Compounds > picrotoxin
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picrotoxin and 4-butyrolactone

picrotoxin has been researched along with 4-butyrolactone in 16 studies

Research

Studies (16)

TimeframeStudies, this research(%)All Research%
pre-19907 (43.75)18.7374
1990's6 (37.50)18.2507
2000's2 (12.50)29.6817
2010's1 (6.25)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Morgenroth, VH; Nowycky, MC; Roth, RH; Walters, JR1
Eng, N; Pericić, D; Walters, JR1
Canney, DJ; Covey, DF; Ferrendelli, JA; Holland, KD; Levine, JA; McKeon, AC1
Covey, DF; Ferrendelli, JA; Holland, KD; Rothman, SM1
Baker, K; Clifford, DB; Covey, DF; Yang, J; Zorumski, CF2
Covey, DF; Ferrendelli, JA; Levine, JA; Naritoku, DK1
Covey, DF; Ferrendelli, JA; Kalman, BL; Klunk, WE1
Burke, TR; Rice, KC; Skolnick, P; Weissman, BA1
Covey, DF; Rothman, SM; Yoon, KW1
Feigenbaum, JJ; Howard, SG1
Covey, DF; Ferrendelli, JA; Krause, JE; Rothman, SM; Tucker, JB; Weiss, DS; White, G; Williams, KL1
Canney, DJ; Covey, DF; Ferrendelli, JA; Holland, KD; Lu, HF; McKeon, AC; Rothman, SM; Xu, K; Yoon, KW1
Bracamontes, J; Covey, DF; Steinbach, JH; Yu, L; Zhang, P1
Bell-Horner, CL; Chen, ZL; Covey, DF; Das, P; Dillon, GH; Gonzales, EB; Huang, RQ; Raut, A1
Cui, J; Li, ML; Yuan, MS1

Reviews

1 review(s) available for picrotoxin and 4-butyrolactone

ArticleYear
Gamma hydroxybutyrate is not a GABA agonist.
    Progress in neurobiology, 1996, Volume: 50, Issue:1

    Topics: 4-Butyrolactone; Animals; Central Nervous System; Convulsants; Electroencephalography; GABA Agonists; gamma-Aminobutyric Acid; Humans; Mammals; Muscle Contraction; Picrotoxin; Rabbits; Rats; Receptors, GABA; Respiration; Seizures; Sodium Oxybate

1996

Other Studies

15 other study(ies) available for picrotoxin and 4-butyrolactone

ArticleYear
gamma-Hydroxybutyrate: effects on nonstriatal dopaminergic neurons.
    Advances in biochemical psychopharmacology, 1977, Volume: 16

    Topics: 4-Butyrolactone; Animals; Brain; Dihydroxyphenylalanine; Dopamine; Egtazic Acid; Hydroxybutyrates; Kinetics; Neurons; Picrotoxin; Rats; Tyrosine 3-Monooxygenase

1977
Post-mortem and aminooxyacetic acid-induced accumulation of GABA: effect of gamma-butyrolactone and picrotoxin.
    Journal of neurochemistry, 1978, Volume: 30, Issue:4

    Topics: 4-Butyrolactone; Acetates; Aminobutyrates; Aminooxyacetic Acid; Animals; Brain; Chloral Hydrate; Furans; gamma-Aminobutyric Acid; Male; Organ Specificity; Picrotoxin; Postmortem Changes; Rats

1978
Synthesis and structure-activity studies of alkyl-substituted gamma-butyrolactones and gamma-thiobutyrolactones: ligands for the picrotoxin receptor.
    Journal of medicinal chemistry, 1991, Volume: 34, Issue:4

    Topics: 4-Butyrolactone; Alkylation; Animals; Anticonvulsants; Brain; Convulsants; Female; Ligands; Mice; Mice, Inbred Strains; Molecular Structure; Neurotoxins; Picrotoxin; Receptors, GABA-A; Seizures; Structure-Activity Relationship

1991
Physiological regulation of the picrotoxin receptor by gamma-butyrolactones and gamma-thiobutyrolactones in cultured hippocampal neurons.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 1990, Volume: 10, Issue:6

    Topics: 4-Butyrolactone; Animals; Cells, Cultured; Electrophysiology; Furans; gamma-Aminobutyric Acid; Hippocampus; Lactones; Neurons; Picrotoxin; Receptors, Drug; Succinimides

1990
Alpha-substituted thiobutyrolactones potentiate GABA currents in voltage-clamped chick spinal cord neurons.
    Neuroscience letters, 1988, Apr-22, Volume: 87, Issue:1-2

    Topics: 4-Butyrolactone; Animals; Anticonvulsants; Cells, Cultured; Chick Embryo; Diazepam; Furans; gamma-Aminobutyric Acid; Ion Channels; Membrane Potentials; Phenobarbital; Picrotoxin; Spinal Cord

1988
Convulsant gamma-butyrolactones block GABA currents in cultured chick spinal cord neurons.
    Brain research, 1989, Apr-10, Volume: 484, Issue:1-2

