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physostigmine heptyl and physostigmine

physostigmine heptyl has been researched along with physostigmine in 70 studies

Research

Studies (70)

Timeframe	Studies, this research(%)	All Research%
pre-1990	3 (4.29)	18.7374
1990's	52 (74.29)	18.2507
2000's	11 (15.71)	29.6817
2010's	2 (2.86)	24.3611
2020's	2 (2.86)	2.80

Authors

Authors	Studies
Chen, YL; Dunaiskis, A; Hedberg, K; Ives, J; Johnson, J; Jones, S; Liston, D; Nielsen, J; Russo, L	1
Chapin, D; Chen, YL; Dunaiskis, A; Hedberg, K; Ives, J; Johnson, J; Jones, S; Liston, D; Nielsen, J	1
Brossi, A; Greig, NH; Holloway, HW; Whittaker, NF; Yu, QS; Zhu, X	1
Alley, GM; Brossi, A; Deschamps, JR; Greig, NH; Holloway, HW; Kulkarni, SS; Lahiri, DK; Luo, W; Parrish, D; Yu, QS; Zhan, M	1
Brossi, A; Greig, NH; Holloway, HW; Kulkarni, SS; Lahiri, DK; Luo, W; Parrish, DA; Shafferman, A; Tweedie, D; Yu, QS	1
Chaudhaery, SS; Nath, C; Nazir, A; Roy, KK; Sammi, SR; Saxena, AK; Saxena, G; Shakya, N	1
Andrisano, V; Bartolini, M; Belluti, F; Bisi, A; Di Marzo, V; Gobbi, S; Ligresti, A; Montanari, S; Mor, M; Rampa, A; Rivara, S; Scalvini, L	1
Li, X; Wang, S; Wang, Y; Wang, Z; Zhang, H	1
Brossi, A; Garofalo, P; Greig, NH; Heller, B; Iijima, S; Ingram, DK; Spangler, EL	1
Constanzer, ML; Herold, ML; Matuszewski, BK	1
Becker, RE; Moriearty, PL	1
Giacobini, E; Messamore, E; Ogane, N	1
Brazell, C; Heald, A; Iversen, SD; Pagella, PG; Rupniak, NM; Tye, SJ	1
Becker, RE; Unni, LK	1
Arnerić, SP; Giacobini, E; Linville, DG	1
Becker, RE; Hutt, V; Imbimbo, BP; Unni, LK	1
De Sarno, P; Giacobini, E; Pomponi, M; Tang, XC; Williams, E	1
Brufani, M; Castellano, C; Marta, M; Oliverio, A; Pagella, PG; Pavone, F; Pomponi, M; Rugarli, PL	1
Brufani, M; Marta, M; Pomponi, M	1
Cuadra, G; Giacobini, E	2
Arison, B; Chen, TS; Cheng, H; Monaghan, R; Petuch, B; Schwartz, MS; So, L; White, R	1
Fusi, F; Giacobini, E; Lai, CC; Mori, F	1
Giustina, A; Imbimbo, BP; Licini, M; Mosca, A; Onelli, E; Schettino, M; Zecca, L	1
Imbimbo, BP; Luzzana, M; Mosca, A; Onelli, E; Paleari, R; Rosti, E	1
Thal, LJ; Waite, JJ	1
Brufani, M; Filocamo, L; Imbriani, E; Lappa, S; Mannina, L	1
Barchowsky, A; Block, GA; Cutler, NR; Reines, SA; Sawin, SF; Sramek, JJ	1
Cuadra, G; Giacobini, E; Summers, K	1
Becker, RE; Latham, G; Martinez, R; Potter, W; Radcliffe, J; Sunderland, T; Unni, LK	1
Dawson, GR; Iversen, SD	1
Giacobini, E; Messamore, E; Warpman, U; Williams, E	1
Bondiolotti, GP; Cattaneo, L; Cocchi, D; Muller, EE	1
Auteri, A; Imbimbo, BP; Lattuada, N; Luzzana, M; Mosca, A; Radice, D; Zecca, L	1
Heuser, D; Hudgell, R; Imbimbo, BP; Romero, E; Scremin, AM; Scremin, OU	1
Cella, SG; Imbimbo, BP; Müller, EE; Pieretti, F	1
Mosca, A; Pagella, PG; Radice, D; Zecca, L	1
Auteri, A; Cazzola, E; Imbimbo, BP; Lattuada, N; Luzzana, M; Mosca, A; Radice, D; Zecca, L	1
Giacobini, E; Messamore, E; Ogane, N; Warpman, U	1
Cutler, NR; Sramek, JJ	2
Giacobini, E; Lai, CC; Mori, F	1
Camacho, F; Smith, CP; Vargas, HM; Winslow, JT	1
Braida, D; Griffini, P; Lamperti, M; Maggi, A; Paladini, E; Sala, M	1
Canal, N; Imbimbo, BP	1
Ghezzi, A; Imbimbo, BP; Luzzana, M; Mosca, A; Paleari, R	1
Hänninen, O; Kaliste-Korhonen, E; Raushel, FM; Tuovinen, K	3
Jenden, DJ; Li, MG; Scremin, AM; Scremin, OU	1
Garrone, B; Landolfi, C; Luparini, MR; Magnani, M; Milanese, C; Tolu, L	1
Bjornsson, TD; Imbimbo, BP; Troetel, WM	1
Imbimbo, BP; Mant, T; Troetel, WM	1
Alberoni, M; Imbimbo, BP; Lucca, U; Lucchelli, F; Thal, LJ	1
Calcagnini, G; Fieschi, C; Frontoni, M; Giubilei, F; Imbimbo, BP; Lino, S; Santini, M; Strano, S; Tisei, P	1
Scheltens, P; Verhey, FR	1
Imbimbo, BP; Lucca, U; Lucchelli, F; Martelli, P; Thal, LJ; Troetel, WM	1
Cross, AJ; De Souza, RJ; Green, AR; Misra, A; Murray, TK; Snape, MF; Williams, JL	1
Loizzo, A; Luzi, M; Palazzesi, S; Pomponi, M; Tebano, MT	1
Hänninen, O; Tuovinen, K	1
Kása, P; Rakonczay, Z; Török, L	1
Braida, D; Ottonello, F; Sala, M; Virag, W	1
Braida, D; Sala, M	2
Braida, D; Ottonello, F; Sala, M	2
Campanella, L; Cocco, R; Favero, G; Sammartino, MP; Tomassetti, M	1
Rakonczay, Z	1
Chapin, D; Hubbard, ST; Jones, SB; Liston, DR; Nason, D; Nielsen, JA; Ramirez, A; Shalaby, IA; Villalobos, A; White, WF	1
Freund, JR; Gopallawa, I; Lee, RJ	1

