Page last updated: 2024-08-17

phthalide and benzofurans

phthalide has been researched along with benzofurans in 169 studies

Research

Studies (169)

TimeframeStudies, this research(%)All Research%
pre-19902 (1.18)18.7374
1990's2 (1.18)18.2507
2000's39 (23.08)29.6817
2010's94 (55.62)24.3611
2020's32 (18.93)2.80

Authors

AuthorsStudies
Dobson, AJ; Gerkin, RE1
Dekker, KA; Gootz, TD; Inagaki, T; Kaneda, K; Kojima, N; Nomura, E; Sakakibara, T; Sakemi, S; Sugie, Y; Yamauchi, Y; Yoshikawa, N1
Crippa, L; Di Fabio, R; Donati, D; Leslie, C; Micheli, F1
Dorsch, WA; Hauser, FM; Mal, D1
DALEV, D; VELICHKOV, L1
INUBUSHI, Y; KONITA, T; MATSUMOTO, S; TSUDA, Y1
Dorsch, WA; Hauser, FM1
Li, X; Liang, X; Wang, J; Xiao, H; Xu, Q; Zhang, X1
Ishikawa, T; Kitajima, J; Satoh, M1
Mori, K; Ohzeki, T1
Anzai, J; Ishikawa, Y; Miyazawa, M; Tsukamoto, T1
Chen, J; Ditullio, D; Hughes, DE; Knight-Connoni, V; Millett, WP; Mullady, EL; Pierceall, WE; Weiskopf, AS; Yoo, HD1
Fu, FH; Jiang, WL; Sun, F; Tian, JW; Wang, CY; Zhang, TP1
Harada, N; Hiroi, K; Kosaka, M; Kuwahara, S; Naito, J; Sekiguchi, S; Uemura, M; Watanabe, M1
del Olmo, E; Herrera-Ruiz, M; López-Pérez, JL; San Feliciano, A; Tortoriello, J; Zamilpa, A1
Ishikawa, Y; Miyazawa, M; Tsukamoto, T1
Cheng, YY; Deng, T; Liu, L; Lu, XP; Ning, ZQ; Shan, S; Zhang, K1
Anwar, MU; Bayer, E; Choudhary, MI; Hayat, S; Imran-ul-Haq, M; Khan, KM; Shah, ST; Voelter, W1
Fujita, A; Kouno, E; Kubota, K; Kurobayashi, Y; Morimitsu, Y1
Almeida, WP; Coelho, F; De Carvalho, JE; Kohn, LK; Pavam, CH; Veronese, D1
Ding, LS; Li, YH; Peng, SL; Yu, KB; Zhou, Y1
Asada, T; Hori, T; Kawata, K; Nissato, K; Oikawa, K; Shiota, N1
Hirano, M; Noguchi, K; Osaka, T; Tanaka, K1
Beck, JJ; Chou, SC1
Mal, D; Ray, S; Sharma, I1
Huang, YT; Lee, TF; Lin, YL1
Trost, BM; Weiss, AH1
Futamata, H; Hiraishi, A; Kaiya, S; Kurogi, T; Yoshida, N1
Fujita, A; Katsumi, Y; Kubota, K; Kurobayashi, Y; Morimitsu, Y1
Kittakoop, P; Mahidol, C; Prachyawarakorn, V; Ruchirawat, S; Sangpetsiripan, S; Sureram, S; Wiyakrutta, S1
Brimble, MA; Bryant, CJ; Flowers, CL; Fraser, JD; Heapy, AM; Radcliff, FJ; Robinson, JE; Wilson, ZE1
Wu, Q; Yang, XW1
Cao, J; Cheng, XL; Ge, XX; Li, CY; Li, P; Qi, LW; Wang, YX; Wen, XD; Yi, L1
Cho, CH; Kan, WL; Lin, G; Rudd, JA1
Chaithong, U; Choochote, W; Jitpakdi, A; Junkum, A; Kanjanapothi, D; Pitasawat, B; Pongpaibul, Y; Riyong, D; Tuetun, B1
Chang, YC; Chen, IS; Chen, JJ; Cheng, LY; Cho, JY; Chou, TH; Hwang, TL; Lee, TH; Wang, TC1
Cai, SQ; Li, J; Li, XM; Meng, LQ; Shang, MY; Xu, LW1
Akber Aisa, H; Kungurhan, B; Liu, Y; Lv, H; Sabir, G1
Brimble, MA; Sejberg, JJ; Sperry, J; Stiemke, FM1
Phuwapraisirisan, P; Rangsan, J; Siripong, P; Tip-Pyang, S1
Lin, GQ; Xu, MH; Zhang, B1
Ishiyama, N; Kuriyama, M; Onomura, O; Shimazawa, R; Shirai, R1
Duan, W; Liu, L; Luo, G; Wang, W; Zhang, H; Zhang, S1
Ding, A; Duan, JA; Hua, Y; Lu, Y; Su, S; Tang, Y; Yu, S; Zhang, X; Zhu, M1
Chang, XL; Chen, JJ; Jiang, ZY; Ma, YB; Tsim, KW; Zhang, XM1
He, P; Hu, QS; Liao, YX; Xing, CH1
Cheng, J; Lv, G; Wang, W; Ye, Z; Zhang, M1
Jimenez, R; Maldonado, LA; Salgado-Zamora, H1
Hashimoto, T; Inose, T; Kimura, T; Kokudo, N; Yamamoto, K; Yoshikawa, K1
Cheng, J; Luo, F; Lv, G; Qian, P; Ye, Z1
Guo, DA; Han, J; Qiao, X; Xu, M; Ye, G; Ye, M; Zhang, ZC1
Jiao, WH; Li, B; Shao, P; Wu, LJ; Yao, XS; Zhang, X1
Kittakoop, P; Mahidol, C; Prachya, S; Ruchirawat, S; Tianpanich, K; Wiyakrutta, S1
Li, CY; Li, P; Qi, LW1
Ghosh, K; Jana, AK; Mal, D; Mitra, P1
Ahn, YJ; Chae, SH; Kim, SI; Lee, SW; Yeon, SH1
Delgado, G; León, A; Tortoriello, J; Toscano, RA1
Cheng, CH; Karthikeyan, J; Parthasarathy, K1
Hu, QB; Luo, DQ; Yang, XL; Zhang, S; Zhang, Y1
Chen, YY; Cheng, DP; Li, XN; Qu, HB; Tong, SQ; Yan, JZ1
Deng, HY; Luo, DQ; Xing, JG1
De, SR; Mal, D; Mitra, P; Sarkar, A; Shome, B1
Busto, E; Gotor, V; Gotor-Fernández, V; Mangas-Sánchez, J1
Kwiatkowski, J; Lu, Y; Luo, J; Wang, H; Xu, LW; Zhong, F2
Kiran, IN; Reddy, RS; Sudalai, A1
Augner, D; Gerbino, DC; Schmalz, HG; Slavov, N1
Buatong, J; Phongpaichit, S; Rodglin, A; Rukachaisirikul, V; Sakayaroj, J; Sukpondma, Y1
Chen, GY; Dou, X; Lu, Y; Luo, J; Zhong, F1
Dudding, T; Mirabdolbaghi, R1
Li, L; Si, YK1
Chung, HY; Hong, J; Jung, JH; Kim, EL; Li, JL; Liu, J; Park, M; Xiao, B; Yin, J1
Brimble, MA; Yuen, TY1
Fei, XD; Ge, ZY; Ji, SJ; Tang, T; Zhu, YM1
Bergh, JJ; Petzer, JP; Strydom, B1
Baire, B; Hoye, TR; Niu, D; Willoughby, PH; Woods, BP1
Gu, Y; Huang, W; Wei, Y1
Chen, C; Yang, RL1
De Petrocellis, L; Di Marzo, V; Morera, E; Nalli, M; Ortar, G; Schiano Moriello, A1
Wang, S; Zhan, J; Zhang, S; Zhou, T1
Jain, S; Joshi, BD; Mishra, R; Srivastava, A; Tandon, P1
Juwaini, NA; Seayad, J; Tan, PW1
Danoun, G; Gooßen, LJ; Mamone, P1
Huang, J; Li, GY; Li, LH; Lin, RC; Lu, J; Lu, XQ; Wang, HY; Wang, JH1
Bai, YJ; Kong, M; Li, SL; Liu, LF; Wang, XN; Xu, JD; Zhang, XL; Zhou, SS1
Park, JH; Song, HS; Youn, SW1
Ma, SC; Ren, J; Su, YL; Wang, AG; Wei, Q; Yang, JB1
Karmakar, R; Mal, D; Pahari, P1
Chang, J; Hua, YZ; Shi, JG; Song, X; Sun, PP; Wang, MC1
Duan, JA; Li, W; Qian, Y; Shang, E; Su, S; Tang, Y; Wang, L; Zhang, L1
Buschhaus, L; Fröbel, S; Gilch, P; Villnow, T; Weingart, O1
Feng, T; Guo, H; Li, ZH; Liu, JK1
Miura, H; Shishido, T; Tsutsui, K; Wada, K1
Del-Ángel, M; Delgado, G; Nieto, A; Ramírez-Apan, T1
Hu, ZP; Liao, WW; Zhuang, Z1
Chi, YR; Li, B; Mou, C; Smetankova, M; Song, BA; Zhu, T1
Arcadi, A; Fabrizi, G; Goggiamani, A; Marinelli, F1
Dong, X; Gao, W; Li, MN; Li, P; Liu, XG; Wang, R; Yang, H1
Chen, GD; Gao, H; Guo, LD; Li, J; Sun, X; Wang, GQ; Wu, ZY; Zhao, H; Zhao, Q; Zou, J1
Liang, J; Xu, F; Yang, DH; Yang, XW; Yang, XY; Zhang, L; Zhao, X; Zhou, QL1
Dong, P; Kraus, GA1
Alvino, A; Ballero, M; Bianco, A; Lattanzi, C; Maggi, F; Ornano, L; Sanna, C; Serafini, M; Venditti, A1
Hosoe, T; Itabashi, T; Kawai, K; Saito, T; Takeda, H; Wakana, D; Yaguchi, T1
Chen, P; Lu, M; Nicolaou, KC; Shah, AA1
Crews, P; Di, DL; Li, J; Niu, HT; Shi, YP; Wu, QX; Xiao, H; Zhai, MM1
Cai, H; Pei, K; Qiao, FX; Song, XQ; Tu, PF1
Alvarenga, ES; Campos, JN; de Araújo, TA; Pincanço, MC; Resende, GC1
Bian, Q; Dai, R; Lee, DY; Ma, W; Peng, Y; Wang, N; Wang, W1
Chung, HY; Eom, SH; Hong, J; Jung, JH; Kim, ND; Liu, S; Noh, TH; Su, M; Yang, MH1
Liu, JW; Lv, JL; Zhang, LB1
Bourdy, G; Castillo, D; Cerapio, JP; Gadea, A; Haddad, M; Jullian, V; Paloque, L; Sauvain, M; Vásquez-Ocmín, P1
Chen, ZB; Yuan, Q; Zhang, FL; Zhu, YM1
Wei, W; Xu, W; Yang, XW1
Fu, S; Gao, X; Huang, Z; Liu, Y; Lu, Z; Qiao, Y; Wang, M; Wang, Q; Xie, Z; Yu, H; Zhang, Q; Zhang, Z; Zhao, H1
He, M; Hu, Y; Nie, J; Yan, P; Yang, TB; Yang, ZY; Ye, Y1
Du, JC; Peng, C; Sun, C; Xie, XF; Xiong, L1
Alvarenga, ES; Farias, ES; Ferreira, JS; Picanço, MC; Silva, EMP; Teixeira, MG1
Cabrera, JM; Krische, MJ; Tauber, J1
Cheng, C; Du, F; Huang, Y; Li, C; Li, L; Li, Y; Olaleye, OE; Shi, Y; Sun, Y; Wang, F; Wen, Q; Xu, F; Yang, J; Zhang, N1
Gao, X; Huo, M; Qiao, Y; Zhang, Q; Zhang, Y1
Kamauchi, H; Kawazoe, N; Kinoshita, K; Kojima, A; Koyama, K; Shiraishi, Y1
Boratyński, F; Gach, J; Olejniczak, T; Pannek, J1
Li, DX; Li, XW; Liu, WY; Tong, L; Yang, DL1
Guo, LM; Lv, JL; Zhang, LB1
Adil, M; Jeong, BR; Kang, DI; Ren, X; Thi, LT1
Chemler, SR; Chen, D1
Alvarenga, ES; Araújo, TA; Campos, JND; Farias, ES; Picanço, MC; Pimentel, MF; Resende, GC1
Fukumoto, K; Renzetti, A1
Fan, X; Ke, H; Lu, X; Tong, W; Xue, R1
Chen, GD; Gao, H; He, RR; Qu, YB; So, KF; Wang, XX; Yao, XS; Zhang, ZJ; Zhao, H; Zou, J1
Li, L; Su, Y; Wang, A; Wei, Q; Yang, J1
Adil, M; Jeong, BR; Ren, X1
Chen, GD; Gao, H; Guo, LD; Hu, D; Liu, YY; Xie, J; Yao, XS; Zhao, H; Zou, J1
Bai, G; Deng, YF; Hu, XY; Jiang, M; Lei, W; Ni, JN1
Bai, DT; Cao, HH; Chen, J; Cheng, M; Gu, LY; Guo, S; Hu, W; Li, L; Lu, TL; Mao, CQ; Yan, WH1
Banwell, MG; Gardiner, MG; Lan, P; Sheng, B; Sun, P; Vo, Y1
Boonruangprapa, T; Bunbamrung, N; Dramae, A; Intaraudom, C; Pittayakhajonwut, P; Punyain, W1
Fang, X; Feng, Y; Jin, YS; Liang, S; Ma, Q; Yao, SY; Zhang, KX1
Alvarenga, ES; Pinto, BNS; Teixeira, MG1
Abbod, M; Bonsaii, M; Gholivand, K; Mehrabadi, M; Safaie, N1
Bagul, KT; Duggal, H; Gacche, R; Kamble, S; Lokhande, P; Meshram, R; Patil, A1
Chen, C; Du, JR; Li, X; Shi, MQ1
Coelho Nogueira, KOP; de Brito, ACF; Dos Reis Teixeira, A; Manhabosco, TM; Oliveira, LAM; Pereira, WL; Ribeiro, IML; Teixeira, RR1
Chen, LZ; Chen, R; Li, K; Liu, XH; Ruan, BF; Wu, J; Wu, QQ1
Bruijnincx, PCA; Bulo, RE; Cioc, RC; Crockatt, M; Fölker, B; Lancefield, CS; Lutz, M; Stanciakova, K1
Chen, C; Du, JR; Duan, W; Gan, YM; Liu, DL; Yang, YX1
Dai, H; Dai, Y; Li, K; Liao, S; Lin, X; Liu, Y; She, J; Tao, H; Wang, H; Wang, J; Yang, B; Zeng, Y; Zhou, X1
Chen, J; Jin, L; Shi, T; Xu, X; Zhu, T1
Chi, LP; Li, X; Li, XM; Wan, YP; Wang, BG1
Chen, K; Chen, XL; He, YW; Kong, LY; Liu, XQ; Luo, JG; Wang, SB1
Cao, Z; Cong, S; Deng, Y; Liu, Z; Song, Q; Tan, Z; Yu, G1
Feng, JF; Li, DX; Liu, XM; Wei, XH; Wu, QY; Xia, MY; Zhang, GS; Zhong, YH1
Deng, P; Feng, JF; Hu, PY; Lei, ZQ; Li, DX; Liu, XM; Zhang, GS; Zhang, WL; Zhong, YH1
Bararjanian, M; Bischoff-Kont, I; Fürst, R; Hadian, N; Hassanpour, Z; Jung, Y; Lucena-Agell, D; Mohebbi, M; Nasiri, HR; Nejad-Ebrahimi, S; Nemati, F; Oliva, MA; Salehi, P; Schaerlaekens, S1
He, B; Li, H; Liu, S; Shang, Y; Su, W; Zhang, X1
Chen, D; Chen, Y; Kang, F; Kuang, M; Peng, W; Tan, J; Xu, K; Zhang, S; Zou, Z1
Baek, NI; Kang, TH; Kim, HG; Kim, NW; Lee, DY; Lee, MH; Nam, YH; Nguyen, TN; Oh, SM; Shim, JH1
Chen, Q; Li, G; Xu, B; Yang, J; Yu, K1
Chen, P; Ding, B; Huang, H; Li, C; Liu, J; Peng, J; Sun, Y; Tao, Y; Yang, M1
Beeralingappa, NC; Chavan, PN; Dethe, DH; Siddiqui, SA1
Dai, O; Feng, R; Liu, J; Liu, LS; Lu, Y; Ni, H; Peng, C; Shu, HZ; Xiong, L1
Li, WY; Li, XN; Wang, LY; Wu, XD; Zhao, QS; Zhao, XY; Zhou, HF1
Lu, J; Ran, GY; Shi, L; Xiong, Q1
Martinez, G; McClure, TJ; Navarro, R; Orozco, C; Saludares, C1
Meng, F; Sun, C; Wang, Y; Wei, X; Zeng, Y1
Feng, R; Guo, L; Huang, L; Peng, C; Shu, HZ; Tian, YC; Xiong, L; Zhou, QM1
Chen, L; Guo, W; Hu, Y; Ruan, B; Tang, X1
Baek, W; Hong, JE; Kim, K; Kwak, JH; Park, Y; Yoon, J1
Bai, J; Cai, G; Cen, S; He, W; Wang, J; Wang, Y; Yu, L; Zhang, R; Zhang, T; Zhao, J1

