phytochlorin has been researched along with imidazole* in 2 studies
2 other study(ies) available for phytochlorin and imidazole
| Article | Year |
|---|---|
pH-Sensitive Carbon Dots for Enhancing Photomediated Antitumor Immunity.
Recent cancer immunotherapy has attracted much attention due to high specificity and recurrence prevention of tumor. Nevertheless, its therapeutic effects are still challenging in solid cancer. To establish superior antitumor immunity, chlorin e6 (Ce6)-loaded pH sensitive carbon dots were investigated (Ce6@IDCDs). At tumoral pH 6.5, Ce6 was released four times compared with the release at physiological pH 7.4 due to an imbalance between hydrophilic and hydrophobic forces via protonation of imidazole groups in Ce6@IDCDs. This result led to the superior singlet oxygen generating activity of Ce6@IDCDs without Ce6 quenching. The maturation effects of dendritic cells after co-incubation with supernatant media obtained from Ce6@IDCDs with laser-treated cells at pH 6.5 were much higher than at physiological pH. Furthermore, Ce6@IDCDs following a laser at pH 6.5 significantly promoted calreticulin exposure and high-mobility group box 1 release, as major immunogenic cell death markers. In bilateral CT-26-bearing mice model, the Ce6@IDCDs elicited significant antitumoral effects at laser treated-primary tumor regions via therapeutic reactive oxygen species. Furthermore, Ce6@IDCDs upon laser irradiation induced a large amount of activated CD8 Topics: Animals; Calreticulin; Carbon; Cell Death; Cell Line, Tumor; Chlorophyllides; Dendritic Cells; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Imidazoles; Immunotherapy; Lasers; Mice; Mice, Inbred BALB C; Mice, Nude; Microscopy, Electron, Transmission; Nanoparticles; Neoplasms; Particle Size; Photochemotherapy; Porphyrins; Radiation-Sensitizing Agents; Reactive Oxygen Species; Spectroscopy, Fourier Transform Infrared; Tumor Microenvironment; Xenograft Model Antitumor Assays | 2020 |
Singlet oxygen-responsive micelles for enhanced photodynamic therapy.
Photodynamic therapy (PDT) efficacy is limited by the very short half-life and limited diffusion radius of singlet oxygen ( Topics: Animals; Cell Line, Tumor; Chlorophyllides; Drug Carriers; Drug Liberation; Female; Imidazoles; Light; Mice, Inbred BALB C; Micelles; Neoplasms; Photochemotherapy; Photosensitizing Agents; Porphyrins; Singlet Oxygen | 2017 |