phytochlorin and molybdenum-disulfide

Owing to the hypoxia status of the tumor, the reactive oxygen species (ROS) production during photodynamic therapy (PDT) of the tumor is less efficient. Herein, a facile method which involves the synthesis of Mg-Mn-Al layered double hydroxides (LDH) clay with MoS

Topics: Animals; Biomimetic Materials; Catalase; Chlorophyllides; Disulfides; HT29 Cells; Humans; Hydroxides; Magnetic Resonance Imaging; Mice; Molybdenum; Nanostructures; Neoplasms; Photochemotherapy; Photosensitizing Agents; Photothermal Therapy; Porphyrins; Reactive Oxygen Species; Theranostic Nanomedicine

Topics: Animals; Cell Line, Tumor; Cell Survival; Chlorophyllides; Disulfides; Humans; Hyaluronic Acid; Mice; Microscopy, Confocal; Molybdenum; Multimodal Imaging; Nanocomposites; Nanoparticles; Neoplasms; Photochemotherapy; Photosensitizing Agents; Phototherapy; Porphyrins; Quantum Dots; Silicon Dioxide; Singlet Oxygen; Transplantation, Heterologous

Topics: Animals; Body Weight; Cell Survival; Chlorophyllides; Diagnostic Imaging; Disulfides; HeLa Cells; Humans; Infrared Rays; Magnetic Resonance Imaging; Mice, Inbred BALB C; Molybdenum; Nanoparticles; Organ Specificity; Phototherapy; Porphyrins; Silicon Dioxide; Tomography, X-Ray Computed; Tumor Burden; X-Ray Diffraction

MoS2 nanosheets functionalized with poly-ethylene glycol are for the first time used as a multifunctional drug delivery system with high drug loading capacities. Using doxorubicin as the model drug and taking advantages of the strong near-infrared absorbance of MoS2, combined photothermal and chemotherapy of cancer is realized in animal experiments, achieving excellent synergistic anti-tumor effect upon systemic administration.

Topics: Animals; Antineoplastic Agents; Camptothecin; Cell Line, Tumor; Cell Survival; Chlorophyllides; Combined Modality Therapy; Disulfides; Doxorubicin; Drug Carriers; Female; HeLa Cells; Humans; Irinotecan; KB Cells; Mammary Neoplasms, Experimental; Mice; Mice, Inbred BALB C; Molybdenum; Nanostructures; Phototherapy; Pilot Projects; Polyethylene Glycols; Porphyrins; Radiation-Sensitizing Agents

Single- or few-layered transitional metal dichalcogenides, as a new genus of two-dimensional nanomaterials, have attracted tremendous attention in recent years, owing to their various intriguing properties. In this study, chemically exfoliated MoS2 nanosheets are modified with lipoic acid-terminated polyethylene glycol (LA-PEG), obtaining PEGylated MoS2 (MoS2-PEG) with high stability in physiological solutions and no obvious toxicity. Taking advantage of its ultra-high surface area, the obtained MoS2-PEG is able to load a photodynamic agent, chlorin e6 (Ce6), by physical adsorption. In vitro experiments reveal that Ce6 after being loaded on MoS2-PEG shows remarkably increased cellular uptake and thus significantly enhanced photodynamic therapeutic efficiency. Utilizing the strong, near-infrared (NIR) absorbance of the MoS2 nanosheets, we further demonstrate photothermally enhanced photodynamic therapy using Ce6-loaded MoS2-PEG for synergistic cancer killing, in both in vitro cellular and in vivo animal experiments. Our study presents a new type of multifunctional nanocarrier for the delivery of photodynamic therapy, which, if combined with photothermal therapy, appears to be an effective therapeutic approach for cancer treatment.

Topics: Cell Line, Tumor; Cell Survival; Chlorophyllides; Coated Materials, Biocompatible; Combined Modality Therapy; Diffusion; Disulfides; Humans; Light; Metal Nanoparticles; Molybdenum; Nanocapsules; Neoplasms, Experimental; Photochemotherapy; Photosensitizing Agents; Phototherapy; Polyethylene Glycols; Porphyrins; Treatment Outcome