picrotoxin has been researched along with picrotoxinin in 148 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 53 (35.81) | 18.7374 |
| 1990's | 46 (31.08) | 18.2507 |
| 2000's | 25 (16.89) | 29.6817 |
| 2010's | 21 (14.19) | 24.3611 |
| 2020's | 3 (2.03) | 2.80 |
| Authors | Studies |
|---|---|
| Serratosa, J; Trullas, R; Tusell, JM; Vendrell, M | 1 |
| Betz, H; Bormann, J; Langosch, D; Pribilla, I; Takagi, T | 1 |
| Pencheva, N; Radomirov, R; Venkova, K | 1 |
| Dreher, J; Eshel, G; Jackson, DM; Ong, J; Wong, LS | 1 |
| Sastry, BR; Xie, Z | 1 |
| Morishita, W; Sastry, BR | 3 |
| Bowman, JW; Lee, BL; Thompson, DP; Whaley, HA | 1 |
| Bloomquist, JR; Grubs, RE; Knipple, DC; Soderlund, DM | 1 |
| Artigas, F; de Vera, N; Martínez, E | 1 |
| Isenberg, KE; Yang, J; Zorumski, CF | 1 |
| McIntyre, T; Skolnick, P | 1 |
| Capper, HR; Johnston, GA; Kerr, DI; Ong, J | 1 |
| Fincher, AS; Frye, GD; Griffith, WH; Lorenzetti, M; Trzeciakowski, J | 1 |
| Matsumura, F | 1 |
| Gee, KW; Lawrence, LJ; Yamamura, HI | 1 |
| Fukuda, H; Matsumoto, K; Ono, H; Yamazaki, J | 1 |
| Aguilar-Veiga, E; Galan-Valiente, J; Mendez-Alvarez, E; Sierra-Marcuño, G; Sierra-Paredes, G; Soto-Otero, R | 1 |
| Crema, A; De Petris, G; Manzo, L; Onori, L; Rizzi, CA; Tonini, M | 1 |
| Miller, LG; Roy, RB; Weill, CL | 1 |
| Candura, SM; Crema, A; Frigo, GM; Manzo, L; Onori, L; Rizzi, CA; Tonini, M | 1 |
| Chang, YF; Gao, XM | 1 |
| Bhadra, S; Idemudia, SO; Lal, H | 1 |
| Kirkness, EF; Turner, AJ | 1 |
| Seifert, J | 1 |
| Peterfreund, RA; Vale, WW | 2 |
| Bender, AS; Hertz, L | 1 |
| Dichter, MA; Snodgrass, SR; White, WF | 1 |
| Chow, SC; Johnston, GA; MacDonald, RL; Prager, RH; Skerritt, JH; Ward, AD | 1 |
| Chweh, AY; Swinyard, EA; Ulloque, RA; Wolf, HH | 1 |
| Bülthoff, H; Bülthoff, I | 1 |
| Johnston, GA; Kerr, DI; Ong, J | 1 |
| Covey, DF; Ferrendelli, JA; Levine, JA; Naritoku, DK | 1 |
| Ong, J | 1 |
| Drexler, G; Sieghart, W | 1 |
| Lenschow, V; Lohse, MJ; Schwabe, U | 1 |
| Leeb-Lundberg, LM; Olsen, RW; Snowman, AM; Wong, EH | 1 |
| Kerr, DI; Ong, J | 2 |
| Bokisch, AJ; Bold, JM; Gardner, CR; Perkins, MN; Roberts, CJ; Stone, TW; Walker, RJ | 1 |
| Kamp, CW; Morgan, WW | 1 |
| Collins, JF; James, VA; Roberts, CJ; Walker, RJ | 1 |
| Burch, TP; Davis, WC; Ticku, MK | 1 |
| Ghiasuddin, SM; Matsumura, F | 1 |
| Casida, JE; Lawrence, LJ | 1 |
| Olsen, RW | 1 |
| Burch, TP; Davis, W; Ticku, MK | 1 |
| Davis, WC; Ticku, MK | 1 |
| Kerr, DI; Krantis, A | 1 |
| Fukuda, H; Matsumoto, K | 1 |
| Covey, DF; Ferrendelli, JA; Kalman, BL; Klunk, WE | 1 |
| Johnston, GA; Willow, M | 1 |
| Casida, JE; Gammon, D | 1 |
| Olsen, RW; Stephenson, FA | 1 |
| Burch, TP; Ramanjaneyulu, R; Thyagarajan, R; Ticku, MK | 1 |
| Braestrup, C; Honoré, T; Nielsen, M | 1 |
| Ramanjaneyulu, R; Ticku, MK | 2 |
| Sarhan, S; Seiler, N | 1 |
| Fillenz, M; Fung, SC | 1 |
| Kudo, Y; Niwa, H; Tanaka, A; Yamada, K | 1 |
| Leeb-Lundberg, F; Olsen, RW; Snowman, A | 1 |
| Pokras, R; Tabakoff, B | 1 |
| Casida, JE; Gammon, DW; Lawrence, LJ | 1 |
| Hess, GP; Walstrom, KM | 1 |
| Bormann, J; Feigenspan, A | 1 |
| Bormann, J; Enz, R | 1 |
| Baylis, HA; Buckingham, SD; Hosie, AM; Sattelle, DB | 1 |
| Baylis, HA; Buckingham, SD; Holyoke, CW; Hosie, AM; Sattelle, DB; Shirai, Y | 1 |
| Bormann, J; Feigenspan, A; Wässle, H | 1 |
| Candura, SM; Coccini, T; Costa, LG; Manzo, L; Tonini, M | 1 |
| Barry, PH; Lynch, JW; Rajendra, S; Schofield, PR | 1 |
| Basile, AS; Drugan, RC; Ferland, RJ; Ha, JH | 1 |
| Anthony, NM; Holyoke, CW; Sattelle, DB | 1 |
| Pomés, A; Rodríguez-Farré, E; Suñol, C | 1 |
| Bormann, J; Schönrock, B | 1 |
| Betz, H; Taleb, O | 1 |
| Pencheva, N; Radomirov, R | 1 |
| Chalmers, AE; Ffrench-Constant, RH; Rocheleau, TA; Steichen, JC | 1 |
| Borst, A; Egelhaaf, M; Warzecha, AK | 1 |
| Fujisaki, H; Hamaguchi, T; Ishii, Y; Kaneko, H; Oguri, K; Yamada, H | 1 |
| Brideau, AD; Lipton, SA; Pan, ZH; Zhang, D; Zhang, X | 1 |
| Fiszer de Plazas, S; Mitridate de Novara, A; Viapiano, MS | 1 |
| Camón, L; de Vera, N; Giménez-Llort, L; Martínez, E | 1 |
| Cross, AJ; Green, AR; Misra, A; Murray, TK; Snape, MF | 1 |
| Buckingham, SD; Rauh, J; Sattelle, DB; Schnee, M | 1 |
| Greka, A; Koolen, JA; Lipton, SA; Zhang, D | 1 |
| Banke, T; Elster, L; Kristiansen, U; Schousboe, A; Wahl, P | 1 |
| Fuse, T; Wotring, VE; Yoon, KW | 1 |
| Barbier, EL; Dedousis, N; Fernstrom, JD; Forman, SD; Koretsky, AP; Silva, AC | 1 |
| Lees, G; Nicholson, RA; Verdon, B; Zheng, J | 1 |
| Akagi, H; Hosie, AM; Ishida, M; Shinozaki, H | 1 |
| Carr, RL; Chambers, JE; Coats, JR; Couch, TA; Liu, J | 1 |
| Honda, H; Ikeda, T; Nagata, K; Narahashi, T; Okuyama, E; Ozoe, Y; Shono, T | 1 |
| Fiszer de Plazas, S; Mitridate de Novara, AM; Rodríguez Gil, DJ; Viapiano, MS | 1 |
| Bregestovski, PD; Zhorov, BS | 1 |
| Ishima, Y; Kondo, S; Sugiura, T; Waku, K; Yoshinaga, N | 1 |
| Bracamontes, J; Covey, DF; Steinbach, JH; Yu, L; Zhang, P | 1 |
| Feigenspan, A; Gustincich, S; Raviola, E | 1 |
| Korpi, ER; Lüddens, H; Panula, P; Särkioja, T; Sinkkonen, ST; Tiihonen, J; Tupala, E; Uusi-Oukari, M | 1 |
| Ikeda, T; Kono, Y; Nagata, K; Narahashi, T; Shono, T; Yeh, JZ; Zhao, X | 1 |
| Horoszok, L; Raymond, V; Sattelle, DB; Wolstenholme, AJ | 1 |
| Flores-Herr, N; Protti, DA; Wässle, H | 1 |
| Baufreton, J; Bioulac, B; Dovero, S; Dufy, B; Garret, M; Taupignon, A | 1 |
| Artigas, F; Celada, P; Martín-Ruiz, R; Mengod, G; Puig, MV; Roth, BL; Shapiro, DA | 1 |
| Chebib, M; Duke, RK; Huang, SH; Johnston, GA; Sasaki, K; Wada, K | 2 |
| Cully, DF; Ludmerer, SW; Priest, B; Zheng, Y | 1 |
| Eisenman, LN; Fields, C; He, Y; Mennerick, S; Zorumski, CF | 1 |
| HENSEN, EJ; JERSLEV, B | 1 |
| Fishkin, N; Ivic, L; Kriegstein, AR; Nakanishi, K; Sands, TT; Strømgaard, K | 1 |
| SLATER, SN; WILSON, AT | 1 |
| Behrens, M; Brockhoff, A; Bufe, B; Kuhn, C; Meyerhof, W; Winnig, M | 1 |
| Diamond, JS | 1 |
| Eguchi, Y; Fushiki, S; Hamasaki, Y; Ihara, M; Matsuda, K; Niwa, H; Ochi, E; Ozoe, F; Ozoe, Y; Shibata, Y; Sugama, H; Wada, M | 1 |
| Amin, J; Hadley, SH | 1 |
| Buckinx, R; Lecorronc, H; Legendre, P; Mangin, JM; Rigo, JM; Wang, DS | 1 |
| Hao, YL; Ju, XL; Ozoe, Y; Pei, JF | 1 |
| Cromer, BA; Harvey, RJ; Lynch, JW; Parker, MW; Yang, Z | 1 |
| Carland, JE; Chebib, M; Johnston, GA | 1 |
| Eguchi, Y; Hirata, K; Ishida, C; Matsuda, K; Ozoe, F; Ozoe, Y; Sakai, K | 1 |
| Chen, X; Cromer, B; Hantke, J; Harvey, RJ; Lynch, JW; Parker, MW; Webb, TI; Yang, Z | 1 |
| Akk, G; Bracamontes, J; Khatri, A; Li, P; Steinbach, JH; Weiss, DS | 1 |
| Babai, N; Luo, J; Margalit, E; Thoreson, WB | 1 |
| Duke, RK; Lummis, SC; Thompson, AJ | 1 |
| Alqazzaz, M; Breitinger, HG; Lummis, SC; Price, KL; Thompson, AJ | 1 |
| Mehrotra, S; Rawat, B; Rawat, JM | 1 |
| Jochems, A; Knauer, B; Valero-Aracama, MJ; Yoshida, M | 1 |
| Copenhaver, PF; Ramaker, JM; Swanson, TL | 1 |
| Chen, L; Guo, Y; Han, LN; Hui, YP; Li, LB; Liu, J; Sun, YN; Wang, Y; Zhang, L; Zhang, QJ | 1 |
| Fei, Z; Jia, C; Liu, W; Liu, Y; Long, Q; Wang, K; Yang, H; Yi, X | 1 |
