picrotoxin has been researched along with propofol in 31 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 13 (41.94) | 18.2507 |
| 2000's | 12 (38.71) | 29.6817 |
| 2010's | 4 (12.90) | 24.3611 |
| 2020's | 2 (6.45) | 2.80 |
| Authors | Studies |
|---|---|
| Biggio, G; Concas, A; Mascia, MP; Sanna, E; Santoro, G; Serra, M | 1 |
| Abu-Laban, A; Hasan, Z; Khatib, S | 1 |
| Garau, F; Harris, RA; Sanna, E | 1 |
| Crosby, G; Goto, T; Marota, JJ | 1 |
| Drummer, HL; Hasan, ZA; Tubbs, T; Woolley, DE; Zimmer, L | 1 |
| al-Hader, AF; Hasan, MM; Hasan, ZA; Takrouri, MS | 1 |
| Rasmussen, PA; Rutecki, PA; Yang, Y | 1 |
| Davies, PA; Hales, TG; Hanna, MC; Kirkness, EF | 1 |
| Biggio, G; Casula, A; Maciocco, E; Murgia, A; Sanna, E; Tuligi, G; Usala, M | 1 |
| Hemmings, HC; Murugaiah, KD | 1 |
| Ito, Y; Iwatsuki, N; Izumi, H; Karita, K; Sato, M | 1 |
| Ai, J; Kahnberg, P; Nielsen, M; Saederup, E; Squires, RF; Sterner, O; Witt, MR | 1 |
| Chen, CL; Chiu, TH; Yang, YR | 1 |
| Bai, D; Jackson, MF; MacDonald, JF; Orser, BA; Pennefather, P; Zhu, G | 1 |
| Abaigar, W; Bovill, JG; Laster, MJ; Sonner, JM; Stabernack, C; Xing, Y; Zhang, Y | 1 |
| Funahashi, M; Higuchi, H; Kohjitani, A; Matsuo, R; Mitoh, Y; Miyawaki, T; Shimada, M | 1 |
| Delbro, DS; Engberg, G; Erhardt, S; Schwieler, L | 1 |
| Qiu, DL; Shirasaka, T; Takasaki, M; Yoshimura, Y | 1 |
| Namiki, A; Ohmori, H; Sato, Y | 1 |
| Bickler, PE; Donohoe, PH; Estrada, S; Fahlman, CS; Feiner, JR; Schuyler, JA | 1 |
| Harrison, NL; Schofield, CM | 1 |
| Cao, J; Cui, M; Li, H; Sun, X; Xu, L; Xu, T; Yang, J; Zeng, B; Zhang, J; Zhang, Z | 1 |
| Gong, N; Wang, H; Wang, W; Xu, TL | 1 |
| Basson, MD; Kouatli, Y; Marsh, HM; Shiratsuchi, H; Yu, GX | 1 |
| Antognini, JF; Atherley, RJ; Jinks, SL; Kim, J; Kungys, G | 1 |
| Eberhardt, M; Fischer, MJ; Kistner, K; Leffler, A; Nau, C; Niedermirtl, F; Reeh, PW | 1 |
| Andrada, J; Jinks, SL | 1 |
| Abdel Razzak, RL; Alzoubi, KH; Hasan, ZA | 1 |
| Czajkowski, C; Ghosh, B; Tsao, TW | 1 |
| Gharpure, A; Hibbs, RE; Howard, RJ; Kim, JJ; Lindahl, E; Noviello, CM; Teng, J; Walsh, RM; Zhu, S; Zhuang, Y | 1 |
| Goodchild, J; Lansdell, SJ; Millar, NS; Puinean, AM; Sanders, VR; Smelt, CLC | 1 |
31 other study(ies) available for picrotoxin and propofol
| Article | Year |
|---|---|
The general anesthetic propofol enhances the function of gamma-aminobutyric acid-coupled chloride channel in the rat cerebral cortex.
