume: 24, Issue:5 Topics: Apoptosis; Benzothiazoles; Cell Proliferation; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP1A2; Flavonoids; Hep G2 Cells; Humans; Signal Transduction; Toluene; Tumor Suppressor Protein p53	2017
PTEN Reduced UVB-Mediated Apoptosis in Retinal Pigment Epithelium Cells. BioMed research international, 2017, Volume: 2017 Topics: Apoptosis; Benzothiazoles; Cell Line; Cell Survival; Down-Regulation; Gene Expression Regulation, Enzymologic; Humans; Macular Degeneration; Oxidative Stress; PTEN Phosphohydrolase; Retinal Pigment Epithelium; Toluene; Tumor Suppressor Protein p53; Ultraviolet Rays	2017
Dopaminergic Neuron-Specific Deletion of p53 Gene Attenuates Methamphetamine Neurotoxicity. Neurotoxicity research, 2017, Volume: 32, Issue:2 Topics: Animals; bcl-2-Associated X Protein; Benzothiazoles; Central Nervous System Stimulants; Disease Models, Animal; Dopamine Plasma Membrane Transport Proteins; Enzyme Inhibitors; Exploratory Behavior; Fever; Glial Fibrillary Acidic Protein; Male; Methamphetamine; Mice; Mice, Inbred C57BL; Mice, Transgenic; Mutation; Neurotoxicity Syndromes; rho GTP-Binding Proteins; Substantia Nigra; Toluene; Tumor Suppressor Protein p53; Tyrosine 3-Monooxygenase; Up-Regulation	2017
Bre Enhances Osteoblastic Differentiation by Promoting the Mdm2-Mediated Degradation of p53. Stem cells (Dayton, Ohio), 2017, Volume: 35, Issue:7 Topics: Animals; Benzothiazoles; Bone and Bones; Bone Marrow Cells; Cell Differentiation; Cyclin-Dependent Kinase Inhibitor p21; Disease Models, Animal; Female; Gene Expression Regulation; Mesenchymal Stem Cells; Mice; Mice, Inbred BALB C; Mice, Nude; Nerve Tissue Proteins; Nuclear Proteins; Osteogenesis; Osteoporosis; Primary Cell Culture; Protein Stability; Proto-Oncogene Proteins c-mdm2; RNA, Small Interfering; Signal Transduction; Tissue Engineering; Tissue Scaffolds; Toluene; Tumor Suppressor Protein p53	2017
MgAl layered double hydroxide/chitosan porous scaffolds loaded with PFTα to promote bone regeneration. Nanoscale, 2017, May-25, Volume: 9, Issue:20 Topics: Aluminum Compounds; Animals; Benzothiazoles; Bone Regeneration; Cell Differentiation; Cells, Cultured; Chitosan; Humans; Hydroxides; Magnesium Compounds; Male; Mesenchymal Stem Cells; Osteogenesis; Rats; Rats, Sprague-Dawley; Stem Cells; Tissue Engineering; Tissue Scaffolds; Toluene	2017
Intermittent low dose irradiation enhances the effectiveness of radio- and chemo-therapy for human colorectal adenocarcinoma cell line HT-29. Oncology reports, 2017, Volume: 38, Issue:1 Topics: Adenocarcinoma; Antimetabolites, Antineoplastic; Ataxia Telangiectasia Mutated Proteins; Benzothiazoles; Cell Proliferation; Chemoradiotherapy; Colorectal Neoplasms; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Fluorouracil; HT29 Cells; Humans; Imidazoles; MAP Kinase Signaling System; Morpholines; p38 Mitogen-Activated Protein Kinases; Pyridines; Pyrones; Radiation Dosage; Toluene; Tumor Suppressor Protein p53	2017
Neuroprotection with the P53-Inhibitor Pifithrin-μ after Cardiac Arrest in a Rodent Model. Shock (Augusta, Ga.), 2018, Volume: 49, Issue:2 Topics: Animals; Apoptosis; Benzothiazoles; Heart Arrest; Male; Neuroprotection; Random Allocation; Rats; Rats, Wistar; Toluene; Tumor Suppressor Protein p53	2018
