phytosphingosine has been researched along with sphingosine in 238 studies
| Studies (phytosphingosine) | Trials (phytosphingosine) | Recent Studies (post-2010) (phytosphingosine) | Studies (sphingosine) | Trials (sphingosine) | Recent Studies (post-2010) (sphingosine) |
|---|---|---|---|---|---|
| 256 | 3 | 112 | 8,325 | 117 | 3,459 |
| Protein | Taxonomy | phytosphingosine (IC50) | sphingosine (IC50) |
|---|---|---|---|
| ubiquitin-conjugating enzyme E2 N | Homo sapiens (human) | 6.3125 | |
| cAMP-dependent protein kinase catalytic subunit alpha | Rattus norvegicus (Norway rat) | 0.098 | |
| Sphingosine kinase 2 | Homo sapiens (human) | 1.56 | |
| Sphingosine kinase 1 | Homo sapiens (human) | 3.86 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 13 (5.46) | 18.7374 |
| 1990's | 20 (8.40) | 18.2507 |
| 2000's | 89 (37.39) | 29.6817 |
| 2010's | 90 (37.82) | 24.3611 |
| 2020's | 26 (10.92) | 2.80 |
| Authors | Studies |
|---|---|
| Don, AS; Martinez-Lamenca, C; Proia, RL; Roberts, E; Rosen, H; Webb, WR | 1 |
| Caines, ME; Hancock, SM; Rich, JR; Strynadka, NC; Withers, SG | 1 |
| Costello, C; Iwamori, M; Moser, HW | 1 |
| Crossman, MW; Hirschberg, CB | 2 |
| Dearborn, DG; Korn, ED; Smith, S | 1 |
| Nagel, GW; Turinsky, J | 1 |
| Dickson, RC; Lester, RL; Patton, JL; Srinivasan, B | 1 |
| Takamatsu, K | 1 |
| Dickson, RC; Lester, RL; Pinto, WJ; Schmidt, A; Shepherd, S; Srinivasan, B | 1 |
| Lester, RL; Pinto, WJ; Wells, GW | 1 |
| Dabrowski, J; Dabrowski, U; Egge, H; Peter-Katalinić, J; Röder, B; Sandhoff, K; Schwarzmann, G | 1 |
| Jamison, WC; Liotta, DC; Merrill, AH; Mullins, RE; Nimkar, S; Wang, E | 1 |
| Bornet, H; Bouchon, B; Orgiazzi, J; Portoukalian, J | 1 |
| Nishimura, K | 1 |
| Bouhours, D; Bouhours, JF | 2 |
| Radin, NS | 1 |
| Ariga, T; DeGasperi, R; Hirabayashi, Y; Koerner, TA; Li, SC; Li, YT; Yu, RK | 1 |
| Dell, A; Inoue, S; Inoue, Y; Khoo, KH; Kitajima, K; Morris, HR; Song, Y | 1 |
| Downing, DT; Stewart, ME | 1 |
| Evans, JE; Gross, SK; Lyerla, TA; McCluer, RH | 1 |
| Bernaud, F; Flamand, N; Gaetani, Q; Justine, P; Rougier, A | 1 |
| Beeler, T; Dunn, T; Zhao, C | 1 |
| Carman, GM; Lin, YP; Merrill, AH; Wang, E; Wu, WI | 1 |
| Baltisberger, JA; Dickson, RC; Lester, RL; Nagiec, EE; Nagiec, MM; Wells, GB | 1 |
| Baltisberger, JA; Dickson, RC; Lester, RL; Nagiec, MM; Qie, L | 1 |
| Huhtaniemi, I; Kinnunen, PK; Lauraeus, S; Paukku, T | 1 |
| Dickson, RC; Lester, RL; Nagiec, MM; Skrzypek, MS | 1 |
| Lanterman, MM; Saba, JD | 1 |
| Bodennec, J; Brichon, G; Koul, O; Portoukalian, J; Zwingelstein, G | 2 |
| Marić, V; Mesarić, M; Rupcić, J | 1 |
| Bauer, BL; Bertalanffy, H; Geyer, R; Gschwind, RM; Jennemann, R; Selmer, T; Wiegandt, H | 1 |
| Grilley, MM; Takemoto, JY | 1 |
| Chung, N; Obeid, LM | 1 |
| Li, S; Needleman, DH; Schroepfer, GJ; Sharma, C; Smith, T | 1 |
| Bodennec, J; Brichon, G; Famy, C; Portoukalian, J; Zwingelstein, G | 1 |
| Chung, N; Hannun, YA; Heitman, J; Jenkins, G; Obeid, LM | 1 |
| Azuma, H; Ogino, K; Tamagaki, S | 1 |
| Friant, S; Funato, K; Riezman, H; Stevenson, BJ; Sütterlin, C; Zanolari, B | 1 |
| Bielawska, A; Mao, C; Obeid, LM; Szulc, ZM; Xu, R | 1 |
| Caligan, TB; Merrill, AH; Ou, J; Peters, K; Wang, E | 1 |
| Carman, GM; Wu, WI | 1 |
| Bittman, R; Byun, HS; He, L | 1 |
| Alcantara, K; Ardail, D; Louisot, P; Pons, A; Popa, I; Portoukalian, J; Thomas, L; Zanetta, JP | 1 |
| Franke, S; Heinz, E; Moll, H; Sperling, P; Ternes, P; Zähringer, U | 1 |
| Abe, M; Minemura, M; Nishida, I; Ohya, Y; Qadota, H; Seyama, Y; Watanabe, T | 1 |
| Chuard, R; Conzelmann, A; Guillas, I; Jazwinski, SM; Jiang, JC; Kirchman, PA; Pfefferli, M | 1 |
| Cho, NJ; Lee, JS; Min, DS; Park, C; Park, CS | 1 |
| Chung, N; Hannun, YA; Heitman, J; Mao, C; Obeid, LM | 1 |
| Heise, N; Jones, C; Lopes-Bezerra, LM; Loureiro y Penha, CV; Mattos, KA; Mendonça-Previato, L; Previato, JO; Todeschini, AR; Wait, R | 1 |
| Friant, S; Hall, MN; Lombardi, R; Riezman, H; Schmelzle, T | 1 |
| Levery, SB; Straus, AH; Takahashi, HK; Toledo, MS | 1 |
| Alsén, B; Angström, J; Bäckhed, F; Breimer, ME; Richter-Dahlfors, A; Roche, N; Teneberg, S; von Euler, A; Westerlund-Wikström, B | 1 |
| Bauman, M; Marić, V; Mesarić, M; Ribar, S | 1 |
| Germann, M; Liu, Y; McDonough, V; Nickels, JT; Stukey, J; Sturley, SL; Swain, E | 1 |
| Barreto-Bergter, E; Maciel, DM; Rodrigues, ML; Tischer, CA; Villas Boas, MH; Wait, R | 1 |
| Haustein, UF; Nenoff, P | 1 |
| Lee, GH; Lee, MH; Yoo, JS | 1 |
| Cheng, J; Chio, LC; Fischl, AS; Park, TS; Ye, XS | 1 |
| Bae, S; Cho, CK; Choi, JA; Choi, WI; Chung, HY; Kang, CM; Kang, JA; Kang, S; Kim, S; Kim, TH; Lee, SJ; Lee, YS; Park, MT | 1 |
| Lankhorst, P; Ponec, M; Weerheim, A; Wertz, P | 1 |
| Lynch, DV; O'Brien, TC; Snow, JW; Wright, BS | 1 |
| Chiu, HY; Lin, CC; Patkar, LN; Tzou, DL | 1 |
| Fukuda, Y; Igarashi, Y; Kihara, A | 1 |
| KATES, M; SASTRY, PS | 1 |
| WEISS, B | 1 |
| Bae, S; Cho, CK; Choi, JA; Chung, HY; Kang, CM; Kang, S; Kim, MJ; Lee, SJ; Lee, YS; Park, MT; Um, HD | 1 |
| Merrill, AH; Peng, Q; Sullards, MC; Wang, E | 1 |
| Kim, HJ; Kim, HO; Kim, TY; Park, CS; Shin, W | 1 |
| Kim, HJ; Kim, SH; Kim, TY | 1 |
| Deguchi, H; Griffin, JH; Yegneswaran, S | 1 |
| Kim, HJ; Kim, SH; Kim, TY; Lim, SC | 1 |
| Aoki, K; Hada, N; Itonori, S; Katayama, T; Kumagai, H; Sugita, M; Takeda, T; Uchiyama, R; Yamada-Hada, J; Yamamoto, K; Yamauchi, S | 1 |
| Goetschy, JF; Movva, NR; Roth, LW; Welsch, CA | 1 |
| Kang, SY; Kim, HJ; Kim, SH; Kim, SJ; Kim, TY | 1 |
| Korevaar, CG; Overkleeft, HS; van Boom, JH; van den Berg, RJ; van der Marel, GA | 1 |
| Bouwstra, J; de Jager, M; Gooris, G; Ponec, M | 1 |
| Bae, S; Cho, CK; Choi, JA; Choi, SY; Chung, HY; Kang, CM; Kang, S; Kang, YH; Kim, MJ; Lee, JH; Lee, SJ; Lee, YS; Park, MT | 1 |
| Neubert, RH; Raudenkolb, S; Wartewig, S | 1 |
| Ikekita, M; Kaneko, N; Kuroda, S; Nagahara, Y; Nishio, R; Shinomiya, T | 1 |
| Mendelsohn, R; Moore, DJ; Rerek, ME; Van Wyck, D | 1 |
| Dickson, RC; Lester, RL; Liu, K; Zhang, X | 1 |
| Borchert, HH; Yilmaz, E | 2 |
| Igarashi, Y; Iwaki, S; Kihara, A; Kurotsu, F; Sano, T | 1 |
| Baek, SW; Cho, MH; Jin, HJ; Kim, CK; Kim, JS; Kim, NK; Koh, CW; Kwon, OH; Park, CK | 1 |
| Funari, SS; Garamus, VM; Kiselev, MA; Neubert, R; Wartewig, S; Zbytovská, J | 1 |
| Dickson, RC; Lester, RL; Liu, K; Sumanasekera, C; Zhang, X | 1 |
| Coddeville, B; Delplace, F; Jouault, T; Maes, E; Mille, C; Poulain, D; Strecker, G; Trinel, PA; Zanetta, JP | 1 |
| Moye-Rowley, WS; Panwar, SL | 1 |
| Boltje, TJ; Litjens, RE; Overkleeft, HS; van den Berg, RJ; van der Marel, GA; Verhagen, CP | 1 |
| Bundle, DR; Cai, Y; Ling, CC | 2 |
| Aoyama, T; Ehara, T; Hara, A; Hu, R; Kannagi, R; Kyogashima, M; Li, G; Tamiya-Koizumi, K | 1 |
| Capdevila, MG; Lombardo, M; Pasi, F; Trombini, C | 1 |
| Greenwood, MT; Jean-Baptiste, G; Khoury, C; Yang, Z | 1 |
| Im, DS; Im, YJ; Kim, YL; Lee, YK | 1 |
| Kim, D; Kim, S; Ko, H; Lee, S; Lee, T | 1 |
| Choi, SY; Chung, HY; Jang, YJ; Kim, MJ; Lee, SJ | 1 |
| Chung, HY; Kang, YH; Kim, CH; Lee, SJ; Lee, YS; Park, IC; Park, MT | 1 |
| Kim, D; Kim, S; Kwak, YS; Lee, S; Lee, T | 1 |
| Ha, HJ; Kim, Y; Kim, YW; Lee, BK; Lee, WK; Yoon, HJ | 1 |
| Cowart, LA; Hannun, YA | 1 |
| Kim, BJ; Kim, CD; Kim, MY; Kwon, YB; Lee, JH; Park, CS; Park, JK; Seo, YJ; Suhr, KB; Yoon, TJ | 1 |
| Bao, D; Calvo, AM; Harris, SD; Li, S; Yuen, G | 1 |
| Akabane, M; Annoura, H; Imajo, S; Miyake, S; Murata, K; Nakanishi, K; Nakatsuka, T; Takahashi, B; Takemoto, N; Toba, T; Yamamura, T | 1 |
| Delhaize, E; Dong, B; Franke, S; Liu, Q; Ryan, PR; Sperling, P | 1 |
| An, GI; Cheon, GJ; Chi, DY; Kim, SW; Lee, KC; Lee, SJ; Moon, BS; Park, JH; Park, MT; Yang, SD | 1 |
| Bielawski, J; Dong, H; Hanada, K; Hannun, YA; Mu, J; Shi, L; Teng, C; Tomishige, N; Yang, X; Zhang, J; Zuo, J | 1 |
| Kim, S; Lee, N; Lee, S; Lee, T; Lee, YM | 1 |
| Amemiya, F; Enomoto, N; Inoue, T; Itakura, J; Itakura, Y; Itoh, M; Kanayama, A; Kitamura, T; Maekawa, S; Matsui, A; Okada, S; Sakamoto, M; Sakamoto, N; Takano, S; Yamaguchi, T; Yamashita, A; Yamauchi, K | 1 |
| Chang, YT; Chung, SK; Diaz, K; Lee, JH; Li, Q; Park, JJ | 1 |
| Castro, A; Falcão, A; Glass, NL; Lemos, C; Videira, A | 1 |
| Cammue, BP; Chow, KK; François, IE; Hillaert, U; Meert, EM; Thevissen, K; Van Calenbergh, S | 1 |
| Affolter, VK; Hilton, H; White, SD | 1 |
| Canals, D; Casas, J; Delgado, A; Fabriàs, G; Llebaria, A; Mormeneo, D | 1 |
| Hoeller, S; Sperger, A; Valenta, C | 1 |
| Elsner, P; Falcicchio, A; Jensen, KL; Jiang, H; Jørgensen, KA; Marcos, V | 1 |
| Castro, A; Glass, NL; Kasuga, T; Lemos, C; Tian, C; Videira, A | 1 |
| Chen, W; Hang, W; Huang, B; Lin, L; Song, X; Yan, L; Yan, X; Zhang, J | 1 |
| Hasanovic, A; Hoeller, S; Valenta, C | 1 |
| Luis, CS; Mueller, RS; Stroh, A; Werckenthin, C | 1 |
| Amerongen, AV; Nazmi, K; Valentijn-Benz, M; van Marle, J; van't Hof, W; Veerman, EC | 1 |
| Cho, HJ; Chun, KH; Kong, SY; Lee, JS; Moon, KJ; Park, S; Park, SR; Yoon, SS | 1 |
| Aerts, AM; Cammue, BP; Carmona-Gutierrez, D; François, IE; Hannun, YA; Idkowiak-Baldys, J; Klionsky, DJ; Madeo, F; Thevissen, K; Yen, WL | 1 |
| Klang, V; Matsko, N; Valenta, C; Vojnikovic, E; Zimmermann, AM | 1 |
| Choi, YJ; Hong, SH; Joe, YA; Kim, BM; Lee, YH | 1 |
| Bittman, R; Byun, HS; Liu, Z | 1 |
| Kim, DH; Lee, B; Lee, IA; Oh, S; Ryu, KR | 1 |