Topics: Anesthetics; Animals; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Cerebral Cortex; Chloride Channels; gamma-Aminobutyric Acid; Male; Membrane Proteins; Pentobarbital; Picrotoxin; Pregnanediones; Propofol; Rats; Rats, Inbred Strains | 1990 |
Effects of propofol and thiopentone on picrotoxin convulsive threshold in the rabbit.
Topics: Animals; Anticonvulsants; Dose-Response Relationship, Drug; Injections, Intravenous; Male; Picrotoxin; Propofol; Rabbits; Seizures; Thiopental | 1995 |
Novel properties of homomeric beta 1 gamma-aminobutyric acid type A receptors: actions of the anesthetics propofol and pentobarbital.
Topics: Animals; Bicuculline; Female; gamma-Aminobutyric Acid; Pentobarbital; Picrotoxin; Propofol; Receptors, GABA-A; Strychnine; Xenopus laevis | 1995 |
Pentobarbitone, but not propofol, produces pre-emptive analgesia in the rat formalin model.
Topics: Analgesics; Anesthesia, Intravenous; Animals; Behavior, Animal; Disease Models, Animal; Formaldehyde; Male; Pain; Pentobarbital; Picrotoxin; Propofol; Rats; Rats, Sprague-Dawley; Time Factors | 1994 |
Comparison of the effects of propofol, diazepam and pentobarbital on hippocampal potentials evoked by prepyriform stimulation in the freely behaving rat.
Topics: Animals; Behavior, Animal; Cerebral Cortex; Diazepam; Electric Stimulation; Electroencephalography; Evoked Potentials; Female; Hippocampus; Pentobarbital; Picrotoxin; Propofol; Rats; Sleep | 1993 |
The anticonvulsant effects of propofol, diazepam, and thiopental, against picrotoxin-induced seizure in the rat.
Topics: Animals; Anticonvulsants; Diazepam; Female; Picrotoxin; Propofol; Rats; Rats, Sprague-Dawley; Seizures; Thiopental | 1993 |
Propofol inhibits epileptiform activity in rat hippocampal slices.
Topics: Analysis of Variance; Anesthetics, Intravenous; Animals; Anticonvulsants; Bicuculline; Convulsants; Drug Evaluation, Preclinical; Epilepsy; GABA Antagonists; Hypnotics and Sedatives; In Vitro Techniques; Male; Picrotoxin; Propofol; Rats; Rats, Sprague-Dawley | 1996 |
Insensitivity to anaesthetic agents conferred by a class of GABA(A) receptor subunit.
Topics: Amino Acid Sequence; Anesthetics, Intravenous; Animals; Bicuculline; Brain; Cell Line; Consensus Sequence; DNA, Complementary; Flumazenil; Flunitrazepam; GABA Agents; gamma-Aminobutyric Acid; Humans; Molecular Sequence Data; Muscimol; Pentobarbital; Picrotoxin; Pregnanolone; Propofol; Rats; Receptors, GABA-A; Recombinant Proteins; RNA, Messenger; Transfection | 1997 |
Direct activation of GABAA receptors by loreclezole, an anticonvulsant drug with selectivity for the beta-subunit.
Topics: Animals; Anticonvulsants; Bicuculline; Binding, Competitive; Bridged Bicyclo Compounds, Heterocyclic; Cell Membrane; Cerebral Cortex; Chloride Channels; Convulsants; Diazepam; DNA, Complementary; Female; gamma-Aminobutyric Acid; Humans; Kinetics; Macromolecular Substances; Male; Membrane Potentials; Oocytes; Picrotoxin; Propofol; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Recombinant Proteins; Triazoles; Xenopus laevis | 1996 |
Effects of intravenous general anesthetics on [3H]GABA release from rat cortical synaptosomes.
Topics: Aminobutyrates; Anesthesia, General; Anesthetics, Intravenous; Animals; Baclofen; Bicuculline; Calcium; Cerebral Cortex; GABA Agonists; GABA Antagonists; GABA-A Receptor Agonists; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Male; Nerve Endings; Nipecotic Acids; Picrotoxin; Potassium Chloride; Proline; Propofol; Rats; Rats, Sprague-Dawley; Reproducibility of Results; Synaptic Transmission; Synaptosomes; Tritium | 1998 |
Suppression of parasympathetic reflex vasodilatation in the lower lip of the cat by isoflurane, propofol, ketamine and pentobarbital: implications for mechanisms underlying the production of anaesthesia.