Reviews

2 review(s) available for physostigmine heptyl and physostigmine

Article	Year
Recent advance on carbamate-based cholinesterase inhibitors as potential multifunctional agents against Alzheimer's disease. European journal of medicinal chemistry, 2022, Oct-05, Volume: 240 Topics: Aged; Alzheimer Disease; Carbamates; Cholinesterase Inhibitors; Humans; Ligands	2022
Eptastigmine: ten years of pharmacology, toxicology, pharmacokinetic, and clinical studies. CNS drug reviews, 2001,Winter, Volume: 7, Issue:4 Topics: Acetylcholine; Acetylcholinesterase; Activities of Daily Living; Agranulocytosis; Alzheimer Disease; Animals; Behavior, Animal; Biogenic Monoamines; Brain; Cholinesterase Inhibitors; Cognition Disorders; Erythrocytes; Humans; Learning; Memory; Physostigmine; Randomized Controlled Trials as Topic	2001

Article

Year

Recent advance on carbamate-based cholinesterase inhibitors as potential multifunctional agents against Alzheimer's disease.

European journal of medicinal chemistry, 2022, Oct-05, Volume: 240

Topics: Aged; Alzheimer Disease; Carbamates; Cholinesterase Inhibitors; Humans; Ligands

2022

Eptastigmine: ten years of pharmacology, toxicology, pharmacokinetic, and clinical studies.

CNS drug reviews, 2001,Winter, Volume: 7, Issue:4

Topics: Acetylcholine; Acetylcholinesterase; Activities of Daily Living; Agranulocytosis; Alzheimer Disease; Animals; Behavior, Animal; Biogenic Monoamines; Brain; Cholinesterase Inhibitors; Cognition Disorders; Erythrocytes; Humans; Learning; Memory; Physostigmine; Randomized Controlled Trials as Topic

