Page last updated: 2024-08-16

pifithrin and thiazoles

pifithrin has been researched along with thiazoles in 83 studies

Research

Studies (83)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	3 (3.61)	18.2507
2000's	79 (95.18)	29.6817
2010's	1 (1.20)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Chernov, MV; Christov-Tselkov, K; Coon, JS; Gudkov, AV; Komarov, PG; Komarova, EA; Kondratov, RV	1
Ferber, D	1
Jacquemin-Sablon, A	1
Grosu, AL; Molls, M; Stadler, P	1
Gudkov, AV; Komarova, EA	2
Howell, SB	1
Camandola, S; Chan, SL; Culmsee, C; Greig, NH; Guo, Z; Mattson, MP; Yu, QS; Zhu, X	1
Dubinsky, JM; Lakkaraju, A; Low, WC; Rahman, YE	1
Mahyar-Roemer, M; Roemer, K	1
Hernández, G; López-Rivas, A; Lorenzo, E; Quesada, AJ; Redondo, JM; Rodríguez, A; Ruiz-Ruiz, C	1
Chopin, V; Jouy, N; Le Bourhis, X; Toillon, RA	1
Akin, D; Cohen, RJ; Feldherr, CM	1
Bassi, L; Carloni, M; Fonti, E; Meschini, R; Palitti, F; Palma de la Peña, N	1
Horal, M; Loeken, MR; Pani, L	1
Begum, RA; Farah, IO; Ishaque, AB	1
Arai, M; Fujiwara, K; Ikeda, H; Inoue, Y; Kimura, S; Ogata, I; Omata, M; Tejima, K; Tomiya, T; Yanase, M	1
Bruch, HP; El-Gibaly, AM; Menger, MD; Scheuer, C; Strik, MW; Vollmar, B	1
Dabrowska-Iwanicka, A; Giermasz, A; Golab, J; Grzela, T; Hoser, G; Jakóbisiak, M; Jalili, A; Makowski, M; Marczak, M; Olszewska, D	1
Cadet, JL; Cutler, RG; Duan, W; Greig, NH; Guo, Z; Ladenheim, B; Mattson, MP; Oyler, J; Yu, QS; Zhu, X	1
Gong, Q; Hollmann, AC; Owens, T	1
Dagher, PC; Kelly, KJ; Plotkin, Z; Vulgamott, SL	1
Lin, Y; Waldman, AS; Waldman, BC	1
Bartholomew, J; Char, D; Cleaver, JE; Crowley, E; Feeney, L; Limoli, CL	1
Alves da Costa, C; Ancolio, K; Checler, F; Mattson, MP	1
Chernov, MV; Gudkov, AV; Komarov, PG; Komarova, EA; Neznanov, N; Wang, K	1
Menger, MD; Roemer, K; Schäfer, T; Scheuer, C; Vollmar, B	1
Campana, AL; Falempin, M; Lohof, AM; Mariani, J; Picquet, F; Rondi-Reig, L; Tobin, C; Weitzman, JB	1
Bardini, P; Danni, O; Guglielmotto, M; Marra, L; Parola, M; Santoro, G; Tabaton, M; Tamagno, E	1
Chan, SL; Gilman, CP; Greig, N; Guo, Z; Mattson, MP; Zhu, X	1
Ding, D; Liu, W; Salvi, R; Zhang, M	1
Akimitsu, N; Hamamoto, H; Kamura, K; Kikuchi, A; Sakaguchi, A; Sekimizu, K; Toné, S	1
Bode, AM; Dong, Z; Kaji, A; Ma, WY; Nomura, M; She, QB; Zhang, Y	1
Balajee, AS; Lorenti Garcia, C; Palitti, F; Pepe, G; Proietti De Santis, L; Worboys, AM	1
Bet, A; Carli, M; Dalla Vecchia, F; Diaspro, A; Gatto, B; Palù, G; Palumbo, M; Pecere, T; Salata, C; Sarinella, F	1
Campbell, KJ; Perkins, ND; Rocha, S; Roche, KC	1
Behnke, H; Camandola, S; Culmsee, C; El-Metainy, S; Junker, V; Krieglstein, J; Mattson, MP; Retiounskaia, M; Schwarz, S; Siewe, J	1
Mocanu, MM; Yellon, DM	1
Bonini, P; Cardinale, A; Cicconi, S; Ciotti, MT; Marlier, LN; Serafino, AL; Vitale, C	1
Nakashima, K; Nakaso, K; Takeshima, T; Yano, H; Yoshimoto, Y	1
Chen, Z; Chua, BH; Chua, CC; Gao, J; Hamdy, R; Landy, CL; Liu, X	1
Dimanche-Boitrel, MT; Fardel, O; Gardyn, C; Gilot, D; Guillouzo, A; Huc, L; Lagadic-Gossmann, D; Rissel, M	1
Christov, K; Goldblum, JR; Golovkina, TV; Gudkov, AV; Komarova, EA; Kondratov, RV; Wang, K	1
Aharonowiz, M; Greig, NH; Leker, RR; Ovadia, H	1
Galigniana, MD; Harrell, JM; Kwok, RP; Ljungman, M; Morishima, Y; Murphy, PJ; Pratt, WB	1
El-Gibaly, AM; Menger, MD; Scheuer, C; Vollmar, B	1
Hu, H; Jiang, C; Lü, J; Malewicz, B; Wang, Z	1
Dong, Z; Hsu, S; Jiang, M; Wang, CY; Yi, X	1
Golovko, O; Lou, YR; Nazarova, N; Qiao, S; Tuohimaa, P	1
Chao, JI; Kuo, PC; Liu, HF	1
Daida, H; Kashiwakura, Y; Kumon, H; Kusumi, N; Nasu, Y; Sawamura, T; Sumiyoshi, K; Takei, K; Watanabe, M; Yamada, H	1
Boltze, C; Diab-Assef, M; Foltzer-Jourdainne, C; Gali-Muhtasib, H; Hartig, R; Roessner, A; Rohrbeck, A; Schneider-Stock, R; Schönfeld, P	1
Kozubík, A; Machala, M; Plísková, M; Vojtesek, B; Vondrácek, J	1
Csapo, Z; Keszler, G; Sasvari-Szekely, M; Spasokoukotskaja, T; Staub, M; Virga, S	1
Engelstein, R; Gabizon, R; Greig, NH; Grigoriadis, N; Ovadia, H	1
Colohan, AR; Yamaguchi, M; Zhang, JH; Zhou, C	1
Burlet, S; Dono, R; Garino, C; Kraus, JL; Laras, Y; Maina, F; Moumen, A; Pietrancosta, N; Quéléver, G	1
Barchéchath, SD; Carson, DA; Corr, M; Cottam, HB; Tawatao, RI	2
Benbrook, DM; Gould, NS; Guruswamy, S; Kamelle, SA; Rutledge, TL; Tillmanns, TD	1
Cairncross, JG; Mymryk, JS; Xu, GW	1
Hoagland, EM; Hoagland, MS; Swanson, HI	1
Kaushal, GP; Kaushal, V; Seth, R; Shah, SV; Yang, C	1
He, J; Huang, C; Li, J; Ma, Q; Ouyang, W; Tong, Q; Wang, J; Wei, L; Zhang, Z	1
Bordel, R; Eipel, C; Glawe, C; Menger, MD; Schuett, H; Vollmar, B	1
Hardcastle, IR; Mirza, AR; Walton, MI; Wilson, SC; Workman, P	1
Chechlacz, M; Gilliams-Francis, K; Lamonica, K; Lin, SL; Liu, J; Naegele, JR; Navarro-Quiroga, I; Neema, M	1
Aninat, C; Fardel, O; Le Vee, M; Sparfel, L; Van Grevenynghe, J	1
Chan, SL; Chan, SS; Fiscus, RR; Fraser, M; Tsang, BK	1
Chandel, N; Kamp, DW; Panduri, V; Soberanes, S; Surapureddi, S; Weitzman, SA	1
Jimenez Del Rio, M; Velez-Pardo, C	1
Chie, EK; Ha, SW; Kao, GD; Kim, IA; Kim, IH; Kim, JH; Kim, JS; Park, CI; Shin, JH; Wu, HG	1
Charlot, JF; Mougin, C; Nicolier, M; Prétet, JL	1
Cheng, XY; Ji, L; Luan, B; Qiu, L; Wang, XY; Xu, FL; Zhu, CL	1
Nedelcu, AM	1
Chua, BH; Chua, CC; Gao, J; Hamdy, RC; Liu, X	1
Cahill, J; Calvert, JW; Solaroglu, I; Zhang, JH	1
Bähr, M; Dono, R; Kraus, JL; Lamballe, F; Lingor, P; Maina, F; Moumen, A; Pietrancosta, N; Planchamp, V	1
Maki, K; Mitani, K; Waga, K; Yamagata, T	1
Arai, N; Fujishita, T; Fujita, T; Hayashi, R; Kawagishi, Y; Kobayashi, M; Maruyama, M; Matsui, S; Miwa, T; Miyabayashi, K; Shinoda, C; Sugiyama, E; Yamada, T	1
Bosykh, DA; Burdelya, LG; Chernova, OB; Gudkov, AV; Komarov, PG; Komarova, EA; Macklis, RM; Pavlovska, I; Sathe, S; Shyshynova, I; Skaliter, R; Strom, E	1
Browder, T; Burdelya, LG; DiCorleto, PE; Folkman, J; Gudkov, AV; Hill, JE; Komarova, EA; Mavrakis, L; Tararova, ND	1
Cai, X; Chen, Q; Du, J; Hou, J; Li, D; Li, Y; Pan, G; Shan, Y; Shen, Q; Shi, X; Wang, L; Wang, X; Zhang, H; Zhang, T; Zhou, T	1

Reviews

3 review(s) available for pifithrin and thiazoles

Article	Year
Suppression of p53: a new approach to overcome side effects of antitumor therapy. Biochemistry. Biokhimiia, 2000, Volume: 65, Issue:1 Topics: Animals; Antineoplastic Agents; Apoptosis; Benzothiazoles; Gene Expression Regulation, Neoplastic; Genes, Tumor Suppressor; Humans; Mice; Mice, Transgenic; Neoplasms; Thiazoles; Toluene; Tumor Cells, Cultured; Tumor Suppressor Protein p53	2000