Topics: Anesthetics, Inhalation; Anesthetics, Intravenous; Animals; Cats; Dose-Response Relationship, Drug; Electric Stimulation; Female; GABA Antagonists; Hypnotics and Sedatives; Isoflurane; Ketamine; Lip; Male; Parasympathetic Nervous System; Pentobarbital; Picrotoxin; Propofol; Reflex; Vasodilation | 1998 |
Honokiol and magnolol increase the number of [3H] muscimol binding sites three-fold in rat forebrain membranes in vitro using a filtration assay, by allosterically increasing the affinities of low-affinity sites.
Topics: Allosteric Regulation; Androstanes; Animals; Azasteroids; Binding Sites; Biphenyl Compounds; Cell Membrane; Central Nervous System Depressants; Cerebellum; Diflunisal; Drugs, Chinese Herbal; Flunitrazepam; GABA Antagonists; gamma-Aminobutyric Acid; Kinetics; Lignans; Muscimol; Picrotoxin; Propofol; Prosencephalon; Rats; Receptors, GABA-A; Tritium | 1999 |
Activation of rat locus coeruleus neuron GABA(A) receptors by propofol and its potentiation by pentobarbital or alphaxalone.
Topics: Anesthetics; Anesthetics, Intravenous; Animals; Baclofen; Barium Compounds; Bicuculline; Chlorides; Diazepam; Drug Synergism; GABA Antagonists; GABA Modulators; gamma-Aminobutyric Acid; Ionophores; Locus Coeruleus; Male; Neurons; Pentobarbital; Picrotoxin; Pregnanediones; Propofol; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Zinc Compounds | 1999 |
Distinct functional and pharmacological properties of tonic and quantal inhibitory postsynaptic currents mediated by gamma-aminobutyric acid(A) receptors in hippocampal neurons.
Topics: Animals; Bicuculline; Cells, Cultured; Dose-Response Relationship, Drug; Drug Synergism; Excitatory Postsynaptic Potentials; GABA Antagonists; GABA-A Receptor Antagonists; Hippocampus; Hypnotics and Sedatives; In Vitro Techniques; Mice; Midazolam; Models, Neurological; Neural Inhibition; Neurons; Patch-Clamp Techniques; Picrotoxin; Propofol; Pyridazines; Receptors, GABA-A | 2001 |
GABA(A) receptor blockade antagonizes the immobilizing action of propofol but not ketamine or isoflurane in a dose-related manner.
Topics: Anesthetics, Dissociative; Anesthetics, Inhalation; Anesthetics, Intravenous; Animals; Bicuculline; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; GABA Antagonists; GABA-A Receptor Antagonists; Glycine Agents; Infusions, Intravenous; Injections, Intraperitoneal; Isoflurane; Ketamine; Male; Picrotoxin; Propofol; Pulmonary Alveoli; Pyridazines; Rats; Rats, Sprague-Dawley; Strychnine | 2003 |
Suppression of the hyperpolarization-activated inward current contributes to the inhibitory actions of propofol on rat CA1 and CA3 pyramidal neurons.
Topics: Anesthetics, Intravenous; Animals; Cyclic Nucleotide-Gated Cation Channels; Electrophysiology; GABA Antagonists; GABA-A Receptor Antagonists; Hippocampus; Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels; Ion Channels; Male; Membrane Potentials; Microelectrodes; Organ Culture Techniques; Picrotoxin; Potassium Channels; Propofol; Pyramidal Cells; Rats; Rats, Sprague-Dawley | 2003 |
The anaesthetic agent propofol interacts with GABA(B)-receptors: an electrophysiological study in rat.
