pidotimod has been researched along with thiazoles in 54 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 50 (92.59) | 18.2507 |
| 2000's | 4 (7.41) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Chisari, G; Condorelli, F; di Marco, R; di Mauro, M; Girardello, R; Meroni, PL; Nicoletti, F; Speciale, AM; Uslenghi, C | 1 |
| Coppi, G; D'Adamio, L; Migliorati, G; Nicoletti, I; Riccardi, C | 1 |
| Coppi, G; D'Adamio, F; Migliorati, G; Nicoletti, I; Pagliacci, C; Riccardi, C | 1 |
| Capsoni, F; Girardello, R; Minonzio, F; Ongari, AM; Zanussi, C | 1 |
| Forno, B; Girardello, R; Marinelli, L; Pollono, AM; Pugliese, A; Uslenghi, C | 1 |
| Coppi, G; Falcone, A; Manzardo, S | 2 |
| Auteri, A; Bova, G; Bruni, F; Di Renzo, M; Pasqui, AL; Saletti, M | 1 |
| Alfano, S; Biolchini, A; Careddu, P; Zavattini, G | 1 |
| Barchielli, M; Coppi, G | 2 |
| Annoni, G; Arosio, B; Cullurà, D; Gagliano, N; Santambrogio, D; Uslenghi, C | 1 |
| Maillard, F | 1 |
| Bocchiola, G; Magni, A; Signorelli, G | 1 |
| Anders, U; Bocchiola, G; Crimella, T; Orlandi, R; Stradi, R | 1 |
| Coppi, G; Manzardo, S | 1 |
| Migliorati, G; Nicoletti, I; Riccardi, C | 1 |
| Basilico, N; Cocuzza, C; Malabarba, MG; Mattina, R; Sala, G; Taramelli, D | 1 |
| Colangelo, D; Dianzani, C; Guidotto, S; Tonso, E; Viano, I | 1 |
| Barbera, N; Bernardini, R; Cantarella, G; Chiarenza, A; Iurato, MP; Lempereur, L; Scapagnini, G; Scapagnini, U | 1 |
| Coppi, G; Falcone, A; Ieva, G; Manzardo, S; Pinzetta, A | 1 |
| Amico-Roxas, M; Bertè, F; Bussi, R; Coppi, G; Gnemi, P; Harling, RJ; Mailland, F; Manzardo, S; Massey, JE; Spencer-Briggs, DJ | 1 |
| Adams, K; Allen, JA; Brooker, PC; Coppi, G; Henderson, L; Jones, E; Mailland, F; Proudlock, RJ | 1 |
| Coppi, G; Silingardi, S | 1 |
| Coppi, G; Mailland, F; Silingardi, S | 1 |
| Biffi, M; Coppi, G; Mailland, F; Silingardi, S; Spotti, D | 1 |
| Caravaggi, M; Crema, A; Crema, F; D'Angelo, L; De Ponti, F | 1 |
| Benetti, GP; Bombelli, G; Fugazza, L; Illeni, MT; La Vecchia, G; Montalto, F; Stramba Badiale, M; Uslenghi, C | 1 |
| Caramia, G; Carnelli, V; Cera, R; Clemente, E; Corsini, A; Mei, V; Solli, R; Venturoli, V | 1 |
| Careddu, P; Corsini, A; Mei, V; Venturoli, V | 1 |
| Caramia, G; Carnelli, V; Cera, R; Clemente, E; Corsini, A; Mei, V; Ruffini, E; Solli, R; Venturoli, V | 1 |
| Cirianni, C; Dolcetti, A; Fugazza, L; Moreo, G; Orlandi, O; Piacenza, G; Pozzi, E; Rampulla, C; Scarpazza, G | 1 |
| Bariffi, F; Bertoli, L; Bisetti, A; Cardani, A; Catena, E; Ciappi, G; Grassi, V; Rocco, V; Scarpazza, G; Vaccaro, L | 1 |
| Benetti, GP; Bombelli, G; Illeni, MT; Lavecchia, G; Passera, A; Uslenghi, C | 1 |