| Gassel, M; Ilg, T; Noack, S; Williams, H; Wolf, C | 1 |
| Kirik, D; Kokaia, M; Ledri, M; Madsen, MG; Nikitidou, L | 1 |
| Alqazzaz, M; Lummis, SC; Price, KL; Thompson, AJ; Weston, DA | 1 |
| Huang, Y; Ito, W; Jiao, S; Ko, H; Lu, B; Morozov, A; Wu, JY; Yoon, K; Yung, WH | 1 |
| Biel, M; Hüll, K; Laprell, L; Michalakis, S; Schön, C; Stawski, P; Sumser, MP; Trauner, D | 1 |
| Shenvi, RA | 1 |
| Dong, YX; Gao, CF; Mu, XC; Wang, LX; Wei, Q; Wu, SF | 1 |
| Naffaa, MM; Samad, A | 1 |
| Rossokhin, AV; Zhorov, BS | 1 |
| Duke, RK; Hinton, T; Johnston, GAR; Ng, CC | 1 |
| Cao, X; Gao, TM; Gong, Z; Kuang, XJ; Li, SJ; Lin, MS; Liu, C; Mechawar, N; Xiong, WC; Zhang, Y; Zhu, XH | 1 |
| Behrens, M; Di Pizio, A; Levit, A; Meyerhof, W; Niv, MY; Nowak, S | 1 |
| Burdge, HE; Crossley, SWM; Lambrecht, MJ; Shenvi, RA; Tong, G | 1 |
| Goodchild, J; Lansdell, SJ; Millar, NS; Puinean, AM; Sanders, VR; Smelt, CLC | 1 |
| Shenvi, RA; Tong, G | 1 |
4 review(s) available for picrotoxin and picrotoxinin
| Article | Year |
|---|---|
Interactions of pyrethroid insecticides with chloride ionophore-associated binding sites.
Topics: Animals; Benzodiazepinones; Brain; Brain Chemistry; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Chlorides; Convulsants; Drug Interactions; Guinea Pigs; Ion Channels; Picrotoxin; Pyrethrins; Radioligand Assay; Rats; Receptors, GABA-A; Sesterterpenes | 1985 |
GABA-benzodiazepine-barbiturate receptor interactions.
Topics: Animals; Barbiturates; Benzodiazepines; Brain; gamma-Aminobutyric Acid; Kinetics; Picrotoxin; Receptors, Cell Surface; Receptors, Drug; Receptors, GABA-A; Receptors, Neurotransmitter; Sesterterpenes | 1981 |
Biochemical pharmacology of the GABA receptor-ionophore protein complex.
Topics: Animals; Brain; Chlorides; Flunitrazepam; Humans; Ion Channels; Ionophores; Kinetics; Muscimol; Nerve Tissue Proteins; Picrotoxin; Receptors, Cell Surface; Receptors, GABA-A; Receptors, Neurotransmitter; Sesterterpenes | 1983 |
Neurite outgrowth enhancement by jiadifenolide: possible targets.
Topics: Convulsants; Lactones; Molecular Structure; Neurites; Picrotoxin; Sesquiterpenes; Sesterterpenes; Spiro Compounds | 2016 |
144 other study(ies) available for picrotoxin and picrotoxinin
| Article | Year |
|---|---|
Lindane-induced convulsions in NMRI and OF1 mice: antagonism with (+)MK-801 and voltage-dependent calcium channel blockers.
Topics: Animals; Anticonvulsants; Calcium Channel Blockers; Convulsants; Dizocilpine Maleate; Dose-Response Relationship, Drug; Hexachlorocyclohexane; Male; Mice; Mice, Inbred Strains; N-Methylaspartate; Nifedipine; Pentylenetetrazole; Picrotoxin; Seizures; Sesterterpenes; Species Specificity | 1992 |
The atypical M2 segment of the beta subunit confers picrotoxinin resistance to inhibitory glycine receptor channels.
Topics: Amino Acid Sequence; Animals; Base Sequence; Cell Line; Cells, Cultured; Cerebellum; Cloning, Molecular; DNA; Glycine; Humans; Ion Channels; Molecular Sequence Data; Mutagenesis, Site-Directed; Picrotoxin; Rats; Receptors, Glycine; Receptors, Neurotransmitter; Sequence Homology, Amino Acid; Sesterterpenes; Spinal Cord; Strychnine | 1992 |
GABAA and GABAB receptor-mediated effects on the spontaneous activity of the longitudinal layer in cat terminal ileum.
Topics: Animals; Baclofen; Bicuculline; Cats; GABA Antagonists; gamma-Aminobutyric Acid; Gastrointestinal Motility; Ileum; In Vitro Techniques; Male; Muscimol; Muscle Contraction; Picrotoxin; Receptors, GABA-A; Sesterterpenes; Tetrodotoxin | 1991 |
Role of dopamine and GABA in the control of motor activity elicited from the rat nucleus accumbens.
Topics: Animals; Baclofen; Dopamine; Dopamine Antagonists; GABA Antagonists; gamma-Aminobutyric Acid; Male; Motor Activity; Nucleus Accumbens; Picrotoxin; Rats; Rats, Inbred Strains; Receptors, Dopamine; Receptors, GABA-A; Sesterterpenes; Taurine | 1991 |
Inhibition of protein kinase activity enhances long-term potentiation of hippocampal IPSPs.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Acetates; Acetic Acid; Animals; Baclofen; Carbazoles; Evoked Potentials; Guinea Pigs; Hippocampus; In Vitro Techniques; Indole Alkaloids; Neurons; Picrotoxin; Potentiometry; Protein Kinase C; Pyramidal Tracts; Quinoxalines; Sesterterpenes | 1991 |
Chelation of postsynaptic Ca2+ facilitates long-term potentiation of hippocampal IPSPs.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Calcium; Egtazic Acid; Guinea Pigs; Hippocampus; Membrane Potentials; Memory; Picrotoxin; Quinoxalines; Receptors, GABA-A; Sesterterpenes | 1991 |
Effects of dihydroavermectin B1a and analogs on stretcher muscle of the lined shore crab, Pachygrapsus crassipes.
Topics: Animals; Anthelmintics; Bicuculline; Brachyura; Caenorhabditis; Chlorides; Cobalt; Dose-Response Relationship, Drug; Drug Interactions; gamma-Aminobutyric Acid; In Vitro Techniques; Ivermectin; Membrane Potentials; Membranes; Motor Endplate; Muscimol; Muscles; Picrotoxin; Sesterterpenes; Structure-Activity Relationship; Synapses; Time Factors | 1991 |
Prolonged exposure to GABA activates GABA-gated chloride channels in the presence of channel-blocking convulsants.
Topics: Animals; Brain; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Chloride Channels; Chlorides; Convulsants; Endrin; GABA Antagonists; gamma-Aminobutyric Acid; Ion Channel Gating; Kinetics; Male; Membrane Proteins; Mice; Mice, Inbred ICR; Picrotoxin; Rats; Rats, Inbred Strains; Receptors, GABA-A; Sesterterpenes; Xenopus | 1991 |
Differential response of rat brain polyamines to convulsant agents.
Topics: Animals; Biogenic Polyamines; Body Weight; Brain; Convulsants; Hexachlorocyclohexane; Kainic Acid; Male; Ornithine Decarboxylase; Pentylenetetrazole; Picrotoxin; Putrescine; Rats; Rats, Inbred Strains; Sesterterpenes; Spermidine; Spermine | 1991 |
Volatile anesthetics gate a chloride current in postnatal rat hippocampal neurons.
Topics: 4-Acetamido-4'-isothiocyanatostilbene-2,2'-disulfonic Acid; 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; Anesthetics; Animals; Animals, Newborn; Bicuculline; Chlorine; Chromatography, Gas; Culture Techniques; Dose-Response Relationship, Drug; Electrophysiology; Enflurane; gamma-Aminobutyric Acid; Halothane; Hippocampus; Ion Channel Gating; Isoflurane; Neurons; Picrotoxin; Rats; Sesterterpenes; Strychnine | 1992 |
t-[35S]butylbicyclophosphorothionate binding under equilibrium and nonequilibrium conditions: differential effects of barbiturates and gamma-aminobutyric acid in the long-sleep and short-sleep selected mouse lines.
Topics: Animals; Barbiturates; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Cell Membrane; Cerebellum; Cerebral Cortex; Chloride Channels; Ethanol; gamma-Aminobutyric Acid; Kinetics; Male; Membrane Proteins; Mice; Pentobarbital; Phenobarbital; Picrotoxin; Receptors, GABA-A; Sesterterpenes; Sleep | 1991 |
Cortisone: a potent GABAA antagonist in the guinea-pig isolated ileum.