Topics: Anesthetics, Intravenous; Animals; Dose-Response Relationship, Drug; Electrophysiology; Extracellular Space; GABA Antagonists; Male; Neurons; Organophosphorus Compounds; Patch-Clamp Techniques; Picrotoxin; Propofol; Rats; Rats, Sprague-Dawley; Receptors, GABA-B; Substantia Nigra | 2003 |
The effects of propofol on hypothalamic paraventricular nucleus neurons in the rat.
Topics: Anesthetics, Intravenous; Animals; Calcium Channels; Electric Stimulation; Electrophysiology; Excitatory Postsynaptic Potentials; GABA Antagonists; Glycine Agents; Immunohistochemistry; In Vitro Techniques; Male; Membrane Potentials; Neurons; Paraventricular Hypothalamic Nucleus; Patch-Clamp Techniques; Picrotoxin; Potassium Channel Blockers; Propofol; Rats; Rats, Wistar; Receptors, GABA-A; Strychnine | 2004 |
The anticonvulsant action of propofol on epileptiform activity in rat hippocampal slices.
Topics: Adenosine; Adenosine A1 Receptor Antagonists; Adenosine A2 Receptor Antagonists; Aminophylline; Anesthetics, Intravenous; Animals; Anticonvulsants; Bicuculline; Dose-Response Relationship, Drug; Electric Stimulation; Epilepsy; Excitatory Postsynaptic Potentials; Female; GABA Antagonists; Hippocampus; In Vitro Techniques; Male; Phosphodiesterase Inhibitors; Picrotoxin; Propofol; Rats; Rats, Sprague-Dawley; Synaptic Transmission; Theobromine; Xanthines | 2004 |
Mild hypothermia, but not propofol, is neuroprotective in organotypic hippocampal cultures.
Topics: Anesthetics, Intravenous; Animals; Calcium; Cell Survival; Cerebral Cortex; GABA Antagonists; Hippocampus; Hypothermia, Induced; Neurons; Neuroprotective Agents; Organ Culture Techniques; Picrotoxin; Propofol; Pyramidal Cells; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Receptors, Glutamate | 2005 |
Transmembrane residues define the action of isoflurane at the GABAA receptor alpha-3 subunit.
Topics: Anesthetics, Inhalation; Anesthetics, Intravenous; Cell Line; Dose-Response Relationship, Drug; GABA Antagonists; gamma-Aminobutyric Acid; Humans; Isoflurane; Membrane Potentials; Molecular Sequence Data; Mutagenesis, Site-Directed; Patch-Clamp Techniques; Picrotoxin; Propofol; Protein Structure, Tertiary; Protein Subunits; Receptors, GABA-A; Transfection | 2005 |
Propofol effects on excitatory synaptic efficacy in the CA1 region of the developing hippocampus.
Topics: Age Factors; Animals; Animals, Newborn; Chlorides; Dose-Response Relationship, Drug; Drug Interactions; Electric Stimulation; Excitatory Postsynaptic Potentials; GABA Antagonists; Hippocampus; Hypnotics and Sedatives; In Vitro Techniques; Long-Term Synaptic Depression; Patch-Clamp Techniques; Picrotoxin; Propofol; Rats; Rats, Wistar; Synaptic Transmission; Time Factors | 2005 |
Changes of K+ -Cl- cotransporter 2 (KCC2) and circuit activity in propofol-induced impairment of long-term potentiation in rat hippocampal slices.
Topics: Analysis of Variance; Anesthetics, Intravenous; Animals; Animals, Newborn; Dose-Response Relationship, Drug; Dose-Response Relationship, Radiation; Drug Interactions; Electric Stimulation; Excitatory Postsynaptic Potentials; GABA Antagonists; Hippocampus; In Vitro Techniques; K Cl- Cotransporters; Male; Neural Inhibition; Picrotoxin; Propofol; Rats; Rats, Sprague-Dawley; Symporters | 2006 |
Propofol inhibits pressure-stimulated macrophage phagocytosis via the GABAA receptor and dysregulation of p130cas phosphorylation.