The induction of tumour suppressor protein P53 limits the entry of cells into the pluripotent inner cell mass lineage in the mouse embryo. Experimental cell research, 2017, 09-15, Volume: 358, Issue:2 Topics: Animals; Apoptosis; Benzothiazoles; Blastocyst; Cell Lineage; Embryonic Development; Gene Expression Regulation, Developmental; Genes, Homeobox; Imidazoles; Mice, Transgenic; Piperazines; Proto-Oncogene Proteins c-mdm2; Signal Transduction; Toluene; Tumor Suppressor Protein p53	2017
p53-Dependent PUMA to DRAM antagonistic interplay as a key molecular switch in cell-fate decision in normal/high glucose conditions. Journal of experimental & clinical cancer research : CR, 2017, 09-11, Volume: 36, Issue:1 Topics: Animals; Apoptosis; Apoptosis Regulatory Proteins; Autophagy; Autophagy-Related Protein 5; Benzothiazoles; Cell Line, Tumor; Doxorubicin; Gene Expression Regulation, Neoplastic; Glucose; Humans; Membrane Proteins; Mice; Neoplasms; Proto-Oncogene Proteins; RNA, Small Interfering; Toluene; Tumor Suppressor Protein p53	2017
Omega-3 Polyunsaturated Fatty Acids Eicosapentaenoic Acid and Docosahexaenoic Acid Enhance Dexamethasone Sensitivity in Multiple Myeloma Cells by the p53/miR-34a/Bcl-2 Axis. Biochemistry. Biokhimiia, 2017, Volume: 82, Issue:7 Topics: 3' Untranslated Regions; Antagomirs; Antineoplastic Agents; Apoptosis; Benzothiazoles; Cell Line, Tumor; Dexamethasone; Docosahexaenoic Acids; Eicosapentaenoic Acid; Gene Expression; Humans; MicroRNAs; Multiple Myeloma; Proto-Oncogene Proteins c-bcl-2; Signal Transduction; Toluene; Tumor Suppressor Protein p53	2017
IFI16 restoration in hepatocellular carcinoma induces tumour inhibition via activation of p53 signals and inflammasome. Cell proliferation, 2017, Volume: 50, Issue:6 Topics: Benzothiazoles; Carcinoma, Hepatocellular; Cell Line; Humans; Inflammasomes; Liver Neoplasms; Nuclear Proteins; Phosphoproteins; Toluene; Transcriptional Activation; Tumor Suppressor Protein p53	2017
RECK inhibits cervical cancer cell migration and invasion by promoting p53 signaling pathway. Journal of cellular biochemistry, 2018, Volume: 119, Issue:4 Topics: Benzothiazoles; Cell Line, Tumor; Cell Movement; Down-Regulation; Female; Gene Expression Regulation, Neoplastic; GPI-Linked Proteins; HeLa Cells; Humans; Neoplasm Invasiveness; Signal Transduction; Toluene; Tumor Suppressor Protein p53; Uterine Cervical Neoplasms	2018
MicroRNA-188-3p is involved in sevoflurane anesthesia-induced neuroapoptosis by targeting MDM2. Molecular medicine reports, 2018, Volume: 17, Issue:3 Topics: Anesthetics, Inhalation; Animals; Antagomirs; Apoptosis; Benzothiazoles; Cell Line, Tumor; Cognitive Dysfunction; Gene Expression Regulation; Genes, Reporter; Hippocampus; Humans; Luciferases; Male; Maze Learning; Methyl Ethers; MicroRNAs; Molecular Mimicry; Neurons; Oligoribonucleotides; Proto-Oncogene Proteins c-mdm2; Rats; Rats, Sprague-Dawley; Sevoflurane; Signal Transduction; Toluene; Tumor Suppressor Protein p53	2018