Topics: Androstanes; Animals; Azasteroids; Cortisone; Female; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Guinea Pigs; Hydrocortisone; Ileum; In Vitro Techniques; Male; Models, Molecular; Muscle Contraction; Muscle, Smooth; Picrotoxin; Sesterterpenes | 1990 |
Comparison of contractile responses of the guinea pig ileum longitudinal muscle to ethanol and GABAA agonists.
Topics: Animals; Atropine; Bicuculline; Chlorides; Ethanol; Female; Guinea Pigs; Ileum; In Vitro Techniques; Male; Muscimol; Muscle Contraction; Pentobarbital; Picrotoxin; Receptors, GABA-A; Sesterterpenes; Taurine; Tetrodotoxin | 1990 |
Involvement of picrotoxinin receptor in the action of cyclodiene insecticides.
Topics: Animals; Cockroaches; Dieldrin; Hexachlorocyclohexane; In Vitro Techniques; Insecticides; Nervous System; Picrotoxin; Receptors, GABA-A; Sesterterpenes; Species Specificity | 1985 |
Macrolide compounds, ivermectin and milbemycin D, stimulate chloride channels sensitive to GABAergic drugs in cultured chick spinal neurons.
Topics: Animals; Anti-Bacterial Agents; Bicuculline; Cells, Cultured; Chick Embryo; Chlorides; Diazepam; gamma-Aminobutyric Acid; Ion Channels; Ivermectin; Lactones; Macrolides; Membrane Potentials; Muscimol; Neurons; Picrotoxin; Sesterterpenes; Spinal Cord | 1989 |
Simultaneous determination of the two components of picrotoxin in serum by reversed-phase high-performance liquid chromatography with application to a pharmacokinetic study in rats.
Topics: Animals; Chromatography, High Pressure Liquid; Injections, Intraperitoneal; Male; Picrotoxin; Rats; Rats, Inbred Strains; Reference Standards; Sesterterpenes | 1989 |
The role of GABAA receptor function in peristaltic activity of the guinea-pig ileum: a comparative study with bicuculline, SR 95531 and picrotoxinin.
Topics: Animals; Bicuculline; Electric Stimulation; GABA Antagonists; Gastrointestinal Motility; Guinea Pigs; Ileum; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Myenteric Plexus; Peristalsis; Picrotoxin; Pyridazines; Receptors, GABA-A; Sesterterpenes | 1989 |
Chronic clonazepam administration decreases gamma-aminobutyric acidA receptor function in cultured cortical neurons.
Topics: Animals; Benzodiazepines; Cells, Cultured; Cerebral Cortex; Chick Embryo; Chlorides; Clonazepam; Drug Administration Schedule; Flumazenil; Muscimol; Picrotoxin; Receptors, GABA-A; Sesterterpenes | 1989 |
An in vitro study of the relationship between GABA receptor function and propulsive motility in the distal colon of the rabbit.
Topics: Amino Acids; Amino Acids, Neutral; Animals; Autonomic Nervous System; Baclofen; Colon; gamma-Aminobutyric Acid; Gastrointestinal Motility; In Vitro Techniques; Male; Muscle Relaxation; Muscle, Smooth; Picrotoxin; Rabbits; Receptors, GABA-A; Sesterterpenes; Taurine | 1989 |
Enhancement of benzodiazepine receptor binding by L-lysine is chloride-dependent and due to increase in binding affinity.
Topics: Animals; Cattle; Chlorides; Flunitrazepam; In Vitro Techniques; Kinetics; Lysine; Pentylenetetrazole; Picrotoxin; Receptors, GABA-A; Sesterterpenes; Synaptic Membranes | 1989 |
The pentylenetetrazol-like interoceptive stimulus produced by ethanol withdrawal is potentiated by bicuculline and picrotoxinin.
Topics: Animals; Anxiety; Bicuculline; Discrimination Learning; Dose-Response Relationship, Drug; Ethanol; GABA Antagonists; Male; Pentylenetetrazole; Picrotoxin; Rats; Seizures; Sesterterpenes; Substance Withdrawal Syndrome | 1989 |
The stimulatory effects of secobarbital and pregnanolone on the GABAA receptor can be blocked selectively.
Topics: Animals; Anthelmintics; Cerebral Cortex; In Vitro Techniques; Ivermectin; Muscimol; Phenobarbital; Picrotoxin; Pregnanes; Pregnanolone; Radioligand Assay; Receptors, GABA-A; Secobarbital; Sesterterpenes; Swine; Synaptic Membranes | 1988 |
Ontogenesis and properties of the convulsant recognition site(s) of the gamma-aminobutyric acid (GABA) receptor complex in chicken embryo.
Topics: Aging; Animals; Brain Chemistry; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Chick Embryo; Convulsants; Endrin; Kinetics; Membranes; Picrotoxin; Receptors, GABA-A; Sesterterpenes | 1988 |
Somatostatin secretion from the hypothalamus.
Topics: Animals; Carbachol; Cells, Cultured; Cerebral Cortex; gamma-Aminobutyric Acid; Hypothalamus; Immunologic Techniques; Membrane Potentials; Muscimol; Norepinephrine; Picrotoxin; Potassium; Rats; Secretory Rate; Sesterterpenes; Somatostatin; Tetradecanoylphorbol Acetate | 1985 |
Evidence for involvement of the astrocytic benzodiazepine receptor in the mechanism of action of convulsant and anticonvulsant drugs.
Topics: Animals; Anticonvulsants; Astrocytes; Barbiturates; Benzodiazepinones; Brain; Carbamazepine; Cells, Cultured; Convulsants; Diazepam; Ethosuximide; Mice; Neurons; Pentylenetetrazole; Phenobarbital; Picrotoxin; Receptors, GABA-A; Sesterterpenes; Trimethadione; Valproic Acid | 1988 |
The picrotoxinin binding site and its relationship to the GABA receptor complex.
Topics: Acetates; Acetic Acid; Animals; Brain; Chlorides; Diazepam; Dose-Response Relationship, Drug; gamma-Aminobutyric Acid; Picrotoxin; Rats; Receptors, GABA-A; Sesterterpenes; Sodium | 1985 |
Differential modulation of gamma-aminobutyric acid receptors by caprolactam derivatives with central nervous system depressant or convulsant activity.
Topics: Animals; Azepines; Caprolactam; Central Nervous System; Central Nervous System Depressants; Convulsants; Male; Muscle Relaxants, Central; Pentobarbital; Picrotoxin; Rats; Rats, Inbred Strains; Receptors, GABA-A; Sesterterpenes; Structure-Activity Relationship | 1985 |
Effect of picrotoxinin on benzodiazepine receptor binding.
Topics: Animals; Brain; Cerebellum; Flunitrazepam; gamma-Aminobutyric Acid; In Vitro Techniques; Kinetics; Male; Membranes; Mice; Pentobarbital; Picrotoxin; Receptors, GABA-A; Sesterterpenes | 1985 |
GABA-antagonist inverts movement and object detection in flies.
Topics: Action Potentials; Animals; Brain; Diptera; Drosophila melanogaster; Motion Perception; Neurons; Photic Stimulation; Picrotoxin; Sesterterpenes; Visual Perception | 1987 |
Alfaxalone potentiates and mimics GABA-induced contractile responses in the guinea-pig isolated ileum.
Topics: Anesthetics; Animals; Bicuculline; Female; gamma-Aminobutyric Acid; Guinea Pigs; Ileum; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Picrotoxin; Pregnanediones; Sesterterpenes | 1988 |
Effects of anticonvulsant and convulsant gamma-butyrolactones and thiobutyrolactones on GABA-mediated chloride uptake.
Topics: 4-Butyrolactone; Animals; Anticonvulsants; Cerebral Cortex; Chlorides; Convulsants; Female; Furans; gamma-Aminobutyric Acid; Pentobarbital; Picrotoxin; Rats; Rats, Inbred Strains; Sesterterpenes; Structure-Activity Relationship | 1987 |
Uptake inhibitors potentiate gamma-aminobutyric acid-induced contractile responses in the isolated ileum of the guinea-pig.
Topics: Animals; Bicuculline; Female; gamma-Aminobutyric Acid; Guinea Pigs; Ileum; In Vitro Techniques; Male; Muscimol; Muscle Contraction; Muscle, Smooth; Picrotoxin; Sesterterpenes; Taurine | 1987 |
Evidence for association of a high affinity avermectin binding site with the benzodiazepine receptor.
Topics: Animals; Binding Sites; Binding, Competitive; Cell Membrane; Cerebellar Cortex; Chlorides; Flunitrazepam; In Vitro Techniques; Ivermectin; Lactones; Picrotoxin; Rats; Receptors, Cell Surface; Receptors, GABA-A; Sesterterpenes; Temperature | 1984 |
Interaction of barbiturates with adenosine receptors in rat brain.
Topics: Adenosine; Animals; Barbiturates; Binding, Competitive; Brain Chemistry; Drug Interactions; Guanosine Triphosphate; In Vitro Techniques; Kinetics; Male; Phenylisopropyladenosine; Picrotoxin; Rats; Rats, Inbred Strains; Receptors, Cell Surface; Receptors, Purinergic; Sesterterpenes; Synaptosomes; Xanthines | 1984 |
Barbiturates allosterically inhibit GABA antagonist and benzodiazepine inverse agonist binding.
Topics: Allosteric Regulation; Animals; Barbiturates; Benzodiazepines; Bicuculline; Binding, Competitive; Carbolines; Etazolate; GABA Antagonists; In Vitro Techniques; Kinetics; Picrotoxin; Rats; Receptors, GABA-A; Sesterterpenes; Stereoisomerism | 1984 |
Potentiation of GABAA-receptor-mediated responses by barbiturates in the guinea-pig ileum.
Topics: Animals; Barbiturates; Bicuculline; Drug Interactions; Female; Guinea Pigs; Ileum; In Vitro Techniques; Male; Muscle Contraction; Muscle Relaxation; Muscle, Smooth; Pentobarbital; Picrotoxin; Receptors, GABA-A; Sesterterpenes | 1984 |
The action of gamma-aminobutyric acid (GABA) and ethylenediamine (EDA) on Limulus and Helix central neurones and rat cerebellar and sympathetic ganglion neurones.
