Page last updated: 2024-09-05

piboserod and gr 113808

piboserod has been researched along with gr 113808 in 25 studies

Compound Research Comparison

Studies (piboserod)	Trials (piboserod)	Recent Studies (post-2010) (piboserod)	Studies (gr 113808)	Trials (gr 113808)	Recent Studies (post-2010) (gr 113808)
119	5	53	165	1	35

Protein Interaction Comparison

Protein	Taxonomy	piboserod (IC50)	gr 113808 (IC50)
5-hydroxytryptamine receptor 4	Homo sapiens (human)		0.0002

Research

Studies (25)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	2 (8.00)	18.2507
2000's	7 (28.00)	29.6817
2010's	16 (64.00)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Bockaert, J; Claeysen, S; Dumuis, A; Faye, P; Lemaire, S; Sebben, M	1
Boulouard, M; Bureau, R; Butt-Gueulle, S; Dauphin, F; Daveu, C; Duchatelle, P; Dumuis, A; Lelong-Boulouard, V; Lemaître, S; Lepailleur, A; Lezoualc'h, F; Pfeiffer, B; Rault, S	1
Andressen, KW; Brudeli, B; Klaveness, J; Krobert, KA; Levy, FO; Moltzau, LR	1
Alisi, MA; Apicella, C; Capezzone de Joannon, A; Cazzolla, N; Costi, R; Cuzzucoli Crucitti, G; Di Santo, R; Furlotti, G; Garrone, B; Iacovo, A; Magarò, G; Mangano, G; Miele, G; Ombrato, R; Pescatori, L; Polenzani, L; Rosi, F; Vitiello, M	1
Andressen, KW; Brudeli, B; Klaveness, J; Levy, FO; Moltzau, LR; Nguyen, CH; Nilsen, NO	1
Andressen, KW; Brudeli, B; Klaveness, J; Levy, FO; Moltzau, LR; Nilsen, NO	1
Andressen, KW; Brudeli, B; Klaveness, J; Levy, FO; Manfra, O; Moltzau, LR; Navaratnarajah, M; Nilsen, NO	1
Bingham, S; Ellis, ES; Gaster, LM; Joiner, GF; King, FD; Sanger, GJ; Sutton, JM; Wardle, KA; Wyman, PA	1
Bécamel, C; Bockaert, J; Claeysen, S; Clark, RD; Dumuis, A; Eglen, RM; Sebben, M	1
Andrade, R; Béïque, JC; Chapin-Penick, EM; Mladenovic, L	1
Fujii, H; Katsui, R; Kojima, Y; Nakagawa, T; Nakajima, Y; Takaki, M	1
Bochet, P; Castro, L; Eschenhagen, T; Fischmeister, R; Guillemeau, A; Lezoualc'h, F; Mialet-Perez, J; Stillitano, F; Zolk, O	1
Cachard-Chastel, M; Croes, S; Deloménie, C; Devijver, H; Dewachter, I; Gardier, AM; Langlois, M; Lezoualc'h, F; Sicsic, S; Van Leuven, F	1
Birkeland, JA; Enger, U; Levy, FO; Lunde, PK; Qvigstad, E; Sejersted, OM; Sjaastad, I; Swift, F; Tovsrud, N	1
Argibay, JA; Bourmeyster, N; Bozon, V; Defamie, N; Derangeon, M; Hervé, JC; Peineau, N; Sarrouilhe, D	1
Hayashi, SS; Kamei, J; Nakanishi, Y; Ohsawa, M	1
Gribovskaja-Rupp, I; Kosinski, L; Ludwig, K; Ridolfi, T; Takahashi, T	1
Amano, T; Ariga, H; Shimizu, K; Uchida, M; Yamato, S	1
Ajjala, DR; Aleti, RR; Bhyrapuneni, G; Kandikere, V; Nirogi, R; Rasheed, MA; Saralaya, R	1
Darcet, F; David, DJ; Gardier, AM; Hen, R; Kerdine-Römer, S; Mendez-David, I; Wu, MV	1
Goshima, H; Ishizuka, T; Ozawa, A; Watanabe, Y	1
De Deurwaerdère, P; Di Giovanni, G; Navailles, S	1
Bertero, A; Caboche, J; Catelani, T; Cavaccini, A; De Luca, MA; Giorgi, A; Gozzi, A; Gritti, M; Heck, N; Locarno, A; Margiani, G; Marotta, R; Mereu, M; Migliarini, S; Pasqualetti, M; Tonini, R; Trusel, M	1
Du, CX; Guo, Y; Liu, J; Lv, SX; Wang, HS; Wang, T; Xie, W; Zhang, J; Zhang, L	1
Agrawal, L; Shiga, T; Vimal, SK	1

