picrotoxin has been researched along with phenobarbital in 78 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 49 (62.82) | 18.7374 |
| 1990's | 17 (21.79) | 18.2507 |
| 2000's | 8 (10.26) | 29.6817 |
| 2010's | 3 (3.85) | 24.3611 |
| 2020's | 1 (1.28) | 2.80 |
| Authors | Studies |
|---|---|
| Haefely, W; Polc, P | 1 |
| Bennett, EL; Flood, JF; Jarvik, ME; Orme, AE; Rosenzweig, MR | 1 |
| Javid, MJ; Stone, WE | 1 |
| Georgiev, VP; Petkova, BP | 1 |
| Costa, E; Guidotti, A; Mao, CC; Suria, A | 1 |
| Barker, JL; Macdonald, RL | 1 |
| Frey, HH; Löscher, W | 1 |
| Horton, RW; Meldrum, BS; Sawaya, MC; Stephenson, JD | 1 |
| Cole, FR; Nelson, RB | 1 |
| Allan, AM; Draski, LJ; Mayes, GG | 1 |
| Faktorová, M; Kubová, H; Mares, P | 1 |
| McIntyre, T; Skolnick, P | 1 |
| Batatinha, MJ; Bernardi, MM; De Souza-Spinosa, H; Giorgi, R | 1 |
| Kang, T; Xiao-Hong, D; Xin-Quan, J | 1 |
| Georgiev, V; Getova, D; Ivanova, V | 1 |
| Baker, K; Clifford, DB; Covey, DF; Yang, J; Zorumski, CF | 1 |
| Kulkarni, SK; Ticku, MK | 1 |
| Kirkness, EF; Turner, AJ | 1 |
| Mehta, AK; Ticku, MK | 2 |
| Gross, RA; Macdonald, RL; Weddle, MG | 1 |
| Fujiwara, M; Kurahashi, K; Okamoto, T; Tsubomura, T | 1 |
| Bender, AS; Hertz, L | 1 |
| Rastogi, SK; Thyagarajan, R; Ticku, MK | 1 |
| Dewhurst, DG | 1 |
| Gormley, JM; Richter, JA | 1 |
| Chweh, AY; Coleman, JC; Shenoy, AK; Swinyard, EA | 1 |
| Owasoyo, JO; Walker, CA | 1 |
| Baxter, BL | 1 |
| Frank, GB; Jhamandas, K | 1 |
| Izquierdo, I | 1 |
| Kazama, K | 1 |
| Baxter, MG; Miller, AA; Webster, RA | 1 |
| Swinyard, EA | 1 |
| Cuparencu, B; Grosu, L | 1 |
| Marcus, RJ; Roberts, E; Simonsen, DG; Winters, WD | 1 |
| Kuriyama, K | 1 |
| Hata, T; Kita, T; Murakami, T; Okage, T | 1 |
| Ferngren, H | 1 |
| Ljungberg, S; Paalzow, L; Ström, S | 1 |
| Hahn, F; Kretzschmar, R; Meyer, HJ | 1 |
| Bartels, E; Rosenberg, P | 1 |
| Morgan, WW; Pfeil, KA | 1 |
| Kamp, CW; Morgan, WW | 1 |
| Nicoll, RA; Wojtowicz, JM | 1 |
| Leeb-Lundberg, F; Olsen, RW; Snowman, A | 1 |
| Owasoyo, JO | 1 |
| Gormley, JM; Holtman, JR; Richter, JA; Simon, JR | 1 |
| Fukuda, H; Goto, M; Kondo, M | 1 |
| Casida, JE; Gammon, DW; Lawrence, LJ | 1 |
| Obara, N | 1 |
| Elia, AP; Phillips, IR; Shephard, EA | 1 |
| Golovko, AI; Sofronov, GA | 1 |
| Amabeoku, GJ; Chikuni, O | 1 |
| Fujisaki, H; Hamaguchi, T; Ishii, Y; Kaneko, H; Oguri, K; Yamada, H | 1 |
| Godlevsky, LS; Mazarati, AM; Shandra, AA; Vastyanov, RS | 1 |
| Donevan, SD; Rho, JM; Rogawski, MA | 1 |
| Covey, DF; Ferrendelli, JA; Krause, JE; Rothman, SM; Tucker, JB; Weiss, DS; White, G; Williams, KL | 1 |
| Francischi, JN; Pesquero, SM; Salgado, JV; Santana, MA; Tatsuo, MA; Yokoro, CM | 1 |
| Greenfield, LJ; Macdonald, RL; Neelands, TR; Turner, RS; Zhang, J | 1 |
| Matsuki, Y; Oguri, K; Yamada, H | 1 |
| Francischi, JN; Pesquero, SM; Tatsuo, MA; Turchetti-Maia, RM; Yokoro, CM | 1 |
| Paul, V | 1 |
| MEIDINGER, F | 1 |
| DORYWALSKI, T; FALDA, Z | 1 |
| HAHN, F; OBERDORF, A | 1 |
| SIGG, EB; WARNER, CL; YEN, HC | 1 |
| CHUBB, FL; HAJDU, A; KOMLOSSY, J; LEE, CF; MCCOLL, JD | 1 |
| Mackenzie, L; Pope, KJ; Willoughby, JO | 1 |
| de Oliveira, DL; Frizzo, ME; Horn, JF; Moriguchi, E; Rodrigues, JM; Souza, DO; Wofchuk, S | 1 |
| Ekambaram, P; Paul, V | 2 |
| Ekambaram, P; Paul, V; Reddy, L | 1 |
| Errington, AC; Lees, G; Stöhr, T | 1 |
| Nogueira, CW; Prigol, M; Wilhelm, EA; Zeni, G | 1 |
| Adio, O; Fageyinbo, S; Sowemimo, AA | 1 |
| Bai, XY; Du, GH; Hao, LH; Huang, ZL; Liu, R; Sun, ZM; Wu, S; Zhang, WK; Zhang, XQ; Zhang, YH | 1 |
| Gharpure, A; Hibbs, RE; Howard, RJ; Kim, JJ; Lindahl, E; Noviello, CM; Teng, J; Walsh, RM; Zhu, S; Zhuang, Y | 1 |
2 review(s) available for picrotoxin and phenobarbital
| Article | Year |
|---|---|
New concepts on the mechanism of action of benzodiazepines.