Inhibition of p53 prevents diabetic cardiomyopathy by preventing early-stage apoptosis and cell senescence, reduced glycolysis, and impaired angiogenesis. Cell death & disease, 2018, 01-23, Volume: 9, Issue:2 Topics: Animals; Apoptosis; Benzothiazoles; Cardiotonic Agents; Cellular Senescence; Diabetic Cardiomyopathies; Glucose; Glycolysis; Heart; Hypoxia-Inducible Factor 1, alpha Subunit; Inflammation; Male; Mice; Mitochondria; Neovascularization, Physiologic; Oxidative Stress; Proteasome Endopeptidase Complex; Proteolysis; Proto-Oncogene Proteins c-mdm2; Toluene; Tumor Suppressor Protein p53; Ubiquitination	2018
Cell death mechanisms of the anti-cancer drug etoposide on human cardiomyocytes isolated from pluripotent stem cells. Archives of toxicology, 2018, Volume: 92, Issue:4 Topics: Anthracyclines; Antineoplastic Agents; Apoptosis; Benzothiazoles; Calcium Channels; Calcium-Binding Proteins; Cell Death; Cells, Cultured; Cytoskeletal Proteins; Down-Regulation; Etoposide; Gene Expression; Humans; MicroRNAs; Mitochondria, Heart; Muscle Contraction; Myocytes, Cardiac; Pluripotent Stem Cells; Quinoxalines; Spiro Compounds; Toluene; Up-Regulation	2018
Neuroprotective effects of pifithrin-α against traumatic brain injury in the striatum through suppression of neuroinflammation, oxidative stress, autophagy, and apoptosis. Scientific reports, 2018, 02-05, Volume: 8, Issue:1 Topics: Animals; Apoptosis; Autophagy; Benzothiazoles; Blotting, Western; Brain Injuries, Traumatic; Disease Models, Animal; Gene Expression Profiling; Gene Expression Regulation; Inflammation; Neuroglia; Neurons; Neuroprotective Agents; Oxidative Stress; Rats, Sprague-Dawley; Toluene; Treatment Outcome; Tumor Suppressor Protein p53; Ventral Striatum	2018
Inhibition of Heat Shock proteins HSP90 and HSP70 induce oxidative stress, suppressing cotton fiber development. Scientific reports, 2018, 02-26, Volume: 8, Issue:1 Topics: Benzothiazoles; Cotton Fiber; Gene Expression Regulation, Plant; Gossypium; HSP70 Heat-Shock Proteins; HSP90 Heat-Shock Proteins; Novobiocin; Oxidative Stress; Plant Proteins; Sulfonamides; Toluene	2018
Exposure of human melanocytes to UVB twice and subsequent incubation leads to cellular senescence and senescence-associated pigmentation through the prolonged p53 expression. Journal of dermatological science, 2018, Volume: 90, Issue:3 Topics: Apoptosis; Benzothiazoles; Cell Proliferation; Cells, Cultured; Cellular Senescence; Epidermal Cells; Epidermis; Humans; Infant, Newborn; Male; Melanins; Melanocytes; Skin Aging; Skin Pigmentation; Toluene; Tumor Suppressor Protein p53; Ultraviolet Rays	2018
Does p53 Inhibition Suppress Myocardial Ischemia-Reperfusion Injury? Journal of cardiovascular pharmacology and therapeutics, 2018, Volume: 23, Issue:4 Topics: Animals; Benzothiazoles; Disease Models, Animal; Male; Mice, Inbred C57BL; Mice, Knockout; Myocardial Contraction; Myocardial Infarction; Myocardial Reperfusion Injury; Myocytes, Cardiac; Necrosis; Sulfonamides; Time Factors; Toluene; Tumor Suppressor Protein p53; Ventricular Function, Left	2018
