picrotoxin has been researched along with pregnanolone in 46 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (2.17) | 18.7374 |
| 1990's | 18 (39.13) | 18.2507 |
| 2000's | 21 (45.65) | 29.6817 |
| 2010's | 6 (13.04) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Brann, DW; Kolbeck, RC; Mahesh, VB; Putnam, CD | 1 |
| Brann, DW; Mahesh, VB; Putnam, CD | 1 |
| Kirkness, EF; Turner, AJ | 1 |
| Costa, AM; ffrench-Mullen, JM; Smith, SS; Spence, KT | 1 |
| Bitran, D; McLeod, M; Shiekh, M | 1 |
| Brinton, RD | 1 |
| Bähring, R; Grantyn, R; Martelli, EA; Standhardt, H | 1 |
| Li, SY; Pelletier, G; Vincens, M | 1 |
| Dartois, E; Fillion, G; Haour, F; Marquette, C; Moyse, E; Popelier, M; Vincens, M | 1 |
| André, M; Arancibia, S; Belmar, J; Tapia-Arancibia, L | 1 |
| Dayanithi, G; Tapia-Arancibia, L | 1 |
| Chen, SW; Davies, MF; Loew, GH; Rodriguez, L | 1 |
| Davies, PA; Hales, TG; Hanna, MC; Kirkness, EF | 1 |
| Bhave, SV; Hoffmann, E; Hoffmann, PL; Olsen, RW; Tabakoff, B; Tobin, AJ; Tyndale, RF | 1 |
| Campos, MG; Hernández, R; Montaño, LM; Perusquía, M; Villalón, CM | 1 |
| Bäckström, T; Johansson, S; Landgren, S; Wang, MD | 1 |
| Hirst, JJ; Nicol, MB; Walker, D | 1 |
| Fiszer de Plazas, S; Mitridate de Novara, AM; Rodríguez Gil, DJ; Viapiano, MS | 1 |
| Bitran, D; Dugan, M; Ellis, R; Foley, M; Renda, P | 1 |
| Beart, PM; Crossley, KJ; Hirst, JJ; Walker, DW | 1 |
| Audette, D; Bitran, D; Foley, M; Frye, CA; Leslie, N | 1 |
| Bidziński, A; Członkowska, AI; Krzaścik, P; Płaźnik, A; Siemiatkowski, M; Sienkiewicz-Jarosz, H; Szyndler, J | 1 |
| Jaako, K; Kaasik, A; Kalda, A; Zharkovsky, A | 1 |
| Findlay, GS; Harris, RA; Harrison, NL; Ueno, S | 1 |
| Bidziński, A; Członkowska, AI; Krzaścik, P; Maciejak, P; Płaźnik, A; Siemiatkowski, M; Sienkiewicz-Jarosz, H; Szyndler, J | 1 |
| Bidziński, A; Członkowska, AI; Kostowski, W; Krzaścik, P; Maciejak, P; Plaznik, A; Szyndler, J; Walkowiak, J | 1 |
| Altobelli, D; Cannizzaro, C; Martire, M; Maurizi, S; Preziosi, P | 1 |
| Dillon, GH; Huang, RQ | 1 |
| Fjalland, B; Hansen, SL; Jackson, MB | 1 |
| Matsumoto, K; Murakami, Y; Nomura, H; Takahata, H; Taki, K; Watanabe, H | 1 |
| Calvo, DJ; Goutman, JD | 1 |
| Frye, CA; Petralia, SM | 1 |
| Izumi, Y; Murayama, K; Zorumski, CF | 1 |
| Bernal-Morales, B; Contreras, CM; Gutièrrez-Garcìa, AG; Rodrìguez-Landa, JF; Saavedra, M | 1 |
| Marx, CE; Moore, SD; Morrow, AL; Wang, C; Wilson, WA | 1 |
| Pericić, D; Strac, DS; Vlainić, J | 1 |
| Furukawa, K; Kita, A | 1 |
| Gillardin, JM; Heulard, I; Verleye, M | 1 |
| Brinton, RD; Wang, JM | 1 |
| Kumar, A; Singh, A | 1 |
| Arora, SK; Chakrabarti, A; Hota, D; Khanduja, KL; Prakash, A; Singh, S | 1 |
| Akram, A; Gibson, CL; Grubb, BD; Radley, E | 1 |
| Cao, Z; Hammock, BD; Lein, PJ; McCoy, M; Pessah, IN; Rogawski, MA | 1 |
| Chesnoy-Marchais, D | 1 |
| Aitta-Aho, T; den Hollander, B; Korpi, ER; Manner, AK; Uusi-Oukari, M; Vashchinkina, E; Vekovischeva, O | 1 |
| Halbhuber, L; Kilb, W; Lombardi, A; Luhmann, HJ; Okabe, A; Sharopov, S; Uehara, R; Winkler, P | 1 |
46 other study(ies) available for picrotoxin and pregnanolone
| Article | Year |
|---|---|
Inhibition of uterine contractility by progesterone and progesterone metabolites: mediation by progesterone and gamma amino butyric acidA receptor systems.