Reviews

7 review(s) available for phthalide and benzofurans

ArticleYear
The structural diversity of phthalides from the Apiaceae.
    Journal of natural products, 2007, Volume: 70, Issue:5

    Topics: Apiaceae; Benzofurans; Molecular Structure; Plants, Medicinal

2007
Phthalides and phthalans: synthetic methodologies and their applications in the total synthesis.
    Chemical reviews, 2014, Jun-25, Volume: 114, Issue:12

    Topics: Anti-Bacterial Agents; Bacteria; Benzoates; Benzofurans; Biological Products; Cyclization; Lactones; Oxidation-Reduction; Phthalimides

2014
[Research progress of chemical constituents and pharmacological activities of essential oil of Ligusticum chuanxiong].
    Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 2016, Volume: 41, Issue:23

    Topics: Animals; Benzofurans; Drugs, Chinese Herbal; Fatty Acids; Humans; Ligusticum; Oils, Volatile; Terpenes

2016
Antimicrobial activity of extracts and phthalides occurring in Apiaceae plants.
    Phytotherapy research : PTR, 2018, Volume: 32, Issue:8

    Topics: Anti-Infective Agents; Apiaceae; Bacteria; Benzofurans; Fungi; Microbial Sensitivity Tests; Plant Extracts

2018
Synthesis of Phthalides and α,β-butenolides by Transition Metal-Catalyzed Activation of C-H Bonds.
    Molecules (Basel, Switzerland), 2019, Feb-25, Volume: 24, Issue:4

    Topics: 4-Butyrolactone; Benzofurans; Catalysis; Coordination Complexes; Cycloaddition Reaction; Molecular Structure; Oxidation-Reduction; Transition Elements

2019
Synthesis of New 3-Arylaminophthalides and 3-Indolyl-phthalides using Ammonium Chloride, Evaluation of their Anti-Mycobacterial Potential and Docking Study.
    Combinatorial chemistry & high throughput screening, 2020, Volume: 23, Issue:8

    Topics: Algorithms; Ammonium Chloride; Antioxidants; Antitubercular Agents; Benzofurans; Drug Design; Humans; Hydroxyl Radical; Microbial Sensitivity Tests; Molecular Docking Simulation; Mycobacterium tuberculosis; Nucleotide Deaminases; Structure-Activity Relationship; Tuberculosis

2020
Recent advances in natural phthalides: Distribution, chemistry, and biological activities.
    Fitoterapia, 2022, Volume: 160

    Topics: Anti-Inflammatory Agents; Benzofurans; Fungi; Molecular Structure; Plants

2022

Other Studies

162 other study(ies) available for phthalide and benzofurans

ArticleYear
2-Acetylbenzoic acid: phthalide form.
    Acta crystallographica. Section C, Crystal structure communications, 1996, Dec-15, Volume: 52 ( Pt 12)

    Topics: Benzofurans; Crystallography, X-Ray; Hydrogen Bonding; Molecular Structure

1996
CJ-12,954 and its congeners, new anti-Helicobacter pylori compounds produced by Phanerochaete velutina: fermentation, isolation, structural elucidation and biological activities.
    The Journal of antibiotics, 1997, Volume: 50, Issue:10

    Topics: Anti-Bacterial Agents; Anti-Infective Agents; Basidiomycota; Benzofurans; Fermentation; Helicobacter pylori; Microbial Sensitivity Tests; Molecular Structure; Spiro Compounds; Structure-Activity Relationship

1997
A new alternative synthesis of 5-cyanophthalide, a versatile intermediate in the preparation of the antidepressant drug citalopram.
    Farmaco (Societa chimica italiana : 1989), 2001, Volume: 56, Issue:9