    Topics: 4-Butyrolactone; Animals; Cells, Cultured; Chick Embryo; Furans; gamma-Aminobutyric Acid; Membrane Potentials; Picrotoxin; Spinal Cord

1989
Effects of anticonvulsant and convulsant gamma-butyrolactones and thiobutyrolactones on GABA-mediated chloride uptake.
    Biochemical pharmacology, 1987, Mar-15, Volume: 36, Issue:6

    Topics: 4-Butyrolactone; Animals; Anticonvulsants; Cerebral Cortex; Chlorides; Convulsants; Female; Furans; gamma-Aminobutyric Acid; Pentobarbital; Picrotoxin; Rats; Rats, Inbred Strains; Sesterterpenes; Structure-Activity Relationship

1987
Computer-assisted modeling of the picrotoxinin and gamma-butyrolactone receptor site.
    Molecular pharmacology, 1983, Volume: 23, Issue:2

    Topics: 4-Butyrolactone; Chlorides; Computers; Furans; Ion Channels; Models, Chemical; Picrotoxin; Receptors, Cell Surface; Receptors, GABA-A; Sesterterpenes

1983
Alkyl-substituted gamma-butyrolactones inhibit [35S]TBPS binding to a GABA linked chloride ionophore.
    European journal of pharmacology, 1984, Oct-01, Volume: 105, Issue:1-2

    Topics: 4-Butyrolactone; Animals; Barbiturates; Brain; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Bridged-Ring Compounds; Chlorides; Furans; gamma-Aminobutyric Acid; In Vitro Techniques; Ionophores; Male; Membranes; Picrotoxin; Rats; Rats, Inbred Strains

1984
Multiple mechanisms of picrotoxin block of GABA-induced currents in rat hippocampal neurons.
    The Journal of physiology, 1993, Volume: 464

    Topics: 4-Butyrolactone; Animals; Chlorides; Electric Conductivity; gamma-Aminobutyric Acid; Hippocampus; Neurons; Picrotoxin; Rats; Reaction Time

1993
Lactone modulation of the gamma-aminobutyric acid A receptor: evidence for a positive modulatory site.
    Molecular pharmacology, 1997, Volume: 52, Issue:1

    Topics: 4-Butyrolactone; Animals; Chlordiazepoxide; Female; Flumazenil; gamma-Aminobutyric Acid; Lactones; Phenobarbital; Picrotoxin; Receptors, GABA-A; Xenopus laevis

1997
Structure-activity studies of fluoroalkyl-substituted gamma-butyrolactone and gamma-thiobutyrolactone modulators of GABA(A) receptor function.
    Bioorganic & medicinal chemistry, 1998, Volume: 6, Issue:1

    Topics: 4-Butyrolactone; Animals; Anticonvulsants; Binding, Competitive; Bridged Bicyclo Compounds, Heterocyclic; Cells, Cultured; Convulsants; Electrophysiology; Female; Fluorine Compounds; Furans; GABA Modulators; Hippocampus; Mice; Neurons; Picrotoxin; Rats; Receptors, GABA-A; Structure-Activity Relationship

1998
Subunit-specific action of an anticonvulsant thiobutyrolactone on recombinant glycine receptors involves a residue in the M2 membrane-spanning region.
    Molecular pharmacology, 2000, Volume: 58, Issue:1

    Topics: 4-Butyrolactone; Amino Acid Sequence; Amino Acids; Animals; Anticonvulsants; Humans; Membrane Proteins; Molecular Sequence Data; Mutation; Oocytes; Picrotoxin; Rats; Receptors, Glycine; Recombinant Proteins; Sequence Homology, Amino Acid; Sesterterpenes; Transfection; Xenopus

2000
Inhibition of type A GABA receptors by L-type calcium channel blockers.
    Neuroscience, 2004, Volume: 124, Issue:1

    Topics: 4-Butyrolactone; Animals; Benzodiazepines; Binding Sites; Calcium Channel Blockers; Calcium Channels, L-Type; Cell Line; Dihydropyridines; Flumazenil; GABA Modulators; GABA-A Receptor Antagonists; Humans; Hypothalamus; Kidney; Mutagenesis, Site-Directed; Nitrendipine; Picrotoxin; Protein Structure, Tertiary; Rats; Receptors, GABA-A; Recombinant Proteins; Solvents; Species Specificity; Zinc

2004
Semisynthesis of N-acyl homoserinelactone derivatives and the antifeedant activity against Mythimna separata.
    Journal of environmental science and health. Part. B, Pesticides, food contaminants, and agricultural wastes, 2013, Volume: 48, Issue:8

    Topics: 4-Butyrolactone; Acyl-Butyrolactones; Animals; Benzamides; Insecticides; Magnetic Resonance Spectroscopy; Molecular Structure; Moths; Picrotoxin; Sesquiterpenes; Spectrometry, Mass, Electrospray Ionization; Structure-Activity Relationship; Umbelliferones

2013