Topics: 5-alpha-Dihydroprogesterone; Animals; Depression, Chemical; Diestrus; Drug Interactions; Female; GABA-A Receptor Antagonists; Mifepristone; Picrotoxin; Pregnanediones; Pregnanolone; Progesterone; Rats; Receptors, GABA-A; Receptors, Progesterone; Uterine Contraction | 1991 |
Gamma-aminobutyric acidA receptors mediate 3 alpha-hydroxy-5 alpha-pregnan-20-one-induced gonadotropin secretion.
Topics: Animals; Dose-Response Relationship, Drug; Female; Follicle Stimulating Hormone; Gonadotropins; Luteinizing Hormone; Mifepristone; Picrotoxin; Pregnanes; Pregnanolone; Rats; Rats, Inbred Strains; Receptors, GABA-A | 1990 |
The stimulatory effects of secobarbital and pregnanolone on the GABAA receptor can be blocked selectively.
Topics: Animals; Anthelmintics; Cerebral Cortex; In Vitro Techniques; Ivermectin; Muscimol; Phenobarbital; Picrotoxin; Pregnanes; Pregnanolone; Radioligand Assay; Receptors, GABA-A; Secobarbital; Sesterterpenes; Swine; Synaptic Membranes | 1988 |
Withdrawal from the endogenous steroid progesterone results in GABAA currents insensitive to benzodiazepine modulation in rat CA1 hippocampus.
Topics: Animals; Benzodiazepines; Brain Chemistry; Chloride Channels; Electrophysiology; Female; GABA Antagonists; GABA Modulators; gamma-Aminobutyric Acid; Hippocampus; Ion Channel Gating; Lorazepam; Picrotoxin; Pregnanolone; Progesterone; Rats; Receptors, GABA-A; Substance Withdrawal Syndrome | 1995 |
Anxiolytic effect of progesterone is mediated by the neurosteroid allopregnanolone at brain GABAA receptors.
Topics: Analysis of Variance; Animals; Anti-Anxiety Agents; Azasteroids; Brain; Cholestenone 5 alpha-Reductase; Dihydrotestosterone; Estrus; Female; Mifepristone; Ovariectomy; Ovary; Oxidoreductases; Picrotoxin; Pregnanolone; Progesterone; Rats; Receptors, GABA-A | 1995 |
The neurosteroid 3 alpha-hydroxy-5 alpha-pregnan-20-one induces cytoarchitectural regression in cultured fetal hippocampal neurons.
Topics: Analysis of Variance; Animals; Anti-Anxiety Agents; Cell Death; Cell Division; Cell Survival; Cells, Cultured; Chlorides; Estradiol; Fetus; Hippocampus; Isomerism; Kinetics; Neurites; Neurons; Picrotoxin; Pregnanolone; Progesterone; Rats; Time Factors | 1994 |
GABA-activated chloride currents of postnatal mouse retinal ganglion cells are blocked by acetylcholine and acetylcarnitine: how specific are ion channels in immature neurons?