Topics: Animals; Cerebellum; Ethylenediamines; Female; Flurazepam; gamma-Aminobutyric Acid; Ganglia, Sympathetic; Helix, Snails; Horseshoe Crabs; Neurons; Picrotoxin; Purkinje Cells; Rats; Rats, Inbred Strains; Receptors, GABA-A; Sesterterpenes | 1984 |
Some barbiturates enhance the effect of muscimol on dopamine turnover in the rat retina.
Topics: Animals; Barbital; Barbiturates; Convulsants; Dopamine; Drug Synergism; GABA Antagonists; gamma-Aminobutyric Acid; Light; Male; Methyltyrosines; Muscimol; Oxazoles; Pentobarbital; Phenobarbital; Picrotoxin; Rats; Retina; Sesterterpenes | 1980 |
The action of seven convulsants as antagonists of the GABA response of Limulus neurons.
Topics: Animals; Aza Compounds; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Bridged-Ring Compounds; Convulsants; GABA Antagonists; Horseshoe Crabs; In Vitro Techniques; Membrane Potentials; Neurons; Organophosphorus Compounds; Picrotoxin; Sesterterpenes | 1981 |
The interactions of ethanol with the benzodiazepine-GABA receptor-ionophore complex.
Topics: Animals; Anti-Anxiety Agents; Benzodiazepines; Brain; Ethanol; gamma-Aminobutyric Acid; Mice; Mice, Inbred Strains; Picrotoxin; Rats; Rats, Inbred Strains; Receptors, Cell Surface; Receptors, GABA-A; Sesterterpenes; Synaptic Membranes; Synaptic Transmission | 1983 |
Evidence for similarities between cyclodiene type insecticides and picrotoxinin in their action mechanisms.
Topics: Animals; Binding, Competitive; Chlorides; Cockroaches; Drug Resistance; gamma-Aminobutyric Acid; Heptachlor; Heptachlor Epoxide; Hexachlorocyclohexane; Male; Muscles; Periplaneta; Picrotoxin; Rats; Receptors, Cell Surface; Receptors, GABA-A; Sesterterpenes; Synaptosomes | 1983 |
Interactions of lindane, toxaphene and cyclodienes with brain-specific t-butylbicyclophosphorothionate receptor.
Topics: Animals; Binding, Competitive; Brain; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Cycloparaffins; Endrin; Hexachlorocyclohexane; Insecticides; Isomerism; Kinetics; Microsomes; NADP; Picrotoxin; Rats; Receptors, Cell Surface; Receptors, GABA-A; Sesterterpenes; Synaptic Membranes; Toxaphene | 1984 |
Interaction of depressant and convulsant drugs with the picrotoxinin binding sites in membranes and solubilized forms.
Topics: Animals; Barbiturates; Binding Sites; Brain; Central Nervous System Depressants; Convulsants; In Vitro Techniques; Membranes; Nerve Tissue Proteins; Picrotoxin; Rats; Receptors, Cell Surface; Receptors, GABA-A; Sesterterpenes | 1981 |
Picrotoxinin and diazepam bind to two distinct proteins: further evidence that pentobarbital may act at the picrotoxinin site.
Topics: Animals; Brain; Cell Membrane; Diazepam; Kinetics; Male; Molecular Weight; Pentobarbital; Picrotoxin; Rats; Rats, Inbred Strains; Receptors, Drug; Receptors, GABA-A; Sesterterpenes | 1981 |
Gaba induced excitatory responses in the guinea-pig small intestine are antagonized by bicuculline, picrotoxinin and chloride ion blockers.
Topics: Animals; Bicuculline; Chlorides; Diuretics; Female; Furosemide; GABA Antagonists; gamma-Aminobutyric Acid; Guinea Pigs; Ileum; In Vitro Techniques; Ion Channels; Male; Muscle Contraction; Myenteric Plexus; Picrotoxin; Sesterterpenes; Sulfonamides | 1981 |
Anisatin modulation of GABA- and pentobarbital-induced enhancement of diazepam binding in rat brain.
Topics: Animals; Brain; Diazepam; Dose-Response Relationship, Drug; gamma-Aminobutyric Acid; Lactones; Male; Neurotoxins; Pentobarbital; Picrotoxin; Rats; Rats, Inbred Strains; Receptors, Cell Surface; Receptors, Drug; Receptors, GABA-A; Sesquiterpenes; Sesterterpenes; Spiro Compounds | 1982 |
Computer-assisted modeling of the picrotoxinin and gamma-butyrolactone receptor site.
Topics: 4-Butyrolactone; Chlorides; Computers; Furans; Ion Channels; Models, Chemical; Picrotoxin; Receptors, Cell Surface; Receptors, GABA-A; Sesterterpenes | 1983 |
Enhancement of GABA binding by pentobarbitone.
Topics: Animals; Brain; Cell Membrane; gamma-Aminobutyric Acid; Pentobarbital; Picrotoxin; Rats; Receptors, Cell Surface; Receptors, GABA-A; Sesterterpenes; Synaptosomes | 1980 |
Pyrethroids of the most potent class antagonize GABA action at the crayfish neuromuscular junction.
Topics: Animals; Astacoidea; Clonazepam; Diazepam; GABA Antagonists; gamma-Aminobutyric Acid; Membrane Potentials; Neuromuscular Junction; Picrotoxin; Pyrethrins; Receptors, Cell Surface; Receptors, GABA-A; Sesterterpenes; Synaptic Transmission | 1983 |
Barbiturate interactions with benzodiazepine-GABA receptor-ionophore complex.
Topics: Animals; Barbiturates; Etomidate; In Vitro Techniques; Ionophores; Muscimol; Pentobarbital; Picrotoxin; Rats; Receptors, Cell Surface; Receptors, GABA-A; Sesterterpenes | 1983 |
Binding of 3H-DMCM to benzodiazepine receptors; chloride dependent allosteric regulation mechanisms.
Topics: Animals; Anions; Carbolines; Cerebral Cortex; Chlorides; Etomidate; Indoles; Molecular Conformation; Pentobarbital; Picrotoxin; Rats; Receptors, Cell Surface; Receptors, GABA-A; Sesterterpenes | 1983 |
Interactions of pentamethylenetetrazole and tetrazole analogues with the picrotoxinin site of the benzodiazepine-GABA receptor-ionophore complex.
Topics: Animals; Azoles; Binding Sites; Brain; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Bridged-Ring Compounds; Drug Interactions; Ionophores; Male; Pentylenetetrazole; Picrotoxin; Rats; Rats, Inbred Strains; Receptors, Cell Surface; Receptors, GABA-A; Sesterterpenes; Tetrazoles | 1984 |
Synergistic anticonvulsant effects of GABA-T inhibitors and glycine.
Topics: 3-Mercaptopropionic Acid; 4-Aminobutyrate Transaminase; Amino Acids; Aminocaproates; Aminooxyacetic Acid; Animals; Anticonvulsants; Bicuculline; Brain Chemistry; Drug Synergism; Ethanolamines; Glycine; Male; Mice; Pentylenetetrazole; Picrotoxin; Rats; Rats, Inbred Strains; Sesterterpenes; Strychnine; Vigabatrin | 1984 |
Evidence for a physiological role of GABA in the control of guinea-pig intestinal motility.
Topics: Animals; Bicuculline; Female; gamma-Aminobutyric Acid; Gastrointestinal Motility; Guinea Pigs; Ileum; Male; Muscle, Smooth; Myenteric Plexus; Picrotoxin; Sesterterpenes; Tachyphylaxis | 1984 |
The actions of barbiturates on release of noradrenaline from rat hippocampal synaptosomes.
Topics: Animals; Barbiturates; gamma-Aminobutyric Acid; Hippocampus; In Vitro Techniques; Male; Norepinephrine; Picrotoxin; Rats; Rats, Inbred Strains; Sesterterpenes; Synaptosomes | 1984 |
Actions of picrotoxinin and related compounds on the frog spinal cord: the role of a hydroxyl-group at the 6-position in antagonizing the actions of amino acids and presynaptic inhibition.
Topics: Action Potentials; Afferent Pathways; Amino Acids; Animals; GABA Antagonists; Hydroxylation; In Vitro Techniques; Neural Inhibition; Picrotoxin; Rana catesbeiana; Reflex; Sesterterpenes; Spinal Cord; Structure-Activity Relationship | 1984 |
Binding characteristics and interactions of depressant drugs with [35S]t-butylbicyclophosphorothionate, a ligand that binds to the picrotoxinin site.
Topics: Animals; Brain; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Bridged-Ring Compounds; Convulsants; Diazepam; Etomidate; gamma-Aminobutyric Acid; Male; Membranes; Pentobarbital; Picrotoxin; Psychotropic Drugs; Rats; Rats, Inbred Strains; Sesterterpenes | 1984 |
Picrotoxinin and phorbol-12-myristate-13-acetate stimulate the secretion of multiple forms of somatostatin from cultured rat brain cells.
Topics: Animals; Cells, Cultured; Chromatography, High Pressure Liquid; Hypothalamus; Peptides; Phorbols; Picrotoxin; Potassium; Rats; Sesterterpenes; Tetradecanoylphorbol Acetate | 1984 |
Perturbation of benzodiazepine receptor binding by pyrazolopyridines involves picrotoxinin/barbiturate receptor sites.
Topics: Animals; Benzodiazepines; Binding Sites; Brain; Etazolate; gamma-Aminobutyric Acid; Phenobarbital; Picrotoxin; Pyrazoles; Rats; Rats, Inbred Strains; Receptors, Drug; Sesterterpenes | 1981 |
On the mechanism by which dopamine inhibits prolactin release in the anterior pituitary.
Topics: Animals; Bicuculline; Chlorpromazine; Depression, Chemical; Dopamine; gamma-Aminobutyric Acid; Haloperidol; Male; Mice; Mice, Inbred C57BL; Muscimol; Picrotoxin; Pituitary Gland, Anterior; Prolactin; Sesterterpenes | 1982 |
Pyrethroid toxicology: protective effects of diazepam and phenobarbital in the mouse and the cockroach.
Topics: Allethrins; Animals; Cockroaches; Diazepam; Male; Motor Neurons; Nitriles; Permethrin; Phenobarbital; Picrotoxin; Pyrethrins; Sesterterpenes; Temperature | 1982 |
Mechanism for the channel-opening reaction of strychnine-sensitive glycine receptors on cultured embryonic mouse spinal cord cells.