Topics: Animals; Benzodiazepines; Cerebellum; Chlordiazepoxide; Cyclic AMP; Diazepam; gamma-Aminobutyric Acid; Ganglia, Autonomic; Glycine; Humans; Isoniazid; Medulla Oblongata; Pentylenetetrazole; Phenobarbital; Phenytoin; Picrotoxin; Receptors, Drug; Seizures; Sensory Receptor Cells; Spinal Cord; Strychnine; Substantia Nigra | 1975 |
Laboratory evaluation of antiepileptic drugs. Review of laboratory methods.
Topics: Animals; Anticonvulsants; Biological Assay; Brain Injuries; Diagnosis; Electroconvulsive Therapy; Electroshock; Humans; Methionine Sulfoximine; Methods; Pentylenetetrazole; Phenobarbital; Phenytoin; Picrotoxin; Seizures; Strychnine; Thiosemicarbazones; Trimethadione; Urea | 1969 |
76 other study(ies) available for picrotoxin and phenobarbital
| Article | Year |
|---|---|
Effects of two benzodiazepines, phenobarbitone, and baclofen on synaptic transmission in the cat cuneate nucleus.
Topics: Aminobutyrates; Aminooxyacetic Acid; Animals; Anti-Anxiety Agents; Baclofen; Bicuculline; Cats; Diazepam; Drug Interactions; Evoked Potentials; Flunitrazepam; Glutamate Decarboxylase; Medulla Oblongata; Neural Inhibition; Phenobarbital; Picrotoxin; Propionates; Semicarbazides; Synapses; Synaptic Transmission | 1976 |
The effect of stimulants, depressants, and protein synthesis- inhibition on retention.
Topics: Amnesia; Animals; Anisomycin; Arousal; Avoidance Learning; Central Nervous System Stimulants; Chloral Hydrate; Conditioning, Operant; Dextroamphetamine; Drug Antagonism; Drug Synergism; Humans; Hypnotics and Sedatives; Male; Memory; Mice; Nerve Tissue Proteins; Phenobarbital; Picrotoxin; Retention, Psychology; Strychnine; Time Factors | 1977 |
Benzodiazepines and phenobarbital as antagonists of dissimilar chemical convulsants.
Topics: 3-Mercaptopropionic Acid; Animals; Anti-Anxiety Agents; Anticonvulsants; Bicuculline; Chlordiazepoxide; Convulsants; Diazepam; gamma-Aminobutyric Acid; Isoniazid; Male; Mice; Nitrazepam; Pentylenetetrazole; Phenobarbital; Picrotoxin; Therapeutic Equivalency | 1978 |
Effect of p-chlorophenylalanine on the central nervous excitability threshold and on the activity of some central depressants.
Topics: Animals; Central Nervous System; Depression, Chemical; Fenclonine; Hypnotics and Sedatives; Injections, Intraperitoneal; Injections, Intravenous; Male; Mice; Pentylenetetrazole; Phenobarbital; Phenylacetates; Picrotoxin; Seizures; Strychnine; Time Factors; Toluene; Urea | 1975 |
Different actions of anticonvulsant and anesthetic barbiturates revealed by use of cultured mammalian neurons.
Topics: Action Potentials; Cells, Cultured; Electric Conductivity; gamma-Aminobutyric Acid; Glutamates; Membrane Potentials; Neurons; Pentobarbital; Phenobarbital; Picrotoxin; Receptors, Neurotransmitter | 1978 |
Di-n-propylacetic acid--profile of anticonvulsant activity in mice.