Other Studies

25 other study(ies) available for piboserod and gr 113808

Article	Year
Cloning and expression of human 5-HT4S receptors. Effect of receptor density on their coupling to adenylyl cyclase. Neuroreport, 1997, Oct-20, Volume: 8, Issue:15 Topics: Adenylyl Cyclases; Amino Acid Sequence; Animals; Benzamides; Brain Chemistry; Cloning, Molecular; Cyclic AMP; Humans; LLC-PK1 Cells; Membranes; Mice; Molecular Sequence Data; Myocardium; Polymerase Chain Reaction; Radioligand Assay; Rats; Receptors, Serotonin; Species Specificity; Swine	1997
Novel antagonists of serotonin-4 receptors: synthesis and biological evaluation of pyrrolothienopyrazines. Bioorganic & medicinal chemistry, 2009, Mar-15, Volume: 17, Issue:6 Topics: Animals; Chlorocebus aethiops; COS Cells; Humans; Indoles; Models, Molecular; Molecular Structure; Pyrazines; Radioligand Assay; Serotonin 5-HT4 Receptor Antagonists; Serotonin Antagonists; Sulfonamides	2009
Synthesis and pharmacological properties of novel hydrophilic 5-HT4 receptor antagonists. Bioorganic & medicinal chemistry, 2010, Dec-15, Volume: 18, Issue:24 Topics: Amides; Esters; Humans; Indoles; Ligands; Oxazines; Piperidines; Prodrugs; Receptors, Serotonin, 5-HT4; Serotonin 5-HT4 Receptor Antagonists; Structure-Activity Relationship	2010
Discovery and pharmacological profile of new 1H-indazole-3-carboxamide and 2H-pyrrolo[3,4-c]quinoline derivatives as selective serotonin 4 receptor ligands. Journal of medicinal chemistry, 2012, Nov-26, Volume: 55, Issue:22 Topics: Animals; Computational Biology; Dogs; Drug Design; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Humans; Ligands; Macaca fascicularis; Mice; Microsomes, Liver; Molecular Structure; Nociception; Protein Binding; Quinolines; Radioligand Assay; Rats; Receptors, Serotonin, 5-HT4; Structure-Activity Relationship; Swine	2012
Synthesis and pharmacological properties of a new hydrophilic and orally bioavailable 5-HT4 antagonist. European journal of medicinal chemistry, 2013, Volume: 64 Topics: Administration, Oral; Animals; Humans; Hydrophobic and Hydrophilic Interactions; Male; Molecular Structure; Rats; Rats, Sprague-Dawley; Receptors, Serotonin, 5-HT4; Serotonin 5-HT4 Receptor Antagonists; Structure-Activity Relationship	2013
Acidic biphenyl derivatives: synthesis and biological activity of a new series of potent 5-HT(4) receptor antagonists. Bioorganic & medicinal chemistry, 2013, Nov-15, Volume: 21, Issue:22 Topics: Administration, Oral; Animals; Biphenyl Compounds; Caco-2 Cells; Cell Line; Cell Survival; Guinea Pigs; Half-Life; HEK293 Cells; Humans; Male; Mice; Rats; Rats, Sprague-Dawley; Receptors, Serotonin, 5-HT4; Recombinant Proteins; Serotonin 5-HT4 Receptor Agonists	2013
Discovery and pharmacological profile of new hydrophilic 5-HT(4) receptor antagonists. Bioorganic & medicinal chemistry letters, 2014, Sep-15, Volume: 24, Issue:18 Topics: Dose-Response Relationship, Drug; Drug Discovery; Ether-A-Go-Go Potassium Channels; Humans; Hydrophobic and Hydrophilic Interactions; Molecular Structure; Propylene Glycols; Receptors, Serotonin, 5-HT4; Serotonin 5-HT4 Receptor Antagonists; Structure-Activity Relationship	2014
N-[(1-butyl-4-piperidinyl)methyl]-3,4dihydro-2H-[1,3]oxazino[3,2- a]indole10-carboxamide hydrochloride: the first potent and selective 5-HT4 receptor antagonist amide with oral activity. Journal of medicinal chemistry, 1995, Nov-24, Volume: 38, Issue:24 Topics: Administration, Oral; Animals; Dioxanes; Dogs; Guinea Pigs; Indoles; Muscle Contraction; Piperidines; Receptors, Serotonin; Receptors, Serotonin, 5-HT4; Serotonin Antagonists; Structure-Activity Relationship; Sulfonamides	1995