2001

Trials

9 trial(s) available for physostigmine heptyl and physostigmine

Article	Year
Relationship between pharmacokinetics and pharmacodynamics of eptastigmine in young healthy volunteers. Journal of clinical pharmacology, 1995, Volume: 35, Issue:3 Topics: Adult; Cholinesterase Inhibitors; Cholinesterases; Chromatography, High Pressure Liquid; Cross-Over Studies; Double-Blind Method; Erythrocytes; Humans; Male; Physostigmine	1995
A patient-side technique for real-time measurement of acetylcholinesterase activity during monitoring of eptastigmine treatment. Therapeutic drug monitoring, 1995, Volume: 17, Issue:3 Topics: Acetylcholinesterase; Adolescent; Adult; Alzheimer Disease; Cholinesterase Inhibitors; Double-Blind Method; Drug Monitoring; Female; Humans; Hydrogen-Ion Concentration; Male; Middle Aged; Physostigmine; Reproducibility of Results	1995
A multiple-dose safety trial of eptastigmine in Alzheimer's disease, with pharmacodynamic observations of red blood cell cholinesterase. Life sciences, 1995, Volume: 56, Issue:5 Topics: Acetylcholinesterase; Aged; Aged, 80 and over; Alzheimer Disease; Butyrylcholinesterase; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Double-Blind Method; Drug Administration Schedule; Erythrocytes; Female; Humans; Male; Middle Aged; Physostigmine; Placebos	1995
The target population in phase I clinical trials of cholinergic compounds in Alzheimer disease: the role of the "bridging study". Alzheimer disease and associated disorders, 1995,Fall, Volume: 9, Issue:3 Topics: Alzheimer Disease; Cholinergic Agents; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Drug Tolerance; Humans; Physostigmine; Safety; Tacrine	1995
Relationship between pharmacodynamic activity and cognitive effects of eptastigmine in patients with Alzheimer's disease. Eptastigmine Study Group. Clinical pharmacology and therapeutics, 1996, Volume: 60, Issue:2 Topics: Aged; Aged, 80 and over; Alzheimer Disease; Cholinesterase Inhibitors; Cognition; Double-Blind Method; Drug Administration Schedule; Erythrocytes; Female; Humans; Male; Middle Aged; Physostigmine	1996
Effect of food on the absorption of eptastigmine. European journal of clinical pharmacology, 1998, Volume: 54, Issue:3 Topics: Acetylcholinesterase; Administration, Oral; Adolescent; Adult; Area Under Curve; Butyrylcholinesterase; Cholinesterase Inhibitors; Cross-Over Studies; Dizziness; Double-Blind Method; Food; Headache; Humans; Male; Physostigmine; Treatment Outcome	1998
Maximum tolerated dose and pharmacodynamics of eptastigmine in elderly healthy volunteers. Journal of clinical pharmacology, 1998, Volume: 38, Issue:7 Topics: Aged; Aged, 80 and over; Cholinesterase Inhibitors; Cross-Over Studies; Dose-Response Relationship, Drug; Double-Blind Method; Female; Humans; Male; Physostigmine	1998
A 25-week placebo-controlled study of eptastigmine in patients with Alzheimer disease. Alzheimer disease and associated disorders, 1998, Volume: 12, Issue:4 Topics: Aged; Aged, 80 and over; Alzheimer Disease; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Double-Blind Method; Drug Administration Schedule; Female; Humans; Male; Mental Status Schedule; Middle Aged; Neuropsychological Tests; Physostigmine; Treatment Outcome	1998
Efficacy and safety of eptastigmine for the treatment of patients with Alzheimer's disease. Neurology, 1999, Mar-10, Volume: 52, Issue:4 Topics: Aged; Aged, 80 and over; Alzheimer Disease; Cholinesterase Inhibitors; Double-Blind Method; Female; Humans; Male; Middle Aged; Physostigmine; Treatment Outcome	1999