Topics: Animals; Anticonvulsants; Bicuculline; Dose-Response Relationship, Drug; Electroshock; Ethosuximide; Female; Male; Mice; Pentylenetetrazole; Phenobarbital; Picrotoxin; Seizures; Strychnine; Trimethadione; Valerates; Valproic Acid | 1976 |
Picrotoxin convulsions and GABA metabolism after injection of anticonvulsants in chicks.
Topics: 4-Aminobutyrate Transaminase; Aminobutyrates; Animals; Anticonvulsants; Brain Chemistry; Chickens; Diazepam; gamma-Aminobutyric Acid; Phenobarbital; Picrotoxin | 1976 |
The convulsive profile of Cicuta douglasii (water hemlock).
Topics: Animals; Anticonvulsants; Convulsants; Electroshock; Male; Mice; Pentylenetetrazole; Phenobarbital; Phenytoin; Picrotoxin; Plant Extracts | 1976 |
gamma-Aminobutyric acid-activated chloride channels in rats selectively bred for differential acute sensitivity to alcohol.
Topics: Alcohol Drinking; Animals; Chloride Channels; Diazepam; Female; Flunitrazepam; gamma-Aminobutyric Acid; Membrane Proteins; Muscimol; Pentobarbital; Phenobarbital; Phenotype; Picrotoxin; Rats; Rats, Inbred Strains; Receptors, GABA-A; Selection, Genetic | 1991 |
Effect of phenobarbital on motor seizures elicited by picrotoxin and bicuculline in rats.
Topics: Animals; Bicuculline; Male; Pentylenetetrazole; Phenobarbital; Picrotoxin; Rats; Rats, Inbred Strains; Seizures | 1991 |
t-[35S]butylbicyclophosphorothionate binding under equilibrium and nonequilibrium conditions: differential effects of barbiturates and gamma-aminobutyric acid in the long-sleep and short-sleep selected mouse lines.
Topics: Animals; Barbiturates; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Cell Membrane; Cerebellum; Cerebral Cortex; Chloride Channels; Ethanol; gamma-Aminobutyric Acid; Kinetics; Male; Membrane Proteins; Mice; Pentobarbital; Phenobarbital; Picrotoxin; Receptors, GABA-A; Sesterterpenes; Sleep | 1991 |
Croton zehntneri: possible central nervous system effects in rodents.
Topics: Animals; Anticonvulsants; Brazil; Male; Medicine, Traditional; Mice; Phenobarbital; Picrotoxin; Plant Extracts; Rats; Rats, Inbred Strains; Seizures; Strychnine | 1991 |
Pentobarbital selectively blocks supraspinal morphine analgesia. Evidence for GABAA receptor involvement.
Topics: Analgesia; Animals; Diazepam; Drug Synergism; Injections, Intraventricular; Injections, Spinal; Male; Morphine; Muscimol; Pentobarbital; Phenobarbital; Picrotoxin; Rats; Rats, Inbred Strains; Receptors, GABA-A; Spinal Cord | 1990 |
Investigation of 2-hydroxylamino-5-ethyl-5-sec-pentylbarbituric acid for anxyolitic action.
Topics: Animals; Anti-Anxiety Agents; Conflict, Psychological; Male; Pentobarbital; Phenobarbital; Picrotoxin; Prohibitins; Rats | 1990 |
Alpha-substituted thiobutyrolactones potentiate GABA currents in voltage-clamped chick spinal cord neurons.
Topics: 4-Butyrolactone; Animals; Anticonvulsants; Cells, Cultured; Chick Embryo; Diazepam; Furans; gamma-Aminobutyric Acid; Ion Channels; Membrane Potentials; Phenobarbital; Picrotoxin; Spinal Cord | 1988 |
Interaction between GABAergic anticonvulsants and the NMDA receptor antagonist MK 801 against MES- and picrotoxin-induced convulsions in rats.
Topics: Animals; Anticonvulsants; Diazepam; Dibenzocycloheptenes; Dizocilpine Maleate; Electroshock; Ethanol; Male; Motor Activity; Pentobarbital; Phenobarbital; Phenytoin; Picrotoxin; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Seizures; Stereotyped Behavior | 1989 |
The stimulatory effects of secobarbital and pregnanolone on the GABAA receptor can be blocked selectively.
Topics: Animals; Anthelmintics; Cerebral Cortex; In Vitro Techniques; Ivermectin; Muscimol; Phenobarbital; Picrotoxin; Pregnanes; Pregnanolone; Radioligand Assay; Receptors, GABA-A; Secobarbital; Sesterterpenes; Swine; Synaptic Membranes | 1988 |
Interactions of pentobarbital and phenobarbital with GABAergic drugs against chemoconvulsants in rats.
Topics: Animals; Anticonvulsants; Baclofen; Bicuculline; Convulsants; Diazepam; Drug Interactions; Isoxazoles; Male; Pentobarbital; Phenobarbital; Picrotoxin; Rats; Rats, Inbred Strains; Receptors, GABA-A; Seizures; Strychnine | 1988 |
Benzodiazepine, beta-carboline, and barbiturate actions on GABA responses.