| Mueller, MJ; Peer, M; Stegmann, M; Waller, F | 1 |
| Choi, GH; Kim, YY; Wahid, F | 1 |
| Brice, SE; Cowart, LA; Hanson, PK; Johnson, SS; Manoharlal, R; Moye-Rowley, WS | 1 |
| Dubey, A; Kumar, P; Puranik, VG | 1 |
| Andrieu-Abadie, N; Génisson, Y; Ladeira, S; Levade, T; Rives, A | 1 |
| Baek, DJ; Kim, D; Kim, S; Lee, S; Lee, YM | 1 |
| Hinder, A; Neubert, RH; Rawlings, AV; Schmelzer, CE | 1 |
| Baudouin, E; Guillas, I; Zachowski, A | 1 |
| Riley, RT; Zitomer, NC | 1 |
| Gonda, J; Kožíšek, J; Kuchár, J; Martinková, M; Pomikalová, K | 1 |
| Ideta, R; Nakano, Y; Sakuta, T; Uchiyama, T | 1 |
| Igarashi, Y; Kobayashi, N; Kurihara, T; Mitsutake, S; Mizutani, Y; Murakami, I; Shigyo, T; Wakasa, Y; Yamashita, S; Zama, K | 1 |
| Lee, WS | 1 |
| Andrieu-Abadie, N; Baudoin-Dehoux, C; Génisson, Y; Rives, A; Saffon, N | 1 |
| Blanchette, DR; Brogden, KA; Dawson, DV; Drake, DR; Fischer, CL; Wertz, PW | 1 |
| Byun, HJ; Cho, KH; Chung, JH; Eun, HC; Lee, MJ; Lee, S; Lee, Y | 1 |
| Chang, Y; Lu, X; Wu, Z; Xu, G; Zhao, C; Zhao, Y; Zhou, J; Zhu, Z | 1 |
| Chen, L; Chen, YH; Hu, ZM; Li, JL; Li, SF; Song, LY; Wang, RR; Yin, WB | 1 |
| Bink, A; Cammue, BP; Coenye, T; Govaert, G; Nelis, HJ; Thevissen, K; Vandenbosch, D | 1 |
| Baspinar, Y; Borchert, HH | 1 |
| Brière, C; Cotelle, V; Da Silva, D; Grat, S; Lachaud, C; Mazars, C; Prigent, E; Thuleau, P | 1 |
| Ramu Sridhar, P; Seshadri, K; Suresh, M; Venkata Rao, C; Venu Kumar, P | 1 |
| Jaikishan, S; Slotte, JP | 1 |
| Blanchette, DR; Brogden, KA; Dawson, DV; Drake, DR; Fischer, CL; Walters, KS; Wertz, PW | 1 |
| Igarashi, Y; Kobayashi, N; Matsuda, J; Mitsutake, S; Murakami, I; Shigyo, T; Suzuki, A | 1 |
| Lopes, LB; McCall, M; Pepe, D; Zheng, H | 1 |
| Brown, NA; Colabardini, AC; Goldman, GH; Goldman, MH; Savoldi, M | 1 |
| Karaś, MA; Russa, R | 1 |
| Cichewicz, A; Connors, A; Hass, MA; Lopes, LB; Pacleb, C | 1 |
| Calder, ED; Sutherland, A; Zaed, AM | 1 |
| Moye-Rowley, WS; Paul, S | 1 |
| Farwick, M; Koehler, T; Liebisch, G; Paragh, G; Schmitz, G; Sigruener, A; Tarabin, V | 1 |
| Jung, YG; Kim, BH; Kim, S; Kim, TY; Lee, JM | 1 |
| Accardo, S; Bielawski, J; Cammue, B; De Snijder, P; De Vos, D; Ghillebert, R; Hannun, YA; Idkowiak-Baldys, J; Smets, B; Swinnen, E; Thevissen, K; Wilms, T; Winderickx, J | 1 |
| Iba, A; Morita, M; Nagahara, Y; Nakata, T; Shinomiya, T | 1 |
| Di Benedetto, R; Di Brisco, R; Panza, L; Rajabi, M; Varese, M; Zanetti, L | 1 |
| Farwick, M; Felsner, I; Grether-Beck, S; Koehler, T; Krutmann, J; Lersch, P; Rawlings, AV | 1 |
| Anglada, JM; Crehuet, R; Delgado, A; Mormeneo, D | 1 |
| Arnebrant, T; Bikker, FJ; Brand, HS; Lindh, L; Nazmi, K; Sotres, J; Valentijn-Benz, M; van 't Hof, W; Veerman, EC | 1 |
| Guo, JR; Liao, CC; Tsai, YF; Wu, YF; Yu, CP; Yu, HM | 1 |
| Kihara, A; Kitamura, T; Kondo, N; Naganuma, T; Obara, T; Ohno, Y; Seki, N; Yamagata, M | 1 |
| Boonen, J; De Spiegeleer, B; Guillaume, J; Risseeuw, M; Roche, N; Shah, SN; Taevernier, L; Van Calenbergh, S; Veryser, L | 1 |
| Bae, YS; Bhattarai, D; Chung, G; Han, SH; Her, Y; Hwang, S; Jin, G; Kim, J; Lee, K; Park, S; Seong, I | 1 |
| Arnebrant, T; Bikker, FJ; Brand, HS; Cukkemane, N; Lindh, L; Nazmi, K; Sotres, J; Veerman, EC | 1 |
| Kannagi, R; Kyogashima, M; Murate, T; Tamiya-Koizumi, K; Tanaka, K; Yamada, M | 1 |
| Cordeiro, AM; de Almeida, RF; Herrmann, A; Marinho, HS; Marquês, JT; Viana, AS | 1 |
| Avilés, M; Bernabeu, R; García, EM; Gil-Izquierdo, Á; Gómez-Torres, MJ; González-Brusi, L; Guerrero, J; Izquierdo-Rico, MJ; Medina, S; Orduna, J; Savirón, M; Ten, J | 1 |
| Cahoon, EB; Luttgeharm, KD; Markham, JE | 1 |
| Dobner, B; Huster, D; Lange, S; Stahlberg, S | 1 |
| Gao, H; Li, C; Qi, G; Yin, R; Zhang, H; Zhao, X | 1 |
| Bikker, FJ; Çetiner, S; Kleverlaan, CJ; Lagerweij, MD; Özen, B; van Loveren, C; van Strijp, AJ; Yönel, N | 1 |
| Hsu, FF | 1 |
| Hsu, FF; Lone, MA; Martínez-Montañés, F; Schneiter, R | 1 |
| Dobner, B; Lange, S; Langner, A; Neubert, RH; Sonnenberger, S | 1 |
| Fischer, C; Fischer, M; Hünniger, T; Klockmann, S; Paschke-Kratzin, A; Schrader, J; Wessels, H | 1 |
| Cowart, LA; Greenberg, ML; Jadhav, S; Russo, S | 1 |
| Kováčik, A; Opálka, L; Školová, B; Tesař, O; Vávrová, K | 1 |
| Kihara, A; Kitamura, T; Seki, N | 1 |
| Cubells-Baeza, N; Díaz-Perales, A; Garrido-Arandia, M; Gómez-Casado, C; González-Melendi, P; Herrero, M; Pacios, LF; Ramírez-Castillejo, C; Tordesillas, L | 1 |
| Dong, X; Meng, P; Qin, W; Tan, G; Wang, H; Wu, H; Yuan, J | 1 |
| Hong, JY; Jang, EJ; Jung, C; Kim, D; Kim, S; Lee, SK; Park, HJ; Shin, Y | 1 |
| Han, L; Jia, RX; Sun, LW; Wan, YJ; Wang, F; Yang, H; Zhang, GM; Zhang, YL | 1 |
| Cho, YH; Choi, HK; Kim, JW; Lee, EO; Park, CS | 1 |
| Bikker, FJ; Hoogenkamp, MA; Krom, BP; Malhaoui, A; Nazmi, K; Neilands, J | 1 |
| Hama, Y; Higashiyama, S; Igarashi, Y; Mitsutake, S; Nagasawa, T; Nakamichi, H | 1 |
| Chen, IC; Luo, SY; Sankar, A | 1 |
| Kawakami, K; Nagahara, Y; Nishikawa, R; Shinomiya, T; Sikandan, A; Yagi, D | 1 |
| Chen, X; Ghosh, T; Li, Y; McArthur, JB; Santra, A; Wang, PG; Yang, X; Yu, H | 1 |
| Deng, J; Guo, Y; Song, J; Sun, Z; Wang, A; Wang, X; Xu, K; Yang, Y; Zhang, X | 1 |
| Demé, B; Dobner, B; Lange, S; Langner, A; Neubert, RHH; Schmitt, T; Sonnenberger, S | 1 |
| Gonda, J; Jáger, D; Kupka, D; Martinková, M; Pilátová, MB; Raschmanová, JŠ | 1 |
| Jia, H; Liu, Y; Ma, L; Sun, L; Yang, Y; Yu, M; Zhang, H; Zou, Z | 1 |
| Edinger, AL; Garsi, JB; Hanessian, S; McCracken, AN; Sernissi, L; Simitian, G; Vece, V | 1 |
| Choi, HK; Kim, HJ; Liu, KH; Park, CS | 1 |
| Compostella, F; Imperio, D; Panza, L | 1 |
| Kihara, A; Kitamura, T; Miyamoto, M; Mori, K; Seki, N | 1 |
| Ando, T; Isobe, M; Izawa, K; Kaitani, A; Kinjo, Y; Kitamura, T; Kitaura, J; Maehara, A; Matsukawa, T; Nagamine, M; Ogawa, H; Okumura, K; Shimizu, T; Takahashi, M; Takamori, A; Uchida, S; Urai, M; Yamada, H; Yamanishi, Y | 1 |
| Glenz, R; Krischke, M; Mueller, MJ; Schmalhaus, D; Waller, F | 1 |
| Čuříková-Kindlová, BA; Diat, O; Štěpánek, F; Vávrová, K; Zbytovská, J | 1 |
| Beddoes, CM; Bouwstra, JA; Gooris, GS; Uche, LE | 1 |
| Brakhage, AA; Denning, DW; Dolgov, E; Jiménez-Ortigosa, C; Kniemeyer, O; Krüger, T; Lee, MH; Park, S; Perlin, DS; Satish, S; Zhao, Y | 1 |
| Chen, X; Guo, HS; Ju, BH; Li, GZ; Liu, NJ; Liu, ZH; Qin, YM; Zhang, T; Zhang, YY; Zhou, QH; Zhu, YX | 1 |
| Arita, N; Sakamoto, R; Tani, M | 1 |
| Gupta, P; Nandi, AK; Roy, S | 1 |
| Bianco, M; Calvano, CD; Cataldi, TRI; Losito, I; Palmisano, F | 1 |
| Amorim, AA; Bikker, F; de Arruda, CNF; de Pires-de-Souza, FCP; Vivanco, RG | 1 |
| Cai, M; Gao, N; Han, G; Lu, L; Ma, X; Zhao, Z | 1 |
| Davis, JA; Harper, JF; López-Marqués, RL; Palmgren, M; Pares, RB | 1 |
| Ahn, J; Hahn, JS; Han, C; Han, MH; Jang, M; Kim, MJ; Lee, KR | 1 |
| Dickson, RC; Hepowit, NL; Liu, K; Macedo, JKA; MacGurn, JA; Sun, RC; Young, LEA | 1 |
| Liu, C; Liu, Y; Luo, M; Suo, X; Wang, L | 1 |
| Corpas, FJ; Díaz, C; Domínguez-Anaya, MÁ; González-Gordo, S; Guevara, L; Ortigosa, A; Palma, JM; Pérez Del Palacio, J; Vicente, F | 1 |
| Brezesinski, G; Dobner, B; Mukhina, T; Neubert, RHH; Oliveira, JSL; Opalka, L; Strati, F | 1 |
| Hama, Y; Higashiyama, S; Horitani, M; Kawaguchi, SI; Mitsutake, S; Nagasawa, T | 1 |
| Amirtharaj, LV; Ardhra, J; Keerthivasan, A; Rajkumar, K; Sekar, M; Vidhya, S | 1 |
| Akbaba, H; Altinöz, MA; Başpınar, Y; Erel-Akbaba, G; İsar, S; Nalbantsoy, A; Şahİn, Y | 1 |
| Fröschel, C; Glenz, R; Göpfert, D; Kaiping, A; Lambour, B; Mueller, MJ; Osman, M; Sylvester, M; Waller, F; Weber, H | 1 |
| Ajmal, A; Ajmal, M; Huang, L; Iqbal, S; Liu, B; Liu, Y; Luo, J; Rizvi, M; Shaikh, JA; Wang, Y; Zhang, L; Zhou, Q | 1 |
| Gedon, NKY; Kania, SA; Kühnle, C; Kühnle, HF; Mueller, RS; Raizner, NT; Zablotski, Y | 1 |
| Beddoes, CM; Bouwstra, JA; Dalgliesh, RM; Gooris, GS; Nădăban, A | 1 |
| Ivanchina, NV; Kalinovsky, AI; Kicha, AA; Kuzmich, AS; Malyarenko, OS; Malyarenko, TV; Popov, RS; Svetashev, VI; Zakharenko, VM | 1 |
| Chang, X; Cui, Q; Li, J; MacIsaac, HJ; Sun, C; Wen, J; Xu, J; Zhou, Y | 1 |
| Fan, Y; Hu, Q; Liu, B; Wang, W; Wen, F; Yu, U; Zheng, Y | 1 |
| Frank, JA; Franquelim, HG; Hartrampf, N; Leitao, SM; Schwille, P; Toombs-Ruane, H; Trauner, D; Winter, N | 1 |
| Jáger, D; Kešeľáková, A; Martinková, M; Pilátová, MB; Raschmanová, JŠ; Vargová, K | 1 |
| Beddoes, CM; Bouwstra, JA; Dalgliesh, RM; El Yachioui, D; Gooris, GS; Malfois, M; Nădăban, A; Rissmann, R; Rousel, J | 1 |
| Cui, L; Ji, X; Wang, K | 1 |
3 review(s) available for phytosphingosine and sphingosine
| Article | Year |
|---|---|
Biosynthesis of the sphingoid bases: a provocation.
Topics: Animals; Ceramides; Humans; Ketones; Models, Chemical; Oxidation-Reduction; Serine; Sphingolipids; Sphingosine | 1984 |
Integral hair lipid in human hair follicle.
Topics: Ceramides; Cholesterol Esters; Fatty Acids; Hair Follicle; Humans; Keratins; Lipid Metabolism; Permeability; Sphingosine | 2011 |
[Fermentative production of tetraacetyl phytosphingosine: a review].
Topics: Ceramides; Metabolic Engineering; Sphingosine; Synthetic Biology | 2023 |
2 trial(s) available for phytosphingosine and sphingosine
| Article | Year |
|---|---|
Effect of lipid-containing, positively charged nanoemulsions on skin hydration, elasticity and erythema--an in vivo study.