Sequential combined Treatment of Pifithrin-α and Posiphen Enhances Neurogenesis and Functional Recovery After Stroke. Cell transplantation, 2018, Volume: 27, Issue:4 Topics: Animals; Atrophy; Benzothiazoles; Cell Differentiation; Cell Proliferation; Cell Self Renewal; Cell Survival; Cells, Cultured; Cognition; Drug Therapy, Combination; Lateral Ventricles; Male; Mice, Inbred C57BL; Microtubule-Associated Proteins; Motor Activity; Neural Stem Cells; Neurogenesis; Physostigmine; Recovery of Function; Spheroids, Cellular; Stroke; Toluene	2018
MiR-125b blocks Bax/Cytochrome C/Caspase-3 apoptotic signaling pathway in rat models of cerebral ischemia-reperfusion injury by targeting p53. Neurological research, 2018, Volume: 40, Issue:10 Topics: Animals; Apoptosis; bcl-2-Associated X Protein; Benzothiazoles; Brain Infarction; Brain Ischemia; Caspase 3; Caspases; Cytochromes c; Disease Models, Animal; Enzyme Inhibitors; Gene Expression Regulation; Male; MicroRNAs; Phosphopyruvate Hydratase; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Signal Transduction; Toluene; Tumor Suppressor Protein p53	2018
High COX-2 expression contributes to a poor prognosis through the inhibition of chemotherapy-induced senescence in nasopharyngeal carcinoma. International journal of oncology, 2018, Volume: 53, Issue:3 Topics: Animals; Antineoplastic Agents; Benzothiazoles; Biomarkers, Tumor; Carcinoma; Cell Line, Tumor; Cell Proliferation; Cellular Senescence; Cyclooxygenase 2; Drug Resistance, Neoplasm; Female; Fibroblasts; Gene Expression Profiling; Humans; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Knockout; Mice, Nude; Middle Aged; Nasopharyngeal Carcinoma; Nasopharyngeal Neoplasms; Neoplasm Recurrence, Local; Primary Cell Culture; RNA Interference; RNA, Small Interfering; Specific Pathogen-Free Organisms; Survival Analysis; Toluene; Tumor Suppressor Protein p53	2018
Transient p53 inhibition sensitizes aged white adipose tissue for beige adipocyte recruitment by blocking mitophagy. FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2019, Volume: 33, Issue:1 Topics: Adipocytes, Beige; Adiponectin; Adipose Tissue, White; Adiposity; Aging; Animals; Benzothiazoles; Cells, Cultured; Cold Temperature; Energy Metabolism; Insulin Resistance; Mice; Mice, Inbred C57BL; Mice, Knockout; Mitochondria; Mitophagy; Sirolimus; Toluene; Tumor Suppressor Protein p53	2019
Tumor suppressor protein p53 negatively regulates ischemia-induced angiogenesis and arteriogenesis. Journal of vascular surgery, 2018, Volume: 68, Issue:6S Topics: Angiogenesis Inducing Agents; Angiogenesis Inhibitors; Animals; Benzothiazoles; Blood Flow Velocity; Collateral Circulation; Disease Models, Animal; Endothelial Cells; Hindlimb; Hypoxia-Inducible Factor 1, alpha Subunit; Mice, 129 Strain; Mice, Inbred C57BL; Mice, Knockout; Muscle, Skeletal; Neovascularization, Physiologic; Quinacrine; Regional Blood Flow; Reperfusion Injury; Signal Transduction; Tissue Culture Techniques; Toluene; Tumor Suppressor Protein p53; Vascular Endothelial Growth Factor A	2018
Resveratrol inhibited the progression of human hepatocellular carcinoma by inducing autophagy via regulating p53 and the phosphoinositide 3‑kinase/protein kinase B pathway. Oncology reports, 2018, Volume: 40, Issue:5 Topics: Adenine; Antineoplastic Agents, Phytogenic; Apoptosis; Autophagy; Benzothiazoles; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Movement; Cell Proliferation; Dose-Response Relationship, Drug; Humans; Liver Neoplasms; Phosphatidylinositol 3-Kinases; Phosphorylation; Proto-Oncogene Proteins c-akt; Resveratrol; Signal Transduction; Stilbenes; Toluene; Tumor Suppressor Protein p53; Up-Regulation	2018