| Careddu, P | 1 |
| Calearo, C; Conticello, S; Passali, D | 1 |
| Ciaccia, A | 1 |
| De Campora, E; De Vita, C; Esposito, S; Galletti, C; Incutti, V; Mallardi, V; Motta, G; Motta, S; Pucci, V; Salonna, F | 1 |
| Burgio, GR; De Benedetti, F; Marseglia, GL; Masarone, M; Nespoli, L; Ottolenghi, A; Pagliano, L; Serra, U; Severi, F | 1 |
| Broccali, GP; Coppi, G; Dal Bo, L; Silingardi, S | 1 |
| Coppi, G; Delfino, D; Maggioni, A; Migliorati, G; Nicoletti, I; Riccardi, C | 1 |
| Campa, M; Girardello, R; Lupetti, A; Marelli, P; Senesi, S; Uslenghi, C | 1 |
| Caloro, D; Dammacco, F; Di Stefano, R; Ranieri, G; Vacca, A | 1 |
| Eftimiadi, C; Oddera, S; Rossi, GA; Sacco, O; Silvestri, M | 1 |
| Barcellini, W; Borghi, MO; Carbonelli, V; Del Papa, N; Fain, C; Gambini, D; La Rosa, L; Meroni, PL; Minonzio, F; Piona, A | 1 |
| Auteri, A; Bova, G; Bruni, F; Di Renzo, M; Gotti, G; Pasqui, AL; Saletti, M | 1 |
| Annoni, G; Arosio, B; Gagliano, N; Santambrogio, D | 1 |
| Auteri, A; Bova, G; Bruni, F; Chiarion, C; Di Renzo, M; Ferrì, P; Girardello, R; Pasqui, AL; Saletti, M | 1 |
| Guerra, B; Perino, A; Polatti, F; Scala, M | 1 |
| Di Mauro, M; Grillo, C; La Mantia, I; Mattina, T; Meroni, PL; Nicoletti, F; Xiang, M; Zaccone, P | 1 |
| Aivazis, V; Hatzimichail, A; Iuga-Donca, G; Papachristou, A; Valeri, R | 1 |
| Bossios, A; Gourgiotis, D; Papadopoulos, NG; Saxoni-Papageorgiou, P; Zamanis, P | 1 |
| Larcombe, J | 1 |
| Choung, SY; Du, XF; Jiang, CZ; Won, EK; Wu, CF | 1 |
1 review(s) available for pidotimod and thiazoles
| Article | Year |
|---|---|
Urinary tract infection in children.
Topics: Anti-Bacterial Agents; Child; Child, Preschool; Female; Humans; Infant; Male; Pyelonephritis; Pyrrolidonecarboxylic Acid; Secondary Prevention; Thiazoles; Thiazolidines; Urinary Tract Infections; Vesico-Ureteral Reflux | 2005 |
20 trial(s) available for pidotimod and thiazoles
| Article | Year |
|---|---|
Pidotimod in the prophylaxis of recurrent acute tonsillitis in childhood.
Topics: Acute Disease; Adolescent; Child; Child, Preschool; Double-Blind Method; Female; Humans; Male; Pyrrolidonecarboxylic Acid; Recurrence; Thiazoles; Thiazolidines; Tonsillitis | 1992 |
Pharmacokinetics and oral bioavailability of pidotimod in humans.
Topics: Administration, Oral; Adolescent; Adult; Biological Availability; Cross-Over Studies; Double-Blind Method; Female; Half-Life; Humans; Immunologic Factors; Injections, Intramuscular; Male; Middle Aged; Protein Binding; Pyrrolidonecarboxylic Acid; Thiazoles; Thiazolidines | 1994 |
Pharmacokinetics of pidotimod in elderly volunteers and in renal failure patients.
Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Female; Half-Life; Humans; Immunologic Factors; Injections, Intravenous; Intestinal Absorption; Male; Middle Aged; Pyrrolidonecarboxylic Acid; Renal Insufficiency; Thiazoles; Thiazolidines; Urea | 1994 |
Effect of food on the bioavailability of pidotimod in healthy volunteers.
Topics: Adult; Biological Availability; Chromatography, High Pressure Liquid; Cross-Over Studies; Food-Drug Interactions; Humans; Immunologic Factors; Male; Pyrrolidonecarboxylic Acid; Spectrophotometry, Ultraviolet; Therapeutic Equivalency; Thiazoles; Thiazolidines | 1994 |
Ex vivo evaluation of pidotimod activity on cell-mediated immunity.
Topics: Adjuvants, Immunologic; Adult; Aged; Aged, 80 and over; CD3 Complex; Double-Blind Method; Female; Humans; Immunity, Cellular; Lymphocyte Count; Male; Middle Aged; Neoplasms; Phytohemagglutinins; Pyrrolidonecarboxylic Acid; Stimulation, Chemical; T-Lymphocytes; Thiazoles; Thiazolidines | 1994 |
Efficacy and safety of pidotimod in the treatment of recurrent respiratory infections in children.
Topics: Adjuvants, Immunologic; Anti-Bacterial Agents; Chemotaxis, Leukocyte; Child; Double-Blind Method; Female; Humans; Infant; Male; Phagocytosis; Pyrrolidonecarboxylic Acid; Recurrence; Respiratory Tract Infections; Thiazoles; Thiazolidines | 1994 |
Pidotimod in the treatment of recurrent respiratory infections in paediatric patients.
Topics: Bronchitis; Child; Child, Preschool; Double-Blind Method; Female; Humans; Immunologic Factors; Laryngitis; Lymphocyte Count; Male; Otitis; Pharyngitis; Pyrrolidonecarboxylic Acid; Recurrence; Respiratory Tract Infections; Rhinitis; Thiazoles; Thiazolidines; Tracheitis | 1994 |
Therapeutic efficacy and safety of pidotimod in the treatment of urinary tract infections in children.
Topics: Anti-Infective Agents, Urinary; Chemotaxis, Leukocyte; Child; Child, Preschool; Double-Blind Method; Female; Humans; Immunologic Factors; Male; Phagocytosis; Pyrrolidonecarboxylic Acid; Recurrence; Thiazoles; Thiazolidines; Urinary Tract Infections | 1994 |
Pidotimod in the treatment of patients affected by bacterial exacerbations of chronic bronchitis.
Topics: Adult; Aged; Bronchitis; Chronic Disease; Double-Blind Method; Female; Humans; Immunologic Factors; Male; Middle Aged; Pyrrolidonecarboxylic Acid; Recurrence; Respiratory Tract Infections; Skin Tests; Sputum; T-Lymphocytes, Helper-Inducer; T-Lymphocytes, Regulatory; Thiazoles; Thiazolidines | 1994 |
Evaluation of the efficacy of pidotimod in the exacerbations in patients affected with chronic bronchitis.
Topics: Adult; Aged; Aged, 80 and over; Bacterial Infections; Bronchitis; Chronic Disease; Double-Blind Method; Female; Follow-Up Studies; Humans; Immunologic Factors; Male; Middle Aged; Pyrrolidonecarboxylic Acid; Respiratory Function Tests; Thiazoles; Thiazolidines | 1994 |
Ex vivo evaluation of pidotimod activity in patients with chronic obstructive pulmonary disease.
Topics: Adjuvants, Immunologic; Adult; Aged; Aged, 80 and over; Double-Blind Method; Female; Follow-Up Studies; Granulocytes; Humans; Lung Diseases, Obstructive; Lymphocyte Activation; Lymphocytes; Macrophages; Male; Middle Aged; Pyrrolidonecarboxylic Acid; Thiazoles; Thiazolidines | 1994 |
Role of immunoactivation with pidotimod in recurrent respiratory infections in childhood.