Topics: Administration, Topical; Adult; Chemistry, Pharmaceutical; Cosmetics; Elasticity; Emulsions; Female; Gelatin; Glycosphingolipids; Humans; Humidity; Membrane Lipids; Middle Aged; Nanotechnology; Oils; Skin; Sphingosine; Time Factors; Water; Water Loss, Insensible | 2006 |
Human Plasma Metabolomics Identify 9-cis-retinoic Acid and Dehydrophytosphingosine Levels as Novel biomarkers for Early Ventricular Fibrillation after ST-elevated Myocardial Infarction.
Topics: Adolescent; Adult; Aged; Alitretinoin; Biomarkers; Female; Humans; Male; Middle Aged; Sphingosine; ST Elevation Myocardial Infarction; Ventricular Fibrillation | 2022 |
233 other study(ies) available for phytosphingosine and sphingosine
| Article | Year |
|---|---|
Essential requirement for sphingosine kinase 2 in a sphingolipid apoptosis pathway activated by FTY720 analogues.
Topics: Animals; Apoptosis; Autoimmune Diseases; bcl-2-Associated X Protein; Calcium Signaling; Caspases; Cell Membrane Permeability; Drug Resistance, Neoplasm; Endoplasmic Reticulum; Fingolimod Hydrochloride; HeLa Cells; Humans; Immunosuppressive Agents; Jurkat Cells; Lymphoproliferative Disorders; Mice; Mice, Knockout; Mitochondria; Mutagenesis; Organ Specificity; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Propylene Glycols; Protein Transport; Receptors, Lysosphingolipid; Sphingolipids; Sphingosine; Spleen; Thymus Gland | 2007 |
Designer enzymes for glycosphingolipid synthesis by directed evolution.
Topics: Catalysis; Directed Molecular Evolution; Enzyme-Linked Immunosorbent Assay; Glycoside Hydrolases; Glycosphingolipids; Point Mutation; Rhodococcus; Substrate Specificity | 2009 |
Analysis and quantitation of free ceramide containing nonhydroxy and 2-hydroxy fatty acids, and phytosphingosine by high-performance liquid chromatography.
Topics: Aging; Animals; Brain; Ceramides; Chromatography, Gas; Chromatography, High Pressure Liquid; Colorimetry; Fatty Acids; Hydroxy Acids; Kidney; Liver; Mass Spectrometry; Rats; Sphingosine | 1979 |
Biosynthesis of phytosphingosine by the rat.
Topics: Animals; Chromatography, Gas; Germ-Free Life; Intestinal Mucosa; Kidney; Liver; Male; Mass Spectrometry; Rats; Sphingosine | 1977 |
Lipophosphonoglycan of the plasma membrane of A canthamoeba castellanii. Inositol and phytosphingosine content and general structural features.
Topics: Amoeba; Cell Membrane; Ceramides; Fatty Acids; Glycosphingolipids; Hexoses; Inositol; Organophosphonates; Phosphates; Sphingosine | 1976 |
Effect of sphingoid bases on basal and insulin-stimulated 2-deoxyglucose transport in skeletal muscle.
Topics: Animals; Biological Transport; Cytochalasin B; Deoxyglucose; In Vitro Techniques; Insulin; Kinetics; Male; Muscles; Rats; Rats, Sprague-Dawley; Sphingosine | 1992 |
Phenotypes of sphingolipid-dependent strains of Saccharomyces cerevisiae.
Topics: Fungal Proteins; Hydrogen-Ion Concentration; Kinetics; Leucine; Phenotype; Saccharomyces cerevisiae; Sphingolipids; Sphingosine; Temperature | 1992 |
Phytosphingosine-containing neutral glycosphingolipids and sulfatides in the human female genital tract: their association in the cervical epithelium and the uterine endometrium and their dissociation in the mucosa of fallopian tube with the menstrual cyc
Topics: Cervix Uteri; Endometrium; Epithelium; Fallopian Tubes; Female; Genitalia, Female; Glycosphingolipids; Humans; Menstrual Cycle; Mucous Membrane; Sphingosine; Sulfoglycosphingolipids | 1992 |
Sphingolipid long-chain-base auxotrophs of Saccharomyces cerevisiae: genetics, physiology, and a method for their selection.
Topics: Cell Division; Genes, Fungal; Genetic Complementation Test; Inositol; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Selection, Genetic; Serine C-Palmitoyltransferase; Sphingolipids; Sphingosine | 1992 |
Characterization of enzymatic synthesis of sphingolipid long-chain bases in Saccharomyces cerevisiae: mutant strains exhibiting long-chain-base auxotrophy are deficient in serine palmitoyltransferase activity.
Topics: Acyltransferases; Alcohol Oxidoreductases; Cell Membrane; Genetic Complementation Test; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Serine C-Palmitoyltransferase; Sphingolipids; Sphingosine | 1992 |
The determination of phytosphingosine-containing globotriaosylceramide from human kidney in the presence of lactosylceramide.
Topics: alpha-Galactosidase; Antigens, CD; Globosides; Glycosphingolipids; Humans; Kidney; Lactosylceramides; Magnetic Resonance Spectroscopy; Mass Spectrometry; Sphingosine; Trihexosylceramides | 1990 |
Quantitation of free sphingosine in liver by high-performance liquid chromatography.
Topics: Animals; Chromatography, High Pressure Liquid; Female; Liver; Rats; Rats, Inbred Strains; Sphingosine | 1988 |
Selective enrichment of phytosphingosine in glycosphingolipids of isolated human thyrocytes as compared to the whole thyroid.
Topics: Cell Separation; Glucosylceramides; Glycosphingolipids; Humans; Sphingosine; Thyroid Gland; Tissue Distribution | 1987 |
Phytosphingosine is a characteristic component of the glycolipids in the vertebrate intestine.
Topics: Animals; Glycolipids; Intestinal Mucosa; Species Specificity; Sphingosine; Vertebrates | 1987 |
Developmental changes of the lipidic part of the neutral glycosphingolipids of the rat stomach.
Topics: Animals; Fatty Acids; Fetus; Gangliosides; Gastric Mucosa; Glycosphingolipids; Rats; Rats, Inbred Strains; Sphingosine; Stomach; Tissue Distribution | 1985 |
Biosynthesis of 4D-hydroxysphinganine by the rat. En bloc incorporation of the sphinganine carbon backbone.
Topics: Animals; Chromatography, Thin Layer; Intestinal Mucosa; Isotope Labeling; Kidney; Male; Organ Specificity; Rats; Rats, Inbred Strains; Sphingosine; Tritium | 1984 |
Phytosphingosine in intestinal glycolipids of the rat fetus.
Topics: Animals; Animals, Newborn; Chromatography, Gas; Female; Fetus; Gestational Age; Glycolipids; Intestine, Small; Pregnancy; Rats; Rats, Inbred Strains; Sphingosine | 1984 |
Isolation and characterization of a novel phytosphingosine-containing GM2 ganglioside from mullet roe (Mugil cephalus).
Topics: Animals; Carbohydrate Conformation; Carbohydrate Sequence; Carbohydrates; Chromatography, Thin Layer; Fatty Acids; Female; Fishes; G(M2) Ganglioside; Gangliosides; Hydroxy Acids; Ovum; Sphingosine | 1984 |
Expression of new KDN-gangliosides in rainbow trout testis during spermatogenesis and their structural identification.
Topics: Acylation; Animals; Antibodies, Monoclonal; Carbohydrate Conformation; Carbohydrate Sequence; Chromatography, High Pressure Liquid; Chromatography, Thin Layer; Epitopes; Gangliosides; Indicators and Reagents; Male; Methylation; Molecular Sequence Data; Oligosaccharides; Oncorhynchus mykiss; Seasons; Sperm Maturation; Spermatogenesis; Sphingosine; Sugar Acids; Testis | 1995 |
Free sphingosines of human skin include 6-hydroxysphingosine and unusually long-chain dihydrosphingosines.
Topics: Animals; Chromatography, Thin Layer; Humans; Lipids; Magnetic Resonance Spectroscopy; Skin; Sphingosine; Swine | 1995 |
Expression of glycosphingolipids in serum-free primary cultures of mouse kidney cells: male-female differences and androgen sensitivity.
Topics: Androgens; Animals; Cells, Cultured; Chromatography, High Pressure Liquid; Culture Media, Serum-Free; Dihydrotestosterone; Epithelial Cells; Fatty Acids; Female; Galactosylceramides; Gene Expression Regulation; Glycosphingolipids; Kidney Tubules, Proximal; Male; Mice; Mice, Inbred C57BL; Mice, Mutant Strains; Sex Characteristics; Sphingosine; Testosterone; Trihexosylceramides | 1994 |
In vivo distribution of free long-chain sphingoid bases in the human stratum corneum by high-performance liquid chromatographic analysis of strippings.
Topics: Adult; Chromatography, High Pressure Liquid; Humans; Indicators and Reagents; Male; Middle Aged; o-Phthalaldehyde; Protein Kinase C; Proteins; Skin; Sphingolipids; Sphingosine | 1994 |
Suppressors of the Ca(2+)-sensitive yeast mutant (csg2) identify genes involved in sphingolipid biosynthesis. Cloning and characterization of SCS1, a gene required for serine palmitoyltransferase activity.
Topics: Acyltransferases; Amino Acid Sequence; Base Sequence; Cloning, Molecular; Genes, Fungal; Inositol; Molecular Sequence Data; Mutation; Phenotype; Saccharomyces cerevisiae; Sequence Analysis, DNA; Sequence Homology, Amino Acid; Serine C-Palmitoyltransferase; Sphingolipids; Sphingosine; Suppression, Genetic | 1994 |
Regulation of phosphatidate phosphatase activity from the yeast Saccharomyces cerevisiae by sphingoid bases.
Topics: Amines; Binding, Competitive; Cell Membrane; Kinetics; Molecular Weight; Phosphatidate Phosphatase; Psychosine; Saccharomyces cerevisiae; Sphingosine; Structure-Activity Relationship; Substrate Specificity | 1993 |
Sphingolipid synthesis as a target for antifungal drugs. Complementation of the inositol phosphorylceramide synthase defect in a mutant strain of Saccharomyces cerevisiae by the AUR1 gene.
Topics: Amino Acid Sequence; Antifungal Agents; Ceramides; Depsipeptides; Drug Resistance, Microbial; Fungal Proteins; Hexosyltransferases; Molecular Sequence Data; Peptides, Cyclic; Saccharomyces cerevisiae; Sphingolipids; Sphingosine | 1997 |
Identification of a Saccharomyces gene, LCB3, necessary for incorporation of exogenous long chain bases into sphingolipids.
Topics: Alleles; Amino Acid Sequence; Genes, Fungal; Membrane Proteins; Molecular Sequence Data; Saccharomyces cerevisiae; Sphingolipids; Sphingosine | 1997 |
Novel cationic liposomes for DNA-transfection with high efficiency and low toxicity.
Topics: Animals; Cations; Cell Line; Diglycerides; DNA; Liposomes; Phosphatidylethanolamines; Sphingosine; Transfection | 1997 |
Inhibition of amino acid transport by sphingoid long chain bases in Saccharomyces cerevisiae.
Topics: Amino Acid Transport Systems; Amino Acids; Amino Acids, Cyclic; Biological Transport; Carrier Proteins; Escherichia coli Proteins; Leucine; Membrane Transport Proteins; Proline; Saccharomyces cerevisiae; Sphingosine | 1998 |
Characterization of sphingosine kinase (SK) activity in Saccharomyces cerevisiae and isolation of SK-deficient mutants.
Topics: Cell Division; Cell Survival; Enzyme Activation; Enzyme Inhibitors; Heat-Shock Proteins; Hydrogen-Ion Concentration; Kinetics; Lysophospholipids; Mutation; Phenotype; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Saccharomyces cerevisiae; Sphingosine; Spores; Temperature | 1998 |
Phytosphingosine biosynthesis differs from sphingosine in fish leukocytes and involves a transfer of methyl groups from [3H-methyl]methionine precursor.
Topics: Animals; Bass; Chromatography, Gas; Chromatography, Thin Layer; Folic Acid; Leukocytes; Methylation; Niacinamide; Sphingosine; Tritium | 1998 |
The influence of carbon source on the level and composition of ceramides of the Candida lipolytica yeast.
Topics: Alkanes; Candida; Ceramides; Chromatography, Gas; Culture Media; Fatty Acids; Glucose; Lipids; Sphingosine | 1998 |
Novel glycoinositolphosphosphingolipids, basidiolipids, from Agaricus.
Topics: Adjuvants, Immunologic; Agaricus; Carbohydrate Sequence; Ceramides; Fatty Acids; Hydroxy Acids; Inositol Phosphates; Molecular Sequence Data; Nuclear Magnetic Resonance, Biomolecular; Phospholipids; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Sphingosine | 1999 |
Assay of the Saccharomyces cerevisiae dihydrosphingosine C-4 hydroxylase.
Topics: Ceramides; Chromatography, High Pressure Liquid; Chromatography, Thin Layer; Microsomes; Mixed Function Oxygenases; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Sphingosine; Substrate Specificity | 2000 |
Use of yeast as a model system for studies of sphingolipid metabolism and signaling.
Topics: Acetyltransferases; Acyltransferases; Chromatography, Thin Layer; Fungal Proteins; Growth Inhibitors; Membrane Proteins; Mixed Function Oxygenases; Phosphoric Monoester Hydrolases; Phosphotransferases (Alcohol Group Acceptor); Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Serine C-Palmitoyltransferase; Signal Transduction; Sphingolipids; Sphingosine | 2000 |
Inhibition of Ca2+ release channel (ryanodine receptor) activity by sphingolipid bases: mechanism of action.
Topics: Animals; Calcium Channel Blockers; In Vitro Techniques; Kinetics; Lipid Bilayers; Lysophospholipids; Muscle, Skeletal; Myocardium; Rabbits; Ryanodine; Ryanodine Receptor Calcium Release Channel; Sarcoplasmic Reticulum; Sphingolipids; Sphingosine | 2000 |
Purification of free sphingoid bases by solid-phase extraction on weak cation exchanger cartridges.
Topics: Chromatography, Ion Exchange; Chromatography, Thin Layer; Evaluation Studies as Topic; Glycosphingolipids; Sphingosine | 2000 |
Sphingolipids signal heat stress-induced ubiquitin-dependent proteolysis.
Topics: Acyltransferases; Endocytosis; Hot Temperature; Lysine; Peptide Hydrolases; Proteasome Endopeptidase Complex; Saccharomyces cerevisiae; Second Messenger Systems; Serine C-Palmitoyltransferase; Signal Transduction; Sphingosine; Spores, Fungal; Ubiquitins; Vacuoles | 2000 |
Stereospecific total syntheses of sphingosine and its analogues from L-serine.
Topics: Serine; Sphingosine; Stereoisomerism | 2000 |
Sphingoid base synthesis requirement for endocytosis in Saccharomyces cerevisiae.
