picrotoxin has been researched along with pentylenetetrazole in 354 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 239 (67.51) | 18.7374 |
| 1990's | 45 (12.71) | 18.2507 |
| 2000's | 46 (12.99) | 29.6817 |
| 2010's | 17 (4.80) | 24.3611 |
| 2020's | 7 (1.98) | 2.80 |
| Authors | Studies |
|---|---|
| Cohn, M; Cohn, ML; Kraynack, BJ; Taylor, FH | 1 |
| Chimote, KV; Moghe, PJ | 1 |
| Javid, MJ; Stone, WE | 2 |
| Bernardo, K; Keenan, L; Koopowitz, H | 1 |
| Bures, J; Ueda, M | 1 |
| Georgiev, VP; Petkova, BP | 1 |
| McQueen, JK; Woodbury, DM | 1 |
| Costa, E; Guidotti, A; Mao, CC; Suria, A | 1 |
| Dinnedahl, V; Gumulka, SW; Opmeer, FA; Schönhöfer, PS | 1 |
| Dinnendahl, V; Gumulka, SW; Schönhöfer, PS | 1 |
| Matthews, WD; McCafferty, GP | 1 |
| Costa, E; Guidotti, A; Mao, CC | 1 |
| Stone, WE | 1 |
| Killam, KF; Rosenkranz, RP | 1 |
| Fukumori, R; Kitagawa, H; Minegishi, A; Nakagawa, I; Satoh, T; Yanaura, S | 1 |
| Franco, S; Schlosser, W | 1 |
| Anhut, H; Hertting, G; Steinhauer, HB | 1 |
| Barker, JL; Macdonald, RL | 1 |
| Bigler, ED | 1 |
| Gartside, IB; Hayes, AG; Straughan, DW | 1 |
| Feldberg, W; Rocha e Silva, M | 1 |
| Greenlee, D; Olsen, RW; Ticku, MK; Van Ness, PC | 1 |
| Kaplan, BJ; Williamson, PD | 1 |
| Onozuka, M; Sugaya, E | 1 |
| Andén, NE; Wachtel, H | 1 |
| Dóda, M; György, L; Koltai, MZ | 1 |
| Frey, HH; Löscher, W | 1 |
| Mulas, A; Pedata, F; Pepeu, G; Pepeu, IM | 1 |
| Cole, FR; Nelson, RB | 1 |
| Aoki, R; Nakamura, K; Suzuki, T; Uritani, K; Yajima, T | 1 |
| Conforti, N; Harel, D; Lavy, S; Raday, N | 1 |
| Borzek, G; Bures, J; von Schwarzenfeld, I | 1 |
| Peesker, SJ; Wood, JD | 1 |
| Hata, T; Kita, T; Miyake, Y; Okage, T | 1 |
| Cammelli, E; De Bellis, AM; Nistri, A | 1 |
| Dobkin, J; Lichtshtein, D | 1 |
| Nicoll, RA; Padjen, A | 1 |
| Serratosa, J; Trullas, R; Tusell, JM; Vendrell, M | 1 |
| Liu, CC; Nichols, AC; Snead, OC | 1 |
| Hume, DA; Le, F; Shanley, BC; Wilce, PA | 1 |
| Lin, WC; Watanabe, K; Yano, S | 3 |
| Serratosa, J; Tusell, JM; Vendrell, M | 2 |
| Gettins, D; Goldsack, N; Ibegbuna, V; Stanford, SC | 1 |
| Artigas, F; de Vera, N; Martínez, E | 1 |
| Araki, H; Sano, M; Shimada, C; Tanaka, S | 1 |
| Carboni, G; Corda, MG; Frau, V; Giorgi, O; Lecca, D; Orlandi, M | 1 |
| Faktorová, M; Kubová, H; Mares, P | 1 |
| Igarashi, H; Kamei, J; Kasuya, Y | 1 |
| Helton, DR; Williams, PD | 1 |
| Arnoldi, A; Bonsignori, A; Melloni, P; Merlini, L; Quadri, ML; Varasi, M | 1 |
| Biggio, G; Corda, MG; Giorgi, O; Longoni, B; Orlandi, M | 1 |
| Abdikaliev, NA; Mdzinarishvili, AL; Meerson, FZ; Pshennikova, MG; Voronina, TA | 1 |
| Becker, A; Grecksch, G; Matthies, H | 1 |
| Mares, P; Rokyta, R; Velísek, L; Velísková, J | 1 |
| Coulter, DA; Huguenard, JR; Prince, DA | 1 |
| De Barry, J; Mathis, C; Ungerer, A | 1 |
| Campbell, JA; Greenwood, TD; Rathman, TL; Sleevi, MC; Wolfe, JF | 1 |
| Kaneto, H; Miwa, T; Nakamura, J; Sasaki, H; Shibasaki, J | 1 |
| Fishman, BE; Gianutsos, G | 2 |
| Albertson, TE; Joy, RM | 1 |
| Sedlácek, J | 3 |
| Golovenko, NIa; Zhuk, OV; Zin'kovskiĭ, VG | 3 |
| Curran, T; Hempstead, J; Macgregor-Leon, PF; Mitchelmore, C; Morgan, JI; Sonnenberg, JL | 1 |
| Chang, YF; Gao, XM | 1 |
| Calder, LD; Karler, R; Murphy, V; Turkanis, SA | 1 |
| Godlevskiĭ, LS; Karganov, MIu; Kryzhanovskiĭ, GN; Lutsenko, VK; Shandra, AA | 1 |
| Bhadra, S; Idemudia, SO; Lal, H | 1 |
| Georgieva, J | 1 |
| Krsiak, M | 1 |
| Golovenko, NIa; Zhuk, OV; Zin'kovskiiĭ, VG | 1 |
| Hara, S; Morioka, S; Satoh, K; Yanagihara, S | 1 |
| Fujii, E; Nomoto, T | 1 |
| File, SE; Wilks, L | 1 |
| File, SE; Pellow, S | 1 |
| Chen, HC; Hsieh, MT; Hsu, PH; Shibuya, T | 1 |
| Kent, AP; Webster, RA | 1 |
| Anderson, MC; Chung, EY; Van Woert, MH | 1 |
| Coper, H; Herrmann, WM | 1 |
| Treit, D | 1 |
| Hutchison, AJ; Lehmann, J; McPherson, SE; Mondadori, C; Murphy, DE; Schmutz, M; Sinton, CM; Steel, DJ; Tsai, C; Williams, M | 1 |
| Bender, AS; Hertz, L | 1 |
| Durán, JA; Miñano, FJ; Sancibrián, M; Serrano, JS | 1 |
| Bourn, WM; Garrett, RL | 1 |
| Biggio, G; Corda, MG | 1 |
| Little, HJ; Nutt, DJ; Taylor, SC | 1 |
| Croucher, M; Gueremy, C; Le Fur, G; Legrand, JJ; Mazadier, M; Meldrum, B; Mizoule, J; Ollat, C; Uzan, A | 1 |
| Centra, M; Keeting, PE; Lysz, TW; Markey, K | 1 |
| Laporte, AM; Soubrié, P; Thiébot, MH | 1 |
| Kantarev, N; Parisheva, Z; Toreva, D | 1 |
| Baraban, JM; Christy, BA; Cole, AJ; Ryder, K; Saffen, DW; Worley, PF | 1 |
| Lee, M; Netzeband, JG; Strahlendorf, HK; Strahlendorf, JC | 1 |
| Crabbe, JC; Feller, DJ; Harris, RA | 1 |
| Lister, RG; Nutt, DJ | 1 |
| Bernasconi, R; Christen, P; Hafner, T; Klein, M; Martin, P; Portet, C; Schmutz, M | 1 |
| Burdette, LJ; Dyer, RS | 1 |
| Alpern, HP; McIntyre, TD | 1 |
| Piredda, SG; Swinyard, EA; Woodhead, JH | 1 |
| Hinko, CN; Lee, JA; Moore, JA; Nicholson, JM; Scott, KR; Zalucky, TB | 1 |
| Longo, VG; Sagratella, S | 1 |
| Chweh, AY; Coleman, JC; Shenoy, AK; Swinyard, EA | 1 |
| Cross, RS; Giesler, M; Nelson, SR; Pazdernik, TL; Samson, FE | 1 |
| Higashio, T; Inukai, T; Nakao, K | 1 |
| Fukuda, H; Ito, T; Watanabe, K | 1 |
| Brown, DJ; Stone, WE | 1 |
| Bhargava, KP | 1 |
| Hill, RG; Simmonds, MA; Straughan, DW | 2 |
| Owasoyo, JO; Walker, CA | 1 |
| Straughan, DW | 1 |
| Nistri, A; Pepeu, G | 1 |
| Bravo, MC; Negishi, K; Verzeano, M | 1 |
| Amato, G; Enia, F; La Grutta, V; Militello, L | 2 |
| Boyd, EH; Boyd, ES; Brown, LE | 1 |
| Brus, M; Tauberger, G | 1 |
| Vernadakis, A; Woodbury, DM | 1 |
| Cho, AK; Haslett, WL | 1 |
| Laycock, GM; Shulman, A; Wright, RD | 1 |
| Bean, JW; Thom, B; Zee, D | 1 |
| Myschetzky, A | 1 |
| Neal, MJ | 1 |
| Baxter, BL | 1 |
| Ito, M; Obata, K; Ochi, R; Sato, N | 1 |
| Byles, PH; Dobkin, AB; Su, JP | 1 |
| Chusid, JG; Kopeloff, LM | 1 |
| Kramer, RL; Lessin, AW | 1 |
| Chittal, SM; Gokhale, SV; Naik, SR | 1 |
| Buchanan, AS; Laycock, GM; Shulman, A | 1 |
| Kimura, R; Murata, T | 1 |
| Johnston, GA; Mitchell, JF | 1 |
| Osuide, G | 2 |
| Andry, ML; Luttges, MW | 1 |
| Izquierdo, I | 1 |
| Absil, J; Buchel, L | 1 |
| Eichbaum, FW; Yasaka, J | 1 |
| Araki, Y; Ueki, S | 1 |
| McGaugh, JL | 2 |
| Kazama, K | 1 |
| Radomski, MW; Watson, WJ | 1 |
| Fleming, DE; Rhodes, LE; Shearer, DE; Wilson, CE | 1 |
| Baxter, MG; Miller, AA; Webster, RA | 1 |
| Goldstein, DB | 1 |
| Yoshino, T | 1 |
| Saito, S | 1 |
| Swinyard, EA | 1 |
| Essman, WB | 1 |
| Krnjević, K; Randić, M; Straughan, DW | 1 |
| Polosa, C; Teare, JL; Wyszogrodski, I | 1 |
| Marcus, RJ; Roberts, E; Simonsen, DG; Winters, WD | 1 |
| Ban, T; Sasa, M; Shimamoto, K; Takaori, S | 1 |
| Fujiwara, M; Matsuo, S; Shimamoto, K | 1 |
| Guhlke, I; Schmidt, J | 1 |
| Elliott, KA; Yoshino, Y | 2 |
| Borbély, AA | 1 |
| Radomski, MW; Wood, JD | 1 |
| Banerjee, U; Feldberg, W; Georgiev, VP | 1 |
| Hahn, F; May, HU | 1 |
| Jaques, LB; Lucas, ON; Millar, GJ | 1 |
| Bircher, RP; Chai, CY; Rozear, M; Wang, SC | 1 |
| Bircher, RP; Tseng, DT; Wang, SC | 1 |
| Watson, WJ; Wood, JD | 1 |
| Ferngren, H | 1 |
| Adachi, S; Ishida, R; Kodama, T; Kowa, Y; Nishizawa, Y | 1 |
| Kovacs, BA; Voith, K | 1 |
| Atsev, E; Chavdarov, D; Mihailov, S; Usunoff, G | 1 |
| Hemsworth, BA; Neal, MJ | 1 |
| Hahn, F; Kretzschmar, R; Meyer, HJ | 1 |
| Iwata, H; Oka, T; Shikimi, T | 1 |
| Benuazizi, A; Irwin, S | 1 |
| Ramwell, PW; Shaw, JE | 1 |
| Kuriyama, K; Roberts, E; Rubinstein, MK | 1 |
| Boyd, ES; Gardner, LC; Meritt, DA | 1 |
| Priyatkina, TN; Sytinskii, IA | 1 |
| Bartels, E; Rosenberg, P | 1 |
| DeFeudis, FV; Elliott, KA | 1 |
| Collins, RJ; Simonton, VR | 1 |
| File, SE | 3 |
| Calder, LD; Karler, R; Sangdee, P; Turkanis, SA | 1 |
| Calder, LD; Karler, R; Turkanis, SA | 1 |
| Hamon, M; Hery, F; Jobert, A; Montastruc, JL; Soubrie, P; Thiebot, MH | 1 |
| Brahmapurikar, MT; Mateenuddin, M; Sadre, NL | 1 |
| Hara, S; Kitagawa, H; Satoh, T | 1 |
| Horisaka, K | 1 |
| Miyamoto, M; Nagawa, Y; Saji, Y; Shintani, M | 1 |
| Morag, M; Myslobodsky, MS | 1 |
| Batts, CC; Cowen, PJ; Grahame-Smith, DG; Green, AR; Nutt, DJ | 1 |
| Simmonds, MA | 1 |
| Engel, J; Liljequist, S | 1 |
| Blavet, N; DeFeudis, FV | 1 |
| Jensen, LH; Petersen, EN | 1 |
| File, SE; Green, AR; Nutt, DJ; Vincent, ND | 1 |
| Ramanjaneyulu, R; Ticku, MK | 1 |
| Mauss, EA; Wallenstein, MC | 1 |
| Fujii, T; Ikeda, H; Nonaka, C | 1 |
| Ciesielski, L; Mandel, P; Simler, S | 1 |
| Sarhan, S; Seiler, N | 1 |
| File, SE; Lister, RG | 1 |
| Crider, AM; Hinko, CN; Seibert, K | 1 |
| Barker, JL; Mathers, DA; McBurney, RN | 1 |
| Barbadoro, E; Graziani, G; Testa, R; Tirone, F | 1 |
| File, SE; Simmonds, MA | 1 |
| Kofman, O; Mintz, M; Myslobodsky, M | 1 |
| Herling, S; Winger, G | 1 |
| Ciesielski, L; Klein, M; Mandel, P; Simler, S | 1 |
| Batts, CC; Cowen, PJ; Green, AR; Heal, DJ; Nutt, DJ | 1 |
| Kalichman, MW | 1 |
| Scholfield, CN | 1 |
| Barberi, C; Carré, MC; Catau, G; Caubère, P; Jacque, M; Trocklé, G | 1 |
| Kofman, O; Mintz, M; Myslobodsky, MS | 1 |
| Golovchinsky, V; Mintz, M; Myslobodsky, MS | 1 |
| Arbabha, B; Bansinath, M; Garg, UC; Turndorf, H | 1 |
| Crichlow, EC; Kim, JS | 1 |
| Dunham, L; Guillet, R | 1 |
| Hancox, JC; Pitman, RM | 1 |
| Bolster, B; Dakshinamurti, K; Sharma, SK | 1 |
| Adachi, I; Eigyo, M; Inoue, Y; Ishibashi, C; Koyabu, K; Matsushita, A; Murata, S; Sakaguchi, I; Shiomi, T; Ueda, M | 1 |
| Freeman, P; Meade, HM; Seeley, NA; Sturman, G | 1 |
| Komatsu, H; Nogaya, J; Ogli, K; Ueki, M; Yokono, S | 1 |
| Pomés, A; Rodríguez-Farré, E; Suñol, C | 1 |
| Getova, DP; Maslarova, JE; Nikolov, RK; Semkova, IS | 1 |
| Cannizzaro, C; Cannizzaro, G; Flugy, A; Gagliano, M; Sabatino, M | 1 |
| Dorce, VA; Sandoval, MR | 1 |
| Mares, P; Micianiková, D; Rokyta, R; Velísek, L; Velísková, J | 1 |
| Bassareo, V; Di Chiara, G; Giua, C; Petromilli, P; Tanda, G | 1 |
| Endo, T; Hara, S; Iwata, N; Kano, S; Kuriiwa, F; Mukai, T | 1 |
| Camón, L; de Vera, N; Giménez-Llort, L; Martínez, E | 1 |
| Miyakawa, T; Niki, H; Tateishi, K; Yagi, T | 1 |
| Lin, WC | 1 |
| Chang, CC; Chiou, LC; Ling, JY | 1 |
| Badran, S; Olpe, HR; Schmutz, M | 1 |
| Alexander, CB; Ellmore, TM; Kirkby, RD; Kokate, TG | 1 |
| Balestra, M; Borrelli, AR; Cramer, CL; Eismann, MS; Freedman, LR; Hudzik, TJ; Knowles, MK; Mahmood, N; McCarthy, DJ; Murray, RJ; Palmer, GC; Stagnitto, ML | 1 |
| Kim, DC; Todd, MM | 1 |
| Bijak, M; Chojnacka-Wójcik, E; Czuczwar, SJ; Kroczka, B; Kłodzińska, A; Pilc, A; Swiader, M | 1 |
| Chae, WG; Choi, H; Choi, J; Jahng, Y; Je, SM; Kim, EK; Kim, TH; Kim, YC; Lee, ES; Park, M; Zhao, LX | 1 |
| Atapour, N; Kalantaripour, TP; Niazi, M; Nourpanah, M | 1 |
| Bell-Horner, CL; Covey, DF; Dibas, MI; Dillon, GH; Drewe, JA; Huang, RQ | 1 |
| Choudhary, MI; DeLorenzo, RJ; Rahman, AU; Raza, M; Shaheen, F; Sombati, S; Suria, A | 1 |
| Choudhary, MI; DeLorenzo, RJ; Rafiq, A; Rahman, A; Raza, M; Shaheen, F; Sombati, S; Suria, A | 1 |
| Amabeoku, GJ; Bienvenu, E; Eagles, PK; Scott, G; Springfield, EP | 1 |
| Chopde, CT; Kasture, SB; Kasture, VS | 1 |
| Koryntová, H; Kubová, H; Mares, P; Tutka, P | 1 |
| Dubé, C; Koning, E; Nehlig, A | 1 |
| Chaichantipyuth, C; Matsumoto, K; Murakami, Y; Sukma, M; Tohda, M; Watanabe, H | 1 |
| Bell-Horner, CL; Das, P; Dillon, GH; Machu, TK | 1 |
| Goncharenko, NV; Pankrat'ev, DV; Talalaenko, AN | 1 |
| Carvalho, JC; Carvalho, JE; Perazzo, FF; Rehder, VL | 1 |
| BURGERMEISTER-GUEX, G; DUCOMMUN, M; FROMMEL, E; RADOUCO-THOMAS, C | 1 |
| SANTARATO, R | 1 |
| BEANI, L; PEPEU, GC | 1 |
| ANDERSON, WR; TEAGUE, RS | 1 |
| KIMURA, ET; RICHARDS, RK | 1 |
| ALEMA, G; SERGIO, C | 1 |
| HAHN, F; OBERDORF, A | 3 |
| DOBKIN, AB | 1 |
| BIRCHER, RP; KANAI, T; WANG, SC | 2 |
| HAHN, F; HEIDENREICH, O; OBERDORF, A | 1 |
| MAGISTRETTI, MJ; MURMANN, W; SETNIKAR, I | 2 |
| SETNIKAR, I | 1 |
| WATANABE, A; YUASA, T | 1 |
| COPINSCHI, G; CORNIL, A; THYS, O | 1 |
| CARTER, SH; ROA, PD; STONE, WE; TEWS, JK | 1 |
| ECCLES, JC; SCHMIDT, R; WILLIS, WD | 1 |
| DELWAIDE, PJ; DESMEDT, JE | 1 |
| BERITIC, T | 1 |
| SIGG, EB; WARNER, CL; YEN, HC | 1 |
| ADRIANI, J; MULLEN, J | 1 |
| IZAR, G | 1 |
| CHUBB, FL; HAJDU, A; KOMLOSSY, J; LEE, CF; MCCOLL, JD | 1 |
| FISCHER, R; LISS, L; SOLZE, DA | 1 |
| MEYER, HJ | 1 |
| MAGISTRETTI, MJ; SETNIKAR, I | 1 |
| LAYCOCK, GM; SHANKLY, KH; SHULMAN, A; WRIGHT, RD | 1 |
| JOHNSON, WL; O'LEARY, JL | 1 |
| BIRCHER, RP; CHAI, CY; WANG, SC | 1 |
| HAHN, F; MEYER, HJ | 1 |
| CAMPANA, C; CARDINALI, G | 1 |
| Fei, J; Guo, LH; Ma, YH; Mei, ZT; Zhao, WJ | 1 |
| Bureau, Y; McIntyre, DC; Racine, RJ; Steingart, M | 1 |
| BURGOS, MH | 1 |
| Ha, JH; Koo, BS; Lee, DU; Lee, SI | 1 |
| Reddy, DS | 1 |
| Ojewole, JA | 4 |
| Araújo, DA; Cruz, JS; de Almeida, RN; de Sousa, DP; Gonçalves, JC; Quintans-Júnior, L | 1 |
| Amabeoku, GJ; Ojewole, JA | 1 |
| Chouinard, SW; Littleton, JT; Saraswati, S; Stilwell, GE | 1 |
| Gütschow, M; Kubacka, M; Librowski, T; Meusel, M; Müller, CE; Scolari, S | 1 |
| Blank, M; Fernandez, F; Garner, CC; Malenka, RC; Morishita, W; Nguyen, J; Zuniga, E | 1 |
| Amabeoku, GJ; Green, I; Kabatende, J | 1 |
| Choi, D; Harris, RH; Kohn, H; Kupferberg, HJ; Stables, JP; Stöhr, T; Walton, N; White, HS | 1 |
| Kubová, H; Mares, P; Tchekalarova, J | 1 |
| Buckley, F; Sacks, B | 1 |
| Akula, KK; Dhir, A; Kulkarni, SK | 1 |
| Alves, PB; Antoniolli, AR; Blank, AF; Bonjardim, LR; Leite, BS; Lessa, NM; Quintans-Júnior, LJ; Santos, MR; Souza, TT | 1 |
| Andreev, AA; Kalinina, MV; Karpova, MN; Klishina, NY; Kuznetsova, LV; Rebrov, IG | 1 |
| Pericić, D; Strac, DS; Vlainić, J | 1 |
| Choi, SY; Choi, UK; Kang, JH; Kang, TC; Kim, DW; Kim, HT; Kim, JE; Kwak, SE; Kwon, OS; Lee, SJ | 1 |
| Albert, GW; Howard, MA; Schnizler, MK; Severson, MA; Welsh, MJ; Wemmie, JA; Ziemann, AE | 1 |
| Araújo, DA; Claudino, Fde S; de Almeida, RN; de Sousa, DP; Leite, JR; Mattei, R; Nóbrega, FF | 1 |
| GESSNER, O | 1 |
| Jain, R; Kaur, N; Krishnamoorthy, S; Meena, CL; Monga, V; Pawar, C; Rajput, SK; Sharma, SS | 1 |
| Barth, AL; Benedetti, BL; Sheehan, JJ | 1 |
| Bailabar, T; Bum, EN; Hiana, IR; Moto, FC; Nkainsa, LA; Rakotonirina, A; Rakotonirina, SV; Seke Etet, PF; Seyni, P; Taiwe, GS | 1 |
| Amabeoku, G | 1 |
| Shalini, M; Sriram, D; Stables, JP; Yogeeswari, P | 1 |
| Nwafor, PA; Okokon, JE | 1 |
| Ingole, S; Jain, G; Jain, R; Kaur, N; Meena, CL; Monga, V; Rajput, SK; Sharma, SS; Singh, JN | 1 |
| Araki, H; Kawasaki, H; Ochi, R; Suemaru, K | 1 |
| Ahmad, M; Raza, ML; Shaheen, F; Simjee, SU; Zeeshan, M | 1 |
| HUIDOBRO, F | 1 |
| Cachat, J; Chang, K; Dileo, J; Frank, K; Gaikwad, S; Gilder, T; Grossman, L; Kalueff, AV; Stewart, A; Suciu, C; Utterback, E; Wong, K; Wu, N | 1 |
| de Freitas, RM; Feng, D; Silva, Fde O; Silva, MG | 1 |
| Citó, AM; de Almeida, AA; de Freitas, RM; Júnior, JS; Saffi, J; Tomé, Ada R | 1 |
| Banks, CN; Bruun, DA; Dhir, A; Hammock, BD; Inceoglu, B; Lein, PJ; McCoy, MR; Rogawski, MA; Sanborn, JR; Zolkowska, D | 1 |
| Aslan, M; Deliorman Orhan, D; Orhan, IE; Orhan, N; Süküroğlu, M | 1 |
| Baxendale, S; Cunliffe, VT; Fox, J; Harrison, MR; Holdsworth, CJ; Ingham, PW; Meza Santoscoy, PL; Parkin, CA | 1 |
| Dhir, A; Rogawski, MA; Zolkowska, D | 1 |
| Aguiar, CC; Almeida, AB; Araújo, PV; Chaves, EM; de Barros Viana, GS; do Vale, OC; Leal, LK; Macêdo, DS; Vasconcelos, GS; Vasconcelos, SM | 1 |
| Ahangar, N; Ebrahimzadeh, MA; Nabavi, SF; Nabavi, SM | 1 |
| Bennett, CF; Chen, G; Cirrito, JR; DeVos, SL; Goncharoff, DK; Holtzman, DM; Kebodeaux, CS; Maloney, SE; Miller, TM; Rigo, F; Schuler, DR; Stewart, FR; Wozniak, DF; Yamada, K | 1 |
| Alhumayyd, MS; Bukhari, IA; Gilani, AH; Mahesar, AL; Pivac, N | 1 |
| Kubová, H; Mareš, P | 1 |
| Al-Obaid, AM; Al-Salem, HS; El-Messery, SM; El-Subbagh, HI; El-Taher, KE; Hegazy, GH | 1 |
| Cao, L; Di, ZL; Jiang, Y; Lei, H; Tian, Y; Zhang, GJ | 1 |
| Deepakumari, HN; Jayanna, BK; Prashanth, MK; Revanasiddappa, HD; Veeresh, B | 1 |
| Dunn, RL; Feng, Y; Forcelli, PA; Hammack, RJ; Huizenga, MN; Pak, DTS; Queenan, BN; Santos, VR; Vicini, S | 1 |
| Bandara, SB; Carty, DR; Harvey, DJ; Lein, PJ; Pressly, B; Singh, V; Vasylieva, N; Wulff, H | 1 |
| Chen, Y; Deng, J; He, M; Li, R; Wu, B; Yuan, J; Zhang, P; Zhang, Q | 1 |
| Carmona-Aparicio, L; González-Trujano, ME; Martínez-Vargas, D; Santos-Valencia, F; Urbina-Trejo, E; Villasana-Salazar, B | 1 |
| Chouna, R; Dongmo, AK; Fokoua, AR; Kaptué Wuyt, A; Ndjenda, MK; Nguelefack, TB; Nkeng-Efouet, PA; Tatsinkou Bomba, FD | 1 |
| Adeyemi, OO; Afolayan, O; Ajayi, AM; Ben-Azu, B; Ishola, IO; James, AB; Nwose, E; Olubodun-Obadun, TG; Umukoro, S | 1 |
| Georgiyants, V; Kayal, WE; Mishchenko, M; Severina, H; Shtrygol, D; Shtrygol, S; Zalevskyi, S | 1 |
| Adassi, MB; Foutsop, AF; Kom, TD; Ngo Bum, E; Ngoupaye, GT; Yassi, FB | 1 |
10 review(s) available for picrotoxin and pentylenetetrazole
| Article | Year |
|---|---|
New concepts on the mechanism of action of benzodiazepines.