Topics: Animals; Anti-Anxiety Agents; Barbiturates; Bicuculline; Carbolines; Cells, Cultured; Clonazepam; Diazepam; gamma-Aminobutyric Acid; Membrane Potentials; Mice; Neurons; Nitrazepam; Pentobarbital; Phenobarbital; Picrotoxin; Receptors, GABA-A; Spinal Cord | 1986 |
Effects of barbiturates on the inhibitory action of GABA on excitatory response of the stomach to stimulation of vagal afferent fibers in cat.
Topics: Afferent Pathways; Animals; Bicuculline; Cats; Chloralose; Electric Stimulation; Female; gamma-Aminobutyric Acid; Hexamethonium; Hexamethonium Compounds; Kinetics; Male; Phenobarbital; Picrotoxin; Stomach; Vagus Nerve | 1987 |
Evidence for involvement of the astrocytic benzodiazepine receptor in the mechanism of action of convulsant and anticonvulsant drugs.
Topics: Animals; Anticonvulsants; Astrocytes; Barbiturates; Benzodiazepinones; Brain; Carbamazepine; Cells, Cultured; Convulsants; Diazepam; Ethosuximide; Mice; Neurons; Pentylenetetrazole; Phenobarbital; Picrotoxin; Receptors, GABA-A; Sesterterpenes; Trimethadione; Valproic Acid | 1988 |
Separate site(s) of action of optical isomers of 1-methyl-5-phenyl-5-propylbarbituric acid with opposite pharmacological activities at the GABA receptor complex.
Topics: Animals; Anticonvulsants; Brain; Convulsants; In Vitro Techniques; Kinetics; Male; Pentobarbital; Phenobarbital; Picrotoxin; Postural Balance; Rats; Rats, Inbred Strains; Receptors, GABA-A; Stereoisomerism; Time Factors | 1985 |
Non involvement of gamma-aminobutyric acid in catechol-induced seizures.
Topics: Animals; Carbachol; Diazepam; Female; gamma-Aminobutyric Acid; Mice; Muscles; Phenobarbital; Picrotoxin; Receptors, GABA-A; Seizures; Valproic Acid | 1986 |
Inhibition of high-affinity choline uptake in the rat hippocampus by in vivo injection of phenobarbital in the medial septum.
Topics: Acetylcholine; Animals; Choline; Hippocampus; Male; Parasympathetic Nervous System; Phenobarbital; Picrotoxin; Rats; Rats, Inbred Strains; Receptors, GABA-A; Septum Pellucidum | 1986 |
Comparison of anticonvulsant effect of pentobarbital and phenobarbital against seizures induced by maximal electroshock and picrotoxin in rats.
Topics: Amino Acids; Amino Acids, Neutral; Animals; Anticonvulsants; Bicuculline; Electroshock; Male; Muscimol; Pentobarbital; Phenobarbital; Picrotoxin; Rats; Rats, Inbred Strains; Receptors, GABA-A; Seizures | 1986 |
An analysis of the in vivo interactions between chemical convulsants and anticonvulsants.
Topics: Animals; Anticonvulsants; Bicuculline; Convulsants; Diazepam; Dose-Response Relationship, Drug; Drug Interactions; Mice; Pentylenetetrazole; Phenobarbital; Picrotoxin; Valproic Acid | 1985 |
The influence of serotonin, GABA and DL-dopa on the circadian rhythm in the toxicity of picrotoxin, pentylenetetrazol and phenobarbital in mice.
Topics: Aminobutyrates; Animals; Circadian Rhythm; Dihydroxyphenylalanine; gamma-Aminobutyric Acid; Lethal Dose 50; Male; Mice; Pentylenetetrazole; Phenobarbital; Picrotoxin; Serotonin; Time Factors | 1974 |
The effect of selected drugs on the "emotional" behavior elicited via hypothalamic stimulation.
Topics: Amphetamine; Animals; Atropine; Behavior, Animal; Cats; Chlorpromazine; Depression, Chemical; Electric Stimulation; Emotions; Hypothalamus; Imipramine; Meprobamate; Pentylenetetrazole; Phenobarbital; Phenytoin; Picrotoxin; Pregnanediones; Reserpine; Scopolamine; Stimulation, Chemical; Strychnine; Tremorine | 1968 |
Effects of drugs acting alone and in combination on the motor activity of intact mice.
Topics: Adjuvants, Anesthesia; Aminobutyrates; Animals; Bemegride; Caffeine; Central Nervous System; Central Nervous System Stimulants; Chlorpromazine; Diazepam; Diphenhydramine; Female; Glutamates; Hydroxybutyrates; Lactones; Meperidine; Meprobamate; Mice; Motor Activity; Nikethamide; Phenobarbital; Picrotoxin; Promethazine; Reflex; Scopolamine; Seizures; Strychnine; Tranquilizing Agents | 1970 |
Effect on pseudoconditioning of drugs with known central nervous activity.