Topics: Acyltransferases; Ceramides; Endocytosis; Mutation; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Serine C-Palmitoyltransferase; Sphingolipids; Sphingosine | 2000 |
Cloning and characterization of a Saccharomyces cerevisiae alkaline ceramidase with specificity for dihydroceramide.
Topics: Amidohydrolases; Amino Acid Sequence; Animals; Blotting, Western; Ceramidases; Ceramides; Codon; Databases, Factual; DNA Restriction Enzymes; Electrophoresis, Polyacrylamide Gel; Endoplasmic Reticulum; Escherichia coli; Fatty Acids; Gene Deletion; Green Fluorescent Proteins; Hot Temperature; Hydrogen-Ion Concentration; Hydrolysis; Luminescent Proteins; Molecular Sequence Data; Mutagenesis, Site-Directed; Palmitic Acid; Plasmids; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Sequence Homology, Amino Acid; Sphingosine; Substrate Specificity; Temperature | 2000 |
Differential labelling of sphingolipids by [3H]serine and ([3H]methyl)-methionine in fish leukocytes.
Topics: Animals; Bass; Isotope Labeling; Leukocytes; Serine; Sphingolipids; Sphingomyelins; Sphingosine; Tritium; Vitamin U | 2000 |
Analysis of sphingoid bases and sphingoid base 1-phosphates by high-performance liquid chromatography.
Topics: Blood Platelets; Cell Line; Chromatography, High Pressure Liquid; Humans; Indicators and Reagents; o-Phthalaldehyde; Phosphotransferases (Alcohol Group Acceptor); Spectrometry, Fluorescence; Sphingosine | 2000 |
Kinetic analysis of sphingoid base inhibition of yeast phosphatidate phosphatase.
Topics: Adenosine Triphosphate; Kinetics; Micelles; Phosphatidate Phosphatase; Phosphatidic Acids; Phosphorus Radioisotopes; Radioisotope Dilution Technique; Saccharomyces cerevisiae; Sphingosine; Tritium | 2000 |
A stereocontrolled, efficient synthetic route to bioactive sphingolipids: synthesis of phytosphingosine and phytoceramides from unsaturated ester precursors via cyclic sulfate intermediates.
Topics: Ceramides; Esters; Indicators and Reagents; Sphingolipids; Sphingosine; Stereoisomerism; Sulfates | 2000 |
Occurrence of ceramides and neutral glycolipids with unusual long-chain base composition in purified rat liver mitochondria.
Topics: Animals; Antigens, CD; Ceramides; Fatty Acids; Gas Chromatography-Mass Spectrometry; Glucosylceramides; Intracellular Membranes; Lactosylceramides; Mitochondria, Liver; Neutral Glycosphingolipids; Rats; Sphingosine | 2001 |
Functional characterization of sphingolipid C4-hydroxylase genes from Arabidopsis thaliana.
Topics: Arabidopsis; Base Sequence; DNA, Plant; Fatty Acid Desaturases; Gas Chromatography-Mass Spectrometry; Genes, Plant; Mixed Function Oxygenases; Molecular Sequence Data; Nuclear Magnetic Resonance, Biomolecular; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Sphingosine | 2001 |
Yeast 1,3-beta-glucan synthase activity is inhibited by phytosphingosine localized to the endoplasmic reticulum.
Topics: Base Sequence; DNA Primers; Endoplasmic Reticulum; Enzyme Inhibitors; Glucosyltransferases; Membrane Proteins; Saccharomyces cerevisiae; Schizosaccharomyces pombe Proteins; Sphingosine | 2001 |
C26-CoA-dependent ceramide synthesis of Saccharomyces cerevisiae is operated by Lag1p and Lac1p.
Topics: Acyl Coenzyme A; Ceramides; Endoplasmic Reticulum; Fatty Acids; Fungal Proteins; Gas Chromatography-Mass Spectrometry; Genotype; Glycosylphosphatidylinositols; Kinetics; Membrane Proteins; Microsomes; Mutation; Protein Transport; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Sphingolipids; Sphingosine | 2001 |
Phytosphingosine and C2-phytoceramide induce cell death and inhibit carbachol-stimulated phospholipase D activation in Chinese hamster ovary cells expressing the Caenorhabditis elegans muscarinic acetylcholine receptor.
Topics: Animals; Apoptosis; Caenorhabditis elegans; Carbachol; Cell Division; Ceramides; CHO Cells; Cricetinae; DNA Fragmentation; Dose-Response Relationship, Drug; Enzyme Activation; Nucleosomes; Phospholipase D; Receptors, Muscarinic; Signal Transduction; Sphingosine; Time Factors; Type C Phospholipases | 2001 |
Phytosphingosine as a specific inhibitor of growth and nutrient import in Saccharomyces cerevisiae.
Topics: Biological Transport; Culture Media; Saccharomyces cerevisiae; Sphingosine | 2001 |
Characterization of novel structures of mannosylinositolphosphorylceramides from the yeast forms of Sporothrix schenckii.
Topics: Carbohydrate Sequence; Carbohydrates; Ceramides; Fatty Acids; Glycosphingolipids; Inositol; Lipids; Magnetic Resonance Spectroscopy; Mass Spectrometry; Methylation; Molecular Sequence Data; Oligosaccharides; Polysaccharides; Protein Conformation; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Sphingosine; Sporothrix | 2001 |
Sphingoid base signaling via Pkh kinases is required for endocytosis in yeast.
Topics: 3-Phosphoinositide-Dependent Protein Kinases; Actins; Cytoskeleton; Dose-Response Relationship, Drug; Endocytosis; Genotype; Microscopy, Fluorescence; Mutation; Phalloidine; Phosphorylation; Plasmids; Precipitin Tests; Protein Kinases; Protein Serine-Threonine Kinases; Rhodamines; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Signal Transduction; Sphingosine; Time Factors | 2001 |
Comparative analysis of glycosylinositol phosphorylceramides from fungi by electrospray tandem mass spectrometry with low-energy collision-induced dissociation of Li(+) adduct ions.
Topics: Agaricus; Aspergillus fumigatus; Ceramides; Glycosphingolipids; Histoplasma; Lithium; Spectrometry, Mass, Electrospray Ionization; Sphingosine; Sporothrix | 2001 |
Identification of target tissue glycosphingolipid receptors for uropathogenic, F1C-fimbriated Escherichia coli and its role in mucosal inflammation.
Topics: Animals; Bacterial Adhesion; Chromatography, Thin Layer; Dogs; Escherichia coli; Escherichia coli Infections; Galactosylceramides; Glycosphingolipids; Humans; Interleukin-8; Magnetic Resonance Spectroscopy; Mucous Membrane; Rats; Receptors, Immunologic; Sphingosine; Trihexosylceramides; Urinary Tract; Urinary Tract Infections | 2002 |
Dependence of the sphingoid bases concentration on growth phase and temperature in the yeast Yarrowia lipolytica.
Topics: Chromatography, High Pressure Liquid; Culture Media; Sphingolipids; Sphingosine; Temperature; Yarrowia | 2002 |
Yeast cells lacking the ARV1 gene harbor defects in sphingolipid metabolism. Complementation by human ARV1.
Topics: Ceramides; DNA, Complementary; Endoplasmic Reticulum; Gas Chromatography-Mass Spectrometry; Genetic Complementation Test; Golgi Apparatus; Green Fluorescent Proteins; Humans; Inositol; Lipid Metabolism; Luminescent Proteins; Membrane Proteins; Microscopy, Fluorescence; Mutation; Plasmids; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Sphingolipids; Sphingosine; Temperature; Time Factors | 2002 |
Glycosphingolipids from Magnaporthe grisea cells: expression of a ceramide dihexoside presenting phytosphingosine as the long-chain base.
Topics: Carbohydrate Conformation; Glycosphingolipids; Glycosylation; Magnaporthe; Magnetic Resonance Spectroscopy; Molecular Structure; Spectrometry, Mass, Fast Atom Bombardment; Sphingosine | 2002 |
In vitro activity of phytosphingosines against Malassezia furfur and Candida albicans.
Topics: Candida albicans; Colony Count, Microbial; Humans; Malassezia; Microbial Sensitivity Tests; Sphingosine; Staphylococcus | 2002 |
Analysis of ceramides in cosmetics by reversed-phase liquid chromatography/electrospray ionization mass spectrometry with collision-induced dissociation.
Topics: Calibration; Ceramides; Chromatography, Liquid; Cosmetics; Drug Contamination; Molecular Structure; Quality Control; Reference Standards; Spectrometry, Mass, Electrospray Ionization; Sphingosine | 2003 |
Induction of apoptosis by sphingoid long-chain bases in Aspergillus nidulans.
Topics: Antifungal Agents; Apoptosis; Aspergillus nidulans; Base Sequence; Biomarkers; Caspases; DNA Fragmentation; DNA, Fungal; Fungal Proteins; Gene Deletion; Mitochondria; Mitosis; Molecular Sequence Data; Mutation; Reactive Oxygen Species; Saccharomyces cerevisiae Proteins; Sphingosine; Structure-Activity Relationship | 2003 |
Phytosphingosine induces apoptotic cell death via caspase 8 activation and Bax translocation in human cancer cells.
Topics: Apoptosis; bcl-2-Associated X Protein; Carcinoma, Non-Small-Cell Lung; Caspase 8; Caspase 9; Caspases; Enzyme Activation; Flow Cytometry; Humans; Lung Neoplasms; Lymphoma, T-Cell; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Sphingosine; Tumor Cells, Cultured | 2003 |
New acylceramide in native and reconstructed epidermis.
Topics: Cell Fractionation; Cells, Cultured; Ceramides; Chromatography, Gas; Epidermal Cells; Epidermis; Fatty Acids; Humans; Magnetic Resonance Spectroscopy; Organ Culture Techniques; Sphingosine | 2003 |
Synthesis of 4-hydroxysphinganine and characterization of sphinganine hydroxylase activity in corn.
Topics: beta-Alanine; Cells, Cultured; Enzyme Activation; Fumonisins; Microsomes; Mixed Function Oxygenases; Plant Shoots; Sphingosine; Zea mays | 2003 |
A facile synthesis of phytosphingosine from diisopropylidene-D-mannofuranose.
Topics: Lipids; Mannose; Sphingosine | 2003 |
Distribution of sphingosine kinase activity in mouse tissues: contribution of SPHK1.
Topics: Animals; Apoptosis; Blood Platelets; Catalysis; Cell Differentiation; Cell Movement; CHO Cells; Cricetinae; Immunoblotting; Male; Mice; Mice, Inbred C57BL; Phosphotransferases (Alcohol Group Acceptor); Precipitin Tests; Sphingosine; Subcellular Fractions; Tissue Distribution | 2003 |
LIPID COMPONENTS OF LEAVES. IV. OCCURENCE OF PHYTOSPHINGOSINE AND DEHYDROPHYTOSPHINGOSINE-CONTAINING GLUCOCEREBROSIDES.
Topics: Cerebrosides; Chromatography; Glucosylceramides; Glycerides; Glycolipids; Lipids; Phospholipids; Plants; Research; Sphingosine | 1964 |
SYNTHESIS OF PHYTOSPHINGOSINE.
Topics: Amino Alcohols; Chemical Phenomena; Chemistry; Research; Sphingosine | 1965 |
Suppression of extracellular signal-related kinase and activation of p38 MAPK are two critical events leading to caspase-8- and mitochondria-mediated cell death in phytosphingosine-treated human cancer cells.
Topics: Apoptosis; bcl-2-Associated X Protein; Blotting, Western; Caspase 8; Caspase 9; Caspases; Cell Death; Cell Line; Cell Line, Tumor; Cytochromes c; Cytosol; Down-Regulation; Enzyme Activation; Enzyme Inhibitors; Flow Cytometry; Humans; Jurkat Cells; Membrane Potentials; Microscopy, Fluorescence; Mitochondria; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Models, Biological; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Plasmids; Protein Transport; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Sphingosine; Tetradecanoylphorbol Acetate; Time Factors | 2003 |
Metabolomic profiling of sphingolipids in human glioma cell lines by liquid chromatography tandem mass spectrometry.
Topics: Astrocytoma; Cell Line, Tumor; Ceramides; Chromatography, High Pressure Liquid; Fatty Acids; Galactosylceramides; Glioblastoma; Glioma; Glucosylceramides; Humans; Lactosylceramides; Lysophospholipids; Molecular Structure; Spectrometry, Mass, Electrospray Ionization; Sphingolipids; Sphingomyelins; Sphingosine | 2003 |
Differential regulation of cyclooxygenase-2 expression by phytosphingosine derivatives, NAPS and TAPS, and its role in the NAPS or TAPS-mediated apoptosis.
Topics: Apoptosis; Cell Line; Cell Survival; Cyclooxygenase 2; Dose-Response Relationship, Drug; Gene Expression Regulation; Humans; Isoenzymes; Membrane Proteins; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Prostaglandin-Endoperoxide Synthases; Protein Kinase C; Sphingosine; src-Family Kinases | 2003 |
Tetraacetyl phytosphingosine-induced caspase activation and apoptosis occur through G2 arrest in human keratinocyte HaCaT cells.
Topics: Apoptosis; Caspases; Cell Line; Enzyme Activation; G2 Phase; Humans; Keratinocytes; Sphingosine; Time Factors | 2003 |
Sphingolipids as bioactive regulators of thrombin generation.
Topics: Anticoagulants; Binding Sites; Blood Platelets; Carbon; Dose-Response Relationship, Drug; Down-Regulation; Factor Va; Factor Xa; Gene Expression Regulation; Humans; Inhibitory Concentration 50; Lipid Metabolism; Lipids; Micelles; Phosphorylcholine; Protein Binding; Protein Structure, Tertiary; Prothrombin; Psychosine; Sphingolipids; Sphingosine; Thrombin | 2004 |
Induction of apoptosis and expression of cell cycle regulatory proteins in response to a phytosphingosine derivative in HaCaT human keratinocyte cells.
Topics: Apoptosis; Caspases; Cell Cycle; Cell Cycle Proteins; Cell Division; Enzyme Activation; Humans; Keratinocytes; Sphingosine | 2003 |
Newly discovered neutral glycosphingolipids in aureobasidin A-resistant zygomycetes: Identification of a novel family of Gala-series glycolipids with core Gal alpha 1-6Gal beta 1-6Gal beta sequences.
Topics: Absidia; Antifungal Agents; Aspergillus; Carbohydrates; Chromatography, Thin Layer; Depsipeptides; Drug Resistance; Gas Chromatography-Mass Spectrometry; Glycolipids; Glycoside Hydrolases; Glycosphingolipids; Magnetic Resonance Spectroscopy; Models, Chemical; Mucor; Mucormycosis; Multigene Family; Penicillium; Peptides, Cyclic; Rhizopus; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Sphingolipids; Sphingosine | 2004 |
Genetic, biochemical, and transcriptional responses of Saccharomyces cerevisiae to the novel immunomodulator FTY720 largely mimic those of the natural sphingolipid phytosphingosine.