Resistance to apoptosis in prostate cancer cells. Molecular urology, 2000,Fall, Volume: 4, Issue:3 Topics: Androgen Antagonists; Androgens; Apoptosis; Benzothiazoles; Caspases; DNA Repair; Drug Resistance, Neoplasm; Enzyme Activation; Humans; Male; Micrococcus; Prostatic Neoplasms; Thiazoles; Toluene; Tumor Suppressor Protein p53	2000
Prospective therapeutic applications of p53 inhibitors. Biochemical and biophysical research communications, 2005, Jun-10, Volume: 331, Issue:3 Topics: Animals; Antineoplastic Agents; Apoptosis; Benzothiazoles; Drug Synergism; Humans; Neurodegenerative Diseases; Neuroprotective Agents; Radiation-Protective Agents; Thiazoles; Toluene; Tumor Suppressor Protein p53	2005

Other Studies

80 other study(ies) available for pifithrin and thiazoles

Article	Year
A chemical inhibitor of p53 that protects mice from the side effects of cancer therapy. Science (New York, N.Y.), 1999, Sep-10, Volume: 285, Issue:5434 Topics: Animals; Antineoplastic Agents; Apoptosis; Benzothiazoles; Cell Division; Cell Line; Cell Nucleus; Cytoplasm; DNA; DNA Damage; G2 Phase; Gamma Rays; Humans; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Nude; Neoplasms; Radiation Tolerance; Thiazoles; Time Factors; Toluene; Tumor Cells, Cultured; Tumor Suppressor Protein p53; Ultraviolet Rays	1999
Cancer research. A new way to combat therapy side effects. Science (New York, N.Y.), 1999, Sep-10, Volume: 285, Issue:5434 Topics: Animals; Antineoplastic Agents; Apoptosis; Benzothiazoles; Cell Division; Cells, Cultured; Drug Evaluation, Preclinical; Gamma Rays; Humans; Mice; Neoplasms; Radiation Dosage; Radiation Tolerance; Thiazoles; Toluene; Tumor Suppressor Protein p53	1999
[PFTalpha, guardian of the sick?]. Bulletin du cancer, 1999, Volume: 86, Issue:11 Topics: Animals; Antineoplastic Agents; Apoptosis; Benzothiazoles; Cell Cycle; DNA Damage; DNA Repair; DNA, Neoplasm; Mice; Mutation; Thiazoles; Toluene; Tumor Suppressor Protein p53	1999
[A chemical inhibitor of p53 that protects mice from the side effects of cancer treatment]. Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al], 2000, Volume: 176, Issue:2 Topics: Animals; Antineoplastic Agents; Benzothiazoles; Combined Modality Therapy; Drug Evaluation, Preclinical; Mice; Neoplasms, Experimental; Radiotherapy; Thiazoles; Toluene; Tumor Cells, Cultured; Tumor Suppressor Protein p53	2000
A synthetic inhibitor of p53 protects neurons against death induced by ischemic and excitotoxic insults, and amyloid beta-peptide. Journal of neurochemistry, 2001, Volume: 77, Issue:1 Topics: Amyloid beta-Peptides; Animals; Antineoplastic Agents; Benzothiazoles; Brain Ischemia; Caspase 3; Caspases; Cell Death; Cell Survival; Cells, Cultured; Disease Models, Animal; DNA; Dose-Response Relationship, Drug; Glutamic Acid; Kainic Acid; Mice; Mice, Inbred C57BL; Mitochondria; Neurons; Prodrugs; Rats; Rats, Sprague-Dawley; Seizures; Thiazoles; Toluene; Tumor Suppressor Protein p53	2001
Neurons are protected from excitotoxic death by p53 antisense oligonucleotides delivered in anionic liposomes. The Journal of biological chemistry, 2001, Aug-24, Volume: 276, Issue:34 Topics: Animals; Anions; Base Sequence; Benzothiazoles; Cell Death; Cell Line; Cricetinae; DNA Primers; Drug Carriers; Excitatory Amino Acid Antagonists; Glutamic Acid; Humans; Liposomes; Neurons; Neuroprotective Agents; Oligonucleotides, Antisense; Osmolar Concentration; Rats; Thiazoles; Toluene; Tumor Suppressor Protein p53	2001
p21 Waf1/Cip1 can protect human colon carcinoma cells against p53-dependent and p53-independent apoptosis induced by natural chemopreventive and therapeutic agents. Oncogene, 2001, Jun-07, Volume: 20, Issue:26 Topics: Adenocarcinoma; Alleles; Amino Acid Chloromethyl Ketones; Anticarcinogenic Agents; Antineoplastic Agents; Apoptosis; Benzothiazoles; Butyrates; Cisplatin; Colonic Neoplasms; Cyclin-Dependent Kinase Inhibitor p21; Cyclins; Cysteine Proteinase Inhibitors; Demecolcine; Doxorubicin; Drug Resistance, Neoplasm; Etoposide; Fluorouracil; Gene Expression Regulation, Neoplastic; Genes, p53; Humans; Intracellular Membranes; Membrane Potentials; Mitochondria; Neoplasm Proteins; Recombination, Genetic; Resveratrol; Stilbenes; Thiazoles; Toluene; Tumor Cells, Cultured; Tumor Suppressor Protein p53	2001
Doxorubicin induces apoptosis and CD95 gene expression in human primary endothelial cells through a p53-dependent mechanism. The Journal of biological chemistry, 2002, Mar-29, Volume: 277, Issue:13 Topics: Apoptosis; Base Sequence; Benzothiazoles; Cell Division; Cells, Cultured; DNA Primers; Doxorubicin; Endothelium, Vascular; fas Receptor; Fluorescent Antibody Technique; Gene Expression Regulation; Humans; Promoter Regions, Genetic; Thiazoles; Toluene; Tumor Suppressor Protein p53	2002
Sodium butyrate induces P53-independent, Fas-mediated apoptosis in MCF-7 human breast cancer cells. British journal of pharmacology, 2002, Volume: 135, Issue:1 Topics: Apoptosis; bcl-2-Associated X Protein; Benzothiazoles; Blotting, Western; Breast Neoplasms; Butyrates; Caspase Inhibitors; Cell Cycle; Cell Division; Fas Ligand Protein; fas Receptor; Humans; Membrane Glycoproteins; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Signal Transduction; Thiazoles; Toluene; Tumor Cells, Cultured; Tumor Suppressor Protein p53	2002
Regulation of functional nuclear pore size in fibroblasts. Journal of cell science, 2001, Volume: 114, Issue:Pt 24 Topics: 3T3 Cells; Active Transport, Cell Nucleus; Animals; Benzothiazoles; Cycloheximide; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Diffusion; Fibroblasts; Gold Colloid; Leupeptins; Mice; Multienzyme Complexes; Nuclear Localization Signals; Nuclear Pore; Proteasome Endopeptidase Complex; Thiazoles; Toluene; Tumor Suppressor Protein p53	2001
Pifithrin-alpha, an inhibitor of p53, enhances the genetic instability induced by etoposide (VP16) in human lymphoblastoid cells treated in vitro. Mutation research, 2002, Feb-20, Volume: 499, Issue:2 Topics: Antineoplastic Agents, Phytogenic; Benzothiazoles; Cell Cycle; Cell Survival; Chromosome Aberrations; DNA Fragmentation; Dose-Response Relationship, Drug; Drug Synergism; Etoposide; Flow Cytometry; Humans; In Vitro Techniques; Karyotyping; Lymphocytes; Thiazoles; Time Factors; Toluene; Tumor Cells, Cultured; Tumor Suppressor Protein p53	2002