Topics: Amobarbital; Animals; Avoidance Learning; Behavior, Animal; Caffeine; Cannabis; Chlorpromazine; Conditioning, Psychological; Depression, Chemical; Diazepam; Dibenzylchlorethamine; Female; Meprobamate; Pentylenetetrazole; Phenobarbital; Phenytoin; Picrotoxin; Rats; Stimulation, Chemical; Strychnine; Trimethadione | 1974 |
[Effects of various pharmacological agents on neocortical seizure activities in the rabbit].
Topics: Aminobutyrates; Animals; Cerebral Cortex; Cocaine; Electric Stimulation; Electroencephalography; Evoked Potentials; Lidocaine; Pentylenetetrazole; Phenobarbital; Phenytoin; Picrotoxin; Rabbits; Strychnine | 1972 |
Some studies on the convulsant action of folic acid.
Topics: Alkaloids; Animals; Auditory Threshold; Cerebral Ventricles; Dioxoles; Electroshock; Folic Acid; Folic Acid Antagonists; Glutamates; Injections; Injections, Intravenous; Isoquinolines; Mice; Ouabain; Pentylenetetrazole; Phenobarbital; Phenytoin; Picrotoxin; Seizures; Strychnine | 1973 |
[Effect of some drugs with predominantly central nervous action on the assimilation and dissimilation of proteins].
Topics: Amphetamine; Animals; Barbiturates; Liver; Myocardium; Phenobarbital; Picrotoxin; Protein Deficiency; Proteins; Rats; Spleen | 1972 |
Neuropharmacological studies of imidazole-4-acetic acid actions in the mouse and rat.
Topics: Acetates; Animals; Ataxia; Behavior; Caffeine; Catalepsy; Central Nervous System; Drug Interactions; Drug Synergism; Electroencephalography; Humans; Hydroxybutyrates; Imidazoles; Injections, Intraperitoneal; Male; Mice; Mice, Inbred Strains; Motor Activity; Pentylenetetrazole; Phenobarbital; Picrotoxin; Rats; Rats, Inbred Strains; Sleep; Stimulation, Chemical; Strychnine; Time Factors | 1971 |
Association of bromide with the synaptosomal fraction of mouse brain.
Topics: Acetylcholine; Aminobutyrates; Animals; Binding Sites; Brain Chemistry; Bromides; Centrifugation, Density Gradient; Chlorpromazine; Chromatography, Ion Exchange; Dinitrophenols; Glucose; In Vitro Techniques; Iodoacetates; Lactates; Mice; Mitochondria; Norepinephrine; Ouabain; Phenobarbital; Picrotoxin; Pyruvates; Serotonin; Spectrophotometry; Strychnine; Synapses; Synaptic Vesicles; Tritium | 1970 |
[Introduction of mass psychology in animals to pharmacology. 7. Mutural relation in convulsion of El-mice and drugs acting on the central nervous system].
Topics: Aminobutyrates; Animals; Anticonvulsants; Behavior, Animal; Hydantoins; Imidazoles; Mice; Phenobarbital; Picrotoxin; Psychology; Seizures | 1970 |
Further studies on chemically induced siezures and their antagonism by anticonvulsants during postnatal development in the mouse.
Topics: Animals; Animals, Newborn; Anticonvulsants; Brain; Mice; Pentylenetetrazole; Phenobarbital; Picrotoxin; Seizures; Trimethadione | 1968 |
Anticonvulsant activity of ectylurea in mice.
Topics: Animals; Anticonvulsants; Electroshock; Mice; Phenobarbital; Picrotoxin; Strychnine; Urea | 1968 |
[On the inflence of fluid volume on the efficacy of bemegride, Pentetrazole and picrotoxin in phenobarbital poisoning].
Topics: Animals; Bemegride; Mice; Pentylenetetrazole; Pharmaceutical Vehicles; Phenobarbital; Picrotoxin; Seizures; Sodium Chloride; Solutions; Suspensions | 1968 |
Drug effects on the spontaneous electrical activity of the squid giant axon.
Topics: Acetylcholine; Action Potentials; Animals; Anticonvulsants; Atropine; Axons; Barbiturates; Bromides; Chloroform; Chlorpheniramine; Chlorpromazine; Curare; Dopamine; Electrophysiology; Ethanol; Ethers; Evoked Potentials; Hydantoins; Mollusca; Muscles; Nortropanes; Parasympatholytics; Pentylenetetrazole; Phenobarbital; Phenytoin; Picrotoxin; Procaine; Serotonin; Strychnine; Tetracaine; Tremorine; Trihexyphenidyl; Trimethadione | 1967 |
Depression of cerebellar cGMP by barbiturates. Relationship to locomotor activity.
Topics: Animals; Barbital; Barbiturates; Cerebellum; Cyclic AMP; Dose-Response Relationship, Drug; Male; Motor Activity; Pentobarbital; Phenobarbital; Picrotoxin; Rats; Rats, Inbred Strains; Receptors, Cell Surface; Receptors, GABA-A | 1984 |
Some barbiturates enhance the effect of muscimol on dopamine turnover in the rat retina.