Topics: Adjuvants, Immunologic; Adolescent; Analgesics, Non-Narcotic; Anti-Bacterial Agents; Child; Child, Preschool; Double-Blind Method; Female; Humans; Male; Pyrrolidonecarboxylic Acid; Recurrence; Respiratory Tract Infections; Risk Factors; Thiazoles; Thiazolidines; Tonsillitis | 1994 |
Pidotimod in the management of recurrent pharyngotonsillar infections in childhood.
Topics: Adjuvants, Immunologic; Adolescent; Adult; Child; Double-Blind Method; Female; Humans; Male; Pharyngitis; Pyrrolidonecarboxylic Acid; Recurrence; Thiazoles; Thiazolidines; Tonsillitis | 1994 |
Pidotimod activity against chronic bronchitis exacerbations.
Topics: Adjuvants, Immunologic; Aged; Bronchitis; Chronic Disease; Double-Blind Method; Female; Humans; Male; Middle Aged; Patient Dropouts; Pyrrolidonecarboxylic Acid; Thiazoles; Thiazolidines | 1994 |
Immunoactivity of pidotimod against episodes of recurrent tonsillitis in childhood.
Topics: Adjuvants, Immunologic; Adolescent; Anti-Bacterial Agents; Anti-Inflammatory Agents; Child; Child, Preschool; Double-Blind Method; Female; Humans; Male; Pyrrolidonecarboxylic Acid; Recurrence; Thiazoles; Thiazolidines; Tonsillitis | 1994 |
Immunoactivation by pidotimod in children with recurrent respiratory infections.
Topics: Adjuvants, Immunologic; Adolescent; Child; Child, Preschool; Double-Blind Method; Female; Humans; Interleukin-2; Leukocytes; Male; Phytohemagglutinins; Pyrrolidonecarboxylic Acid; Receptors, Interleukin-2; Recurrence; Respiratory Tract Infections; Thiazoles; Thiazolidines | 1994 |
[Pidotimod, a new biological response modifier, is able to partially prevent immune response changes related to surgical stress].
Topics: Adjuvants, Immunologic; Adolescent; Adult; Anesthesia, General; Antibody Formation; Complement C3; Complement C4; Double-Blind Method; Female; Humans; Immune System; Immunologic Deficiency Syndromes; Interleukin-2; Lymphocyte Activation; Lymphocyte Subsets; Male; Middle Aged; Neutrophils; Phagocytosis; Pyrrolidonecarboxylic Acid; Respiratory Burst; Stress, Physiological; Surgical Procedures, Operative; Thiazoles; Thiazolidines | 1993 |
Pidotimod in the management of vulvar papillomatosis: double-blind clinical trial versus placebo.
Topics: Administration, Oral; Adolescent; Adult; Biopsy; Colposcopy; Condylomata Acuminata; Double-Blind Method; Female; Humans; Immunologic Factors; Middle Aged; Pyrrolidonecarboxylic Acid; Thiazoles; Thiazolidines; Treatment Outcome; Vulvar Diseases | 1998 |
Prophylaxis with the novel immunomodulator pidotimod reduces the frequency and severity of upper respiratory tract infections in children with Down's syndrome.
Topics: Adolescent; Child; Child, Preschool; Down Syndrome; Female; Humans; Immunologic Factors; Incidence; Male; Pyrrolidonecarboxylic Acid; Recurrence; Respiratory Tract Infections; Severity of Illness Index; Thiazoles; Thiazolidines | 1999 |
Clinical evaluation and changes of the respiratory epithelium function after administration of Pidotimod in Greek children with recurrent respiratory tract infections.