Other Studies

59 other study(ies) available for physostigmine heptyl and physostigmine

Article	Year
Syntheses, resolution, and structure-activity relationships of potent acetylcholinesterase inhibitors: 8-carbaphysostigmine analogues. Journal of medicinal chemistry, 1992, Apr-17, Volume: 35, Issue:8 Topics: Animals; Brain; Cholinesterase Inhibitors; Lethal Dose 50; Male; Mice; Physostigmine; Structure-Activity Relationship	1992
Syntheses and anticholinesterase activity of tetrahydrobenzazepine carbamates. Journal of medicinal chemistry, 1994, Jun-24, Volume: 37, Issue:13 Topics: Administration, Oral; Amnesia; Animals; Avoidance Learning; Benzazepines; Carbamates; Cholinesterase Inhibitors; Cholinesterases; Dose-Response Relationship, Drug; Injections, Intraperitoneal; Magnetic Resonance Spectroscopy; Male; Mice	1994
Anticholinesterase activity of compounds related to geneserine tautomers. N-Oxides and 1,2-oxazines. Journal of medicinal chemistry, 2002, Aug-15, Volume: 45, Issue:17 Topics: Acetylcholinesterase; Alkaloids; Butyrylcholinesterase; Cholinesterase Inhibitors; Cyclic N-Oxides; Humans; Isomerism; Oxazines; Structure-Activity Relationship	2002
Novel anticholinesterases based on the molecular skeletons of furobenzofuran and methanobenzodioxepine. Journal of medicinal chemistry, 2005, Feb-24, Volume: 48, Issue:4 Topics: Acetylcholinesterase; Amyloid beta-Protein Precursor; Benzofurans; Butyrylcholinesterase; Carbamates; Cell Line; Cell Survival; Cholinesterase Inhibitors; Crystallography, X-Ray; Humans; Models, Molecular; Molecular Structure; Neurons; Oxepins; Structure-Activity Relationship	2005
Inhibition of human acetyl- and butyrylcholinesterase by novel carbamates of (-)- and (+)-tetrahydrofurobenzofuran and methanobenzodioxepine. Journal of medicinal chemistry, 2006, Apr-06, Volume: 49, Issue:7 Topics: Acetophenones; Acetylcholinesterase; Animals; Benzofurans; Butyrylcholinesterase; Carbamates; Cholinesterase Inhibitors; Crystallography, X-Ray; Furans; Heterocyclic Compounds, 3-Ring; Humans; Models, Molecular; Oxepins; Stereoisomerism; Structure-Activity Relationship; Torpedo	2006
Novel carbamates as orally active acetylcholinesterase inhibitors found to improve scopolamine-induced cognition impairment: pharmacophore-based virtual screening, synthesis, and pharmacology. Journal of medicinal chemistry, 2010, Sep-09, Volume: 53, Issue:17 Topics: Acetylcholinesterase; Administration, Oral; Animals; Avoidance Learning; Caenorhabditis elegans; Carbamates; Catalytic Domain; Cholinesterase Inhibitors; Databases, Factual; Hydrogen Bonding; Hydrophobic and Hydrophilic Interactions; Male; Mice; Models, Molecular; Nootropic Agents; Quantitative Structure-Activity Relationship; Scopolamine	2010
Fatty Acid Amide Hydrolase (FAAH), Acetylcholinesterase (AChE), and Butyrylcholinesterase (BuChE): Networked Targets for the Development of Carbamates as Potential Anti-Alzheimer's Disease Agents. Journal of medicinal chemistry, 2016, 07-14, Volume: 59, Issue:13 Topics: Acetylcholinesterase; Alzheimer Disease; Amidohydrolases; Butyrylcholinesterase; Carbamates; Cell Line, Tumor; Dose-Response Relationship, Drug; Enzyme Inhibitors; Humans; Models, Molecular; Molecular Structure; Structure-Activity Relationship	2016
The long-acting cholinesterase inhibitor heptyl-physostigmine attenuates the scopolamine-induced learning impairment of rats in a 14-unit T-maze. Neuroscience letters, 1992, Sep-14, Volume: 144, Issue:1-2 Topics: Acetylcholinesterase; Animals; Cholinesterase Inhibitors; Electroshock; Erythrocytes; Learning; Male; Physostigmine; Rats; Rats, Inbred F344; Scopolamine	1992
Determination of picogram levels of heptylphysostigmine in human plasma using high-performance liquid chromatography with fluorescence detection. Journal of chromatography, 1992, Oct-23, Volume: 581, Issue:2 Topics: Cholinesterase Inhibitors; Chromatography, High Pressure Liquid; Electrochemistry; Humans; Physostigmine; Reproducibility of Results; Spectrometry, Fluorescence	1992
Inhibition of human brain and RBC acetylcholinesterase (AChE) by heptylphysostigmine (HPTL). Methods and findings in experimental and clinical pharmacology, 1992, Volume: 14, Issue:8 Topics: Acetylcholinesterase; Brain; Cholinesterase Inhibitors; Cholinesterase Reactivators; Dichlorvos; Erythrocytes; Humans; Hydrogen-Ion Concentration; Physostigmine; Pralidoxime Compounds	1992
Preferential inhibition of acetylcholinesterase molecular forms in rat brain. Neurochemical research, 1992, Volume: 17, Issue:5 Topics: Acetylcholinesterase; Animals; Brain; Centrifugation, Density Gradient; Cholinesterase Inhibitors; Detergents; Isoflurophate; Macromolecular Substances; Male; Neostigmine; Octoxynol; Physostigmine; Polyethylene Glycols; Rats; Rats, Inbred Strains; Solubility; Water	1992