Novel Role of p53 in Septic Immunosuppression: Involvement in Loss and Dysfunction of CD4+ T Lymphocytes. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 2018, Volume: 51, Issue:1 Topics: Animals; Apoptosis; Benzothiazoles; CD4-Positive T-Lymphocytes; Disease Models, Animal; Humans; Jurkat Cells; Lipopolysaccharides; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; RNA Interference; RNA, Small Interfering; Sepsis; Survival Rate; Toluene; Tumor Suppressor Protein p53; Up-Regulation	2018
Pifithrin-α enhancing anticancer effect of topotecan on p53-expressing cancer cells. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 2019, Feb-01, Volume: 128 Topics: Antineoplastic Agents; Benzothiazoles; Cell Line, Tumor; Cell Survival; DNA Damage; Dose-Response Relationship, Drug; Drug Therapy, Combination; Gene Expression Regulation, Neoplastic; Humans; Molecular Structure; Toluene; Topotecan; Tumor Suppressor Protein p53	2019
Acute kidney injury induces dramatic p21 upregulation via a novel, glucocorticoid-activated, pathway. American journal of physiology. Renal physiology, 2019, 04-01, Volume: 316, Issue:4 Topics: Acute Kidney Injury; Animals; Benzothiazoles; Cyclin-Dependent Kinase Inhibitor p21; Dexamethasone; Glucocorticoids; Glycerol; Hormone Antagonists; Hydrocortisone; Kidney Cortex; Male; Mice; Mifepristone; Signal Transduction; Toluene; Tumor Suppressor Protein p53; Up-Regulation	2019
Inhibition of P53/miR-34a improves diabetic endothelial dysfunction via activation of SIRT1. Journal of cellular and molecular medicine, 2019, Volume: 23, Issue:5 Topics: Animals; Benzothiazoles; Carbazoles; Cells, Cultured; Diabetes Mellitus, Experimental; Endothelial Cells; Endothelium, Vascular; Enzyme Activation; Gene Expression Regulation; Glucose; Male; Mice, Inbred C57BL; MicroRNAs; RNA Interference; Sirtuin 1; Toluene; Tumor Suppressor Protein p53	2019
Porcine epidemic diarrhea virus infections induce apoptosis in Vero cells via a reactive oxygen species (ROS)/p53, but not p38 MAPK and SAPK/JNK signalling pathways. Veterinary microbiology, 2019, Volume: 232 Topics: Acetylcysteine; Animals; Apoptosis; Benzothiazoles; Chlorocebus aethiops; MAP Kinase Signaling System; p38 Mitogen-Activated Protein Kinases; Porcine epidemic diarrhea virus; Pyrrolidines; Reactive Oxygen Species; Thiocarbamates; Toluene; Tumor Suppressor Protein p53; Vero Cells	2019
Pifithrin-Alpha Reduces Methamphetamine Neurotoxicity in Cultured Dopaminergic Neurons. Neurotoxicity research, 2019, Volume: 36, Issue:2 Topics: Animals; Benzothiazoles; Cell Line, Tumor; Cells, Cultured; Central Nervous System Stimulants; Dopaminergic Neurons; Endoplasmic Reticulum Stress; Female; Humans; Methamphetamine; Pregnancy; Rats; Toluene	2019