Topics: Acetylcarnitine; Acetylcholine; Action Potentials; Animals; Bicuculline; Chloride Channels; Clonazepam; GABA Antagonists; gamma-Aminobutyric Acid; Glycine; Mice; Mice, Inbred C57BL; Neurons; Patch-Clamp Techniques; Pentobarbital; Picrotoxin; Potassium Chloride; Pregnanolone; Quinoxalines; Retina; Retinal Ganglion Cells; Strychnine; Substrate Specificity; Tetrodotoxin; Zinc | 1994 |
Inhibitory effect of 5 beta-pregnan-3 alpha-o1-20-one on gonadotropin-releasing hormone gene expression in the male rat.
Topics: Animals; Autoradiography; Gene Expression Regulation; Gonadotropin-Releasing Hormone; Hypothalamus; In Situ Hybridization; Injections, Intraperitoneal; Male; Muscimol; Picrotoxin; Pregnanolone; Rats; Rats, Sprague-Dawley; Receptors, GABA; RNA, Messenger | 1994 |
Autoradiographic study of neurosteroid binding sites labelled with [35S]-TBPS in brain of different species.
Topics: Animals; Autoradiography; Brain; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Cerebral Cortex; Convulsants; Female; Guinea Pigs; Male; Mesencephalon; Mice; Mice, Inbred C3H; Organ Specificity; Picrotoxin; Pregnanolone; Rats; Rats, Wistar; Receptors, Steroid; Species Specificity; Sulfur Radioisotopes | 1993 |
Neuroactive steroids modulate GABA inhibition of hypothalamic somatostatin release.
Topics: Animals; Bicuculline; Cells, Cultured; Desoxycorticosterone; Drug Synergism; GABA Antagonists; GABA Modulators; Hypothalamus; Neurons; Picrotoxin; Pregnanolone; Rats; Rats, Sprague-Dawley; Somatostatin | 1995 |
Rise in intracellular calcium via a nongenomic effect of allopregnanolone in fetal rat hypothalamic neurons.
Topics: Animals; Bicuculline; Calcium; Cell Membrane; Electrophysiology; Fetus; GABA Modulators; Hypothalamus; Neurons; Pertussis Toxin; Picrotoxin; Pregnanolone; Rats; Rats, Sprague-Dawley; Sensitivity and Specificity; Virulence Factors, Bordetella | 1996 |
The hyperphagic effect of 3 alpha-hydroxylated pregnane steroids in male rats.
Topics: Animals; Anxiety; Dose-Response Relationship, Drug; Eating; Feeding Behavior; Flumazenil; GABA Antagonists; GABA Modulators; GABA-A Receptor Antagonists; Male; Picrotoxin; Pregnanes; Pregnanolone; Rats; Rats, Sprague-Dawley | 1996 |
Insensitivity to anaesthetic agents conferred by a class of GABA(A) receptor subunit.
Topics: Amino Acid Sequence; Anesthetics, Intravenous; Animals; Bicuculline; Brain; Cell Line; Consensus Sequence; DNA, Complementary; Flumazenil; Flunitrazepam; GABA Agents; gamma-Aminobutyric Acid; Humans; Molecular Sequence Data; Muscimol; Pentobarbital; Picrotoxin; Pregnanolone; Propofol; Rats; Receptors, GABA-A; Recombinant Proteins; RNA, Messenger; Transfection | 1997 |
Pentobarbital decreases the gamma-aminobutyric acidA receptor subunit gamma-2 long/short mRNA ratio by a mechanism distinct from receptor occupation.
Topics: Animals; Ethanol; GABA Modulators; Hexobarbital; Pentobarbital; Picrotoxin; Pregnanolone; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; RNA Splicing; RNA, Messenger | 1997 |
Inhibitory effect of sex steroids on guinea-pig airway smooth muscle contractions.