Topics: Amino Acids; Biological Transport; Cell Division; Cell Membrane; Cytoskeleton; DNA, Complementary; Down-Regulation; Escherichia coli; Fingolimod Hydrochloride; Genotype; Immunoblotting; Immunosuppressive Agents; Mutation; Oligonucleotide Array Sequence Analysis; Phosphotransferases (Alcohol Group Acceptor); Plasmids; Polymerase Chain Reaction; Propylene Glycols; Reverse Transcriptase Polymerase Chain Reaction; RNA; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Sphingolipids; Sphingosine; Transcription, Genetic; Up-Regulation | 2004 |
Potentiation of UVB-induced apoptosis by novel phytosphingosine derivative, tetraacetyl phytosphingosine in HaCaT cell and mouse skin.
Topics: Acetylation; Animals; Apoptosis; bcl-2-Associated X Protein; Blotting, Western; Caspase 3; Caspase 8; Caspase 9; Caspases; Cell Line, Transformed; Cell Survival; Cytochromes c; Dermis; Epidermal Cells; Epidermis; Flow Cytometry; Humans; In Situ Nick-End Labeling; Keratinocytes; Mice; Mice, Hairless; Proto-Oncogene Proteins c-bcl-2; Skin; Sphingosine; Ultraviolet Rays | 2004 |
Effective, high-yielding, and stereospecific total synthesis of D-erythro-(2R,3S)-sphingosine from D-ribo-(2S,3S,4R)-phytosphingosine.
Topics: Brain; Catalysis; Indicators and Reagents; Molecular Structure; Sphingosine; Stereoisomerism | 2004 |
Acylceramide head group architecture affects lipid organization in synthetic ceramide mixtures.
Topics: Acylation; Ceramides; Cholesterol; Epidermis; Fatty Acids, Nonesterified; In Vitro Techniques; Sphingosine; X-Ray Diffraction | 2004 |
Phytosphingosine in combination with ionizing radiation enhances apoptotic cell death in radiation-resistant cancer cells through ROS-dependent and -independent AIF release.
Topics: Active Transport, Cell Nucleus; Apoptosis; Apoptosis Inducing Factor; bcl-2-Associated X Protein; Cell Nucleus; Clone Cells; Combined Modality Therapy; Enzyme Activation; Flavoproteins; Gamma Rays; Humans; Intracellular Membranes; Jurkat Cells; Membrane Potentials; Membrane Proteins; Mitochondria; Poly(ADP-ribose) Polymerases; Proto-Oncogene Proteins c-bcl-2; Radiation Tolerance; Reactive Oxygen Species; Sphingosine | 2005 |
Polymorphism of ceramide 6: a vibrational spectroscopic and X-ray powder diffraction investigation of the diastereomers of N-(alpha-hydroxyoctadecanoyl)-phytosphingosine.
Topics: Calorimetry; Ceramides; Chromatography, Thin Layer; Molecular Structure; Powder Diffraction; Spectroscopy, Fourier Transform Infrared; Spectrum Analysis, Raman; Sphingosine; Stereoisomerism; Structure-Activity Relationship; Vibration; X-Ray Diffraction | 2005 |
Phytosphingosine induced mitochondria-involved apoptosis.
Topics: Apoptosis; Caspases; Cytochromes c; DNA Fragmentation; Dose-Response Relationship, Drug; Humans; Membrane Potentials; Mitochondria; Phosphorylation; Proto-Oncogene Proteins c-bcl-2; Sphingosine | 2005 |
FTIR spectroscopic studies of lipid dynamics in phytosphingosine ceramide models of the stratum corneum lipid matrix.
Topics: Ceramides; Lipids; Models, Chemical; Skin; Spectroscopy, Fourier Transform Infrared; Sphingosine; Water | 2005 |
The sphingoid long chain base phytosphingosine activates AGC-type protein kinases in Saccharomyces cerevisiae including Ypk1, Ypk2, and Sch9.
Topics: 3-Phosphoinositide-Dependent Protein Kinases; Electrophoresis, Polyacrylamide Gel; Enzyme Activation; Gene Expression Regulation, Fungal; Genetic Complementation Test; Glycogen Synthase Kinase 3; Histidine; Hot Temperature; Immunoprecipitation; Kinetics; Lipid Metabolism; Models, Biological; Mutation; Phenotype; Phosphorylation; Plasmids; Protein Binding; Protein Kinases; Protein Serine-Threonine Kinases; Protein Structure, Tertiary; Protein-Tyrosine Kinases; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Sphingosine; Time Factors | 2005 |
Design of a phytosphingosine-containing, positively-charged nanoemulsion as a colloidal carrier system for dermal application of ceramides.
Topics: Calorimetry, Differential Scanning; Ceramides; Colloids; Cryoelectron Microscopy; Drug Carriers; Drug Design; Drug Stability; Electrochemistry; Emulsions; Microspheres; Particle Size; Skin Absorption; Solubility; Sphingosine; Viscosity | 2005 |
Regulation of the sphingoid long-chain base kinase Lcb4p by ergosterol and heme: studies in phytosphingosine-resistant mutants.
Topics: Biomarkers; Cell Membrane; DNA Transposable Elements; DNA-Binding Proteins; Ergosterol; Gene Expression Regulation, Fungal; Heme; Mutagenesis; Mutation; Phosphoric Monoester Hydrolases; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Sphingosine; Trans-Activators; Transcription Factors | 2005 |
Anti-ulcer actions of phytosphingosine hydrochloride in different experimental rat ulcer models.
Topics: Animals; Anti-Ulcer Agents; Central Nervous System Depressants; Cysteamine; Duodenal Ulcer; Ethanol; Gastric Acid; Gastric Mucosa; Hydrochloric Acid; Ligation; Male; Prostaglandins; Pylorus; Rats; Rats, Sprague-Dawley; Sphingosine; Stomach Ulcer; Ulcer | 2005 |
Influence of phytosphingosine-type ceramides on the structure of DMPC membrane.
Topics: Ceramides; Dimyristoylphosphatidylcholine; Membrane Fluidity; Membranes, Artificial; Neutron Diffraction; Sphingosine; Sucrose; Water; X-Ray Diffraction | 2005 |
Signalling functions for sphingolipid long-chain bases in Saccharomyces cerevisiae.
Topics: Animals; Hot Temperature; Mammals; Protein Kinases; Saccharomyces cerevisiae; Signal Transduction; Sphingolipids; Sphingosine | 2005 |
Candida albicans serotype B strains synthesize a serotype-specific phospholipomannan overexpressing a beta-1,2-linked mannotriose.
Topics: Antigens, Fungal; Candida albicans; Ceramides; Epitopes; Fatty Acids; Gas Chromatography-Mass Spectrometry; Glycolipids; Glycosylation; Hydroxylation; Mannosyltransferases; Molecular Weight; Nuclear Magnetic Resonance, Biomolecular; Serotyping; Sphingolipids; Sphingosine; Trisaccharides | 2005 |
Long chain base tolerance in Saccharomyces cerevisiae is induced by retrograde signals from the mitochondria.
Topics: Cell Membrane; DNA-Binding Proteins; Glycosylation; Membrane Proteins; Mitochondria; Mutation; Promoter Regions, Genetic; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Signal Transduction; Sphingosine; Transcription Factors | 2006 |
An efficient synthesis of the natural tetrahydrofuran pachastrissamine starting from D-ribo-phytosphingosine.
Topics: Furans; Indicators and Reagents; Models, Molecular; Molecular Conformation; Ribose; Sphingosine | 2006 |
A general, efficient and stereospecific route to sphingosine, sphinganines, phytosphingosines and their analogs.
Topics: Cancer Vaccines; Indicators and Reagents; Mass Spectrometry; Molecular Conformation; Sphingosine; Stereoisomerism | 2006 |
Rapid demonstration of diversity of sulfatide molecular species from biological materials by MALDI-TOF MS.
Topics: Animals; Brain Chemistry; Cattle; Ceramides; Erythrocytes; Fatty Acids; Glycosphingolipids; Humans; Hydroxylation; Mass Spectrometry; Rats; Rats, Inbred F344; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Sphingosine; Sulfoglycosphingolipids; Swine; Tissue Distribution | 2006 |
An efficient high-yield synthesis of D-ribo-phytosphingosine.
Topics: Aldehydes; Catalysis; Molecular Structure; Sphingosine; Stereoisomerism | 2006 |
Identification of mouse sphingomyelin synthase 1 as a suppressor of Bax-mediated cell death in yeast.
Topics: Animals; Apoptosis; bcl-2-Associated X Protein; Ceramides; Hexosyltransferases; Hot Temperature; Hydrogen Peroxide; Mice; Osmolar Concentration; Saccharomyces cerevisiae; Sphingosine; Transferases (Other Substituted Phosphate Groups) | 2006 |
Characterization of Ca2+ influx induced by dimethylphytosphingosine and lysophosphatidylcholine in U937 monocytes.
Topics: Biological Transport; Calcium; Calcium Signaling; Cell Membrane; Humans; Lysophosphatidylcholines; Monocytes; Sphingosine; TRPM Cation Channels; U937 Cells | 2006 |
Efficient synthesis of D-erythro-sphingosine and D-erythro-azidosphingosine from D-ribo-phytosphingosine via a cyclic sulfate intermediate.
Topics: Cyclization; Molecular Structure; Sphingosine; Sulfates | 2006 |
Phytosphingosine in combination with TRAIL sensitizes cancer cells to TRAIL through synergistic up-regulation of DR4 and DR5.
Topics: Antineoplastic Combined Chemotherapy Protocols; Apoptosis; bcl-2 Homologous Antagonist-Killer Protein; bcl-2-Associated X Protein; BH3 Interacting Domain Death Agonist Protein; Carcinoma, Non-Small-Cell Lung; Caspase 8; Drug Synergism; Enzyme Activation; Humans; Jurkat Cells; Lung Neoplasms; Lymphoma, T-Cell; Mitochondria; NF-kappa B; Receptors, TNF-Related Apoptosis-Inducing Ligand; Receptors, Tumor Necrosis Factor; Recombinant Proteins; Sphingosine; T-Lymphocytes; TNF-Related Apoptosis-Inducing Ligand; Up-Regulation | 2007 |
Combination treatment with arsenic trioxide and phytosphingosine enhances apoptotic cell death in arsenic trioxide-resistant cancer cells.
Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Arsenic Trioxide; Arsenicals; bcl-2-Associated X Protein; Drug Resistance, Neoplasm; Enzyme Activation; Humans; Mitochondria; Models, Biological; Neoplasms; Oxides; p38 Mitogen-Activated Protein Kinases; Poly(ADP-ribose) Polymerases; Protein Transport; Reactive Oxygen Species; Sphingosine | 2007 |
Synthesis of pachastrissamine from phytosphingosine: a comparison of cyclic sulfate vs an epoxide intermediate in cyclization.
Topics: Cyclization; Epoxy Compounds; Models, Chemical; Sphingosine; Sulfates | 2007 |
Dihydroxylation of 2-vinylaziridine: efficient synthesis of D-ribo-phytosphingosine.
Topics: Aziridines; Catalysis; Hydroxylation; Molecular Conformation; Molecular Structure; Osmium; Sphingosine; Stereoisomerism | 2007 |
Selective substrate supply in the regulation of yeast de novo sphingolipid synthesis.
Topics: Adaptor Proteins, Signal Transducing; Carrier Proteins; Gene Deletion; Gene Expression Regulation; Gene Expression Regulation, Fungal; Hot Temperature; Hydrogen-Ion Concentration; Membrane Proteins; Models, Biological; Mutagenesis; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Serine; Sphingolipids; Sphingosine; Substrate Specificity; Time Factors | 2007 |
Anti-angiogenic effect of tetraacetyl-phytosphingosine.
Topics: Acetylation; Animals; Calcium; Cell Movement; Cells, Cultured; Endothelial Cells; Extracellular Signal-Regulated MAP Kinases; Humans; JNK Mitogen-Activated Protein Kinases; Matrix Metalloproteinase 2; Neovascularization, Physiologic; Phosphorylation; Plasminogen Activator Inhibitor 1; Rabbits; Signal Transduction; Sphingosine; Umbilical Veins; Urokinase-Type Plasminogen Activator; Vascular Endothelial Growth Factor A; Wound Healing | 2007 |
basA regulates cell wall organization and asexual/sexual sporulation ratio in Aspergillus nidulans.
Topics: Aspergillus nidulans; Cell Wall; Fungal Proteins; Gene Expression Regulation, Fungal; Hyphae; Oxidoreductases; Sphingolipids; Sphingosine; Spores, Fungal; Transcription, Genetic | 2007 |
Minimum structure requirement of immunomodulatory glycolipids for predominant Th2 cytokine induction and the discovery of non-linear phytosphingosine analogs.
Topics: Animals; Cytokines; Glycolipids; Humans; Immunologic Factors; Molecular Structure; Sphingosine; Th2 Cells | 2007 |
A higher plant delta8 sphingolipid desaturase with a preference for (Z)-isomer formation confers aluminum tolerance to yeast and plants.
Topics: Aluminum; Arabidopsis; DNA, Complementary; Fabaceae; Genes, Plant; Oxidoreductases; Plants, Genetically Modified; Saccharomyces cerevisiae; Sphingosine | 2007 |
Synthesis of novel phytosphingosine derivatives and their preliminary biological evaluation for enhancing radiation therapy.
Topics: Apoptosis; Combined Modality Therapy; Drug Evaluation, Preclinical; Humans; Jurkat Cells; Leukemia, T-Cell; Radiation-Sensitizing Agents; Sphingosine | 2007 |
Involvement of sphingoid bases in mediating reactive oxygen intermediate production and programmed cell death in Arabidopsis.
Topics: Apoptosis; Arabidopsis; Arabidopsis Proteins; Fumonisins; Genome, Plant; Mutation; Phosphorylation; Protein Subunits; Reactive Oxygen Species; Serine C-Palmitoyltransferase; Signal Transduction; Sphingolipids; Sphingosine | 2007 |
Efficient and selective synthesis of D-arabino-, D-lyxo-, and D-xylo-phytosphingosine from D-ribo-phytosphingosine.
Topics: Isomerism; Magnetic Resonance Spectroscopy; Spectrometry, Mass, Fast Atom Bombardment; Sphingosine | 2008 |
Targeting lipid metabolism in the treatment of hepatitis C virus infection.
Topics: Carcinoma, Hepatocellular; Cell Line, Tumor; Hepacivirus; Hepatitis C; Humans; Lipids; Liver Neoplasms; Plasmids; Reverse Transcriptase Polymerase Chain Reaction; RNA, Small Interfering; Sphingosine; Virus Replication | 2008 |
Divergent syntheses of all stereoisomers of phytosphingosine and their use in the construction of a ceramide library.
Topics: Ceramides; Chromatography, Liquid; Chromatography, Thin Layer; Combinatorial Chemistry Techniques; Magnetic Resonance Spectroscopy; Molecular Structure; Spectrometry, Mass, Electrospray Ionization; Sphingosine; Stereoisomerism | 2008 |
Increased resistance of complex I mutants to phytosphingosine-induced programmed cell death.