p53 induces miR-199a-3p to suppress mechanistic target of rapamycin activation in cisplatin-induced acute kidney injury. Journal of cellular biochemistry, 2019, Volume: 120, Issue:10 Topics: Acute Kidney Injury; Animals; Apoptosis; Benzothiazoles; Cell Proliferation; Cisplatin; Drug Resistance, Neoplasm; Epithelial Cells; Gene Expression Regulation, Neoplastic; Humans; Kidney Tubules; Mice; MicroRNAs; Neoplasms; Toluene; TOR Serine-Threonine Kinases; Tumor Suppressor Protein p53; Xenograft Model Antitumor Assays	2019
A Cancer Invasion Model Combined with Cancer-Associated Fibroblasts Aggregates Incorporating Gelatin Hydrogel Microspheres Containing a p53 Inhibitor. Tissue engineering. Part C, Methods, 2019, Volume: 25, Issue:12 Topics: Benzothiazoles; Cancer-Associated Fibroblasts; Cell Line, Tumor; Gelatin; Humans; Hydrogels; Microspheres; Models, Biological; Neoplasm Invasiveness; Neoplasms; Toluene; Tumor Suppressor Protein p53	2019
Inhibition of mTOR Signaling Enhances Maturation of Cardiomyocytes Derived From Human-Induced Pluripotent Stem Cells via p53-Induced Quiescence. Circulation, 2020, 01-28, Volume: 141, Issue:4 Topics: Benzothiazoles; Cell Line; Humans; Imidazoles; Induced Pluripotent Stem Cells; Myocytes, Cardiac; Naphthyridines; Piperazines; Toluene; TOR Serine-Threonine Kinases; Tumor Suppressor Protein p53; Wnt Signaling Pathway	2020
The p53 inactivators pifithrin-μ and pifithrin-α mitigate TBI-induced neuronal damage through regulation of oxidative stress, neuroinflammation, autophagy and mitophagy. Experimental neurology, 2020, Volume: 324 Topics: Animals; Antioxidants; Autophagy; Behavior, Animal; Benzothiazoles; Brain Contusion; Brain Injuries, Traumatic; Cytokines; Encephalitis; Heme Oxygenase (Decyclizing); Male; Mitophagy; Neurons; Neuroprotective Agents; Oxidative Stress; Rats; Rats, Sprague-Dawley; Sulfonamides; Toluene; Tumor Suppressor Protein p53	2020
Sesamin suppresses NSCLC cell proliferation and induces apoptosis via Akt/p53 pathway. Toxicology and applied pharmacology, 2020, 01-15, Volume: 387 Topics: Animals; Apoptosis; Benzothiazoles; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Proliferation; Chromones; Dioxoles; Female; G1 Phase Cell Cycle Checkpoints; Humans; Lignans; Lung Neoplasms; Mice; Morpholines; Proto-Oncogene Proteins c-akt; Signal Transduction; Toluene; Tumor Suppressor Protein p53; Xenograft Model Antitumor Assays	2020
Mode of action of carboplatin via activating p53/miR-145 axis in head and neck cancers. The Laryngoscope, 2020, Volume: 130, Issue:12 Topics: Benzothiazoles; Blotting, Western; Carboplatin; Carcinoma, Squamous Cell; Cell Line, Tumor; Cell Proliferation; Head and Neck Neoplasms; Humans; MicroRNAs; Reverse Transcriptase Polymerase Chain Reaction; Toluene; Transfection; Tumor Suppressor Protein p53	2020
Pifithrin-α alters p53 post-translational modifications pattern and differentially inhibits p53 target genes. Scientific reports, 2020, 01-23, Volume: 10, Issue:1 Topics: Apoptosis; Basic Helix-Loop-Helix Transcription Factors; Benzothiazoles; Cell Cycle; Cell Line, Tumor; Cell Proliferation; HCT116 Cells; Humans; Imidazoles; MCF-7 Cells; NF-E2-Related Factor 2; Piperazines; Protein Processing, Post-Translational; Proto-Oncogene Proteins c-mdm2; Reactive Oxygen Species; Receptors, Aryl Hydrocarbon; RNA Interference; RNA, Small Interfering; Toluene; Transcription, Genetic; Tumor Suppressor Protein p53	2020