Topics: Animals; Benzodiazepines; Cerebellum; Chlordiazepoxide; Cyclic AMP; Diazepam; gamma-Aminobutyric Acid; Ganglia, Autonomic; Glycine; Humans; Isoniazid; Medulla Oblongata; Pentylenetetrazole; Phenobarbital; Phenytoin; Picrotoxin; Receptors, Drug; Seizures; Sensory Receptor Cells; Spinal Cord; Strychnine; Substantia Nigra | 1975 |
Chronic administration of negative modulators produces chemical kindling and GABAA receptor down-regulation.
Topics: Animals; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Carbolines; Convulsants; Down-Regulation; Kindling, Neurologic; Pentylenetetrazole; Picrotoxin; Receptors, GABA-A; Sulfur Radioisotopes | 1990 |
Are nootropics a separate class of drugs? A differentiation in various models.
Topics: Aged; Amphetamine; Animals; Brain; Central Nervous System Stimulants; Humans; Pentylenetetrazole; Picrotoxin; Piracetam | 1987 |
[2 types of effects of convulsants on the embryonic CNS].
Topics: Animals; Bicuculline; Central Nervous System; Chick Embryo; Convulsants; Methionine Sulfoximine; Movement; Oxotremorine; Penicillins; Pentylenetetrazole; Picrotoxin; Strychnine; Tetanus Toxin | 1985 |
Drug facilitation of learning and memory.
Topics: Amphetamine; Animals; Bemegride; Discrimination Learning; Guinea Pigs; Learning; Memory; Nicotine; Parasympathomimetics; Pemoline; Pentylenetetrazole; Picrotoxin; Rats; RNA; Strychnine; Time Factors | 1973 |
[Biochemistry of epilepsy].
Topics: Acetylcholine; Aminobutyrates; Animals; Brain; Electroencephalography; Epilepsy; Glutamates; Glutamine; Humans; Muscle Cramp; Pentylenetetrazole; Picrotoxin; Seizures | 1968 |
Laboratory evaluation of antiepileptic drugs. Review of laboratory methods.
Topics: Animals; Anticonvulsants; Biological Assay; Brain Injuries; Diagnosis; Electroconvulsive Therapy; Electroshock; Humans; Methionine Sulfoximine; Methods; Pentylenetetrazole; Phenobarbital; Phenytoin; Picrotoxin; Seizures; Strychnine; Thiosemicarbazones; Trimethadione; Urea | 1969 |
Drug effects and learning and memory processes.
Topics: Amines; Amphetamine; Animals; Caffeine; Catecholamines; Hypnotics and Sedatives; Indoles; Learning; Macromolecular Substances; Magnesium; Malonates; Memory; Nicotine; Nitriles; Parasympathetic Nervous System; Pemoline; Pentylenetetrazole; Picrotoxin; RNA; Strychnine; Tranquilizing Agents; Uric Acid | 1971 |
Changes in CNS sensitivity to cannabinoids with repeated treatment: tolerance and auxoesthesia.
Topics: Animals; Brain; Cannabidiol; Cannabinoids; Dronabinol; Drug Tolerance; Electroshock; Kindling, Neurologic; Mice; Pentylenetetrazole; Phenytoin; Picrotoxin; Seizures | 1984 |
[TREATMENT OF ACUTE BARBITURATE POISONING].
Topics: Amphetamine; Amphetamines; Barbiturates; Bemegride; Coma; Humans; Nikethamide; Pentylenetetrazole; Picrotoxin; Resuscitation; Strychnine; Toxicology | 1963 |
344 other study(ies) available for picrotoxin and pentylenetetrazole
| Article | Year |
|---|---|
Comparisons between the antianesthetic action of dibutyryl cyclic AMP and analeptic drugs on amobarbital-induced narcosis in the rat.
Topics: Amobarbital; Amphetamines; Anesthetics; Animals; Benzamides; Bucladesine; Caffeine; Central Nervous System Stimulants; Doxapram; Male; Pentylenetetrazole; Picrotoxin; Rats; Strychnine; Theophylline | 1976 |
Putative neurotransmitters in CNS and chemoconvulsions.
Topics: Animals; Bemegride; Catecholamines; Central Nervous System; Female; Male; Mice; Neurotransmitter Agents; Pentylenetetrazole; Picrotoxin; Procaine; Seizures; Strychnine | 1977 |
Benzodiazepines and phenobarbital as antagonists of dissimilar chemical convulsants.
Topics: 3-Mercaptopropionic Acid; Animals; Anti-Anxiety Agents; Anticonvulsants; Bicuculline; Chlordiazepoxide; Convulsants; Diazepam; gamma-Aminobutyric Acid; Isoniazid; Male; Mice; Nitrazepam; Pentylenetetrazole; Phenobarbital; Picrotoxin; Therapeutic Equivalency | 1978 |
Primitive nervous systems: action of aminergic drugs and blocking agents on activity in the ventral nerve cord of the flatworm Notoplana acticola.
Topics: Animals; Bicuculline; Electric Stimulation; Evoked Potentials; gamma-Aminobutyric Acid; Glycine; Neurons; Neurotransmitter Agents; Pentylenetetrazole; Peripheral Nerves; Picrotoxin; Platyhelminths | 1979 |
Differential effects of cortical speading depression on epileptic foci induced by various convulsants.
Topics: Animals; Cerebral Cortex; Convulsants; Cortical Spreading Depression; Electroencephalography; Male; Penicillin G; Pentylenetetrazole; Picrotoxin; Potassium; Rats; Seizures; Spironolactone; Strychnine | 1977 |
Effect of p-chlorophenylalanine on the central nervous excitability threshold and on the activity of some central depressants.
Topics: Animals; Central Nervous System; Depression, Chemical; Fenclonine; Hypnotics and Sedatives; Injections, Intraperitoneal; Injections, Intravenous; Male; Mice; Pentylenetetrazole; Phenobarbital; Phenylacetates; Picrotoxin; Seizures; Strychnine; Time Factors; Toluene; Urea | 1975 |
Attempts to produce spike-and-wave complexes in the electrocorticogram of the rat.
Topics: Animals; Cerebral Cortex; Cobalt; Disease Models, Animal; Electrodes, Implanted; Electroencephalography; Estrogens, Conjugated (USP); Fluoroacetates; Male; Methionine Sulfoximine; Pentylenetetrazole; Picrotoxin; Rats; Seizures | 1975 |
Effects of stimulatory and depressant drugs on cyclic guanosine 3',5'-monophosphate and adenosine 3',5'-monophosphate levels in mouse brain.
Topics: Animals; Atropine; Brain; Brain Chemistry; Convulsants; Cyclic AMP; Cyclic GMP; Diazepam; Drug Interactions; gamma-Aminobutyric Acid; Harmaline; Male; Mice; Oxotremorine; Pentobarbital; Pentylenetetrazole; Picrotoxin; Tremor | 1976 |
Baclofen and cerebellar cyclic GMP levels in mice.
Topics: Animals; Arecoline; Baclofen; Cerebellum; Cyclic GMP; Dose-Response Relationship, Drug; gamma-Aminobutyric Acid; Isoniazid; Male; Mice; Motor Activity; Pentylenetetrazole; Picrotoxin | 1979 |
Anticonvulsant activity of muscimol against seizures induced by impairment of GABA-mediated neurotransmission.
Topics: Animals; Anticonvulsants; Bicuculline; gamma-Aminobutyric Acid; Isoniazid; Male; Muscimol; Oxazoles; Pentylenetetrazole; Picrotoxin; Rats; Seizures; Strychnine; Synaptic Transmission | 1979 |
Evidence for an involvement of GABA in the mediation of the cerebellar cGMP decrease and the anticonvulsant action diazepam.
Topics: Aminobutyrates; Animals; Anti-Anxiety Agents; Anticonvulsants; Barbiturates; Cerebellum; Cyclic AMP; Cyclic GMP; Diazepam; Drug Interactions; gamma-Aminobutyric Acid; Isoniazid; Male; Pentylenetetrazole; Phenytoin; Picrotoxin; Rats; Strychnine | 1975 |
Effects of alterations in the metabolism of gamma-aminobutyrate on convulsant potencies.
Topics: 3-Mercaptopropionic Acid; Aminobutyrates; Aminooxyacetic Acid; Animals; Bicuculline; Diacetyl; Drug Synergism; gamma-Aminobutyric Acid; Glycine; Hydrazines; Male; Mice; Pentylenetetrazole; Phenelzine; Picrotoxin; Pyridoxine; Reaction Time; Seizures; Thiones; Valproic Acid | 1977 |
Effects of intracerebroventricular administration of prostaglandins E1 and E2 on chemically induced convulsions in mice.
Topics: Animals; Anticonvulsants; Dose-Response Relationship, Drug; Injections, Intraventricular; Isoniazid; Male; Mice; Pentylenetetrazole; Picrotoxin; Prostaglandins E; Seizures; Strychnine | 1979 |
Effect of tryptophol on pentylenetetrazol and picrotoxin induced convulsion in mice.
Topics: Animals; Anticonvulsants; Brain; Indoles; Male; Mice; Mice, Inbred ICR; Pentylenetetrazole; Phenytoin; Picrotoxin; Seizures | 1979 |
Reduction of gamma-aminobutyric acid (GABA)-mediated transmission by a convulsant benzodiazepine.
Topics: Animals; Benzodiazepinones; Bicuculline; Cats; Convulsants; Female; gamma-Aminobutyric Acid; Male; Mice; Muscimol; Pentylenetetrazole; Picrotoxin; Reflex; Spinal Cord; Strychnine | 1979 |
The synthesis of prostaglandins and thromboxane in the mouse brain in vivo. Influence of drug induced convulsions, hypoxia and the anticonvulsants trimethadione and diazepam.
Topics: Animals; Brain; Diazepam; In Vitro Techniques; Male; Mice; Oxazoles; Oxygen; Pentylenetetrazole; Picrotoxin; Prostaglandins; Seizures; Thromboxanes; Time Factors; Trimethadione | 1979 |
Specific antagonism of GABA-mediated postsynaptic inhibition in cultured mammalian spinal cord neurons: a common mode of convulsant action.
Topics: Amino Acids; Aminobutyrates; Animals; Bicuculline; Convulsants; Culture Techniques; gamma-Aminobutyric Acid; Iontophoresis; Mice; Neural Inhibition; Neurons; Penicillins; Pentylenetetrazole; Picrotoxin; Spinal Cord | 1978 |
Comparison of effects of bicuculline, strychnine, and picrotoxin with those of pentylenetetrazol on photically evoked afterdischarges.
Topics: Animals; Bicuculline; Dose-Response Relationship, Drug; Electroencephalography; Isoquinolines; Light; Pentylenetetrazole; Picrotoxin; Rats; Seizures; Strychnine; Visual Cortex | 1977 |
Effect of four convulsants on the time course of presynaptic inhibition and the relation to seizure activity.
Topics: Animals; Bemegride; Bicuculline; Cerebral Cortex; Convulsants; Instinct; Male; Medulla Oblongata; Neural Inhibition; Pentylenetetrazole; Picrotoxin; Rats; Seizures | 1977 |
Vasopressin release produced in anaesthetized cats by antagonists of gamma-aminobutyric acid and glycine.
Topics: Aminobutyrates; Anesthesia; Animals; Bicuculline; Blood Pressure; Cats; GABA Antagonists; Glycine; Medulla Oblongata; Pentylenetetrazole; Picrotoxin; Strychnine; Time Factors; Tubocurarine; Vasopressins | 1978 |
Effects of drugs on gamma-aminobutyric acid receptors, uptake, release and synthesis in vitro.
Topics: Aminobutyrates; Animals; Astacoidea; Bicuculline; Brain; Diazepam; gamma-Aminobutyric Acid; Haloperidol; Imipramine; In Vitro Techniques; Male; Mice; Penicillin G; Pentylenetetrazole; Picrotoxin; Receptors, Drug; Synaptosomes | 1978 |
Electroencephalogram and somatosensory evoked potential changes after administration of six convulsant drugs.
Topics: Animals; Bemegride; Bicuculline; Cats; Convulsants; Electroencephalography; Evoked Potentials; Glycine; Pentylenetetrazole; Picrotoxin; Somatosensory Cortex; Strychnine; Time Factors | 1978 |
Intracellular calcium: its movement during pentylenetetrazole-induced bursting activity.
Topics: Action Potentials; Animals; Calcium; Electron Probe Microanalysis; Magnesium; Neurons; Pentylenetetrazole; Picrotoxin; Snails; Strychnine | 1978 |
Motor activity of rats following intracerebral injections of drugs influencing GABA mechanisms.
Topics: Aminobutyrates; Animals; Apomorphine; Corpus Striatum; Dose-Response Relationship, Drug; gamma-Aminobutyric Acid; Habituation, Psychophysiologic; Hydroxybutyrates; Injections; Male; Motor Activity; Nucleus Accumbens; Pentylenetetrazole; Picrotoxin; Rats; Reserpine; Strychnine | 1978 |
Effects of phenytoin on sympathetic reflex responses in the cat.
Topics: Animals; Blood Pressure; Cats; Dimethylphenylpiperazinium Iodide; Evoked Potentials; Female; In Vitro Techniques; Male; Nictitating Membrane; Ouabain; Pentylenetetrazole; Phenytoin; Picrotoxin; Reflex; Scopolamine; Sympathetic Nervous System | 1978 |
Di-n-propylacetic acid--profile of anticonvulsant activity in mice.
Topics: Animals; Anticonvulsants; Bicuculline; Dose-Response Relationship, Drug; Electroshock; Ethosuximide; Female; Male; Mice; Pentylenetetrazole; Phenobarbital; Picrotoxin; Seizures; Strychnine; Trimethadione; Valerates; Valproic Acid | 1976 |
Changes in regional brain acetylcholine levels during drug-induced convulsions.
Topics: Acetylcholine; Animals; Bicuculline; Brain Chemistry; Male; Pentylenetetrazole; Picrotoxin; Rats; Seizures; Strychnine | 1976 |
The convulsive profile of Cicuta douglasii (water hemlock).
Topics: Animals; Anticonvulsants; Convulsants; Electroshock; Male; Mice; Pentylenetetrazole; Phenobarbital; Phenytoin; Picrotoxin; Plant Extracts | 1976 |
[Pharmacological effects of clonazepam, an anticonvulsant, on the central nervous system].
Topics: Age Factors; Animals; Anticonvulsants; Behavior, Animal; Benzodiazepinones; Cats; Central Nervous System; Clonazepam; Dogs; Drug Synergism; Electroencephalography; Evoked Potentials; Female; Gallamine Triethiodide; Locomotion; Male; Mice; Muscle Relaxants, Central; Parasympatholytics; Pentylenetetrazole; Picrotoxin; Rats; Reflex; Sex Factors; Spinal Cord | 1976 |
Analysis of preseizure electrocorticographic changes in rats during hyperbaric oxygenation.
Topics: Animals; Diagnosis, Computer-Assisted; Electroencephalography; Hyperbaric Oxygenation; Male; Oxygen; Pentylenetetrazole; Picrotoxin; Rats; Seizures | 1975 |
Blockage of cortical spreading depression by picrotoxin foci of paroxysmal activity.