Topics: Animals; Barbital; Barbiturates; Convulsants; Dopamine; Drug Synergism; GABA Antagonists; gamma-Aminobutyric Acid; Light; Male; Methyltyrosines; Muscimol; Oxazoles; Pentobarbital; Phenobarbital; Picrotoxin; Rats; Retina; Sesterterpenes | 1980 |
The effects of pentobarbital and related compounds on frog motoneurons.
Topics: Amino Acids; Animals; Anura; Bicuculline; Chloralose; Chlordiazepoxide; Dose-Response Relationship, Drug; gamma-Aminobutyric Acid; Glutamates; Motor Neurons; Muscimol; Pentobarbital; Phenobarbital; Phenytoin; Picrotoxin; Spinal Cord; Strychnine; Synaptic Transmission | 1980 |
Perturbation of benzodiazepine receptor binding by pyrazolopyridines involves picrotoxinin/barbiturate receptor sites.
Topics: Animals; Benzodiazepines; Binding Sites; Brain; Etazolate; gamma-Aminobutyric Acid; Phenobarbital; Picrotoxin; Pyrazoles; Rats; Rats, Inbred Strains; Receptors, Drug; Sesterterpenes | 1981 |
Comparative effects of phenobarbital and picrotoxin on the choline acetyltransferase activity of specific rat brain areas.
Topics: Animals; Brain; Choline O-Acetyltransferase; Male; Phenobarbital; Picrotoxin; Rats; Rats, Inbred Strains | 1982 |
High-affinity choline uptake in the hippocampus: its relationship to the physiological state produced by administration of barbiturates and other treatments.
Topics: Animals; Barbiturates; Bicuculline; Choline; Convulsants; Hippocampus; Kinetics; Male; Mice; Pentobarbital; Phenobarbital; Picrotoxin; Rats; Rats, Inbred Strains; Septum Pellucidum; Synaptosomes | 1982 |
Effects of barbiturates on the decerebrate rigidity in rats.
Topics: Aminooxyacetic Acid; Amobarbital; Animals; Barbiturates; Decerebrate State; Male; Mephobarbital; Muscle Rigidity; Pentobarbital; Phenobarbital; Picrotoxin; Rats; Rats, Inbred Strains; Time Factors | 1982 |
Pyrethroid toxicology: protective effects of diazepam and phenobarbital in the mouse and the cockroach.
Topics: Allethrins; Animals; Cockroaches; Diazepam; Male; Motor Neurons; Nitriles; Permethrin; Phenobarbital; Picrotoxin; Pyrethrins; Sesterterpenes; Temperature | 1982 |
[Involvement of GABAergic and NMDA systems in drug-induced convulsions in mice].
Topics: Animals; Anticonvulsants; Bicuculline; Calcium Channels; Chloride Channels; Male; Mice; Mice, Inbred Strains; Muscimol; Phenobarbital; Picrotoxin; Receptors, GABA; Receptors, N-Methyl-D-Aspartate; Seizures | 1995 |
Regulation of CYP2B gene expression in the intestinal mucosa.
Topics: Animals; Cytochrome P-450 Enzyme System; Gene Expression Regulation, Enzymologic; Intestinal Mucosa; Intestine, Small; Male; Phenobarbital; Picrotoxin; Rats; Rats, Sprague-Dawley; RNA, Messenger | 1994 |
[Effect of preliminary administration of phenobarbital on the toxicity of GABA-lytics in mice].
Topics: 3-Mercaptopropionic Acid; Animals; Antidotes; Barbiturates; Bicuculline; Diazepam; gamma-Aminobutyric Acid; Male; Mice; Phenobarbital; Picrotoxin; Time Factors | 1993 |
Cimetidine-induced seizures in mice. Antagonism by some GABAergic agents.
Topics: Aminobutyrates; Aminooxyacetic Acid; Animals; Baclofen; Bicuculline; Cimetidine; Diazepam; Female; Mice; Muscimol; Phenobarbital; Phenytoin; Picrotoxin; Receptors, GABA; Seizures; Strychnine | 1993 |
Picrotoxin as a potent inducer of rat hepatic cytochrome P450, CYP2B1 and CYP2B2.
Topics: Animals; Cytochrome P-450 Enzyme System; Enzyme Induction; Male; Microsomes, Liver; Oxidoreductases, N-Demethylating; Phenobarbital; Picrotoxin; Rats; Rats, Wistar; Sesterterpenes; Subcellular Fractions; Testosterone; Toxins, Biological | 1993 |
Chemical kindling: implications for antiepileptic drugs - sensitive and resistant epilepsy models.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Epilepsy; Kindling, Neurologic; Male; Phenobarbital; Phenytoin; Picrotoxin; Rats; Rats, Wistar; Seizures | 1996 |
Direct activation of GABAA receptors by barbiturates in cultured rat hippocampal neurons.