Topics: Animals; Bicuculline; Calcium; GABA Antagonists; GABA-A Receptor Antagonists; Guinea Pigs; Male; Membrane Potentials; Muscle Contraction; Muscle, Smooth; Picrotoxin; Pregnanolone; Progesterone; Trachea | 1997 |
Interaction between 3 alpha-hydroxy-5 alpha-pregnan-20-one and carbachol in the control of neuronal excitability in hippocampal slices of female rats in defined phases of the oestrus.
Topics: Action Potentials; Animals; Atropine; Carbachol; Drug Synergism; Estradiol; Estrus; Female; GABA Antagonists; GABA Modulators; Hippocampus; Muscarinic Agonists; Muscarinic Antagonists; Neurons; Picrotoxin; Pregnanolone; Progesterone; Rats; Rats, Sprague-Dawley; Receptors, GABA-A | 1998 |
Effects of pregnanolone on behavioural parameters and the responses to GABA(A) receptor antagonists in the late gestation fetal sheep.
Topics: Animals; Bicuculline; Electroencephalography; Electromyography; Electrooculography; Embryonic and Fetal Development; Female; GABA Antagonists; Gestational Age; Picrotoxin; Pregnancy; Pregnanolone; Receptors, GABA-A; Respiration; Sheep | 1999 |
Synaptic membrane freezing affects modulatory sites in avian central nervous system GABA(A) receptor.
Topics: Animals; Binding Sites; Chickens; Drug Synergism; Freezing; GABA Modulators; gamma-Aminobutyric Acid; Hypnotics and Sedatives; Pentobarbital; Picrotoxin; Pregnanolone; Receptors, GABA-A; Sesterterpenes; Synaptic Membranes; Tectum Mesencephali; Tritium | 1999 |
Anxiolytic effects of the neuroactive steroid pregnanolone (3 alpha-OH-5 beta-pregnan-20-one) after microinjection in the dorsal hippocampus and lateral septum.
Topics: Animals; Anti-Anxiety Agents; Behavior, Animal; Chloride Channels; Dose-Response Relationship, Drug; Electroshock; Flumazenil; GABA Modulators; GABA-A Receptor Antagonists; Hippocampus; Isoquinolines; Male; Microinjections; Picrotoxin; Pregnanolone; Rats; Rats, Long-Evans; Receptors, GABA-A; Septum of Brain | 1999 |
Characterisation of GABA(A) receptors in fetal, neonatal and adult ovine brain: region and age related changes and the effects of allopregnanolone.
Topics: Aging; Animals; Animals, Newborn; Binding, Competitive; Brain; Brain Stem; Bridged Bicyclo Compounds, Heterocyclic; Dose-Response Relationship, Drug; Female; Fetus; Frontal Lobe; GABA Antagonists; gamma-Aminobutyric Acid; Hypothalamus; Male; Picrotoxin; Pregnancy; Pregnanolone; Receptors, GABA-A; Sheep; Sulfur Radioisotopes | 2000 |
Activation of peripheral mitochondrial benzodiazepine receptors in the hippocampus stimulates allopregnanolone synthesis and produces anxiolytic-like effects in the rat.
Topics: Analysis of Variance; Animals; Anxiety; GABA Antagonists; Hippocampus; Indoleacetic Acids; Isoquinolines; Male; Mitochondria; Picrotoxin; Pregnanolone; Rats; Rats, Long-Evans; Receptors, GABA-A | 2000 |
The effects of neurosteroids on picrotoxin-, bicuculline- and NMDA-induced seizures, and a hypnotic effect of ethanol.
Topics: Animals; Bicuculline; Central Nervous System Depressants; Convulsants; Dehydroepiandrosterone Sulfate; Desoxycorticosterone; Dose-Response Relationship, Drug; Ethanol; Injections, Intraperitoneal; Injections, Intraventricular; Male; Mice; N-Methylaspartate; Picrotoxin; Pregnanediones; Pregnanolone; Pregnenolone; Progesterone; Reflex; Seizures; Sleep; Steroids | 2000 |
Dehydroepiandrosterone sulphate prevents oxygen-glucose deprivation-induced injury in cerebellar granule cell culture.