Topics: Animals; Brain; Cerebral Cortex; Cortical Spreading Depression; Electroencephalography; Pentylenetetrazole; Picrotoxin; Potassium; Potassium Chloride; Rats; Seizures; Tubocurarine | 1975 |
The anticonvulsant action of GABA-elevating agents: a re-evaluation.
Topics: Allyl Compounds; Aminobutyrates; Aminooxyacetic Acid; Animals; Anticonvulsants; Brain; Drug Evaluation, Preclinical; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Hydrazines; Hydroxylamines; Hyperbaric Oxygenation; Isoniazid; Male; Mice; Pentylenetetrazole; Picrotoxin; Seizures; Stimulation, Chemical; Time Factors | 1975 |
[Relation of time of administration of drugs to their acute toxicity to experimental animals].
Topics: Animals; Aspartic Acid; Chlorpromazine; Circadian Rhythm; Convulsants; Hexobarbital; Male; Mice; Pentylenetetrazole; Picrotoxin; Strychnine | 1975 |
Drug-induced changes in behaviour and ganglionic acetylcholine concentration of the leech.
Topics: Acetylcholine; Animals; Behavior, Animal; Ethanol; Ether; Ganglia; In Vitro Techniques; Leeches; Muscle Contraction; Oxotremorine; Pentylenetetrazole; Physostigmine; Picrotoxin; Scopolamine; Strychnine | 1975 |
Reduction of gamma-aminobutyric acid level in the cat cerebral cortex by afferent electrical stimulation.
Topics: Aminobutyrates; Animals; Brachial Plexus; Cats; Cerebral Cortex; Electric Stimulation; Female; gamma-Aminobutyric Acid; Male; Pentylenetetrazole; Picrotoxin | 1976 |
Pentylenetetrazol: an antagonist of GABA at primary afferents of the isolated frog spinal cord.
Topics: Alanine; Aminobutyrates; Animals; Evoked Potentials; GABA Antagonists; In Vitro Techniques; Neurons; Neurons, Afferent; Pentylenetetrazole; Picrotoxin; Spinal Cord; Synapses; Taurine | 1976 |
Lindane-induced convulsions in NMRI and OF1 mice: antagonism with (+)MK-801 and voltage-dependent calcium channel blockers.
Topics: Animals; Anticonvulsants; Calcium Channel Blockers; Convulsants; Dizocilpine Maleate; Dose-Response Relationship, Drug; Hexachlorocyclohexane; Male; Mice; Mice, Inbred Strains; N-Methylaspartate; Nifedipine; Pentylenetetrazole; Picrotoxin; Seizures; Sesterterpenes; Species Specificity | 1992 |
gamma-Hydroxybutyric acid binding sites: interaction with the GABA-benzodiazepine-picrotoxin receptor complex.
Topics: Animals; Brain; gamma-Aminobutyric Acid; Male; Pentobarbital; Pentylenetetrazole; Picrotoxin; Rats; Rats, Inbred Strains; Receptors, GABA-A; Sodium Oxybate; Synaptic Membranes | 1992 |
Involvement of gamma-aminobutyric acid and N-methyl-D-aspartate receptors in the inhibitory effect of ethanol on pentylenetetrazole-induced c-fos expression in rat brain.
Topics: Animals; Azides; Benzodiazepines; Brain; Ethanol; Male; N-Methylaspartate; Pentylenetetrazole; Picrotoxin; Proto-Oncogene Proteins c-fos; Rats; Rats, Wistar; Receptors, GABA-A; Receptors, N-Methyl-D-Aspartate; RNA, Messenger | 1992 |
Involvement of central GABAA receptor complex in controlling the basal gastric secretory activity in pylorus-ligated rats.
Topics: Analysis of Variance; Anesthesia; Animals; Bicuculline; Diazepam; Gastric Acid; Male; Pentobarbital; Pentylenetetrazole; Picrotoxin; Rats; Rats, Wistar; Receptors, GABA-A | 1992 |
c-fos expression as a model for studying the action of hexachlorocyclohexane isomers in the CNS.
Topics: Animals; Blotting, Northern; Brain; Hexachlorocyclohexane; Immunohistochemistry; Isomerism; Male; Nucleic Acid Hybridization; Pentylenetetrazole; Picrotoxin; Proto-Oncogene Proteins c-fos; Rats | 1992 |
Effect of gamma-hexachlorocyclohexane and its isomers on proto-oncogene c-fos expression in brain.
Topics: Animals; Blotting, Northern; Brain; Gene Expression; Genes, fos; Hexachlorocyclohexane; Male; Nucleic Acid Hybridization; Pentylenetetrazole; Picrotoxin; Rats; Rats, Inbred Strains; Stereoisomerism | 1992 |
Effects of GABAA receptor ligands on noradrenaline concentration and beta-adrenoceptor binding in mouse cerebral cortex.
Topics: Alkaloids; Animals; Azepines; Cerebral Cortex; Chlorides; Heterocyclic Compounds, 4 or More Rings; Heterocyclic Compounds, Bridged-Ring; Ion Channels; Kinetics; Lactones; Male; Mice; Neuromuscular Depolarizing Agents; Norepinephrine; Pentylenetetrazole; Picrotoxin; Piperidines; Receptors, Adrenergic, beta; Receptors, GABA-A; Yohimbine | 1990 |
Differential response of rat brain polyamines to convulsant agents.
Topics: Animals; Biogenic Polyamines; Body Weight; Brain; Convulsants; Hexachlorocyclohexane; Kainic Acid; Male; Ornithine Decarboxylase; Pentylenetetrazole; Picrotoxin; Putrescine; Rats; Rats, Inbred Strains; Sesterterpenes; Spermidine; Spermine | 1991 |
[Drug-induced seizures in taurine-deficient mice].
Topics: Amino Acids; Animals; Brain Chemistry; Female; gamma-Aminobutyric Acid; Male; Mice; Mice, Inbred ICR; Pentylenetetrazole; Picrotoxin; Seizures; Strychnine; Taurine | 1991 |
Pentylenetetrazol-induced kindling in rats: effect of GABA function inhibitors.
Topics: Animals; Azides; Benzodiazepines; Carbolines; GABA Antagonists; Isoniazid; Kindling, Neurologic; Male; Pentylenetetrazole; Picrotoxin; Rats; Rats, Inbred Strains; Seizures; Strychnine | 1991 |
Effect of phenobarbital on motor seizures elicited by picrotoxin and bicuculline in rats.
Topics: Animals; Bicuculline; Male; Pentylenetetrazole; Phenobarbital; Picrotoxin; Rats; Rats, Inbred Strains; Seizures | 1991 |
Modulation by serotonin of glutamate-induced lethality in mice.
Topics: 5-Hydroxytryptophan; 8-Hydroxy-2-(di-n-propylamino)tetralin; alpha-Methyltyrosine; Analysis of Variance; Animals; Brain; Fenclonine; Male; Methyltyrosines; Mice; N-Methylaspartate; Pentylenetetrazole; Picrotoxin; Piperazines; Reserpine; Serotonin; Sodium Glutamate; Strychnine; Tetrahydronaphthalenes; Tryptophan | 1991 |
The proconvulsive activity of quinolone antibiotics in an animal model.
Topics: Animals; Anti-Infective Agents; Convulsants; Dose-Response Relationship, Drug; Male; Mice; Mice, Inbred Strains; Nalidixic Acid; Oxolinic Acid; Pentylenetetrazole; Picrotoxin; Seizures; Strychnine | 1991 |
Synthesis and anticonvulsant activity of some benzopyranone imino derivatives of GABA and related compounds.
Topics: 3-Mercaptopropionic Acid; Animals; Anticonvulsants; Bicuculline; Chromans; gamma-Aminobutyric Acid; Imines; Male; Mice; Mice, Inbred ICR; Mice, Inbred Strains; Pentylenetetrazole; Picrotoxin; Rats | 1991 |
[Comparative evaluation of anticonvulsant and anti-arrhythmic effects of phenazepam, a benzodiazepine receptor agonist].
Topics: Animals; Anti-Anxiety Agents; Anti-Arrhythmia Agents; Anticonvulsants; Benzodiazepines; Benzodiazepinones; Bicuculline; Heart; Male; Mice; Pentylenetetrazole; Picrotoxin; Rats; Rats, Inbred Strains; Thiosemicarbazones | 1990 |
Threshold to elicit seizures by picrotoxin is lowered in pentylenetetrazol-kindled mice.
Topics: Animals; Kindling, Neurologic; Male; Mice; Mice, Inbred ICR; Pentylenetetrazole; Picrotoxin; Seizures | 1990 |
Ketamine suppresses both bicuculline- and picrotoxin-induced generalized tonic-clonic seizures during ontogenesis.
Topics: Aging; Animals; Ataxia; Bicuculline; Ketamine; Male; Pentylenetetrazole; Picrotoxin; Rats; Rats, Inbred Strains; Seizures | 1990 |
Differential effects of petit mal anticonvulsants and convulsants on thalamic neurones: GABA current blockade.
Topics: Animals; Anticonvulsants; Bicuculline; Convulsants; Epilepsy, Absence; Ethosuximide; gamma-Aminobutyric Acid; In Vitro Techniques; Iontophoresis; Neurons; Pentylenetetrazole; Picrotoxin; Rats; Succinimides; Thalamus | 1990 |
NMDA antagonist properties of gamma-L-glutamyl-L-aspartate demonstrated on chemically induced seizures in mice.
Topics: Animals; Anticonvulsants; Behavior, Animal; Dipeptides; Dose-Response Relationship, Drug; Injections, Intraventricular; Kainic Acid; Male; Mice; N-Methylaspartate; Pentylenetetrazole; Picrotoxin; Quisqualic Acid; Receptors, N-Methyl-D-Aspartate; Seizures | 1990 |
Synthesis and anticonvulsant activity of some new 2-substituted 3-aryl-4(3H)-quinazolinones.
Topics: Animals; Anticonvulsants; Bicuculline; Chemical Phenomena; Chemistry; Drug Evaluation, Preclinical; Electroshock; Lethal Dose 50; Male; Methaqualone; Mice; Molecular Structure; Pentylenetetrazole; Picrotoxin; Pyridines; Rats; Rats, Inbred Strains; Seizures; Structure-Activity Relationship; Strychnine | 1990 |
Effect of straight chain fatty acids on seizures induced by picrotoxin and pentylenetetrazole in mice.
Topics: Animals; Anticonvulsants; Decanoic Acids; Fatty Acids; Lauric Acids; Male; Mice; Myristic Acid; Myristic Acids; Palmitic Acid; Palmitic Acids; Pentylenetetrazole; Picrotoxin; Seizures; Stearic Acids | 1990 |
Differential effects of gamma-hexachlorocyclohexane (lindane) on pharmacologically-induced seizures.
Topics: Animals; Binding, Competitive; Brain; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Drug Synergism; Hexachlorocyclohexane; Male; Mice; Pentylenetetrazole; Picrotoxin; Seizures | 1987 |
CNS biochemical and pharmacological effects of the isomers of hexachlorocyclohexane (lindane) in the mouse.
Topics: Animals; Brain; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Chlorides; Drug Synergism; Hexachlorocyclohexane; Ion Channels; Male; Mice; Motor Activity; Pentylenetetrazole; Picrotoxin; Receptors, GABA-A; Seizures | 1988 |
Convulsant-induced changes in perforant path-dentate gyrus excitability in urethane anesthetized rats.
Topics: Animals; Bicuculline; Convulsants; Dose-Response Relationship, Drug; Hexachlorocyclohexane; Hippocampus; Kainic Acid; Male; Pentylenetetrazole; Picrotoxin; Rats; Rats, Inbred Strains; Urethane | 1988 |
Effects of the acute and chronic administration of chlordiazepoxide on the development of spontaneous motility in chick embryos.
Topics: Animals; Bicuculline; Chick Embryo; Chlordiazepoxide; gamma-Aminobutyric Acid; Movement; Pentylenetetrazole; Picrotoxin; Strychnine; Time Factors | 1989 |
[Effector modelling of the action of ligands of the GABA-receptor complex, cooperativity of the processes and the type of modification of the complex by convulsants and their reversible agonists].
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Barbital; Bemegride; Benzodiazepines; Benzodiazepinones; Bicuculline; Convulsants; Drug Interactions; Female; Ligands; Mathematics; Mice; Mice, Inbred CBA; Models, Biological; Pentylenetetrazole; Picrotoxin; Receptors, GABA-A | 1989 |
[Effector modeling of the action of ligands of GABA-receptor complex. Functional interaction of the hypothetic alcohol receptor with other subunits of the complex].
Topics: 1-Propanol; Alcohols; Animals; Barbiturates; Bemegride; Bicuculline; Butanols; Ethanol; Female; Methanol; Mice; Mice, Inbred CBA; Models, Biological; Pentanols; Pentylenetetrazole; Picrotoxin; Receptors, GABA-A; Semicarbazides | 1989 |
Glutamate receptor agonists increase the expression of Fos, Fra, and AP-1 DNA binding activity in the mammalian brain.
Topics: Animals; Anticonvulsants; Aspartic Acid; Binding, Competitive; Blotting, Northern; Convulsants; DNA-Binding Proteins; Electroshock; Gene Expression Regulation; Immunoblotting; Kainic Acid; Male; Mice; Mice, Inbred BALB C; N-Methylaspartate; Nucleic Acid Hybridization; Pentylenetetrazole; Picrotoxin; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-fos; Proto-Oncogene Proteins c-jun; Receptors, Glutamate; Receptors, Neurotransmitter; RNA, Messenger; Seizures; Transcription Factors | 1989 |
Enhancement of benzodiazepine receptor binding by L-lysine is chloride-dependent and due to increase in binding affinity.
Topics: Animals; Cattle; Chlorides; Flunitrazepam; In Vitro Techniques; Kinetics; Lysine; Pentylenetetrazole; Picrotoxin; Receptors, GABA-A; Sesterterpenes; Synaptic Membranes | 1989 |
Pentylenetetrazol kindling in mice.
Topics: Animals; Anticonvulsants; Aspartic Acid; Brain; Cannabidiol; Electric Stimulation; Kindling, Neurologic; Male; Mice; N-Methylaspartate; Neurotransmitter Agents; Pentylenetetrazole; Picrotoxin | 1989 |
[Effect of brain extracts from rats subjected to korazol kindling on generalized epileptic activity].
Topics: Animals; Brain; Drug Interactions; Epilepsy; Kindling, Neurologic; Male; Mice; Mice, Inbred C57BL; Mice, Inbred CBA; Naloxone; Pentylenetetrazole; Peptides; Picrotoxin; Rats; Rats, Inbred Strains | 1989 |
Inhibitory effect of intravenous GABA antagonists on gastric acid secretion stimulated by secretagogues in rats.
Topics: Animals; Bethanechol Compounds; Bicuculline; Deoxyglucose; GABA Antagonists; Gastric Acid; Injections, Intravenous; Male; Paralysis; Pentylenetetrazole; Picrotoxin; Rats; Rats, Inbred Strains; Spinal Cord Injuries; Stomach; Strychnine; Tubocurarine | 1989 |
The pentylenetetrazol-like interoceptive stimulus produced by ethanol withdrawal is potentiated by bicuculline and picrotoxinin.
Topics: Animals; Anxiety; Bicuculline; Discrimination Learning; Dose-Response Relationship, Drug; Ethanol; GABA Antagonists; Male; Pentylenetetrazole; Picrotoxin; Rats; Seizures; Sesterterpenes; Substance Withdrawal Syndrome | 1989 |
Effects of the diterpene sclareol glycol on convulsive seizures.
Topics: Animals; Bicuculline; Colforsin; Convulsants; Diterpenes; Drug Synergism; Male; Mice; Pentylenetetrazole; Picrotoxin; Seizures | 1989 |
Effects of muscimol, cetyl-GABA, pentetrazol and picrotoxin on timidity during intraspecies conflict in mice.
Topics: Aggression; Animals; GABA Antagonists; gamma-Aminobutyric Acid; Male; Mice; Muscimol; Pentylenetetrazole; Picrotoxin; Species Specificity | 1989 |
[Effector modeling of the action of GABA-receptor complex ligands. Functional interactions of subunits of the complex].
Topics: Animals; Barbital; Benzodiazepines; Bicuculline; Dose-Response Relationship, Drug; Ligands; Male; Mice; Mice, Inbred CBA; Models, Biological; Pentylenetetrazole; Picrotoxin; Receptors, GABA-A | 1988 |
Exacerbation of indomethacin-induced gastric ulceration by systemically administered GABA in rats: possible involvement of peripheral GABA receptors.
Topics: Animals; Anticonvulsants; Atropine; beta-Alanine; Bicuculline; Drug Synergism; gamma-Aminobutyric Acid; Glycine; Indomethacin; Male; Muscimol; Pentobarbital; Pentylenetetrazole; Picrotoxin; Rats; Rats, Inbred Strains; Receptors, GABA-A; Stomach Ulcer; Taurine | 1988 |
[Effector modeling of the effect of ligands of GABA receptor complex. Modification of conformation states of the complex by combined administration of benzodiazepines and barbiturates].
Topics: Animals; Anti-Anxiety Agents; Barbital; Barbiturates; Benzodiazepines; Benzodiazepinones; Bicuculline; Diazepam; Drug Antagonism; Female; Ligands; Mice; Models, Biological; Pentylenetetrazole; Picrotoxin; Receptors, GABA-A | 1988 |
[Proconvulsant effect of morphine on seizures induced by pentylenetetrazol in the mice].
Topics: Animals; Bicuculline; Convulsants; Drug Synergism; Male; Mice; Morphine; Pentylenetetrazole; Picrotoxin; Receptors, GABA-A | 1988 |
Effects of acute and chronic treatment on the pro- and anti-convulsant actions of CL 218, 872, PK 8165 and PK 9084, putative ligands for the benzodiazepine receptor.
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Male; Mice; Pentylenetetrazole; Picrotoxin; Pyridazines; Quinolines; Receptors, GABA-A; Time Factors | 1985 |
Does the benzodiazepine antagonist Ro 15-1788 reverse the actions of picrotoxin and pentylenetetrazole on social and exploratory behaviour?
Topics: Animals; Anti-Anxiety Agents; Benzodiazepinones; Exploratory Behavior; Flumazenil; Male; Motor Activity; Pentylenetetrazole; Picrotoxin; Rats; Social Behavior | 1985 |
Effects of Suanzaorentang on behavior changes and central monoamines.
Topics: Animals; Anti-Anxiety Agents; Biogenic Amines; Brain; Drugs, Chinese Herbal; Kinetics; Male; Motor Activity; Pentylenetetrazole; Picrotoxin; Plant Extracts; Rats; Rats, Inbred Strains; Sleep; Strychnine | 1986 |
The role of GABA and excitatory amino acids in the development of the leptazol-induced epileptogenic EEG.
Topics: Allylglycine; Amino Acids; Animals; Bicuculline; Cerebral Cortex; Clonazepam; Dose-Response Relationship, Drug; Electroencephalography; GABA Antagonists; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Male; Pentylenetetrazole; Picrotoxin; Rats; Rats, Inbred Strains; Seizures; Time Factors; Valproic Acid | 1986 |
Effect of inferior olive lesion on seizure threshold in the rat.
Topics: Animals; Bicuculline; Cerebellum; Convulsants; Male; Motor Activity; Neural Pathways; Olivary Nucleus; Pentylenetetrazole; Picrotoxin; Rats; Rats, Inbred Strains; Reaction Time; Seizures; Strychnine | 1987 |
Ro 15-1788, CGS 8216, picrotoxin, and pentylenetetrazol: do they antagonize anxiolytic drug effects through an anxiogenic action?
Topics: Animals; Anti-Anxiety Agents; Behavior, Animal; Drug Interactions; Flumazenil; Humans; Injections, Intraperitoneal; Male; Pentylenetetrazole; Picrotoxin; Pyrazoles; Rats; Receptors, GABA-A | 1987 |
CGS 19755, a selective and competitive N-methyl-D-aspartate-type excitatory amino acid receptor antagonist.
Topics: Acetylcholine; Aconitine; Animals; Anticonvulsants; Aspartic Acid; Avoidance Learning; Binding, Competitive; Darkness; Glutamates; Glutamic Acid; Male; N-Methylaspartate; Pentylenetetrazole; Picrotoxin; Pipecolic Acids; Piperidines; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Seizures; Structure-Activity Relationship; Tetrodotoxin | 1988 |
Evidence for involvement of the astrocytic benzodiazepine receptor in the mechanism of action of convulsant and anticonvulsant drugs.
Topics: Animals; Anticonvulsants; Astrocytes; Barbiturates; Benzodiazepinones; Brain; Carbamazepine; Cells, Cultured; Convulsants; Diazepam; Ethosuximide; Mice; Neurons; Pentylenetetrazole; Phenobarbital; Picrotoxin; Receptors, GABA-A; Sesterterpenes; Trimethadione; Valproic Acid | 1988 |
Involvement of bicuculline-insensitive receptors in the hypothermic effect of GABA and its agonists.
Topics: Amino Acids; Amino Acids, Neutral; Animals; Bicuculline; Body Temperature; Drug Interactions; Female; gamma-Aminobutyric Acid; Hypothermia; Pentylenetetrazole; Picrotoxin; Rats; Rats, Inbred Strains; Receptors, GABA-A; Time Factors; Valproic Acid | 1985 |
Convulsant component of a depressant benzodiazepine.