    Topics: Antidepressive Agents, Second-Generation; Benzofurans; Citalopram

2001
Total synthesis of (+/-)-O-methyl PD 116740.
    Organic letters, 2002, Jun-27, Volume: 4, Issue:13

    Topics: Benz(a)Anthracenes; Benzofurans; Hydroxylation; Quinones; Stereoisomerism; Sulfides

2002
[Structure of the isomeric indones of the phthalide of beta-ethoxyphthalic anhydride].
    Nauchni trudove na Visshiia meditsinski institut, Sofiia, 1962, Volume: 41(4)

    Topics: Anhydrides; Benzofurans; Indans; Phthalic Acids

1962
SHIHUNINE: A NEW PHTHALIDE-PYRROLIDINE ALKALOID.
    Chemical & pharmaceutical bulletin, 1964, Volume: 12

    Topics: Alkaloids; Benzofurans; Chemistry, Pharmaceutical; Lactones; Phthalic Acids; Pyrroles; Pyrrolidines; Research

1964
A new regiospecific preparation of xanthones.
    Organic letters, 2003, Oct-02, Volume: 5, Issue:20

    Topics: Benzofurans; Benzopyrans; Stereoisomerism; Xanthones

2003
Characterization of phthalides in Ligusticum chuanxiong by liquid chromatographic-atmospheric pressure chemical ionization-mass spectrometry.
    Journal of chromatographic science, 2003, Volume: 41, Issue:8

    Topics: Atmospheric Pressure; Benzofurans; Chromatography, High Pressure Liquid; Dimerization; Drugs, Chinese Herbal; Ligusticum; Mass Spectrometry

2003
Polar constituents of celery seed.
    Phytochemistry, 2003, Volume: 64, Issue:5

    Topics: Apium; Benzofurans; Carotenoids; Glucosides; Glycosides; Lignans; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Plant Extracts; Plants, Medicinal; Seeds; Sesquiterpenes

2003
Synthesis and absolute configuration of (-)-3-butyl-7-hydroxyphthalide, a cytotoxic metabolite of Penicillium vulpinum.
    Bioscience, biotechnology, and biochemistry, 2003, Volume: 67, Issue:10

    Topics: Benzofurans; Cytotoxins; Hydroxylation; Magnetic Resonance Spectroscopy; Penicillium; Stereoisomerism

2003
Insecticidal effect of phthalides and furanocoumarins from Angelica acutiloba against Drosophila melanogaster.
    Journal of agricultural and food chemistry, 2004, Jul-14, Volume: 52, Issue:14

    Topics: Angelica; Animals; Benzofurans; Cholinesterase Inhibitors; Drosophila melanogaster; Female; Furocoumarins; Insecticides; Larva; Male; Structure-Activity Relationship

2004
A phthalide with in vitro growth inhibitory activity from an oidiodendron strain.
    Journal of natural products, 2004, Volume: 67, Issue:12

    Topics: Antineoplastic Agents; Benzofurans; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Fungi; Humans; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Tumor Cells, Cultured

2004
[Protective effect of ligusticum chuanxiong phthalides on focai cerebral ischemia in rats and its related mechanism of action].
    Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 2005, Volume: 30, Issue:6

    Topics: Animals; Benzofurans; Blood Viscosity; Brain Ischemia; Dose-Response Relationship, Drug; Hematocrit; Infarction, Middle Cerebral Artery; Ligusticum; Male; Neuroprotective Agents; Plants, Medicinal; Platelet Aggregation; Rats; Rats, Wistar; Venous Thrombosis

2005
Synthesis of enantiopure phthalides including 3-butylphthalide, a fragrance component of celery oil, and determination of their absolute configurations.
    Chirality, 2005, May-05, Volume: 17, Issue:4

    Topics: Alcohols; Apium; Benzofurans; Chromatography, High Pressure Liquid; Esters; Molecular Structure; Oils, Volatile; Perfume; Plant Oils; Silica Gel; Silicon Dioxide; Spectrum Analysis; Stereoisomerism

2005
Anxiolytic effects of benzalphthalides.
    Bioorganic & medicinal chemistry letters, 2005, Aug-01, Volume: 15, Issue:15

    Topics: Animals; Anti-Anxiety Agents; Anxiety; Benzamides; Benzodiazepines; Benzofurans; Brain; Dose-Response Relationship, Drug; Maze Learning; Mice

2005
Larvicidal and adulticidal activity of alkylphthalide derivatives from rhizome of Cnidium officinale against Drosophila melanogaster.
    Journal of agricultural and food chemistry, 2005, Jul-13, Volume: 53, Issue:14

    Topics: Alkylation; Animals; Benzofurans; Chloroform; Cholinesterase Inhibitors; Cnidium; Drosophila melanogaster; Insecticides; Larva; Plant Extracts; Rhizome

2005
Phthalide Lactones from Ligusticum chuanxiong inhibit lipopolysaccharide-induced TNF-alpha production and TNF-alpha-mediated NF-kappaB Activation.
    Planta medica, 2005, Volume: 71, Issue:9

    Topics: Benzofurans; Humans; Lactones; Ligusticum; Lipopolysaccharides; Monocytes; NF-kappa B; Phytotherapy; Plant Extracts; Reverse Transcriptase Polymerase Chain Reaction; Rhizome; Tumor Necrosis Factor-alpha

2005
Efficient synthesis of isobenzofuran-1(3H)-ones (phthalides) and selected biological evaluations.
    Arzneimittel-Forschung, 2005, Volume: 55, Issue:10

    Topics: Animals; Anti-Bacterial Agents; Antifungal Agents; Artemia; Bacteria; Benzofurans; Fungi; Indicators and Reagents; Lethal Dose 50; Microbial Sensitivity Tests; Structure-Activity Relationship

2005
Potent odorants characterize the aroma quality of leaves and stalks in raw and boiled celery.
    Bioscience, biotechnology, and biochemistry, 2006, Volume: 70, Issue:4

    Topics: Adult; Apium; Benzofurans; Female; Hot Temperature; Humans; Male; Models, Biological; Molecular Structure; Plant Extracts; Plant Leaves; Plant Stems; Smell; Water

2006
Antiproliferative effect of Baylis-Hillman adducts and a new phthalide derivative on human tumor cell lines.
    European journal of medicinal chemistry, 2006, Volume: 41, Issue:6

    Topics: Benzofurans; Cell Line, Tumor; Cell Proliferation; Humans; Magnetic Resonance Spectroscopy; Spectrophotometry, Infrared; Structure-Activity Relationship

2006
Two new phthalides from Ligusticum chuanxiong.
    Planta medica, 2006, Volume: 72, Issue:7

    Topics: Benzofurans; Crystallography, X-Ray; Ligusticum; Spectrum Analysis

2006
Runoff of aerially applied phthalide from paddy fields.
    Bulletin of environmental contamination and toxicology, 2006, Volume: 77, Issue:4

    Topics: Agriculture; Benzofurans; Fresh Water; Fungicides, Industrial; Gas Chromatography-Mass Spectrometry; Japan; Oryza; Water Pollutants, Chemical

2006
Rhodium-catalyzed asymmetric one-pot transesterification and [2 + 2 + 2] cycloaddition leading to enantioenriched 3,3-disubstituted phthalides.
    Organic letters, 2007, Mar-29, Volume: 9, Issue:7

    Topics: Alkynes; Benzofurans; Catalysis; Models, Molecular; Molecular Structure; Polycyclic Compounds; Propanols; Rhodium; Stereoisomerism

2007
Direct access to 1,4-dihydroxyanthraquinones: the Hauser annulation reexamined with p-quinones.
    The Journal of organic chemistry, 2007, Jun-22, Volume: 72, Issue:13

    Topics: Anthracyclines; Anthraquinones; Benzofurans; Benzoquinones; Hydroxylation; Molecular Structure; Naphthacenes

2007
Studies on antiproliferative effects of phthalides from Ligusticum chuanxiong in hepatic stellate cells.
    Planta medica, 2007, Volume: 73, Issue:6

    Topics: Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Benzofurans; Cell Proliferation; Dose-Response Relationship, Drug; Flow Cytometry; Hepatocytes; Humans; In Situ Nick-End Labeling; Ligusticum; Liver Cirrhosis; Phytotherapy; Plant Extracts; Platelet-Derived Growth Factor; Rats; Rats, Sprague-Dawley; Rhizome

2007
An alkyne strategy for the asymmetric synthesis of natural products: application to (+)-spirolaxine methyl ether.
    Angewandte Chemie (International ed. in English), 2007, Volume: 46, Issue:40

    Topics: Alkynes; Benzofurans; Biological Products; Catalysis; Furans; Molecular Structure; Phenol; Spiro Compounds; Stereoisomerism

2007
Reductive dechlorination of chloroethenes by Dehalococcoides-containing cultures enriched from a polychlorinated-dioxin-contaminated microcosm.
    The ISME journal, 2007, Volume: 1, Issue:6

    Topics: Bacterial Proteins; Benzofurans; Chlorine; Chlorobenzenes; Chloroflexi; Dioxins; DNA Fingerprinting; DNA, Bacterial; DNA, Ribosomal; Electrophoresis, Polyacrylamide Gel; Fresh Water; Hydrogen; Molecular Sequence Data; Nucleic Acid Denaturation; Oxidation-Reduction; Polymerase Chain Reaction; RNA, Ribosomal, 16S; Sequence Analysis, DNA; Vinyl Chloride; Water Pollutants

2007
Flavor enhancement of chicken broth from boiled celery constituents.
    Journal of agricultural and food chemistry, 2008, Jan-23, Volume: 56, Issue:2

    Topics: Animals; Apium; Benzofurans; Chickens; Hot Temperature; Humans; Meat; Odorants; Solutions; Taste; Volatilization

2008
Diketopiperazines and phthalides from a marine derived fungus of the order pleosporales.
    Planta medica, 2008, Volume: 74, Issue:1

    Topics: Antineoplastic Agents, Phytogenic; Benzofurans; Cell Line, Tumor; Diketopiperazines; Fungi; Humans; Phytotherapy; Seawater

2008
Anti-Helicobacter pylori activity of derivatives of the phthalide-containing antibacterial agents spirolaxine methyl ether, CJ-12,954, CJ-13,013, CJ-13,102, CJ-13,104, CJ-13,108 and CJ-13,015.
    Bioorganic & medicinal chemistry, 2008, Jun-01, Volume: 16, Issue:11

    Topics: Anti-Bacterial Agents; Benzofurans; Helicobacter pylori; Heterocyclic Compounds; Microbial Sensitivity Tests; Spiro Compounds; Stereoisomerism; Structure-Activity Relationship