Rescue of neural tube defects in Pax-3-deficient embryos by p53 loss of function: implications for Pax-3- dependent development and tumorigenesis. Genes & development, 2002, Mar-15, Volume: 16, Issue:6 Topics: Animals; Apoptosis; Benzothiazoles; Blotting, Western; DNA-Binding Proteins; Down-Regulation; Genes, p53; Genotype; Heterozygote; In Situ Nick-End Labeling; Mice; Mice, Inbred C57BL; Neural Crest; Neural Tube Defects; Paired Box Transcription Factors; PAX3 Transcription Factor; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Thiazoles; Time Factors; Toluene; Transcription Factors; Transcription, Genetic; Tumor Suppressor Protein p53	2002
Pifithrin-alpha (PFT-alpha) caused differential protection of rat liver cells and HepG2 cell line in response to the selective cytotoxicity of arsenic and cadmium. Biomedical sciences instrumentation, 2002, Volume: 38 Topics: Animals; Arsenic Trioxide; Arsenicals; Benzothiazoles; Cadmium Chloride; Cell Line; Cytoprotection; Dose-Response Relationship, Drug; Liver; Oxides; Rats; Rats, Wistar; Regression Analysis; Thiazoles; Toluene	2002
p53 May positively regulate hepatocyte proliferation in rats. Hepatology (Baltimore, Md.), 2002, Volume: 36, Issue:2 Topics: Animals; Antimetabolites; Benzothiazoles; Bromodeoxyuridine; Cell Division; Cells, Cultured; Hepatectomy; Hepatocyte Growth Factor; Hepatocytes; Male; Oligonucleotides, Antisense; Rats; Rats, Sprague-Dawley; Thiazoles; Toluene; Transforming Growth Factor alpha; Tumor Suppressor Protein p53	2002
Acceleration of cutaneous wound healing by transient p53 inhibition. Laboratory investigation; a journal of technical methods and pathology, 2002, Volume: 82, Issue:8 Topics: Animals; Benzothiazoles; Cell Division; Female; Male; Mice; Skin; Thiazoles; Toluene; Tumor Suppressor Protein p53; Wound Healing	2002
Augmented antitumour effects of combination therapy with TNP-470 and chemoimmunotherapy in mice. Journal of cancer research and clinical oncology, 2002, Volume: 128, Issue:8 Topics: Angiogenesis Inhibitors; Animals; Antineoplastic Agents; Benzothiazoles; Blotting, Western; Cell Division; Cisplatin; Colonic Neoplasms; Cyclin-Dependent Kinase Inhibitor p21; Cyclins; Cyclohexanes; Drug Synergism; Drug Therapy, Combination; Flow Cytometry; Immunotherapy; Interferon-gamma; Interleukin-12; Melanoma, Experimental; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Inbred DBA; Neovascularization, Pathologic; O-(Chloroacetylcarbamoyl)fumagillol; Sesquiterpenes; Tetrazolium Salts; Thiazoles; Toluene; Tumor Suppressor Protein p53	2002
p53 inhibitors preserve dopamine neurons and motor function in experimental parkinsonism. Annals of neurology, 2002, Volume: 52, Issue:5 Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Apoptosis; bcl-2-Associated X Protein; Behavior, Animal; Benzothiazoles; Dopamine; Dopamine Agents; Male; Mice; Mice, Inbred C57BL; Motor Activity; Neurons; Neuroprotective Agents; Parkinsonian Disorders; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Thiazoles; Toluene; Tumor Suppressor Protein p53	2002
CD40-mediated apoptosis in murine B-lymphoma lines containing mutated p53. Experimental cell research, 2002, Nov-01, Volume: 280, Issue:2 Topics: Animals; Apoptosis; B-Lymphocytes; Benzothiazoles; CD40 Antigens; DNA-Binding Proteins; Fas Ligand Protein; fas Receptor; Flow Cytometry; Genes, Reporter; I-kappa B Proteins; Lymphoma, B-Cell; Membrane Glycoproteins; Mice; NF-kappa B; NF-KappaB Inhibitor alpha; Point Mutation; Thiazoles; Toluene; Tumor Cells, Cultured; Tumor Suppressor Protein p53	2002
P53 mediates the apoptotic response to GTP depletion after renal ischemia-reperfusion: protective role of a p53 inhibitor. Journal of the American Society of Nephrology : JASN, 2003, Volume: 14, Issue:1 Topics: Animals; Apoptosis; bcl-2-Associated X Protein; Benzothiazoles; Cyclin-Dependent Kinase Inhibitor p21; Cyclins; Guanosine; Guanosine Triphosphate; Kidney; Kidney Cortex; Kidney Medulla; LLC-PK1 Cells; Male; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Rats; Rats, Sprague-Dawley; Renal Circulation; Reperfusion Injury; Swine; Thiazoles; Tissue Distribution; Toluene; Tumor Suppressor Protein p53	2003
Suppression of high-fidelity double-strand break repair in mammalian chromosomes by pifithrin-alpha, a chemical inhibitor of p53. DNA repair, 2003, Jan-02, Volume: 2, Issue:1 Topics: Animals; Benzothiazoles; Cell Line; DNA Repair; Fibroblasts; In Vitro Techniques; Mice; Thiazoles; Toluene; Tumor Suppressor Protein p53	2003
Polymerase eta and p53 jointly regulate cell survival, apoptosis and Mre11 recombination during S phase checkpoint arrest after UV irradiation. DNA repair, 2002, Jan-22, Volume: 1, Issue:1 Topics: Acid Anhydride Hydrolases; Apoptosis; Benzothiazoles; beta-Galactosidase; Blotting, Western; Cell Cycle Proteins; Cell Line, Transformed; Cell Survival; DNA Repair Enzymes; DNA Replication; DNA-Binding Proteins; DNA-Directed DNA Polymerase; Fibroblasts; Humans; MRE11 Homologue Protein; Nuclear Proteins; Oncogene Proteins, Viral; Recombination, Genetic; S Phase; Simian virus 40; Thiazoles; Toluene; Tumor Suppressor Protein p53; Ultraviolet Rays	2002
The C-terminal fragment of presenilin 2 triggers p53-mediated staurosporine-induced apoptosis, a function independent of the presenilinase-derived N-terminal counterpart. The Journal of biological chemistry, 2003, Apr-04, Volume: 278, Issue:14 Topics: Animals; Apoptosis; Benzothiazoles; Caspase 3; Caspases; Cells, Cultured; Dimerization; Enzyme Inhibitors; Fibroblasts; Gene Expression; Humans; Kidney; Membrane Proteins; Mice; Peptide Fragments; Phenotype; Presenilin-2; Protein Structure, Tertiary; Staurosporine; Thiazoles; Toluene; Tumor Suppressor Protein p53	2003
p53 inhibitor pifithrin alpha can suppress heat shock and glucocorticoid signaling pathways. The Journal of biological chemistry, 2003, May-02, Volume: 278, Issue:18 Topics: Animals; Benzothiazoles; DNA-Binding Proteins; Glucocorticoids; Heat Shock Transcription Factors; Heat-Shock Response; Mice; NF-kappa B; Receptors, Glucocorticoid; Signal Transduction; Thiazoles; Toluene; Transcription Factors; Tumor Suppressor Protein p53	2003