Pharmacological properties of 5-Hydroxytryptamine(4) receptor antagonists on constitutively active wild-type and mutated receptors. Molecular pharmacology, 2000, Volume: 58, Issue:1 Topics: Adenylyl Cyclases; Allosteric Regulation; Aminobenzoates; Animals; COS Cells; Cyclic AMP; Dose-Response Relationship, Drug; GTP-Binding Protein alpha Subunits, Gs; Humans; Indoles; Mice; Models, Biological; Mutation; para-Aminobenzoates; Piperidines; Receptors, Serotonin; Receptors, Serotonin, 5-HT4; Serotonin Antagonists; Sulfonamides; Transfection	2000
Serotonergic facilitation of synaptic activity in the developing rat prefrontal cortex. The Journal of physiology, 2004, May-01, Volume: 556, Issue:Pt 3 Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Amphetamines; Animals; Bicuculline; Fluorobenzenes; GABA-A Receptor Antagonists; Glutamic Acid; Indoles; Lidocaine; Male; Patch-Clamp Techniques; Phenols; Pindolol; Piperidines; Prefrontal Cortex; Pyramidal Cells; Rats; Rats, Sprague-Dawley; Receptor, Serotonin, 5-HT2A; Receptors, AMPA; Receptors, Metabotropic Glutamate; Receptors, Serotonin; Receptors, Serotonin, 5-HT4; Serotonin; Serotonin 5-HT1 Receptor Antagonists; Serotonin 5-HT2 Receptor Antagonists; Serotonin 5-HT4 Receptor Antagonists; Serotonin Antagonists; Sodium Channel Blockers; Sulfonamides; Synapses; Tetrodotoxin; Time Factors	2004
A 5-HT4 agonist, mosapride, enhances intrinsic rectorectal and rectoanal reflexes after removal of extrinsic nerves in guinea pigs. American journal of physiology. Gastrointestinal and liver physiology, 2005, Volume: 289, Issue:2 Topics: Acute Disease; Anal Canal; Animals; Benzamides; Chronic Disease; Denervation; Disease Models, Animal; Gastrointestinal Agents; Gastrointestinal Motility; Guinea Pigs; Indoles; Male; Morpholines; Rectum; Reflex; Serotonin 5-HT4 Receptor Agonists; Serotonin 5-HT4 Receptor Antagonists; Serotonin Antagonists; Spinal Cord Injuries; Sulfonamides	2005
Differential functional effects of two 5-HT4 receptor isoforms in adult cardiomyocytes. Journal of molecular and cellular cardiology, 2005, Volume: 39, Issue:2 Topics: Adenoviridae; Adenylyl Cyclases; Animals; Calcium Channels, L-Type; Humans; Indoles; Isoproterenol; Mice; Myocytes, Cardiac; Pertussis Toxin; Protein Binding; Protein Isoforms; Receptors, Serotonin, 5-HT4; Serotonin 5-HT4 Receptor Antagonists; Sulfonamides	2005
5-HT4 receptor agonists increase sAPPalpha levels in the cortex and hippocampus of male C57BL/6j mice. British journal of pharmacology, 2007, Volume: 150, Issue:7 Topics: Aminobenzoates; Amyloid beta-Protein Precursor; Animals; Benzofurans; Cerebral Cortex; Cholinesterase Inhibitors; Donepezil; Hippocampus; Indans; Indoles; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; para-Aminobenzoates; Piperidines; RNA, Messenger; Serotonin 5-HT4 Receptor Agonists; Serotonin 5-HT4 Receptor Antagonists; Serotonin Antagonists; Serotonin Receptor Agonists; Sulfonamides	2007