Topics: Animals; Benzodiazepinones; Diazepam; Dose-Response Relationship, Drug; Flumazenil; Male; Pentylenetetrazole; Picrotoxin; Rats; Rats, Inbred Strains; Receptors, GABA-A; Seizures | 1985 |
Proconflict effect of GABA receptor complex antagonists. Reversal by diazepam.
Topics: Animals; Benzodiazepinones; Bicuculline; Conflict, Psychological; Diazepam; Flumazenil; Male; Pentylenetetrazole; Picrotoxin; Rats; Rats, Inbred Strains; Receptors, GABA-A | 1986 |
The effects of drugs acting at the GABAA-receptor/ionophore after chemical kindling with the benzodiazepine receptor ligand FG 7142.
Topics: Animals; Bicuculline; Body Temperature; Carbolines; gamma-Aminobutyric Acid; Kindling, Neurologic; Male; Mice; Muscimol; Pentobarbital; Pentylenetetrazole; Picrotoxin; Receptors, GABA-A; Seizures; Time Factors | 1986 |
2-Amino-6-trifluoromethoxy benzothiazole, a possible antagonist of excitatory amino acid neurotransmission--I. Anticonvulsant properties.
Topics: Amino Acids; Animals; Anticonvulsants; Bicuculline; Electroshock; Female; Glutamate Decarboxylase; Harmaline; Male; Mice; Mice, Inbred DBA; Ouabain; Papio; Pentylenetetrazole; Picrotoxin; Rats; Riluzole; Seizures; Synaptic Transmission; Thiazoles | 1985 |
Evidence for increased activity of mouse brain fatty acid cyclooxygenase following drug-induced convulsions.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Brain; Dinoprost; Dinoprostone; Ethosuximide; Female; Kinetics; Mice; Microsomes; Pentylenetetrazole; Picrotoxin; Prostaglandin-Endoperoxide Synthases; Prostaglandins E; Prostaglandins F; Seizures; Strychnine | 1987 |
Microgram doses of diazepam do not induce proconvulsant or proconflict effects in rodents.
Topics: Animals; Bicuculline; Conditioning, Operant; Diazepam; Isoniazid; Mice; Pentylenetetrazole; Picrotoxin; Punishment; Seizures | 1987 |
Changes in GABA content of the brain and sensitivity to GABA-antagonists during and after repetitive treatment of rats with diphenilhydantoin.
Topics: Animals; Brain; Electroshock; GABA Antagonists; gamma-Aminobutyric Acid; Male; Pentylenetetrazole; Phenytoin; Picrotoxin; Rats; Rats, Inbred Strains; Seizures | 1988 |
Convulsant-induced increase in transcription factor messenger RNAs in rat brain.
Topics: Animals; Autoradiography; Blotting, Northern; Brain; Convulsants; Gene Expression Regulation; Male; Neurons; Nucleic Acid Hybridization; Pentylenetetrazole; Picrotoxin; Rats; Rats, Inbred Strains; RNA, Messenger; Transcription Factors | 1988 |
Pentobarbital augments serotonin-mediated inhibition of cerebellar Purkinje cells.
Topics: Action Potentials; Animals; gamma-Aminobutyric Acid; Male; Neural Inhibition; Pentobarbital; Pentylenetetrazole; Picrotoxin; Purkinje Cells; Rats; Rats, Inbred Strains; Serotonin | 1988 |
Differences in GABA activity between ethanol withdrawal seizure prone and resistant mice.
Topics: Animals; Bicuculline; Brain; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Convulsants; Ethanol; Female; Flunitrazepam; gamma-Aminobutyric Acid; Male; Mice; Mice, Inbred Strains; Pentylenetetrazole; Picrotoxin; Seizures; Substance Withdrawal Syndrome | 1988 |
Interactions of the imidazodiazepine Ro 15-4513 with chemical convulsants.
Topics: Animals; Azides; Benzodiazepines; Benzodiazepinones; Bicuculline; Carbolines; Convulsants; Drug Interactions; Male; Mice; Pentylenetetrazole; Picrotoxin; Seizures | 1988 |
Possible involvement of the central GABAergic system in pentobarbital-stimulated gastric acid secretion in the perfused rat stomach preparation.
Topics: 3-Mercaptopropionic Acid; Anesthesia; Animals; Bicuculline; Diazepam; gamma-Aminobutyric Acid; Gastric Acid; Gastric Mucosa; In Vitro Techniques; Male; Pentobarbital; Pentylenetetrazole; Perfusion; Picrotoxin; Rats; Rats, Inbred Strains; Urethane | 1988 |
Gamma-vinyl GABA: comparison of neurochemical and anticonvulsant effects in mice.
Topics: 4-Aminobutyrate Transaminase; Amino Acids; Aminocaproates; Animals; Anticonvulsants; Brain; gamma-Aminobutyric Acid; Injections; Isoniazid; Mice; Osmolar Concentration; Pentylenetetrazole; Picrotoxin; Seizures; Vigabatrin | 1988 |
Differential effects of caffeine, picrotoxin, and pentylenetetrazol on hippocampal afterdischarge activity and wet dog shakes.
Topics: Animals; Caffeine; Electroencephalography; Hippocampus; Male; Membrane Potentials; Pentylenetetrazole; Picrotoxin; Rats; Seizures | 1987 |
GABAergic drugs can enhance or attenuate chlordiazepoxide-induced sleep time in a heterogeneous strain of mice.
Topics: Acetates; Aminooxyacetic Acid; Animals; Bicuculline; Chlordiazepoxide; GABA Antagonists; gamma-Aminobutyric Acid; Mice; Pentylenetetrazole; Picrotoxin; Sleep | 1986 |
Effect of stimulus intensity on the profile of anticonvulsant activity of phenytoin, ethosuximide and valproate.
Topics: Animals; Anticonvulsants; Bicuculline; Electroshock; Ethosuximide; Male; Mice; Pentylenetetrazole; Phenytoin; Picrotoxin; Seizures; Valproic Acid | 1985 |
Spiro[4.5] and spiro[4.6] carboxylic acids: cyclic analogues of valproic acid. Synthesis and anticonvulsant evaluation.
Topics: Animals; Anticonvulsants; Bicuculline; Carboxylic Acids; Male; Mice; Pentylenetetrazole; Picrotoxin; Spiro Compounds; Structure-Activity Relationship; Valproic Acid | 1985 |
An EEG investigation on the role of cerebello-rubral system in the effects of diazepam and pentobarbital.
Topics: Animals; Benzodiazepinones; Cerebellum; Diazepam; Electroencephalography; Female; Flumazenil; Male; Pentobarbital; Pentylenetetrazole; Picrotoxin; Rabbits; Red Nucleus | 1985 |
An analysis of the in vivo interactions between chemical convulsants and anticonvulsants.
Topics: Animals; Anticonvulsants; Bicuculline; Convulsants; Diazepam; Dose-Response Relationship, Drug; Drug Interactions; Mice; Pentylenetetrazole; Phenobarbital; Picrotoxin; Valproic Acid | 1985 |
Changes in local cerebral glucose utilization induced by convulsants.
Topics: Animals; Bicuculline; Brain; Convulsants; Glucose; Male; Penicillins; Pentylenetetrazole; Picrotoxin; Rats; Rats, Inbred Strains; Soman; Strychnine | 1985 |
Antagonism of picrotoxin against the taming effect of carbamazepine on footshock induced fighting behavior in mice.
Topics: Aggression; Animals; Bicuculline; Carbamazepine; Diazepam; Electroshock; gamma-Aminobutyric Acid; Haloperidol; Lithium; Male; Mice; Pentylenetetrazole; Picrotoxin | 1985 |
Effect of lyoniol-A on decerebrate rigidity and electroencephalogram in rats.
Topics: Amygdala; Animals; Brain; Caudate Nucleus; Cerebral Decortication; Chlorpromazine; Diterpenes; Electroencephalography; Electromyography; Ethers, Cyclic; Hippocampus; Hypothalamus; Limbic System; Male; Mephenesin; Motor Cortex; Pentobarbital; Pentylenetetrazole; Picrotoxin; Polycyclic Compounds; Rats; Strychnine; Toxins, Biological | 1972 |
Effects of convulsants on cortical adenosine triphosphatases.
Topics: Adenosine Triphosphatases; Alkaloids; Amines; Animals; Central Nervous System Stimulants; Cerebral Cortex; Dogs; Drug Combinations; Enzyme Activation; Ethacrynic Acid; Fluoroacetates; In Vitro Techniques; Indoles; Mercury; Mescaline; Methionine Sulfoximine; Organometallic Compounds; Pentylenetetrazole; Picrotoxin; Succinates; Succinylcholine; Theophylline; Thiourea; Tubocurarine | 1973 |
On the importance of a central beta-adrenoceptor site in the antiarrhythmic activity of beta-blockers.
Topics: Aconitum; Adrenal Glands; Adrenergic beta-Antagonists; Alprenolol; Animals; Arrhythmias, Cardiac; Catecholamines; Coronary Vessels; Dogs; Hypothalamus; Pentylenetetrazole; Picrotoxin; Pindolol; Propranolol; Receptors, Drug | 1972 |
A comparative study of some convulsant substances as gamma-aminobutyric acid antagonists in the feline cerebral cortex.
Topics: Action Potentials; Alkaloids; Aminobutyrates; Animals; Cats; Central Nervous System Stimulants; Cerebral Cortex; Dioxoles; Dose-Response Relationship, Drug; Drug Synergism; Female; Hydrogen-Ion Concentration; Isoquinolines; Male; Neurons; Penicillin G; Pentylenetetrazole; Picrotoxin; Strychnine; Tubocurarine | 1973 |
The influence of serotonin, GABA and DL-dopa on the circadian rhythm in the toxicity of picrotoxin, pentylenetetrazol and phenobarbital in mice.
Topics: Aminobutyrates; Animals; Circadian Rhythm; Dihydroxyphenylalanine; gamma-Aminobutyric Acid; Lethal Dose 50; Male; Mice; Pentylenetetrazole; Phenobarbital; Picrotoxin; Serotonin; Time Factors | 1974 |
Convulsant drugs: amino acid antagonism and central inhibition.
Topics: Action Potentials; Alkaloids; Amino Acids; Animals; Anura; Binding Sites; Central Nervous System Stimulants; Cerebral Cortex; Crustacea; Dioxoles; Evoked Potentials; GABA Antagonists; Glycine; Iontophoresis; Isoquinolines; Mammals; Membranes; Neural Inhibition; Neuromuscular Junction; Neurons; Neurotransmitter Agents; Pentylenetetrazole; Picrotoxin; Rats; Receptors, Drug; Species Specificity; Strychnine; Synaptic Transmission; Tritium | 1974 |
Acetylcholine levels in the frog spinal cord following the administration of different convulsants.
Topics: Acetylcholine; Alkaloids; Animals; Brain Chemistry; Central Nervous System Stimulants; Dioxoles; In Vitro Techniques; Isoquinolines; Methyl Ethers; Myocardium; Pentylenetetrazole; Picrotoxin; Rana esculenta; Seasons; Spinal Cord; Strychnine; Thebaine; Time Factors | 1974 |
The action of convulsants on neuronal and gross wave activity in the thalamus and in the cortex.
Topics: Animals; Cats; Cerebral Cortex; Injections, Intravenous; Neurons; Pentylenetetrazole; Picrotoxin; Seizures; Thalamus | 1963 |
Te function of the caudate nucleus in the control of some paroxystic activities in the neuraxis.
Topics: Animals; Cats; Caudate Nucleus; Central Nervous System; Cerebral Cortex; Electric Stimulation; Electrophysiology; Oxazines; Pentylenetetrazole; Picrotoxin; Pyrazines; Spinal Cord; Strychnine | 1969 |
The effects of some drugs on an evoked response sensitive to tetrahydrocannabinols.
Topics: Animals; Atropine; Blood Pressure; Brain; Cannabis; Cerebral Cortex; Chloralose; Chlorpromazine; Decerebrate State; Dextroamphetamine; Dronabinol; Electroencephalography; Ethanol; Evoked Potentials; Gallamine Triethiodide; Haplorhini; Lysergic Acid Diethylamide; Male; Mescaline; Methoxamine; Norepinephrine; Pentobarbital; Pentylenetetrazole; Phencyclidine; Picrotoxin; Strychnine | 1974 |
[Relations between sympathetic activation and blood pressure effect following injection of central analeptics].
Topics: Action Potentials; Aminobutyrates; Animals; Bemegride; Blood Pressure; Cats; Nikethamide; Pentylenetetrazole; Picrotoxin; Stimulation, Chemical; Sympathetic Nervous System | 1970 |
The developing animal as a model.
Topics: Age Factors; Animals; Barbiturates; Brain; Central Nervous System; Electric Stimulation; Electroshock; Fetus; Pentylenetetrazole; Phenytoin; Picrotoxin; Rats; Reflex; Seizures; Spinal Cord; Strychnine; Synaptic Transmission; Time Factors | 1969 |
The pharmacological properties of 2,2-bis-(3',4'-dimethoxyphenyl)-N-methyl-N-propargyl ethylamine (BAEA).
Topics: Animals; Blood Pressure; Cats; Electroencephalography; Ganglionic Blockers; Heart; Hypnotics and Sedatives; Mice; Neuromuscular Junction; Pentobarbital; Pentylenetetrazole; Picrotoxin; Strychnine | 1965 |
Hypnotic-analeptic interaction at different neural levels in cats and rabbits.
Topics: Animals; Bemegride; Cats; Central Nervous System; Central Nervous System Stimulants; Decerebrate State; Pentobarbital; Pentylenetetrazole; Picrotoxin; Rabbits | 1965 |
Pulmonary changes with convulsions induced by drugs and oxygen at high pressure.
Topics: Amino Alcohols; Animals; Central Nervous System Stimulants; Chlorpromazine; Curare; Dibenzylchlorethamine; Hyperbaric Oxygenation; Lung; Oxygen; Pentobarbital; Pentylenetetrazole; Picrotoxin; Pulmonary Edema; Rats; Seizures; Sympatholytics | 1966 |
Shortening of coma duration in narcotic poisoning.
Topics: Central Nervous System Stimulants; Coma; Diuresis; Hexobarbital; Humans; Narcotics; Nikethamide; Pentylenetetrazole; Picrotoxin; Renal Dialysis | 1966 |
The effect of convulsant drugs on coaxially stimulated guinea-pig ileum.
Topics: Animals; Atropine; Bemegride; Central Nervous System Stimulants; Electric Stimulation; Guinea Pigs; Hexamethonium Compounds; Ileum; In Vitro Techniques; Nikethamide; Norepinephrine; Pentylenetetrazole; Picrotoxin; Strychnine | 1967 |
The effect of selected drugs on the "emotional" behavior elicited via hypothalamic stimulation.
Topics: Amphetamine; Animals; Atropine; Behavior, Animal; Cats; Chlorpromazine; Depression, Chemical; Electric Stimulation; Emotions; Hypothalamus; Imipramine; Meprobamate; Pentylenetetrazole; Phenobarbital; Phenytoin; Picrotoxin; Pregnanediones; Reserpine; Scopolamine; Stimulation, Chemical; Strychnine; Tremorine | 1968 |
Pharmacological properties of the postsynaptic inhibition by Purkinje cell axons and the action of gamma-aminobutyric acid on deiters NEURONES.
Topics: Action Potentials; Aminobutyrates; Animals; Axons; Bemegride; Cats; Dibenzylchlorethamine; Dopamine; Electrophysiology; Ethanolamines; Evoked Potentials; Hydroxylamines; Membrane Potentials; Norepinephrine; Pentylenetetrazole; Picrotoxin; Purkinje Cells; Sensory Receptor Cells; Strychnine; Synapses; Transaminases; Vestibular Nuclei | 1967 |
The efficacy of managing postanaesthetic respiratory depression with analeptics.
Topics: Abdomen; Adult; Aged; Aminobutyrates; Anesthesia, General; Animals; Arousal; Bemegride; Benzamides; Carbon Dioxide; Central Nervous System Stimulants; Dextroamphetamine; Dogs; Doxapram; Humans; Hydrogen-Ion Concentration; Hypoxia; Methoxyflurane; Methylphenidate; Middle Aged; Nikethamide; Nitrous Oxide; Oxygen; Pentylenetetrazole; Picrotoxin; Thiopental | 1966 |
Use of chronic irritative foci in laboratory evaluation of antiepileptic drugs.
Topics: Aluminum; Aminobutyrates; Animals; Bemegride; Central Nervous System Stimulants; Chlordiazepoxide; Chlorpromazine; Diazepam; Diphenhydramine; Electroencephalography; Ethers; Fluorine; Haplorhini; Hydroxides; Hydroxylamines; Isoflurophate; Pentylenetetrazole; Picrotoxin; Pyridoxine; Reserpine; Seizures; Semicarbazides; Strychnine | 1969 |
The bronchodilator action of analeptics in the guinea-pig.
Topics: Adrenalectomy; Animals; Bemegride; Bronchi; Catecholamines; Central Nervous System Stimulants; Dilatation; Guinea Pigs; Methacholine Compounds; Nikethamide; Pentylenetetrazole; Picrotoxin; Propranolol | 1969 |
Effect of analeptics on brain pentobarbital levels and sleeping time in mice.
Topics: Animals; Brain Chemistry; Central Nervous System Stimulants; Female; Mice; Nikethamide; Pentobarbital; Pentylenetetrazole; Picrotoxin; Sleep; Time Factors | 1969 |
Action of central nervous system stimulant and depressant drugs in the intact animal. 4. Surface activity of drugs with central stimulant depressant, or dual stimulant-depressant action.
Topics: Air; Amobarbital; Barbiturates; Central Nervous System Stimulants; Chemical Phenomena; Chemistry; Depression, Chemical; Glutarates; Hypnotics and Sedatives; Oxazines; Pentobarbital; Pentylenetetrazole; Phenytoin; Picrotoxin; Pregnanediones; Solutions; Stimulation, Chemical; Surface Properties; Surface Tension; Trimethadione | 1969 |
Influence of alkylamides of glutamic acid and related compounds on the central nervous system. I. Central depressant effect of theanine.
Topics: Amides; Amino Acids; Animals; Bemegride; Brain; Brain Chemistry; Caffeine; Carbon Isotopes; Central Nervous System; Depression, Chemical; Glutamine; Hexobarbital; Liver; Male; Mice; Pentylenetetrazole; Picrotoxin; Piperidines; Seizures; Sleep; Strychnine | 1971 |
The effect of bicuculline, metrazol, picrotoxin and strychnine on the release of ( 3 H)GABA from rat brain slices.
Topics: Alkaloids; Aminobutyrates; Animals; Central Nervous System Stimulants; Cerebral Cortex; Dioxoles; Electric Stimulation; Evoked Potentials; Isoquinolines; Neural Inhibition; Pentylenetetrazole; Perfusion; Picrotoxin; Rats; Strychnine; Synaptic Transmission; Tritium | 1971 |
Effects of gamma-hydroxybutyrate on chick behaviour, electrocortical activity and crossed extensor reflexes.
Topics: Action Potentials; Animals; Anticonvulsants; Behavior, Animal; Central Nervous System Stimulants; Cerebral Cortex; Chickens; Drug Synergism; Electroencephalography; Electromyography; Electrophysiology; Hydroxybutyrates; Myoclonus; Pentylenetetrazole; Picrotoxin; Reflex; Strychnine | 1972 |
Convulsive activity in garter snakes.
Topics: Animals; Behavior, Animal; Bemegride; Body Temperature; Brain; Central Nervous System; Central Nervous System Stimulants; Electroencephalography; Evoked Potentials; Pentylenetetrazole; Picrotoxin; Receptors, Adrenergic; Receptors, Cholinergic; Seizures; Snakes; Strychnine; Synapses | 1972 |
Effect on pseudoconditioning of drugs with known central nervous activity.
Topics: Amobarbital; Animals; Avoidance Learning; Behavior, Animal; Caffeine; Cannabis; Chlorpromazine; Conditioning, Psychological; Depression, Chemical; Diazepam; Dibenzylchlorethamine; Female; Meprobamate; Pentylenetetrazole; Phenobarbital; Phenytoin; Picrotoxin; Rats; Stimulation, Chemical; Strychnine; Trimethadione | 1974 |
[Effects of picrotoxin and pentetrazol on experimental sleep in the mouse].
Topics: Animals; Brain Chemistry; Chloral Hydrate; Chlormethiazole; Hexobarbital; Pentobarbital; Pentylenetetrazole; Picrotoxin; Sleep; Time Factors | 1974 |
Inhibition of post-decapitation convulsions by reserpine.
Topics: Animals; Cervical Vertebrae; Cordotomy; Male; Norepinephrine; Pentylenetetrazole; Picrotoxin; Rats; Reserpine; Seizures; Strychnine | 1973 |
Changes in sensitivity to convulsion in mice with olfactory bulb ablation.
Topics: Animals; Cyclohexanes; Electroshock; Limbic System; Male; Mice; Olfactory Bulb; Pentylenetetrazole; Picrotoxin; Seizures; Strychnine | 1972 |
[Effects of various pharmacological agents on neocortical seizure activities in the rabbit].
Topics: Aminobutyrates; Animals; Cerebral Cortex; Cocaine; Electric Stimulation; Electroencephalography; Evoked Potentials; Lidocaine; Pentylenetetrazole; Phenobarbital; Phenytoin; Picrotoxin; Rabbits; Strychnine | 1972 |
Effect of lithium on acute oxygen toxicity and associated changes in brain gamma-aminobutyric acid.