Topics: Apoptosis; Apoptosis Inducing Factor; DNA Fragmentation; Electron Transport Complex I; Fungal Proteins; Hydrogen Peroxide; Mitochondrial Proteins; Mutation; Neurospora crassa; Sphingosine | 2008 |
Fungicidal activity of truncated analogues of dihydrosphingosine.
Topics: Animals; Antifungal Agents; Candida albicans; Candida glabrata; Carbon; Chemistry, Pharmaceutical; Drug Design; Humans; Models, Chemical; Molecular Conformation; Oxygen; Reactive Oxygen Species; Sphingosine; Technology, Pharmaceutical | 2008 |
Evaluation of four topical preparations for the treatment of cannon hyperkeratosis in a horse.
Topics: Adapalene; Animals; Anti-Inflammatory Agents, Non-Steroidal; Female; Horse Diseases; Horses; Immunosuppressive Agents; Keratitis; Naphthalenes; Sphingosine; Tacrolimus | 2008 |
Synthesis and biological properties of Pachastrissamine (jaspine B) and diastereoisomeric jaspines.
Topics: Autophagy; Cell Death; Cell Line; Ceramides; Cyclization; Dose-Response Relationship, Drug; Humans; Sphingosine; Stereoisomerism | 2009 |
Lecithin based nanoemulsions: A comparative study of the influence of non-ionic surfactants and the cationic phytosphingosine on physicochemical behaviour and skin permeation.
Topics: Administration, Topical; Animals; Anti-Inflammatory Agents; Calorimetry, Differential Scanning; Chemistry, Pharmaceutical; Drug Compounding; Drug Delivery Systems; Drug Stability; Electrochemistry; Fludrocortisone; Flumethasone; In Vitro Techniques; Nanoparticles; Particle Size; Polysorbates; Skin; Skin Absorption; Solubility; Sphingosine; Sucrose; Surface-Active Agents; Swine | 2009 |
Achieving molecular complexity by organocatalytic one-pot strategies - a fast entry for synthesis of sphingoids, amino sugars, and polyhydroxylated alpha-amino acids.
Topics: Amino Acids; Amino Sugars; Catalysis; Cyclization; Sphingosine; Stereoisomerism | 2009 |
Transcriptional analysis of the response of Neurospora crassa to phytosphingosine reveals links to mitochondrial function.
Topics: Apoptosis; Drug Administration Schedule; Electron Transport Complex I; Gene Expression Profiling; Gene Expression Regulation, Fungal; Genes, Fungal; Genes, Mitochondrial; Hydrogen Peroxide; Mitochondria; Neurospora crassa; Oxidants; Sphingosine; Transcription, Genetic | 2009 |
Metabonomics research of diabetic nephropathy and type 2 diabetes mellitus based on UPLC-oaTOF-MS system.
Topics: Adult; Aged; Biomarkers; Chromatography, High Pressure Liquid; Cluster Analysis; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Female; Humans; Leucine; Male; Metabolome; Metabolomics; Middle Aged; Principal Component Analysis; Spectrometry, Mass, Electrospray Ionization; Sphingosine | 2009 |
Analysis of skin penetration of phytosphingosine by fluorescence detection and influence of the thermotropic behaviour of DPPC liposomes.
Topics: 1,2-Dipalmitoylphosphatidylcholine; Animals; Chromatography, High Pressure Liquid; Drug Interactions; Liposomes; Models, Biological; Models, Chemical; Particle Size; Skin Absorption; Spectrometry, Fluorescence; Sphingosine; Swine; Temperature | 2010 |
Efficient synthesis of D-xylo and D-ribo-phytosphingosines from methyl 2-amino-2-deoxy-beta-D-hexopyranosides.
Topics: Methylglycosides; Sphingosine | 2009 |
Influence of a phytosphingosine-containing chlorhexidine shampoo on superficial bacterial counts and bacterial adherence to canine keratinocytes.
Topics: Animals; Bacterial Adhesion; Baths; Chlorhexidine; Disinfectants; Dogs; Keratinocytes; Sphingosine; Staphylococcus | 2010 |
Phytosphingosine kills Candida albicans by disrupting its cell membrane.
Topics: Antifungal Agents; Candida albicans; Cell Membrane; Cell Membrane Permeability; Histatins; Sodium Azide; Sphingosine | 2010 |
Cytotoxic effects of novel phytosphingosine derivatives, including N,N-dimethylphytosphingosine and N-monomethylphytosphingosine, in human leukemia cell line HL60.
Topics: Antineoplastic Agents; Apoptosis; Caspase Inhibitors; Cell Cycle; Cell Line, Tumor; Cell Survival; Chemistry, Pharmaceutical; Drug Design; Drug Screening Assays, Antitumor; Gene Expression Regulation, Leukemic; HL-60 Cells; Humans; Leukemia; Sphingosine | 2010 |
Skn1 and Ipt1 negatively regulate autophagy in Saccharomyces cerevisiae.
Topics: Apoptosis; Autophagy; Cell Membrane; DNA Fragmentation; Gene Deletion; Gene Expression Regulation, Fungal; Membrane Proteins; Nitrogen; Phosphotransferases (Alcohol Group Acceptor); Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Sphingosine | 2010 |
Enhancement of stability and skin permeation by sucrose stearate and cyclodextrins in progesterone nanoemulsions.
Topics: alpha-Cyclodextrins; Animals; beta-Cyclodextrins; Calorimetry, Differential Scanning; Chemistry, Pharmaceutical; Cryoelectron Microscopy; Cyclodextrins; Drug Compounding; Drug Stability; Emulsions; Excipients; gamma-Cyclodextrins; Microscopy, Electron, Transmission; Nanoparticles; Permeability; Progesterone; Skin; Skin Absorption; Sphingosine; Sucrose; Surface Properties; Swine; Technology, Pharmaceutical; Time Factors | 2010 |
N,N-Dimethyl phytosphingosine sensitizes HL-60/MX2, a multidrug-resistant variant of HL-60 cells, to doxorubicin-induced cytotoxicity through ROS-mediated release of cytochrome c and AIF.
Topics: Acetylcysteine; Amino Acid Chloromethyl Ketones; Antibiotics, Antineoplastic; Antioxidants; Apoptosis Inducing Factor; Caspase Inhibitors; Caspases; Cell Survival; Cysteine Proteinase Inhibitors; Cytochromes c; Doxorubicin; Drug Resistance, Multiple; Enzyme Activation; Free Radical Scavengers; HL-60 Cells; Humans; Mitochondria; Reactive Oxygen Species; Sphingosine | 2010 |
Asymmetric synthesis of D-ribo-phytosphingosine from 1-tetradecyne and (4-methoxyphenoxy)acetaldehyde.
Topics: Acetaldehyde; Alkylation; Alkynes; Azides; Catalysis; Galactosylceramides; Magnetic Resonance Spectroscopy; Molecular Structure; Sphingosine; Stereoisomerism | 2010 |
Anti-scratching behavioral effects of N-stearoyl-phytosphingosine and 4-hydroxysphinganine in mice.
Topics: Animals; Anti-Allergic Agents; Antipruritics; Ceramides; Guinea Pigs; Histamine; Interleukin-4; Mice; NF-kappa B; Pruritus; Sphingosine; Tumor Necrosis Factor-alpha | 2010 |
Pseudomonas syringae infection triggers de novo synthesis of phytosphingosine from sphinganine in Arabidopsis thaliana.
Topics: Apoptosis; Arabidopsis; Mixed Function Oxygenases; Plant Leaves; Pseudomonas syringae; Sphingosine | 2010 |
The effect of a phytosphingosine-like substance isolated from Asterina pectinifera on involucrin expression in mite antigen-stimulated HaCaT cells.
Topics: Animals; Antigens; Asterina; Cell Line, Tumor; Mites; Protein Precursors; Sphingosine | 2010 |
Regulation of yeast nutrient permease endocytosis by ATP-binding cassette transporters and a seven-transmembrane protein, RSB1.
Topics: Amino Acid Transport Systems; ATP-Binding Cassette Transporters; Biological Transport; Blotting, Western; Cell Membrane; Endocytosis; Green Fluorescent Proteins; Membrane Proteins; Microscopy, Fluorescence; Mutation; Protein Binding; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Sphingosine; Tryptophan | 2010 |
A general and concise asymmetric synthesis of sphingosine, safingol and phytosphingosines via tethered aminohydroxylation.
Topics: Amines; Hydroxylation; Molecular Conformation; Sphingosine | 2010 |
Synthesis of cytotoxic aza analogues of jaspine B.
Topics: Animals; Cell Line, Tumor; Humans; Melanoma, Experimental; Mice; Pyrrolidines; Sphingosine; Stereoisomerism | 2010 |
Regioselective inversion of the hydroxyl group in D-ribo-phytosphingosine via a cyclic sulfate and bis-sulfonate intermediate.
Topics: Alkanesulfonates; Magnetic Resonance Spectroscopy; Molecular Structure; Sphingosine; Stereoisomerism; Sulfates | 2011 |
Investigation of the molecular structure of the human stratum corneum ceramides [NP] and [EOS] by mass spectrometry.
Topics: Ceramides; Chromatography, High Pressure Liquid; Fatty Acids; Humans; Skin; Spectrometry, Mass, Electrospray Ionization; Sphingosine; Tandem Mass Spectrometry | 2011 |
A matter of fat: interaction between nitric oxide and sphingolipid signaling in plant cold response.
Topics: Arabidopsis; Ceramides; Cold Temperature; Metabolic Networks and Pathways; Nitric Oxide; Phosphorylation; Signal Transduction; Sphingolipids; Sphingosine | 2011 |
Extraction and analysis of fumonisins and compounds indicative of fumonisin exposure in plant and mammalian tissues and cultured cells.
Topics: Animals; Cells, Cultured; Chromatography, Liquid; Freeze Drying; Fumonisins; Fusarium; Oxidoreductases; Phosphates; Sphingosine; Tandem Mass Spectrometry; Zea mays | 2011 |
A facile synthesis of D-ribo-C(20)-phytosphingosine and its C2 epimer from D-ribose.
Topics: Molecular Structure; Ribose; Sphingosine; Stereoisomerism | 2011 |
Orally administered glucosylceramide improves the skin barrier function by upregulating genes associated with the tight junction and cornified envelope formation.
Topics: Administration, Oral; Administration, Topical; Animals; Electric Impedance; Epidermal Cells; Epidermis; Epithelial Cells; Gene Expression Profiling; Glucosylceramides; Keratinocytes; Male; Mice; Mice, Hairless; RNA; Sodium Dodecyl Sulfate; Sphingosine; Tight Junctions; Up-Regulation | 2011 |
Phytoceramide and sphingoid bases derived from brewer's yeast Saccharomyces pastorianus activate peroxisome proliferator-activated receptors.
Topics: Animals; Ceramides; Genes, Reporter; Hep G2 Cells; Humans; Hydroxylation; Ligands; Mice; NIH 3T3 Cells; Oxidation-Reduction; Peroxisome Proliferator-Activated Receptors; Protein Isoforms; Recombinant Fusion Proteins; Response Elements; Saccharomyces; Sphingolipids; Sphingosine; Transcriptional Activation | 2011 |
Asymmetric synthesis and cytotoxic activity of isomeric phytosphingosine derivatives.
Topics: Animals; Cell Line, Tumor; Cell Survival; Hydrolysis; Mice; Models, Molecular; Molecular Structure; Sphingosine; Stereoisomerism | 2011 |
Antibacterial activity of sphingoid bases and fatty acids against Gram-positive and Gram-negative bacteria.
Topics: Anti-Bacterial Agents; Gram-Negative Bacteria; Gram-Negative Bacterial Infections; Gram-Positive Bacteria; Gram-Positive Bacterial Infections; Humans; Immunity, Innate; Lauric Acids; Microbial Sensitivity Tests; Mouth; Palmitic Acids; Skin; Species Specificity; Sphingosine | 2012 |
Lipid ingredients in moisturizers can modulate skin responses to UV in barrier-disrupted human skin in vivo.
Topics: Administration, Cutaneous; Adult; Chi-Square Distribution; Cholesterol; Collagen; Cosmetics; Cyclooxygenase 2; Humans; Inflammation Mediators; Interleukin-1beta; Interleukin-6; Linoleic Acid; Lipids; Matrix Metalloproteinase 1; Middle Aged; Molecular Weight; Permeability; Republic of Korea; Risk Assessment; Risk Factors; RNA, Messenger; Skin; Skin Absorption; Sphingosine; Sunburn; Time Factors; Ultraviolet Rays | 2012 |
Metabolic profiling based on LC/MS to evaluate unintended effects of transgenic rice with cry1Ac and sck genes.
Topics: Bacillus thuringiensis Toxins; Bacterial Proteins; Chromatography, High Pressure Liquid; Endotoxins; Gene-Environment Interaction; Hemolysin Proteins; Least-Squares Analysis; Lysophospholipids; Mass Spectrometry; Metabolome; Multivariate Analysis; Oleic Acids; Oryza; Palmitic Acid; Plants, Genetically Modified; Principal Component Analysis; Reproducibility of Results; Seeds; Sphingosine; Transgenes; Tryptophan | 2012 |
Isolation and functional characterisation of the genes encoding Δ(8)-sphingolipid desaturase from Brassica rapa.
Topics: Aluminum; Amino Acid Sequence; Arabidopsis; Biocatalysis; Brassica rapa; Evolution, Molecular; Gene Dosage; Gene Expression Regulation, Plant; Intracellular Space; Molecular Sequence Data; Nicotiana; Oxidoreductases; Plants, Genetically Modified; Promoter Regions, Genetic; Protein Transport; Saccharomyces cerevisiae; Sequence Homology, Nucleic Acid; Sphingosine | 2012 |
Phytosphingosine-1-phosphate is a signaling molecule involved in miconazole resistance in sessile Candida albicans cells.
Topics: Antifungal Agents; Candida albicans; Cell Membrane; Drug Resistance, Fungal; Gene Expression Regulation, Bacterial; Membrane Transport Proteins; Miconazole; Mutation; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Signal Transduction; Sphingosine | 2012 |
Penetration and release studies of positively and negatively charged nanoemulsions--is there a benefit of the positive charge?
Topics: Administration, Cutaneous; Chemistry, Pharmaceutical; Drug Carriers; Drug Compounding; Drug Stability; Emulsifying Agents; Emulsions; Glucocorticoids; Kinetics; Myristic Acid; Nanoparticles; Nanotechnology; Permeability; Prednisolone; Pressure; Skin; Skin Absorption; Solubility; Sphingosine; Surface Properties; Technology, Pharmaceutical | 2012 |
14-3-3-regulated Ca(2+)-dependent protein kinase CPK3 is required for sphingolipid-induced cell death in Arabidopsis.