Serotonin increases L-type Ca2+ current and SR Ca2+ content through 5-HT4 receptors in failing rat ventricular cardiomyocytes. American journal of physiology. Heart and circulatory physiology, 2007, Volume: 293, Issue:4 Topics: Action Potentials; Adrenergic beta-Agonists; Animals; Calcium Channels, L-Type; Calcium Signaling; Calcium-Binding Proteins; Cardiac Myosins; Cardiotonic Agents; Coronary Vessels; Disease Models, Animal; Heart Failure; Indoles; Isoproterenol; Ketanserin; Ligation; Male; Myocardial Contraction; Myocardial Infarction; Myocytes, Cardiac; Myosin Light Chains; Phosphorylation; Rats; Rats, Wistar; Receptor, Serotonin, 5-HT2A; Receptors, Serotonin, 5-HT4; Sarcoplasmic Reticulum; Serotonin; Serotonin 5-HT2 Receptor Antagonists; Serotonin 5-HT4 Receptor Antagonists; Serotonin Antagonists; Sulfonamides; Time Factors; Troponin I; Ventricular Function	2007
5-HT4 and 5-HT2 receptors antagonistically influence gap junctional coupling between rat auricular myocytes. Journal of molecular and cellular cardiology, 2010, Volume: 48, Issue:1 Topics: Adenylyl Cyclases; Aminobenzoates; Animals; Animals, Newborn; Blotting, Western; Cells, Cultured; Connexins; Gap Junctions; Heart Atria; In Vitro Techniques; Indoles; Myocytes, Cardiac; para-Aminobenzoates; Patch-Clamp Techniques; Phosphorylation; Piperidines; Rats; Rats, Wistar; Receptor, Serotonin, 5-HT2A; Receptor, Serotonin, 5-HT2B; Receptor, Serotonin, 5-HT2C; Receptors, Serotonin, 5-HT4; Reverse Transcriptase Polymerase Chain Reaction; Serotonin; Serotonin 5-HT2 Receptor Antagonists; Serotonin 5-HT4 Receptor Antagonists; Serotonin Agents; Serotonin Antagonists; Sulfonamides	2010
Effect of chronic pain on morphine-induced respiratory depression in mice. Neuroscience, 2011, Feb-03, Volume: 174 Topics: Analgesics, Opioid; Animals; Benzamides; Brain Stem; Chronic Disease; Indoles; Ligation; Male; Mice; Mice, Inbred ICR; Morphine; Morpholines; Pain; Peripheral Nervous System Diseases; Receptors, Serotonin, 5-HT4; Respiration; Respiratory Insufficiency; Sciatic Nerve; Serotonin 5-HT4 Receptor Agonists; Serotonin 5-HT4 Receptor Antagonists; Sulfonamides	2011
Upregulation of mucosal 5-HT3 receptors is involved in restoration of colonic transit after pelvic nerve transection. Neurogastroenterology and motility, 2012, Volume: 24, Issue:5 Topics: Animals; Blotting, Western; Chromium Radioisotopes; Colon; Denervation; Dose-Response Relationship, Drug; Enteric Nervous System; Gastrointestinal Transit; In Vitro Techniques; Indoles; Intestinal Mucosa; Male; Ondansetron; Pelvis; Peripheral Nerves; Rats; Rats, Sprague-Dawley; Receptors, Serotonin, 5-HT3; Receptors, Serotonin, 5-HT4; Serotonin 5-HT3 Receptor Antagonists; Serotonin 5-HT4 Receptor Antagonists; Serotonin Antagonists; Sulfonamides; Up-Regulation	2012
Dual role of mosapride citrate hydrate on the gastric emptying evaluated by the breath test in conscious rats. Journal of pharmacological sciences, 2013, Volume: 121, Issue:4 Topics: Acetic Acid; Animals; Benzamides; Breath Tests; Carbon Radioisotopes; Depression, Chemical; Dose-Response Relationship, Drug; Gastric Emptying; Indoles; Male; Morpholines; Radiopharmaceuticals; Rats; Rats, Sprague-Dawley; Receptor, Muscarinic M1; Serotonin 5-HT3 Receptor Antagonists; Serotonin 5-HT4 Receptor Agonists; Serotonin 5-HT4 Receptor Antagonists; Stimulation, Chemical; Sulfonamides	2013
In-vivo rat striatal 5-HT4 receptor occupancy using non-radiolabelled SB207145. The Journal of pharmacy and pharmacology, 2013, Volume: 65, Issue:5 Topics: Aniline Compounds; Animals; Benzofurans; Binding, Competitive; Brain; Drug Discovery; Indoles; Ligands; Male; Oxazines; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, Serotonin, 5-HT4; Serotonin Receptor Agonists; Sulfonamides; Tandem Mass Spectrometry; Tissue Distribution	2013