Topics: 1-Methyl-4-phenylpyridinium; Animals; Apoptosis; Cell Count; Cell Hypoxia; Cell Survival; Cells, Cultured; Cerebellum; Colchicine; Dehydroepiandrosterone Sulfate; Dizocilpine Maleate; GABA Modulators; Glucose; Glutamic Acid; Hypoxia-Ischemia, Brain; Neuroprotective Agents; Pentobarbital; Picrotoxin; Pregnanolone; Rats; Rats, Wistar; Receptors, GABA-A; Stereoisomerism | 2001 |
Allosteric modulation in spontaneously active mutant gamma-aminobutyric acidA receptors.
Topics: Allosteric Regulation; Animals; Bicuculline; Electric Conductivity; Female; Flunitrazepam; GABA Antagonists; GABA Modulators; Patch-Clamp Techniques; Pentobarbital; Picrotoxin; Pregnanolone; Protein Isoforms; Receptors, GABA-A; Xenopus laevis | 2001 |
Tolerance to the anticonvulsant activity of midazolam and allopregnanolone in a model of picrotoxin seizures.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Dopamine; Drug Combinations; Drug Tolerance; Male; Mice; Midazolam; Muscle, Skeletal; Picrotoxin; Pregnanolone; Receptors, GABA-A; Seizures | 2001 |
Antagonism of picrotoxin-induced changes in dopamine and serotonin metabolism by allopregnanolone and midazolam.
Topics: Amino Acids; Animals; Convulsants; Dopamine; Dose-Response Relationship, Drug; GABA Antagonists; GABA Modulators; Injections, Intraventricular; Male; Mice; Microinjections; Midazolam; Picrotoxin; Pregnanolone; Seizures; Serotonin | 2002 |
Prenatal diazepam exposure functionally alters the GABA(A) receptor that modulates [3H]noradrenaline release from rat hippocampal synaptosomes.
Topics: Allosteric Regulation; Animals; Baclofen; Bicuculline; Diazepam; Female; Fetal Proteins; GABA Agonists; GABA Antagonists; Hippocampus; Male; Mental Disorders; Nerve Tissue Proteins; Norepinephrine; Picrotoxin; Pregnancy; Pregnanolone; Prenatal Exposure Delayed Effects; Protein Subunits; Rats; Rats, Wistar; Receptors, GABA-A; Synaptosomes | 2002 |
Functional characterization of GABA(A) receptors in neonatal hypothalamic brain slice.
Topics: Anesthetics; Animals; Animals, Newborn; Anticonvulsants; Carbolines; Convulsants; Dehydroepiandrosterone Sulfate; Diazepam; Diuretics; Female; Furosemide; GABA Agonists; GABA Modulators; gamma-Aminobutyric Acid; Hypothalamus; Male; Membrane Potentials; Organ Culture Techniques; Patch-Clamp Techniques; Picrotoxin; Pregnanolone; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Triazoles; Zinc; Zolpidem | 2002 |
Modulation of GABAA receptors and neuropeptide secretion by the neurosteroid allopregnanolone in posterior and intermediate pituitary.
Topics: alpha-MSH; Animals; Dose-Response Relationship, Drug; Drug Synergism; GABA Antagonists; gamma-Aminobutyric Acid; Male; Nerve Endings; Neuropeptides; Patch-Clamp Techniques; Picrotoxin; Pituitary Gland; Pituitary Gland, Posterior; Pregnanolone; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Time Factors; Vasopressins | 2003 |
Long-term social isolation enhances picrotoxin seizure susceptibility in mice: up-regulatory role of endogenous brain allopregnanolone in GABAergic systems.
Topics: Animals; Brain; Dose-Response Relationship, Drug; Male; Mice; Picrotoxin; Pregnanolone; Receptors, GABA-A; Seizures; Social Isolation; Time; Up-Regulation | 2003 |
Studies on the mechanisms of action of picrotoxin, quercetin and pregnanolone at the GABA rho 1 receptor.