Topics: Animals; Cell Membrane; Cells, Cultured; Electric Conductivity; Glycine; Hydrogen-Ion Concentration; Ion Channel Gating; Ion Channels; Mice; Neurons; Picrotoxin; Receptors, Glycine; Sesterterpenes; Spinal Cord; Strychnine | 1994 |
Differential pharmacology of GABAA and GABAC receptors on rat retinal bipolar cells.
Topics: Animals; Bicuculline; Binding Sites; Cells, Cultured; Chickens; Chloride Channels; Dose-Response Relationship, Drug; Flunitrazepam; GABA Antagonists; GABA-A Receptor Antagonists; Hexachlorocyclohexane; Patch-Clamp Techniques; Pentobarbital; Picrotoxin; Pyridazines; Rats; Rats, Wistar; Receptors, GABA; Receptors, GABA-A; Retina; Sesterterpenes; Signal Transduction | 1994 |
A single point mutation decreases picrotoxinin sensitivity of the human GABA receptor rho 1 subunit.
Topics: Base Sequence; Bicuculline; Cell Line; Humans; Molecular Sequence Data; Patch-Clamp Techniques; Peptide Fragments; Picrotoxin; Point Mutation; Proline; Protein Structure, Tertiary; Receptors, GABA; Serine; Sesterterpenes | 1995 |
Actions of the insecticide fipronil, on dieldrin-sensitive and- resistant GABA receptors of Drosophila melanogaster.
Topics: Animals; Dieldrin; Dose-Response Relationship, Drug; Drosophila; gamma-Aminobutyric Acid; Insecticides; Membrane Potentials; Oocytes; Picrotoxin; Pyrazoles; Receptors, GABA; Sesterterpenes | 1995 |
Actions of picrotoxinin analogues on an expressed, homo-oligomeric GABA receptor of Drosophila melanogaster.
Topics: Acetylation; Animals; Drosophila melanogaster; Female; Fluorine; Oocytes; Picrotoxin; Receptors, GABA; Sesterterpenes; Structure-Activity Relationship; Water; Xenopus laevis | 1995 |
Pharmacology of GABA receptor Cl- channels in rat retinal bipolar cells.
Topics: Animals; Animals, Newborn; Bicuculline; Cells, Cultured; Chloride Channels; Flunitrazepam; gamma-Aminobutyric Acid; Ion Channels; Membrane Potentials; Membrane Proteins; Neurons; Pentobarbital; Photoreceptor Cells; Picrotoxin; Pregnanediones; Rats; Receptors, GABA-A; Sesterterpenes; Strychnine | 1993 |
Interaction of the neurotoxic pesticides ivermectin and lindane with the enteric GABAA receptor-ionophore complex in the guinea-pig.
Topics: Animals; Chloride Channels; Female; GABA-A Receptor Antagonists; Guinea Pigs; Hexachlorocyclohexane; In Vitro Techniques; Intestine, Small; Isometric Contraction; Ivermectin; Male; Membrane Proteins; Muscle, Smooth; Picrotoxin; Pyridazines; Receptors, GABA-A; Scopolamine; Sesterterpenes; Taurine; Tetrodotoxin | 1993 |
Mutations affecting the glycine receptor agonist transduction mechanism convert the competitive antagonist, picrotoxin, into an allosteric potentiator.
Topics: Allosteric Regulation; Dose-Response Relationship, Drug; Humans; Mutation; Picrotoxin; Receptors, Glycine; Sesterterpenes; Structure-Activity Relationship | 1995 |
The protective effects of stress control may be mediated by increased brain levels of benzodiazepine receptor agonists.
Topics: Analysis of Variance; Animals; Brain; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Cerebral Cortex; Convulsants; Electroshock; Escape Reaction; Flumazenil; GABA-A Receptor Agonists; Hippocampus; Male; Picrotoxin; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Seizures; Sesterterpenes; Stress, Psychological; Strychnine; Sulfur Radioisotopes; Tritium | 1994 |
Blocking actions of picrotoxinin analogues on insect (Periplaneta americana) GABA receptors.
Topics: Alkaloids; Animals; Central Nervous System Stimulants; Chloride Channels; GABA Antagonists; Ganglia, Invertebrate; Ion Channel Gating; Male; Motor Neurons; Periplaneta; Picrotoxin; Sesterterpenes | 1994 |
Presynaptic actions of GABA and baclofen in CA1 region of the guinea-pig hippocampus in vitro.
Topics: Animals; Baclofen; Bicuculline; Calcium; Electrophysiology; GABA Antagonists; gamma-Aminobutyric Acid; Guinea Pigs; Hippocampus; In Vitro Techniques; Male; Membrane Potentials; Neuromuscular Depolarizing Agents; Organophosphorus Compounds; Picrotoxin; Receptors, Presynaptic; Sesterterpenes; Tetrodotoxin | 1994 |
Disruption of GABA-dependent chloride flux by cyclodienes and hexachlorocyclohexanes in primary cultures of cortical neurons.
Topics: Animals; Calcium; Cells, Cultured; Cerebral Cortex; Chlorides; Endosulfan; Female; gamma-Aminobutyric Acid; Insecticides; Mice; Pentylenetetrazole; Picrotoxin; Pregnancy; Receptors, GABA-A; Sesterterpenes | 1994 |
Activation of Cl- channels by avermectin in rat cultured hippocampal neurons.
Topics: Animals; Animals, Newborn; Anthelmintics; Cells, Cultured; Chloride Channels; Electrophysiology; Hippocampus; Ivermectin; Membrane Potentials; Neurons; Picrotoxin; Rats; Rats, Wistar; Receptors, GABA-A; Sesterterpenes | 1993 |
Expression of the human glycine receptor alpha 1 subunit in Xenopus oocytes: apparent affinities of agonists increase at high receptor density.
Topics: Animals; DNA, Complementary; Female; Glycine; Humans; Peptide Fragments; Picrotoxin; Receptors, Glycine; Recombinant Proteins; Sesterterpenes; Strychnine; Xenopus laevis | 1994 |
Biphasic GABA-A receptor-mediated effect on the spontaneous activity of the circular layer in cat terminal ileum.
Topics: Animals; Atropine; Baclofen; Bicuculline; Cats; gamma-Aminobutyric Acid; Ileum; In Vitro Techniques; Male; Muscimol; Muscle Contraction; Muscle Relaxation; Muscle, Smooth; Picrotoxin; Receptors, GABA-A; Sesterterpenes; Tetrodotoxin | 1993 |
A point mutation in a Drosophila GABA receptor confers insecticide resistance.
Topics: Alanine; Amino Acid Sequence; Animals; Chloride Channels; Dieldrin; DNA Mutational Analysis; Drosophila melanogaster; Electrophysiology; Humans; Insecticide Resistance; Membrane Proteins; Muscimol; Oocytes; Picrotoxin; Point Mutation; Receptors, GABA-A; Serine; Sesterterpenes; Xenopus | 1993 |
Long-term depression of IPSPs in rat deep cerebellar nuclei.
Topics: Animals; Cerebellar Nuclei; Electric Stimulation; Electrophysiology; Evoked Potentials; In Vitro Techniques; Male; Neuronal Plasticity; Picrotoxin; Purkinje Cells; Rats; Rats, Wistar; Sesterterpenes; Synapses; Synaptic Transmission | 1993 |
Neural circuit tuning fly visual interneurons to motion of small objects. I. Dissection of the circuit by pharmacological and photoinactivation techniques.
Topics: Animals; Diptera; Electrophysiology; Female; Fluoresceins; Interneurons; Motion Perception; Neurons; Photic Stimulation; Picrotoxin; Sesterterpenes; Vision, Ocular | 1993 |
Picrotoxin as a potent inducer of rat hepatic cytochrome P450, CYP2B1 and CYP2B2.
Topics: Animals; Cytochrome P-450 Enzyme System; Enzyme Induction; Male; Microsomes, Liver; Oxidoreductases, N-Demethylating; Phenobarbital; Picrotoxin; Rats; Rats, Wistar; Sesterterpenes; Subcellular Fractions; Testosterone; Toxins, Biological | 1993 |
Cloning of a gamma-aminobutyric acid type C receptor subunit in rat retina with a methionine residue critical for picrotoxinin channel block.
Topics: Amino Acid Sequence; Animals; Base Sequence; Chloride Channels; Cloning, Molecular; Dose-Response Relationship, Drug; Drug Resistance; Electric Conductivity; GABA Antagonists; Ion Channels; Methionine; Molecular Sequence Data; Mutagenesis, Site-Directed; Picrotoxin; Protein Conformation; Rats; Receptors, GABA; Retina; Sequence Homology, Amino Acid; Sesterterpenes; Structure-Activity Relationship | 1995 |
Pentobarbital modulatory effect on GABA binding sites in developing chick optic lobe.
Topics: Animals; Bicuculline; Brain; Chick Embryo; GABA Antagonists; GABA Modulators; gamma-Aminobutyric Acid; In Vitro Techniques; Kinetics; Pentobarbital; Picrotoxin; Sesterterpenes; Synaptic Membranes | 1995 |
Concentration of putrescine in plasma, frontal cortex and hippocampus of rats after systemic administration of the convulsants N-methyl-D-aspartate, pentylentetrazol, picrotoxinine, lindane and 4-aminopyridine.
Topics: Aminopyrine; Analysis of Variance; Animals; Convulsants; Drug Evaluation, Preclinical; Evaluation Studies as Topic; Excitatory Amino Acid Agonists; Frontal Lobe; Hexachlorocyclohexane; Hippocampus; Kainic Acid; Male; N-Methylaspartate; Pentylenetetrazole; Picrotoxin; Putrescine; Rats; Rats, Wistar; Sesterterpenes | 1996 |
A behavioural and neurochemical study in rats of the pharmacology of loreclezole, a novel allosteric modulator of the GABAA receptor.