Topics: Aminobutyrates; Animals; Brain; Brain Chemistry; Hyperbaric Oxygenation; Lithium; Magnesium; Male; Manganese; Oxygen; Pentylenetetrazole; Picrotoxin; Pulmonary Edema; Rats; Seizures; Strychnine; Thiosemicarbazones; Zinc | 1973 |
Differential effects of convulsive drugs on photically evoked after-discharge parameters.
Topics: Animals; Cerebral Cortex; Electrodes, Implanted; Electrophysiology; Habituation, Psychophysiologic; Occipital Lobe; Pentylenetetrazole; Photic Stimulation; Picrotoxin; Rats; Strychnine; Visual Cortex | 1973 |
Some studies on the convulsant action of folic acid.
Topics: Alkaloids; Animals; Auditory Threshold; Cerebral Ventricles; Dioxoles; Electroshock; Folic Acid; Folic Acid Antagonists; Glutamates; Injections; Injections, Intravenous; Isoquinolines; Mice; Ouabain; Pentylenetetrazole; Phenobarbital; Phenytoin; Picrotoxin; Seizures; Strychnine | 1973 |
Convulsions elicited by handling: a sensitive method of measuring CNS excitation in mice treated with reserpine or convulsant drugs.
Topics: Animals; Central Nervous System; Dose-Response Relationship, Drug; Ethanol; Humans; Male; Mice; Pentylenetetrazole; Picrotoxin; Reserpine; Seizures; Strychnine; Substance Withdrawal Syndrome; Time Factors | 1973 |
[Action of cardiazol on electrical activity of the spinal cord (spontaneous and evoked potentials)-cardiazol as an antagonist of pentobarbital].
Topics: Action Potentials; Animals; Bemegride; Cats; Evoked Potentials; Female; Male; Pentobarbital; Pentylenetetrazole; Picrotoxin; Spinal Cord; Spinal Nerve Roots | 1973 |
Pharmacology of cortical inhibition.
Topics: Alkaloids; Amino Acids; Aminobutyrates; Amphetamine; Anesthetics; Animals; Atropine; Cats; Cortical Spreading Depression; Haplorhini; Iontophoresis; Morphine; Parasympathomimetics; Pentylenetetrazole; Picrotoxin; Rabbits; Strychnine; Tetanus Toxin; Thiosemicarbazones; Tubocurarine | 1966 |
Slow rhythms of sympathetic discharge induced by convulsant drugs.
Topics: Action Potentials; Animals; Autonomic Fibers, Preganglionic; Blood Pressure; Cats; Evoked Potentials; Motor Neurons; Neuroeffector Junction; Neurons, Efferent; Nictitating Membrane; Pentylenetetrazole; Phrenic Nerve; Picrotoxin; Sciatic Nerve; Strychnine | 1972 |
Blockade of central GABA receptors and the convulsive actions of bicuculline, picrotoxin and leptazol.
Topics: Action Potentials; Alkaloids; Aminobutyrates; Animals; Cats; Dioxoles; Iontophoresis; Isoquinolines; Pentylenetetrazole; Picrotoxin; Receptors, Drug | 1972 |
Neuropharmacological studies of imidazole-4-acetic acid actions in the mouse and rat.
Topics: Acetates; Animals; Ataxia; Behavior; Caffeine; Catalepsy; Central Nervous System; Drug Interactions; Drug Synergism; Electroencephalography; Humans; Hydroxybutyrates; Imidazoles; Injections, Intraperitoneal; Male; Mice; Mice, Inbred Strains; Motor Activity; Pentylenetetrazole; Phenobarbital; Picrotoxin; Rats; Rats, Inbred Strains; Sleep; Stimulation, Chemical; Strychnine; Time Factors | 1971 |
The central action of gamma-butyrolactone and gamma-hydroxybutyrate.
Topics: Analysis of Variance; Animals; Behavior, Animal; Butyrates; Central Nervous System; Electric Stimulation; Electroencephalography; Electroshock; Female; Hippocampus; Hydroxybutyrates; Injections, Intraperitoneal; Injections, Intravenous; Lactones; Male; Mice; Pentobarbital; Pentylenetetrazole; Picrotoxin; Rabbits; Rats; Respiration; Reticular Formation; Semicarbazides; Sleep; Strychnine | 1967 |
Effects of N, N' -diphenyldicarbamate-1,1-demethylol cyclopentane (Carmalon) on the spinal cord reflexes.
Topics: Animals; Atropine; Barbiturates; Cyclopentanes; Depression, Chemical; Electric Stimulation; Male; Mephenesin; Mice; Pentylenetetrazole; Picrotoxin; Reflex; Seizures; Sleep; Spinal Cord; Strychnine | 1968 |
[Modification of cortical facilitation and depression processes by strychnine, picrotoxin and pentetrazol].
Topics: Action Potentials; Animals; Cerebral Cortex; Cortical Spreading Depression; Dental Pulp; Electric Stimulation; Electroencephalography; Pentylenetetrazole; Picrotoxin; Rabbits; Strychnine | 1969 |
Incorporation of carbon atoms from glucose into free amino acids in brain under normal and altered conditions.
Topics: Alanine; Amino Acids; Aminobutyrates; Animals; Aspartic Acid; Autoanalysis; Brain; Carbon Isotopes; Depression, Chemical; Glucose; Glutamates; Glutamine; Glycolates; Hypoxia; Injections, Intravenous; Lactates; Male; Metabolism; Methods; Pentobarbital; Pentylenetetrazole; Picrotoxin; Rats; Seizures; Stimulation, Chemical; Time Factors | 1970 |
Effects of various conditions on the movement of carbon atoms derived from glucose into and out of protein in rat brain.
Topics: Alanine; Amino Acids; Animals; Aspartic Acid; Autoanalysis; Brain; Carbon Isotopes; Cerebral Cortex; Depression, Chemical; Glucose; Glutamates; Hypoxia; Injections, Intravenous; Insulin; Male; Metabolism; Nerve Tissue Proteins; Pentobarbital; Pentylenetetrazole; Picrotoxin; Rats; Seizures; Stimulation, Chemical; Time Factors | 1970 |
Changes in click-evoked responses as a function of depth in auditory cortex of the rat.
Topics: Animals; Auditory Cortex; Computers; Ethers; Evoked Potentials; Halothane; Male; Noise; Pentylenetetrazole; Picrotoxin; Rats | 1970 |
Effect of metal ions on oxygen toxicity.
Topics: Animals; Atmospheric Pressure; Cobalt; Hydroxylamines; Hyperbaric Oxygenation; Injections, Intraperitoneal; Ions; Lung; Male; Manganese; Metals; Methods; Oxygen; Pentylenetetrazole; Picrotoxin; Potassium; Pulmonary Edema; Rats; Seizures; Strychnine; Thiosemicarbazones; Zinc | 1970 |
Microinjections of tubocurarine, leptazol, strychnine and picrotoxin into the cerebral cortex of anaesthetized cats.
Topics: Action Potentials; Anesthesia, General; Animals; Cats; Caudate Nucleus; Cerebral Cortex; Evoked Potentials; Female; Hypothalamus; Injections; Male; Neurons; Pentylenetetrazole; Picrotoxin; Strychnine; Thalamus; Tubocurarine | 1970 |
Concerning the depressant activity of analeptics (pentylenetetrazol, bemegride, nikethamide, picrotoxin).
Topics: Anesthesia; Animals; Barbiturates; Bemegride; Depression, Chemical; Guinea Pigs; Nikethamide; Nitrous Oxide; Pentylenetetrazole; Picrotoxin; Rats; Seizures | 1970 |
Spontaneous hemorrhage in anticoagulant-treated rats when subjected to excitant or depressant drugs.
Topics: Animals; Anticoagulants; Barbiturates; Blood Coagulation; Chlordiazepoxide; Chlorpromazine; Depression, Chemical; Drug Synergism; Hemorrhage; Male; Pentobarbital; Pentylenetetrazole; Picrotoxin; Rats; Stimulation, Chemical; Stress, Physiological | 1967 |
Effects of intracerebroventricular l-hyoscyamine, ethybenztropine and procaine on cardiac arrhythmias induced in dogs by pentylenetetrazol, picrotoxin or deslanoside.
Topics: Animals; Arrhythmias, Cardiac; Atropa belladonna; Bradycardia; Carotid Artery Thrombosis; Central Nervous System; Cerebral Ventricles; Depression, Chemical; Digitalis Glycosides; Dogs; Electric Stimulation; Epinephrine; Injections; Injections, Intravenous; Parasympatholytics; Pentylenetetrazole; Phytotherapy; Picrotoxin; Plants, Medicinal; Plants, Toxic; Procaine; Tropanes; Vagus Nerve; Vasomotor System | 1968 |
Effects of synthetic oxytocin on cardiac arrhythmias induced in dogs by pentylenetetrazol, picrotoxin or deslanoside.
Topics: Arrhythmias, Cardiac; Cardiovascular System; Electrocardiography; Heart Ventricles; Injections, Intramuscular; Injections, Intravenous; Lanatosides; Oxytocin; Pentylenetetrazole; Picrotoxin | 1968 |
The effect of intraperitoneal injections of hyperosmotic solutions on convulsions induced by drugs and hyperbaric oxygen.
Topics: Aminobutyrates; Animals; Brain Diseases; Dehydration; Glucose; Hyperbaric Oxygenation; Hypertonic Solutions; Injections, Intraperitoneal; Male; Osmolar Concentration; Pentylenetetrazole; Picrotoxin; Rats; Seizures; Semicarbazides; Urea | 1968 |
Effects of some centrally-acting drugs in conscious chicks and on spinal reflexes.
Topics: Animals; Carbamates; Chickens; Chlorpromazine; Male; Mephenesin; Meprobamate; Orphenadrine; Pentylenetetrazole; Picrotoxin; Reflex; Spinal Nerves; Strychnine; Triazines | 1968 |
Further studies on chemically induced siezures and their antagonism by anticonvulsants during postnatal development in the mouse.
Topics: Animals; Animals, Newborn; Anticonvulsants; Brain; Mice; Pentylenetetrazole; Phenobarbital; Picrotoxin; Seizures; Trimethadione | 1968 |
Electrophysiological investigations on homopantothenic acid.
Topics: Animals; Brain; Cats; Cerebral Cortex; Electroencephalography; Electrophysiology; Male; Pantothenic Acid; Pentylenetetrazole; Picrotoxin; Rabbits; Seizures; Time Factors | 1968 |
Hypnotic and hypothermic effect of pregnant mare urine extracts in the rat.
Topics: Amphetamine; Animals; Body Temperature; Female; Horses; Hypnosis; Hypothermia, Induced; Injections, Intraperitoneal; Iproniazid; Male; Pentylenetetrazole; Picrotoxin; Pregnancy; Pregnancy, Animal; Rats; Temperature; Urine | 1968 |
On the effect of cardiazol and picrotoxin on cats with crossed blood circulation.
Topics: Animals; Blood Transfusion; Cats; Electroencephalography; Pentylenetetrazole; Picrotoxin; Seizures | 1968 |
The effect of central stimulant drugs on acetylcholine release from rat cerebral cortex.
Topics: Acetylcholine; Anesthesia; Animals; Caffeine; Cerebral Cortex; Dextroamphetamine; Electroencephalography; Injections, Intraperitoneal; Male; Nikethamide; Pentylenetetrazole; Picrotoxin; Rats; Strychnine | 1968 |
[On the inflence of fluid volume on the efficacy of bemegride, Pentetrazole and picrotoxin in phenobarbital poisoning].
Topics: Animals; Bemegride; Mice; Pentylenetetrazole; Pharmaceutical Vehicles; Phenobarbital; Picrotoxin; Seizures; Sodium Chloride; Solutions; Suspensions | 1968 |
[The action of the caudate nucleus on the cerebrocortical paroxysmal bioelectrical activity induced by some drugs].
Topics: Animals; Cats; Caudate Nucleus; Cerebral Cortex; Electroencephalography; Pentylenetetrazole; Picrotoxin; Strychnine | 1968 |
Pharmacological significances of peptidase and proteinase in the brain. I. Enzymatic inactivation of bradykinin in rat brain.
Topics: Animals; Biological Assay; Bradykinin; Brain; Brain Stem; Carboxypeptidases; Cell Nucleus; Cerebellum; Cerebral Cortex; Depression, Chemical; Endopeptidases; Hydrogen-Ion Concentration; Male; Microsomes; Mitochondria; Muscle, Smooth; Nerve Tissue Proteins; Pentylenetetrazole; Peptide Hydrolases; Picrotoxin; Rats; Seizures; Stimulation, Chemical; Temperature | 1969 |
Pentylenetetrazol enhances memory function.
Topics: Animals; Behavior, Animal; Electroshock; Learning; Memory; Mice; Pentylenetetrazole; Picrotoxin; Strychnine | 1966 |
Spontaneous and evoked release of prostaglandins from cerebral cortex of anesthetized cats.
Topics: Animals; Biological Assay; Bromine; Cats; Cerebral Cortex; Chromatography, Thin Layer; Chymotrypsin; Corpus Callosum; Cyanates; In Vitro Techniques; Intestine, Small; Muscle, Smooth; Pentylenetetrazole; Picrotoxin; Prostaglandins; Solubility | 1966 |
Elevation of gamma-aminobutyric acid in brain with amino-oxyacetic acid and susceptibility to convulsive seizures in mice: a quantitative re-evaluation.
Topics: Acetates; Adenosine Triphosphate; Aminobutyrates; Animals; Brain; Carboxy-Lyases; Electroconvulsive Therapy; In Vitro Techniques; Mice; Nerve Endings; Pentylenetetrazole; Picrotoxin; Seizures; Strychnine | 1966 |
Time-dependent processes in memory storage.
Topics: Animals; Electric Stimulation; Electroshock; Heterocyclic Compounds; Memory; Pentylenetetrazole; Picrotoxin; Rats; Stress, Physiological; Strychnine; Time | 1966 |
The effect of convulsant drugs on transmission through the cuneate nucleus.
Topics: Animals; Blood Pressure; Cats; Electroencephalography; Medulla Oblongata; Mephenesin; Pentylenetetrazole; Picrotoxin; Strychnine | 1966 |
Effect of certain drugs on the gamma-amino-butyric acid system of the central nervous system.
Topics: Amino Alcohols; Aminobutyrates; Amobarbital; Animals; Brain; Butyrophenones; Caffeine; Carboxy-Lyases; Hypnotics and Sedatives; In Vitro Techniques; Meprobamate; Methylphenidate; Pentylenetetrazole; Picrotoxin; Rats; Subcellular Fractions; Transaminases | 1966 |
Drug effects on the spontaneous electrical activity of the squid giant axon.
Topics: Acetylcholine; Action Potentials; Animals; Anticonvulsants; Atropine; Axons; Barbiturates; Bromides; Chloroform; Chlorpheniramine; Chlorpromazine; Curare; Dopamine; Electrophysiology; Ethanol; Ethers; Evoked Potentials; Hydantoins; Mollusca; Muscles; Nortropanes; Parasympatholytics; Pentylenetetrazole; Phenobarbital; Phenytoin; Picrotoxin; Procaine; Serotonin; Strychnine; Tetracaine; Tremorine; Trihexyphenidyl; Trimethadione | 1967 |
Delay or inhibition of convulsions by intraperitoneal injections of diverse substances.
Topics: Alanine; Aminobutyrates; Animals; Atmospheric Pressure; Brain Chemistry; Hypertonic Solutions; Injections, Intraperitoneal; Male; Organ Size; Oxygen; Pentylenetetrazole; Picrotoxin; Potassium; Rats; Seizures; Sodium; Sodium Chloride; Strychnine; Succinates; Sucrose; Urea | 1967 |
Inhibition of evoked potentials by caudate stimulation and its antagonism by centrally acting drugs.
Topics: Amphetamine; Amygdala; Animals; Bemegride; Caffeine; Cats; Caudate Nucleus; Cerebral Cortex; Chlorpromazine; Electric Stimulation; Electrophysiology; Evoked Potentials; Forelimb; Hippocampus; Hypothalamus; Imipramine; Medulla Oblongata; Mephenesin; Morphine; Neurons; Pentobarbital; Pentylenetetrazole; Picrotoxin; Reticular Formation; Strychnine; Thalamus | 1967 |
Pro- and anti-convulsant properties of PK 11195, a ligand for benzodiazepine binding sites: development of tolerance.
Topics: Animals; Anticonvulsants; Benzodiazepinones; Convulsants; Diazepam; Drug Interactions; Drug Tolerance; Isoquinolines; Ligands; Male; Mice; Pentylenetetrazole; Picrotoxin; Receptors, GABA-A; Seizures; Strychnine | 1984 |
Interaction between delta-9-tetrahydrocannabinol and kindling by electrical and chemical stimuli in mice.
Topics: Animals; Dronabinol; Drug Interactions; Electric Stimulation; Electroshock; Kindling, Neurologic; Male; Mice; Pentylenetetrazole; Picrotoxin; Seizures; Stimulation, Chemical; Time Factors | 1984 |
Decreased convulsant potency of picrotoxin and pentetrazol and enhanced [3H]flunitrazepam cortical binding following stressful manipulations in rats.
Topics: Animals; Anti-Anxiety Agents; Cerebral Cortex; Diazepam; Flunitrazepam; GABA Antagonists; gamma-Aminobutyric Acid; Isoniazid; Male; Muscimol; Pentylenetetrazole; Picrotoxin; Rats; Seizures; Stress, Physiological; Thiosemicarbazones | 1980 |
Effect of repeated electroconvulsive shocks (ECS) on subthreshold doses of some CNS stimulants.
Topics: Animals; Central Nervous System Stimulants; Electroshock; Male; Mice; Pentylenetetrazole; Picrotoxin; Seizures | 1980 |
Dose-dependence of the effect of hydralazine on the central nervous system in rats.
Topics: Animals; Central Nervous System; Dose-Response Relationship, Drug; Hydralazine; Male; Pentylenetetrazole; Picrotoxin; Rats; Rats, Inbred Strains; Seizures; Time Factors | 1983 |
omega-Aminosulfonic acids as depressant or excitant compounds: their effect on the behavior and electroencephalogram of young chickens.
Topics: Alkanesulfonates; Alkanesulfonic Acids; Animals; Behavior, Animal; Central Nervous System Depressants; Central Nervous System Stimulants; Chickens; Electroencephalography; gamma-Aminobutyric Acid; Pentylenetetrazole; Picrotoxin; Structure-Activity Relationship; Strychnine; Taurine; Tubocurarine | 1983 |
[Effects of pentylenetetrazol on conflict behavior and interactions with anxiolytics in rats].
Topics: Animals; Anti-Anxiety Agents; Bicuculline; Conflict, Psychological; Diazepam; Dose-Response Relationship, Drug; Male; Pentylenetetrazole; Picrotoxin; Rats; Rats, Inbred Strains | 1983 |
Pharmacologic analysis of sodium valproate-induced suppression of secondary components of visual evoked potentials in albino rats.
Topics: Animals; Benzodiazepinones; Convulsants; Drug Interactions; Evoked Potentials, Visual; Female; gamma-Aminobutyric Acid; Male; Naloxone; Pentylenetetrazole; Photic Stimulation; Picrotoxin; Rats; Synaptic Transmission; Time Factors; Valproic Acid | 1981 |
Repeated administration of subconvulsant doses of GABA antagonist drugs. I. Effect on seizure threshold (kindling).
Topics: Animals; Bicuculline; Electroshock; GABA Antagonists; Kindling, Neurologic; Male; Pentylenetetrazole; Picrotoxin; Rats; Rats, Inbred Strains; Receptors, Cell Surface; Receptors, Drug; Receptors, GABA-A; Seizures | 1982 |
Classification of some GABA antagonists with regard to site of action and potency in slices of rat cuneate nucleus.
Topics: Animals; Bicuculline; Cyclic P-Oxides; Furosemide; GABA Antagonists; In Vitro Techniques; Medulla Oblongata; Organophosphorus Compounds; Pentylenetetrazole; Picrotoxin; Rats; Receptors, Cell Surface; Receptors, GABA-A; Strychnine; Tubocurarine | 1982 |
Effects of GABAergic agonists and antagonists on various ethanol-induced behavioral changes.
Topics: Animals; Behavior, Animal; Bicuculline; Body Temperature Regulation; Dose-Response Relationship, Drug; Ethanol; Female; Motor Activity; Muridae; Muscimol; Oxazoles; Pentylenetetrazole; Picrotoxin; Receptors, Cell Surface; Receptors, GABA-A; Seizures; Sleep Stages; Strychnine | 1982 |
Further characterization of the anorexic action of orally-administered THIP, a GABA-analogue, in the rat.
Topics: Administration, Oral; Animals; Bicuculline; Eating; gamma-Aminobutyric Acid; Isoxazoles; Male; Oxazoles; Pentylenetetrazole; Picrotoxin; Rats; Rats, Inbred Strains; Receptors, Cell Surface; Receptors, GABA-A; Strychnine | 1982 |
Development of the differential effect of oxazepam on spontaneous and activated motility in chick embryos.
Topics: Animals; Brain; Chick Embryo; Movement; Oxazepam; Pentylenetetrazole; Picrotoxin; Receptors, Cell Surface; Receptors, GABA-A; Strychnine | 1983 |
Bidirectional effects of benzodiazepine receptor ligands against picrotoxin- and pentylenetetrazol-induced seizures.