Topics: 14-3-3 Proteins; Apoptosis; Arabidopsis; Arabidopsis Proteins; Calcium; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; Gene Knockout Techniques; Lanthanum; Phosphorylation; Plants, Genetically Modified; Protein Binding; Sphingosine | 2013 |
Stereoselective synthesis of C18-guggultetrol and C18-phytosphingosine analogues from D-fructose.
Topics: Arachidonate 5-Lipoxygenase; Dose-Response Relationship, Drug; Enzyme Inhibitors; Fatty Alcohols; Fructose; Molecular Structure; Sphingosine; Stereoisomerism; Structure-Activity Relationship | 2012 |
Stabilization of sphingomyelin interactions by interfacial hydroxyls - a study of phytosphingomyelin properties.
Topics: 2-Naphthylamine; Anisotropy; Biophysics; Calorimetry, Differential Scanning; Cholesterol; Cyclodextrins; Dose-Response Relationship, Drug; Hydrogen Bonding; Kinetics; Laurates; Lipid Bilayers; Liposomes; Spectrometry, Fluorescence; Sphingolipids; Sphingomyelins; Sphingosine; Sterols; Temperature; Thermodynamics | 2013 |
Sphingoid bases are taken up by Escherichia coli and Staphylococcus aureus and induce ultrastructural damage.
Topics: Anti-Bacterial Agents; Escherichia coli; Microscopy, Electron, Scanning; Microscopy, Electron, Transmission; Sphingosine; Staphylococcus aureus | 2013 |
Improved high-fat diet-induced glucose intolerance by an oral administration of phytosphingosine.
Topics: Adiponectin; Administration, Oral; Animals; Body Weight; Ceramides; Chemokine CCL2; Diabetes Mellitus, Type 2; Diet, High-Fat; Gene Expression; Glucose; Glucose Intolerance; Glucose Tolerance Test; Intestine, Small; Liver; Mice; Mice, Knockout; Multienzyme Complexes; Oxidoreductases; PPAR gamma; Sphingosine; Tumor Necrosis Factor-alpha | 2013 |
Protein transduction domain-containing microemulsions as cutaneous delivery systems for an anticancer agent.
Topics: Adenosine Triphosphate; Administration, Cutaneous; Animals; Antineoplastic Agents, Phytogenic; ATP Binding Cassette Transporter, Subfamily B, Member 1; Caprylates; Carrier Proteins; Cell-Penetrating Peptides; Emulsions; Glycerides; Paclitaxel; Pharmaceutical Vehicles; Skin; Skin Absorption; Skin Irritancy Tests; Sphingosine; Surface-Active Agents; Swine; Water | 2013 |
Functional characterization of Aspergillus nidulans ypkA, a homologue of the mammalian kinase SGK.
Topics: Acyl Coenzyme A; Aspergillus nidulans; Catalysis; Cell Membrane; Endocytosis; Fungal Proteins; Gene Expression Profiling; Gene Expression Regulation, Fungal; Green Fluorescent Proteins; Immediate-Early Proteins; Multigene Family; Mutation; Phenotype; Protein Serine-Threonine Kinases; Saccharomyces cerevisiae; Sphingolipids; Sphingosine; Spores, Fungal | 2013 |
New long chain bases in lipophosphonoglycan of Acanthamoeba castellanii.
Topics: Acanthamoeba castellanii; Gas Chromatography-Mass Spectrometry; Glycosphingolipids; Isomerism; Oxidation-Reduction; Sphingosine | 2013 |
Cutaneous delivery of α-tocopherol and lipoic acid using microemulsions: influence of composition and charge.
Topics: Administration, Cutaneous; alpha-Tocopherol; Animals; Antioxidants; Chemistry, Pharmaceutical; Emulsions; Glucosides; Hydrogen-Ion Concentration; Oils; Permeability; Skin; Skin Absorption; Sphingosine; Surface-Active Agents; Swine; Thioctic Acid; Water | 2013 |
Preparation of anti-vicinal amino alcohols: asymmetric synthesis of D-erythro-sphinganine, (+)-spisulosine, and D-ribo-phytosphingosine.
Topics: Lipids; Molecular Conformation; Sphingosine | 2013 |
Functional analysis of an ATP-binding cassette transporter protein from Aspergillus fumigatus by heterologous expression in Saccharomyces cerevisiae.
Topics: Antifungal Agents; Aspergillus fumigatus; ATP-Binding Cassette Transporters; Biological Transport; Cloning, Molecular; Drug Resistance, Fungal; Gene Expression Regulation, Fungal; Humans; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Sequence Homology, Amino Acid; Sphingosine | 2013 |
Effects of sphingoid bases on the sphingolipidome in early keratinocyte differentiation.
Topics: Cell Differentiation; Cells, Cultured; Ceramides; Cosmetics; Fatty Acids; Gene Expression Profiling; Gene Expression Regulation; Humans; Keratinocytes; Lipids; Permeability; Skin; Sphingolipids; Sphingosine; Time Factors | 2013 |
Phytosphingosine derivatives ameliorate skin inflammation by inhibiting NF-κB and JAK/STAT signaling in keratinocytes and mice.
Topics: Adult; Animals; Anti-Inflammatory Agents; Apoptosis; Cell Survival; Dermatitis; Humans; Inflammation; Interleukin-23; Janus Kinase 1; Keratinocytes; Leukocytes, Mononuclear; Male; MAP Kinase Signaling System; Mice; NF-kappa B; Psoriasis; Signal Transduction; Skin; Sphingosine; T-Lymphocytes; Tetradecanoylphorbol Acetate | 2014 |
The protein kinase Sch9 is a key regulator of sphingolipid metabolism in Saccharomyces cerevisiae.
Topics: Antifungal Agents; Ceramides; Depsipeptides; Drug Resistance, Fungal; Fatty Acids, Monounsaturated; Gene Expression Regulation, Fungal; Gene Knockout Techniques; Microbial Sensitivity Tests; Microbial Viability; Protein Serine-Threonine Kinases; Protein Transport; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Sphingolipids; Sphingosine; Transcription, Genetic; Type C Phospholipases | 2014 |
Loss of Bcl-2 expression correlates with increasing sensitivity to apoptosis in differentiating ES cells.
Topics: Animals; Apoptosis; Cell Differentiation; Cell Line; Embryonic Stem Cells; Membrane Potential, Mitochondrial; Mice; Mitochondria; Proto-Oncogene Proteins c-bcl-2; Sphingosine; Staurosporine | 2014 |
Protected sphingosine from phytosphingosine as an efficient acceptor in glycosylation reaction.
Topics: Glycosylation; Molecular Structure; Sphingosine | 2014 |
Topical ceramides neither enhance UVB-induced apoptosis in normal human keratinocytes nor affect viability in UVB-irradiated reconstructed human epidermis.
Topics: Administration, Topical; Apoptosis; Caspase 3; Cell Differentiation; Cell Survival; Ceramides; Epidermis; Humans; Keratinocytes; Skin; Sphingosine; Ultraviolet Rays; Water | 2014 |
Mechanistic studies on the intramolecular cyclization of O-tosyl phytosphingosines to jaspines.
Topics: Bridged Bicyclo Compounds, Heterocyclic; Cyclization; Marine Toxins; Models, Molecular; Molecular Structure; Sphingosine | 2014 |
Sphingoid bases inhibit acid-induced demineralization of hydroxyapatite.
Topics: Adsorption; Citric Acid; Dental Pellicle; Diffusion; Durapatite; Edetic Acid; Humans; Hydrogen-Ion Concentration; Materials Testing; Microscopy, Atomic Force; Protective Agents; Protein Kinase C; Sphingolipids; Sphingomyelins; Sphingosine; Surface Properties; Time Factors; Tooth Erosion | 2015 |
First total synthesis of ganglioside DSG-A possessing neuritogenic activity.
Topics: Animals; Gangliosides; Glycosylation; Neurites; PC12 Cells; Rats; Sphingosine | 2014 |
Identification of the phytosphingosine metabolic pathway leading to odd-numbered fatty acids.
Topics: Acetate-CoA Ligase; Amino Acid Sequence; Animals; CHO Cells; Cricetinae; Cricetulus; Fatty Acids; HEK293 Cells; Humans; Lyases; Metabolic Networks and Pathways; Mice; Molecular Sequence Data; Palmitic Acids; Phosphates; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Sphingolipids; Sphingosine | 2014 |
The influence of the acyl chain on the transdermal penetration-enhancing effect of synthetic phytoceramides.
Topics: Aged; Caffeine; Ceramides; Female; Humans; Ibuprofen; In Vitro Techniques; Middle Aged; Molecular Structure; Permeability; Skin; Skin Absorption; Sphingosine; Testosterone | 2015 |
Phytosphingosine promotes megakaryocytic differentiation of myeloid leukemia cells.
Topics: Apoptosis; Cell Cycle Checkpoints; Cell Differentiation; Cell Size; Hematopoiesis; Humans; K562 Cells; Leukemia, Myeloid; Megakaryocytes; p38 Mitogen-Activated Protein Kinases; Platelet Glycoprotein GPIb-IX Complex; Platelet Membrane Glycoprotein IIb; Signal Transduction; Sphingosine | 2015 |
Anti-adherence and bactericidal activity of sphingolipids against Streptococcus mutans.
Topics: Adsorption; Anti-Bacterial Agents; Bacterial Adhesion; Bacteriological Techniques; Biofilms; Dental Pellicle; Dose-Response Relationship, Drug; Durapatite; Humans; Hydrophobic and Hydrophilic Interactions; Microscopy, Atomic Force; Microscopy, Confocal; Sphingolipids; Sphingosine; Streptococcus mutans; Surface Properties | 2015 |
Hypoxia remodels the composition of the constituent ceramide species of HexCer and Hex2Cer with phytosphingosine and hydroxy fatty acids in human colon cancer LS174T cells.
Topics: Caco-2 Cells; Cell Hypoxia; Cell Line, Tumor; Ceramides; Chromatography, Thin Layer; Colonic Neoplasms; Fatty Acids; Glycosphingolipids; Humans; Linear Models; Mass Spectrometry; Oxygen; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Sphingomyelins; Sphingosine; Tandem Mass Spectrometry | 2015 |
Formation and Properties of Membrane-Ordered Domains by Phytoceramide: Role of Sphingoid Base Hydroxylation.
Topics: Ceramides; Hydroxylation; Lipid Bilayers; Molecular Structure; Sphingosine | 2015 |
Metabolites involved in cellular communication among human cumulus-oocyte-complex and sperm during in vitro fertilization.
Topics: Acrosome Reaction; Cell Communication; Cumulus Cells; Female; Fertilization in Vitro; Humans; Lysophosphatidylcholines; Male; Monoglycerides; Oocytes; Sperm Capacitation; Sperm-Ovum Interactions; Spermatozoa; Sphingosine | 2015 |
Substrate specificity, kinetic properties and inhibition by fumonisin B1 of ceramide synthase isoforms from Arabidopsis.
Topics: Acyl Coenzyme A; Arabidopsis; Arabidopsis Proteins; Enzyme Assays; Fumonisins; Hydroxylation; Isoenzymes; Kinetics; Microsomes; Saccharomyces cerevisiae; Sphingosine; Sphingosine N-Acyltransferase; Substrate Specificity | 2016 |
Probing the Role of Ceramide Headgroup Polarity in Short-Chain Model Skin Barrier Lipid Mixtures by ²H Solid-State NMR Spectroscopy.
Topics: Ceramides; Cholesterol; Deuterium; Hydrogen Bonding; Hydrophobic and Hydrophilic Interactions; Macromolecular Substances; Molecular Structure; Organophosphorus Compounds; Proton Magnetic Resonance Spectroscopy; Sphingosine; Stearic Acids; Temperature; Triazoles | 2016 |
Bacillus cereus strain S2 shows high nematicidal activity against Meloidogyne incognita by producing sphingosine.
Topics: Animals; Bacillus cereus; Biological Control Agents; Caenorhabditis elegans; Chromatography, High Pressure Liquid; Chromatography, Liquid; Mass Spectrometry; Reactive Oxygen Species; Solanum lycopersicum; Sphingosine; Tylenchoidea | 2016 |
Anti-erosive effects of fluoride and phytosphingosine: an in vitro study.
Topics: Animals; Cariostatic Agents; Cattle; Fluorides; Sodium Fluoride; Sphingosine; Tin Fluorides; Tooth Erosion; Tooth Remineralization; Toothpastes | 2016 |
Complete structural characterization of ceramides as [M-H]
Topics: Ceramides; Fatty Acids; Ions; Isomerism; Models, Chemical; Molecular Structure; Spectrometry, Mass, Electrospray Ionization; Sphingosine | 2016 |
Accumulation of long-chain bases in yeast promotes their conversion to a long-chain base vinyl ether.
Topics: Acetyl Coenzyme A; Ceramides; Endoplasmic Reticulum; Phosphates; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Serine C-Palmitoyltransferase; Sphingolipids; Sphingosine; Vinyl Compounds | 2016 |
Synthesis of ceramides NS and NP with perdeuterated and specifically ω deuterated N-acyl residues.
Topics: Ceramides; Chemistry Techniques, Synthetic; Deuterium; Sphingosine | 2016 |
Aptamer-based trapping of phytosphingosine in urine samples.
Topics: Aptamers, Nucleotide; Biomarkers; Chromatography, Liquid; Humans; Limit of Detection; Magnets; Spectrometry, Mass, Electrospray Ionization; Sphingosine; Tandem Mass Spectrometry | 2016 |
Inositol Depletion Induced by Acute Treatment of the Bipolar Disorder Drug Valproate Increases Levels of Phytosphingosine.
Topics: Acetyltransferases; Antimanic Agents; Bipolar Disorder; Ceramides; Down-Regulation; Humans; Inositol; Membrane Proteins; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Sphingosine; Up-Regulation; Valproic Acid | 2017 |
Phytosphingosine, sphingosine and dihydrosphingosine ceramides in model skin lipid membranes: permeability and biophysics.
Topics: Biophysics; Cell Membrane Permeability; Ceramides; Hydrogen Bonding; Hydroxylation; Skin; Sphingosine | 2017 |
Phytosphingosine degradation pathway includes fatty acid α-oxidation reactions in the endoplasmic reticulum.
Topics: Aldehyde Oxidoreductases; Animals; CHO Cells; Cricetulus; Endoplasmic Reticulum; HEK293 Cells; HeLa Cells; Humans; Metabolic Networks and Pathways; Oxidation-Reduction; Proteolysis; Sphingosine | 2017 |
Identification of the ligand of Pru p 3, a peach LTP.
Topics: Camptothecin; Carrier Proteins; Flowers; Gene Expression Regulation, Plant; Models, Molecular; Plant Proteins; Pollen; Protein Conformation; Prunus persica; Sphingosine | 2017 |
Three serum metabolite signatures for diagnosing low-grade and high-grade bladder cancer.