2008
[GC-MS analysis of essential oil from rhizomes of Ligusticum chuanxiong cultivated in GAP base for Chinese medicinal materials of China].
    Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 2008, Volume: 33, Issue:3

    Topics: Benzofurans; Gas Chromatography-Mass Spectrometry; Ligusticum; Molecular Structure; Oils, Volatile; Rhizome

2008
Rapid and sensitive screening and characterization of phenolic acids, phthalides, saponins and isoflavonoids in Danggui Buxue Tang by rapid resolution liquid chromatography/diode-array detection coupled with time-of-flight mass spectrometry.
    Rapid communications in mass spectrometry : RCM, 2008, Volume: 22, Issue:16

    Topics: Benzofurans; Chromatography, High Pressure Liquid; Drugs, Chinese Herbal; Hydroxybenzoates; Isoflavones; Plant Extracts; Reproducibility of Results; Saponins; Sensitivity and Specificity; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization

2008
Study of the anti-proliferative effects and synergy of phthalides from Angelica sinensis on colon cancer cells.
    Journal of ethnopharmacology, 2008, Oct-30, Volume: 120, Issue:1

    Topics: Adenocarcinoma; Angelica; Antineoplastic Agents, Phytogenic; Benzofurans; Cell Line; Cell Proliferation; Cell Survival; Colorectal Neoplasms; Dose-Response Relationship, Drug; Drug Synergism; Drugs, Chinese Herbal; HT29 Cells; Humans; Inhibitory Concentration 50; Plant Extracts

2008
Celery-based topical repellents as a potential natural alternative for personal protection against mosquitoes.
    Parasitology research, 2008, Volume: 104, Issue:1

    Topics: Administration, Topical; Adult; Aedes; Animals; Apium; Benzofurans; DEET; Female; Humans; Insect Bites and Stings; Insect Repellents; Male; Middle Aged; Plant Extracts; Sesquiterpenes; Sesquiterpenes, Eudesmane; Skin; Tetrahydronaphthalenes; Young Adult

2008
Phthalides from Pittosporum illicioides var. illicioides with inhibitory activity on superoxide generation and elastase release by neutrophils.
    Journal of natural products, 2008, Volume: 71, Issue:10

    Topics: Benzofurans; Cytochalasin B; Humans; Inhibitory Concentration 50; Molecular Structure; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Nuclear Magnetic Resonance, Biomolecular; Pancreatic Elastase; Plant Roots; Plants, Medicinal; Rosales; Rotenone; Superoxides; Taiwan

2008
[Analysis of principal composition of ethyl acetate part in Huangqi Danggui decoction by HPLC-ESI-TOF-MS].
    Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 2008, Volume: 33, Issue:21

    Topics: Acetates; Amino Acids; Benzofurans; Chromatography, High Pressure Liquid; Drugs, Chinese Herbal; Flavonoids; Glycosides; Molecular Weight; Oligosaccharides; Saponins; Spectrometry, Mass, Electrospray Ionization

2008
New phthalide glycosides from Helichrysum arenarium (L.) Moench.
    Journal of Asian natural products research, 2009, Volume: 11, Issue:4

    Topics: Benzofurans; Drugs, Chinese Herbal; Glycosides; Helichrysum; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular

2009
Biomimetic studies towards the cardinalins: synthesis of (+)-ventiloquinone L and an unusual dimerisation.
    Organic & biomolecular chemistry, 2009, Jun-21, Volume: 7, Issue:12

    Topics: Benzofurans; Benzoquinones; Biological Products; Biomimetics; Dimerization; Naphthoquinones; Plant Roots; Pyrans; Rhamnaceae; Stereoisomerism

2009
New antitumour fungal metabolites from Alternaria porri.
    Natural product research, 2009, Volume: 23, Issue:12

    Topics: Alternaria; Anthraquinones; Antineoplastic Agents; Benzofurans; Colorimetry; Drug Screening Assays, Antitumor; HeLa Cells; Humans; Inhibitory Concentration 50; KB Cells; Lactones; Magnetic Resonance Spectroscopy; Molecular Structure; Phthalic Acids

2009
Catalytic enantioselective synthesis of chiral phthalides by efficient reductive cyclization of 2-acylarylcarboxylates under aqueous transfer hydrogenation conditions.
    Organic letters, 2009, Oct-15, Volume: 11, Issue:20

    Topics: Benzofurans; Carboxylic Acids; Catalysis; Cyclization; Diamines; Hydrogenation; Ligands; Oxidation-Reduction; Ruthenium; Stereoisomerism; Substrate Specificity; Water

2009
Efficient synthesis of 3-arylphthalides using palladium-catalyzed arylation of aldehydes with organoboronic acids.
    The Journal of organic chemistry, 2009, Dec-04, Volume: 74, Issue:23

    Topics: Aldehydes; Benzofurans; Boronic Acids; Catalysis; Hydrocarbons, Aromatic; Palladium

2009
Synthesis of chiral 3-substituted phthalides by a sequential organocatalytic enantioselective aldol-lactonization reaction. Three-step synthesis of (S)-(-)-3-butylphthalide.
    The Journal of organic chemistry, 2010, Jan-15, Volume: 75, Issue:2

    Topics: Aldehydes; Benzofurans; Catalysis; Cyclization; Ketones; Magnetic Resonance Spectroscopy; Molecular Structure; Stereoisomerism; Structure-Activity Relationship

2010
Identification and comparative quantification of bio-active phthalides in essential oils from si-wu-tang, fo-shou-san, radix angelica and rhizoma chuanxiong.
    Molecules (Basel, Switzerland), 2010, Jan-15, Volume: 15, Issue:1

    Topics: Angelica sinensis; Animals; Benzofurans; Drugs, Chinese Herbal; Female; Gas Chromatography-Mass Spectrometry; Mice; Oils, Volatile; Uterine Contraction

2010
Two new compounds from the roots of Ligusticum chuanxiong.
    Journal of Asian natural products research, 2009, Volume: 11, Issue:9

    Topics: Benzofurans; Crystallography, X-Ray; Cyclohexanones; Drugs, Chinese Herbal; Glycosides; Ligusticum; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Plant Roots; Rhizome

2009
Transition metal-catalyzed addition reactions of arylboronic acids with alkyl 2-formylbenzoates: efficient access to chiral 3-substituted phthalides.
    Chemical communications (Cambridge, England), 2010, May-07, Volume: 46, Issue:17

    Topics: Benzoates; Benzofurans; Boronic Acids; Catalysis; Organometallic Compounds; Stereoisomerism; Transition Elements

2010
Rhodium-catalyzed cascade reaction: aryl addition/intramolecular esterification to access 3-aryl and 3-alkenyl phthalides.
    Angewandte Chemie (International ed. in English), 2010, May-10, Volume: 49, Issue:21

    Topics: Benzofurans; Boron; Catalysis; Esters; Heterocyclic Compounds; Molecular Structure; Rhodium

2010
Synthesis of demethylated nidulol via an intramolecular Michael reaction.
    Natural product research, 2010, Volume: 24, Issue:13

    Topics: Benzofurans; Lactones; Molecular Structure; Phthalic Anhydrides; Spectrophotometry, Infrared

2010
Novel phthalide compounds from Sparassis crispa (Hanabiratake), Hanabiratakelide A-C, exhibiting anti-cancer related activity.
    Biological & pharmaceutical bulletin, 2010, Volume: 33, Issue:8

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anticarcinogenic Agents; Antioxidants; Azoxymethane; Benzofurans; Caco-2 Cells; Cell Proliferation; Colonic Neoplasms; Dinoprostone; Dose-Response Relationship, Drug; Female; Humans; Macrophages; Magnetic Resonance Spectroscopy; Mice; Molecular Structure; Nitric Oxide; Polyporales; Rats; Rats, Inbred F344; Superoxide Dismutase

2010
Palladium-catalyzed cascade aryl addition/intramolecular lactonization of phthalaldehyde to access 3-aryl- and alkenylphthalides.
    The Journal of organic chemistry, 2010, Sep-03, Volume: 75, Issue:17

    Topics: Benzofurans; Boronic Acids; Catalysis; Cyclization; Lactones; Molecular Structure; o-Phthalaldehyde; Palladium; Stereoisomerism

2010
Metabolic profiling of GuanXin II prescription based on metabolic fingerprinting and chemical analysis.
    Journal of pharmaceutical and biomedical analysis, 2011, Mar-25, Volume: 54, Issue:4

    Topics: Animals; Benzofurans; Bicyclic Monoterpenes; Bile; Biotransformation; Chromatography, High Pressure Liquid; Coronary Artery Disease; Drugs, Chinese Herbal; Feces; Flavonoids; Male; Molecular Structure; Phenols; Polyphenols; Rats; Rats, Sprague-Dawley; Solid Phase Extraction; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry; Technology, Pharmaceutical; Terpenes

2011
New isocourmarin and phthalide derivatives from the rhizomes of Matteuccia orientalis.
    Chemical & pharmaceutical bulletin, 2010, Volume: 58, Issue:12

    Topics: Benzofurans; Circular Dichroism; Dryopteridaceae; Isocoumarins; Magnetic Resonance Spectroscopy; Mass Spectrometry; Molecular Conformation; Rhizome; Spectrophotometry, Infrared

2010
Radical scavenging and antioxidant activities of isocoumarins and a phthalide from the endophytic fungus Colletotrichum sp.
    Journal of natural products, 2011, Jan-28, Volume: 74, Issue:1

    Topics: Antineoplastic Agents; Antioxidants; Aromatase Inhibitors; Benzofurans; Biphenyl Compounds; Colletotrichum; Drug Screening Assays, Antitumor; Free Radical Scavengers; Hep G2 Cells; HL-60 Cells; Humans; Isocoumarins; Lactones; Molecular Structure; Picrates; Piper; Structure-Activity Relationship; Thailand

2011
Correlative analysis of metabolite profiling of Danggui Buxue Tang in rat biological fluids by rapid resolution LC-TOF/MS.
    Journal of pharmaceutical and biomedical analysis, 2011, Apr-28, Volume: 55, Issue:1

    Topics: Acetylcysteine; Animals; Benzofurans; Bile; Biotransformation; Chromatography, High Pressure Liquid; Dietary Supplements; Drugs, Chinese Herbal; Glucuronides; Glutathione; Isoflavones; Male; Metabolome; Rats; Rats, Sprague-Dawley; Saponins; Solid Phase Extraction; Spectrometry, Mass, Electrospray Ionization

2011
Benzannulation for the regiodefined synthesis of 2-alkyl/aryl-1-naphthols: total synthesis of arnottin I.
    The Journal of organic chemistry, 2011, May-06, Volume: 76, Issue:9

    Topics: Acrylates; Benzofurans; Coumarins; Naphthols; Stereoisomerism; Substrate Specificity