Rapid anxiolytic effects of a 5-HT₄ receptor agonist are mediated by a neurogenesis-independent mechanism. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2014, Volume: 39, Issue:6 Topics: Aniline Compounds; Animals; Anti-Anxiety Agents; Antidepressive Agents, Second-Generation; Anxiety; Comorbidity; Corticosterone; Depressive Disorder; Disease Models, Animal; Fluoxetine; Hippocampus; Indoles; Male; Mice; Mice, Inbred C57BL; Neurogenesis; Neurons; Piperidines; Receptors, Serotonin, 5-HT4; Serotonin 5-HT4 Receptor Agonists; Serotonin 5-HT4 Receptor Antagonists; Sulfonamides; Time Factors	2014
Stimulation of 5-HT4 receptor enhances differentiation of mouse induced pluripotent stem cells into neural progenitor cells. Clinical and experimental pharmacology & physiology, 2014, Volume: 41, Issue:5 Topics: Animals; Cell Culture Techniques; Cell Differentiation; Cell Line; CREB-Binding Protein; Cyclic AMP-Dependent Protein Kinases; Indoles; Induced Pluripotent Stem Cells; Mice; Microscopy, Fluorescence; Neural Stem Cells; Phosphorylation; Protein Kinase Inhibitors; Receptors, Serotonin, 5-HT4; Serotonin; Serotonin 5-HT4 Receptor Agonists; Serotonin 5-HT4 Receptor Antagonists; Sulfonamides	2014
The 5-HT4 Agonist Prucalopride Stimulates L-DOPA-Induced Dopamine Release in Restricted Brain Regions of the Hemiparkinsonian Rat In Vivo. CNS neuroscience & therapeutics, 2015, Volume: 21, Issue:9 Topics: Animals; Benzofurans; Brain; Dopamine; Dopamine Agents; Functional Laterality; Indoles; Levodopa; Microdialysis; Oxidopamine; Parkinsonian Disorders; Rats; Serotonin 5-HT4 Receptor Agonists; Serotonin 5-HT4 Receptor Antagonists; Sulfonamides	2015
Serotonergic Signaling Controls Input-Specific Synaptic Plasticity at Striatal Circuits. Neuron, 2018, 05-16, Volume: 98, Issue:4 Topics: Animals; Calcium Signaling; Corpus Striatum; Excitatory Postsynaptic Potentials; Indoles; Large-Conductance Calcium-Activated Potassium Channels; Long-Term Synaptic Depression; Mice; Mice, Transgenic; Neural Pathways; Neuronal Plasticity; Optogenetics; Piperidines; Propane; Receptors, Serotonin, 5-HT4; Serotonin; Serotonin 5-HT4 Receptor Antagonists; Sulfonamides; Synapses; Thalamus	2018
Activation and blockade of serotonin Neurological research, 2019, Volume: 41, Issue:7 Topics: Animals; Benzimidazoles; Brain; Bridged Bicyclo Compounds, Heterocyclic; Dopamine; Dose-Response Relationship, Drug; Habenula; Indoles; Male; Maze Learning; Memory, Short-Term; Microinjections; Norepinephrine; Oxidopamine; Parkinsonian Disorders; Rats; Receptors, Serotonin, 5-HT4; Serotonin; Serotonin 5-HT4 Receptor Agonists; Serotonin 5-HT4 Receptor Antagonists; Substantia Nigra; Sulfonamides	2019
Role of serotonin 4 receptor in the growth of hippocampal neurons during the embryonic development in mice. Neuropharmacology, 2019, 11-01, Volume: 158 Topics: Aniline Compounds; Animals; Axons; Brain-Derived Neurotrophic Factor; Dendrites; Embryo, Mammalian; Gene Knockdown Techniques; Hippocampus; Indoles; Intercellular Signaling Peptides and Proteins; Mice; Nerve Growth Factor; Nerve Growth Factors; Nerve Tissue Proteins; Neurogenesis; Neurons; Piperidines; Receptors, Serotonin, 5-HT4; RNA, Messenger; Serotonin 5-HT4 Receptor Agonists; Serotonin 5-HT4 Receptor Antagonists; Sulfonamides	2019