Topics: Adjuvants, Immunologic; Child; Child, Preschool; Female; Greece; Humans; Male; Mucociliary Clearance; Prospective Studies; Pyrrolidonecarboxylic Acid; Respiratory Mucosa; Respiratory Tract Infections; Thiazoles; Thiazolidines; Treatment Outcome | 2002 |
33 other study(ies) available for pidotimod and thiazoles
| Article | Year |
|---|---|
Increased rate of survival in Streptococcus pneumoniae-infected rats treated with the new immunomodulator Pidotimod.
Topics: Adjuvants, Immunologic; Animals; Male; Pneumonia, Pneumococcal; Pyrrolidonecarboxylic Acid; Rats; Rats, Wistar; Thiazoles; Thiazolidines | 1992 |
Pidotimod stimulates natural killer cell activity and inhibits thymocyte cell death.
Topics: Adjuvants, Immunologic; Animals; Apoptosis; Calcium; Cellular Senescence; Cytotoxicity, Immunologic; Killer Cells, Natural; Mice; Mice, Inbred C3H; Pyrrolidonecarboxylic Acid; Spleen; T-Lymphocytes; Thiazoles; Thiazolidines | 1992 |
Immunopharmacology of Pidotimod: effect on natural killer cell activity and thymocyte cell death.
Topics: Animals; Apoptosis; Cell Death; Dexamethasone; Killer Cells, Natural; Mice; Mice, Inbred C3H; Pyrrolidonecarboxylic Acid; T-Lymphocytes; Thiazoles; Thiazolidines | 1992 |
Evaluation of the kinetics of the immunomodulating activity of Pidotimod on human neutrophils.
Topics: Adjuvants, Immunologic; Adult; Humans; Neutrophils; Phagocytosis; Pyrrolidonecarboxylic Acid; Thiazoles; Thiazolidines | 1992 |
Ex vivo evaluation of Pidotimod effect on immune response.
Topics: Adjuvants, Immunologic; Adult; Chemotaxis, Leukocyte; Humans; Immunity, Cellular; Lymphocyte Activation; Male; Phytohemagglutinins; Pyrrolidonecarboxylic Acid; Thiazoles; Thiazolidines | 1992 |
Activity of the new immunostimulant PGT/1A against experimental bacterial infections.
Topics: Adjuvants, Immunologic; Animals; Bacterial Infections; Male; Mice; Mice, Inbred ICR; Pyrrolidonecarboxylic Acid; Thiazoles; Thiazolidines | 1992 |
Effect of Pidotimod, a new immunostimulating agent, on some aspects of immune response. In vitro study.
Topics: Adjuvants, Immunologic; Complement System Proteins; Humans; Immunity, Cellular; Lymphocyte Activation; Lymphocytes; Neutrophils; Phagocytosis; Pyrrolidonecarboxylic Acid; Thiazoles; Thiazolidines | 1992 |
Simple high-performance liquid chromatographic method for the determination of PGT/1A, a new immunostimulating drug, in biological fluids.
Topics: Acetonitriles; Adjuvants, Immunologic; Adult; Chromatography, High Pressure Liquid; Humans; Injections, Intravenous; Male; Phosphates; Potassium; Potassium Compounds; Pyrrolidonecarboxylic Acid; Thiazoles; Thiazolidines | 1991 |
Activity of PGT/1A, a new immunostimulating drug, on macrophages and lymphocytes in immunodepressed mice.
Topics: Adjuvants, Immunologic; Animals; Bacterial Infections; Immunosuppression Therapy; Lymphocytes; Macrophages; Mice; Pyrrolidinones; Pyrrolidonecarboxylic Acid; Thiazoles; Thiazolidines | 1990 |
Gene expression for interleukin-2 and tumor necrosis factor-alpha in the spleen of old rats under physiological condition and during septic shock. Possible pharmacological modulation.
Topics: Aging; Animals; Blotting, Northern; Gene Expression Regulation; Immunologic Factors; Interleukin-2; Male; Pyrrolidonecarboxylic Acid; Rats; Rats, Sprague-Dawley; RNA; Shock, Septic; Spleen; Thiazoles; Thiazolidines; Tumor Necrosis Factor-alpha | 1994 |
Pidotimod. A new biological response modifier. Introduction.