Reversal of cognitive impairment by heptyl physostigmine, a long-lasting cholinesterase inhibitor, in primates. Journal of the neurological sciences, 1992, Volume: 107, Issue:2 Topics: Acetylcholinesterase; Analysis of Variance; Animals; Body Temperature Regulation; Cholinesterase Inhibitors; Cognition; Dose-Response Relationship, Drug; Erythrocyte Membrane; Macaca mulatta; Male; Memory; Physostigmine; Reference Values; Saimiri; Scopolamine; Time Factors	1992
Determination of heptylphysostigmine in plasma by high-performance liquid chromatography with electrochemical detection. Journal of chromatography, 1992, Jan-17, Volume: 573, Issue:2 Topics: Cholinesterase Inhibitors; Cholinesterases; Chromatography, High Pressure Liquid; Electrochemistry; Humans; Physostigmine	1992
Heptyl-physostigmine enhances basal forebrain control of cortical cerebral blood flow. Journal of neuroscience research, 1992, Volume: 31, Issue:3 Topics: Animals; Cerebral Cortex; Cerebrovascular Circulation; Cholinesterase Inhibitors; Electric Stimulation; Male; Parasympathetic Nervous System; Physostigmine; Prosencephalon; Rats; Rats, Inbred Strains; Stimulation, Chemical	1992
Kinetics of cholinesterase inhibition by eptastigmine in man. European journal of clinical pharmacology, 1991, Volume: 41, Issue:1 Topics: Adult; Alzheimer Disease; Cholinesterase Inhibitors; Humans; Kinetics; Male; Physostigmine	1991
The effect of heptyl-physostigmine, a new cholinesterase inhibitor, on the central cholinergic system of the rat. Neurochemical research, 1989, Volume: 14, Issue:10 Topics: Acetylcholinesterase; Animals; Cholinergic Fibers; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Erythrocytes; Male; Physostigmine; Rats; Rats, Inbred Strains	1989
A long-lasting cholinesterase inhibitor affecting neural and behavioral processes. Pharmacology, biochemistry, and behavior, 1987, Volume: 26, Issue:3 Topics: Acetylcholinesterase; Animals; Avoidance Learning; Behavior, Animal; Brain; Cerebral Cortex; Exploratory Behavior; Kinetics; Male; Mice; Mice, Inbred DBA; Physostigmine; Rats; Rats, Inbred Strains; Reaction Time	1987
Anticholinesterase activity of a new carbamate, heptylphysostigmine, in view of its use in patients with Alzheimer-type dementia. European journal of biochemistry, 1986, May-15, Volume: 157, Issue:1 Topics: Acetylcholinesterase; Alzheimer Disease; Animals; Cholinesterase Inhibitors; Eels; In Vitro Techniques; Kinetics; Mathematics; Physostigmine	1986
Effects of cholinesterase inhibitors and clonidine coadministration on rat cortex neurotransmitters in vivo. The Journal of pharmacology and experimental therapeutics, 1995, Volume: 275, Issue:1 Topics: Acetylcholine; Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-Agonists; Animals; Cerebral Cortex; Cholinesterase Inhibitors; Clonidine; Dialysis; Dopamine; Drug Interactions; Male; Neurotransmitter Agents; Norepinephrine; Physostigmine; Rats; Rats, Sprague-Dawley; Serotonin	1995
Microbial transformation of N-heptyl physostigmine, a semisynthetic alkaloid inhibitor of cholinesterase. Journal of industrial microbiology, 1995, Volume: 15, Issue:2 Topics: Acremonium; Biotransformation; Cholinesterase Inhibitors; Mitosporic Fungi; Physostigmine	1995
Cholinesterase inhibitors increase secretion of APPs in rat brain cortex. Neuroreport, 1995, Mar-07, Volume: 6, Issue:4 Topics: Amyloid beta-Protein Precursor; Analysis of Variance; Animals; Bethanechol; Cerebral Cortex; Cholinesterase Inhibitors; Dichlorvos; Electric Stimulation; In Vitro Techniques; Male; Physostigmine; Rats; Rats, Sprague-Dawley	1995
Coadministration of cholinesterase inhibitors and idazoxan: effects of neurotransmitters in rat cortex in vivo. The Journal of pharmacology and experimental therapeutics, 1995, Volume: 273, Issue:1 Topics: Acetylcholine; Adrenergic alpha-Antagonists; Animals; Cerebral Cortex; Cholinesterase Inhibitors; Dioxanes; Dopamine; Drug Synergism; Idazoxan; Male; Microdialysis; Neurotransmitter Agents; Norepinephrine; Physostigmine; Rats; Rats, Sprague-Dawley; Serotonin	1995
The behavioral effects of heptylphysostigmine on rats lesioned in the nucleus basalis. Neuroscience research, 1995, Volume: 21, Issue:3 Topics: Acetylcholinesterase; Acoustic Stimulation; Animals; Basal Ganglia; Behavior, Animal; Brain; Choline O-Acetyltransferase; Cholinesterase Inhibitors; Exploratory Behavior; Learning; Male; Maze Learning; Memory; Motor Activity; Physostigmine; Psychomotor Performance; Rats; Rats, Inbred F344; Rats, Sprague-Dawley; Reflex, Startle; Space Perception	1995