Inhibition of p53 protects liver tissue against endotoxin-induced apoptotic and necrotic cell death. FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2003, Volume: 17, Issue:6 Topics: Animals; Apoptosis; Benzothiazoles; Blotting, Western; Caspase 3; Caspases; Cell Nucleus; Cytoplasm; Female; Immunohistochemistry; Lipopolysaccharides; Liver; Male; Microscopy, Fluorescence; Necrosis; NF-kappa B; Rats; Rats, Sprague-Dawley; Thiazoles; Toluene; Transaminases; Tumor Suppressor Protein p53	2003
p53 inactivation leads to impaired motor synchronization in mice. The European journal of neuroscience, 2003, Volume: 17, Issue:10 Topics: Animals; Benzothiazoles; Cerebellum; Lameness, Animal; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Motor Activity; Motor Neurons; Muscle Fibers, Fast-Twitch; Muscle, Skeletal; Neuromuscular Junction; Olivary Nucleus; Organ Culture Techniques; Thiazoles; Toluene; Tumor Suppressor Protein p53; Walking	2003
Multiple signaling events in amyloid beta-induced, oxidative stress-dependent neuronal apoptosis. Free radical biology & medicine, 2003, Jul-01, Volume: 35, Issue:1 Topics: Acetylcysteine; alpha-Tocopherol; Amyloid beta-Peptides; Apoptosis; bcl-2-Associated X Protein; Benzothiazoles; Caspase 3; Caspases; Cell Differentiation; Cytochromes c; Enzyme Activation; Enzyme Inhibitors; Humans; Hydrogen Peroxide; JNK Mitogen-Activated Protein Kinases; MAP Kinase Kinase 4; Mitochondria; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Neuroblastoma; Oxidative Stress; p38 Mitogen-Activated Protein Kinases; Peptide Fragments; Poly(ADP-ribose) Polymerases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Thiazoles; Toluene; Tumor Cells, Cultured; Tumor Suppressor Protein p53	2003
p53 is present in synapses where it mediates mitochondrial dysfunction and synaptic degeneration in response to DNA damage, and oxidative and excitotoxic insults. Neuromolecular medicine, 2003, Volume: 3, Issue:3 Topics: Animals; Benzothiazoles; Brain; Cells, Cultured; DNA Damage; Etoposide; Membrane Potentials; Mice; Mitochondria; Neurodegenerative Diseases; Neuroprotective Agents; Neurotoxins; Nucleic Acid Synthesis Inhibitors; Oxidative Stress; Phosphorylation; Presynaptic Terminals; Reactive Oxygen Species; Synapsins; Synaptosomes; Thiazoles; Toluene; Tumor Suppressor Protein p53	2003
Pifithrin-alpha suppresses p53 and protects cochlear and vestibular hair cells from cisplatin-induced apoptosis. Neuroscience, 2003, Volume: 120, Issue:1 Topics: Animals; Apoptosis; Benzothiazoles; Cisplatin; Cochlea; Dose-Response Relationship, Drug; Hair Cells, Vestibular; Organ Culture Techniques; Rats; Rats, Inbred F344; Thiazoles; Toluene; Tumor Suppressor Protein p53	2003
Induction of apoptosis by depletion of DNA topoisomerase IIalpha in mammalian cells. Biochemical and biophysical research communications, 2003, Jul-25, Volume: 307, Issue:2 Topics: Animals; Antigens, Neoplasm; Antineoplastic Agents; Apoptosis; Benzothiazoles; Caspases; Cell Nucleus; Diketopiperazines; DNA Topoisomerases, Type II; DNA-Binding Proteins; Embryo, Mammalian; Enzyme Activation; Fluorescent Dyes; HeLa Cells; Humans; In Situ Nick-End Labeling; Mice; Mice, Knockout; Nocodazole; Piperazines; RNA, Small Interfering; Thiazoles; Toluene; Topoisomerase II Inhibitors	2003
Pifithrin-alpha promotes p53-mediated apoptosis in JB6 cells. Molecular carcinogenesis, 2003, Volume: 37, Issue:3 Topics: Animals; Antineoplastic Agents; Apoptosis; Benzothiazoles; Blotting, Western; Cells, Cultured; Doxorubicin; Gene Expression Regulation; Genes, Dominant; JNK Mitogen-Activated Protein Kinases; Mice; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Precipitin Tests; Signal Transduction; Skin; Thiazoles; Toluene; Transcriptional Activation; Tumor Suppressor Protein p53; Ultraviolet Rays	2003
Inhibition of p53, p21 and Bax by pifithrin-alpha does not affect UV induced apoptotic response in CS-B cells. DNA repair, 2003, Aug-12, Volume: 2, Issue:8 Topics: Apoptosis; bcl-2-Associated X Protein; Benzothiazoles; Cells, Cultured; Cockayne Syndrome; Electrophoresis, Polyacrylamide Gel; Fluorescent Antibody Technique; Humans; Immunoblotting; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; rho GTP-Binding Proteins; Thiazoles; Toluene; Transcriptional Activation; Tumor Suppressor Protein p53; Ultraviolet Rays	2003
Involvement of p53 in specific anti-neuroectodermal tumor activity of aloe-emodin. International journal of cancer, 2003, Oct-10, Volume: 106, Issue:6 Topics: Anthraquinones; Apoptosis; Benzothiazoles; Blotting, Western; Caspases; Cell Cycle; Child, Preschool; Cytochromes c; DNA Primers; DNA Topoisomerases, Type II; DNA, Neoplasm; Emodin; Enzyme Inhibitors; Gene Expression Regulation, Neoplastic; Genes, bcl-2; Humans; Male; Microscopy, Immunoelectron; Mitochondria; Mutation; Neuroectodermal Tumors; Poly(ADP-ribose) Polymerases; Protein Transport; Reverse Transcriptase Polymerase Chain Reaction; Thiazoles; Toluene; Tumor Cells, Cultured; Tumor Suppressor Protein p53	2003
The p53-inhibitor pifithrin-alpha inhibits firefly luciferase activity in vivo and in vitro. BMC molecular biology, 2003, Sep-11, Volume: 4 Topics: Animals; Benzothiazoles; Cell Line; Cells, Cultured; Chloramphenicol O-Acetyltransferase; Coleoptera; Genes, Reporter; Humans; Luciferases; Plasmids; Thiazoles; Toluene; Transcription, Genetic; Tumor Suppressor Protein p53	2003
Reciprocal inhibition of p53 and nuclear factor-kappaB transcriptional activities determines cell survival or death in neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2003, Sep-17, Volume: 23, Issue:24 Topics: Acetyltransferases; Animals; Benzothiazoles; Brain Ischemia; Cell Cycle Proteins; Cell Death; Cell Hypoxia; Cell Survival; Cells, Cultured; Dose-Response Relationship, Drug; Female; Genes, Reporter; Glucose; Histone Acetyltransferases; Homocysteine; Male; Mice; Mice, Transgenic; Neurons; Neuroprotective Agents; NF-kappa B; p300-CBP Transcription Factors; Rats; Rats, Sprague-Dawley; Rats, Wistar; Signal Transduction; Stress, Physiological; Thiazoles; Toluene; Transcription Factors; Transcription, Genetic; Tumor Suppressor Protein p53	2003
p53 down-regulation: a new molecular mechanism involved in ischaemic preconditioning. FEBS letters, 2003, Dec-04, Volume: 555, Issue:2 Topics: Androstadienes; Animals; Benzothiazoles; Blotting, Northern; Down-Regulation; Enzyme Inhibitors; Ischemic Preconditioning, Myocardial; Male; Myocardial Infarction; Myocardial Ischemia; Myocardial Reperfusion; Nuclear Proteins; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Precipitin Tests; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-mdm2; Rats; Rats, Sprague-Dawley; Thiazoles; Toluene; Tumor Suppressor Protein p53; Wortmannin	2003