Lobetyolin induces apoptosis of colon cancer cells by inhibiting glutamine metabolism. Journal of cellular and molecular medicine, 2020, Volume: 24, Issue:6 Topics: Amino Acid Transport System ASC; Animals; Antineoplastic Agents; Apoptosis; Benzothiazoles; Cell Line, Tumor; Colonic Neoplasms; Glutamine; HCT116 Cells; Humans; Mice; Mice, Nude; Minor Histocompatibility Antigens; Polyynes; Toluene; Tumor Suppressor Protein p53	2020
Bilayer pifithrin-α loaded extracellular matrix/PLGA scaffolds for enhanced vascularized bone formation. Colloids and surfaces. B, Biointerfaces, 2020, Volume: 190 Topics: 3T3 Cells; Animals; Benzothiazoles; Bone Regeneration; Cell Proliferation; Cells, Cultured; Extracellular Matrix; Lipid Bilayers; Mice; Particle Size; Polylactic Acid-Polyglycolic Acid Copolymer; Surface Properties; Tissue Engineering; Toluene	2020
THOC1 deficiency leads to late-onset nonsyndromic hearing loss through p53-mediated hair cell apoptosis. PLoS genetics, 2020, Volume: 16, Issue:8 Topics: Animals; Apoptosis; Benzothiazoles; CRISPR-Associated Protein 9; Deafness; Disease Models, Animal; DNA-Binding Proteins; Exome Sequencing; Gene Expression Regulation; Gene Knockout Techniques; Hair Cells, Auditory; Hair Cells, Auditory, Inner; Humans; Mice; Mutation; RNA-Binding Proteins; RNA, Guide, Kinetoplastida; Signal Transduction; Toluene; Tumor Suppressor Protein p53; Zebrafish	2020
Phenotypic and Functional Characteristics of a Novel Influenza Virus Hemagglutinin-Specific Memory NK Cell. Journal of virology, 2021, 05-24, Volume: 95, Issue:12 Topics: Adoptive Transfer; Animals; Antigens, Ly; Benzothiazoles; CD8-Positive T-Lymphocytes; Coculture Techniques; Cytotoxicity, Immunologic; Dendritic Cells; Hemagglutinin Glycoproteins, Influenza Virus; Immunologic Memory; Influenza A Virus, H1N1 Subtype; Influenza A Virus, H9N2 Subtype; Interferon-gamma; Killer Cells, Natural; Mice; Mice, Inbred C57BL; Natural Cytotoxicity Triggering Receptor 1; NK Cell Lectin-Like Receptor Subfamily C; Orthomyxoviridae Infections; Spleen; Toluene	2021
Regulation of amyloid-β levels by matrix metalloproteinase-2/9 (MMP2/9) in the media of lung cancer cells. Scientific reports, 2021, 05-06, Volume: 11, Issue:1 Topics: Amyloid beta-Peptides; Antibodies, Monoclonal; Benzothiazoles; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Culture Media, Conditioned; Humans; Hyaluronan Receptors; Hymecromone; Lung Neoplasms; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; NF-kappa B; RNA, Small Interfering; Toluene	2021
P53 inhibitor pifithrin-α inhibits ropivacaine-induced neuronal apoptosis via the mitochondrial apoptosis pathway. Journal of biochemical and molecular toxicology, 2021, Volume: 35, Issue:8 Topics: Animals; Apoptosis; Benzothiazoles; Mitochondria; PC12 Cells; Rats; Rats, Sprague-Dawley; Ropivacaine; Spinal Cord Injuries; Toluene; Tumor Suppressor Protein p53	2021
Application of P53 mRNA in signal transduction mechanisms of skeletal muscle cells. Pakistan journal of pharmaceutical sciences, 2021, Volume: 34, Issue:1(Special) Topics: Animals; Benzothiazoles; Mice; Mice, Inbred ICR; Muscle Fibers, Skeletal; Muscle, Skeletal; Physical Conditioning, Animal; RNA, Messenger; Signal Transduction; Sulfonamides; Toluene; Tumor Suppressor Protein p53	2021