Synthesis of 2'-heptylcarbamoyloxy-2-methyl-6,7-benzomorphan: a new analogue of heptylphysostigmine (MF 201). Farmaco (Societa chimica italiana : 1989), 1994, Volume: 40, Issue:11 Topics: Benzomorphans; Cholinesterase Inhibitors; Physostigmine	1994
Cholinesterase inhibitor effects on neurotransmitters in rat cortex in vivo. The Journal of pharmacology and experimental therapeutics, 1994, Volume: 270, Issue:1 Topics: Acetylcholine; Animals; Cerebral Cortex; Cholinesterase Inhibitors; Dialysis; Dopamine; Dose-Response Relationship, Drug; Extracellular Space; Injections, Subcutaneous; Male; Neurotransmitter Agents; Norepinephrine; Perfusion; Physostigmine; Rats; Rats, Sprague-Dawley; Serotonin; Sodium Chloride	1994
Oral administration of heptylphysostigmine in healthy volunteers: a preliminary study. Methods and findings in experimental and clinical pharmacology, 1994, Volume: 16, Issue:5 Topics: Administration, Oral; Adolescent; Adult; Cholinesterase Inhibitors; Cholinesterases; Drug Administration Schedule; Erythrocytes; Half-Life; Humans; Male; Physostigmine	1994
The effects of novel cholinesterase inhibitors and selective muscarinic receptor agonists in tests of reference and working memory. Behavioural brain research, 1993, Nov-30, Volume: 57, Issue:2 Topics: Animals; Avoidance Learning; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Cholinesterase Inhibitors; Conditioning, Classical; Discrimination Learning; Donepezil; Dose-Response Relationship, Drug; Indans; Learning; Memory; Mice; Oxadiazoles; Pain Threshold; Parasympathomimetics; Physostigmine; Piperidines; Pyrazines; Quinuclidines; Rats; Receptors, Muscarinic; Thiophenes	1993
Muscarinic receptors mediate attenuation of extracellular acetylcholine levels in rat cerebral cortex after cholinesterase inhibition. Neuroscience letters, 1993, Aug-20, Volume: 158, Issue:2 Topics: Acetylcholine; Animals; Atropine; Cerebral Cortex; Cholinesterase Inhibitors; Dialysis; Extracellular Space; Male; Physostigmine; Rats; Rats, Sprague-Dawley; Receptors, Muscarinic	1993
Effect of acute and short-term administration of cholinomimetic drugs on corticosterone secretion in the rat. European journal of pharmacology, 1993, Sep-14, Volume: 241, Issue:2-3 Topics: Analysis of Variance; Animals; Cholinesterase Inhibitors; Cholinesterases; Corticosterone; Glycerylphosphorylcholine; Hypothalamo-Hypophyseal System; Male; Oximes; Parasympathomimetics; Physostigmine; Pituitary-Adrenal System; Pyridines; Radioimmunoassay; Rats; Rats, Inbred WKY	1993
Pharmacodynamics and pharmacokinetics of eptastigmine in elderly subjects. European journal of clinical pharmacology, 1993, Volume: 45, Issue:4 Topics: Administration, Oral; Aged; Aged, 80 and over; Cholinesterase Inhibitors; Cholinesterases; Erythrocytes; Female; Half-Life; Humans; Male; Middle Aged; Physostigmine	1993
Prolonged effects of cholinesterase inhibition with eptastigmine on the cerebral blood flow-metabolism ratio of normal rats. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 1993, Volume: 13, Issue:4 Topics: Animals; Brain; Cerebrovascular Circulation; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Glucose; Male; Physostigmine; Rats; Rats, Wistar; Reference Values; Regression Analysis; Time Factors	1993
Eptastigmine augments basal and GHRH-stimulated growth hormone release in young and old dogs. Life sciences, 1993, Volume: 53, Issue:5 Topics: Aging; Animals; Cholinesterase Inhibitors; Cholinesterases; Dogs; Dose-Response Relationship, Drug; Female; Growth Hormone; Male; Physostigmine	1993
Determination of heptylphysostigmine in plasma by high-performance liquid chromatography with electrochemical detection. Journal of chromatography, 1993, May-19, Volume: 615, Issue:1 Topics: Acetylcholinesterase; Cholinesterase Inhibitors; Chromatography, High Pressure Liquid; Electrochemistry; Erythrocytes; Humans; Physostigmine	1993
Rapid potentiometric determination of cholinesterases in plasma and red cells: application to eptastigmine monitoring. Chemico-biological interactions, 1993, Volume: 87, Issue:1-3 Topics: Administration, Oral; Aged; Aged, 80 and over; Cholinesterase Inhibitors; Cholinesterases; Drug Monitoring; Erythrocytes; Humans; Hydrogen-Ion Concentration; Middle Aged; Physostigmine; Potentiometry	1993
Cholinesterase inhibitor effects on extracellular acetylcholine in rat cortex. Neuropharmacology, 1993, Volume: 32, Issue:8 Topics: Acetylcholine; Animals; Cerebral Cortex; Cholinesterase Inhibitors; Chromatography, High Pressure Liquid; Dialysis; Electrochemistry; Extracellular Space; Male; Physostigmine; Rats; Rats, Sprague-Dawley; Tacrine	1993