Oxidative stress induces p53-mediated apoptosis in glia: p53 transcription-independent way to die. Journal of neuroscience research, 2004, Jan-01, Volume: 75, Issue:1 Topics: Amino Acid Chloromethyl Ketones; Animals; Apoptosis; Astrocytes; Benzothiazoles; Blotting, Northern; Cell Survival; Cells, Cultured; Cytochromes c; Embryo, Mammalian; Fluorescent Antibody Technique; Genes, bcl-2; Hydrogen Peroxide; Microscopy, Confocal; Mitochondria; Models, Biological; Neuroprotective Agents; Nuclear Proteins; Nucleosomes; Oxidants; Oxidative Stress; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-mdm2; Rats; Recovery of Function; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Thiazoles; Time Factors; Toluene; Tumor Suppressor Protein p53	2004
p53-mediated mitochondrial dysfunction by proteasome inhibition in dopaminergic SH-SY5Y cells. Neuroscience letters, 2004, Jan-16, Volume: 354, Issue:3 Topics: bcl-2-Associated X Protein; Benzimidazoles; Benzothiazoles; Blotting, Western; Carbocyanines; Cell Death; Cell Line, Tumor; Cell Survival; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Dopamine; Dose-Response Relationship, Drug; Drug Interactions; Fluorescent Antibody Technique; Humans; Leupeptins; Membrane Potentials; Mitochondria; Multienzyme Complexes; Neuroblastoma; Proteasome Endopeptidase Complex; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Thiazoles; Time Factors; Toluene; Tumor Suppressor Protein p53	2004
Pifithrin-alpha protects against doxorubicin-induced apoptosis and acute cardiotoxicity in mice. American journal of physiology. Heart and circulatory physiology, 2004, Volume: 286, Issue:3 Topics: Acute Disease; Animals; Antibiotics, Antineoplastic; Apoptosis; Benzothiazoles; Cell Line, Tumor; Creatine Kinase; Doxorubicin; Gene Expression; Heart; Heart Diseases; Mice; Mice, Inbred ICR; Myocardium; Thiazoles; Toluene; Tumor Suppressor Protein p53	2004
Apoptotic mitochondrial dysfunction induced by benzo(a)pyrene in liver epithelial cells: role of p53 and pHi changes. Annals of the New York Academy of Sciences, 2003, Volume: 1010 Topics: Animals; Apoptosis; Benzo(a)pyrene; Benzothiazoles; Bongkrekic Acid; Cell Line; Epithelial Cells; Guanidines; Hydrogen-Ion Concentration; Liver; Mitochondria; Rats; Sulfones; Thiazoles; Toluene; Tumor Suppressor Protein p53	2003
Dual effect of p53 on radiation sensitivity in vivo: p53 promotes hematopoietic injury, but protects from gastro-intestinal syndrome in mice. Oncogene, 2004, Apr-22, Volume: 23, Issue:19 Topics: Animals; Apoptosis; Benzothiazoles; Digestive System; Hematopoiesis; Mice; Mice, Inbred C57BL; Radiation Tolerance; Thiazoles; Toluene; Tumor Suppressor Protein p53	2004
The role of p53-induced apoptosis in cerebral ischemia: effects of the p53 inhibitor pifithrin alpha. Experimental neurology, 2004, Volume: 187, Issue:2 Topics: Animals; Apoptosis; Benzothiazoles; Blotting, Western; Brain; Brain Ischemia; Cell Count; Disability Evaluation; Disease Models, Animal; Dose-Response Relationship, Drug; Immunohistochemistry; Male; Motor Activity; Neuroprotective Agents; Rats; Rats, Sprague-Dawley; Thiazoles; Time Factors; Toluene; Tumor Suppressor Protein p53	2004
Pifithrin-alpha inhibits p53 signaling after interaction of the tumor suppressor protein with hsp90 and its nuclear translocation. The Journal of biological chemistry, 2004, Jul-16, Volume: 279, Issue:29 Topics: Active Transport, Cell Nucleus; Animals; Benzothiazoles; Cell Line; Cell Nucleus; Chloramphenicol O-Acetyltransferase; Cyclin-Dependent Kinase Inhibitor p21; Cyclins; Dexamethasone; Dose-Response Relationship, Drug; HeLa Cells; HSP70 Heat-Shock Proteins; HSP90 Heat-Shock Proteins; Humans; Immunophilins; Mice; Protein Binding; Signal Transduction; Thiazoles; Time Factors; Toluene; Transcription, Genetic; Tumor Suppressor Protein p53; Tumor Suppressor Proteins	2004
Improvement of rat liver graft quality by pifithrin-alpha-mediated inhibition of hepatocyte necrapoptosis. Hepatology (Baltimore, Md.), 2004, Volume: 39, Issue:6 Topics: Animals; Apoptosis; Benzothiazoles; Caspase 3; Caspases; Female; Hepatocytes; Immunohistochemistry; Liver; Liver Transplantation; Male; Necrosis; Rats; Rats, Sprague-Dawley; Thiazoles; Toluene	2004
Selenite-induced p53 Ser-15 phosphorylation and caspase-mediated apoptosis in LNCaP human prostate cancer cells. Molecular cancer therapeutics, 2004, Volume: 3, Issue:7 Topics: Amino Acid Chloromethyl Ketones; Apoptosis; Benzothiazoles; Caspase Inhibitors; Caspases; Cell Line, Tumor; Enzyme Activation; Humans; Male; Phosphorylation; Poly(ADP-ribose) Polymerases; Prostatic Neoplasms; Serine; Sodium Selenite; Thiazoles; Toluene; Tumor Suppressor Protein p53	2004
Role of p53 in cisplatin-induced tubular cell apoptosis: dependence on p53 transcriptional activity. American journal of physiology. Renal physiology, 2004, Volume: 287, Issue:6 Topics: Amino Acid Chloromethyl Ketones; Animals; Apoptosis; Benzothiazoles; Caspase Inhibitors; Caspases; Cell Line; Cisplatin; Enzyme Inhibitors; Genes, p53; Kidney Tubules, Proximal; Mutation; Phosphorylation; Proto-Oncogene Proteins c-bcl-2; Rats; Thiazoles; Toluene; Transcription, Genetic; Transfection; Tumor Suppressor Protein p53	2004
Calcitriol-induced prostate-derived factor: autocrine control of prostate cancer cell growth. International journal of cancer, 2004, Dec-20, Volume: 112, Issue:6 Topics: Antineoplastic Agents; Benzothiazoles; Bone Morphogenetic Proteins; Calcitriol; Calcium Channel Agonists; Cell Line, Tumor; Cell Proliferation; Dactinomycin; Dihydrotestosterone; DNA, Complementary; DNA, Neoplasm; Dose-Response Relationship, Drug; Gene Expression Regulation, Neoplastic; Growth Differentiation Factor 15; Humans; Male; Membrane Proteins; Prostatic Neoplasms; Recombinant Proteins; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; RNA, Neoplasm; Thiazoles; Toluene; Vanadates	2004