Topics: Adjuvants, Immunologic; Animals; Bacterial Infections; Humans; Immunologic Factors; Pyrrolidonecarboxylic Acid; Thiazoles; Thiazolidines | 1994 |
Synthesis and preliminary pharmacological evaluation of pidotimod, its enantiomer, diastereomers and carboxamido derivatives.
Topics: Adjuvants, Immunologic; Animals; Bacterial Infections; Immunologic Factors; Macrophages; Male; Mice; Mice, Inbred Strains; Prednisolone; Pyrrolidonecarboxylic Acid; Stereoisomerism; Structure-Activity Relationship; Superoxides; Thiazoles; Thiazolidines | 1994 |
Analytical and chemical profile of pidotimod.
Topics: Calorimetry, Differential Scanning; Chemical Phenomena; Chemistry, Physical; Chromatography, High Pressure Liquid; Crystallography, X-Ray; Immunologic Factors; Isomerism; Magnetic Resonance Spectroscopy; Mass Spectrometry; Molecular Weight; Pyrrolidonecarboxylic Acid; Solubility; Spectrophotometry, Infrared; Spectrophotometry, Ultraviolet; Thermogravimetry; Thiazoles; Thiazolidines | 1994 |
Experimental immunological screening tests on pidotimod.
Topics: Adjuvants, Immunologic; Animals; Antibody Formation; B-Lymphocytes; Chemotaxis, Leukocyte; Dinitrochlorobenzene; Graft vs Host Reaction; Hypersensitivity, Delayed; Macrophages; Male; Mice; Mice, Inbred C57BL; Mice, Inbred Strains; Mononuclear Phagocyte System; Organ Size; Pyrrolidonecarboxylic Acid; Sheep; Spleen; T-Lymphocytes; Thiazoles; Thiazolidines; Thymus Gland | 1994 |
Protective effects of pidotimod against experimental bacterial infections in mice.
Topics: Adjuvants, Immunologic; Animals; Anti-Bacterial Agents; Cyclophosphamide; Enterobacteriaceae Infections; Immunosuppression Therapy; Lactams; Male; Mice; Mice, Inbred Strains; Pyrrolidonecarboxylic Acid; Thiazoles; Thiazolidines | 1994 |
Immunomodulating activity of pidotimod.
Topics: Adjuvants, Immunologic; Animals; Apoptosis; Calcimycin; Cell Division; DNA; Female; Flow Cytometry; Killer Cells, Natural; Male; Mice; Mice, Inbred C3H; Mitogens; Protein-Tyrosine Kinases; Pyrrolidonecarboxylic Acid; Spleen; T-Lymphocytes; Thiazoles; Thiazolidines; Tissue Plasminogen Activator; Tumor Cells, Cultured | 1994 |
Effects of pidotimod on macrophage functions in methylprednisolone-treated mice.
Topics: Adjuvants, Immunologic; Animals; Aspergillus fumigatus; Cell Adhesion; Cell Division; Cytokines; Female; Interferon-gamma; Lipopolysaccharides; Macrophages; Methylprednisolone; Mice; Mice, Inbred Strains; Nitric Oxide; Pyrrolidonecarboxylic Acid; Spores, Fungal; Thiazoles; Thiazolidines; Tumor Necrosis Factor-alpha | 1994 |
In vivo antiviral effects of pidotimod.
Topics: Adjuvants, Immunologic; Animals; Antiviral Agents; Cardiovirus Infections; Herpes Simplex; Influenza A virus; Male; Mengovirus; Mice; Orthomyxoviridae Infections; Pyrrolidonecarboxylic Acid; Thiazoles; Thiazolidines; Virus Diseases | 1994 |
Effects of pidotimod on the immune and the neuroendocrine system in the aging rat.