Topics: Allosteric Regulation; Animals; Behavior, Animal; Brain Chemistry; Bridged Bicyclo Compounds, Heterocyclic; Cerebral Cortex; Chlormethiazole; Dose-Response Relationship, Drug; GABA Modulators; Hypnotics and Sedatives; Male; Muscle Relaxation; Pentobarbital; Picrotoxin; Rats; Receptors, GABA-A; Seizures; Sesterterpenes; Triazoles | 1996 |
Pharmacology of skeletal muscle GABA-gated chloride channels in the cockroach Periplaneta americana.
Topics: Animals; Bicuculline; Bridged Bicyclo Compounds, Heterocyclic; Chloride Channels; Flunitrazepam; GABA Agonists; GABA Antagonists; gamma-Aminobutyric Acid; Ion Channel Gating; Isonicotinic Acids; Male; Motor Neurons; Muscle, Skeletal; Periplaneta; Picrotoxin; Receptors, GABA; Sesterterpenes | 1997 |
Cloning and characterization of mouse GABA(C) receptor subunits.
Topics: Amino Acid Sequence; Animals; Blotting, Northern; Cloning, Molecular; DNA; Mice; Molecular Sequence Data; Oocytes; Picrotoxin; Rats; Receptors, GABA; Retina; Sesterterpenes; Transcription, Genetic; Xenopus | 1998 |
Functional properties of glycine receptors expressed in primary cultures of mouse cerebellar granule cells.
Topics: Animals; beta-Alanine; Binding, Competitive; Cell Membrane; Cells, Cultured; Cerebellum; Cerebral Cortex; Female; Glycine; Isonicotinic Acids; Kinetics; Mice; Mice, Inbred Strains; Neurons; Oocytes; Patch-Clamp Techniques; Picrotoxin; Radioligand Assay; Receptors, Glycine; RNA, Messenger; Sesterterpenes; Strychnine; Taurine; Time Factors; Tritium; Xenopus laevis | 1998 |
Multiple picrotoxinin effect on glycine channels in rat hippocampal neurons.
Topics: Action Potentials; Animals; Chloride Channels; Chlorides; GABA Antagonists; Hippocampus; Ion Transport; Ionophores; Nerve Tissue Proteins; Neurons; Patch-Clamp Techniques; Picrotoxin; Rats; Rats, Sprague-Dawley; Receptors, Glycine; Sesterterpenes | 1998 |
Simultaneous glutamate and perfusion fMRI responses to regional brain stimulation.
Topics: Animals; Brain; Cerebrovascular Circulation; GABA-A Receptor Antagonists; Glutamic Acid; Image Processing, Computer-Assisted; Magnetic Resonance Imaging; Male; Microdialysis; Osmolar Concentration; Picrotoxin; Rats; Rats, Sprague-Dawley; Sesterterpenes | 1998 |
Inhibition of GABA-gated chloride channels by 12,14-dichlorodehydroabietic acid in mammalian brain.
Topics: Abietanes; Amphotericin B; Animals; Binding Sites; Brain; Bridged Bicyclo Compounds, Heterocyclic; Chloride Channels; Chlorides; Diterpenes; Drug Interactions; gamma-Aminobutyric Acid; Male; Mice; Phenanthrenes; Picrotoxin; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Sesterterpenes; Tetrodotoxin | 1999 |
Actions of 3-[2-phosphonomethyl[1,1-biphenyl]-3-yl]alanine (PMBA) on cloned glycine receptors.
Topics: Animals; Dose-Response Relationship, Drug; Glycine; Glycine Agents; Oocytes; Organophosphonates; Phenylalanine; Picrotoxin; Receptors, Glycine; Recombinant Proteins; Sesterterpenes; Strychnine; Xenopus laevis | 1999 |
The interaction of chlorinated alicyclic insecticides with brain GABA(A) receptors in channel catfish (Ictalurus punctatus).
Topics: Animals; Binding Sites; Brain; Bridged Bicyclo Compounds, Heterocyclic; Edetic Acid; GABA-A Receptor Antagonists; Hydrocarbons, Chlorinated; Ictaluridae; Insecticides; Kinetics; Picrotoxin; Receptors, GABA-A; Sesterterpenes; Sulfur Radioisotopes | 1999 |
Anisatin modulation of the gamma-aminobutyric acid receptor-channel in rat dorsal root ganglion neurons.
Topics: Affinity Labels; Animals; Animals, Newborn; Bridged Bicyclo Compounds, Heterocyclic; Cells, Cultured; Electric Stimulation; Electrophysiology; GABA Antagonists; gamma-Aminobutyric Acid; Ganglia, Spinal; Insecticides; Kinetics; Lactones; Membrane Potentials; Neurons; Patch-Clamp Techniques; Picrotoxin; Plants; Rats; Receptors, GABA; Sesquiterpenes; Sesterterpenes; Spiro Compounds | 1999 |
Synaptic membrane freezing affects modulatory sites in avian central nervous system GABA(A) receptor.
Topics: Animals; Binding Sites; Chickens; Drug Synergism; Freezing; GABA Modulators; gamma-Aminobutyric Acid; Hypnotics and Sedatives; Pentobarbital; Picrotoxin; Pregnanolone; Receptors, GABA-A; Sesterterpenes; Synaptic Membranes; Tectum Mesencephali; Tritium | 1999 |
Chloride channels of glycine and GABA receptors with blockers: Monte Carlo minimization and structure-activity relationships.
Topics: Amino Acid Sequence; Animals; Binding Sites; Biophysical Phenomena; Biophysics; Borates; Chloride Channels; Humans; Macromolecular Substances; Models, Molecular; Molecular Sequence Data; Monte Carlo Method; Picrotoxin; Rats; Receptors, GABA; Receptors, Glycine; Sesterterpenes; Structure-Activity Relationship; Thermodynamics | 2000 |
Generation of 2-arachidonoylglycerol, an endogenous cannabinoid receptor ligand, in picrotoxinin-administered rat brain.
Topics: Animals; Arachidonic Acids; Brain; Central Nervous System Stimulants; Chromatography, High Pressure Liquid; Dronabinol; Endocannabinoids; Feedback; Glycerides; Ligands; Male; Picrotoxin; Rats; Rats, Wistar; Receptors, Cannabinoid; Receptors, Drug; Sesterterpenes; Synaptic Transmission | 2000 |
Subunit-specific action of an anticonvulsant thiobutyrolactone on recombinant glycine receptors involves a residue in the M2 membrane-spanning region.
Topics: 4-Butyrolactone; Amino Acid Sequence; Amino Acids; Animals; Anticonvulsants; Humans; Membrane Proteins; Molecular Sequence Data; Mutation; Oocytes; Picrotoxin; Rats; Receptors, Glycine; Recombinant Proteins; Sequence Homology, Amino Acid; Sesterterpenes; Transfection; Xenopus | 2000 |
Pharmacology of GABA(A) receptors of retinal dopaminergic neurons.
Topics: Alkaline Phosphatase; Animals; Benzodiazepines; Bicuculline; Binding Sites; Dopamine; Dose-Response Relationship, Drug; GABA Antagonists; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Humans; Mice; Mice, Transgenic; Neurons; Osmolar Concentration; Patch-Clamp Techniques; Picrotoxin; Pregnanediones; Protein Isoforms; Receptors, GABA-A; Retina; Sesterterpenes; Triazoles; Zinc | 2000 |
Characterization of gamma-aminobutyrate type A receptors with atypical coupling between agonist and convulsant binding sites in discrete brain regions.
Topics: Affinity Labels; Animals; Azides; Benzodiazepines; Binding, Competitive; Bridged Bicyclo Compounds, Heterocyclic; Cerebellum; Chickens; Convulsants; GABA Agonists; gamma-Aminobutyric Acid; Humans; Male; Muscimol; Picrotoxin; Radioligand Assay; Rats; Rats, Wistar; Receptors, GABA-A; Sesterterpenes; Sulfur Radioisotopes; Thalamus; Tritium | 2001 |
Fipronil modulation of gamma-aminobutyric acid(A) receptors in rat dorsal root ganglion neurons.
Topics: Animals; Antiparasitic Agents; Binding, Competitive; Cells, Cultured; Dose-Response Relationship, Drug; Drug Interactions; Ganglia, Spinal; In Vitro Techniques; Kinetics; Membrane Potentials; Neurons; Picrotoxin; Pyrazoles; Rats; Receptors, GABA-A; Sesterterpenes | 2001 |
GLC-3: a novel fipronil and BIDN-sensitive, but picrotoxinin-insensitive, L-glutamate-gated chloride channel subunit from Caenorhabditis elegans.
Topics: Amino Acid Sequence; Animals; Antinematodal Agents; Antiparasitic Agents; Bridged Bicyclo Compounds; Caenorhabditis elegans; Chloride Channels; Convulsants; DNA, Complementary; Insecticides; Ivermectin; Molecular Sequence Data; Nitriles; Oocytes; Picrotoxin; Polymerase Chain Reaction; Pyrazoles; Sequence Homology, Amino Acid; Sesterterpenes; Transfection; Xenopus laevis | 2001 |
Synaptic currents generating the inhibitory surround of ganglion cells in the mammalian retina.
Topics: Action Potentials; Animals; Chlorides; Dendrites; GABA Antagonists; GABA-A Receptor Antagonists; In Vitro Techniques; Light; Membrane Potentials; Neural Inhibition; Patch-Clamp Techniques; Photic Stimulation; Picrotoxin; Potassium; Rabbits; Receptors, GABA; Receptors, GABA-A; Receptors, Glycine; Retina; Retinal Ganglion Cells; Sesterterpenes; Sodium; Synapses; Synaptic Transmission; Tetrodotoxin | 2001 |
Activation of GABA(A) receptors in subthalamic neurons in vitro: properties of native receptors and inhibition mechanisms.
Topics: Animals; Bicarbonates; Bicuculline; Chlorides; Diazepam; Electrophysiology; Flunitrazepam; GABA Agonists; GABA Antagonists; GABA Modulators; Membrane Potentials; Muscimol; Neural Inhibition; Neurons; Organ Culture Techniques; Pentobarbital; Picrotoxin; Rats; Rats, Wistar; Receptors, GABA-A; Sesterterpenes; Subthalamic Nucleus | 2001 |
Control of serotonergic function in medial prefrontal cortex by serotonin-2A receptors through a glutamate-dependent mechanism.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amphetamines; Animals; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Female; Fluorobenzenes; GABA Antagonists; Glutamic Acid; Hallucinogens; Male; Mice; Mice, Inbred BALB C; Microdialysis; Neurons; Picrotoxin; Piperidines; Prefrontal Cortex; Raphe Nuclei; Rats; Rats, Wistar; Receptor, Serotonin, 5-HT2A; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists; Sesterterpenes; Tetrodotoxin | 2001 |
Bilobalide, a sesquiterpene trilactone from Ginkgo biloba, is an antagonist at recombinant alpha1beta2gamma2L GABA(A) receptors.
