phytoestrogens and menatetrenone

Osteoporosis with increased risk of bone fracture is a disabling syndrome that naturally occurs as long as one ages and moves on two legs. Recent progress in bone cell biology has shed light on the mechanisms underlying the anti-osteoporotic properties of drugs that have been in use for a long time, providing a fresh stage for novel pharmacotherapies. In addition, large scale clinical trials developed in the past decade appear not only to rationalize the clinical utilities of these drugs but also to provide new concepts for the development of new therapeutic modalities. Progress in the fields of basic and clinical research field is briefly reviewed herein.

Topics: Alendronate; Androgens; Animals; Binding Sites; Bone Remodeling; Clinical Trials as Topic; Estrogen Replacement Therapy; Estrogens; Estrogens, Non-Steroidal; Evidence-Based Medicine; Humans; Isoflavones; Osteoblasts; Osteoclasts; Osteoporosis; Phytoestrogens; Plant Preparations; Selective Estrogen Receptor Modulators; Vitamin D; Vitamin K 2