2011
Adulticidal activity of phthalides identified in Cnidium officinale rhizome to B- and Q-biotypes of Bemisia tabaci.
    Journal of agricultural and food chemistry, 2011, Aug-10, Volume: 59, Issue:15

    Topics: Animals; Benzofurans; Cnidium; Female; Hemiptera; Insecticides; Male; Plant Extracts; Rhizome; Structure-Activity Relationship

2011
Phthalides and other constituents from Ligusticum porteri; sedative and spasmolytic activities of some natural products and derivatives.
    Natural product research, 2011, Volume: 25, Issue:13

    Topics: Benzofurans; Biological Products; Hypnotics and Sedatives; Ligusticum; Models, Molecular; Parasympatholytics; X-Ray Diffraction

2011
Synthesis of biarylketones and phthalides from organoboronic acids and aldehydes catalyzed by cobalt complexes.
    Chemical communications (Cambridge, England), 2011, Oct-07, Volume: 47, Issue:37

    Topics: Aldehydes; Benzofurans; Boronic Acids; Catalysis; Cobalt; Ketones; Organometallic Compounds

2011
Phthalide derivatives with antifungal activities against the plant pathogens isolated from the liquid culture of Pestalotiopsis photiniae.
    The Journal of antibiotics, 2011, Volume: 64, Issue:11

    Topics: Antifungal Agents; Benzofurans; Culture Media; Models, Molecular; Molecular Structure; Spectrum Analysis; Tracheophyta; Xylariales

2011
Two phthalide dimers from the radix of Angelica sinensis.
    Natural product research, 2012, Volume: 26, Issue:19

    Topics: Angelica sinensis; Benzofurans; Dimerization; Magnetic Resonance Spectroscopy; Molecular Structure; Plants, Medicinal

2012
Two new compounds from an endophytic fungus Pestalotiopsis heterocornis.
    Journal of Asian natural products research, 2011, Volume: 13, Issue:12

    Topics: Benzofurans; Glycosides; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Xylariales

2011
Stereoselective synthesis of hydroxy stilbenoids and styrenes by atom-efficient olefination with thiophthalides.
    Organic & biomolecular chemistry, 2012, Apr-14, Volume: 10, Issue:14

    Topics: Aldehydes; Alkenes; Benzofurans; Hydroxylation; Models, Molecular; Molecular Structure; Stereoisomerism; Stilbenes; Styrenes; Sulfhydryl Compounds

2012
Highly stereoselective chemoenzymatic synthesis of the 3H-isobenzofuran skeleton. Access to enantiopure 3-methylphthalides.
    Organic letters, 2012, Mar-16, Volume: 14, Issue:6

    Topics: Benzofurans; Catalysis; Molecular Structure; Stereoisomerism

2012
Direct asymmetric Mannich reaction of phthalides: facile access to chiral substituted isoquinolines and isoquinolinones.
    Chemical communications (Cambridge, England), 2012, May-16, Volume: 48, Issue:39

    Topics: Benzofurans; Catalysis; Isoquinolines; Molecular Structure; Quinolones; Stereoisomerism

2012
CN-assisted oxidative cyclization of cyano cinnamates and styrene derivatives: a facile entry to 3-substituted chiral phthalides.
    Organic & biomolecular chemistry, 2012, May-14, Volume: 10, Issue:18

    Topics: Benzofurans; Cinnamates; Cyclization; Molecular Structure; Nitriles; Oxidation-Reduction; Styrenes

2012
Nucleophile- or light-induced synthesis of 3-substituted phthalides from 2-formylarylketones.
    Organic letters, 2012, May-04, Volume: 14, Issue:9

    Topics: Benzofurans; Benzophenones; Biological Products; Catalysis; Dimethyl Sulfoxide; Ketones; Light; Molecular Structure

2012
Phthalide and isocoumarin derivatives produced by an Acremonium sp. isolated from a mangrove Rhizophora apiculata.
    Journal of natural products, 2012, May-25, Volume: 75, Issue:5

    Topics: Acremonium; Antifungal Agents; Benzofurans; Candida albicans; Cryptococcus neoformans; Isocoumarins; Microbial Sensitivity Tests; Molecular Structure; Rhizophoraceae; Thailand

2012
Highly enantioselective regiodivergent allylic alkylations of MBH carbonates with phthalides.
    Journal of the American Chemical Society, 2012, Jun-20, Volume: 134, Issue:24

    Topics: Alkylation; Allyl Compounds; Benzofurans; Carbonates; Stereoisomerism

2012
An indium-mediated allylative/transesterification DFT-directed approach to chiral C(3)-functionalized phthalides.
    Organic letters, 2012, Jul-20, Volume: 14, Issue:14

    Topics: Aldehydes; Benzofurans; Catalysis; Esterification; Indium; Molecular Structure; Quantum Theory

2012
Study on the absolute configurations of 3-alkylphthalides using TDDFT calculations of chiroptical properties.
    Chirality, 2012, Volume: 24, Issue:12

    Topics: Benzofurans; Biological Products; Models, Molecular; Molecular Conformation; Optical Phenomena; Quantum Theory; Rotation; Spectrum Analysis; Stereoisomerism

2012
Design and synthesis of marine fungal phthalide derivatives as PPAR-γ agonists.
    Bioorganic & medicinal chemistry, 2012, Aug-15, Volume: 20, Issue:16

    Topics: Animals; Benzofurans; Binding, Competitive; Cell Line; Drug Design; Liver; Models, Molecular; Molecular Structure; PPAR gamma; Rats

2012
Total synthesis of 7',8'-dihydroaigialospirol.
    Organic letters, 2012, Oct-05, Volume: 14, Issue:19

    Topics: Aldehydes; Alkenes; Alkynes; Benzofurans; Molecular Structure; Spiro Compounds

2012
Palladium-catalyzed synthesis of isocoumarins and phthalides via tert-butyl isocyanide insertion.
    The Journal of organic chemistry, 2012, Nov-16, Volume: 77, Issue:22

    Topics: Benzofurans; Catalysis; Cyclization; Hydrolysis; Isocoumarins; Lactones; Molecular Structure; Nitriles; Palladium

2012
Inhibition of monoamine oxidase by phthalide analogues.
    Bioorganic & medicinal chemistry letters, 2013, Mar-01, Volume: 23, Issue:5

    Topics: Benzofurans; Binding Sites; Humans; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Protein Binding; Structure-Activity Relationship

2013
Synthesis of complex benzenoids via the intermediate generation of o-benzynes through the hexadehydro-Diels-Alder reaction.
    Nature protocols, 2013, Volume: 8, Issue:3

    Topics: Benzene Derivatives; Benzofurans; Cycloaddition Reaction; Molecular Structure

2013
Online isolation and purification of four phthalide compounds from Chuanxiong rhizoma using high-speed counter-current chromatography coupled with semi-preparative liquid chromatography.
    Journal of chromatography. A, 2013, Apr-05, Volume: 1284

    Topics: Benzofurans; Chromatography, High Pressure Liquid; Countercurrent Distribution; Drugs, Chinese Herbal; Nuclear Magnetic Resonance, Biomolecular

2013
Highly diastereoselective and enantioselective direct Michael addition of phthalide derivatives to nitroolefins.
    Chemical communications (Cambridge, England), 2013, Jun-28, Volume: 49, Issue:51

    Topics: Alkenes; Amino Acids; Benzofurans; Catalysis; Crystallography, X-Ray; Lactams; Molecular Conformation; Stereoisomerism

2013
A phthalide derivative isolated from endophytic fungi Pestalotiopsis photiniae induces G1 cell cycle arrest and apoptosis in human HeLa cells.
    Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas, 2013, Volume: 46, Issue:8

    Topics: Apoptosis; Apoptosis Regulatory Proteins; Benzofurans; Cell Cycle Proteins; Cell Proliferation; Cycadopsida; Cyclin-Dependent Kinase Inhibitor p21; Cyclin-Dependent Kinase Inhibitor p27; DNA-Binding Proteins; Endophytes; Flow Cytometry; Forkhead Box Protein O1; Forkhead Transcription Factors; G1 Phase Cell Cycle Checkpoints; Genes, p16; HeLa Cells; Humans; Nuclear Proteins; Real-Time Polymerase Chain Reaction; Transcription Factors; Transcription, Genetic; Tumor Protein p73; Tumor Suppressor Proteins; Xylariales

2013
3-Ylidenephthalides as a new class of transient receptor potential channel TRPA1 and TRPM8 modulators.
    Bioorganic & medicinal chemistry letters, 2013, Oct-15, Volume: 23, Issue:20

    Topics: 4-Butyrolactone; Animals; Benzofurans; HEK293 Cells; Humans; Oxidation-Reduction; Protein Binding; Rats; TRPA1 Cation Channel; TRPC Cation Channels; TRPM Cation Channels

2013
Three new resorcylic acid derivatives from Sporotrichum laxum.
    Bioorganic & medicinal chemistry letters, 2013, Nov-01, Volume: 23, Issue:21

    Topics: Benzofurans; Biological Products; Biosynthetic Pathways; Hydroxybenzoates; Polyketide Synthases; Resorcinols; Sporothrix

2013
Quantum chemical and experimental studies on the structure and vibrational spectra of an alkaloid--Corlumine.
    Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 2014, Jan-24, Volume: 118

    Topics: Alkaloids; Benzofurans; Biological Products; GABA Antagonists; Isoquinolines; Models, Molecular; Molecular Conformation; Quantum Theory; Spectroscopy, Fourier Transform Infrared; Spectrum Analysis, Raman; Static Electricity; Thermodynamics

2014
Rhodium(III)-amine dual catalysis for the oxidative coupling of aldehydes by directed C-H activation: synthesis of phthalides.
    Organic letters, 2013, Oct-18, Volume: 15, Issue:20

    Topics: Aldehydes; Amines; Benzofurans; Catalysis; Molecular Structure; Organometallic Compounds; Oxidation-Reduction; Rhodium

2013
One-pot synthesis of 3-alkylidenephthalides from benzoic acids by a rhodium-catalyzed ortho-C-H acylation process.
    Chemistry (Weinheim an der Bergstrasse, Germany), 2013, Dec-16, Volume: 19, Issue:51

    Topics: Acylation; Benzoates; Benzofurans; Carbon; Catalysis; Coordination Complexes; Hydrogen; Rhodium

2013
Two new phthalides with BuChE inhibitory activity from Ligusticum chuanxiong.
    Journal of Asian natural products research, 2013, Volume: 15, Issue:12

    Topics: Benzofurans; Butyrylcholinesterase; Cholinesterase Inhibitors; Drugs, Chinese Herbal; Ligusticum; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Plant Roots