Topics: Animals; Cells, Cultured; Chlorides; Dose-Response Relationship, Drug; Electrophysiology; Female; GABA Antagonists; GABA Modulators; GABA-A Receptor Agonists; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Hippocampus; Kinetics; Neurons; Pentobarbital; Phenobarbital; Picrotoxin; Pregnancy; Prohibitins; Rats; Rats, Sprague-Dawley; Time Factors | 1996 |
Lactone modulation of the gamma-aminobutyric acid A receptor: evidence for a positive modulatory site.
Topics: 4-Butyrolactone; Animals; Chlordiazepoxide; Female; Flumazenil; gamma-Aminobutyric Acid; Lactones; Phenobarbital; Picrotoxin; Receptors, GABA-A; Xenopus laevis | 1997 |
Hyperalgesic effect induced by barbiturates, midazolam and ethanol: pharmacological evidence for GABA-A receptor involvement.
Topics: Animals; Barbiturates; Central Nervous System Depressants; Ethanol; GABA Antagonists; GABA Modulators; Hyperalgesia; Male; Midazolam; Pentobarbital; Phenobarbital; Picrotoxin; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Thiopental | 1997 |
GABAA receptor pharmacology and subtype mRNA expression in human neuronal NT2-N cells.
Topics: Anticonvulsants; Bicuculline; Carbolines; Convulsants; Diazepam; Diuretics; DNA Primers; Furosemide; GABA Modulators; GABA-A Receptor Agonists; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Humans; Hypnotics and Sedatives; Lanthanum; Neurons; Patch-Clamp Techniques; Pentobarbital; Phenobarbital; Picrotoxin; Polymerase Chain Reaction; Pregnanediones; Pregnenolone; Pyridines; Receptors, GABA-A; RNA, Messenger; Teratocarcinoma; Triazoles; Tumor Cells, Cultured; Zinc; Zolpidem | 1998 |
Phenobarbital-mediated induction of the CYP2B subfamily is not antagonized by picrotoxin, a potent antagonist of barbiturates in the central nervous system.
Topics: Animals; Central Nervous System; Central Nervous System Depressants; Central Nervous System Stimulants; Cytochrome P-450 CYP2B1; Enzyme Induction; Immunoblotting; Male; Microsomes, Liver; Phenobarbital; Picrotoxin; Rats; Rats, Wistar | 1998 |
Acute phenobarbital administration induces hyperalgesia: pharmacological evidence for the involvement of supraspinal GABA-A receptors.
Topics: Analysis of Variance; Animals; Bicuculline; Dose-Response Relationship, Drug; GABA Antagonists; Hyperalgesia; Hypnotics and Sedatives; Male; Pain Measurement; Pain Threshold; Phenobarbital; Picrotoxin; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Spinal Cord | 2001 |
The effect of N-nitro-L-arginine methyl ester posttreatment on the anticonvulsant effect of phenobarbitone and diazepam on picrotoxin-induced convulsions in rats.
Topics: Animals; Anticonvulsants; Diazepam; Drug Synergism; Male; NG-Nitroarginine Methyl Ester; Phenobarbital; Picrotoxin; Rats; Rats, Wistar; Seizures | 2003 |
[Comparative action of products, numbers 3277 R.P., 4560 R.P., 4909 R.P. and of phenobarbital on convulsions induced by strychnine, picrotoxin, cocaine, cafeine and amphetamine].
Topics: Amphetamine; Amphetamines; Chlorpromazine; Cocaine; Histamine H1 Antagonists; Phenobarbital; Phenothiazines; Picrotoxin; Seizures; Strychnine | 1956 |
[Severe luminal and cyclohexal poisoning treated with picrotoxin and levophed (bitartrate-l-noradrenalin)].
Topics: Barbiturates; Humans; Norepinephrine; Phenobarbital; Picrotoxin | 1958 |
[Studies on the strength of action of the analeptics bemegride, pentylenetetrazole and picrotoxin in phenobarbital-hydroxydione-ethinamate narcosis and on reciprocal antagonism].
Topics: Bemegride; Carbamates; Central Nervous System Stimulants; Hypnotics and Sedatives; Pentylenetetrazole; Phenobarbital; Picrotoxin; Pregnanediones; Stupor | 1963 |
STIMULANT ACTION OF PYRIDYL DERIVATIVES OF BENZODIOXANS AND BENZODIOXEPANS.
Topics: Animals; Anticonvulsants; Atropine; Bemegride; Central Nervous System Agents; Central Nervous System Stimulants; Chlorisondamine; Chlorpromazine; Diazepam; Mephenesin; Meprobamate; Mice; Pentylenetetrazole; Pharmacology; Phenobarbital; Phenytoin; Picrotoxin; Research; Seizures; Strychnine; Tranquilizing Agents | 1963 |
SYNTHESIS AND PHARMACOLOGICAL PROPERTIES OF PHENYL-SUBSTITUTED BIURETS.