Topics: Animals; Anticonvulsants; Benzodiazepinones; Brain; Convulsants; Dose-Response Relationship, Drug; Flumazenil; Lorazepam; Male; Muridae; Pentylenetetrazole; Picrotoxin; Receptors, Cell Surface; Receptors, GABA-A; Seizures | 1983 |
On the convulsant action of Ro 5-4864 and the existence of a micromolar benzodiazepine binding site in rat brain.
Topics: Animals; Benzodiazepinones; Binding Sites; Brain; Convulsants; Diazepam; Electroshock; Flumazenil; Male; Mice; Pentylenetetrazole; Picrotoxin; Rats; Rats, Inbred Strains; Receptors, Cell Surface; Receptors, GABA-A; Seizures | 1984 |
Interactions of pentamethylenetetrazole and tetrazole analogues with the picrotoxinin site of the benzodiazepine-GABA receptor-ionophore complex.
Topics: Animals; Azoles; Binding Sites; Brain; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Bridged-Ring Compounds; Drug Interactions; Ionophores; Male; Pentylenetetrazole; Picrotoxin; Rats; Rats, Inbred Strains; Receptors, Cell Surface; Receptors, GABA-A; Sesterterpenes; Tetrazoles | 1984 |
Proconvulsant action of CGS 8216.
Topics: Animals; Benzodiazepinones; Convulsants; Drug Synergism; Flumazenil; Male; Mice; Pentylenetetrazole; Picrotoxin; Pyrazoles; Seizures | 1983 |
Tolerance to the anti-pentylenetetrazole effects of diazepam in the mouse.
Topics: Animals; Diazepam; Dose-Response Relationship, Drug; Drug Tolerance; Male; Mice; Pentylenetetrazole; Picrotoxin; Time Factors | 1983 |
Effect of prostaglandin synthetase inhibitors on experimentally induced convulsions in rats.
Topics: Animals; Anticonvulsants; Bicuculline; Cyclooxygenase Inhibitors; Electroshock; Female; Hindlimb; Pentylenetetrazole; Picrotoxin; Rats; Rats, Inbred Strains; Seizures | 1984 |
Differential effects of picrotoxin- and pentylenetetrazol-induced convulsions on the secretion of luteinizing hormone and follicle-stimulating hormone in rats.
Topics: Animals; Calcium; Female; Follicle Stimulating Hormone; Luteinizing Hormone; Male; Pentylenetetrazole; Picrotoxin; Pituitary Gland, Anterior; Rats; Rats, Inbred Strains; Seizures | 1984 |
[Effect of sodium dipropylacetate on experimental convulsions produced by pentetrazole and picrotoxin].
Topics: Animals; Male; Mice; Pentylenetetrazole; Picrotoxin; Seizures; Valproic Acid | 1981 |
Synergistic anticonvulsant effects of GABA-T inhibitors and glycine.
Topics: 3-Mercaptopropionic Acid; 4-Aminobutyrate Transaminase; Amino Acids; Aminocaproates; Aminooxyacetic Acid; Animals; Anticonvulsants; Bicuculline; Brain Chemistry; Drug Synergism; Ethanolamines; Glycine; Male; Mice; Pentylenetetrazole; Picrotoxin; Rats; Rats, Inbred Strains; Sesterterpenes; Strychnine; Vigabatrin | 1984 |
Do the reductions in social interaction produced by picrotoxin and pentylenetetrazole indicate anxiogenic actions?
Topics: Animals; Arousal; Chlordiazepoxide; Corticosterone; Dose-Response Relationship, Drug; Male; Motor Activity; Pentylenetetrazole; Picrotoxin; Rats; Social Behavior | 1984 |
Anticonvulsant activity of the nipecotic acid ester, (+/-)-m-nitrophenyl-3-piperidinecarboxylate.
Topics: Animals; Anticonvulsants; Bicuculline; gamma-Aminobutyric Acid; Isoniazid; Male; Nipecotic Acids; Pentylenetetrazole; Picrotoxin; Rats; Rats, Inbred Strains; Seizures | 1984 |
Convulsant-induced depression of amino acid responses in cultured mouse spinal neurones studied under voltage clamp.
Topics: Amino Acids; Animals; Bicuculline; Cells, Cultured; Convulsants; GABA Antagonists; Glycine; Membrane Potentials; Mice; Neurons; Pentylenetetrazole; Picrotoxin; Spinal Cord; Strychnine | 1983 |
Denzimol, a new anticonvulsant drug. I. General anticonvulsant profile.
Topics: Animals; Anticonvulsants; Electroencephalography; Electroshock; Female; Imidazoles; Male; Mice; Motor Activity; Pentylenetetrazole; Picrotoxin; Procaine; Rabbits; Rats; Rats, Inbred Strains; Seizures; Species Specificity | 1983 |
Interactions of two phenylquinolines with picrotoxin and benzodiazepines in vivo and in vitro.
Topics: Animals; Anticonvulsants; Benzodiazepines; Drug Interactions; gamma-Aminobutyric Acid; Male; Mice; Muscimol; Myoclonus; Pentylenetetrazole; Picrotoxin; Quinolines; Rats; Rats, Inbred Strains; Seizures | 1984 |
Convulsant-specific architecture of the postictal behavior syndrome in the rat.
Topics: Animals; Behavior, Animal; Benzodiazepinones; Catatonia; Convulsants; Disease Models, Animal; Electroshock; Epilepsy, Tonic-Clonic; Female; Humans; Kindling, Neurologic; Male; Pentylenetetrazole; Picrotoxin; Rats; Seizures | 1981 |
Selective blockade of the discriminative stimulus effects of pentobarbital in pigeons.
Topics: Animals; Bemegride; Columbidae; Discrimination, Psychological; GABA Antagonists; Pentobarbital; Pentylenetetrazole; Picrotoxin; Stimulation, Chemical | 1981 |
Anticonvulsant and antiaggressive properties of di-n-propyl acetate after repeated treatment.
Topics: Acoustic Stimulation; Aggression; Animals; Anticonvulsants; Brain; Female; gamma-Aminobutyric Acid; Humans; Male; Mice; Pentylenetetrazole; Picrotoxin; Rats; Rats, Inbred Strains; Seizures; Time Factors; Valproic Acid | 1982 |
Repeated administration of subconvulsant doses of GABA antagonist drugs. II. Effect on monoamine-mediated behaviour.
Topics: Animals; Apomorphine; Behavior, Animal; Bicuculline; GABA Antagonists; Humans; Kindling, Neurologic; Male; Methamphetamine; Motor Activity; Pentylenetetrazole; Picrotoxin; Quipazine; Rats; Rats, Inbred Strains; Receptors, Dopamine; Receptors, Serotonin; Stereotyped Behavior | 1982 |
Pharmacological investigation of convulsant gamma-aminobutyric acid (GABA) antagonists in amygdala-kindled rats.
Topics: Amygdala; Animals; Convulsants; Drug Synergism; GABA Antagonists; gamma-Aminobutyric Acid; Kindling, Neurologic; Male; Pentylenetetrazole; Picrotoxin; Rats; Rats, Inbred Strains; Seizures | 1982 |
Antagonism of gamma-aminobutyric acid and muscimol by picrotoxin, bicuculline, strychnine, bemegride, leptazol, D-tubocurarine and theophylline in the isolated olfactory cortex.
Topics: Animals; Bicuculline; GABA Antagonists; Guinea Pigs; In Vitro Techniques; Muscimol; Olfactory Bulb; Oxazoles; Pentylenetetrazole; Picrotoxin; Strychnine; Theophylline; Tubocurarine | 1982 |
Investigations of new structures with pharmacological activity. II: Anticonvulsant properties of benzocyclobutenols and benzocylenones.
Topics: Animals; Anticonvulsants; Electroshock; Female; Isoniazid; Lethal Dose 50; Male; Mice; Motor Activity; Pentylenetetrazole; Picrotoxin; Polycyclic Compounds | 1981 |
Pharmacologic analysis of the postictal immobility syndrome in the rat.
Topics: Animals; Behavior, Animal; Electroencephalography; Electroshock; Epilepsy; Female; Haloperidol; Motor Activity; Pentylenetetrazole; Picrotoxin; Rats; Rats, Inbred Strains; Seizures; Time Factors | 1981 |
Effects of anticonvulsants and glutamate antagonists on the convulsive action of kainic acid.
Topics: 3-Mercaptopropionic Acid; Animals; Anticonvulsants; Bemegride; Bicuculline; Drug Interactions; Excitatory Amino Acid Antagonists; Kainic Acid; Male; Mice; Pentylenetetrazole; Picrotoxin; Pyrrolidines; Seizures | 1980 |
Ketamine: convulsant or anti-convulsant?
Topics: Animals; Anticonvulsants; Convulsants; Drug Interactions; Electroencephalography; Ketamine; Male; Pentylenetetrazole; Picrotoxin; Rats | 1981 |
Chronic administration of a nitric oxide synthase inhibitor, N omega-nitro-L-arginine, and drug-induced increase in cerebellar cyclic GMP in vivo.
Topics: Amino Acid Oxidoreductases; Animals; Arginine; Cerebellum; Cyclic GMP; Drug Interactions; Glutamates; Glutamic Acid; Harmaline; Male; Mice; Nitric Oxide Synthase; Nitroarginine; Pentylenetetrazole; Picrotoxin | 1993 |
Clinical signs of ivermectin toxicity and the efficacy of antigabaergic convulsants as antidotes for ivermectin poisoning in epileptic chickens.
Topics: Animals; Antidotes; Carbolines; Chickens; Epilepsy; GABA Antagonists; Ivermectin; Pentylenetetrazole; Picrotoxin; Poultry Diseases | 1995 |
Neonatal caffeine exposure and seizure susceptibility in adult rats.
Topics: Animals; Animals, Newborn; Bicuculline; Brain; Caffeine; Female; Kainic Acid; Male; Pentylenetetrazole; Picrotoxin; Rats; Receptors, Purinergic P1; Seizures; Sex Factors; Strychnine | 1995 |
Spontaneous bursting induced by convulsant agents in an identified insect neurone.
Topics: Animals; Convulsants; Male; Membrane Potentials; Motor Neurons; Pentylenetetrazole; Periplaneta; Picrotoxin | 1995 |
Picrotoxin and pentylene tetrazole induced seizure activity in pyridoxine-deficient rats.
Topics: Animals; Cerebral Cortex; Differential Threshold; Electroencephalography; Electronic Data Processing; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Male; Neurons; Pentylenetetrazole; Picrotoxin; Pyridoxine; Rats; Rats, Sprague-Dawley; Seizures; Thalamus; Vitamin B 6 Deficiency | 1994 |
Pharmacological studies on a new dihydrothienopyridine calcium antagonist, S-312-d. 5th communication: anticonvulsant effects in mice.
Topics: Administration, Oral; Animals; Anticonvulsants; Bemegride; Calcium Channel Blockers; Dihydropyridines; Disease Models, Animal; Electroshock; Female; Injections, Subcutaneous; Male; Mice; Mice, Inbred DBA; N-Methylaspartate; Pentylenetetrazole; Picrotoxin; Seizures | 1994 |
Modulation of the intracellular and H3-histamine receptors and chemically-induced seizures in mice.
Topics: Animals; Anticonvulsants; Behavior, Animal; Convulsants; Histamine Agonists; Histamine Antagonists; Histamine H1 Antagonists; Male; Mice; Mice, Neurologic Mutants; Pentylenetetrazole; Picrotoxin; Receptors, Histamine H3; Seizures | 1994 |
Possible participation of NMDA and glycine receptors but not GABAA receptors in enflurane-induced opisthotonus in mice.
Topics: Animals; Dizocilpine Maleate; Dose-Response Relationship, Drug; Enflurane; Male; Mice; Mice, Inbred Strains; Muscle Spasticity; Pentylenetetrazole; Picrotoxin; Receptors, GABA-A; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate; Strychnine | 1994 |
Disruption of GABA-dependent chloride flux by cyclodienes and hexachlorocyclohexanes in primary cultures of cortical neurons.
Topics: Animals; Calcium; Cells, Cultured; Cerebral Cortex; Chlorides; Endosulfan; Female; gamma-Aminobutyric Acid; Insecticides; Mice; Pentylenetetrazole; Picrotoxin; Pregnancy; Receptors, GABA-A; Sesterterpenes | 1994 |
Effects of endothelin-1 (ET-1) and endothelin-3 (ET-3) on convulsive seizures.
Topics: Animals; Anticonvulsants; Bicuculline; Endothelins; gamma-Aminobutyric Acid; Injections, Intraventricular; Male; Mice; Pentylenetetrazole; Picrotoxin; Seizures; Strychnine | 1994 |
Effects of desipramine and alprazolam in the forced swim test in rats after long-lasting termination of chronic exposure to picrotoxin and pentylenetetrazol.
Topics: Alprazolam; Animals; Chlordiazepoxide; Desipramine; GABA-A Receptor Antagonists; Male; Motor Activity; Pentylenetetrazole; Picrotoxin; Psychomotor Performance; Rats; Substance Withdrawal Syndrome; Swimming | 1993 |
Behavioural and electroencephalographic effects of Tityus serrulatus scorpion venom in rats.
Topics: Animals; Behavior, Animal; Convulsants; Dose-Response Relationship, Drug; Electrodes; Electroencephalography; Epilepsy; Hippocampus; Male; Microinjections; Pentylenetetrazole; Picrotoxin; Rats; Rats, Wistar; Scorpion Venoms | 1993 |
Ethosuximide suppresses seizures and lethality induced by picrotoxin in developing rats.
Topics: Animals; Anticonvulsants; Behavior, Animal; Epilepsies, Myoclonic; Epilepsy, Tonic-Clonic; Ethosuximide; Male; Pentylenetetrazole; Picrotoxin; Rats; Rats, Wistar; Seizures | 1993 |
Non-psychostimulant drugs of abuse and anxiogenic drugs activate with differential selectivity dopamine transmission in the nucleus accumbens and in the medial prefrontal cortex of the rat.
Topics: Animals; Carbolines; Convulsants; Dopamine; Ethanol; Male; Morphine; Nicotine; Nucleus Accumbens; Pentylenetetrazole; Picrotoxin; Prefrontal Cortex; Rats; Rats, Sprague-Dawley | 1996 |
Distinct effects of N omega-nitro-L-arginine on seizures induced by several drugs in mice.
Topics: Animals; Arginine; Bicuculline; Dose-Response Relationship, Drug; Male; Mice; Mice, Inbred ICR; Pentylenetetrazole; Picrotoxin; Seizures; Time Factors | 1996 |
Concentration of putrescine in plasma, frontal cortex and hippocampus of rats after systemic administration of the convulsants N-methyl-D-aspartate, pentylentetrazol, picrotoxinine, lindane and 4-aminopyridine.
Topics: Aminopyrine; Analysis of Variance; Animals; Convulsants; Drug Evaluation, Preclinical; Evaluation Studies as Topic; Excitatory Amino Acid Agonists; Frontal Lobe; Hexachlorocyclohexane; Hippocampus; Kainic Acid; Male; N-Methylaspartate; Pentylenetetrazole; Picrotoxin; Putrescine; Rats; Rats, Wistar; Sesterterpenes | 1996 |
Susceptibility to drug-induced seizures of Fyn tyrosine kinase-deficient mice.
Topics: Animals; Bicuculline; Mice; Mice, Inbred Strains; Pentylenetetrazole; Picrotoxin; Protein-Tyrosine Kinases; Seizures | 1996 |
Stimulatory effect of diazepam on gastric acid secretion in the continuously perfused stomach in rats under urethane anesthesia.
Topics: 3-Mercaptopropionic Acid; Analysis of Variance; Anesthetics, Intravenous; Animals; Atropine; Diazepam; Flumazenil; GABA Agents; GABA Antagonists; GABA Modulators; GABA-A Receptor Agonists; Gastric Acid; Gastric Mucosa; Hexamethonium; Isoquinolines; Male; Parasympatholytics; Pentylenetetrazole; Picrotoxin; Pylorus; Rats; Rats, Wistar; Receptors, GABA; Urethane; Vagotomy | 1997 |
Chinese herb constituent beta-eudesmol alleviated the electroshock seizures in mice and electrographic seizures in rat hippocampal slices.
Topics: Animals; Dose-Response Relationship, Drug; Drug Synergism; Drug Therapy, Combination; Drugs, Chinese Herbal; Electroshock; Hippocampus; In Vitro Techniques; Male; Mice; Mice, Inbred ICR; Pentylenetetrazole; Phenytoin; Picrotoxin; Potassium; Rats; Seizures; Sesquiterpenes, Eudesmane; Terpenes | 1997 |
Comparative in vivo and in vitro studies with the potent GABAB receptor antagonist, CGP 56999A.
Topics: Animals; Baclofen; Cerebral Cortex; Convulsants; Dose-Response Relationship, Drug; Drug Interactions; GABA Antagonists; GABA-B Receptor Antagonists; In Vitro Techniques; Injections, Intraperitoneal; Male; Mice; Neurons; Pentylenetetrazole; Phosphinic Acids; Picrotoxin; Pyramidal Cells; Rats; Rats, Sprague-Dawley; Receptors, GABA-B; Seizures; Stereotyped Behavior | 1997 |
Further studies on anti- and proconvulsant effects of inhibitors of nitric oxide synthase in rodents.
Topics: Animals; Anticonvulsants; Convulsants; Enzyme Inhibitors; Male; Mice; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Nitroarginine; Pentylenetetrazole; Picrotoxin; Rats; Rats, Sprague-Dawley; Rats, Wistar; Seizures | 1998 |
[S]-AR-R 15896AR-A novel anticonvulsant: acute safety, pharmacokinetic and pharmacodynamic properties.
Topics: 4-Aminopyridine; Animals; Anticonvulsants; Bicuculline; Electric Stimulation; Kainic Acid; Male; Mice; N-Methylaspartate; Pentylenetetrazole; Picrotoxin; Pyridines; Rats; Rats, Sprague-Dawley; Seizures; Seizures, Febrile; Strychnine; Time Factors; Weaning | 1999 |
Forebrain ischemia: effect on pharmacologically induced seizure thresholds in the rat.
Topics: Analysis of Variance; Animals; Brain Ischemia; Convulsants; Lidocaine; Male; N-Methylaspartate; Pentylenetetrazole; Picrotoxin; Prosencephalon; Rats; Rats, Sprague-Dawley; Seizures | 1999 |
Roles of group II metabotropic glutamate receptors in modulation of seizure activity.
Topics: Analysis of Variance; Animals; Anti-Anxiety Agents; Brain; Bridged Bicyclo Compounds; Convulsants; Diazepam; Dose-Response Relationship, Drug; Drug Combinations; Electrophysiology; Male; Mice; N-Methylaspartate; Pentylenetetrazole; Picrotoxin; Rats; Rats, Wistar; Receptors, Metabotropic Glutamate; Seizures | 2000 |
Design and synthesis of anticonvulsive agents as gamma-vinyl GABA-based potential dual acting prodrugs and their biological activities.
Topics: Animals; Anticonvulsants; Bicuculline; Drug Design; Mice; Pentylenetetrazole; Picrotoxin; Prodrugs; Seizures; Vigabatrin | 2000 |
Chemical kindling and seizure susceptibility in morphine dependent rats.
Topics: Animals; Caffeine; Convulsants; Disease Models, Animal; Drug Interactions; Excitatory Amino Acid Agonists; GABA Antagonists; Kindling, Neurologic; Male; Morphine; Morphine Dependence; N-Methylaspartate; Pentylenetetrazole; Picrotoxin; Rats; Rats, Wistar; Receptors, GABA; Receptors, Purinergic P1; Seizures | 2000 |
Pentylenetetrazole-induced inhibition of recombinant gamma-aminobutyric acid type A (GABA(A)) receptors: mechanism and site of action.
Topics: Algorithms; Animals; Cell Line; Cloning, Molecular; Convulsants; Electrophysiology; GABA Antagonists; GABA-A Receptor Antagonists; Humans; Kinetics; Oocytes; Patch-Clamp Techniques; Pentylenetetrazole; Picrotoxin; Xenopus | 2001 |
Anticonvulsant activities of the FS-1 subfraction isolated from roots of Delphinium denudatum.
Topics: Animals; Anticonvulsants; Bicuculline; Dose-Response Relationship, Drug; Electroshock; Epilepsy, Generalized; Magnoliopsida; Male; Mice; Muscle Contraction; Pentylenetetrazole; Picrotoxin; Plant Extracts; Plant Roots; Plants, Medicinal | 2001 |
Anticonvulsant activities of ethanolic extract and aqueous fraction isolated from Delphinium denudatum.
Topics: Animals; Anticonvulsants; Bicuculline; Convulsants; Electroshock; Ethanol; Male; Mice; Pentylenetetrazole; Picrotoxin; Ranunculaceae; Solvents; Strychnine; Water | 2001 |
Anticonvulsant activity of aqueous extract of Leonotis leonurus.
Topics: Animals; Anticonvulsants; Bicuculline; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Lamiaceae; Male; Mice; N-Methylaspartate; Pentylenetetrazole; Phytotherapy; Picrotoxin; Plant Extracts; Seizures | 2002 |
Anticonvulsive activity of Butea monosperma flowers in laboratory animals.
Topics: Animals; Anticonvulsants; Behavior, Animal; Butea; Convulsants; Dyskinesia, Drug-Induced; Electroshock; Flowers; Lithium; Male; Pentylenetetrazole; Picrotoxin; Pilocarpine; Postural Balance; Rats; Rats, Sprague-Dawley; Seizures; Strychnine | 2002 |
Changes of cortical epileptic afterdischarges under the influence of convulsant drugs.