2013
Effect of different drying methods on the quality of Angelicae Sinensis Radix evaluated through simultaneously determining four types of major bioactive components by high performance liquid chromatography photodiode array detector and ultra-high performa
    Journal of pharmaceutical and biomedical analysis, 2014, Volume: 94

    Topics: Angelica sinensis; Benzofurans; Chromatography, High Pressure Liquid; Drugs, Chinese Herbal; Hydroxybenzoates; Plant Roots; Tandem Mass Spectrometry

2014
NHC-catalyzed oxidative cyclization reaction for the synthesis of 3-substituted phthalides.
    Organic & biomolecular chemistry, 2014, Apr-21, Volume: 12, Issue:15

    Topics: Benzofurans; Catalysis; Cyclization; Heterocyclic Compounds; Methane; Oxidation-Reduction

2014
New dimeric phthalides from Ligusticum sinense Oliv cv. Chaxiong.
    Journal of Asian natural products research, 2014, Volume: 16, Issue:7

    Topics: 4-Butyrolactone; Benzofurans; Crystallography, X-Ray; Drugs, Chinese Herbal; Ligusticum; Molecular Conformation; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Rhizome

2014
Diastereomeric aziridine carbinol catalyzed enantioselective arylation reaction: toward the asymmetric synthesis of both enantiomers of chiral 3-aryl phthalide.
    The Journal of organic chemistry, 2014, Jul-03, Volume: 79, Issue:13

    Topics: Aldehydes; Aziridines; Benzofurans; Catalysis; Molecular Structure; Stereoisomerism

2014
Comparative analysis of main aromatic acids and phthalides in Angelicae Sinensis Radix, Chuanxiong Rhizoma, and Fo-Shou-San by a validated UHPLC-TQ-MS/MS.
    Journal of pharmaceutical and biomedical analysis, 2014, Volume: 99

    Topics: Angelica sinensis; Benzofurans; Caffeic Acids; Chlorogenic Acid; Chromatography, High Pressure Liquid; Coumaric Acids; Drugs, Chinese Herbal; Ligusticum; Reproducibility of Results; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry

2014
The photoformation of a phthalide: a ketene intermediate traced by FSRS.
    Physical chemistry chemical physics : PCCP, 2015, Jan-07, Volume: 17, Issue:1

    Topics: Benzaldehydes; Benzofurans; Ethylenes; Isomerism; Ketones; Lactones; Light; Quantum Theory; Spectrum Analysis, Raman

2015
One new ergostane-type steroid and three new phthalide derivatives from cultures of the basidiomycete Albatrellus confluens.
    Journal of Asian natural products research, 2015, Volume: 17, Issue:2

    Topics: Antineoplastic Agents; Basidiomycota; Benzofurans; China; Drug Screening Assays, Antitumor; Ergosterol; HL-60 Cells; Humans; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Stereoisomerism

2015
Coupling of carboxylic acids with internal alkynes by supported ruthenium catalysts: direct and selective syntheses of multi-substituted phthalide derivatives.
    Chemical communications (Cambridge, England), 2015, Jan-31, Volume: 51, Issue:9

    Topics: Alkynes; Benzofurans; Carboxylic Acids; Catalysis; Molecular Structure; Ruthenium

2015
Anti-inflammatory effect of natural and semi-synthetic phthalides.
    European journal of pharmacology, 2015, Apr-05, Volume: 752

    Topics: Animals; Anti-Inflammatory Agents; Benzofurans; Biological Products; Carrageenan; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Edema; Inflammation; Male; Mice; Nitric Oxide Synthase; Nitrites; Peroxidase; RAW 264.7 Cells; Skin; Tetradecanoylphorbol Acetate

2015
Asymmetric Synthesis of Dihydronaphthoquinones Containing Adjacent Stereocenters via a Sulfa-Michael Addition Triggered Ring-Expansion Approach.
    The Journal of organic chemistry, 2015, May-01, Volume: 80, Issue:9

    Topics: Allyl Compounds; Benzofurans; Molecular Structure; Naphthoquinones; Stereoisomerism

2015
N-Heterocyclic Carbene-Catalyzed δ-Carbon LUMO Activation of Unsaturated Aldehydes.
    Journal of the American Chemical Society, 2015, May-06, Volume: 137, Issue:17

    Topics: Aldehydes; Benzene Derivatives; Benzofurans; Carbon; Catalysis; Cyclization; Heterocyclic Compounds; Methane; Molecular Structure; Stereoisomerism

2015
Pd- and Rh-Catalyzed Hydroarylation of γ-(2-Methoxycarbonylphenyl)propargylic Alcohols: Approaches to 4- or 5-Substituted Seven-Membered Benzolactones and 3,3-Disubstituted Phthalides.
    The Journal of organic chemistry, 2015, Jul-17, Volume: 80, Issue:14

    Topics: Alkynes; Benzofurans; Catalysis; Lactones; Molecular Structure; Palladium; Propanols; Rhodium

2015
Global identification and quantitative analysis of chemical constituents in traditional Chinese medicinal formula Qi-Fu-Yin by ultra-high performance liquid chromatography coupled with mass spectrometry.
    Journal of pharmaceutical and biomedical analysis, 2015, Oct-10, Volume: 114

    Topics: Alkaloids; Benzofurans; Calibration; Chromatography, High Pressure Liquid; Chromatography, Ion Exchange; Drugs, Chinese Herbal; Esters; Flavonoids; Ginsenosides; Glycosides; Lactones; Limit of Detection; Magnetic Resonance Spectroscopy; Medicine, Chinese Traditional; Reference Values; Reproducibility of Results; Saponins; Tandem Mass Spectrometry; Temperature; Triterpenes

2015
New α-pyrone and phthalide from the Xylariaceae fungus.
    Journal of Asian natural products research, 2015, Volume: 17, Issue:7

    Topics: Benzofurans; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Pyrones; Xylariales

2015
Metabolism of Chuanxiong Rhizoma decoction: Identification of the metabolites in WZS-miniature pig urine.
    Fitoterapia, 2015, Volume: 105

    Topics: Administration, Oral; Animals; Benzofurans; Drugs, Chinese Herbal; Hydroxybenzoates; Ligusticum; Male; Molecular Structure; Rhizome; Swine; Swine, Miniature; Urinalysis

2015
Phthalide Anions in Organic Synthesis. A Direct Total Synthesis of Furomollugin.
    Natural product communications, 2015, Volume: 10, Issue:6

    Topics: Anions; Benzofurans; Chemistry Techniques, Synthetic; Molecular Structure; Naphthols; Pyrones

2015
A new glucosidic phthalide from Helichrysum microphyllum subsp. tyrrhenicum from La Maddalena Island (Sardinia, Italy).
    Natural product research, 2016, Volume: 30, Issue:7

    Topics: Benzofurans; Caffeic Acids; Glucosides; Helichrysum; Italy; Molecular Structure; Monosaccharides; Phloroglucinol; Pyrones; Triterpenes; Ursolic Acid

2016
Isolation and structure elucidation of new phthalide and phthalane derivatives, isolated as antimicrobial agents from Emericella sp. IFM57991.
    The Journal of antibiotics, 2016, Volume: 69, Issue:2

    Topics: Anti-Infective Agents; Bacillus subtilis; Benzofurans; Culture Media; Disk Diffusion Antimicrobial Tests; Emericella; Humans; Magnetic Resonance Spectroscopy; Models, Molecular; Molecular Structure; Phthalimides

2016
Practical Synthesis of p- and o-Amino- and Methoxyphenolic Anthraquinones.
    Angewandte Chemie (International ed. in English), 2015, Oct-19, Volume: 54, Issue:43

    Topics: Amination; Amines; Anthraquinones; Benzofurans; Phenols

2015
Talaromycolides A-C, Novel Phenyl-Substituted Phthalides Isolated from the Green Chinese Onion-Derived Fungus Talaromyces pinophilus AF-02.
    Journal of agricultural and food chemistry, 2015, Nov-04, Volume: 63, Issue:43

    Topics: Allium; Anti-Bacterial Agents; Bacteria; Benzofurans; Molecular Structure; Talaromyces

2015
[Establishment and application of HPLC-QAMS for quality evaluation of Chuanxiong Rhizoma].
    Yao xue xue bao = Acta pharmaceutica Sinica, 2015, Volume: 50, Issue:6

    Topics: 4-Butyrolactone; Acetonitriles; Benzofurans; Chromatography, High Pressure Liquid; Coumaric Acids; Drugs, Chinese Herbal; Hydroxybenzoates; Quality Control; Rhizome

2015
Toxicity to Diaphania hyalinata, selectivity to non-target species and phytotoxicity of furanones and phthalide analogues.
    Pest management science, 2016, Volume: 72, Issue:9

    Topics: Animals; Ants; Bees; Benzofurans; Cucumis sativus; Food Chain; Furans; Insecticides; Larva; Moths

2016
Ultra-high performance liquid chromatography with tandem mass spectrometry method for the simultaneous quantitation of five phthalides in rat plasma: Application to a comparative pharmacokinetic study of Huo Luo Xiao Ling Dan and herb-pair extract.
    Journal of separation science, 2016, Volume: 39, Issue:11

    Topics: Administration, Oral; Animals; Arthritis; Benzofurans; Chromatography, High Pressure Liquid; Drugs, Chinese Herbal; Freund's Adjuvant; Male; Medicine, Chinese Traditional; Molecular Structure; Plant Extracts; Rats; Rats, Sprague-Dawley; Tandem Mass Spectrometry

2016
Synthesis of Phthalimide Derivatives as Potential PPAR-γ Ligands.
    Marine drugs, 2016, Jun-08, Volume: 14, Issue:6

    Topics: 3T3-L1 Cells; Adipocytes; Adipogenesis; Animals; Benzofurans; Cell Differentiation; Cell Line, Tumor; Cells, Cultured; Hep G2 Cells; Humans; Ligands; Liver; Mice; Phthalimides; PPAR gamma; Rats

2016
Phthalide Derivatives with Anticoagulation Activities from Angelica sinensis.
    Journal of natural products, 2016, 07-22, Volume: 79, Issue:7

    Topics: Angelica sinensis; Anticoagulants; Benzofurans; Crystallography, X-Ray; Drugs, Chinese Herbal; Fibrinogen; Molecular Structure; Plant Roots; Thrombin

2016
A new phthalide derivative from Peperomia nivalis.
    Natural product research, 2017, Volume: 31, Issue:2

    Topics: Animals; Anti-Bacterial Agents; Antimalarials; Benzofurans; Helicobacter pylori; Magnetic Resonance Spectroscopy; Microbial Sensitivity Tests; Peperomia; Peru; Plasmodium falciparum; Spectrophotometry, Ultraviolet