Scientific and ethical concerns in clinical trials in Alzheimer's patients: the bridging study. European journal of clinical pharmacology, 1995, Volume: 48, Issue:6 Topics: Alzheimer Disease; Cholinesterase Inhibitors; Clinical Trials as Topic; Dihydropyridines; Ethics, Medical; Humans; Nootropic Agents; Oximes; Physostigmine; Psychotropic Drugs; Pyridines; Tacrine; Thiadiazoles	1995
The effect of cholinesterase inhibitors on the secretion of APPS from rat brain cortex. Annals of the New York Academy of Sciences, 1996, Jan-17, Volume: 777 Topics: Amyloid beta-Protein Precursor; Animals; Bethanechol; Cerebral Cortex; Cholinesterase Inhibitors; Dichlorvos; Electric Stimulation; In Vitro Techniques; Physostigmine; Rats; Solubility	1996
Alpha 2-adrenoceptor antagonists potentiate acetylcholinesterase inhibitor effects on passive avoidance learning in the rat. Psychopharmacology, 1996, Volume: 124, Issue:4 Topics: Adrenergic alpha-Antagonists; Animals; Avoidance Learning; Benzazepines; Cholinesterase Inhibitors; Drug Synergism; Galantamine; Idazoxan; Male; Physostigmine; Rats; Rats, Sprague-Dawley; Tacrine; Yohimbine	1996
An inverted U-shaped curve for heptylphysostigmine on radial maze performance in rats: comparison with other cholinesterase inhibitors. European journal of pharmacology, 1996, Apr-29, Volume: 302, Issue:1-3 Topics: Amnesia; Analysis of Variance; Animals; Behavior, Animal; Cholinesterase Inhibitors; Donepezil; Dose-Response Relationship, Drug; Indans; Male; Maze Learning; Motor Activity; Muscarinic Antagonists; Physostigmine; Piperidines; Rats; Rats, Wistar; Scopolamine; Tacrine	1996
Pharmacodynamic monitoring of eptastigmine in capillary blood. European journal of clinical pharmacology, 1996, Volume: 50, Issue:5 Topics: Acetylcholinesterase; Adult; Alzheimer Disease; Butyrylcholinesterase; Cholinesterase Inhibitors; Humans; Male; Middle Aged; Physostigmine; Time Factors	1996
Eptastigmine-phosphotriesterase combination in DFP intoxication. Toxicology and applied pharmacology, 1996, Volume: 140, Issue:2 Topics: Animals; Antidotes; Aryldialkylphosphatase; Behavior, Animal; Cholinesterase Inhibitors; Drug Therapy, Combination; Esterases; Isoflurophate; Male; Mice; Mice, Inbred Strains; Physostigmine	1996
Phosphotriesterase, pralidoxime-2-chloride (2-PAM) and eptastigmine treatments and their combinations in DFP intoxication. Toxicology and applied pharmacology, 1996, Volume: 141, Issue:2 Topics: Animals; Antidotes; Aryldialkylphosphatase; Brain; Cholinesterase Inhibitors; Esterases; Isoflurophate; Male; Mice; Physostigmine; Pralidoxime Compounds	1996
Cholinesterase inhibition improves blood flow in the ischemic cerebral cortex. Brain research bulletin, 1997, Volume: 42, Issue:1 Topics: Animals; Cerebral Cortex; Cholinesterase Inhibitors; Ischemia; Male; Physostigmine; Rats; Rats, Sprague-Dawley; Regional Blood Flow	1997
Effect of the subchronic treatment with the acetylcholinesterase inhibitor heptastigmine on central cholinergic transmission and memory impairment in aged rats. Neuroscience letters, 1998, Mar-27, Volume: 245, Issue:1 Topics: Acetylcholinesterase; Aging; Animals; Behavior, Animal; Brain; Cholinesterase Inhibitors; Cognition; Male; Memory Disorders; Parasympathetic Nervous System; Physostigmine; Rats; Rats, Wistar; Space Perception; Synaptic Transmission	1998
Cardiac autonomic dysfunction in patients with Alzheimer disease: possible pathogenetic mechanisms. Alzheimer disease and associated disorders, 1998, Volume: 12, Issue:4 Topics: Acetylcholinesterase; Aged; Alzheimer Disease; Autonomic Nervous System; Autonomic Nervous System Diseases; Cholinesterase Inhibitors; Electrocardiography; Erythrocytes; Female; Fourier Analysis; Heart; Heart Rate; Humans; Male; Middle Aged; Physostigmine; Signal Processing, Computer-Assisted	1998
[Drugs for Alzheimer disease: what will the minister decide]. Tijdschrift voor gerontologie en geriatrie, 1998, Volume: 29, Issue:6 Topics: Activities of Daily Living; Aged; Alzheimer Disease; Cholinesterase Inhibitors; Drug Approval; Female; Health Policy; Humans; Male; Middle Aged; Netherlands; Neurobehavioral Manifestations; Physostigmine; Religion and Medicine	1998