Topics: Animals; Bicuculline; Cyclopentanes; Diterpenes; Dose-Response Relationship, Drug; Furans; GABA Antagonists; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Ginkgo biloba; Ginkgolides; Humans; Membrane Potentials; Oocytes; Picrotoxin; Receptors, GABA-A; Recombinant Proteins; Sesterterpenes; Xenopus laevis | 2003 |
RdlDv, a novel GABA-gated chloride channel gene from the American dog tick Dermacentor variabilis.
Topics: Amino Acid Sequence; Animals; Chloride Channels; Cloning, Molecular; Dermacentor; Dieldrin; Dogs; Drosophila Proteins; gamma-Aminobutyric Acid; Insect Proteins; Insecticide Resistance; Ion Channel Gating; Molecular Sequence Data; Oocytes; Patch-Clamp Techniques; Picrotoxin; Pyrazoles; Receptors, GABA-A; Recombinant Proteins; Sequence Homology, Amino Acid; Sesterterpenes; Xenopus | 2003 |
Activation-dependent properties of pregnenolone sulfate inhibition of GABAA receptor-mediated current.
Topics: Animals; Electrophysiology; Female; GABA-A Receptor Antagonists; Hippocampus; Kinetics; Membrane Potentials; Neurons; Oocytes; Patch-Clamp Techniques; Picrotoxin; Pregnenolone; Recombinant Proteins; Sesterterpenes; Sulfates; Xenopus | 2003 |
[Studies on the structure of picrotoxin. I. Formation of picrotoxin from picrotoxinin and picrotin, with remarks on identification of picrotoxin].
Topics: Picrotoxin; Sesterterpenes | 1954 |
Terpene trilactones from Ginkgo biloba are antagonists of cortical glycine and GABA(A) receptors.
Topics: Animals; Cerebral Cortex; Female; GABA-A Receptor Antagonists; Ginkgo biloba; Lactones; Picrotoxin; Pregnancy; Rats; Rats, Sprague-Dawley; Receptors, Glycine; Sesterterpenes; Terpenes | 2003 |
Relationship between picrotin and picrotoxinin.
Topics: Humans; Picrotoxin; Sesterterpenes | 1951 |
The human taste receptor hTAS2R14 responds to a variety of different bitter compounds.
Topics: Bicyclic Monoterpenes; Humans; Immunohistochemistry; In Situ Hybridization; Monoterpenes; Picrotoxin; Receptors, G-Protein-Coupled; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sesterterpenes; Taste Buds | 2004 |
Ginkgolides, diterpene trilactones of Ginkgo biloba, as antagonists at recombinant alpha1beta2gamma2L GABAA receptors.
Topics: Animals; Diterpenes; Dose-Response Relationship, Drug; Electrophysiology; GABA Antagonists; Ginkgo biloba; Ginkgolides; Humans; Lactones; Membrane Potentials; Oocytes; Patch-Clamp Techniques; Picrotoxin; Receptors, GABA-A; Recombinant Proteins; Sesterterpenes; Xenopus laevis | 2004 |
Deriving the glutamate clearance time course from transporter currents in CA1 hippocampal astrocytes: transmitter uptake gets faster during development.
Topics: Age Factors; Amino Acid Transport System X-AG; Animals; Animals, Newborn; Aspartic Acid; Astrocytes; Dose-Response Relationship, Drug; Dose-Response Relationship, Radiation; Electric Stimulation; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Glutamates; Glutamic Acid; Hippocampus; In Vitro Techniques; Male; Membrane Potentials; Patch-Clamp Techniques; Picrotoxin; Rats; Rats, Sprague-Dawley; Sesterterpenes; Synapses; Time Factors | 2005 |
Functional characterization of Musca glutamate- and GABA-gated chloride channels expressed independently and coexpressed in Xenopus oocytes.
Topics: Animals; Antiparasitic Agents; Chloride Channel Agonists; Chloride Channels; Cloning, Molecular; DNA, Complementary; Dose-Response Relationship, Drug; GABA Agonists; GABA Antagonists; gamma-Aminobutyric Acid; Gene Expression; Glutamates; Hexachlorocyclohexane; Ion Channel Gating; Muscidae; Oocytes; Picrotoxin; Protein Structure, Quaternary; Pyrazoles; RNA, Complementary; Sesterterpenes; Xenopus laevis | 2006 |
Rat alpha6beta2delta GABAA receptors exhibit two distinct and separable agonist affinities.
Topics: Action Potentials; Animals; beta-Alanine; Bicuculline; Crotonates; Desoxycorticosterone; Dose-Response Relationship, Drug; Female; Furosemide; GABA Agonists; GABA Antagonists; GABA-A Receptor Agonists; gamma-Aminobutyric Acid; Imidazoles; Microinjections; Mutation; Neural Inhibition; Neurons; Oocytes; Picrotoxin; Pyridazines; Rats; Receptors, GABA-A; Sesterterpenes; Taurine; Xenopus laevis; Zinc | 2007 |
Mechanisms for picrotoxinin and picrotin blocks of alpha2 homomeric glycine receptors.
Topics: Animals; CHO Cells; Cricetinae; Cricetulus; Dose-Response Relationship, Drug; Evoked Potentials; GABA Antagonists; Glycine; Humans; Membrane Potentials; Patch-Clamp Techniques; Picrotoxin; Protein Binding; Protein Conformation; Receptors, Glycine; Sesterterpenes; Transfection | 2007 |
Investigation of structural requirements for inhibitory activity at the rat and housefly picrotoxinin binding sites in ionotropic GABA receptors using DISCOtech and CoMFA.
Topics: Animals; Binding Sites; GABA Antagonists; Houseflies; Models, Molecular; Molecular Structure; Picrotoxin; Quantitative Structure-Activity Relationship; Rats; Receptors, GABA; Sesterterpenes | 2007 |
A proposed structural basis for picrotoxinin and picrotin binding in the glycine receptor pore.
Topics: Data Interpretation, Statistical; DNA, Complementary; Electrophysiology; Glycine; Humans; Hydrogen Bonding; Models, Molecular; Mutagenesis; Neurons, Afferent; Pain; Patch-Clamp Techniques; Picrotoxin; Receptors, GABA-A; Receptors, Glycine; Sesterterpenes; Synapses | 2007 |
Relative impact of residues at the intracellular and extracellular ends of the human GABAC rho1 receptor M2 domain on picrotoxinin activity.
Topics: Allosteric Regulation; Animals; Binding Sites; Binding, Competitive; GABA Antagonists; Humans; Mutation; Oocytes; Phosphinic Acids; Picrotoxin; Protein Subunits; Pyridines; Receptors, GABA; Receptors, GABA-B; Sesterterpenes; Xenopus laevis | 2008 |
Role of a serine residue (S278) in the pore-facing region of the housefly L-glutamate-gated chloride channel in determining sensitivity to noncompetitive antagonists.
Topics: Amino Acid Sequence; Amino Acid Substitution; Animals; Chloride Channels; Dose-Response Relationship, Drug; Glutamic Acid; Hexachlorocyclohexane; Houseflies; Insecticides; Ion Channel Gating; Membrane Potentials; Molecular Structure; Picrotoxin; Pyrazoles; Serine; Sesterterpenes; Sodium Chloride | 2008 |
Dihydropyridine inhibition of the glycine receptor: subunit selectivity and a molecular determinant of inhibition.
Topics: Amino Acid Sequence; Analysis of Variance; Binding Sites; Biophysical Phenomena; Calcium Channel Blockers; Cell Line, Transformed; Dihydropyridines; Dose-Response Relationship, Drug; Electric Stimulation; GABA Antagonists; Humans; Membrane Potentials; Models, Molecular; Molecular Sequence Data; Mutagenesis, Site-Directed; Patch-Clamp Techniques; Picrotoxin; Protein Subunits; Receptors, Glycine; Sesterterpenes; Structure-Activity Relationship | 2009 |
Site-specific fluorescence reveals distinct structural changes induced in the human rho 1 GABA receptor by inhibitory neurosteroids.
Topics: Dose-Response Relationship, Drug; Estradiol; Fluorescence; GABA-B Receptor Antagonists; gamma-Aminobutyric Acid; Humans; Mutation; Neurotransmitter Agents; Picrotoxin; Protein Conformation; Receptors, GABA-B; Sesterterpenes | 2010 |
Inner and outer retinal mechanisms engaged by epiretinal stimulation in normal and rd mice.
Topics: Animals; Biophysics; Calcium; Disease Models, Animal; Electric Stimulation; Evoked Potentials; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; GABA-A Receptor Antagonists; Glycine Agents; In Vitro Techniques; Mice; Mice, Inbred C57BL; Mice, Mutant Strains; Microscopy, Confocal; Patch-Clamp Techniques; Picrotoxin; Quinoxalines; Retina; Retinal Degeneration; Retinal Ganglion Cells; Sesterterpenes; Strychnine; Visual Pathways | 2011 |
Binding sites for bilobalide, diltiazem, ginkgolide, and picrotoxinin at the 5-HT3 receptor.
Topics: Amino Acid Sequence; Animals; Binding Sites; Cyclopentanes; Diltiazem; Female; Furans; Ginkgolides; Humans; Molecular Sequence Data; Picrotoxin; Radioligand Assay; Receptors, Serotonin, 5-HT3; Sequence Homology, Amino Acid; Sesterterpenes; Xenopus laevis | 2011 |
Cys-loop receptor channel blockers also block GLIC.