Survivin and p53 modulate quercetin-induced cell growth inhibition and apoptosis in human lung carcinoma cells. The Journal of biological chemistry, 2004, Dec-31, Volume: 279, Issue:53 Topics: Apoptosis; Benzothiazoles; Blotting, Western; Carcinoma; Cell Cycle; Cell Cycle Proteins; Cell Line, Tumor; Cell Proliferation; Cyclin B; Cyclin B1; Cyclin-Dependent Kinase Inhibitor p21; DNA; Fluorescent Antibody Technique, Indirect; G2 Phase; Humans; Inhibitor of Apoptosis Proteins; Lung Neoplasms; Male; Microscopy, Phase-Contrast; Microtubule-Associated Proteins; Middle Aged; Mitosis; Models, Biological; Neoplasm Proteins; Oligonucleotides, Antisense; Phosphorylation; Protein Transport; Quercetin; RNA, Small Interfering; Survivin; Thiazoles; Threonine; Time Factors; Toluene; Transfection; Tumor Suppressor Protein p53	2004
Dynamin-2 regulates oxidized low-density lipoprotein-induced apoptosis of vascular smooth muscle cell. Circulation, 2004, Nov-23, Volume: 110, Issue:21 Topics: Animals; Apolipoproteins E; Apoptosis; Benzothiazoles; Coronary Vessels; Dynamin II; Endocytosis; Humans; Hyperlipoproteinemia Type II; Lipoproteins, LDL; Mice; Mice, Inbred C57BL; Mice, Knockout; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Receptors, LDL; Receptors, Oxidized LDL; Scavenger Receptors, Class E; Signal Transduction; Thiazoles; Toluene; Transfection; Tumor Suppressor Protein p53	2004
5-Aza-cytidine is a potent inhibitor of DNA methyltransferase 3a and induces apoptosis in HCT-116 colon cancer cells via Gadd45- and p53-dependent mechanisms. The Journal of pharmacology and experimental therapeutics, 2005, Volume: 312, Issue:2 Topics: Annexin A5; Apoptosis; Azacitidine; Benzothiazoles; Blotting, Western; Cell Cycle Proteins; Cell Line, Tumor; Cell Proliferation; Cyclin-Dependent Kinase Inhibitor p21; DNA (Cytosine-5-)-Methyltransferases; DNA Methyltransferase 3A; DNA, Complementary; DNA, Neoplasm; Down-Regulation; Enzyme Inhibitors; Flow Cytometry; G2 Phase; GADD45 Proteins; Humans; In Situ Nick-End Labeling; Intracellular Signaling Peptides and Proteins; Methylation; Proteins; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Thiazoles; Toluene; Tumor Suppressor Protein p53	2005
Deregulation of cell proliferation by polycyclic aromatic hydrocarbons in human breast carcinoma MCF-7 cells reflects both genotoxic and nongenotoxic events. Toxicological sciences : an official journal of the Society of Toxicology, 2005, Volume: 83, Issue:2 Topics: Benz(a)Anthracenes; Benzo(a)pyrene; Benzothiazoles; Breast Neoplasms; Bromodeoxyuridine; Carcinogens; Carcinoma; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Cell Survival; DNA Replication; Dose-Response Relationship, Drug; Drug Interactions; Epigenesis, Genetic; Estradiol; Estrogen Antagonists; Female; Fulvestrant; Humans; Receptors, Estrogen; Thiazoles; Toluene; Tumor Suppressor Protein p53	2005
Selective increase of dATP pools upon activation of deoxycytidine kinase in lymphocytes: implications in apoptosis. Nucleosides, nucleotides & nucleic acids, 2004, Volume: 23, Issue:8-9 Topics: Adenosine Triphosphate; Antineoplastic Agents; Apoptosis; Benzothiazoles; Cells, Cultured; Cladribine; Cytochromes c; Deoxycytidine Kinase; DNA Repair; Dose-Response Relationship, Drug; Enzyme Activation; Humans; Lymphocytes; Models, Biological; Palatine Tonsil; Phosphotransferases (Alcohol Group Acceptor); Thiazoles; Toluene; Tumor Suppressor Protein p53	2004
Inhibition of P53-related apoptosis had no effect on PrP(Sc) accumulation and prion disease incubation time. Neurobiology of disease, 2005, Volume: 18, Issue:2 Topics: Animals; Apoptosis; Benzothiazoles; Brain; Caspase 3; Caspases; Cell Line; Cricetinae; Disease Models, Animal; Disease Progression; Mesocricetus; Mice; Neurons; PrPSc Proteins; Scrapie; Thiazoles; Toluene; Treatment Outcome; Tumor Suppressor Protein p53	2005
Role of p53 and apoptosis in cerebral vasospasm after experimental subarachnoid hemorrhage. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2005, Volume: 25, Issue:5 Topics: Animals; Apoptosis; Basilar Artery; Benzothiazoles; Blotting, Western; Brain; Cerebral Angiography; Disease Models, Animal; Dogs; Endothelial Cells; Female; Immunohistochemistry; In Situ Nick-End Labeling; Male; Myocytes, Smooth Muscle; Subarachnoid Hemorrhage; Thiazoles; Toluene; Tumor Suppressor Protein p53; Vasospasm, Intracranial	2005
Novel cyclized Pifithrin-alpha p53 inactivators: synthesis and biological studies. Bioorganic & medicinal chemistry letters, 2005, Mar-15, Volume: 15, Issue:6 Topics: Animals; Benzothiazoles; Cerebral Cortex; Drug Stability; Etoposide; Mice; Models, Chemical; Molecular Structure; Neurons; Structure-Activity Relationship; Thiazoles; Toluene; Tumor Suppressor Protein p53	2005
Quinolinium salt as a potent inhibitor of lymphocyte apoptosis. Bioorganic & medicinal chemistry letters, 2005, Apr-01, Volume: 15, Issue:7 Topics: Antineoplastic Agents; Apoptosis; Benzothiazoles; Glucocorticoids; Humans; Lymphocytes; Quinolinium Compounds; Salts; Structure-Activity Relationship; Thiazoles; Toluene; Tumor Cells, Cultured	2005
Sensitization of cervical cancer cell lines to low-dose radiation by retinoic acid does not require functional p53. Gynecologic oncology, 2005, Volume: 97, Issue:1 Topics: Alitretinoin; Benzothiazoles; Cell Differentiation; Cell Line, Tumor; Cell Proliferation; Combined Modality Therapy; DNA Damage; Dose-Response Relationship, Radiation; Female; Genes, fos; Humans; Radiation-Sensitizing Agents; Thiazoles; Toluene; Transfection; Tretinoin; Tumor Suppressor Protein p53; Uterine Cervical Neoplasms	2005
Pharmaceutical-mediated inactivation of p53 sensitizes U87MG glioma cells to BCNU and temozolomide. International journal of cancer, 2005, Aug-20, Volume: 116, Issue:2 Topics: Antineoplastic Agents, Alkylating; Benzothiazoles; Brain Neoplasms; Carmustine; Dacarbazine; DNA Damage; Drug Interactions; Glioma; Humans; Temozolomide; Thiazoles; Toluene; Tumor Cells, Cultured; Tumor Suppressor Protein p53	2005
The p53 inhibitor pifithrin-alpha is a potent agonist of the aryl hydrocarbon receptor. The Journal of pharmacology and experimental therapeutics, 2005, Volume: 314, Issue:2 Topics: Apoptosis; Benzothiazoles; Blotting, Western; Cells, Cultured; Cytochrome P-450 CYP1A1; DNA; Electrophoretic Mobility Shift Assay; Humans; Ligands; Oligonucleotides; Plasmids; Polychlorinated Dibenzodioxins; Promoter Regions, Genetic; Receptors, Aryl Hydrocarbon; Reverse Transcriptase Polymerase Chain Reaction; Thiazoles; Toluene; Transfection; Tumor Suppressor Protein p53	2005