Topics: Adjuvants, Immunologic; Adrenocorticotropic Hormone; Aging; Animals; Cytokines; Immune System; Immunologic Factors; Interleukin-1; Lymphocytes; Male; Mitogens; Neurosecretory Systems; Pituitary-Adrenal System; Pyrrolidonecarboxylic Acid; Rats; Rats, Sprague-Dawley; Spleen; Thiazoles; Thiazolidines | 1994 |
General pharmacology of pidotimod and testing for drug interactions.
Topics: Animals; Anti-Infective Agents; Anti-Inflammatory Agents, Non-Steroidal; Autonomic Nervous System; Behavior, Animal; Central Nervous System; Diuresis; Dogs; Drug Interactions; Guinea Pigs; Hemodynamics; Immunologic Factors; In Vitro Techniques; Male; Mice; Muscle, Smooth; Pyrrolidonecarboxylic Acid; Rabbits; Rats; Respiration; Thiazoles; Thiazolidines | 1994 |
Toxicological evaluation of pidotimod.
Topics: Animals; Dogs; Female; Fertility; Lethal Dose 50; Male; Mice; Mice, Inbred Strains; Pyrrolidonecarboxylic Acid; Rats; Rats, Sprague-Dawley; Teratogens; Thiazoles; Thiazolidines | 1994 |
Genotoxicity testing of pidotimod in vitro and in vivo.
Topics: Animals; Bone Marrow; Bone Marrow Cells; Cells, Cultured; CHO Cells; Chromosome Aberrations; Cricetinae; DNA Repair; Erythrocytes; HeLa Cells; Humans; In Vitro Techniques; Mice; Micronucleus Tests; Mutagenicity Tests; Mutagens; Pyrrolidonecarboxylic Acid; Rats; Salmonella typhimurium; Thiazoles; Thiazolidines | 1994 |
Pharmacokinetics of pidotimod in rats and dogs.
Topics: Administration, Oral; Animals; Biological Availability; Chromatography, High Pressure Liquid; Dogs; Half-Life; Immunologic Factors; Injections, Intramuscular; Injections, Intravenous; Male; Pyrrolidonecarboxylic Acid; Rats; Rats, Inbred Strains; Thiazoles; Thiazolidines; Tissue Distribution | 1994 |
A new HPLC method for pidotimod plasma levels determination.
Topics: Adult; Chromatography, High Pressure Liquid; Humans; Immunologic Factors; Male; Pyrrolidonecarboxylic Acid; Thiazoles; Thiazolidines | 1993 |
[Pidotimod causes apoptotic cell death and inhibits the proliferative activity of YAC-1 tumor cells in vitro].
Topics: Adjuvants, Immunologic; Animals; Antineoplastic Agents; Apoptosis; Biological Transport; Calcium; Cell Division; DNA, Neoplasm; Drug Screening Assays, Antitumor; G2 Phase; Lymphoma, T-Cell; Mice; Mice, Inbred A; Mitosis; Neoplasm Proteins; Neoplastic Stem Cells; Phosphoproteins; Phosphorylation; Protein Processing, Post-Translational; Pyrrolidonecarboxylic Acid; T-Lymphocytes; Thiazoles; Thiazolidines; Tumor Cells, Cultured | 1993 |
[Potentiation of the resistance to viral and bacterial infections after pidotimod administration in mice].
Topics: Adjuvants, Immunologic; Animals; Bacterial Infections; Coxsackievirus Infections; Enterovirus B, Human; Female; Immunity, Innate; Influenza A virus; Mice; Mice, Inbred BALB C; Orthomyxoviridae Infections; Pyrrolidonecarboxylic Acid; Streptococcal Infections; Streptococcus agalactiae; Thiazoles; Thiazolidines; Virus Diseases | 1993 |
[Stimulation of B-cell immunity in the nude mice by pidotimod: immunohistochemical stucy of various lymphoid organs].