Topics: Atropine; Biuret; Chemistry, Pharmaceutical; Gastric Juice; Meprobamate; Mice; Nicotine; Pentylenetetrazole; Peptic Ulcer; Pharmacology; Phenformin; Phenobarbital; Picrotoxin; Rats; Research; Seizures; Strychnine; Toxicology; Urea | 1963 |
Physiological and pathological spindling phenomena have similar regional EEG power distributions.
Topics: Analysis of Variance; Animals; Anticonvulsants; Brain; Convulsants; Electrodes, Implanted; Electroencephalography; Epilepsy, Generalized; Male; Phenobarbital; Picrotoxin; Rats; Rats, Inbred WKY; Rats, Sprague-Dawley; Signal Processing, Computer-Assisted; Sleep; Species Specificity | 2004 |
Quinolinic acid promotes seizures and decreases glutamate uptake in young rats: reversal by orally administered guanosine.
Topics: Administration, Oral; Aging; Animals; Animals, Newborn; Anticonvulsants; Brain; Disease Models, Animal; Dose-Response Relationship, Drug; Down-Regulation; Drug Interactions; Epilepsy; Excitatory Amino Acid Antagonists; Female; GABA Antagonists; Glutamic Acid; Guanosine; In Vitro Techniques; Injections, Intraventricular; Male; Neurons; Phenobarbital; Picrotoxin; Quinolinic Acid; Rats; Rats, Wistar | 2004 |
Effect of 7-nitroindazole alone and in combination with phenobarbitone and diazepam on picrotoxin-induced convulsions in rats.
Topics: Animals; Diazepam; Dose-Response Relationship, Drug; Drug Therapy, Combination; Indazoles; Male; Phenobarbital; Picrotoxin; Rats; Rats, Wistar; Seizures | 2003 |
The effect of L-arginine on the memory impairing action of phenobarbitone in rats that convulsed after the injection of picrotoxin.
Topics: Animals; Arginine; Male; Memory Disorders; Nitric Oxide; Phenobarbital; Picrotoxin; Rats; Rats, Wistar; Reaction Time; Seizures | 2004 |
Effects of sodium nitroprusside, a nitric oxide donor, on gamma-aminobutyric acid concentration in the brain and on picrotoxin-induced convulsions in combination with phenobarbitone in rats.
Topics: Animals; Brain; Dose-Response Relationship, Drug; Drug Combinations; gamma-Aminobutyric Acid; Male; Nitric Oxide; Nitric Oxide Donors; Nitroprusside; Phenobarbital; Picrotoxin; Rats; Rats, Wistar; Seizures | 2005 |
Stereoselective effects of the novel anticonvulsant lacosamide against 4-AP induced epileptiform activity in rat visual cortex in vitro.
Topics: 2-Amino-5-phosphonovalerate; 4-Aminopyridine; 6-Cyano-7-nitroquinoxaline-2,3-dione; Acetamides; Animals; Anticonvulsants; Carbamazepine; Convulsants; Electrophysiology; Epilepsy; Excitatory Amino Acid Antagonists; Extracellular Space; Female; In Vitro Techniques; Lacosamide; Male; Membrane Potentials; Patch-Clamp Techniques; Phenobarbital; Picrotoxin; Potassium Channel Blockers; Prohibitins; Rats; Rats, Sprague-Dawley; Synaptic Transmission; Visual Cortex | 2006 |
Diphenyl diselenide-induced seizures in rat pups: possible interaction with GABAergic system.
Topics: Acetanilides; Animals; Animals, Newborn; Benzene Derivatives; Diazepam; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; GABA Modulators; gamma-Aminobutyric Acid; Organoselenium Compounds; Phenobarbital; Picrotoxin; Rats; Seizures | 2010 |
Anticonvulsant activity of the methanolic extract of Justicia extensa T. Anders.
Topics: Acanthaceae; Animals; Anticonvulsants; Convulsants; Diazepam; Disease Models, Animal; Female; Male; Medicine, African Traditional; Methanol; Mice; Nigeria; Phenobarbital; Phytotherapy; Picrotoxin; Plant Extracts; Plant Leaves; Seizures; Solvents; Strychnine | 2011 |
WS0701: a novel sedative-hypnotic agent acting on the adenosine system.
Topics: Adenosine; Animals; Behavior, Animal; Decanoates; Frontal Lobe; Hypnotics and Sedatives; Hypothalamus; Male; Maze Learning; Mice; Phenobarbital; Picrotoxin; Pyrimidines; Rats; Rats, Sprague-Dawley; Sleep Stages; Time Factors; Triazoles | 2014 |
Shared structural mechanisms of general anaesthetics and benzodiazepines.
Topics: Allosteric Regulation; Anesthetics, General; Barbiturates; Benzodiazepines; Bicuculline; Binding Sites; Binding, Competitive; Cryoelectron Microscopy; Diazepam; Electrophysiology; Etomidate; Flumazenil; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Humans; Ligands; Models, Molecular; Molecular Conformation; Molecular Dynamics Simulation; Phenobarbital; Picrotoxin; Propofol; Receptors, GABA-A | 2020 |