p53-dependent caspase-2 activation in mitochondrial release of apoptosis-inducing factor and its role in renal tubular epithelial cell injury. The Journal of biological chemistry, 2005, Sep-02, Volume: 280, Issue:35 Topics: Amino Acid Chloromethyl Ketones; Animals; Antineoplastic Agents; Apoptosis Inducing Factor; Benzothiazoles; Carrier Proteins; Caspase 2; Caspase 3; Caspase Inhibitors; Caspases; Cell Nucleus; Cisplatin; Cysteine Proteinase Inhibitors; Death Domain Receptor Signaling Adaptor Proteins; Enzyme Activation; Epithelial Cells; Flavoproteins; Kidney Tubules; Membrane Proteins; Mice; Mice, Knockout; Mitochondria; RNA, Small Interfering; Thiazoles; Toluene; Tumor Suppressor Protein p53	2005
Loss of tumor suppressor p53 decreases PTEN expression and enhances signaling pathways leading to activation of activator protein 1 and nuclear factor kappaB induced by UV radiation. Cancer research, 2005, Aug-01, Volume: 65, Issue:15 Topics: Animals; Benzothiazoles; Cell Line; Down-Regulation; Epidermis; JNK Mitogen-Activated Protein Kinases; MAP Kinase Signaling System; Mice; NF-kappa B; p38 Mitogen-Activated Protein Kinases; Phosphoric Monoester Hydrolases; Phosphorylation; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; PTEN Phosphohydrolase; Ribosomal Protein S6 Kinases, 70-kDa; RNA, Small Interfering; Thiazoles; Toluene; Transcription Factor AP-1; Transfection; Tumor Suppressor Protein p53; Tumor Suppressor Proteins; Ultraviolet Rays	2005
Pifithrin-alpha induced p53 inhibition does not affect liver regeneration after partial hepatectomy in mice. Journal of hepatology, 2005, Volume: 43, Issue:5 Topics: Animals; Apoptosis; Benzothiazoles; Cyclin-Dependent Kinase Inhibitor p21; Hepatectomy; Hepatocytes; In Situ Nick-End Labeling; Liver Regeneration; Male; Mice; Mice, Inbred C57BL; Organ Size; Proliferating Cell Nuclear Antigen; Thiazoles; Toluene; Tumor Suppressor Protein p53	2005
An evaluation of the ability of pifithrin-alpha and -beta to inhibit p53 function in two wild-type p53 human tumor cell lines. Molecular cancer therapeutics, 2005, Volume: 4, Issue:9 Topics: Animals; Benzothiazoles; Cell Cycle; Cell Line, Tumor; Cells, Cultured; Colonic Neoplasms; Female; Fibroblasts; Humans; Mice; Mitogen-Activated Protein Kinases; NIH 3T3 Cells; Ovarian Neoplasms; Phosphorylation; Radiation Tolerance; Radiation, Ionizing; Thiazoles; Toluene; Tumor Suppressor Protein p53	2005
Inhibitors of apoptosis in lymphocytes: synthesis and biological evaluation of compounds related to pifithrin-alpha. Journal of medicinal chemistry, 2005, Oct-06, Volume: 48, Issue:20 Topics: Animals; Apoptosis; Benzimidazoles; Benzothiazoles; Dexamethasone; Gamma Rays; Imidazoles; In Vitro Techniques; Lymphocytes; Mice; Mice, Inbred C57BL; Pyrrolidines; Structure-Activity Relationship; Thiazoles; Thymus Gland; Toluene; Tumor Suppressor Protein p53	2005
DNA damage and nonhomologous end joining in excitotoxicity: neuroprotective role of DNA-PKcs in kainic acid-induced seizures. Hippocampus, 2005, Volume: 15, Issue:8 Topics: Animals; Benzothiazoles; Cell Death; Cells, Cultured; DNA Damage; DNA Repair; DNA-Activated Protein Kinase; DNA-Binding Proteins; Entorhinal Cortex; Excitatory Amino Acid Agonists; Heterozygote; Hippocampus; Immunohistochemistry; In Situ Nick-End Labeling; Kainic Acid; Membrane Potentials; Mice; Mice, Inbred C57BL; Mice, Neurologic Mutants; Mitochondria; Nerve Degeneration; Neurons; Nuclear Proteins; Seizures; Thiazoles; Toluene; Tumor Suppressor Protein p53	2005
Potent inhibition of carcinogen-bioactivating cytochrome P450 1B1 by the p53 inhibitor pifithrin alpha. Carcinogenesis, 2006, Volume: 27, Issue:3 Topics: Apoptosis; Aryl Hydrocarbon Hydroxylases; Benzo(a)pyrene; Benzothiazoles; Breast Neoplasms; Carcinogens; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP1B1; Humans; Leukemia; Macrophages; Microsomes, Liver; Protein Isoforms; Thiazoles; Toluene; Tumor Cells, Cultured; Tumor Suppressor Protein p53	2006
Regulation of p53 and suppression of apoptosis by the soluble guanylyl cyclase/cGMP pathway in human ovarian cancer cells. Oncogene, 2006, Apr-06, Volume: 25, Issue:15 Topics: Adenoviridae; Apoptosis; Atrial Natriuretic Factor; bcl-2-Associated X Protein; Benzothiazoles; Caspase 3; Caspases; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Cyclin-Dependent Kinase Inhibitor p21; Enzyme Activation; Enzyme Inhibitors; Female; Gene Expression Regulation, Neoplastic; Guanylate Cyclase; Half-Life; Humans; Mutation; Ovarian Neoplasms; Oxadiazoles; Phosphorylation; Proto-Oncogene Proteins c-mdm2; Quinoxalines; RNA, Small Interfering; Serine; Signal Transduction; Thiazoles; Toluene; Tumor Cells, Cultured; Tumor Suppressor Protein p53; X-Linked Inhibitor of Apoptosis Protein	2006
P53 mediates amosite asbestos-induced alveolar epithelial cell mitochondria-regulated apoptosis. American journal of respiratory cell and molecular biology, 2006, Volume: 34, Issue:4 Topics: Animals; Apoptosis; Asbestos, Amosite; Asbestosis; bcl-2-Associated X Protein; Benzothiazoles; Caspase 9; Caspases; Cell Line; Enzyme Activation; Epithelial Cells; Free Radical Scavengers; Humans; Iron Chelating Agents; Lung; Membrane Potentials; Mitochondrial Membranes; Oncogene Proteins, Viral; Phytic Acid; Promoter Regions, Genetic; Protein Transport; Pulmonary Alveoli; Rats; Reactive Oxygen Species; Repressor Proteins; Thiazoles; Toluene; Tumor Suppressor Protein p53	2006
Insulin-like growth factor-1 prevents Abeta[25-35]/(H2O2)- induced apoptosis in lymphocytes by reciprocal NF-kappaB activation and p53 inhibition via PI3K-dependent pathway. Growth factors (Chur, Switzerland), 2006, Volume: 24, Issue:1 Topics: Adult; Amyloid beta-Peptides; Apoptosis; Benzothiazoles; Chromones; Humans; Hydrogen Peroxide; In Vitro Techniques; Insulin-Like Growth Factor I; Lymphocytes; Male; Mitochondrial Membranes; Morpholines; NF-kappa B; Peptide Fragments; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Proline; Thiazoles; Thiocarbamates; Toluene; Tumor Suppressor Protein p53; Up-Regulation	2006