A comparative study in rats of the in vitro and in vivo pharmacology of the acetylcholinesterase inhibitors tacrine, donepezil and NXX-066. Neuropharmacology, 1999, Volume: 38, Issue:1 Topics: Acetylcholinesterase; Animals; Butyrylcholinesterase; Carbachol; Cholinesterase Inhibitors; Donepezil; Drug Evaluation, Preclinical; Humans; Indans; Indoles; Injections, Intraperitoneal; Isoquinolines; Logistic Models; Male; Physostigmine; Piperidines; Rats; Structure-Activity Relationship; Tacrine; Tumor Cells, Cultured	1999
Success of pyridostigmine, physostigmine, eptastigmine and phosphotriesterase treatments in acute sarin intoxication. Toxicology, 1999, Jun-15, Volume: 134, Issue:2-3 Topics: Animals; Antidotes; Aryldialkylphosphatase; Esterases; Lethal Dose 50; Male; Mice; Physostigmine; Pyridostigmine Bromide; Sarin	1999
Effects of cholinergic drugs on neocortical EEG and flash-visual evoked potentials in the mouse. Neuropsychobiology, 1999, Volume: 40, Issue:1 Topics: Animals; Cholinesterase Inhibitors; Electroencephalography; Evoked Potentials, Visual; Fourier Analysis; Male; Mice; Mice, Inbred DBA; Neocortex; Physostigmine	1999
Protection of mice against soman by pretreatment with eptastigmine and physostigmine. Toxicology, 1999, Dec-06, Volume: 139, Issue:3 Topics: Animals; Atropine; Blood-Brain Barrier; Brain; Cerebellum; Cholinesterase Inhibitors; Convulsants; Lethal Dose 50; Lung; Male; Mice; Mice, Inbred BALB C; Mice, Inbred DBA; Physostigmine; Soman	1999
Preferential inhibition of acetylcholinesterase molecular forms in normal human brain. Neurobiology (Budapest, Hungary), 1999, Volume: 7, Issue:1 Topics: Acetylcholinesterase; Benzazepines; Brain; Cholinesterase Inhibitors; Humans; Physostigmine; Tacrine	1999
Excitatory and inhibitory effects of second-generation cholinesterase inhibitors on rat gastrointestinal transit. Pharmacological research, 2000, Volume: 41, Issue:6 Topics: Administration, Oral; Animals; Cholinesterase Inhibitors; Donepezil; Dose-Response Relationship, Drug; Gastrointestinal Transit; Hydrocarbons, Brominated; Indans; Male; Physostigmine; Piperidines; Pirenzepine; Rats; Rats, Wistar; Receptor, Muscarinic M1; Receptors, Muscarinic; Receptors, Nicotinic; Scopolamine; Tacrine	2000
Cannabinoid-induced working memory impairment is reversed by a second generation cholinesterase inhibitor in rats. Neuroreport, 2000, Jun-26, Volume: 11, Issue:9 Topics: Animals; Behavior, Animal; Cannabinoids; Cholinesterase Inhibitors; Cyclohexanols; Male; Maze Learning; Memory; Memory Disorders; Motor Activity; Physostigmine; Piperidines; Pyrazoles; Rats; Rats, Wistar; Rimonabant	2000
Eptastigmine improves eight-arm radial maze performance in aged rats. Pharmacological research, 2000, Volume: 42, Issue:4 Topics: Animals; Cholinesterase Inhibitors; Male; Maze Learning; Motor Activity; Physostigmine; Rats; Rats, Wistar	2000
Eptastigmine restores the aged rat's normal cortical spectral power pattern. Pharmacological research, 2000, Volume: 42, Issue:5 Topics: Administration, Oral; Aging; Animals; Cholinesterase Inhibitors; Electroencephalography; Male; Motor Activity; Physostigmine; Rats; Rats, Wistar	2000
Eptastigmine, nicotinamide and nicotinic acid determination using an inhibition enzyme sensor; application to pharmaceutical analysis. Annali di chimica, 2002, Volume: 92, Issue:4 Topics: Biological Assay; Cholinesterase Inhibitors; Niacin; Niacinamide; Pharmaceutical Preparations; Physostigmine; Vasodilator Agents	2002
Potencies and selectivities of inhibitors of acetylcholinesterase and its molecular forms in normal and Alzheimer's disease brain. Acta biologica Hungarica, 2003, Volume: 54, Issue:2 Topics: Acetylcholinesterase; Alzheimer Disease; Benzazepines; Brain; Butyrylcholinesterase; Carbamates; Cerebral Cortex; Cholinesterase Inhibitors; Edrophonium; Humans; In Vitro Techniques; Phenylcarbamates; Physostigmine; Rivastigmine; Tacrine; Trichlorfon	2003
Pharmacology of selective acetylcholinesterase inhibitors: implications for use in Alzheimer's disease. European journal of pharmacology, 2004, Feb-13, Volume: 486, Issue:1 Topics: Acetylcholine; Alzheimer Disease; Animals; Brain; Butyrylcholinesterase; Cholinesterase Inhibitors; Donepezil; Dose-Response Relationship, Drug; Humans; Indans; Male; Mice; Physostigmine; Piperidines; Rats; Rats, Sprague-Dawley; Tacrine	2004
Bitter taste receptors stimulate phagocytosis in human macrophages through calcium, nitric oxide, and cyclic-GMP signaling. Cellular and molecular life sciences : CMLS, 2021, Volume: 78, Issue:1 Topics: Calcium; Cell Communication; Cells, Cultured; Coculture Techniques; Cyclic GMP; Epithelial Cells; Humans; Macrophages; Monocytes; Nitric Oxide; Nitric Oxide Synthase Type III; Pertussis Toxin; Phagocytosis; Physostigmine; Quinolones; Receptors, G-Protein-Coupled; Signal Transduction	2021