Topics: Animals; Caffeine; Cerebral Cortex; Convulsants; Electric Stimulation; Electroencephalography; Epilepsy, Tonic-Clonic; Male; Pentylenetetrazole; Phosphodiesterase Inhibitors; Picrotoxin; Rats; Rats, Wistar | 2002 |
Status epilepticus induced by lithium-pilocarpine in the immature rat does not change the long-term susceptibility to seizures.
Topics: Aging; Animals; Animals, Newborn; Cerebellar Cortex; Disease Models, Animal; Disease Susceptibility; Dose-Response Relationship, Drug; Electroencephalography; Excitatory Amino Acid Agonists; Female; GABA Antagonists; GABA-A Receptor Antagonists; Kainic Acid; Lithium; Male; Muscarinic Agonists; Pentylenetetrazole; Picrotoxin; Pilocarpine; Rats; Rats, Sprague-Dawley; Reaction Time; Status Epilepticus | 2002 |
CNS inhibitory effects of barakol, a constituent of Cassia siamia Lamk.
Topics: Animals; Anticonvulsants; Benzopyrans; Bicuculline; Cassia; Diazepam; Dopamine; Dose-Response Relationship, Drug; Male; Maze Learning; Methamphetamine; Pentylenetetrazole; Phenalenes; Phytotherapy; Picrotoxin; Plant Extracts; Rats; Rats, Wistar; Seizures; Sleep; Strychnine; Thiopental | 2002 |
The GABA(A) receptor antagonist picrotoxin inhibits 5-hydroxytryptamine type 3A receptors.
Topics: Animals; Cell Line; GABA Antagonists; GABA-A Receptor Antagonists; Humans; Ligands; Mice; Pentylenetetrazole; Picrotoxin; Quinoxalines; Receptors, Serotonin; Receptors, Serotonin, 5-HT3; Serotonin Antagonists | 2003 |
Neurochemical characteristics of the ventromedial hypothalamus in mediating the antiaversive effects of anxiolytics in different models of anxiety.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Animals; Anti-Anxiety Agents; Anticonvulsants; Anxiety; Apomorphine; Avoidance Learning; Biguanides; Brain Chemistry; Chlordiazepoxide; Clonidine; Disease Models, Animal; Dopamine; Dopamine Agonists; Dopamine Antagonists; Dose-Response Relationship, Drug; Droperidol; Drug Interactions; GABA Agents; GABA Antagonists; GABA Modulators; gamma-Aminobutyric Acid; Glutamic Acid; Male; Memantine; Mephenytoin; Microinjections; Pentylenetetrazole; Phentolamine; Picrotoxin; Piperazines; Propranolol; Pyrimidines; Rats; Serotonin; Sulpiride; Ventromedial Hypothalamic Nucleus; Yohimbine | 2003 |
Central properties of the essential oil and the crude ethanol extract from aerial parts of Artemisia annua L.
Topics: Animals; Anticonvulsants; Artemisia; Central Nervous System Agents; Convulsants; Ethanol; Gas Chromatography-Mass Spectrometry; Lethal Dose 50; Male; Mice; Oils, Volatile; Pentylenetetrazole; Picrotoxin; Pilocarpine; Plant Extracts; Plant Leaves; Postural Balance; Rats; Rats, Wistar; Seizures; Solvents; Strychnine | 2003 |
[The point of peripheral impact of coramine, cardiazol, picrotoxin and scilliroside and their relation to cholinergic action. I].
Topics: Bufanolides; Cholinergic Agents; Disease; Epilepsy; Muscles; Nikethamide; Pentylenetetrazole; Picrotoxin; Plants, Medicinal; Vagus Nerve | 1953 |
[Effect of drugs on the metabolism of pyruvate in fetuses and young animals. I. Nerve excitants].
Topics: Animals; Caffeine; Camphor; Central Nervous System; Fetus; Liver; Pentylenetetrazole; Picrotoxin; Pyruvates; Pyruvic Acid; Strychnine | 1953 |
[Case of severe luminal poisoning].
Topics: Barbiturates; Humans; Pentylenetetrazole; Picrotoxin | 1956 |
The effect of analeptics on arterial blood gases of dogs during barbiturate anesthesia.
Topics: Anesthesia; Animals; Barbiturates; Blood Gas Analysis; Carbon Dioxide; Central Nervous System Stimulants; Dogs; Oxygen; Pentylenetetrazole; Picrotoxin; Urethane | 1956 |
A comparative study of bemegride (beta, beta-methylethyl glutarimide; NP-13; Megimide) as an analeptic in mice.
Topics: Animals; Bemegride; Central Nervous System Stimulants; Mice; Pentylenetetrazole; Picrotoxin; Piperidones | 1957 |
[Behavior of experimental catatonia induced by bulbocapnine in rats under the action of various drugs. VI. Action of camphor, coramine, cardiazol, picrotoxin, caffeine and strychnine].
Topics: Alkaloids; Animals; Aporphines; Caffeine; Camphor; Catatonia; Nikethamide; Pentylenetetrazole; Picrotoxin; Rats; Strychnine | 1957 |
[Comparative experiments with beta-methyl-beta-ethylglutarimide, pentamethylenetetrazol, and picrotoxin on EEG & blood pressure in cats].
Topics: Animals; Blood Pressure; Blood Pressure Determination; Cats; Central Nervous System Stimulants; Electroencephalography; Pentylenetetrazole; Picrotoxin | 1957 |
Drugs which stimulate affective behaviour. 3. Comparison of the effect of picrotoxin, pentylenetetrazol, bemigride, pipradrol, ectylurea, vanillic acid diethylamide and deanol.
Topics: Amides; Central Nervous System Stimulants; Deanol; Pentylenetetrazole; Picrotoxin; Piperidines; Psychopharmacology; Vanillic Acid | 1960 |
Intravenous, cortical and intraventricular dose-effect relationship of pentylenetetrazol, picrotoxin and deslanoside in dogs.
Topics: Administration, Intravenous; Animals; Cardiac Glycosides; Deslanoside; Dogs; Electroencephalography; Glycosides; Pentylenetetrazole; Picrotoxin | 1962 |
[Comparative studies on the convulsive action of bemegrid, pentetrazol and picrotoxin].
Topics: Central Nervous System Stimulants; Pentylenetetrazole; Picrotoxin; Seizures | 1962 |
[On the temperature effect and blood sugar effect of bemegride, pentylenetetrazole, and picrotoxin in normal and in barbiturate-poisoned animals].
Topics: Barbiturates; Bemegride; Blood Glucose; Body Temperature; Pentylenetetrazole; Picrotoxin; Temperature | 1963 |
[Studies on the strength of action of the analeptics bemegride, pentylenetetrazole and picrotoxin in phenobarbital-hydroxydione-ethinamate narcosis and on reciprocal antagonism].
Topics: Bemegride; Carbamates; Central Nervous System Stimulants; Hypnotics and Sedatives; Pentylenetetrazole; Phenobarbital; Picrotoxin; Pregnanediones; Stupor | 1963 |
Mechanism of cardiac arrhythmias and blood pressure changes induced in dogs by pentylenetetrazol, picrotoxin, and deslanoside.
Topics: Animals; Arrhythmias, Cardiac; Blood Pressure; Deslanoside; Dogs; Lanatosides; Pentylenetetrazole; Picrotoxin | 1963 |
Analysis of the antagonism between some brain stem stimulants and pentobarbital.
Topics: Bemegride; Brain Stem; Central Nervous System Agents; Central Nervous System Stimulants; Flavones; Pentobarbital; Pentylenetetrazole; Picrotoxin; Pyrans | 1963 |
Dimefline (Rec 7-0267), other C.N.S. stimulants and lobeline as antagonists of pentobarbital.
Topics: Amphetamine; Barbiturates; Bemegride; Benzoates; Central Nervous System Stimulants; Flavones; Flavonoids; Lobeline; Pentobarbital; Pentylenetetrazole; Picrotoxin | 1962 |
[Comparison of the pneumokinetic activity of Remeflin with that of other respiratory stimulants].
Topics: Aminobutyrates; Bemegride; Cell Respiration; Chromones; Flavones; Lobeline; Pentylenetetrazole; Picrotoxin; Respiration; Respiratory System Agents; Strychnine | 1961 |
[Influence of acetylcholine on the lethal dose of various poisons for the rat].
Topics: Acetylcholine; Ammonia; Animals; Glutamates; Nicotine; Pentylenetetrazole; Picrotoxin; Poisoning; Poisons; Rats; Sodium Chloride | 1962 |
FREE AMINO ACIDS AND RELATED COMPOUNDS IN DOG BRAIN: POST-MORTEM AND ANOXIC CHANGES, EFFECTS OF AMMONIUM CHLORIDE INFUSION, AND LEVELS DURING SEIZURES INDUCED BY PICROTOXIN AND BY PENTYLENETETRAZOL.
Topics: Amino Acids; Ammonium Chloride; Autopsy; Brain; Dogs; Hypoxia; Pathology; Pentylenetetrazole; Pharmacology; Picrotoxin; Proteins; Research; Seizures | 1963 |
PHARMACOLOGICAL STUDIES ON PRESYNAPTIC INHIBITION.
Topics: Aminobutyrates; Barbiturates; Bemegride; Cats; Chloralose; Diphosphates; Gallamine Triethiodide; Nicotine; Pentobarbital; Pentylenetetrazole; Pharmacology; Physiology; Physostigmine; Picrotoxin; Research; Spinal Cord; Spinal Nerves; Strychnine; Sulfonic Acids; Synapses | 1963 |
NEURAL INHIBITION IN A BIRD: EFFECT OF STRYCHNINE AND PICROTOXIN.
Topics: Animals; Bemegride; Birds; Brain; Cochlea; Electrophysiological Phenomena; Electrophysiology; Injections, Intravenous; Neural Inhibition; Pentylenetetrazole; Picrotoxin; Research; Strychnine; Thiopental | 1963 |
[ACUTE POISONING WITH HYPNOTICS AND SEDATIVES].
Topics: Analgesics; Analgesics, Non-Narcotic; Antipyretics; Azoles; Barbiturates; Bemegride; Chlorpromazine; Diuretics; Hypnotics and Sedatives; Kidney; Kidneys, Artificial; Meprobamate; Pentylenetetrazole; Picrotoxin; Toxicology | 1963 |
STIMULANT ACTION OF PYRIDYL DERIVATIVES OF BENZODIOXANS AND BENZODIOXEPANS.
Topics: Animals; Anticonvulsants; Atropine; Bemegride; Central Nervous System Agents; Central Nervous System Stimulants; Chlorisondamine; Chlorpromazine; Diazepam; Mephenesin; Meprobamate; Mice; Pentylenetetrazole; Pharmacology; Phenobarbital; Phenytoin; Picrotoxin; Research; Seizures; Strychnine; Tranquilizing Agents | 1963 |
A CLINICAL APPRAISAL OF DRUGS USED FOR CARDIORESPIRATORY RESUSCITATION.
Topics: Amphetamine; Amphetamines; Barium; Bemegride; Bicarbonates; Calcium; Cyanides; Epinephrine; Humans; Isoproterenol; Lactates; Lidocaine; Lobeline; Methylphenidate; Nalorphine; Nicotine; Nikethamide; Norepinephrine; Pentylenetetrazole; Pharmacology; Picrotoxin; Potassium; Procaine; Resuscitation; Toxicology | 1964 |
[ON BARBITURATE POISONING].
Topics: Barbiturates; Diagnosis; Ephedrine; Humans; Nikethamide; Pentylenetetrazole; Picrotoxin; Strychnine; Thyroxine; Toxicology | 1964 |
SYNTHESIS AND PHARMACOLOGICAL PROPERTIES OF PHENYL-SUBSTITUTED BIURETS.
Topics: Atropine; Biuret; Chemistry, Pharmaceutical; Gastric Juice; Meprobamate; Mice; Nicotine; Pentylenetetrazole; Peptic Ulcer; Pharmacology; Phenformin; Phenobarbital; Picrotoxin; Rats; Research; Seizures; Strychnine; Toxicology; Urea | 1963 |
THE HISTOMORPHOLOGY OF EXPERIMENTAL EXCITATION.
Topics: Acridines; Coloring Agents; Depression; Depressive Disorder; Hippocampus; Histology; Lysergic Acid Diethylamide; Neuroglia; Pentobarbital; Pentylenetetrazole; Picrotoxin; Rats; Research; Seizures; Staining and Labeling; Toxicology | 1964 |
[A STUDY OF THE ANTICONVULSANT PROPERTIES OF THE KAWA PYRONES DIHYDROMETHYSTICIN (DHM) AND DIHYROKAWAIN (DHK) IN CHEMICALLY INDUCED CONCLUSIONS].
Topics: Anticonvulsants; Bemegride; Kava; Mice; Pentylenetetrazole; Pharmacology; Picrotoxin; Pyrans; Pyrones; Research; Strychnine; Toxicology | 1964 |
CARDIAC EFFECTS OF DIMEFLINE COMPARED WITH THOSE OF OTHER CENTRAL NERVOUS SYSTEM STIMULANTS.
Topics: Aminobutyrates; Bemegride; Benzene; Calcium; Central Nervous System Stimulants; Chlorides; Coronary Vessels; Electrocardiography; Epinephrine; Flavones; Flavonoids; Guinea Pigs; Heart; Nikethamide; Pentylenetetrazole; Pharmacology; Picrotoxin; Research; Seizures; Strychnine; Toxicology; Ventricular Fibrillation | 1964 |
EXPERIMENTAL AND CLINICAL BARBITURATE ANTAGONISM.
Topics: Barbiturates; Bemegride; Mice; Pentobarbital; Pentylenetetrazole; Pharmacology; Picrotoxin; Pregnanediones; Research; Toxicology | 1964 |
ASSAY OF CONVULSANTS USING SINGLE UNIT ACTIVITY.
Topics: Central Nervous System Stimulants; Convulsants; Electrophysiology; Ganglia; Methionine; Mollusca; Neurons; Pentylenetetrazole; Pharmacology; Picrotoxin; Research; Strychnine | 1965 |
EFFECTS OF HEXAMETHONIUM AND TETRAETHYLAMMONIUM ON CARDIAC ARRHYTHMIAS PRODUCED BY PENTYLENETETRAZOL, PICROTOXIN AND DESLANOSIDE IN DOGS.
Topics: Animals; Arrhythmias, Cardiac; Autonomic Nervous System; Central Nervous System; Deslanoside; Dogs; Electrocardiography; Ganglia; Ganglia, Autonomic; Hexamethonium; Hexamethonium Compounds; Lanatosides; Pentylenetetrazole; Pharmacology; Physiology; Picrotoxin; Research; Tetraethylammonium; Tetraethylammonium Compounds; Toxicology | 1965 |
[ON THE INFLUENCE OF FLUID VOLUME ON THE EFFICACY OF BEMEGRIDE, PENTETRAZOL AND PICROTOXIN IN BARBITAL INTOXICATION].
Topics: Barbital; Barbiturates; Bemegride; Central Nervous System Stimulants; Dosage Forms; Mice; Pentylenetetrazole; Picrotoxin; Research; Toxicology | 1965 |
[Grave barbituric coma after administration of 800 mg. of picrotoxin and 20 gm. of pentmethylenetetrazole in 44 hours].
Topics: Coma; Humans; Pentylenetetrazole; Picrotoxin; Poisoning; Suicide | 1955 |
Increase in drug-induced seizure susceptibility of transgenic mice overexpressing GABA transporter-1.
Topics: Animals; Animals, Genetically Modified; Anticonvulsants; Carrier Proteins; Disease Models, Animal; Female; GABA Plasma Membrane Transport Proteins; Genetic Predisposition to Disease; Kainic Acid; Male; Membrane Proteins; Membrane Transport Proteins; Mice; Mice, Inbred C57BL; Nipecotic Acids; Pentylenetetrazole; Picrotoxin; Seizures | 2003 |
Differential sensitivity of genetically Fast vs. Slow kindling rats strains to GABAergic convulsive agents.
Topics: Animals; Bicuculline; Convulsants; Dose-Response Relationship, Drug; Female; GABA Antagonists; gamma-Aminobutyric Acid; Glycine Agents; Kindling, Neurologic; Male; Pentylenetetrazole; Picrotoxin; Rats; Rats, Long-Evans; Rats, Wistar; Species Specificity; Strychnine | 2003 |
[Intoxication with barbiturates; 7 cases of grave coma treated with picrotoxin, metrazole and carbogen].
Topics: Ascomycota; Barbital; Barbiturates; Carbon Dioxide; Coma; Humans; Oxygen; Pentylenetetrazole; Picrotoxin | 1951 |
Inhibitory effects of the essential oil from SuHeXiang Wan on the central nervous system after inhalation.
Topics: 4-Aminobutyrate Transaminase; Administration, Inhalation; Animals; Anticonvulsants; Antioxidants; Brain; Brain Chemistry; Drugs, Chinese Herbal; Glutamic Acid; Lipid Peroxidation; Male; Mice; Mice, Inbred ICR; Oils, Volatile; Pentylenetetrazole; Phytotherapy; Picrotoxin; Receptors, GABA-A; Seizures; Sleep; Strychnine | 2004 |
Anticonvulsant activity of the testosterone-derived neurosteroid 3alpha-androstanediol.
Topics: Androgen Antagonists; Androstane-3,17-diol; Animals; Anticonvulsants; Carbolines; Convulsants; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Flutamide; Male; Mice; Mice, Inbred C57BL; Pentylenetetrazole; Picrotoxin; Receptors, Androgen; Receptors, GABA-A; Seizures; Testosterone | 2004 |
Analgesic and anticonvulsant properties of Tetrapleura tetraptera (Taub) (Fabaceae) fruit aqueous extract in mice.
Topics: Acetic Acid; Analgesics; Animals; Anticonvulsants; Bicuculline; Female; Fruit; Hot Temperature; Male; Mice; Mice, Inbred BALB C; Pain; Pentylenetetrazole; Phytotherapy; Picrotoxin; Plant Extracts; Seizures; Tetrapleura | 2005 |
Study of anticonvulsant effect of citronellol, a monoterpene alcohol, in rodents.
Topics: Action Potentials; Acyclic Monoterpenes; Analysis of Variance; Animals; Anticonvulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Electroshock; Male; Mice; Monoterpenes; Neural Conduction; Pentylenetetrazole; Picrotoxin; Reaction Time; Seizures; Time Factors | 2006 |
Anticonvulsant effect of Persea americana Mill (Lauraceae) (Avocado) leaf aqueous extract in mice.
Topics: Animals; Anticonvulsants; Bicuculline; Convulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Antagonism; Lethal Dose 50; Male; Mice; Mice, Inbred BALB C; Pentylenetetrazole; Persea; Phytotherapy; Picrotoxin; Plant Extracts; Plant Leaves; Seizures | 2006 |
Development of a Drosophila seizure model for in vivo high-throughput drug screening.
Topics: Amino Acid Sequence; Animals; Anticonvulsants; Behavior, Animal; Cell Survival; Convulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Drosophila; Drug Evaluation, Preclinical; Electrophysiology; GABA Antagonists; GABA-A Receptor Antagonists; Larva; Pentylenetetrazole; Phenotype; Phenytoin; Picrotoxin; Seizures | 2006 |
Evaluation of anticonvulsant and analgesic effects of benzyl- and benzhydryl ureides.
Topics: Analgesics; Animals; Anticonvulsants; Benzhydryl Compounds; Benzyl Compounds; Binding, Competitive; Disease Models, Animal; Dose-Response Relationship, Drug; Electroshock; Hot Temperature; Male; Mice; Molecular Structure; Motor Activity; Pain Measurement; Pain Threshold; Pentylenetetrazole; Picrotoxin; Receptors, GABA-A; Receptors, Purinergic P1; Seizures; Structure-Activity Relationship; Urea | 2007 |
Pharmacotherapy for cognitive impairment in a mouse model of Down syndrome.
Topics: Animals; Behavior, Animal; Cognition Disorders; Disease Models, Animal; Down Syndrome; Electric Stimulation; Excitatory Postsynaptic Potentials; Exploratory Behavior; Female; GABA Antagonists; Hippocampus; In Vitro Techniques; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Motor Activity; Neurons; Pentylenetetrazole; Picrotoxin | 2007 |
Anticonvulsant activity of Cotyledon orbiculata L. (Crassulaceae) leaf extract in mice.
Topics: Animals; Anticonvulsants; Bicuculline; Convulsants; Crassulaceae; Dose-Response Relationship, Drug; Male; Mice; N-Methylaspartate; Pentylenetetrazole; Phytotherapy; Picrotoxin; Plant Extracts; Plant Leaves; Seizures | 2007 |
Lacosamide, a novel anti-convulsant drug, shows efficacy with a wide safety margin in rodent models for epilepsy.
Topics: Acetamides; Animals; Anticonvulsants; Bicuculline; Cobalt; Convulsants; Electroshock; Epilepsies, Partial; Epilepsy; Epilepsy, Generalized; Epilepsy, Reflex; Excitatory Amino Acid Agonists; GABA Antagonists; Homocysteine; Kindling, Neurologic; Lacosamide; Male; Mice; N-Methylaspartate; Neurotoxicity Syndromes; Pentylenetetrazole; Picrotoxin; Rats; Rats, Sprague-Dawley; Status Epilepticus | 2007 |
Effects of postnatal caffeine exposure on seizure susceptibility in developing rats.