Histone deacetylase inhibitor-mediated radiosensitization of human cancer cells: class differences and the potential influence of p53. Clinical cancer research : an official journal of the American Association for Cancer Research, 2006, Feb-01, Volume: 12, Issue:3 Pt 1 Topics: Amides; Benzothiazoles; Biphenyl Compounds; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Dose-Response Relationship, Radiation; Enzyme Inhibitors; Fatty Acids, Unsaturated; Gene Expression Regulation; HeLa Cells; Histone Deacetylase Inhibitors; Histone Deacetylases; Humans; Hydroxamic Acids; Naphthalenes; Pyrones; Radiation-Sensitizing Agents; Thiazoles; Toluene; Tumor Cells, Cultured; Tumor Suppressor Protein p53	2006
Modulation of p53 transcriptional activity by PRIMA-1 and Pifithrin-alpha on staurosporine-induced apoptosis of wild-type and mutated p53 epithelial cells. Apoptosis : an international journal on programmed cell death, 2006, Volume: 11, Issue:5 Topics: Apoptosis; bcl-2-Associated X Protein; Benzothiazoles; Cell Culture Techniques; Cell Line, Transformed; Cell Line, Tumor; Cell Transformation, Viral; DNA, Neoplasm; Drug Combinations; Enzyme Inhibitors; Epithelial Cells; Female; HeLa Cells; Humans; Membrane Potentials; Membrane Proteins; Mitochondria; Mutation; Nerve Tissue Proteins; Papillomaviridae; Staurosporine; Thiazoles; Toluene; Transcription, Genetic; Tumor Suppressor Protein p53	2006
[Expression of p53 in neonatal mice following hypoxia-ischemia and effects of its inhibitor on neonatal brain injury]. Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics, 2006, Volume: 8, Issue:2 Topics: Animals; Animals, Newborn; Benzothiazoles; Brain; Dose-Response Relationship, Drug; Female; Hypoxia-Ischemia, Brain; Immunohistochemistry; Male; Mice; Mice, Inbred C57BL; Thiazoles; Toluene; Tumor Suppressor Protein p53	2006
Evidence for p53-like-mediated stress responses in green algae. FEBS letters, 2006, May-29, Volume: 580, Issue:13 Topics: Amino Acid Sequence; Animals; Benzothiazoles; Chlamydomonas reinhardtii; Genes, p53; Molecular Sequence Data; Thiazoles; Toluene; Tumor Suppressor Protein p53; Volvox	2006
Multiple actions of pifithrin-alpha on doxorubicin-induced apoptosis in rat myoblastic H9c2 cells. American journal of physiology. Heart and circulatory physiology, 2006, Volume: 290, Issue:6 Topics: Animals; Antibiotics, Antineoplastic; Apoptosis; Benzothiazoles; Blotting, Western; Caspases; Cell Line, Tumor; Cytochromes c; Doxorubicin; Electrophoretic Mobility Shift Assay; Energy Metabolism; Enzyme Activation; Enzyme-Linked Immunosorbent Assay; fas Receptor; Genes, p53; Mitogen-Activated Protein Kinases; Myocardium; Neoplasms, Muscle Tissue; Oxidative Stress; Phosphorylation; Poly(ADP-ribose) Polymerases; Rats; Thiazoles; Toluene	2006
Vasospasm and p53-induced apoptosis in an experimental model of subarachnoid hemorrhage. Stroke, 2006, Volume: 37, Issue:7 Topics: Animals; Apoptosis Regulatory Proteins; Basilar Artery; Benzothiazoles; Blood-Brain Barrier; Blotting, Western; Body Water; Brain; Brain Chemistry; Cerebrovascular Circulation; Male; Models, Animal; Nerve Tissue Proteins; Permeability; Random Allocation; Rats; Rats, Sprague-Dawley; Single-Blind Method; Subarachnoid Hemorrhage; Thiazoles; Toluene; Tumor Suppressor Protein p53; Vasospasm, Intracranial	2006
Imino-tetrahydro-benzothiazole derivatives as p53 inhibitors: discovery of a highly potent in vivo inhibitor and its action mechanism. Journal of medicinal chemistry, 2006, Jun-15, Volume: 49, Issue:12 Topics: Administration, Topical; Animals; Antineoplastic Agents; Apoptosis; Axotomy; Benzothiazoles; Cells, Cultured; Cyclin-Dependent Kinase Inhibitor p21; Drug Design; Drug Stability; Etoposide; Imines; Male; Mice; Neocortex; Neuroprotective Agents; Optic Nerve; Phosphorylation; Prodrugs; Rats; Rats, Wistar; Retinal Ganglion Cells; Thiazoles; Toluene; Tumor Suppressor Protein p53; Vitreous Body	2006
TEL/ETV6 induces apoptosis in 32D cells through p53-dependent pathways. Biochemical and biophysical research communications, 2006, Aug-25, Volume: 347, Issue:2 Topics: Animals; Apoptosis; Benzothiazoles; Blotting, Northern; Blotting, Western; Cell Line; Cell Proliferation; ETS Translocation Variant 6 Protein; Granulocyte Colony-Stimulating Factor; Humans; Interleukin-3; Membrane Potentials; Mitochondrial Membranes; Mutation; Proto-Oncogene Proteins c-bcl-2; Proto-Oncogene Proteins c-ets; Repressor Proteins; RNA, Messenger; Signal Transduction; Thiazoles; Toluene; Transcription, Genetic; Transfection; Tumor Suppressor Protein p53	2006
Ionizing radiation suppresses FAP-1 mRNA level in A549 cells via p53 activation. FEBS letters, 2006, Aug-07, Volume: 580, Issue:18 Topics: Benzothiazoles; Cell Line, Tumor; Down-Regulation; fas Receptor; Humans; Protein Phosphatase 1; Protein Tyrosine Phosphatase, Non-Receptor Type 13; Protein Tyrosine Phosphatases; Radiation, Ionizing; RNA, Messenger; Thiazoles; Toluene; Transcription, Genetic; Tumor Suppressor Protein p53	2006
Small-molecule inhibitor of p53 binding to mitochondria protects mice from gamma radiation. Nature chemical biology, 2006, Volume: 2, Issue:9 Topics: Animals; Apoptosis; Apoptosis Regulatory Proteins; Benzothiazoles; Cell Line; Dexamethasone; Gamma Rays; Humans; Male; Mice; Mice, Inbred C57BL; Mitochondria; Protein Binding; Protein Transport; Radiation Injuries, Experimental; Radiation-Protective Agents; Thiazoles; Thymus Gland; Toluene; Transcriptional Activation; Tumor Suppressor Protein p53; Ultraviolet Rays	2006
Inhibition of p53 response in tumor stroma improves efficacy of anticancer treatment by increasing antiangiogenic effects of chemotherapy and radiotherapy in mice. Cancer research, 2006, Oct-01, Volume: 66, Issue:19 Topics: Angiogenesis Inhibitors; Animals; Antineoplastic Agents, Alkylating; Benzothiazoles; Carcinoma, Lewis Lung; Cell Line, Transformed; Cyclophosphamide; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Endothelial Cells; Fibroblasts; Imidazoles; Mice; Mice, Inbred C57BL; NIH 3T3 Cells; Protein Conformation; Radiation-Sensitizing Agents; Rats; Stromal Cells; Thiazoles; Toluene; Transduction, Genetic; Tumor Suppressor Protein p53	2006
Optimized Approaches for Generation of Integration-free iPSCs from Human Urine-Derived Cells with Small Molecules and Autologous Feeder. Stem cell reports, 2016, 05-10, Volume: 6, Issue:5 Topics: Benzamides; Benzothiazoles; Cell Differentiation; Cell Proliferation; Cellular Reprogramming; Diphenylamine; Humans; Induced Pluripotent Stem Cells; Pyrazoles; Pyridines; Pyrimidines; Thiazoles; Thiosemicarbazones; Toluene; Urine	2016