2017
Palladium-catalyzed carbonylative synthesis of isocoumarins and phthalides by using phenyl formate as a carbon monoxide source.
    Organic & biomolecular chemistry, 2017, Feb-21, Volume: 15, Issue:7

    Topics: Benzofurans; Carbon Monoxide; Catalysis; Formates; Isocoumarins; Molecular Structure; Palladium

2017
Two new phthalide dimers from the rhizomes of Ligusticum chuanxiong.
    Journal of Asian natural products research, 2017, Volume: 19, Issue:7

    Topics: Benzofurans; Circular Dichroism; Drugs, Chinese Herbal; Ligusticum; Molecular Structure; Rhizome; Stereoisomerism

2017
Characterization of the potential new phthalides in Ligusticum chuanxiong Hort. using ultra-performance liquid chromatography coupled with quadrupole time of flight tandem mass spectrometry.
    Journal of separation science, 2017, Volume: 40, Issue:10

    Topics: Benzofurans; Chromatography, Liquid; Drugs, Chinese Herbal; Ligusticum; Tandem Mass Spectrometry

2017
Chemometrics-enhanced one-dimensional/comprehensive two-dimensional gas chromatographic analysis for bioactive terpenoids and phthalides in Chaihu Shugan San essential oils.
    Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2017, May-01, Volume: 1052

    Topics: Benzofurans; Gas Chromatography-Mass Spectrometry; Oils, Volatile; Plant Extracts; Terpenes

2017
Phthalides as promising insecticides against Tuta absoluta (Lepidoptera: Gelechiidae).
    Journal of environmental science and health. Part. B, Pesticides, food contaminants, and agricultural wastes, 2018, Jan-02, Volume: 53, Issue:1

    Topics: Animals; Ants; Bees; Benzofurans; Drug Evaluation, Preclinical; Insecticides; Larva; Lepidoptera

2018
Enantioselective Iridium-Catalyzed Phthalide Formation through Internal Redox Allylation of Phthalaldehydes.
    Angewandte Chemie (International ed. in English), 2018, 01-26, Volume: 57, Issue:5

    Topics: Benzofurans; Catalysis; Esterification; Hydrogenation; Iridium; o-Phthalaldehyde; Oxidation-Reduction; Stereoisomerism

2018
Pharmacokinetics-Based Identification of Potential Therapeutic Phthalides from XueBiJing, a Chinese Herbal Injection Used in Sepsis Management.
    Drug metabolism and disposition: the biological fate of chemicals, 2018, Volume: 46, Issue:6

    Topics: Adolescent; Adult; Angelica sinensis; Animals; Benzofurans; Drugs, Chinese Herbal; Female; Glucuronosyltransferase; Humans; Injections; Male; Rats; Rats, Sprague-Dawley; Sepsis; Young Adult

2018
A strategy to improve the identification reliability of the chemical constituents by high-resolution mass spectrometry-based isomer structure prediction combined with a quantitative structure retention relationship analysis: Phthalide compounds in Chuanxi
    Journal of chromatography. A, 2018, Jun-01, Volume: 1552

    Topics: Benzofurans; Chromatography, High Pressure Liquid; Dimerization; Drugs, Chinese Herbal; Isomerism; Linear Models; Quantitative Structure-Activity Relationship; Reproducibility of Results; Tandem Mass Spectrometry

2018
Isoindolinones, Phthalides, and a Naphthoquinone from the Fruiting Body of Daldinia concentrica.
    Journal of natural products, 2018, 05-25, Volume: 81, Issue:5

    Topics: Ascomycota; Benzofurans; Cell Line; Chromatography, High Pressure Liquid; Human Umbilical Vein Endothelial Cells; Humans; Magnetic Resonance Spectroscopy; Naphthoquinones; Phthalimides

2018
[Identification of chemical constituents in Yangxue Qingnao granule by UPLC-Q-TOF/MS~E].
    Yao xue xue bao = Acta pharmaceutica Sinica, 2016, Volume: 51, Issue:5

    Topics: Alkaloids; Anthraquinones; Benzofurans; Chromatography, High Pressure Liquid; Drugs, Chinese Herbal; Glycosides; Hydroxybenzoates; Monoterpenes; Quality Control; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry

2016
Phthalide dimers from Angelica sinensis and their COX-2 inhibition activity.
    Fitoterapia, 2018, Volume: 129

    Topics: Angelica sinensis; Benzofurans; Crystallography, X-Ray; Cyclooxygenase 2 Inhibitors; Molecular Structure; Plant Roots

2018
Effect of explant type and plant growth regulators on callus induction, growth and secondary metabolites production in Cnidium officinale Makino.
    Molecular biology reports, 2018, Volume: 45, Issue:6

    Topics: Antioxidants; Benzofurans; Cell Culture Techniques; Chromatography, High Pressure Liquid; Cnidium; Flavonoids; Phenols; Plant Growth Regulators; Plant Roots; Plant Shoots

2018
Synthesis of Phthalans Via Copper-Catalyzed Enantioselective Cyclization/Carboetherification of 2-Vinylbenzyl Alcohols.
    Organic letters, 2018, 10-19, Volume: 20, Issue:20

    Topics: Alkenes; Benzofurans; Benzyl Alcohols; Catalysis; Copper; Cyclization; Stereoisomerism; Vinyl Compounds

2018
Toxicity and Sublethal Effects of Phthalides Analogs to Rhyzopertha dominica.
    Chemistry & biodiversity, 2019, Volume: 16, Issue:3

    Topics: Animals; Benzofurans; Coleoptera; Dose-Response Relationship, Drug; Insecticides; Molecular Structure; Structure-Activity Relationship

2019
Characterization of chemical constituents and identification of absorbed components and metabolites in rat plasma of Fu-Ke-Zai-Zao pills by ultra high performance liquid chromatography with quadrupole time-of-flight mass spectrometry.
    Journal of separation science, 2019, Volume: 42, Issue:10

    Topics: Animals; Benzofurans; Chromatography, High Pressure Liquid; Drugs, Chinese Herbal; Female; Flavonoids; Methylation; Monoterpenes; Plasma; Propionates; Quality Control; Rats; Rats, Sprague-Dawley; Saponins; Tandem Mass Spectrometry; Triterpenes

2019
Triangeliphthalides A-D: bioactive phthalide trimers with new skeletons from Angelica sinensis and their production mechanism.
    Chemical communications (Cambridge, England), 2019, May-28, Volume: 55, Issue:44

    Topics: Angelica sinensis; Benzofurans; Biopolymers; Magnetic Resonance Spectroscopy; Models, Molecular; Molecular Structure

2019
Novel phthalide dimers from the aerial parts of Ligusticum sinense Oliv cv. Chaxiong.
    Fitoterapia, 2019, Volume: 137

    Topics: Benzofurans; Cell Line; China; Humans; Ligusticum; Molecular Structure; Phytochemicals; Plant Components, Aerial; Stereoisomerism; X-Ray Diffraction

2019
Light elicited growth, antioxidant enzymes activities and production of medicinal compounds in callus culture of Cnidium officinale Makino.
    Journal of photochemistry and photobiology. B, Biology, 2019, Volume: 196

    Topics: Antioxidants; Ascorbate Peroxidases; Benzofurans; Chromatography, High Pressure Liquid; Cnidium; Flavonoids; Light; Phenols; Plant Cells; Plants, Medicinal; Superoxide Dismutase

2019
New phthalide derivatives from the Biscogniauxia sp. and their activities.
    Fitoterapia, 2019, Volume: 137

    Topics: Anti-Infective Agents; Benzofurans; China; Cholinesterase Inhibitors; Molecular Structure; Xylariales

2019
Phthalides, senkyunolide A and ligustilide, show immunomodulatory effect in improving atherosclerosis, through inhibiting AP-1 and NF-κB expression.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2019, Volume: 117

    Topics: 4-Butyrolactone; Animals; Anti-Inflammatory Agents; Apolipoproteins E; Atherosclerosis; Benzofurans; HEK293 Cells; Humans; Immunologic Factors; Inflammation Mediators; Lipids; Male; Mice, Inbred C57BL; NF-kappa B; Proto-Oncogene Proteins c-akt; Transcription Factor AP-1; Tumor Necrosis Factor Receptor Superfamily, Member 9

2019
[UPLC fingerprint and multi-components content determination of different processed products of Angelica sinensis].
    Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 2019, Volume: 44, Issue:12

    Topics: 4-Butyrolactone; Angelica sinensis; Benzofurans; Chromatography, High Pressure Liquid; Coumaric Acids; Drugs, Chinese Herbal; Hydroxybenzoates; Medicine, Chinese Traditional; Principal Component Analysis

2019
Direct and Metal-Catalyzed Photochemical Dimerization of the Phthalide (
    Organic letters, 2019, 08-16, Volume: 21, Issue:16

    Topics: 4-Butyrolactone; Benzofurans; Catalysis; Crystallography, X-Ray; Cycloaddition Reaction; Dimerization; Metals; Molecular Structure; Photochemistry

2019
Antimicrobial drimane - phthalide derivatives from Hypoxylon fendleri BCC32408.
    Fitoterapia, 2019, Volume: 138

    Topics: Animals; Anti-Infective Agents; Antineoplastic Agents; Bacillus cereus; Benzofurans; Cell Line, Tumor; Chlorocebus aethiops; Humans; Molecular Structure; Plasmodium falciparum; Polycyclic Sesquiterpenes; Sesquiterpenes; Thailand; Vero Cells; Xylariales

2019
Synthesis of phthalide derivatives and evaluation on their antiplatelet aggregation and antioxidant activities.
    Journal of Asian natural products research, 2020, Volume: 22, Issue:12

    Topics: Animals; Antioxidants; Benzofurans; Hydrogen Peroxide; Molecular Structure; Platelet Aggregation Inhibitors; Rats

2020
Synthesis and structural elucidation of a phthalide analog using NMR analysis and DFT calculations.
    Magnetic resonance in chemistry : MRC, 2020, Volume: 58, Issue:6

    Topics: Benzofurans; Carbon Isotopes; Density Functional Theory; Magnetic Resonance Spectroscopy; Protons

2020
Mode of action of 3-butylidene phthalide as a competent natural pesticide.
    Pesticide biochemistry and physiology, 2020, Volume: 164

    Topics: Acetylcholinesterase; Animals; Benzofurans; Cholinesterase Inhibitors; Drosophila melanogaster; Pesticides

2020
Phthalide derivative CD21 ameliorates ischemic brain injury in a mouse model of global cerebral ischemia: involvement of inhibition of NLRP3.
    International immunopharmacology, 2020, Volume: 86