Topics: Age Factors; Aminophylline; Animals; Animals, Newborn; Behavior, Animal; Bicuculline; Caffeine; Central Nervous System Stimulants; Disease Models, Animal; Disease Susceptibility; Drug Interactions; Pentylenetetrazole; Picrotoxin; Rats; Rats, Wistar; Reaction Time; Seizures; Severity of Illness Index | 2007 |
Drug treatment improves memory in mice.
Topics: Animals; Central Nervous System Stimulants; Chromosomes, Human, Pair 21; Cyclopentanes; Disease Models, Animal; Down Syndrome; Furans; GABA Antagonists; Ginkgolides; Humans; Maze Learning; Memory; Mice; Mice, Transgenic; Neuropsychological Tests; Pentylenetetrazole; Picrotoxin | 2007 |
Anticonvulsant activity of Hypoxis hemerocallidea Fisch. & C. A. Mey. (Hypoxidaceae) corm ('African potato') aqueous extract in mice.
Topics: Animals; Anticonvulsants; Bicuculline; Hypoxis; Male; Mice; Mice, Inbred BALB C; Molecular Structure; Pentylenetetrazole; Phytotherapy; Picrotoxin; Plant Extracts; Seizures | 2008 |
Pro-convulsant effect of cefazolin sodium against pentylenetetrazol- or picrotoxin-induced convulsions in mice.
Topics: Animals; Anti-Bacterial Agents; Behavior, Animal; Cefazolin; Convulsants; GABA-A Receptor Agonists; Male; Mice; Mice, Inbred Strains; Pentylenetetrazole; Picrotoxin; Seizures | 2007 |
Phythochemical screening and anticonvulsant activity of Cymbopogon winterianus Jowitt (Poaceae) leaf essential oil in rodents.
Topics: Animals; Anticonvulsants; Behavior, Animal; Diazepam; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Male; Mice; Oils, Volatile; Pentylenetetrazole; Phenytoin; Phytotherapy; Picrotoxin; Plant Leaves; Plant Oils; Poaceae; Seizures; Strychnine | 2008 |
Effect of classic convulsants on Cl- conductance of the GABA(A) receptor complex in membranes of cerebral cortex cells at the early stage of kindling.
Topics: Animals; Bicuculline; Cerebral Cortex; Chloride Channels; Convulsants; Drug Synergism; GABA-A Receptor Agonists; Kindling, Neurologic; Male; Membranes; Muscimol; Pentylenetetrazole; Picrotoxin; Rats; Rats, Wistar; Receptors, GABA-A; Synaptosomes | 2007 |
Anticonvulsant property of Sutherlandia frutescens R. BR. (variety Incana E. MEY.) [Fabaceae] shoot aqueous extract.
Topics: Analysis of Variance; Animals; Anticonvulsants; Bicuculline; Disease Models, Animal; Dose-Response Relationship, Drug; Fabaceae; Mice; Pentylenetetrazole; Phytotherapy; Picrotoxin; Plant Extracts; Seizures | 2008 |
Sedative and anticonvulsant effects of zolpidem in adult and aged mice.
Topics: Age Factors; Animals; Anticonvulsants; Brain; Convulsants; Diazepam; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Antagonism; Epilepsy; GABA Antagonists; GABA Modulators; gamma-Aminobutyric Acid; Hypnotics and Sedatives; Male; Mice; Mice, Inbred CBA; Motor Activity; Pentylenetetrazole; Picrotoxin; Pyridines; Zolpidem | 2008 |
Anticonvulsant effect of Rhus chirindensis (Baker F.) (Anacardiaceae) stem-bark aqueous extract in mice.
Topics: Animals; Anticonvulsants; Bicuculline; Male; Mice; Mice, Inbred BALB C; Pentylenetetrazole; Picrotoxin; Plant Bark; Plant Extracts; Plant Stems; Rhus | 2008 |
Anticonvulsant characteristics of pyridoxyl-gamma-aminobutyrate, PL-GABA.
Topics: 3-Mercaptopropionic Acid; Animals; Anticonvulsants; Bicuculline; Drug Tolerance; Electrophysiology; Electroshock; Enzyme Inhibitors; Epilepsy; gamma-Aminobutyric Acid; Gerbillinae; Magnesium; Male; Mice; Mice, Inbred BALB C; Neurotoxicity Syndromes; Pentylenetetrazole; Picrotoxin; Pyridoxal Phosphate; Rats; Rats, Sprague-Dawley; Seizures; Tissue Distribution | 2008 |
Seizure termination by acidosis depends on ASIC1a.
Topics: Acid Sensing Ion Channels; Acidosis; Analysis of Variance; Animals; Animals, Newborn; Behavior, Animal; Carbon Dioxide; Electroencephalography; Female; Hippocampus; Hydrogen-Ion Concentration; Interneurons; Kainic Acid; Male; Membrane Potentials; Mice; Mice, Knockout; Nerve Tissue Proteins; Patch-Clamp Techniques; Pentylenetetrazole; Picrotoxin; Seizures; Sodium Channels; Time Factors | 2008 |
Anticonvulsant effect of a natural compound alpha,beta-epoxy-carvone and its action on the nerve excitability.
Topics: Action Potentials; Animals; Anticonvulsants; Convulsants; Cyclohexane Monoterpenes; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Electroshock; Epilepsy; Flumazenil; GABA Modulators; In Vitro Techniques; Male; Mice; Monoterpenes; Pentylenetetrazole; Physical Stimulation; Picrotoxin; Rats; Rats, Wistar; Sciatic Nerve | 2008 |
Comparative pharmacological studies on the analeptic effects of samandarin, picrotoxin and cardiazole.
Topics: Pentylenetetrazole; Picrotoxin | 1948 |
Antiepileptic potential and behavioral profile of L-pGlu-(2-propyl)-L-His-L-ProNH2, a newer thyrotropin-releasing hormone analog.
Topics: Animals; Anticonvulsants; Behavior, Animal; Blood Pressure; Cardiovascular System; Central Nervous System Stimulants; Cerebrovascular Circulation; Convulsants; Electroshock; Hypnotics and Sedatives; Kainic Acid; Male; Mice; Motor Activity; Pentylenetetrazole; Picrotoxin; Rats; Rats, Wistar; Seizures; Sleep; Theophylline; Thyrotropin; Thyrotropin-Releasing Hormone | 2009 |
Anticonvulsant effects of the BK-channel antagonist paxilline.
Topics: Analysis of Variance; Animals; Animals, Newborn; Cell Count; Disease Models, Animal; Dose-Response Relationship, Drug; Electroencephalography; Hippocampus; Indoles; Mice; Mice, Inbred C57BL; Neocortex; Pentylenetetrazole; Picrotoxin; Potassium Channel Blockers; Proto-Oncogene Proteins c-fos; Psychomotor Performance; Seizures; Time Factors | 2009 |
Validation of anticonvulsant and sedative activity of six medicinal plants.
Topics: Animals; Anticonvulsants; Convulsants; Diazepam; Dose-Response Relationship, Drug; Electroshock; Epilepsy; Excitatory Amino Acid Agonists; Hypnotics and Sedatives; Isoniazid; Male; Medicine, African Traditional; Mice; N-Methylaspartate; Pentylenetetrazole; Picrotoxin; Plants, Medicinal; Sleep Initiation and Maintenance Disorders; Stereotyped Behavior; Strychnine | 2009 |
Anticonvulsant activity of Nylandtia spinosa L. Dumont (Polygalaceae) aqueous and methanol leaf extracts in mice.
Topics: Animals; Anticonvulsants; Bicuculline; Convulsants; Epilepsy, Generalized; Lethal Dose 50; Male; Methanol; Mice; N-Methylaspartate; Pentylenetetrazole; Picrotoxin; Plant Extracts; Plant Leaves; Polygalaceae; Seizures; Solvents; Water | 2008 |
Cyclization of the semicarbazone template of aryl semicarbazones: synthesis and anticonvulsant activity of 4,5-diphenyl-2H-1,2,4-triazol-3(4H)-one.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Electroshock; Male; Mice; Pentylenetetrazole; Picrotoxin; Rats; Rats, Sprague-Dawley; Seizures; Semicarbazones; Structure-Activity Relationship; Strychnine; Toxicity Tests | 2009 |
Antiulcer and anticonvulsant activity of Croton zambesicus.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Anticonvulsants; Antipsychotic Agents; Central Nervous System Depressants; Convulsants; Croton; Ethanol; Female; Indomethacin; Male; Medicine, African Traditional; Mice; Nigeria; Pentylenetetrazole; Phenytoin; Picrotoxin; Plant Extracts; Plant Roots; Rats; Reserpine; Stomach Ulcer | 2009 |
Neuropharmacological profile of L-pGlu-(1-benzyl)-L-His-L-ProNH2, a newer thyrotropin-releasing hormone analog: effects on seizure models, sodium current, cerebral blood flow and behavioral parameters.
Topics: Analysis of Variance; Animals; Anticonvulsants; Behavior, Animal; Blood Pressure; Brain; Cerebrovascular Circulation; Dose-Response Relationship, Drug; Electrophysiology; Electroshock; Ganglia, Spinal; Kainic Acid; Male; Mice; Motor Activity; Neurons; Pentylenetetrazole; Picrotoxin; Rats; Rats, Sprague-Dawley; Seizures; Statistics, Nonparametric; Thyrotropin-Releasing Hormone | 2009 |
Effect of Brewer's yeast-induced pyrexia on aminophylline-elicited convulsions in mice.
Topics: Aminophylline; Animals; Anticonvulsants; Apnea; Bronchodilator Agents; Child; Convulsants; Diazepam; Dizocilpine Maleate; Fever; GABA-A Receptor Agonists; GABA-A Receptor Antagonists; GABA-B Receptor Agonists; Humans; Infant; Japan; Male; Mice; Neuroprotective Agents; Pentylenetetrazole; Picrotoxin; Purinergic P1 Receptor Agonists; Saccharomyces cerevisiae; Seizures | 2009 |
Anticonvulsant activity of DNS II fraction in the acute seizure models.
Topics: Acetone; Animals; Anticonvulsants; Delphinium; Diazepam; Epilepsy; Male; Melanoma; Mice; Mice, Inbred Strains; Pakistan; Pentylenetetrazole; Phenytoin; Picrotoxin; Ranunculaceae; Seizures; Skin Neoplasms | 2010 |
Effect of picrotoxin, strychnine and metrazol (pentamethylenetetrazole) on the action of prostigmine and curare on the neuromuscular junction.
Topics: Curare; Muscles; Neostigmine; Neuromuscular Junction; Pentylenetetrazole; Picrotoxin; Strychnine | 1946 |
Modeling seizure-related behavioral and endocrine phenotypes in adult zebrafish.
Topics: Animals; Behavior, Animal; Caffeine; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Female; Hydrocortisone; Locomotion; Male; Numerical Analysis, Computer-Assisted; Pentylenetetrazole; Phenotype; Picrotoxin; Reaction Time; Seizures; Statistics, Nonparametric; Zebrafish | 2010 |
Evaluation of central nervous system effects of iso-6-cassine isolated from Senna spectabilis var. excelsa (Schrad) in mice.
Topics: Animals; Behavior, Animal; Central Nervous System; Dose-Response Relationship, Drug; Ketones; Male; Mice; Motor Activity; Pentylenetetrazole; Phytotherapy; Picrotoxin; Piperidines; Plant Extracts; Plant Leaves; Seizures; Senna Plant | 2011 |
Evaluation of possible antioxidant and anticonvulsant effects of the ethyl acetate fraction from Platonia insignis Mart. (Bacuri) on epilepsy models.
Topics: Acetates; Animals; Anticonvulsants; Antioxidants; Catalase; Corpus Striatum; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Compounding; Drug Interactions; Epilepsy; Gas Chromatography-Mass Spectrometry; Lipid Peroxidation; Male; Manihot; Motor Activity; Muscarinic Agonists; Pentylenetetrazole; Phytotherapy; Picrotoxin; Pilocarpine; Plant Preparations; Random Allocation; Rats; Rats, Wistar; Seizures; Superoxide Dismutase | 2011 |
Characterization of seizures induced by acute and repeated exposure to tetramethylenedisulfotetramine.
Topics: Animals; Astrocytes; Bridged-Ring Compounds; Calcium-Binding Proteins; Cerebral Cortex; Convulsants; Extremities; Glial Fibrillary Acidic Protein; Gliosis; Hippocampus; Male; Mice; Microfilament Proteins; Microglia; Pentylenetetrazole; Picrotoxin; Rats; Rats, Sprague-Dawley; Seizures | 2012 |
UPLC-TOF-MS analysis of Galium spurium towards its neuroprotective and anticonvulsant activities.
Topics: Acetylcholinesterase; Animals; Anticonvulsants; Butyrylcholinesterase; Cholinesterase Inhibitors; Chromatography, Liquid; Disease Models, Animal; Dose-Response Relationship, Drug; Electroshock; Ethanol; Female; Galium; Male; Mice; Motor Activity; Neuroprotective Agents; Pentylenetetrazole; Phytotherapy; Picrotoxin; Plant Components, Aerial; Plant Extracts; Plants, Medicinal; Reaction Time; Seizures; Solvents; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Time Factors | 2012 |
Identification of compounds with anti-convulsant properties in a zebrafish model of epileptic seizures.
Topics: Animals; Anticonvulsants; Central Nervous System; Disease Models, Animal; Drug Evaluation, Preclinical; Embryo, Nonmammalian; Epilepsy; Gene Expression Regulation, Developmental; In Situ Hybridization; Larva; Motor Activity; Muscles; Organ Specificity; Pentylenetetrazole; Picrotoxin; Small Molecule Libraries; Zebrafish | 2012 |
Seizure protection by intrapulmonary delivery of midazolam in mice.
Topics: Animals; Anticonvulsants; Dose-Response Relationship, Drug; Drug Administration Routes; Kainic Acid; Male; Mice; Midazolam; Pentylenetetrazole; Picrotoxin; Seizures | 2013 |
Effects of agomelatine on oxidative stress in the brain of mice after chemically induced seizures.
Topics: Acetamides; Animals; Brain; Catalase; Female; Lipid Peroxidation; Mice; Nitrites; Oxidative Stress; Pentylenetetrazole; Picrotoxin; Pilocarpine; Seizures; Strychnine | 2013 |
Anticonvulsant activity of Hypericum scabrum L.; possible mechanism involved.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Free Radical Scavengers; gamma-Aminobutyric Acid; Hypericum; Male; Medicine, Traditional; Mice; Nitric Oxide; Pentylenetetrazole; Picrotoxin; Plant Extracts; Seizures; Time Factors | 2013 |
Antisense reduction of tau in adult mice protects against seizures.
Topics: Age Factors; Animals; Anticonvulsants; Central Nervous System; Convulsants; Disease Models, Animal; Gait Disorders, Neurologic; Gene Expression Regulation; Infusions, Intraventricular; Lactic Acid; Locomotion; Maze Learning; Mice; Mice, Inbred C57BL; Mice, Knockout; Microdialysis; Oligonucleotides, Antisense; Pentylenetetrazole; Picrotoxin; Seizures; tau Proteins | 2013 |
The analgesic and anticonvulsant effects of piperine in mice.
Topics: Acetic Acid; Alkaloids; Analgesics; Animals; Anticonvulsants; Benzodioxoles; Hot Temperature; Male; Mice; Naloxone; Narcotic Antagonists; Pain; Pentylenetetrazole; Picrotoxin; Piper nigrum; Piperidines; Polyunsaturated Alkamides; Seizures | 2013 |
GABAB, not GABAA receptors play a role in cortical postictal refractoriness.
Topics: Animals; Azepines; Bicuculline; Cerebral Cortex; Electric Stimulation; Electrodes, Implanted; Epilepsy; GABA-A Receptor Antagonists; GABA-B Receptor Antagonists; Male; Organophosphorus Compounds; Pentylenetetrazole; Picrotoxin; Rats, Wistar; Receptors, GABA-A; Receptors, GABA-B | 2015 |
Synthesis, anticonvulsant activity and molecular modeling study of some new hydrazinecarbothioamide, benzenesulfonohydrazide, and phenacylacetohydrazide analogues of 4(3H)-quinazolinone.
Topics: Animals; Anticonvulsants; Dose-Response Relationship, Drug; Hydrazines; Mice; Models, Molecular; Molecular Structure; Pentylenetetrazole; Picrotoxin; Quinazolinones; Seizures; Structure-Activity Relationship; Sulfonamides; Thiourea | 2015 |
Down-regulation of Homer1b/c protects against chemically induced seizures through inhibition of mTOR signaling.
Topics: Animals; Behavior, Animal; Carrier Proteins; Disease Models, Animal; Down-Regulation; Glycine; Hippocampus; Homer Scaffolding Proteins; Maze Learning; Mice; PC12 Cells; Pentylenetetrazole; Phenylacetates; Phosphorylation; Picrotoxin; Rats; Receptor, Metabotropic Glutamate 5; Ribosomal Protein S6 Kinases; RNA Interference; Seizures; Signal Transduction; TOR Serine-Threonine Kinases | 2015 |
Synthesis and Anticonvulsant Activity of N-(Substituted)-1-methyl-2,4-dioxo-1,2-dihydroquinazoline-3(4H)-carboxamides.
Topics: Animals; Anticonvulsants; Dose-Response Relationship, Drug; Electroshock; Methaqualone; Mice; Pentylenetetrazole; Picrotoxin; Quinazolines; Seizures; Structure-Activity Relationship; Valproic Acid | 2016 |
Kappa opioid receptors regulate hippocampal synaptic homeostasis and epileptogenesis.
Topics: Animals; Cells, Cultured; Central Nervous System Stimulants; Convulsants; Disease Models, Animal; Disks Large Homolog 4 Protein; Dose-Response Relationship, Drug; Embryo, Mammalian; Epilepsy; Green Fluorescent Proteins; Hippocampus; Kindling, Neurologic; Male; Mice; Narcotic Antagonists; Narcotics; Neurons; Pentylenetetrazole; Picrotoxin; Rats; Rats, Sprague-Dawley; Receptors, G-Protein-Coupled; Receptors, Opioid, kappa; Repressor Proteins; Synapses; Synaptophysin; Tetrodotoxin; Transfection; Tumor Suppressor Proteins | 2018 |
Susceptibility of larval zebrafish to the seizurogenic activity of GABA type A receptor antagonists.
Topics: Animals; Brain; Bridged-Ring Compounds; Drug Evaluation, Preclinical; GABA-A Receptor Antagonists; Pentylenetetrazole; Picrotoxin; Seizures; Zebrafish | 2020 |
HAP1 Modulates Epileptic Seizures by Regulating GABA
Topics: Adolescent; Adult; Animals; Child; Child, Preschool; Epilepsy, Temporal Lobe; Female; GABA Antagonists; Gene Knockout Techniques; Humans; Inhibitory Postsynaptic Potentials; Male; Nerve Tissue Proteins; Pentylenetetrazole; Picrotoxin; Rats, Sprague-Dawley; Receptors, GABA-A; Up-Regulation; Young Adult | 2020 |
Pharmacological and toxicological effects of Ruta chalepensis L. on experimentally induced seizures and electroencephalographic spectral power in mice.
Topics: Animals; Anticonvulsants; Behavior, Animal; Electroencephalography; Electroshock; Epilepsy; Male; Medicine, Traditional; Mice; Mortality; Pentylenetetrazole; Picrotoxin; Plant Extracts; Ruta; Seizures | 2021 |
Anticonvulsant effects of the aqueous and methanol extracts from the stem bark of Psychotria camptopus Verdc. (Rubiacaea) in rats.
Topics: Animals; Anticonvulsants; Behavior, Animal; Diazepam; Disease Models, Animal; Epilepsy; Methanol; Mice; Pentylenetetrazole; Phytochemicals; Picrotoxin; Plant Bark; Plant Extracts; Plant Stems; Psychotria; Rats, Wistar; Seizures; Semicarbazides; Sleep; Sleep Latency; Strychnine; Water | 2021 |
Probable mechanisms involved in the antiepileptic activity of Clerodendrum polycephalum Baker (Labiatae) leaf extract in mice exposed to chemical-induced seizures.
Topics: Animals; Anticonvulsants; Antioxidants; Arginine; Clerodendrum; Cyclooxygenase 2; Flumazenil; Guanosine Monophosphate; Kainic Acid; Lamiaceae; Methylene Blue; Mice; NF-kappa B; Nitric Oxide; Nitric Oxide Synthase Type I; Pentylenetetrazole; Picrotoxin; Plant Extracts; Receptors, GABA-A; Seizures; Soluble Guanylyl Cyclase; Spasm | 2022 |
Promising anticonvulsant N-[(2,4-dichlorophenyl) methyl]-2-(2,4-dioxo-1H-quinazolin-3-yl) acetamide: dose-dependent study and evaluation of anticonvulsant action spectrum in vivo and in silico.
Topics: Acetamides; Action Spectrum; Animals; Anticonvulsants; Caffeine; gamma-Aminobutyric Acid; Mice; Molecular Docking Simulation; Pentylenetetrazole; Picrotoxin; Seizures; Strychnine | 2022 |
Revealing the most effective anticonvulsant part of Malvaviscus arboreus Dill. Ex Cav. and its acute and sub-acute toxicity.
Topics: Anethum graveolens; Animals; Anticonvulsants; Antioxidants; Epilepsy; Pentylenetetrazole; Picrotoxin; Pilocarpine; Plant Extracts; Seizures; Strychnine; Water | 2023 |