Topics: Anesthetics, Intravenous; Cell Line; Crk-Associated Substrate Protein; Dose-Response Relationship, Drug; GABA Antagonists; Humans; Macrophages; Phagocytosis; Phosphorylation; Picrotoxin; Pressure; Propofol; Pyridazines; Receptors, GABA-A; RNA Interference; RNA, Small Interfering; Signal Transduction; Stress, Mechanical; Time Factors | 2009 |
Propofol produces immobility via action in the ventral horn of the spinal cord by a GABAergic mechanism.
Topics: Action Potentials; Anesthetics, Inhalation; Anesthetics, Intravenous; Animals; Anterior Horn Cells; Decerebrate State; GABA Antagonists; gamma-Aminobutyric Acid; Immobilization; Isoflurane; Male; Movement; Pain Threshold; Picrotoxin; Posterior Horn Cells; Propofol; Rats; Rats, Sprague-Dawley; Receptors, GABA-A | 2009 |
The general anesthetic propofol excites nociceptors by activating TRPV1 and TRPA1 rather than GABAA receptors.
Topics: Anesthetics, Intravenous; Animals; Calcitonin Gene-Related Peptide; GABA Antagonists; Ganglia, Spinal; Gene Expression Regulation; HEK293 Cells; Humans; Inflammation; Mice; Mice, Knockout; Neurons; Nociceptors; Picrotoxin; Propofol; Receptors, GABA-A; Recombinant Proteins; Transient Receptor Potential Channels; TRPA1 Cation Channel; TRPV Cation Channels | 2010 |
Validation and insights of anesthetic action in an early vertebrate network: the isolated lamprey spinal cord.
Topics: Algorithms; Anesthetics; Anesthetics, Inhalation; Anesthetics, Intravenous; Animals; Dose-Response Relationship, Drug; Electric Stimulation; GABA-A Receptor Antagonists; Glutamic Acid; In Vitro Techniques; Isoflurane; Lampreys; Locomotion; Motor Activity; Nerve Net; Physical Stimulation; Picrotoxin; Propofol; Spinal Cord; Spinal Nerve Roots; Strychnine; Swimming | 2011 |
Comparison between the effect of propofol and midazolam on picrotoxin-induced convulsions in rat.
Topics: Administration, Intravenous; Animals; Anticonvulsants; Convulsants; Dose-Response Relationship, Drug; Female; Midazolam; Picrotoxin; Propofol; Rats, Sprague-Dawley; Seizures; Time Factors | 2014 |
A chimeric prokaryotic-eukaryotic pentameric ligand gated ion channel reveals interactions between the extracellular and transmembrane domains shape neurosteroid modulation.
Topics: Animals; Bacterial Proteins; Cell Membrane; Chlorides; Etomidate; Extracellular Space; gamma-Aminobutyric Acid; Humans; Ligand-Gated Ion Channels; Membrane Potentials; Mutation; Neurotransmitter Agents; Oocytes; Pentobarbital; Picrotoxin; Propofol; Protein Domains; Protons; Receptors, GABA-B; Recombinant Fusion Proteins; Xenopus laevis | 2017 |
Shared structural mechanisms of general anaesthetics and benzodiazepines.
Topics: Allosteric Regulation; Anesthetics, General; Barbiturates; Benzodiazepines; Bicuculline; Binding Sites; Binding, Competitive; Cryoelectron Microscopy; Diazepam; Electrophysiology; Etomidate; Flumazenil; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Humans; Ligands; Models, Molecular; Molecular Conformation; Molecular Dynamics Simulation; Phenobarbital; Picrotoxin; Propofol; Receptors, GABA-A | 2020 |
Agonist and antagonist properties of an insect GABA-gated chloride channel (RDL) are influenced by heterologous expression conditions.
Topics: 3' Untranslated Regions; Amino Acid Sequence; Animals; Bees; Chloride Channel Agonists; Chloride Channels; Drosophila melanogaster; Drosophila Proteins; Female; gamma-Aminobutyric Acid; Picrotoxin; Propofol; Receptors, Glycine; Sesterterpenes; Xenopus laevis | 2021 |