    Topics: Animals; Anti-Inflammatory Agents; Astrocytes; Benzofurans; Body Weight; Brain Injuries; Brain Ischemia; CARD Signaling Adaptor Proteins; Caspase 1; Cathepsins; Cytokines; Disease Models, Animal; HMGB1 Protein; Inflammasomes; Male; Mice, Inbred C57BL; Microglia; Neuroprotective Agents; NF-kappa B p50 Subunit; NLR Family, Pyrin Domain-Containing 3 Protein; Reperfusion Injury; Signal Transduction; Toll-Like Receptor 4

2020
Association of electroanalytical and spectrophotometric methods to evaluate the antioxidant activity of isobenzofuranone in primary cultures of hippocampal neurons.
    Toxicology in vitro : an international journal published in association with BIBRA, 2020, Volume: 68

    Topics: Animals; Antioxidants; Benzofurans; Cell Survival; Cells, Cultured; Female; Hippocampus; Lipid Peroxidation; Male; Mice, Inbred C57BL; Neurons; Reactive Oxygen Species; Spectrophotometry

2020
Novel phthalide derivatives: Synthesis and anti-inflammatory activity in vitro and in vivo.
    European journal of medicinal chemistry, 2020, Nov-15, Volume: 206

    Topics: Animals; Anti-Inflammatory Agents; Benzofurans; Chemistry Techniques, Synthetic; Inhibitory Concentration 50; MAP Kinase Signaling System; Mice; NF-E2-Related Factor 2; NF-kappa B; RAW 264.7 Cells; Reactive Oxygen Species

2020
Dynamic Trapping as a Selective Route to Renewable Phthalide from Biomass-Derived Furfuryl Alcohol.
    Angewandte Chemie (International ed. in English), 2020, 12-21, Volume: 59, Issue:52

    Topics: Benzofurans; Biomass; Cycloaddition Reaction; Furans

2020
Phthalide derivative CD21 alleviates cerebral ischemia-induced neuroinflammation: Involvement of microglial M2 polarization via AMPK activation.
    European journal of pharmacology, 2020, Nov-05, Volume: 886

    Topics: 4-Butyrolactone; AMP-Activated Protein Kinases; Animals; Behavior, Animal; Benzofurans; Brain Ischemia; Cell Line; Cell Polarity; Cytokines; Dose-Response Relationship, Drug; Encephalitis; Enzyme Activation; Infarction, Middle Cerebral Artery; Male; Mice; Mice, Inbred C57BL; Microglia; Neuroprotective Agents; Phenotype; Psychomotor Performance

2020
Lipopeptide Epimers and a Phthalide Glycerol Ether with AChE Inhibitory Activities from the Marine-Derived Fungus
    Marine drugs, 2020, Oct-30, Volume: 18, Issue:11

    Topics: A549 Cells; Acetylcholinesterase; Antineoplastic Agents; Benzofurans; Cholinesterase Inhibitors; Curvularia; Glyceryl Ethers; GPI-Linked Proteins; HeLa Cells; Humans; K562 Cells; Lipopeptides; Molecular Docking Simulation; Molecular Structure; Structure-Activity Relationship

2020
Quality suitability regionalization analysis of Angelica sinensis in Gansu, China.
    PloS one, 2020, Volume: 15, Issue:12

    Topics: 4-Butyrolactone; Angelica sinensis; Benzofurans; China; Chlorogenic Acid; Chromatography, High Pressure Liquid; Coumaric Acids; Plant Extracts

2020
Ophiobolin Sesterterpenoids and Farnesylated Phthalide Derivatives from the Deep Sea Cold-Seep-Derived Fungus
    Journal of natural products, 2020, 12-24, Volume: 83, Issue:12

    Topics: Aspergillus; Benzofurans; Cold Temperature; Oceans and Seas; Prenylation; Sesterterpenes; Spectrum Analysis

2020
New dimeric phthalides from the rhizomes of Ligusticum sinense Oliv.
    Fitoterapia, 2021, Volume: 150

    Topics: Animals; Benzofurans; China; Ligusticum; Mice; Molecular Structure; Nitric Oxide; Phytochemicals; Plants, Medicinal; RAW 264.7 Cells; Rhizome

2021
Novel 3-benzylidene/benzylphthalide Mannich base derivatives as potential multifunctional agents for the treatment of Alzheimer's disease.
    Bioorganic & medicinal chemistry, 2021, 04-01, Volume: 35

    Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Animals; Antioxidants; Benzofurans; Benzylidene Compounds; Blood-Brain Barrier; Butyrylcholinesterase; Cholinesterase Inhibitors; Copper; Dose-Response Relationship, Drug; Electrophorus; Female; Humans; Male; Mannich Bases; Mice; Mice, Inbred Strains; Models, Molecular; Molecular Structure; Neuroprotective Agents; PC12 Cells; Peptide Fragments; Protein Aggregates; Rats; Structure-Activity Relationship

2021
[Pharmacokinetic study on five components in phthalide target areas of Chaxiong and its β-CD inclusion compounds based on UPLC-MS/MS].
    Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 2021, Volume: 46, Issue:4

    Topics: Animals; Benzofurans; Chromatography, High Pressure Liquid; Chromatography, Liquid; Rats; Rats, Sprague-Dawley; Reproducibility of Results; Tandem Mass Spectrometry

2021
Pharmacokinetics of five phthalides in volatile oil of Ligusticum sinense Oliv.cv. Chaxiong, and comparison study on physicochemistry and pharmacokinetics after being formulated into solid dispersion and inclusion compound.
    BMC complementary medicine and therapies, 2021, Apr-22, Volume: 21, Issue:1

    Topics: Administration, Oral; Animals; Benzofurans; Infusions, Intravenous; Ligusticum; Male; Molecular Structure; Phytotherapy; Plant Oils; Rats; Rats, Sprague-Dawley; Rhizome

2021
Identification of novel anti-cancer agents by the synthesis and cellular screening of a noscapine-based library.
    Bioorganic chemistry, 2021, Volume: 115

    Topics: Antineoplastic Agents; Benzofurans; Cell Line, Tumor; Cell Proliferation; Drug Design; Humans; Isoquinolines; Noscapine; Papaver; Protein Binding; Small Molecule Libraries; Tubulin

2021
Facile Synthesis of Alkylidene Phthalides by Rhodium-Catalyzed Domino C-H Acylation/Annulation of Benzamides with Aliphatic Carboxylic Acids.
    Chemistry (Weinheim an der Bergstrasse, Germany), 2021, Nov-11, Volume: 27, Issue:63

    Topics: Acylation; Benzamides; Benzofurans; Carboxylic Acids; Catalysis; Rhodium

2021
Rhytidhylides A and B, Two New Phthalide Derivatives from the Endophytic Fungus
    Molecules (Basel, Switzerland), 2021, Oct-09, Volume: 26, Issue:20

    Topics: Ascomycota; Benzofurans; Cell Line, Tumor; Endophytes; Escherichia coli; Humans; Leptospermum; Molecular Structure

2021
Three New Phthalide Glycosides from the Rhizomes of
    Molecules (Basel, Switzerland), 2021, Nov-21, Volume: 26, Issue:22

    Topics: Animals; Benzofurans; Cnidium; Glycosides; Hair Cells, Auditory; Neomycin; Rhizome; Silicon Dioxide; Zebrafish

2021
Electrochemical Sulfonylation-Induced Lactonization of Alkenes: Synthesis of Sulfonyl Phthalides.
    The Journal of organic chemistry, 2022, 01-21, Volume: 87, Issue:2

    Topics: Alkenes; Benzofurans; Catalysis; Molecular Structure

2022
Phthalide metabolites produced by mangrove endophytic fungus Pestalotiopsis sp. SAS4.
    Magnetic resonance in chemistry : MRC, 2022, Volume: 60, Issue:5

    Topics: Benzofurans; Fungi; Molecular Structure; Pestalotiopsis

2022
Asymmetric Ru/Cinchonine Dual Catalysis for the One-Pot Synthesis of Optically Active Phthalides from Benzoic Acids and Acrylates.
    The Journal of organic chemistry, 2022, 04-01, Volume: 87, Issue:7

    Topics: Acrylates; Benzoates; Benzofurans; Catalysis; Cinchona Alkaloids; Molecular Structure; Stereoisomerism

2022
Isoindolines and phthalides from the rhizomes of Ligusticum chuanxiong and their relaxant effects on the uterine smooth muscle.
    Phytochemistry, 2022, Volume: 198

    Topics: Animals; Benzofurans; Ligusticum; Muscle, Smooth; Oxytocin; Rats; Rhizome

2022
Spiroligustolides A and B: Two pairs of enantiomeric spiro-orthoester-containing phthalide dimers as Ca
    Bioorganic chemistry, 2022, Volume: 123

    Topics: Benzofurans; Calcium Channels; Ligusticum; Molecular Structure; Stereoisomerism

2022
Pd-Catalyzed Tandem [5 + 2] Cycloaddition/Ring Contraction of Phthalide-Derived Alkenes and Vinylethylene Carbonates for the Construction of Benzo-[5,5]-spiroketal Lactones.
    Organic letters, 2022, 05-13, Volume: 24, Issue:18

    Topics: Alkenes; Benzofurans; Carbonates; Catalysis; Cycloaddition Reaction; Furans; Lactones; Palladium; Spiro Compounds

2022
Decarboxylative Allylic Alkylation of Phthalides: Stabilized Benzylic Nucleophiles for sp
    The Journal of organic chemistry, 2022, 06-03, Volume: 87, Issue:11

    Topics: Alkylation; Allyl Compounds; Benzofurans; Catalysis; Molecular Structure; Palladium

2022
Six pairs of enantiomeric phthalide dimers from the rhizomes of Ligusticum chuanxiong and their absolute configurations and anti-inflammatory activities.
    Bioorganic chemistry, 2022, Volume: 127

    Topics: Anti-Inflammatory Agents; Benzofurans; Ligusticum; Molecular Structure; Rhizome

2022
Synthesis and Biological Evaluation of Novel Phthalide Analogs-1,2,4-Oxadiazole Hybrids as Potential Anti-Inflammatory Agents.
    Chemistry & biodiversity, 2022, Volume: 19, Issue:8

    Topics: Animals; Anti-Inflammatory Agents; Benzofurans; Lipopolysaccharides; Mice; NF-kappa B; Nitric Oxide; Nitric Oxide Synthase Type II; Oxadiazoles; RAW 264.7 Cells

2022
Electrochemical C(sp
    Organic letters, 2023, 01-13, Volume: 25, Issue:1

    Topics: Benzofurans; Lactones

2023
Verbalide A~F: new phthalide derivatives from the endophytic fungus Preussia sp. CPCC 400972.
    The Journal of antibiotics, 2023, Volume: 76, Issue:10

    Topics: Ascomycota; Benzofurans; Magnetic Resonance Spectroscopy; Molecular Structure

2023