phyllanthin and lucifer-yellow

This study investigated the absorptive potential of phyllanthin across the polarized Caco-2 monolayers and the potential role of phyllanthin in P-glycoprotein (P-gp)-mediated drug interaction.. The absorptive potential of phyllanthin was predicted from its apparent permeability (P. Phyllanthin is a highly permeable compound that could passively diffuse through the absorptive barrier via transcellular pathway with little hindrance from P-gp. Phyllanthin could interfere with transport of P-gp drug substrates, when concomitantly administered. In addition, aqueous solubility could be a limiting factor in phyllanthin absorption.

Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Caco-2 Cells; Dose-Response Relationship, Drug; Herb-Drug Interactions; Humans; Hydrogen-Ion Concentration; Intestinal Absorption; Isoquinolines; Lignans; Permeability; Rhodamine 123; Solubility