Topics: Biomarkers, Tumor; Case-Control Studies; Demography; Female; Humans; Inosine; Kynuramine; Male; Metabolic Networks and Pathways; Metabolomics; Multivariate Analysis; Neoplasm Grading; Principal Component Analysis; Reproducibility of Results; ROC Curve; Sphingosine; Urinary Bladder Neoplasms | 2017 |
Anti-melanogenic activity of phytosphingosine via the modulation of the microphthalmia-associated transcription factor signaling pathway.
Topics: Adult; Cells, Cultured; Cyclic AMP Response Element-Binding Protein; Extracellular Signal-Regulated MAP Kinases; Humans; Melanins; Microphthalmia-Associated Transcription Factor; Middle Aged; Monophenol Monooxygenase; Promoter Regions, Genetic; Signal Transduction; Sphingosine | 2017 |
Non-invasive assessment of culture media from goat cloned embryos associated with subjective morphology by gas chromatography - mass spectroscopy-based metabolomic analysis.
Topics: Amino Acid Transport System ASC; Amino Acid Transport Systems; Amino Acids; Animals; Blastocyst; Cloning, Organism; Culture Media; Embryo Culture Techniques; Embryonic Development; Fusion Regulatory Protein 1, Heavy Chain; Gas Chromatography-Mass Spectrometry; Gene Expression; Glucose; Goats; Metabolomics; Minor Histocompatibility Antigens; Phosphates; Polymerase Chain Reaction; Sphingosine | 2018 |
Phytosphingosine enhances moisture level in human skin barrier through stimulation of the filaggrin biosynthesis and degradation leading to NMF formation.
Topics: Adult; Caspases; Cells, Cultured; Female; Filaggrin Proteins; Healthy Volunteers; Humans; In Vitro Techniques; Intermediate Filament Proteins; Keratinocytes; Male; Metabolic Networks and Pathways; Permeability; Protein Precursors; Pyrrolidonecarboxylic Acid; Skin; Skin Physiological Phenomena; Sphingosine; Transglutaminases; Water; Water Loss, Insensible; Young Adult | 2017 |
Phytosphingosine Prevents the Formation of Young Salivary Biofilms in vitro.
Topics: Adult; Anti-Bacterial Agents; Bacterial Adhesion; Biofilms; Humans; In Vitro Techniques; Male; Saliva; Sphingosine | 2018 |
Phytosphingosine is a novel activator of GPR120.
Topics: Cells, Cultured; Dose-Response Relationship, Drug; HEK293 Cells; Humans; Ligands; Molecular Conformation; Receptors, G-Protein-Coupled; Sphingosine; Structure-Activity Relationship | 2018 |
A rapid synthesis of sphingosine from phytosphingosine.
Topics: Molecular Structure; Sphingosine; Stereoisomerism | 2018 |
Sphingoid Base-Upregulated Caspase-14 Expression Involves MAPK.
Topics: Animals; Caspase 14; Cell Line; Cell Survival; Ceramides; Humans; Keratinocytes; Mice, Inbred ICR; Mitogen-Activated Protein Kinases; Protein Kinase Inhibitors; RNA, Messenger; Skin; Sphingosine; Up-Regulation | 2018 |
Streamlined chemoenzymatic total synthesis of prioritized ganglioside cancer antigens.
Topics: Antigens, Neoplasm; G(M1) Ganglioside; G(M3) Ganglioside; Glycosylation; Lactose; Sphingosine | 2018 |
Novel SWATH
Topics: Adult; Case-Control Studies; Endometriosis; Female; Fertilization in Vitro; Follicular Fluid; Humans; Infertility; Lysophosphatidylcholines; Male; Mass Spectrometry; Metabolomics; Sphingosine | 2018 |
The long periodicity phase (LPP) controversy part I: The influence of a natural-like ratio of the CER[EOS] analogue [EOS]-br in a CER[NP]/[AP] based stratum corneum modelling system: A neutron diffraction study.
Topics: Ceramides; Epidermis; Humans; Lipids; Models, Biological; Nanostructures; Neutron Diffraction; Periodicity; Sphingosine | 2019 |
Synthesis of the cytotoxic phytosphingosines and their isomeric analogues.
Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Chemistry Techniques, Synthetic; Humans; Isomerism; Sphingosine | 2018 |
Metabolic profiling of hypoxia/reoxygenation injury in H9c2 cells reveals the accumulation of phytosphingosine and the vital role of Dan-Shen in Xin-Ke-Shu.
Topics: Animals; Apoptosis; Cell Hypoxia; Cell Survival; Drugs, Chinese Herbal; Metabolomics; Mitochondrial Membrane Transport Proteins; Mitochondrial Permeability Transition Pore; Myocardial Reperfusion Injury; Myocytes, Cardiac; Oxidative Stress; Rats; Salvia miltiorrhiza; Sphingosine | 2018 |
In search of constrained FTY720 and phytosphingosine analogs as dual acting anticancer agents targeting metabolic and epigenetic pathways.
Topics: Animals; Antineoplastic Agents; Cell Proliferation; Cell Survival; Cells, Cultured; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Epigenesis, Genetic; Fingolimod Hydrochloride; Mice; Molecular Structure; Sphingosine; Structure-Activity Relationship | 2018 |
Phytosphingosine Increases Biosynthesis of Phytoceramide by Uniquely Stimulating the Expression of Dihydroceramide C4-desaturase (DES2) in Cultured Human Keratinocytes.
Topics: Cells, Cultured; Ceramides; Humans; Keratinocytes; Oxidoreductases; Real-Time Polymerase Chain Reaction; Sphingosine | 2018 |
A versatile synthesis of αGalCer and its analogues exploiting a cyclic carbonate as phytosphingosine 3,4-diol protecting group.
Topics: Carbonates; Galactosylceramides; Glycosylation; Molecular Structure; Sphingosine; Stereoisomerism | 2019 |
Yeast Mpo1 Is a Novel Dioxygenase That Catalyzes the α-Oxidation of a 2-Hydroxy Fatty Acid in an Fe
Topics: Catalysis; Dioxygenases; Fatty Acids; Iron; Oxidation-Reduction; Palmitic Acids; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Sphingolipids; Sphingosine | 2019 |
The phytosphingosine-CD300b interaction promotes zymosan-induced, nitric oxide-dependent neutrophil recruitment.
Topics: Animals; Arthritis; Dendritic Cells; Inflammation; Lipopolysaccharides; Mice, Inbred C57BL; Mice, Knockout; Neutrophils; Nitric Oxide; Protein Binding; Receptors, Immunologic; Signal Transduction; Sphingosine; Toll-Like Receptor 4; Zymosan | 2019 |
Elevated Levels of Phosphorylated Sphingobases Do Not Antagonize Sphingobase- or Fumonisin B1-Induced Plant Cell Death.
Topics: Cell Death; Fumonisins; Gene Expression Regulation, Plant; Phosphorylation; Sphingolipids; Sphingosine | 2019 |
Probing the interactions among sphingosine and phytosphingosine ceramides with non- and alpha-hydroxylated acyl chains in skin lipid model membranes.
Topics: Ceramides; Hydroxylation; Membrane Lipids; Phase Transition; Skin; Sphingosine; Temperature | 2019 |
New insight into phase behavior and permeability of skin lipid models based on sphingosine and phytosphingosine ceramides.
Topics: Ceramides; Cholesterol; Diffusion; Fatty Acids; Hydrogen Bonding; Membranes, Artificial; Models, Biological; Permeability; Skin; Sphingosine; X-Ray Diffraction | 2019 |
Stress-Induced Changes in the Lipid Microenvironment of β-(1,3)-d-Glucan Synthase Cause Clinically Important Echinocandin Resistance in Aspergillus fumigatus.
Topics: Antifungal Agents; Aspergillosis; Aspergillus fumigatus; Drug Resistance, Fungal; Echinocandins; Fungal Proteins; Glucosyltransferases; Humans; Microbial Sensitivity Tests; Oxidative Stress; Protein Processing, Post-Translational; Reactive Oxygen Species; Sphingosine; Stress, Physiological | 2019 |
Phytosphinganine Affects Plasmodesmata Permeability via Facilitating PDLP5-Stimulated Callose Accumulation in Arabidopsis.
Topics: Arabidopsis; Arabidopsis Proteins; Cell Communication; Cell Death; Glucans; Membrane Proteins; Mutation; Permeability; Plant Immunity; Plasmodesmata; Pseudomonas syringae; Sphingolipids; Sphingosine | 2020 |
Mitochondrial reactive oxygen species-mediated cytotoxicity of intracellularly accumulated dihydrosphingosine in the yeast Saccharomyces cerevisiae.
Topics: 3-Phosphoinositide-Dependent Protein Kinases; Cell Division; Intracellular Space; Mitochondria; Mutation; Reactive Oxygen Species; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Sphingosine; Superoxide Dismutase; Tryptophan | 2020 |
MEDEA-interacting protein LONG-CHAIN BASE KINASE 1 promotes pattern-triggered immunity in Arabidopsis thaliana.
Topics: Arabidopsis; Arabidopsis Proteins; Phosphotransferases; Plant Diseases; Plant Stomata; Sphingosine | 2020 |
Targeted analysis of ceramides and cerebrosides in yellow lupin seeds by reversed-phase liquid chromatography coupled to electrospray ionization and multistage mass spectrometry.
Topics: Ceramides; Cerebrosides; Chromatography, High Pressure Liquid; Chromatography, Reverse-Phase; Fatty Acids; Lupinus; Seeds; Spectrometry, Mass, Electrospray Ionization; Sphingosine | 2020 |
Effect of phytosphingosine on staining resistance and microhardness of tooth enamel.
Topics: Animals; Cattle; Color; Dental Enamel; Humans; Materials Testing; Sphingosine; Staining and Labeling; Surface Properties; Tooth Bleaching | 2021 |
Lipidomics profiling of skin surface lipids in senile pruritus.
Topics: Aged; Ceramides; Chromatography, Liquid; Diglycerides; Female; Humans; Lipidomics; Male; Middle Aged; Phosphatidylcholines; Phosphatidylethanolamines; Pruritus; Skin; Sphingosine; Tandem Mass Spectrometry | 2020 |
A potential pathway for flippase-facilitated glucosylceramide catabolism in plants.
Topics: Glucosylceramidase; Glucosylceramides; Plant Proteins; Plants; Signal Transduction; Sphingolipids; Sphingosine | 2020 |
Engineering Yarrowia lipolytica for de novo production of tetraacetyl phytosphingosine.
Topics: Batch Cell Culture Techniques; Fermentation; Fungal Proteins; Industrial Microbiology; Metabolic Engineering; Recombinant Proteins; Saccharomycetales; Sphingosine; Yarrowia | 2021 |
Enhancing lifespan of budding yeast by pharmacological lowering of amino acid pools.
Topics: Amino Acids; Dose-Response Relationship, Drug; Longevity; Proteins; Saccharomyces cerevisiae; Signal Transduction; Sphingosine | 2021 |
Sphingosine Promotes Embryo Biomass in Upland Cotton: A Biochemical and Transcriptomic Analysis.
Topics: Biomass; Fumonisins; Gene Expression Profiling; Gene Expression Regulation, Plant; Gossypium; Lipid Metabolism; Ovule; Plant Growth Regulators; Sphingolipids; Sphingosine; Transcription Factors; Transcriptome | 2021 |
Identification of Compounds with Potential Therapeutic Uses from Sweet Pepper (
Topics: Capsicum; Carbolines; Chromatography, High Pressure Liquid; Flavin-Adenine Dinucleotide; Fruit; Humans; Mass Spectrometry; Metabolomics; Nitric Oxide; Quercetin; Sphingosine; Tryptophan | 2021 |
Two- and Three-Dimensional Physical-Chemical Characterization of CER[AP]: A Study of Stereochemistry and Chain Symmetry.
Topics: Ceramides; Epidermis; Skin; Sphingosine | 2021 |
The molecular mechanism of phytosphingosine binding to FFAR4/GPR120 differs from that of other fatty acids.
Topics: Cell Communication; Fatty Acids; HEK293 Cells; Humans; Kinetics; Ligands; Molecular Docking Simulation; Protein Binding; Receptors, G-Protein-Coupled; Sphingosine | 2021 |
Push Out Bond Strength of a Glass Fibre Post to Root Dentine Pretreated with Proanthocyanidin and Phytosphingosine - An In Vitro Study.
Topics: Dental Bonding; Dentin; Glass; Gutta-Percha; Humans; Proanthocyanidins; Sphingosine | 2021 |
Design and evaluation of erucic acid-phytosphingosine structured cationic nanoemulsions as a plasmid DNA delivery system against breast cancer cells.
Topics: Breast Neoplasms; Cations; Cell Survival; DNA; Erucic Acids; Female; Humans; Particle Size; Plasmids; Sphingosine; Transfection | 2022 |
The major plant sphingolipid long chain base phytosphingosine inhibits growth of bacterial and fungal plant pathogens.
Topics: Agrobacterium tumefaciens; Antifungal Agents; Arabidopsis; Fungi; Gene Expression; Gene Expression Regulation, Plant; Plant Diseases; Plant Immunity; Plant Leaves; Pseudomonas syringae; Sphingolipids; Sphingosine | 2022 |
Epidemiological observations on pastern dermatitis in young horses and evaluation of essential fatty acid spot-on applications with or without phytosphingosine as prophylactic treatment.
Topics: Animals; Dermatitis; Fatty Acids; Horse Diseases; Horses; Sphingosine | 2022 |
Phytosphingosine ceramide mainly localizes in the central layer of the unique lamellar phase of skin lipid model systems.
Topics: Ceramides; Cholesterol; Epidermis; Fatty Acids, Nonesterified; Humans; Skin; Sphingosine | 2022 |
New Ceramides and Cerebrosides from the Deep-Sea Far Eastern Starfish
Topics: Animals; Ceramides; Cerebrosides; Doxorubicin; Fatty Acids; HEK293 Cells; Humans; Monosaccharides; Sphingolipids; Sphingosine; Starfish | 2022 |
Phytosphingosine-induced cell apoptosis via a mitochondrially mediated pathway.
Topics: Apoptosis; Cytochromes c; Ecosystem; Sphingosine | 2022 |
Multi-omics association analysis reveals interactions between the oropharyngeal microbiome and the metabolome in pediatric patients with influenza A virus pneumonia.
Topics: Child; Chromatography, Liquid; Humans; Influenza A virus; Influenza, Human; Metabolome; Microbiota; Pneumonia; RNA, Ribosomal, 16S; Sphingolipids; Sphingosine; Tandem Mass Spectrometry | 2022 |
Structural diversity of photoswitchable sphingolipids for optodynamic control of lipid microdomains.
Topics: Light; Lipid Bilayers; Membrane Microdomains; Sphingolipids; Sphingosine | 2023 |
Straightforward access to novel cytotoxic phytosphingosine-like aminotriols from l-erythrose chiron.
Topics: Antineoplastic Agents; Sphingosine | 2023 |
Effect of sphingosine and phytosphingosine ceramide ratio on lipid arrangement and barrier function in skin lipid models.
Topics: Ceramides; Epidermis; Humans; Psoriasis; Skin; Sphingosine | 2023 |