Topics: Bacterial Proteins; Cysteine Loop Ligand-Gated Ion Channel Receptors; Hexachlorocyclohexane; Humans; Ion Channel Gating; Picrotoxin; Protein Binding; Rimantadine; Sesterterpenes | 2011 |
Plant regeneration, genetic fidelity, and active ingredient content of encapsulated hairy roots of Picrorhiza kurrooa Royle ex Benth.
Topics: Agrobacterium; Blotting, Southern; Cell Line; Culture Media; DNA Fingerprinting; Genotype; Picrorhiza; Picrotoxin; Plant Roots; Plant Shoots; Polymerase Chain Reaction; Random Amplified Polymorphic DNA Technique; Regeneration; Sesterterpenes; Temperature; Transformation, Genetic | 2013 |
Long-lasting intrinsic persistent firing in rat CA1 pyramidal cells: a possible mechanism for active maintenance of memory.
Topics: Action Potentials; Animals; Animals, Newborn; CA1 Region, Hippocampal; Carbachol; Cholinergic Agonists; Electric Stimulation; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Female; GABA-A Receptor Antagonists; Glutamic Acid; In Vitro Techniques; Kynurenic Acid; Male; Picrotoxin; Pyramidal Cells; Rats; Rats, Long-Evans; Sesterterpenes; Time Factors | 2013 |
Amyloid precursor proteins interact with the heterotrimeric G protein Go in the control of neuronal migration.
Topics: Amyloid beta-Protein Precursor; Animals; Binding Sites; Brain; Cell Movement; Chlorocebus aethiops; COS Cells; Embryo, Nonmammalian; Enteric Nervous System; Female; GABA-A Receptor Antagonists; GTP-Binding Protein alpha Subunits, Gi-Go; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Immunoprecipitation; Luminescent Proteins; Male; Manduca; Mice; Morpholinos; Mutation; Neurons; Picrotoxin; Protein Binding; Sesterterpenes; Transfection | 2013 |
The response of juxtacellular labeled GABA interneurons in the basolateral amygdaloid nucleus anterior part to 5-HT₂A/₂C receptor activation is decreased in rats with 6-hydroxydopamine lesions.
Topics: Action Potentials; Aminopyridines; Amphetamines; Amygdala; Animals; GABA-A Receptor Antagonists; GABAergic Neurons; Glutamate Decarboxylase; Indoles; Interneurons; Male; Microinjections; Oxidopamine; Picrotoxin; Rats; Receptor, Serotonin, 5-HT2A; Receptor, Serotonin, 5-HT2C; Serotonin 5-HT2 Receptor Agonists; Serotonin 5-HT2 Receptor Antagonists; Sesterterpenes; Substantia Nigra | 2013 |
Over-expression of Mash1 improves the GABAergic differentiation of bone marrow mesenchymal stem cells in vitro.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Basic Helix-Loop-Helix Transcription Factors; Cell Count; Cell Differentiation; Cells, Cultured; Excitatory Amino Acid Antagonists; GABA-A Receptor Antagonists; GABAergic Neurons; Glutamate Decarboxylase; Male; Membrane Potentials; Mesenchymal Stem Cells; Neurons; Phosphopyruvate Hydratase; Picrotoxin; Rats; Rats, Sprague-Dawley; Sesterterpenes; Valine | 2013 |
The novel isoxazoline ectoparasiticide fluralaner: selective inhibition of arthropod γ-aminobutyric acid- and L-glutamate-gated chloride channels and insecticidal/acaricidal activity.
Topics: Amino Acid Sequence; Animals; Chloride Channels; Cloning, Molecular; Ctenocephalides; Dieldrin; DNA, Complementary; Drosophila melanogaster; GABA Antagonists; gamma-Aminobutyric Acid; HEK293 Cells; Humans; Insect Proteins; Insecticides; Isoxazoles; Molecular Sequence Data; Phylogeny; Picrotoxin; Pyrazoles; Rhipicephalus; Sequence Alignment; Sesterterpenes; Xenopus laevis | 2014 |
Global optogenetic activation of inhibitory interneurons during epileptiform activity.
Topics: 4-Aminopyridine; Animals; Channelrhodopsins; Female; GABA-A Receptor Antagonists; Gene Expression Regulation; Hippocampus; In Vitro Techniques; Interneurons; Luminescent Proteins; Male; Membrane Potentials; Mice; Mice, Inbred C57BL; Mice, Transgenic; Neural Inhibition; Optogenetics; Parvalbumins; Picrotoxin; Potassium Channel Blockers; Red Fluorescent Protein; Sesterterpenes; Time Factors | 2014 |
Phenylalanine in the pore of the Erwinia ligand-gated ion channel modulates picrotoxinin potency but not receptor function.
Topics: Amino Acid Sequence; Animals; Bacterial Proteins; Binding Sites; Binding, Competitive; Cysteine Loop Ligand-Gated Ion Channel Receptors; Erwinia; Female; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Ion Channel Gating; Membrane Potentials; Models, Molecular; Molecular Sequence Data; Mutation, Missense; Oocytes; Phenylalanine; Picrotoxin; Protein Structure, Secondary; Protein Structure, Tertiary; Sequence Homology, Amino Acid; Sesterterpenes; Xenopus laevis | 2014 |
5-HT3a Receptors Modulate Hippocampal Gamma Oscillations by Regulating Synchrony of Parvalbumin-Positive Interneurons.
Topics: Animals; Apamin; Benzodiazepines; Carbachol; Cholinergic Agonists; Excitatory Postsynaptic Potentials; GABA-A Receptor Antagonists; Gamma Rhythm; Hippocampus; Hormone Antagonists; In Vitro Techniques; Interneurons; Mice; Mice, Transgenic; Parvalbumins; Patch-Clamp Techniques; Picrotoxin; Receptors, Serotonin, 5-HT3; Serotonin Agents; Sesterterpenes; Spectrum Analysis | 2016 |
Restoring Light Sensitivity in Blind Retinae Using a Photochromic AMPA Receptor Agonist.
Topics: Action Potentials; Animals; Animals, Newborn; Blindness; Cyclic Nucleotide-Gated Cation Channels; Disease Models, Animal; GABA Agents; GluK2 Kainate Receptor; HEK293 Cells; Hippocampus; Humans; Light; Mice; Mice, Inbred C57BL; Mice, Knockout; Neurons; Phosphinic Acids; Picrotoxin; Pyridines; Receptors, AMPA; Receptors, Kainic Acid; Retinal Ganglion Cells; rho GTP-Binding Proteins; Rod Opsins; Sesterterpenes | 2016 |
Expression pattern and pharmacological characterisation of two novel alternative splice variants of the glutamate-gated chloride channel in the small brown planthopper Laodelphax striatellus.
Topics: Alternative Splicing; Amino Acid Sequence; Animals; Base Sequence; Chloride Channels; Cloning, Molecular; DNA, Complementary; Female; GABA-A Receptor Antagonists; Glutamic Acid; Hemiptera; Insect Proteins; Insecticides; Lethal Dose 50; Male; Nymph; Picrotoxin; Pyrazoles; Sequence Alignment; Sesterterpenes | 2017 |
The binding mode of picrotoxinin in GABA
Topics: Binding Sites; Cell Membrane; Hydrogen Bonding; Hydrophobic and Hydrophilic Interactions; Inhibitory Concentration 50; Ligands; Models, Biological; Molecular Docking Simulation; Molecular Structure; Picrotoxin; Protein Domains; Receptors, GABA-A; Sequence Homology, Nucleic Acid; Sesterterpenes | 2016 |
Side chain flexibility and the pore dimensions in the GABAA receptor.
Topics: Amino Acid Sequence; Biophysics; Computer Simulation; Crystallography, X-Ray; Humans; Ions; Models, Molecular; Monte Carlo Method; Picrotoxin; Protein Conformation; Receptors, GABA-A; Receptors, Glycine; Sesterterpenes; Structural Homology, Protein | 2016 |
Effects of bilobalide, ginkgolide B and picrotoxinin on GABA
Topics: Animals; Cyclopentanes; Dose-Response Relationship, Drug; Electrophysiological Phenomena; Furans; GABA Modulators; Ginkgo biloba; Ginkgolides; Humans; Lactones; Picrotoxin; Receptors, GABA-A; Sesterterpenes; Terpenes; Xenopus laevis | 2017 |
α2-glycine receptors modulate adult hippocampal neurogenesis and spatial memory.
Topics: Animals; Cell Proliferation; Cells, Cultured; Exploratory Behavior; Female; GABA-A Receptor Antagonists; Glycine Agents; Hippocampus; Male; Maze Learning; Memory Disorders; Mice; Mice, Inbred C57BL; Mice, Transgenic; Nestin; Neurogenesis; Neurons; Picrotoxin; Rats; Rats, Inbred F344; Receptors, Glycine; Sesterterpenes; Spatial Memory; Strychnine | 2017 |
Reengineering the ligand sensitivity of the broadly tuned human bitter taste receptor TAS2R14.
Topics: Amino Acid Sequence; Aristolochic Acids; Bicyclic Monoterpenes; Binding Sites; Humans; Ligands; Models, Molecular; Molecular Docking Simulation; Monoterpenes; Mutagenesis, Site-Directed; Mutation; Picrotoxin; Protein Binding; Protein Conformation; Protein Engineering; Receptors, G-Protein-Coupled; Sesterterpenes; Taste | 2018 |
Synthesis of (-)-Picrotoxinin by Late-Stage Strong Bond Activation.
Topics: Molecular Conformation; Picrotoxin; Sesterterpenes; Stereoisomerism | 2020 |
Agonist and antagonist properties of an insect GABA-gated chloride channel (RDL) are influenced by heterologous expression conditions.
Topics: 3' Untranslated Regions; Amino Acid Sequence; Animals; Bees; Chloride Channel Agonists; Chloride Channels; Drosophila melanogaster; Drosophila Proteins; Female; gamma-Aminobutyric Acid; Picrotoxin; Propofol; Receptors, Glycine; Sesterterpenes; Xenopus laevis | 2021 |
Revision of the Unstable Picrotoxinin Hydrolysis Product.
Topics: Carbon-13 Magnetic Resonance Spectroscopy; Carboxylic Acids; Hydrogen-Ion Concentration; Hydrolysis; Picrotoxin; Proton Magnetic Resonance Spectroscopy; Sesterterpenes; Sodium Hydroxide | 2021 |