Role of JNK and p53 in Implementation of Functions of Various Types of Regeneration-Competent Cells of the Nervous Tissue. Bulletin of experimental biology and medicine, 2021, Volume: 171, Issue:3 Topics: Animals; Astrocytes; Benzothiazoles; CD56 Antigen; Culture Media, Conditioned; Gene Expression Regulation; Lateral Ventricles; MAP Kinase Kinase 4; Mice; Mice, Inbred C57BL; Multipotent Stem Cells; Nerve Growth Factors; Neural Cell Adhesion Molecules; Neural Stem Cells; Neuroglia; Signal Transduction; Toluene; Tumor Suppressor Protein p53	2021
ER stress-induced modulation of neural activity and seizure susceptibility is impaired in a fragile X syndrome mouse model. Neurobiology of disease, 2021, Volume: 158 Topics: Animals; Benzothiazoles; Endoplasmic Reticulum Stress; Fragile X Mental Retardation Protein; Fragile X Syndrome; Genetic Predisposition to Disease; Kainic Acid; Mice; Mice, Inbred C57BL; Mice, Knockout; Nerve Net; Patch-Clamp Techniques; Seizures; Toluene; Tumor Suppressor Protein p53	2021
Identification of neural oscillations and epileptiform changes in human brain organoids. Nature neuroscience, 2021, Volume: 24, Issue:10 Topics: Adult; Benzothiazoles; Brain; Calcium Signaling; Child, Preschool; Epilepsy; Female; Humans; Induced Pluripotent Stem Cells; Methyl-CpG-Binding Protein 2; Nerve Net; Neurogenesis; Neuroimaging; Neurons; Rett Syndrome; Single-Cell Analysis; Synapses; Toluene; Transcriptome	2021
Urea transporter B downregulates polyamines levels in melanoma B16 cells via p53 activation. Biochimica et biophysica acta. Molecular cell research, 2022, Volume: 1869, Issue:5 Topics: Acetylcysteine; Animals; Apoptosis; Benzothiazoles; Cell Line, Tumor; Cell Proliferation; Down-Regulation; Melanoma, Experimental; Membrane Potential, Mitochondrial; Membrane Transport Proteins; Mice; Mitochondria; Nitric Oxide; Polyamines; Putrescine; Reactive Oxygen Species; Toluene; Tumor Suppressor Protein p53; Ubiquinone; Urea Transporters	2022
Pifithrin-α ameliorates glycerol induced rhabdomyolysis and acute kidney injury by reducing p53 activation. Renal failure, 2022, Volume: 44, Issue:1 Topics: Acute Kidney Injury; Animals; Benzothiazoles; Glycerol; Mice; Mice, Inbred C57BL; Rhabdomyolysis; Toluene; Tumor Suppressor Protein p53	2022
PFT-α inhibits gallid alpha herpesvirus 1 replication by repressing host nucleotide metabolism and ATP synthesis. Veterinary microbiology, 2022, Volume: 269 Topics: Adenosine Triphosphate; Animals; Benzothiazoles; Chickens; Herpesviridae Infections; Herpesvirus 1, Gallid; Nucleotides; Poultry Diseases; Toluene	2022
SIRT1720 promotes survival of corneal epithelial cells via the P53 pathway. Journal of population therapeutics and clinical pharmacology = Journal de la therapeutique des populations et de la pharmacologie clinique, 2022, Volume: 29, Issue:3 Topics: Benzothiazoles; Epithelial Cells; Heterocyclic Compounds, 4 or More Rings; Humans; Hydrogen Peroxide; Niacinamide; Sirtuin 1; Toluene; Tumor Suppressor Protein p53	2022