Topics: Animals; DNA, Complementary; Dose-Response Relationship, Drug; Electrophysiology; Evoked Potentials; GABA Antagonists; gamma-Aminobutyric Acid; Humans; Kinetics; Oocytes; Patch-Clamp Techniques; Picrotoxin; Pregnanolone; Quercetin; Receptors, GABA-B; Recombinant Proteins; Xenopus laevis | 2004 |
In the ventral tegmental area picrotoxin blocks FGIN 1-27-induced increases in sexual behavior of rats and hamsters.
Topics: Animals; Central Nervous System Stimulants; Cricetinae; Drug Interactions; Estradiol; Female; GABA Antagonists; Indoleacetic Acids; Motor Activity; Picrotoxin; Pregnanolone; Progesterone; Rats; Rats, Long-Evans; Sexual Behavior, Animal; Stimulation, Chemical; Ventral Tegmental Area | 2005 |
Effects of neurosteroid 3alpha-hydroxy-5alpha-pregnan-20-one on ethanol-mediated paired-pulse depression of population spikes in the CA1 region of rat hippocampal slices.
Topics: Action Potentials; Animals; Animals, Newborn; Central Nervous System Depressants; Cyclodextrins; Dose-Response Relationship, Drug; Drug Interactions; Electric Stimulation; Ethanol; GABA Antagonists; Hippocampus; In Vitro Techniques; Neural Inhibition; Patch-Clamp Techniques; Picrotoxin; Pregnanolone; Progesterone; Rats; Synaptic Transmission | 2006 |
Allopregnanolone reduces immobility in the forced swimming test and increases the firing rate of lateral septal neurons through actions on the GABAA receptor in the rat.
Topics: Action Potentials; Animals; Antidepressive Agents; Behavior, Animal; Dose-Response Relationship, Drug; Female; GABA Antagonists; Motor Activity; Neurons; Ovariectomy; Picrotoxin; Pregnanolone; Rats; Rats, Wistar; Reaction Time; Receptors, GABA-A; Septal Nuclei; Swimming; Time Factors | 2007 |
Neurosteroid modulation of GABAergic neurotransmission in the central amygdala: a role for NMDA receptors.
Topics: Amygdala; Analysis of Variance; Anesthetics; Animals; Animals, Newborn; Dose-Response Relationship, Drug; Drug Interactions; Electric Stimulation; Excitatory Amino Acid Antagonists; GABA Antagonists; gamma-Aminobutyric Acid; In Vitro Techniques; Inhibitory Postsynaptic Potentials; Male; Membrane Potentials; Neurons; Patch-Clamp Techniques; Picrotoxin; Pregnanolone; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Synaptic Transmission | 2007 |
Interaction of diazepam and swim stress.
Topics: Analysis of Variance; Animals; Anticonvulsants; Behavior, Animal; Diazepam; Dose-Response Relationship, Drug; Drug Combinations; Mice; Picrotoxin; Pregnanolone; Reaction Time; Seizures; Stress, Psychological; Swimming | 2007 |
Involvement of neurosteroids in the anxiolytic-like effects of AC-5216 in mice.
Topics: Animals; Anti-Anxiety Agents; Diazepam; Dihydrotestosterone; Dose-Response Relationship, Drug; Enzyme Inhibitors; Finasteride; GABA Antagonists; Interpersonal Relations; Male; Mice; Picrotoxin; Pregnanolone; Progesterone; Purines; Receptors, GABA-A | 2008 |
Investigation of the anticonvulsive effect of acute immobilization stress in anxious Balb/cByJ mice using GABA A-related mechanistic probes.
Topics: Allosteric Regulation; Animals; Anxiety; Bridged Bicyclo Compounds, Heterocyclic; Clonazepam; Convulsants; Drug Interactions; Finasteride; Isoquinolines; Male; Mice; Mice, Inbred BALB C; Oxazines; Picrotoxin; Pregnanolone; Progesterone; Receptors, GABA-A; Restraint, Physical; Seizures; Stress, Psychological | 2008 |
Allopregnanolone-induced rise in intracellular calcium in embryonic hippocampal neurons parallels their proliferative potential.