Topics: Adjuvants, Immunologic; Animals; Antibody Formation; B-Lymphocytes; Cell Differentiation; Immunoenzyme Techniques; Immunoglobulins; Immunologic Deficiency Syndromes; Intestinal Mucosa; Lung; Lymph Nodes; Lymphocyte Activation; Lymphoid Tissue; Mice; Mice, Nude; Pyrrolidonecarboxylic Acid; Spleen; Thiazoles; Thiazolidines | 1993 |
[Effect of pidotimod on phagocytosis and intracellular killing of Staphylococcus aureus by human circulating polymorphonuclear neutrophils and alveolar macrophages].
Topics: Adjuvants, Immunologic; Adolescent; Adult; Coloring Agents; Cytotoxicity, Immunologic; Female; Fluorescent Dyes; Humans; Hydrogen Peroxide; Indoles; Macrophage Activation; Macrophages, Alveolar; Male; Microscopy, Fluorescence; Neutrophils; Phagocytosis; Pyrrolidonecarboxylic Acid; Respiratory Burst; Staphylococcus aureus; Thiazoles; Thiazolidines | 1993 |
[Effect of pidotimod on the function of the human immune system: in vitro and ex vivo study].
Topics: Adjuvants, Immunologic; Administration, Oral; Adult; Aged; Aged, 80 and over; Aging; Antibody Formation; Chemotaxis, Leukocyte; Humans; Immune System; Interferon-gamma; Interleukin-1; Interleukin-2; Interleukin-6; Lymphocyte Activation; Lymphocyte Subsets; Mitogens; Muromonab-CD3; Neutrophils; Phagocytosis; Phytohemagglutinins; Pyrrolidonecarboxylic Acid; Tetradecanoylphorbol Acetate; Thiazoles; Thiazolidines | 1993 |
[Levels of interleukin-2 )IL-2 and tumor necrosis factor alpha (TNF-alpha) mRNA in aged rat spleen under physiological conditions and in septic shock: possible role of pidotimod in gene expression modulation].
Topics: Adjuvants, Immunologic; Aging; Animals; Escherichia coli Infections; Gene Expression Regulation; Interleukin-2; Male; Pyrrolidonecarboxylic Acid; Rats; Rats, Sprague-Dawley; RNA, Messenger; Shock, Septic; Spleen; Stimulation, Chemical; Thiazoles; Thiazolidines; Tumor Necrosis Factor-alpha | 1993 |
The in vitro effect of Pidotimod on some immune functions in cancer patients.
Topics: Adjuvants, Immunologic; Female; Humans; Immunity, Cellular; Immunologic Factors; Interleukin-2; Leukocytes, Mononuclear; Lymphocyte Activation; Male; Neoplasms; Pyrrolidonecarboxylic Acid; Thiazoles; Thiazolidines | 1997 |
Immune modulator pidotimod decreases the in vitro expression of CD30 in peripheral blood mononuclear cells of atopic asthmatic and normal children.
Topics: Asthma; Child; Child, Preschool; Cytokines; Down-Regulation; Female; Humans; Hypersensitivity; Immunologic Factors; Ki-1 Antigen; Leukocytes, Mononuclear; Male; Pyrrolidonecarboxylic Acid; T-Lymphocytes, Helper-Inducer; Thiazoles; Thiazolidines | 2004 |
Synergistic immunostimulating activity of pidotimod and red ginseng acidic polysaccharide against cyclophosphamide-induced immunosuppression.
Topics: Adjuvants, Immunologic; Animals; Body Weight; C-Reactive Protein; Cell Proliferation; Cell Survival; Cyclophosphamide; Drug Synergism; Immunosuppressive Agents; Killer Cells, Natural; Macrophages, Peritoneal; Male; Mice; Mice, Inbred BALB C; Nitric Oxide; Organ Size; Panax; Polysaccharides; Pyrrolidonecarboxylic Acid; Spleen; Tetrazolium Salts; Thiazoles; Thiazolidines | 2008 |