Topics: Anesthetics; Animals; Bicuculline; Calcium; Calcium Channel Blockers; Calcium Channels, L-Type; Cell Proliferation; Cells, Cultured; Cytoplasm; Female; GABA Antagonists; Hippocampus; Neurons; Nifedipine; Picrotoxin; Pregnancy; Pregnanolone; Rats; Rats, Sprague-Dawley; Review Literature as Topic | 2008 |
Possible GABAergic modulation in the protective effect of allopregnanolone on sleep deprivation-induced anxiety-like behavior and oxidative damage in mice.
Topics: Animals; Anxiety; Behavior, Animal; Body Weight; Catalase; Dose-Response Relationship, Drug; Flumazenil; GABA Agonists; GABA Antagonists; GABA Modulators; Glutathione; Lipid Peroxidation; Male; Maze Learning; Mice; Motor Activity; Muscimol; Neuroprotective Agents; Nitrites; Oxidative Stress; Picrotoxin; Pregnanolone; Sleep Deprivation | 2008 |
Allopregnanolone, the active metabolite of progesterone protects against neuronal damage in picrotoxin-induced seizure model in mice.
Topics: Animals; Convulsants; Disease Models, Animal; Electrophoresis, Agar Gel; Enzyme Inhibitors; Finasteride; Indomethacin; Male; Mice; Neurons; Picrotoxin; Pregnanolone; Seizures | 2010 |
Investigation of the mechanisms of progesterone protection following oxygen-glucose deprivation in organotypic hippocampal slice cultures.
Topics: 5-alpha Reductase Inhibitors; Analysis of Variance; Animals; Animals, Newborn; Cell Death; Dose-Response Relationship, Drug; Finasteride; GABA Antagonists; Glucose; Hippocampus; Hypoxia; Mice; Mice, Inbred C57BL; Neuroprotective Agents; Organ Culture Techniques; Picrotoxin; Pregnanolone; Progesterone; Propidium | 2012 |
Tetramethylenedisulfotetramine alters Ca²⁺ dynamics in cultured hippocampal neurons: mitigation by NMDA receptor blockade and GABA(A) receptor-positive modulation.
Topics: Action Potentials; Animals; Animals, Newborn; Anticonvulsants; Bicuculline; Bridged-Ring Compounds; Calcium Channel Blockers; Calcium Signaling; Cells, Cultured; Convulsants; Diazepam; Dizocilpine Maleate; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; GABA-A Receptor Antagonists; High-Throughput Screening Assays; Hippocampus; Mice; Mice, Inbred C57BL; Microelectrodes; Neurons; Picrotoxin; Pregnanolone; Receptors, GABA-A; Receptors, N-Methyl-D-Aspartate; Spectrometry, Fluorescence; Time Factors | 2012 |
Bicuculline- and neurosteroid-sensitive tonic chloride current in rat hypoglossal motoneurons and atypical dual effect of SR95531.
Topics: Action Potentials; Animals; Bicuculline; Brain Stem; GABA-A Receptor Agonists; GABA-A Receptor Antagonists; Motor Neurons; Picrotoxin; Pregnanolone; Protein Subunits; Pyridazines; Rats; Rats, Sprague-Dawley; Receptors, GABA; Receptors, GABA-A | 2013 |
Neurosteroid Agonist at GABAA receptor induces persistent neuroplasticity in VTA dopamine neurons.
Topics: Action Potentials; Animals; Dopamine; Dopaminergic Neurons; Excitatory Amino Acid Agents; Female; GABA Agents; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Green Fluorescent Proteins; In Vitro Techniques; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Neuronal Plasticity; Neurotransmitter Agents; Picrotoxin; Pregnanolone; Receptors, GABA-A; Ventral Tegmental Area | 2014 |
Allopregnanolone augments epileptiform activity of an in-vitro mouse hippocampal preparation in the first postnatal week.
Topics: Animals; GABA-A Receptor Antagonists; Hippocampus; Membrane Potentials; Mice; Patch-Clamp Techniques; Picrotoxin; Pregnanolone | 2019 |